Result of FASTA (omim) for pF1KSDB0046
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDB0046, 1975 aa
  1>>>pF1KSDB0046 1975 - 1975 aa - 1975 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 10.6917+/-0.000455; mu= -0.3111+/- 0.028
 mean_var=266.3591+/-54.162, 0's: 0 Z-trim(118.2): 7  B-trim: 512 in 1/55
 Lambda= 0.078585
 statistics sampled from 30905 (30912) to 30905 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.687), E-opt: 0.2 (0.362), width:  16
 Scan time: 19.700

The best scores are:                                      opt bits E(85289)
NP_001135451 (OMIM: 605230) tumor suppressor p53-b (1975) 13040 1493.4       0
NP_001135452 (OMIM: 605230) tumor suppressor p53-b (1977) 13026 1491.8       0
NP_005648 (OMIM: 605230) tumor suppressor p53-bind (1972) 12988 1487.5       0
XP_011520288 (OMIM: 605230) PREDICTED: tumor suppr (1700) 11127 1276.5       0
XP_011520287 (OMIM: 605230) PREDICTED: tumor suppr (1927) 8964 1031.3       0
XP_016878022 (OMIM: 605230) PREDICTED: tumor suppr (1017) 6742 779.2       0


>>NP_001135451 (OMIM: 605230) tumor suppressor p53-bindi  (1975 aa)
 initn: 13040 init1: 13040 opt: 13040  Z-score: 7998.3  bits: 1493.4 E(85289):    0
Smith-Waterman score: 13040; 100.0% identity (100.0% similar) in 1975 aa overlap (1-1975:1-1975)

               10        20        30        40        50        60
pF1KSD MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD NPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVADPVDSSNLDTCGSISQVIEQLPQPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVADPVDSSNLDTCGSISQVIEQLPQPN
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD RTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKD
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD IPVTAQPSKDVHVVKEQNPPPARSEDMPFSPKASVAAMEAKEQLSAQELMESGLQIQKSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPVTAQPSKDVHVVKEQNPPPARSEDMPFSPKASVAAMEAKEQLSAQELMESGLQIQKSP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD EPEVLSTQEDLFDQSNKTVSSDGCSTPSREEGGCSLASTPATTLHLLQLSGQRSLVQDSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPEVLSTQEDLFDQSNKTVSSDGCSTPSREEGGCSLASTPATTLHLLQLSGQRSLVQDSL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD STNSSDLVAPSPDAFRSTPFIVPSSPTEQEGRQDKPMDTSVLSEEGGEPFQKKLQSGEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STNSSDLVAPSPDAFRSTPFIVPSSPTEQEGRQDKPMDTSVLSEEGGEPFQKKLQSGEPV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD ELENPPLLPESTVSPQASTPISQSTPVFPPGSLPIPSQPQFSHDIFIPSPSLEEQSNDGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELENPPLLPESTVSPQASTPISQSTPVFPPGSLPIPSQPQFSHDIFIPSPSLEEQSNDGK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD KDGDMHSSSLTVECSKTSEIEPKNSPEDLGLSLTGDSCKLMLSTSEYSQSPKMESLSSHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDGDMHSSSLTVECSKTSEIEPKNSPEDLGLSLTGDSCKLMLSTSEYSQSPKMESLSSHR
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD IDEDGENTQIEDTEPMSPVLNSKFVPAENDSILMNPAQDGEVQLSQNDDKTKGDDTDTRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDEDGENTQIEDTEPMSPVLNSKFVPAENDSILMNPAQDGEVQLSQNDDKTKGDDTDTRD
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD DISILATGCKGREETVAEDVCIDLTCDSGSQAVPSPATRSEALSSVLDQEEAMEIKEHHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DISILATGCKGREETVAEDVCIDLTCDSGSQAVPSPATRSEALSSVLDQEEAMEIKEHHP
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD EEGSSGSEVEEIPETPCESQGEELKEENMESVPLHLSLTETQSQGLCLQKEMPKKECSEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEGSSGSEVEEIPETPCESQGEELKEENMESVPLHLSLTETQSQGLCLQKEMPKKECSEA
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD MEVETSVISIDSPQKLAILDQELEHKEQEAWEEATSEDSSVVIVDVKEPSPRVDVSCEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEVETSVISIDSPQKLAILDQELEHKEQEAWEEATSEDSSVVIVDVKEPSPRVDVSCEPL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD EGVEKCSDSQSWEDIAPEIEPCAENRLDTKEEKSVEYEGDLKSGTAETEPVEQDSSQPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGVEKCSDSQSWEDIAPEIEPCAENRLDTKEEKSVEYEGDLKSGTAETEPVEQDSSQPSL
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD PLVRADDPLRLDQELQQPQTQEKTSNSLTEDSKMANAKQLSSDAEAQKLGKPSAHASQSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLVRADDPLRLDQELQQPQTQEKTSNSLTEDSKMANAKQLSSDAEAQKLGKPSAHASQSF
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD CESSSETPFHFTLPKEGDIIPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CESSSETPFHFTLPKEGDIIPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDV
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD MSESMVETHDPILGSGKGDSGAAPDVDDKLCLRMKLVSPETEASEESLQFNLEKPATGER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSESMVETHDPILGSGKGDSGAAPDVDDKLCLRMKLVSPETEASEESLQFNLEKPATGER
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD KNGSTAVAESVASPQKTMSVLSCICEARQENEARSEDPPTTPIRGNLLHFPSSQGEEEKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNGSTAVAESVASPQKTMSVLSCICEARQENEARSEDPPTTPIRGNLLHFPSSQGEEEKE
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD KLEGDHTIRQSQQPMKPISPVKDPVSPASQKMVIQGPSSPQGEAMVTDVLEDQKEGRSTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLEGDHTIRQSQQPMKPISPVKDPVSPASQKMVIQGPSSPQGEAMVTDVLEDQKEGRSTN
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD KENPSKALIERPSQNNIGIQTMECSLRVPETVSAATQTIKNVCEQGTSTVDQNFGKQDAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KENPSKALIERPSQNNIGIQTMECSLRVPETVSAATQTIKNVCEQGTSTVDQNFGKQDAT
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KSD VQTERGSGEKPVSAPGDDTESLHSQGEEEFDMPQPPHGHVLHRHMRTIREVRTLVTRVIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQTERGSGEKPVSAPGDDTESLHSQGEEEFDMPQPPHGHVLHRHMRTIREVRTLVTRVIT
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KSD DVYYVDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSLHRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVYYVDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSLHRT
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KSD SSGTSLSAMHSSGSSGKGAGPLRGKTSGTEPADFALPSSRGGPGKLSPRKGVSQTGTPVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSGTSLSAMHSSGSSGKGAGPLRGKTSGTEPADFALPSSRGGPGKLSPRKGVSQTGTPVC
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KSD EEDGDAGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETAVPGPLGIEDISPNLSPDDKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEDGDAGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETAVPGPLGIEDISPNLSPDDKS
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KSD FSRVVPRVPDSTRRTDVGAGALRRSDSPEIPFQAAAGPSDGLDASSPGNSFVGLRVVAKW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSRVVPRVPDSTRRTDVGAGALRRSDSPEIPFQAAAGPSDGLDASSPGNSFVGLRVVAKW
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KSD SSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSA
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KSD GVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTKAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTKAA
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KSD DISLDNLVEGKRKRRSNVSSPATPTASSSSSTTPTRKITESPRASMGVLSGKRKLITSEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DISLDNLVEGKRKRRSNVSSPATPTASSSSSTTPTRKITESPRASMGVLSGKRKLITSEE
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KSD ERSPAKRGRKSATVKPVGAGEFVSPCESGDNTGEPSALEEQRGPLPLNKTLFLGYAFLLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERSPAKRGRKSATVKPVGAGEFVSPCESGDNTGEPSALEEQRGPLPLNKTLFLGYAFLLT
             1690      1700      1710      1720      1730      1740

             1750      1760      1770      1780      1790      1800
pF1KSD MATTSDKLASRSKLPDGPTGSSEEEEEFLEIPPFNKQYTESQLRAGAGYILEDFNEAQCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MATTSDKLASRSKLPDGPTGSSEEEEEFLEIPPFNKQYTESQLRAGAGYILEDFNEAQCN
             1750      1760      1770      1780      1790      1800

             1810      1820      1830      1840      1850      1860
pF1KSD TAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLEEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLEEQ
             1810      1820      1830      1840      1850      1860

             1870      1880      1890      1900      1910      1920
pF1KSD RILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALGVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALGVF
             1870      1880      1890      1900      1910      1920

             1930      1940      1950      1960      1970     
pF1KSD DVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYKHDYVSH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYKHDYVSH
             1930      1940      1950      1960      1970     

>>NP_001135452 (OMIM: 605230) tumor suppressor p53-bindi  (1977 aa)
 initn: 11131 init1: 11131 opt: 13026  Z-score: 7989.8  bits: 1491.8 E(85289):    0
Smith-Waterman score: 13026; 99.9% identity (99.9% similar) in 1977 aa overlap (1-1975:1-1977)

               10        20        30        40        50        60
pF1KSD MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD NPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVADPVDSSNLDTCGSISQVIEQLPQPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVADPVDSSNLDTCGSISQVIEQLPQPN
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD RTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKD
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD IPVTAQPSKDVHVVKEQNPPPARSEDMPFSPKASVAAMEAKEQLSAQELMESGLQIQKSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPVTAQPSKDVHVVKEQNPPPARSEDMPFSPKASVAAMEAKEQLSAQELMESGLQIQKSP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD EPEVLSTQEDLFDQSNKTVSSDGCSTPSREEGGCSLASTPATTLHLLQLSGQRSLVQDSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPEVLSTQEDLFDQSNKTVSSDGCSTPSREEGGCSLASTPATTLHLLQLSGQRSLVQDSL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD STNSSDLVAPSPDAFRSTPFIVPSSPTEQEGRQDKPMDTSVLSEEGGEPFQKKLQSGEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STNSSDLVAPSPDAFRSTPFIVPSSPTEQEGRQDKPMDTSVLSEEGGEPFQKKLQSGEPV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD ELENPPLLPESTVSPQASTPISQSTPVFPPGSLPIPSQPQFSHDIFIPSPSLEEQSNDGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELENPPLLPESTVSPQASTPISQSTPVFPPGSLPIPSQPQFSHDIFIPSPSLEEQSNDGK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD KDGDMHSSSLTVECSKTSEIEPKNSPEDLGLSLTGDSCKLMLSTSEYSQSPKMESLSSHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDGDMHSSSLTVECSKTSEIEPKNSPEDLGLSLTGDSCKLMLSTSEYSQSPKMESLSSHR
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD IDEDGENTQIEDTEPMSPVLNSKFVPAENDSILMNPAQDGEVQLSQNDDKTKGDDTDTRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDEDGENTQIEDTEPMSPVLNSKFVPAENDSILMNPAQDGEVQLSQNDDKTKGDDTDTRD
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD DISILATGCKGREETVAEDVCIDLTCDSGSQAVPSPATRSEALSSVLDQEEAMEIKEHHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DISILATGCKGREETVAEDVCIDLTCDSGSQAVPSPATRSEALSSVLDQEEAMEIKEHHP
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD EEGSSGSEVEEIPETPCESQGEELKEENMESVPLHLSLTETQSQGLCLQKEMPKKECSEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEGSSGSEVEEIPETPCESQGEELKEENMESVPLHLSLTETQSQGLCLQKEMPKKECSEA
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD MEVETSVISIDSPQKLAILDQELEHKEQEAWEEATSEDSSVVIVDVKEPSPRVDVSCEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEVETSVISIDSPQKLAILDQELEHKEQEAWEEATSEDSSVVIVDVKEPSPRVDVSCEPL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD EGVEKCSDSQSWEDIAPEIEPCAENRLDTKEEKSVEYEGDLKSGTAETEPVEQDSSQPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGVEKCSDSQSWEDIAPEIEPCAENRLDTKEEKSVEYEGDLKSGTAETEPVEQDSSQPSL
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD PLVRADDPLRLDQELQQPQTQEKTSNSLTEDSKMANAKQLSSDAEAQKLGKPSAHASQSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLVRADDPLRLDQELQQPQTQEKTSNSLTEDSKMANAKQLSSDAEAQKLGKPSAHASQSF
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD CESSSETPFHFTLPKEGDIIPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CESSSETPFHFTLPKEGDIIPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDV
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD MSESMVETHDPILGSGKGDSGAAPDVDDKLCLRMKLVSPETEASEESLQFNLEKPATGER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSESMVETHDPILGSGKGDSGAAPDVDDKLCLRMKLVSPETEASEESLQFNLEKPATGER
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD KNGSTAVAESVASPQKTMSVLSCICEARQENEARSEDPPTTPIRGNLLHFPSSQGEEEKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNGSTAVAESVASPQKTMSVLSCICEARQENEARSEDPPTTPIRGNLLHFPSSQGEEEKE
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD KLEGDHTIRQSQQPMKPISPVKDPVSPASQKMVIQGPSSPQGEAMVTDVLEDQKEGRSTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLEGDHTIRQSQQPMKPISPVKDPVSPASQKMVIQGPSSPQGEAMVTDVLEDQKEGRSTN
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD KENPSKALIERPSQNNIGIQTMECSLRVPETVSAATQTIKNVCEQGTSTVDQNFGKQDAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KENPSKALIERPSQNNIGIQTMECSLRVPETVSAATQTIKNVCEQGTSTVDQNFGKQDAT
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KSD VQTERGSGEKPVSAPGDDTESLHSQGEEEFDMPQPPHGHVLHRHMRTIREVRTLVTRVIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQTERGSGEKPVSAPGDDTESLHSQGEEEFDMPQPPHGHVLHRHMRTIREVRTLVTRVIT
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KSD DVYYVDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSLHRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVYYVDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSLHRT
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KSD SSGTSLSAMHSSGSSGKGAGPLRGKTSGTEPADFALPSSRGGPGKLSPRKGVSQTGTPVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSGTSLSAMHSSGSSGKGAGPLRGKTSGTEPADFALPSSRGGPGKLSPRKGVSQTGTPVC
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KSD EEDGDAGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETAVPGPLGIEDISPNLSPDDKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEDGDAGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETAVPGPLGIEDISPNLSPDDKS
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KSD FSRVVPRVPDSTRRTDVGAGALRRSDSPEIPFQAAAGPSDGLDASSPGNSFVGLRVVAKW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSRVVPRVPDSTRRTDVGAGALRRSDSPEIPFQAAAGPSDGLDASSPGNSFVGLRVVAKW
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KSD SSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSA
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KSD GVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTKAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTKAA
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KSD DISLDNLVEGKRKRRSNVSSPATPTASSSSSTTPTRKITESPRASMGVLSGKRKLITSEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DISLDNLVEGKRKRRSNVSSPATPTASSSSSTTPTRKITESPRASMGVLSGKRKLITSEE
             1630      1640      1650      1660      1670      1680

             1690        1700      1710      1720      1730        
pF1KSD ERSPAKRGRKSATVKP--VGAGEFVSPCESGDNTGEPSALEEQRGPLPLNKTLFLGYAFL
       ::::::::::::::::  ::::::::::::::::::::::::::::::::::::::::::
NP_001 ERSPAKRGRKSATVKPGAVGAGEFVSPCESGDNTGEPSALEEQRGPLPLNKTLFLGYAFL
             1690      1700      1710      1720      1730      1740

     1740      1750      1760      1770      1780      1790        
pF1KSD LTMATTSDKLASRSKLPDGPTGSSEEEEEFLEIPPFNKQYTESQLRAGAGYILEDFNEAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTMATTSDKLASRSKLPDGPTGSSEEEEEFLEIPPFNKQYTESQLRAGAGYILEDFNEAQ
             1750      1760      1770      1780      1790      1800

     1800      1810      1820      1830      1840      1850        
pF1KSD CNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLE
             1810      1820      1830      1840      1850      1860

     1860      1870      1880      1890      1900      1910        
pF1KSD EQRILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQRILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALG
             1870      1880      1890      1900      1910      1920

     1920      1930      1940      1950      1960      1970     
pF1KSD VFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYKHDYVSH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYKHDYVSH
             1930      1940      1950      1960      1970       

>>NP_005648 (OMIM: 605230) tumor suppressor p53-binding   (1972 aa)
 initn: 11093 init1: 11093 opt: 12988  Z-score: 7966.5  bits: 1487.5 E(85289):    0
Smith-Waterman score: 12988; 99.9% identity (99.9% similar) in 1972 aa overlap (6-1975:1-1972)

               10        20        30        40        50        60
pF1KSD MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKE
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005      MDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKE
                    10        20        30        40        50     

               70        80        90       100       110       120
pF1KSD NPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVADPVDSSNLDTCGSISQVIEQLPQPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVADPVDSSNLDTCGSISQVIEQLPQPN
          60        70        80        90       100       110     

              130       140       150       160       170       180
pF1KSD RTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
         120       130       140       150       160       170     

              190       200       210       220       230       240
pF1KSD SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKD
         180       190       200       210       220       230     

              250       260       270       280       290       300
pF1KSD IPVTAQPSKDVHVVKEQNPPPARSEDMPFSPKASVAAMEAKEQLSAQELMESGLQIQKSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 IPVTAQPSKDVHVVKEQNPPPARSEDMPFSPKASVAAMEAKEQLSAQELMESGLQIQKSP
         240       250       260       270       280       290     

              310       320       330       340       350       360
pF1KSD EPEVLSTQEDLFDQSNKTVSSDGCSTPSREEGGCSLASTPATTLHLLQLSGQRSLVQDSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EPEVLSTQEDLFDQSNKTVSSDGCSTPSREEGGCSLASTPATTLHLLQLSGQRSLVQDSL
         300       310       320       330       340       350     

              370       380       390       400       410       420
pF1KSD STNSSDLVAPSPDAFRSTPFIVPSSPTEQEGRQDKPMDTSVLSEEGGEPFQKKLQSGEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 STNSSDLVAPSPDAFRSTPFIVPSSPTEQEGRQDKPMDTSVLSEEGGEPFQKKLQSGEPV
         360       370       380       390       400       410     

              430       440       450       460       470       480
pF1KSD ELENPPLLPESTVSPQASTPISQSTPVFPPGSLPIPSQPQFSHDIFIPSPSLEEQSNDGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ELENPPLLPESTVSPQASTPISQSTPVFPPGSLPIPSQPQFSHDIFIPSPSLEEQSNDGK
         420       430       440       450       460       470     

              490       500       510       520       530       540
pF1KSD KDGDMHSSSLTVECSKTSEIEPKNSPEDLGLSLTGDSCKLMLSTSEYSQSPKMESLSSHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KDGDMHSSSLTVECSKTSEIEPKNSPEDLGLSLTGDSCKLMLSTSEYSQSPKMESLSSHR
         480       490       500       510       520       530     

              550       560       570       580       590       600
pF1KSD IDEDGENTQIEDTEPMSPVLNSKFVPAENDSILMNPAQDGEVQLSQNDDKTKGDDTDTRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 IDEDGENTQIEDTEPMSPVLNSKFVPAENDSILMNPAQDGEVQLSQNDDKTKGDDTDTRD
         540       550       560       570       580       590     

              610       620       630       640       650       660
pF1KSD DISILATGCKGREETVAEDVCIDLTCDSGSQAVPSPATRSEALSSVLDQEEAMEIKEHHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DISILATGCKGREETVAEDVCIDLTCDSGSQAVPSPATRSEALSSVLDQEEAMEIKEHHP
         600       610       620       630       640       650     

              670       680       690       700       710       720
pF1KSD EEGSSGSEVEEIPETPCESQGEELKEENMESVPLHLSLTETQSQGLCLQKEMPKKECSEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EEGSSGSEVEEIPETPCESQGEELKEENMESVPLHLSLTETQSQGLCLQKEMPKKECSEA
         660       670       680       690       700       710     

              730       740       750       760       770       780
pF1KSD MEVETSVISIDSPQKLAILDQELEHKEQEAWEEATSEDSSVVIVDVKEPSPRVDVSCEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MEVETSVISIDSPQKLAILDQELEHKEQEAWEEATSEDSSVVIVDVKEPSPRVDVSCEPL
         720       730       740       750       760       770     

              790       800       810       820       830       840
pF1KSD EGVEKCSDSQSWEDIAPEIEPCAENRLDTKEEKSVEYEGDLKSGTAETEPVEQDSSQPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EGVEKCSDSQSWEDIAPEIEPCAENRLDTKEEKSVEYEGDLKSGTAETEPVEQDSSQPSL
         780       790       800       810       820       830     

              850       860       870       880       890       900
pF1KSD PLVRADDPLRLDQELQQPQTQEKTSNSLTEDSKMANAKQLSSDAEAQKLGKPSAHASQSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PLVRADDPLRLDQELQQPQTQEKTSNSLTEDSKMANAKQLSSDAEAQKLGKPSAHASQSF
         840       850       860       870       880       890     

              910       920       930       940       950       960
pF1KSD CESSSETPFHFTLPKEGDIIPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CESSSETPFHFTLPKEGDIIPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDV
         900       910       920       930       940       950     

              970       980       990      1000      1010      1020
pF1KSD MSESMVETHDPILGSGKGDSGAAPDVDDKLCLRMKLVSPETEASEESLQFNLEKPATGER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MSESMVETHDPILGSGKGDSGAAPDVDDKLCLRMKLVSPETEASEESLQFNLEKPATGER
         960       970       980       990      1000      1010     

             1030      1040      1050      1060      1070      1080
pF1KSD KNGSTAVAESVASPQKTMSVLSCICEARQENEARSEDPPTTPIRGNLLHFPSSQGEEEKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KNGSTAVAESVASPQKTMSVLSCICEARQENEARSEDPPTTPIRGNLLHFPSSQGEEEKE
        1020      1030      1040      1050      1060      1070     

             1090      1100      1110      1120      1130      1140
pF1KSD KLEGDHTIRQSQQPMKPISPVKDPVSPASQKMVIQGPSSPQGEAMVTDVLEDQKEGRSTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KLEGDHTIRQSQQPMKPISPVKDPVSPASQKMVIQGPSSPQGEAMVTDVLEDQKEGRSTN
        1080      1090      1100      1110      1120      1130     

             1150      1160      1170      1180      1190      1200
pF1KSD KENPSKALIERPSQNNIGIQTMECSLRVPETVSAATQTIKNVCEQGTSTVDQNFGKQDAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KENPSKALIERPSQNNIGIQTMECSLRVPETVSAATQTIKNVCEQGTSTVDQNFGKQDAT
        1140      1150      1160      1170      1180      1190     

             1210      1220      1230      1240      1250      1260
pF1KSD VQTERGSGEKPVSAPGDDTESLHSQGEEEFDMPQPPHGHVLHRHMRTIREVRTLVTRVIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VQTERGSGEKPVSAPGDDTESLHSQGEEEFDMPQPPHGHVLHRHMRTIREVRTLVTRVIT
        1200      1210      1220      1230      1240      1250     

             1270      1280      1290      1300      1310      1320
pF1KSD DVYYVDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSLHRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DVYYVDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSLHRT
        1260      1270      1280      1290      1300      1310     

             1330      1340      1350      1360      1370      1380
pF1KSD SSGTSLSAMHSSGSSGKGAGPLRGKTSGTEPADFALPSSRGGPGKLSPRKGVSQTGTPVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SSGTSLSAMHSSGSSGKGAGPLRGKTSGTEPADFALPSSRGGPGKLSPRKGVSQTGTPVC
        1320      1330      1340      1350      1360      1370     

             1390      1400      1410      1420      1430      1440
pF1KSD EEDGDAGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETAVPGPLGIEDISPNLSPDDKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EEDGDAGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETAVPGPLGIEDISPNLSPDDKS
        1380      1390      1400      1410      1420      1430     

             1450      1460      1470      1480      1490      1500
pF1KSD FSRVVPRVPDSTRRTDVGAGALRRSDSPEIPFQAAAGPSDGLDASSPGNSFVGLRVVAKW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FSRVVPRVPDSTRRTDVGAGALRRSDSPEIPFQAAAGPSDGLDASSPGNSFVGLRVVAKW
        1440      1450      1460      1470      1480      1490     

             1510      1520      1530      1540      1550      1560
pF1KSD SSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSA
        1500      1510      1520      1530      1540      1550     

             1570      1580      1590      1600      1610      1620
pF1KSD GVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTKAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTKAA
        1560      1570      1580      1590      1600      1610     

             1630      1640      1650      1660      1670      1680
pF1KSD DISLDNLVEGKRKRRSNVSSPATPTASSSSSTTPTRKITESPRASMGVLSGKRKLITSEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DISLDNLVEGKRKRRSNVSSPATPTASSSSSTTPTRKITESPRASMGVLSGKRKLITSEE
        1620      1630      1640      1650      1660      1670     

             1690        1700      1710      1720      1730        
pF1KSD ERSPAKRGRKSATVKP--VGAGEFVSPCESGDNTGEPSALEEQRGPLPLNKTLFLGYAFL
       ::::::::::::::::  ::::::::::::::::::::::::::::::::::::::::::
NP_005 ERSPAKRGRKSATVKPGAVGAGEFVSPCESGDNTGEPSALEEQRGPLPLNKTLFLGYAFL
        1680      1690      1700      1710      1720      1730     

     1740      1750      1760      1770      1780      1790        
pF1KSD LTMATTSDKLASRSKLPDGPTGSSEEEEEFLEIPPFNKQYTESQLRAGAGYILEDFNEAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LTMATTSDKLASRSKLPDGPTGSSEEEEEFLEIPPFNKQYTESQLRAGAGYILEDFNEAQ
        1740      1750      1760      1770      1780      1790     

     1800      1810      1820      1830      1840      1850        
pF1KSD CNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLE
        1800      1810      1820      1830      1840      1850     

     1860      1870      1880      1890      1900      1910        
pF1KSD EQRILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EQRILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALG
        1860      1870      1880      1890      1900      1910     

     1920      1930      1940      1950      1960      1970     
pF1KSD VFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYKHDYVSH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYKHDYVSH
        1920      1930      1940      1950      1960      1970  

>>XP_011520288 (OMIM: 605230) PREDICTED: tumor suppresso  (1700 aa)
 initn: 11127 init1: 11127 opt: 11127  Z-score: 6827.2  bits: 1276.5 E(85289):    0
Smith-Waterman score: 11127; 100.0% identity (100.0% similar) in 1696 aa overlap (1-1696:1-1696)

               10        20        30        40        50        60
pF1KSD MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD NPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVADPVDSSNLDTCGSISQVIEQLPQPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVADPVDSSNLDTCGSISQVIEQLPQPN
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD RTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKD
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD IPVTAQPSKDVHVVKEQNPPPARSEDMPFSPKASVAAMEAKEQLSAQELMESGLQIQKSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPVTAQPSKDVHVVKEQNPPPARSEDMPFSPKASVAAMEAKEQLSAQELMESGLQIQKSP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD EPEVLSTQEDLFDQSNKTVSSDGCSTPSREEGGCSLASTPATTLHLLQLSGQRSLVQDSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPEVLSTQEDLFDQSNKTVSSDGCSTPSREEGGCSLASTPATTLHLLQLSGQRSLVQDSL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD STNSSDLVAPSPDAFRSTPFIVPSSPTEQEGRQDKPMDTSVLSEEGGEPFQKKLQSGEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STNSSDLVAPSPDAFRSTPFIVPSSPTEQEGRQDKPMDTSVLSEEGGEPFQKKLQSGEPV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD ELENPPLLPESTVSPQASTPISQSTPVFPPGSLPIPSQPQFSHDIFIPSPSLEEQSNDGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELENPPLLPESTVSPQASTPISQSTPVFPPGSLPIPSQPQFSHDIFIPSPSLEEQSNDGK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD KDGDMHSSSLTVECSKTSEIEPKNSPEDLGLSLTGDSCKLMLSTSEYSQSPKMESLSSHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDGDMHSSSLTVECSKTSEIEPKNSPEDLGLSLTGDSCKLMLSTSEYSQSPKMESLSSHR
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD IDEDGENTQIEDTEPMSPVLNSKFVPAENDSILMNPAQDGEVQLSQNDDKTKGDDTDTRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDEDGENTQIEDTEPMSPVLNSKFVPAENDSILMNPAQDGEVQLSQNDDKTKGDDTDTRD
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD DISILATGCKGREETVAEDVCIDLTCDSGSQAVPSPATRSEALSSVLDQEEAMEIKEHHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DISILATGCKGREETVAEDVCIDLTCDSGSQAVPSPATRSEALSSVLDQEEAMEIKEHHP
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD EEGSSGSEVEEIPETPCESQGEELKEENMESVPLHLSLTETQSQGLCLQKEMPKKECSEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEGSSGSEVEEIPETPCESQGEELKEENMESVPLHLSLTETQSQGLCLQKEMPKKECSEA
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD MEVETSVISIDSPQKLAILDQELEHKEQEAWEEATSEDSSVVIVDVKEPSPRVDVSCEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEVETSVISIDSPQKLAILDQELEHKEQEAWEEATSEDSSVVIVDVKEPSPRVDVSCEPL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD EGVEKCSDSQSWEDIAPEIEPCAENRLDTKEEKSVEYEGDLKSGTAETEPVEQDSSQPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGVEKCSDSQSWEDIAPEIEPCAENRLDTKEEKSVEYEGDLKSGTAETEPVEQDSSQPSL
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD PLVRADDPLRLDQELQQPQTQEKTSNSLTEDSKMANAKQLSSDAEAQKLGKPSAHASQSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLVRADDPLRLDQELQQPQTQEKTSNSLTEDSKMANAKQLSSDAEAQKLGKPSAHASQSF
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD CESSSETPFHFTLPKEGDIIPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CESSSETPFHFTLPKEGDIIPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDV
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD MSESMVETHDPILGSGKGDSGAAPDVDDKLCLRMKLVSPETEASEESLQFNLEKPATGER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSESMVETHDPILGSGKGDSGAAPDVDDKLCLRMKLVSPETEASEESLQFNLEKPATGER
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD KNGSTAVAESVASPQKTMSVLSCICEARQENEARSEDPPTTPIRGNLLHFPSSQGEEEKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNGSTAVAESVASPQKTMSVLSCICEARQENEARSEDPPTTPIRGNLLHFPSSQGEEEKE
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD KLEGDHTIRQSQQPMKPISPVKDPVSPASQKMVIQGPSSPQGEAMVTDVLEDQKEGRSTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLEGDHTIRQSQQPMKPISPVKDPVSPASQKMVIQGPSSPQGEAMVTDVLEDQKEGRSTN
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD KENPSKALIERPSQNNIGIQTMECSLRVPETVSAATQTIKNVCEQGTSTVDQNFGKQDAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KENPSKALIERPSQNNIGIQTMECSLRVPETVSAATQTIKNVCEQGTSTVDQNFGKQDAT
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KSD VQTERGSGEKPVSAPGDDTESLHSQGEEEFDMPQPPHGHVLHRHMRTIREVRTLVTRVIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQTERGSGEKPVSAPGDDTESLHSQGEEEFDMPQPPHGHVLHRHMRTIREVRTLVTRVIT
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KSD DVYYVDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSLHRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVYYVDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSLHRT
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KSD SSGTSLSAMHSSGSSGKGAGPLRGKTSGTEPADFALPSSRGGPGKLSPRKGVSQTGTPVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSGTSLSAMHSSGSSGKGAGPLRGKTSGTEPADFALPSSRGGPGKLSPRKGVSQTGTPVC
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KSD EEDGDAGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETAVPGPLGIEDISPNLSPDDKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEDGDAGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETAVPGPLGIEDISPNLSPDDKS
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KSD FSRVVPRVPDSTRRTDVGAGALRRSDSPEIPFQAAAGPSDGLDASSPGNSFVGLRVVAKW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSRVVPRVPDSTRRTDVGAGALRRSDSPEIPFQAAAGPSDGLDASSPGNSFVGLRVVAKW
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KSD SSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSA
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KSD GVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTKAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTKAA
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KSD DISLDNLVEGKRKRRSNVSSPATPTASSSSSTTPTRKITESPRASMGVLSGKRKLITSEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DISLDNLVEGKRKRRSNVSSPATPTASSSSSTTPTRKITESPRASMGVLSGKRKLITSEE
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KSD ERSPAKRGRKSATVKPVGAGEFVSPCESGDNTGEPSALEEQRGPLPLNKTLFLGYAFLLT
       ::::::::::::::::                                            
XP_011 ERSPAKRGRKSATVKPGRHA                                        
             1690      1700                                        

>>XP_011520287 (OMIM: 605230) PREDICTED: tumor suppresso  (1927 aa)
 initn: 10848 init1: 8949 opt: 8964  Z-score: 5501.0  bits: 1031.3 E(85289):    0
Smith-Waterman score: 12565; 97.4% identity (97.4% similar) in 1977 aa overlap (1-1975:1-1927)

               10        20        30        40        50        60
pF1KSD MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD NPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVADPVDSSNLDTCGSISQVIEQLPQPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVADPVDSSNLDTCGSISQVIEQLPQPN
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD RTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKD
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD IPVTAQPSKDVHVVKEQNPPPARSEDMPFSPKASVAAMEAKEQLSAQELMESGLQIQKSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPVTAQPSKDVHVVKEQNPPPARSEDMPFSPKASVAAMEAKEQLSAQELMESGLQIQKSP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD EPEVLSTQEDLFDQSNKTVSSDGCSTPSREEGGCSLASTPATTLHLLQLSGQRSLVQDSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPEVLSTQEDLFDQSNKTVSSDGCSTPSREEGGCSLASTPATTLHLLQLSGQRSLVQDSL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD STNSSDLVAPSPDAFRSTPFIVPSSPTEQEGRQDKPMDTSVLSEEGGEPFQKKLQSGEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STNSSDLVAPSPDAFRSTPFIVPSSPTEQEGRQDKPMDTSVLSEEGGEPFQKKLQSGEPV
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD ELENPPLLPESTVSPQASTPISQSTPVFPPGSLPIPSQPQFSHDIFIPSPSLEEQSNDGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELENPPLLPESTVSPQASTPISQSTPVFPPGSLPIPSQPQFSHDIFIPSPSLEEQSNDGK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD KDGDMHSSSLTVECSKTSEIEPKNSPEDLGLSLTGDSCKLMLSTSEYSQSPKMESLSSHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDGDMHSSSLTVECSKTSEIEPKNSPEDLGLSLTGDSCKLMLSTSEYSQSPKMESLSSHR
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD IDEDGENTQIEDTEPMSPVLNSKFVPAENDSILMNPAQDGEVQLSQNDDKTKGDDTDTRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDEDGENTQIEDTEPMSPVLNSKFVPAENDSILMNPAQDGEVQLSQNDDKTKGDDTDTRD
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD DISILATGCKGREETVAEDVCIDLTCDSGSQAVPSPATRSEALSSVLDQEEAMEIKEHHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DISILATGCKGREETVAEDVCIDLTCDSGSQAVPSPATRSEALSSVLDQEEAMEIKEHHP
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD EEGSSGSEVEEIPETPCESQGEELKEENMESVPLHLSLTETQSQGLCLQKEMPKKECSEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEGSSGSEVEEIPETPCESQGEELKEENMESVPLHLSLTETQSQGLCLQKEMPKKECSEA
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD MEVETSVISIDSPQKLAILDQELEHKEQEAWEEATSEDSSVVIVDVKEPSPRVDVSCEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEVETSVISIDSPQKLAILDQELEHKEQEAWEEATSEDSSVVIVDVKEPSPRVDVSCEPL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD EGVEKCSDSQSWEDIAPEIEPCAENRLDTKEEKSVEYEGDLKSGTAETEPVEQDSSQPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGVEKCSDSQSWEDIAPEIEPCAENRLDTKEEKSVEYEGDLKSGTAETEPVEQDSSQPSL
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD PLVRADDPLRLDQELQQPQTQEKTSNSLTEDSKMANAKQLSSDAEAQKLGKPSAHASQSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLVRADDPLRLDQELQQPQTQEKTSNSLTEDSKMANAKQLSSDAEAQKLGKPSAHASQSF
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD CESSSETPFHFTLPKEGDIIPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CESSSETPFHFTLPKEGDIIPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDV
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD MSESMVETHDPILGSGKGDSGAAPDVDDKLCLRMKLVSPETEASEESLQFNLEKPATGER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSESMVETHDPILGSGKGDSGAAPDVDDKLCLRMKLVSPETEASEESLQFNLEKPATGER
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD KNGSTAVAESVASPQKTMSVLSCICEARQENEARSEDPPTTPIRGNLLHFPSSQGEEEKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNGSTAVAESVASPQKTMSVLSCICEARQENEARSEDPPTTPIRGNLLHFPSSQGEEEKE
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD KLEGDHTIRQSQQPMKPISPVKDPVSPASQKMVIQGPSSPQGEAMVTDVLEDQKEGRSTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLEGDHTIRQSQQPMKPISPVKDPVSPASQKMVIQGPSSPQGEAMVTDVLEDQKEGRSTN
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD KENPSKALIERPSQNNIGIQTMECSLRVPETVSAATQTIKNVCEQGTSTVDQNFGKQDAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KENPSKALIERPSQNNIGIQTMECSLRVPETVSAATQTIKNVCEQGTSTVDQNFGKQDAT
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KSD VQTERGSGEKPVSAPGDDTESLHSQGEEEFDMPQPPHGHVLHRHMRTIREVRTLVTRVIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQTERGSGEKPVSAPGDDTESLHSQGEEEFDMPQPPHGHVLHRHMRTIREVRTLVTRVIT
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KSD DVYYVDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSLHRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVYYVDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSLHRT
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KSD SSGTSLSAMHSSGSSGKGAGPLRGKTSGTEPADFALPSSRGGPGKLSPRKGVSQTGTPVC
       ::::::::::::::::::::::::::::::::::::::::::::::              
XP_011 SSGTSLSAMHSSGSSGKGAGPLRGKTSGTEPADFALPSSRGGPGKL--------------
             1330      1340      1350      1360                    

             1390      1400      1410      1420      1430      1440
pF1KSD EEDGDAGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETAVPGPLGIEDISPNLSPDDKS
                                           ::::::::::::::::::::::::
XP_011 ------------------------------------RETAVPGPLGIEDISPNLSPDDKS
                                           1370      1380      1390

             1450      1460      1470      1480      1490      1500
pF1KSD FSRVVPRVPDSTRRTDVGAGALRRSDSPEIPFQAAAGPSDGLDASSPGNSFVGLRVVAKW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSRVVPRVPDSTRRTDVGAGALRRSDSPEIPFQAAAGPSDGLDASSPGNSFVGLRVVAKW
             1400      1410      1420      1430      1440      1450

             1510      1520      1530      1540      1550      1560
pF1KSD SSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSA
             1460      1470      1480      1490      1500      1510

             1570      1580      1590      1600      1610      1620
pF1KSD GVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTKAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTKAA
             1520      1530      1540      1550      1560      1570

             1630      1640      1650      1660      1670      1680
pF1KSD DISLDNLVEGKRKRRSNVSSPATPTASSSSSTTPTRKITESPRASMGVLSGKRKLITSEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DISLDNLVEGKRKRRSNVSSPATPTASSSSSTTPTRKITESPRASMGVLSGKRKLITSEE
             1580      1590      1600      1610      1620      1630

             1690        1700      1710      1720      1730        
pF1KSD ERSPAKRGRKSATVKP--VGAGEFVSPCESGDNTGEPSALEEQRGPLPLNKTLFLGYAFL
       ::::::::::::::::  ::::::::::::::::::::::::::::::::::::::::::
XP_011 ERSPAKRGRKSATVKPGAVGAGEFVSPCESGDNTGEPSALEEQRGPLPLNKTLFLGYAFL
             1640      1650      1660      1670      1680      1690

     1740      1750      1760      1770      1780      1790        
pF1KSD LTMATTSDKLASRSKLPDGPTGSSEEEEEFLEIPPFNKQYTESQLRAGAGYILEDFNEAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTMATTSDKLASRSKLPDGPTGSSEEEEEFLEIPPFNKQYTESQLRAGAGYILEDFNEAQ
             1700      1710      1720      1730      1740      1750

     1800      1810      1820      1830      1840      1850        
pF1KSD CNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLE
             1760      1770      1780      1790      1800      1810

     1860      1870      1880      1890      1900      1910        
pF1KSD EQRILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQRILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALG
             1820      1830      1840      1850      1860      1870

     1920      1930      1940      1950      1960      1970     
pF1KSD VFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYKHDYVSH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYKHDYVSH
             1880      1890      1900      1910      1920       

>>XP_016878022 (OMIM: 605230) PREDICTED: tumor suppresso  (1017 aa)
 initn: 4847 init1: 4847 opt: 6742  Z-score: 4143.7  bits: 779.2 E(85289):    0
Smith-Waterman score: 6742; 99.8% identity (99.8% similar) in 1017 aa overlap (961-1975:1-1017)

              940       950       960       970       980       990
pF1KSD IGHLKLEPKRHSTPIGISNYPESTIATSDVMSESMVETHDPILGSGKGDSGAAPDVDDKL
                                     ::::::::::::::::::::::::::::::
XP_016                               MSESMVETHDPILGSGKGDSGAAPDVDDKL
                                             10        20        30

             1000      1010      1020      1030      1040      1050
pF1KSD CLRMKLVSPETEASEESLQFNLEKPATGERKNGSTAVAESVASPQKTMSVLSCICEARQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLRMKLVSPETEASEESLQFNLEKPATGERKNGSTAVAESVASPQKTMSVLSCICEARQE
               40        50        60        70        80        90

             1060      1070      1080      1090      1100      1110
pF1KSD NEARSEDPPTTPIRGNLLHFPSSQGEEEKEKLEGDHTIRQSQQPMKPISPVKDPVSPASQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEARSEDPPTTPIRGNLLHFPSSQGEEEKEKLEGDHTIRQSQQPMKPISPVKDPVSPASQ
              100       110       120       130       140       150

             1120      1130      1140      1150      1160      1170
pF1KSD KMVIQGPSSPQGEAMVTDVLEDQKEGRSTNKENPSKALIERPSQNNIGIQTMECSLRVPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KMVIQGPSSPQGEAMVTDVLEDQKEGRSTNKENPSKALIERPSQNNIGIQTMECSLRVPE
              160       170       180       190       200       210

             1180      1190      1200      1210      1220      1230
pF1KSD TVSAATQTIKNVCEQGTSTVDQNFGKQDATVQTERGSGEKPVSAPGDDTESLHSQGEEEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVSAATQTIKNVCEQGTSTVDQNFGKQDATVQTERGSGEKPVSAPGDDTESLHSQGEEEF
              220       230       240       250       260       270

             1240      1250      1260      1270      1280      1290
pF1KSD DMPQPPHGHVLHRHMRTIREVRTLVTRVITDVYYVDGTEVERKVTEETEEPIVECQECET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DMPQPPHGHVLHRHMRTIREVRTLVTRVITDVYYVDGTEVERKVTEETEEPIVECQECET
              280       290       300       310       320       330

             1300      1310      1320      1330      1340      1350
pF1KSD EVSPSQTGGSSGDLGDISSFSSKASSLHRTSSGTSLSAMHSSGSSGKGAGPLRGKTSGTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVSPSQTGGSSGDLGDISSFSSKASSLHRTSSGTSLSAMHSSGSSGKGAGPLRGKTSGTE
              340       350       360       370       380       390

             1360      1370      1380      1390      1400      1410
pF1KSD PADFALPSSRGGPGKLSPRKGVSQTGTPVCEEDGDAGLGIRQGGKAPVTPRGRGRRGRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PADFALPSSRGGPGKLSPRKGVSQTGTPVCEEDGDAGLGIRQGGKAPVTPRGRGRRGRPP
              400       410       420       430       440       450

             1420      1430      1440      1450      1460      1470
pF1KSD SRTTGTRETAVPGPLGIEDISPNLSPDDKSFSRVVPRVPDSTRRTDVGAGALRRSDSPEI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRTTGTRETAVPGPLGIEDISPNLSPDDKSFSRVVPRVPDSTRRTDVGAGALRRSDSPEI
              460       470       480       490       500       510

             1480      1490      1500      1510      1520      1530
pF1KSD PFQAAAGPSDGLDASSPGNSFVGLRVVAKWSSNGYFYSGKITRDVGAGKYKLLFDDGYEC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFQAAAGPSDGLDASSPGNSFVGLRVVAKWSSNGYFYSGKITRDVGAGKYKLLFDDGYEC
              520       530       540       550       560       570

             1540      1550      1560      1570      1580      1590
pF1KSD DVLGKDILLCDPIPLDTEVTALSEDEYFSAGVVKGHRKESGELYYSIEKEGQRKWYKRMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVLGKDILLCDPIPLDTEVTALSEDEYFSAGVVKGHRKESGELYYSIEKEGQRKWYKRMA
              580       590       600       610       620       630

             1600      1610      1620      1630      1640      1650
pF1KSD VILSLEQGNRLREQYGLGPYEAVTPLTKAADISLDNLVEGKRKRRSNVSSPATPTASSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VILSLEQGNRLREQYGLGPYEAVTPLTKAADISLDNLVEGKRKRRSNVSSPATPTASSSS
              640       650       660       670       680       690

             1660      1670      1680      1690        1700        
pF1KSD STTPTRKITESPRASMGVLSGKRKLITSEEERSPAKRGRKSATVKP--VGAGEFVSPCES
       ::::::::::::::::::::::::::::::::::::::::::::::  ::::::::::::
XP_016 STTPTRKITESPRASMGVLSGKRKLITSEEERSPAKRGRKSATVKPGAVGAGEFVSPCES
              700       710       720       730       740       750

     1710      1720      1730      1740      1750      1760        
pF1KSD GDNTGEPSALEEQRGPLPLNKTLFLGYAFLLTMATTSDKLASRSKLPDGPTGSSEEEEEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDNTGEPSALEEQRGPLPLNKTLFLGYAFLLTMATTSDKLASRSKLPDGPTGSSEEEEEF
              760       770       780       790       800       810

     1770      1780      1790      1800      1810      1820        
pF1KSD LEIPPFNKQYTESQLRAGAGYILEDFNEAQCNTAYQCLLIADQHCRTRKYFLCLASGIPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEIPPFNKQYTESQLRAGAGYILEDFNEAQCNTAYQCLLIADQHCRTRKYFLCLASGIPC
              820       830       840       850       860       870

     1830      1840      1850      1860      1870      1880        
pF1KSD VSHVWVHDSCHANQLQNYRNYLLPAGYSLEEQRILDWQPRENPFQNLKVLLVSDQQQNFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSHVWVHDSCHANQLQNYRNYLLPAGYSLEEQRILDWQPRENPFQNLKVLLVSDQQQNFL
              880       890       900       910       920       930

     1890      1900      1910      1920      1930      1940        
pF1KSD ELWSEILMTGGAASVKQHHSSAHNKDIALGVFDVVVTDPSCPASVLKCAEALQLPVVSQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELWSEILMTGGAASVKQHHSSAHNKDIALGVFDVVVTDPSCPASVLKCAEALQLPVVSQE
              940       950       960       970       980       990

     1950      1960      1970     
pF1KSD WVIQCLIVGERIGFKQHPKYKHDYVSH
       :::::::::::::::::::::::::::
XP_016 WVIQCLIVGERIGFKQHPKYKHDYVSH
             1000      1010       




1975 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 08:21:06 2016 done: Thu Nov  3 08:21:08 2016
 Total Scan time: 19.700 Total Display time:  0.570

Function used was FASTA [36.3.4 Apr, 2011]
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