FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5479, 486 aa 1>>>pF1KB5479 486 - 486 aa - 486 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7449+/-0.000346; mu= 16.4463+/- 0.022 mean_var=88.4509+/-17.493, 0's: 0 Z-trim(117.6): 98 B-trim: 290 in 1/51 Lambda= 0.136371 statistics sampled from 29597 (29710) to 29597 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.703), E-opt: 0.2 (0.348), width: 16 Scan time: 10.480 The best scores are: opt bits E(85289) NP_573419 (OMIM: 602711) amyloid beta A4 precursor ( 486) 3389 676.7 3.9e-194 NP_006042 (OMIM: 602711) amyloid beta A4 precursor ( 493) 3365 672.0 1e-192 NP_573420 (OMIM: 602711) amyloid beta A4 precursor ( 484) 3360 671.0 2e-192 NP_573418 (OMIM: 602711) amyloid beta A4 precursor ( 491) 3360 671.0 2e-192 XP_016863646 (OMIM: 104300,602710) PREDICTED: amyl ( 723) 1112 228.9 3.8e-59 XP_016863645 (OMIM: 104300,602710) PREDICTED: amyl ( 723) 1112 228.9 3.8e-59 XP_016863641 (OMIM: 104300,602710) PREDICTED: amyl ( 739) 1112 228.9 3.8e-59 XP_006714075 (OMIM: 104300,602710) PREDICTED: amyl ( 739) 1112 228.9 3.8e-59 XP_006714074 (OMIM: 104300,602710) PREDICTED: amyl ( 740) 1112 228.9 3.9e-59 XP_016863639 (OMIM: 104300,602710) PREDICTED: amyl ( 740) 1112 228.9 3.9e-59 XP_016863640 (OMIM: 104300,602710) PREDICTED: amyl ( 740) 1112 228.9 3.9e-59 XP_016863638 (OMIM: 104300,602710) PREDICTED: amyl ( 743) 1112 228.9 3.9e-59 XP_016863636 (OMIM: 104300,602710) PREDICTED: amyl ( 744) 1112 228.9 3.9e-59 XP_016863635 (OMIM: 104300,602710) PREDICTED: amyl ( 744) 1112 228.9 3.9e-59 XP_016863637 (OMIM: 104300,602710) PREDICTED: amyl ( 744) 1112 228.9 3.9e-59 XP_006714073 (OMIM: 104300,602710) PREDICTED: amyl ( 760) 1112 228.9 3.9e-59 XP_016863632 (OMIM: 104300,602710) PREDICTED: amyl ( 760) 1112 228.9 3.9e-59 XP_016863633 (OMIM: 104300,602710) PREDICTED: amyl ( 760) 1112 228.9 3.9e-59 XP_006714072 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1112 228.9 3.9e-59 XP_006714070 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1112 228.9 3.9e-59 XP_006714068 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1112 228.9 3.9e-59 XP_011511988 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1112 228.9 3.9e-59 XP_006714071 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1112 228.9 3.9e-59 XP_016863631 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1112 228.9 3.9e-59 XP_016863647 (OMIM: 104300,602710) PREDICTED: amyl ( 721) 1089 224.4 8.7e-58 NP_001317585 (OMIM: 104300,602710) amyloid beta A4 ( 737) 1089 224.4 8.8e-58 NP_001317587 (OMIM: 104300,602710) amyloid beta A4 ( 737) 1089 224.4 8.8e-58 XP_016863642 (OMIM: 104300,602710) PREDICTED: amyl ( 738) 1089 224.4 8.8e-58 XP_011511989 (OMIM: 104300,602710) PREDICTED: amyl ( 738) 1089 224.4 8.8e-58 XP_016863643 (OMIM: 104300,602710) PREDICTED: amyl ( 738) 1089 224.4 8.8e-58 NP_001159522 (OMIM: 104300,602710) amyloid beta A4 ( 758) 1089 224.4 9e-58 NP_004298 (OMIM: 104300,602710) amyloid beta A4 pr ( 759) 1089 224.4 9e-58 XP_016863634 (OMIM: 104300,602710) PREDICTED: amyl ( 759) 1089 224.4 9e-58 NP_775098 (OMIM: 104300,602710) amyloid beta A4 pr ( 736) 1072 221.0 9e-57 NP_001244249 (OMIM: 602709) amyloid beta A4 precur ( 451) 1021 210.8 6.4e-54 NP_001244250 (OMIM: 602709) amyloid beta A4 precur ( 451) 1021 210.8 6.4e-54 XP_011518342 (OMIM: 602709) PREDICTED: amyloid bet ( 451) 1021 210.8 6.4e-54 NP_001244255 (OMIM: 602709) amyloid beta A4 precur ( 451) 1021 210.8 6.4e-54 NP_001244254 (OMIM: 602709) amyloid beta A4 precur ( 475) 1021 210.8 6.7e-54 NP_001244248 (OMIM: 602709) amyloid beta A4 precur ( 490) 1021 210.9 6.8e-54 NP_001155 (OMIM: 602709) amyloid beta A4 precursor ( 710) 1021 211.0 9.1e-54 XP_006718275 (OMIM: 602709) PREDICTED: amyloid bet ( 715) 1021 211.0 9.2e-54 XP_016873128 (OMIM: 602709) PREDICTED: amyloid bet ( 715) 1021 211.0 9.2e-54 XP_006718278 (OMIM: 602709) PREDICTED: amyloid bet ( 802) 1021 211.0 1e-53 XP_016873131 (OMIM: 602709) PREDICTED: amyloid bet ( 449) 998 206.3 1.5e-52 NP_001244252 (OMIM: 602709) amyloid beta A4 precur ( 488) 998 206.3 1.6e-52 NP_663722 (OMIM: 602709) amyloid beta A4 precursor ( 708) 998 206.4 2.1e-52 XP_016873130 (OMIM: 602709) PREDICTED: amyloid bet ( 708) 998 206.4 2.1e-52 XP_006718277 (OMIM: 602709) PREDICTED: amyloid bet ( 713) 998 206.4 2.1e-52 XP_016873129 (OMIM: 602709) PREDICTED: amyloid bet ( 713) 998 206.4 2.1e-52 >>NP_573419 (OMIM: 602711) amyloid beta A4 precursor pro (486 aa) initn: 3389 init1: 3389 opt: 3389 Z-score: 3606.4 bits: 676.7 E(85289): 3.9e-194 Smith-Waterman score: 3389; 100.0% identity (100.0% similar) in 486 aa overlap (1-486:1-486) 10 20 30 40 50 60 pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRDRDFAFVASDKDSCMLKCHVFCCDVPAKAIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRDRDFAFVASDKDSCMLKCHVFCCDVPAKAIA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 SALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALYMGTLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 SALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALYMGTLP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 VTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 VTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCLVASAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 LVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCLVASAA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 RGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 RGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKP 430 440 450 460 470 480 pF1KB5 SLLHMP :::::: NP_573 SLLHMP >>NP_006042 (OMIM: 602711) amyloid beta A4 precursor pro (493 aa) initn: 3375 init1: 1893 opt: 3365 Z-score: 3580.8 bits: 672.0 E(85289): 1e-192 Smith-Waterman score: 3365; 98.6% identity (98.6% similar) in 493 aa overlap (1-486:1-493) 10 20 30 40 50 60 pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRD-------RDFAFVASDKDSCMLKCHVFCCD :::::::::::::::::::::::::::::: ::::::::::::::::::::::: NP_006 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRDSPISAPARDFAFVASDKDSCMLKCHVFCCD 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 VPAKAIASALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VPAKAIASALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 LYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEP 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 LWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQK 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 CLVASAARGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 CLVASAARGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFL 430 440 450 460 470 480 480 pF1KB5 DAFRLKPSLLHMP ::::::::::::: NP_006 DAFRLKPSLLHMP 490 >>NP_573420 (OMIM: 602711) amyloid beta A4 precursor pro (484 aa) initn: 1901 init1: 1901 opt: 3360 Z-score: 3575.6 bits: 671.0 E(85289): 2e-192 Smith-Waterman score: 3360; 99.6% identity (99.6% similar) in 486 aa overlap (1-486:1-484) 10 20 30 40 50 60 pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRDRDFAFVASDKDSCMLKCHVFCCDVPAKAIA :::::::::::::::::::::::::::::: :::::::::::::::::::::::::::: NP_573 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRD--FAFVASDKDSCMLKCHVFCCDVPAKAIA 190 200 210 220 230 250 260 270 280 290 300 pF1KB5 SALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALYMGTLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 SALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALYMGTLP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB5 VTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 VTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVR 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB5 LVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCLVASAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 LVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCLVASAA 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB5 RGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 RGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKP 420 430 440 450 460 470 pF1KB5 SLLHMP :::::: NP_573 SLLHMP 480 >>NP_573418 (OMIM: 602711) amyloid beta A4 precursor pro (491 aa) initn: 3367 init1: 1893 opt: 3360 Z-score: 3575.5 bits: 671.0 E(85289): 2e-192 Smith-Waterman score: 3360; 98.8% identity (98.8% similar) in 491 aa overlap (1-486:1-491) 10 20 30 40 50 60 pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRD-----RDFAFVASDKDSCMLKCHVFCCDVP ::::::::::::::::::::::::::::: ::::::::::::::::::::::::: NP_573 LVNPLDHSLIHCQPLVHIRVWGVGSSKGRPISAPARDFAFVASDKDSCMLKCHVFCCDVP 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 AKAIASALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 AKAIASALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 MGTLPVTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 MGTLPVTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLW 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 QCPVRLVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 QCPVRLVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCL 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 VASAARGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_573 VASAARGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDA 430 440 450 460 470 480 480 pF1KB5 FRLKPSLLHMP ::::::::::: NP_573 FRLKPSLLHMP 490 >>XP_016863646 (OMIM: 104300,602710) PREDICTED: amyloid (723 aa) initn: 1259 init1: 661 opt: 1112 Z-score: 1182.9 bits: 228.9 E(85289): 3.8e-59 Smith-Waterman score: 1323; 43.1% identity (69.1% similar) in 489 aa overlap (18-486:263-723) 10 20 30 40 pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYW :.:.:::.... :::::... : :::::: XP_016 IQNLAPSDEESSWTTLSQDSASPSSPDETADIWSDHSFQTDPDLPPGWKRVSDIAGTYYW 240 250 260 270 280 290 50 60 70 80 90 pF1KB5 HVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRP-PKGR-----------SFSSLESSLD :.:.:.:::.::. .: . :. . : :... :.. .:.. XP_016 HIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPDPSLKEFEGATL 300 310 320 330 340 350 100 110 120 130 140 pF1KB5 RSNSLSWYGG------ESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQ : ::. .. .: . .: :::::::::::::. ::::::::::.::::::.: XP_016 RYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQ 360 370 380 390 400 410 150 160 170 180 190 200 pF1KB5 LAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGR :. .. . : ::::..: .::..: .:::.:.:.:..: ::.: ::::::: ..:: XP_016 LSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDNGR 420 430 440 450 460 470 210 220 230 240 250 260 pF1KB5 DRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPI .::::.:: :::. .:::::: ::.::::::..:: .:..:..:: .... : : : . XP_016 ERDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALA-CSSLQER 480 490 500 510 520 530 270 280 290 300 310 320 pF1KB5 SPE--DLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWV . :.: ::.. .. .::... :.: ::: : .:::.:: :: .: . .... :. XP_016 ANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKEDWL 540 550 560 570 580 590 330 340 350 360 370 380 pF1KB5 PTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQC . ..:.:. .: . .: ..::: : .: ::...:.:::.: :::..: : : : :.: XP_016 SVNMNVADATVT---VISE-KNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFEC 600 610 620 630 640 390 400 410 420 430 440 pF1KB5 AAFWCQPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPGGP .:::.:.::..:::::::::..::::::: : .: : XP_016 HVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQK---------VR------------P 650 660 670 680 450 460 470 480 pF1KB5 LPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKPSLLHMP : : .: .: ::::.:..:... : . .:: XP_016 PPPP--ADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP 690 700 710 720 >>XP_016863645 (OMIM: 104300,602710) PREDICTED: amyloid (723 aa) initn: 1259 init1: 661 opt: 1112 Z-score: 1182.9 bits: 228.9 E(85289): 3.8e-59 Smith-Waterman score: 1323; 43.1% identity (69.1% similar) in 489 aa overlap (18-486:263-723) 10 20 30 40 pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYW :.:.:::.... :::::... : :::::: XP_016 IQNLAPSDEESSWTTLSQDSASPSSPDETADIWSDHSFQTDPDLPPGWKRVSDIAGTYYW 240 250 260 270 280 290 50 60 70 80 90 pF1KB5 HVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRP-PKGR-----------SFSSLESSLD :.:.:.:::.::. .: . :. . : :... :.. .:.. XP_016 HIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPDPSLKEFEGATL 300 310 320 330 340 350 100 110 120 130 140 pF1KB5 RSNSLSWYGG------ESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQ : ::. .. .: . .: :::::::::::::. ::::::::::.::::::.: XP_016 RYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQ 360 370 380 390 400 410 150 160 170 180 190 200 pF1KB5 LAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGR :. .. . : ::::..: .::..: .:::.:.:.:..: ::.: ::::::: ..:: XP_016 LSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDNGR 420 430 440 450 460 470 210 220 230 240 250 260 pF1KB5 DRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPI .::::.:: :::. .:::::: ::.::::::..:: .:..:..:: .... : : : . XP_016 ERDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALA-CSSLQER 480 490 500 510 520 530 270 280 290 300 310 320 pF1KB5 SPE--DLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWV . :.: ::.. .. .::... :.: ::: : .:::.:: :: .: . .... :. XP_016 ANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKEDWL 540 550 560 570 580 590 330 340 350 360 370 380 pF1KB5 PTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQC . ..:.:. .: . .: ..::: : .: ::...:.:::.: :::..: : : : :.: XP_016 SVNMNVADATVT---VISE-KNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFEC 600 610 620 630 640 390 400 410 420 430 440 pF1KB5 AAFWCQPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPGGP .:::.:.::..:::::::::..::::::: : .: : XP_016 HVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQK---------VR------------P 650 660 670 680 450 460 470 480 pF1KB5 LPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKPSLLHMP : : .: .: ::::.:..:... : . .:: XP_016 PPPP--ADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP 690 700 710 720 >>XP_016863641 (OMIM: 104300,602710) PREDICTED: amyloid (739 aa) initn: 1260 init1: 661 opt: 1112 Z-score: 1182.8 bits: 228.9 E(85289): 3.8e-59 Smith-Waterman score: 1324; 43.0% identity (69.0% similar) in 491 aa overlap (16-486:277-739) 10 20 30 40 pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTY . :.:.:::.... :::::... : :::: XP_016 LHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWSDHSFQTDPDLPPGWKRVSDIAGTY 250 260 270 280 290 300 50 60 70 80 90 pF1KB5 YWHVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRP-PKGR-----------SFSSLESS :::.:.:.:::.::. .: . :. . : :... :.. .:.. XP_016 YWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPDPSLKEFEGA 310 320 330 340 350 360 100 110 120 130 140 pF1KB5 LDRSNSLSWYGG------ESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCI : ::. .. .: . .: :::::::::::::. ::::::::::.:::::: XP_016 TLRYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCI 370 380 390 400 410 420 150 160 170 180 190 200 pF1KB5 QQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSK .::. .. . : ::::..: .::..: .:::.:.:.:..: ::.: ::::::: .. XP_016 RQLSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDN 430 440 450 460 470 480 210 220 230 240 250 260 pF1KB5 GRDRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPD ::.::::.:: :::. .:::::: ::.::::::..:: .:..:..:: .... : : : . XP_016 GRERDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALA-CSSLQ 490 500 510 520 530 540 270 280 290 300 310 320 pF1KB5 PISPE--DLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNA . :.: ::.. .. .::... :.: ::: : .:::.:: :: .: . .... XP_016 ERANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKED 550 560 570 580 590 600 330 340 350 360 370 380 pF1KB5 WVPTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSF :. . ..:.:. .: . .: ..::: : .: ::...:.:::.: :::..: : : : : XP_016 WLSVNMNVADATVT---VISE-KNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRF 610 620 630 640 650 660 390 400 410 420 430 440 pF1KB5 QCAAFWCQPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPG .: .:::.:.::..:::::::::..::::::: : .: XP_016 ECHVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQK---------VR----------- 670 680 690 700 450 460 470 480 pF1KB5 GPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKPSLLHMP : : : .: .: ::::.:..:... : . .:: XP_016 -PPPPP--ADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP 710 720 730 >>XP_006714075 (OMIM: 104300,602710) PREDICTED: amyloid (739 aa) initn: 1260 init1: 661 opt: 1112 Z-score: 1182.8 bits: 228.9 E(85289): 3.8e-59 Smith-Waterman score: 1324; 43.0% identity (69.0% similar) in 491 aa overlap (16-486:277-739) 10 20 30 40 pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTY . :.:.:::.... :::::... : :::: XP_006 LHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWSDHSFQTDPDLPPGWKRVSDIAGTY 250 260 270 280 290 300 50 60 70 80 90 pF1KB5 YWHVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRP-PKGR-----------SFSSLESS :::.:.:.:::.::. .: . :. . : :... :.. .:.. XP_006 YWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPDPSLKEFEGA 310 320 330 340 350 360 100 110 120 130 140 pF1KB5 LDRSNSLSWYGG------ESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCI : ::. .. .: . .: :::::::::::::. ::::::::::.:::::: XP_006 TLRYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCI 370 380 390 400 410 420 150 160 170 180 190 200 pF1KB5 QQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSK .::. .. . : ::::..: .::..: .:::.:.:.:..: ::.: ::::::: .. XP_006 RQLSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDN 430 440 450 460 470 480 210 220 230 240 250 260 pF1KB5 GRDRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPD ::.::::.:: :::. .:::::: ::.::::::..:: .:..:..:: .... : : : . XP_006 GRERDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALA-CSSLQ 490 500 510 520 530 540 270 280 290 300 310 320 pF1KB5 PISPE--DLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNA . :.: ::.. .. .::... :.: ::: : .:::.:: :: .: . .... XP_006 ERANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKED 550 560 570 580 590 600 330 340 350 360 370 380 pF1KB5 WVPTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSF :. . ..:.:. .: . .: ..::: : .: ::...:.:::.: :::..: : : : : XP_006 WLSVNMNVADATVT---VISE-KNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRF 610 620 630 640 650 660 390 400 410 420 430 440 pF1KB5 QCAAFWCQPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPG .: .:::.:.::..:::::::::..::::::: : .: XP_006 ECHVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQK---------VR----------- 670 680 690 700 450 460 470 480 pF1KB5 GPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKPSLLHMP : : : .: .: ::::.:..:... : . .:: XP_006 -PPPPP--ADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP 710 720 730 >>XP_006714074 (OMIM: 104300,602710) PREDICTED: amyloid (740 aa) initn: 1259 init1: 661 opt: 1112 Z-score: 1182.7 bits: 228.9 E(85289): 3.9e-59 Smith-Waterman score: 1323; 43.1% identity (69.1% similar) in 489 aa overlap (18-486:280-740) 10 20 30 40 pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYW :.:.:::.... :::::... : :::::: XP_006 IQNLAPSDEESSWTTLSQDSASPSSPDETADIWSDHSFQTDPDLPPGWKRVSDIAGTYYW 250 260 270 280 290 300 50 60 70 80 90 pF1KB5 HVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRP-PKGR-----------SFSSLESSLD :.:.:.:::.::. .: . :. . : :... :.. .:.. XP_006 HIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPDPSLKEFEGATL 310 320 330 340 350 360 100 110 120 130 140 pF1KB5 RSNSLSWYGG------ESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQ : ::. .. .: . .: :::::::::::::. ::::::::::.::::::.: XP_006 RYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQ 370 380 390 400 410 420 150 160 170 180 190 200 pF1KB5 LAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGR :. .. . : ::::..: .::..: .:::.:.:.:..: ::.: ::::::: ..:: XP_006 LSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDNGR 430 440 450 460 470 480 210 220 230 240 250 260 pF1KB5 DRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPI .::::.:: :::. .:::::: ::.::::::..:: .:..:..:: .... : : : . XP_006 ERDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALA-CSSLQER 490 500 510 520 530 540 270 280 290 300 310 320 pF1KB5 SPE--DLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWV . :.: ::.. .. .::... :.: ::: : .:::.:: :: .: . .... :. XP_006 ANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKEDWL 550 560 570 580 590 600 330 340 350 360 370 380 pF1KB5 PTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQC . ..:.:. .: . .: ..::: : .: ::...:.:::.: :::..: : : : :.: XP_006 SVNMNVADATVT---VISE-KNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFEC 610 620 630 640 650 660 390 400 410 420 430 440 pF1KB5 AAFWCQPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPGGP .:::.:.::..:::::::::..::::::: : .: : XP_006 HVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQK---------VR------------P 670 680 690 700 450 460 470 480 pF1KB5 LPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKPSLLHMP : : .: .: ::::.:..:... : . .:: XP_006 PPPP--ADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP 710 720 730 740 >>XP_016863639 (OMIM: 104300,602710) PREDICTED: amyloid (740 aa) initn: 1259 init1: 661 opt: 1112 Z-score: 1182.7 bits: 228.9 E(85289): 3.9e-59 Smith-Waterman score: 1323; 43.1% identity (69.1% similar) in 489 aa overlap (18-486:280-740) 10 20 30 40 pF1KB5 MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYW :.:.:::.... :::::... : :::::: XP_016 IQNLAPSDEESSWTTLSQDSASPSSPDETADIWSDHSFQTDPDLPPGWKRVSDIAGTYYW 250 260 270 280 290 300 50 60 70 80 90 pF1KB5 HVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRP-PKGR-----------SFSSLESSLD :.:.:.:::.::. .: . :. . : :... :.. .:.. XP_016 HIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPDPSLKEFEGATL 310 320 330 340 350 360 100 110 120 130 140 pF1KB5 RSNSLSWYGG------ESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQ : ::. .. .: . .: :::::::::::::. ::::::::::.::::::.: XP_016 RYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQ 370 380 390 400 410 420 150 160 170 180 190 200 pF1KB5 LAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGR :. .. . : ::::..: .::..: .:::.:.:.:..: ::.: ::::::: ..:: XP_016 LSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDNGR 430 440 450 460 470 480 210 220 230 240 250 260 pF1KB5 DRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPI .::::.:: :::. .:::::: ::.::::::..:: .:..:..:: .... : : : . XP_016 ERDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALA-CSSLQER 490 500 510 520 530 540 270 280 290 300 310 320 pF1KB5 SPE--DLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWV . :.: ::.. .. .::... :.: ::: : .:::.:: :: .: . .... :. XP_016 ANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKEDWL 550 560 570 580 590 600 330 340 350 360 370 380 pF1KB5 PTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQC . ..:.:. .: . .: ..::: : .: ::...:.:::.: :::..: : : : :.: XP_016 SVNMNVADATVT---VISE-KNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFEC 610 620 630 640 650 660 390 400 410 420 430 440 pF1KB5 AAFWCQPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPGGP .:::.:.::..:::::::::..::::::: : .: : XP_016 HVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQK---------VR------------P 670 680 690 700 450 460 470 480 pF1KB5 LPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKPSLLHMP : : .: .: ::::.:..:... : . .:: XP_016 PPPP--ADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP 710 720 730 740 486 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 08:45:07 2016 done: Thu Nov 3 08:45:09 2016 Total Scan time: 10.480 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]