Result of FASTA (omim) for pF1KSDA1720
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA1720, 393 aa
  1>>>pF1KSDA1720 393 - 393 aa - 393 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.1946+/-0.000318; mu= 5.5499+/- 0.020
 mean_var=189.0644+/-38.207, 0's: 0 Z-trim(122.2): 37  B-trim: 939 in 2/59
 Lambda= 0.093276
 statistics sampled from 39888 (39942) to 39888 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.774), E-opt: 0.2 (0.468), width:  16
 Scan time: 10.130

The best scores are:                                      opt bits E(85289)
XP_011532555 (OMIM: 605612) PREDICTED: SH3 domain- ( 368)  700 106.0 1.5e-22
NP_004835 (OMIM: 605612) SH3 domain-binding protei ( 455)  698 105.8 2.1e-22
XP_011532553 (OMIM: 605612) PREDICTED: SH3 domain- ( 415)  648 99.0 2.1e-20
XP_016863010 (OMIM: 605612) PREDICTED: SH3 domain- ( 442)  639 97.9 5.2e-20
XP_016863011 (OMIM: 605612) PREDICTED: SH3 domain- ( 298)  336 57.0 7.2e-08
XP_016863013 (OMIM: 605612) PREDICTED: SH3 domain- ( 298)  336 57.0 7.2e-08
XP_016863012 (OMIM: 605612) PREDICTED: SH3 domain- ( 298)  336 57.0 7.2e-08
NP_001018009 (OMIM: 605612) SH3 domain-binding pro ( 298)  336 57.0 7.2e-08
XP_016863014 (OMIM: 605612) PREDICTED: SH3 domain- ( 298)  336 57.0 7.2e-08


>>XP_011532555 (OMIM: 605612) PREDICTED: SH3 domain-bind  (368 aa)
 initn: 386 init1: 355 opt: 700  Z-score: 525.8  bits: 106.0 E(85289): 1.5e-22
Smith-Waterman score: 711; 38.6% identity (69.0% similar) in 339 aa overlap (52-389:37-346)

              30        40        50        60        70        80 
pF1KSD VVEDEVPRSPVAEEPGGGGSSSSEAKLSPREEEELDPRIQEELEHLNQASEEINQVELQL
                                     ::::.::::: :::.:::....::. : .:
XP_011 RSRSEEPAEILPPARDEEEEEEEGMEQGLEEEEEVDPRIQGELEKLNQSTDDINRRETEL
         10        20        30        40        50        60      

              90       100       110       120       130       140 
pF1KSD DEARTTYRRILQESARKLNTQGSHLGSCIEKARPYYEARRLAKEAQQETQKAALRYERAV
       ..::  .: .: :.. ::.   ...:. .: ..::.::::.:..:: :.:::.  ..::.
XP_011 EDARQKFRSVLVEATVKLDELVKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRAT
         70        80        90       100       110       120      

             150       160        170       180       190       200
pF1KSD SMHNAAREMVFVAEQGVMADKNR-LDPTWQEMLNHATCKVNEAEEERLRGEREHQRVTRL
        .  ::.: . .::: .. : .: .: .::::::::: .: :::. . :.:  :....  
XP_011 EVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAAR
        130       140       150       160       170       180      

              210       220       230       240       250       260
pF1KSD CQQAEARVQALQKTLRRAIGKSRPYFELKAQFSQILEEHKAKVTELEQQVAQAKTRYSVA
        . : .:.. :.: :.:::.::.:::::::..   ::. :  : .:. ... :: .:..:
XP_011 YNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLTLAKGEYKMA
        190       200       210       220       230       240      

              270       280       290       300       310       320
pF1KSD LRNLEQISEQIHARRRGGLPPHPLGPRRSSPVGAEAGPEDMEDGDSGIEGAEGAGLEEGS
       :.:::.::..:: :::..     .::: .  ::::..  ..::                 
XP_011 LKNLEMISDEIHERRRSS----AMGPR-GCGVGAEGSSTSVEDL----------------
        250       260            270       280                     

              330       340       350       360       370       380
pF1KSD SLGPGPAPDTDTLSLLSLRTVASDLQKCDSVEHLRGLSDHVSLDGQELGTRSGGRRGSDG
          ::  :. :..:  . :. ... .  :.... ::::   : .:.  ...: .  . .:
XP_011 ---PGSKPEPDAIS--GDRAEGAENKTSDKANNNRGLS---SSSGSGGSSKSQSSTSPEG
            290         300       310          320       330       

              390                     
pF1KSD GARGGRHQRSVSL                  
        :  .: ..                      
XP_011 QALENRMKQLSLQCSKGRDGIIADIKMVQIG
       340       350       360        

>>NP_004835 (OMIM: 605612) SH3 domain-binding protein 5   (455 aa)
 initn: 386 init1: 355 opt: 698  Z-score: 523.0  bits: 105.8 E(85289): 2.1e-22
Smith-Waterman score: 698; 45.1% identity (76.3% similar) in 253 aa overlap (52-303:37-284)

              30        40        50        60        70        80 
pF1KSD VVEDEVPRSPVAEEPGGGGSSSSEAKLSPREEEELDPRIQEELEHLNQASEEINQVELQL
                                     ::::.::::: :::.:::....::. : .:
NP_004 RSRSEEPAEILPPARDEEEEEEEGMEQGLEEEEEVDPRIQGELEKLNQSTDDINRRETEL
         10        20        30        40        50        60      

              90       100       110       120       130       140 
pF1KSD DEARTTYRRILQESARKLNTQGSHLGSCIEKARPYYEARRLAKEAQQETQKAALRYERAV
       ..::  .: .: :.. ::.   ...:. .: ..::.::::.:..:: :.:::.  ..::.
NP_004 EDARQKFRSVLVEATVKLDELVKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRAT
         70        80        90       100       110       120      

             150       160        170       180       190       200
pF1KSD SMHNAAREMVFVAEQGVMADKNR-LDPTWQEMLNHATCKVNEAEEERLRGEREHQRVTRL
        .  ::.: . .::: .. : .: .: .::::::::: .: :::. . :.:  :....  
NP_004 EVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAAR
        130       140       150       160       170       180      

              210       220       230       240       250       260
pF1KSD CQQAEARVQALQKTLRRAIGKSRPYFELKAQFSQILEEHKAKVTELEQQVAQAKTRYSVA
        . : .:.. :.: :.:::.::.:::::::..   ::. :  : .:. ... :: .:..:
NP_004 YNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLTLAKGEYKMA
        190       200       210       220       230       240      

              270       280       290       300       310       320
pF1KSD LRNLEQISEQIHARRRGGLPPHPLGPRRSSPVGAEAGPEDMEDGDSGIEGAEGAGLEEGS
       :.:::.::..:: :::..     .::: .  ::::..  ..::                 
NP_004 LKNLEMISDEIHERRRSS----AMGPR-GCGVGAEGSSTSVEDLPGSKPEPDAISVASEA
        250       260            270       280       290       300 

              330       340       350       360       370       380
pF1KSD SLGPGPAPDTDTLSLLSLRTVASDLQKCDSVEHLRGLSDHVSLDGQELGTRSGGRRGSDG
                                                                   
NP_004 FEDDSCSNFVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVVRPGSLDLPSPVSLSEFGMM
             310       320       330       340       350       360 

>>XP_011532553 (OMIM: 605612) PREDICTED: SH3 domain-bind  (415 aa)
 initn: 386 init1: 355 opt: 648  Z-score: 487.2  bits: 99.0 E(85289): 2.1e-20
Smith-Waterman score: 648; 43.7% identity (75.5% similar) in 245 aa overlap (60-303:5-244)

      30        40        50        60        70        80         
pF1KSD SPVAEEPGGGGSSSSEAKLSPREEEELDPRIQEELEHLNQASEEINQVELQLDEARTTYR
                                     :: :::.:::....::. : .:..::  .:
XP_011                           MLLAIQGELEKLNQSTDDINRRETELEDARQKFR
                                         10        20        30    

      90       100       110       120       130       140         
pF1KSD RILQESARKLNTQGSHLGSCIEKARPYYEARRLAKEAQQETQKAALRYERAVSMHNAARE
        .: :.. ::.   ...:. .: ..::.::::.:..:: :.:::.  ..::. .  ::.:
XP_011 SVLVEATVKLDELVKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRATEVLRAAKE
           40        50        60        70        80        90    

     150       160        170       180       190       200        
pF1KSD MVFVAEQGVMADKNR-LDPTWQEMLNHATCKVNEAEEERLRGEREHQRVTRLCQQAEARV
        . .::: .. : .: .: .::::::::: .: :::. . :.:  :....   . : .:.
XP_011 TISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRM
          100       110       120       130       140       150    

      210       220       230       240       250       260        
pF1KSD QALQKTLRRAIGKSRPYFELKAQFSQILEEHKAKVTELEQQVAQAKTRYSVALRNLEQIS
       . :.: :.:::.::.:::::::..   ::. :  : .:. ... :: .:..::.:::.::
XP_011 RQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLTLAKGEYKMALKNLEMIS
          160       170       180       190       200       210    

      270       280       290       300       310       320        
pF1KSD EQIHARRRGGLPPHPLGPRRSSPVGAEAGPEDMEDGDSGIEGAEGAGLEEGSSLGPGPAP
       ..:: :::..     .::: .  ::::..  ..::                         
XP_011 DEIHERRRSS----AMGPR-GCGVGAEGSSTSVEDLPGSKPEPDAISVASEAFEDDSCSN
          220            230       240       250       260         

      330       340       350       360       370       380        
pF1KSD DTDTLSLLSLRTVASDLQKCDSVEHLRGLSDHVSLDGQELGTRSGGRRGSDGGARGGRHQ
                                                                   
XP_011 FVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVVRPGSLDLPSPVSLSEFGMMFPVLGPRS
     270       280       290       300       310       320         

>>XP_016863010 (OMIM: 605612) PREDICTED: SH3 domain-bind  (442 aa)
 initn: 386 init1: 355 opt: 639  Z-score: 480.3  bits: 97.9 E(85289): 5.2e-20
Smith-Waterman score: 639; 43.4% identity (75.6% similar) in 242 aa overlap (63-303:35-271)

             40        50        60        70        80        90  
pF1KSD AEEPGGGGSSSSEAKLSPREEEELDPRIQEELEHLNQASEEINQVELQLDEARTTYRRIL
                                     :::.:::....::. : .:..::  .: .:
XP_016 TLSKGTPSRKWFQKCRHSFAFLVKPQLFAGELEKLNQSTDDINRRETELEDARQKFRSVL
           10        20        30        40        50        60    

            100       110       120       130       140       150  
pF1KSD QESARKLNTQGSHLGSCIEKARPYYEARRLAKEAQQETQKAALRYERAVSMHNAAREMVF
        :.. ::.   ...:. .: ..::.::::.:..:: :.:::.  ..::. .  ::.: . 
XP_016 VEATVKLDELVKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRATEVLRAAKETIS
           70        80        90       100       110       120    

            160        170       180       190       200       210 
pF1KSD VAEQGVMADKNR-LDPTWQEMLNHATCKVNEAEEERLRGEREHQRVTRLCQQAEARVQAL
       .::: .. : .: .: .::::::::: .: :::. . :.:  :....   . : .:.. :
XP_016 LAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQL
          130       140       150       160       170       180    

             220       230       240       250       260       270 
pF1KSD QKTLRRAIGKSRPYFELKAQFSQILEEHKAKVTELEQQVAQAKTRYSVALRNLEQISEQI
       .: :.:::.::.:::::::..   ::. :  : .:. ... :: .:..::.:::.::..:
XP_016 EKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLTLAKGEYKMALKNLEMISDEI
          190       200       210       220       230       240    

             280       290       300       310       320       330 
pF1KSD HARRRGGLPPHPLGPRRSSPVGAEAGPEDMEDGDSGIEGAEGAGLEEGSSLGPGPAPDTD
       : :::..     .::: .  ::::..  ..::                            
XP_016 HERRRSS----AMGPR-GCGVGAEGSSTSVEDLPGSKPEPDAISVASEAFEDDSCSNFVS
          250            260       270       280       290         

             340       350       360       370       380       390 
pF1KSD TLSLLSLRTVASDLQKCDSVEHLRGLSDHVSLDGQELGTRSGGRRGSDGGARGGRHQRSV
                                                                   
XP_016 EDDSETQSVSSFSSGPTSPSEMPDQFPAVVRPGSLDLPSPVSLSEFGMMFPVLGPRSECS
     300       310       320       330       340       350         

>>XP_016863011 (OMIM: 605612) PREDICTED: SH3 domain-bind  (298 aa)
 initn: 336 init1: 305 opt: 336  Z-score: 262.3  bits: 57.0 E(85289): 7.2e-08
Smith-Waterman score: 336; 44.7% identity (74.2% similar) in 132 aa overlap (172-303:1-127)

             150       160       170       180       190       200 
pF1KSD SMHNAAREMVFVAEQGVMADKNRLDPTWQEMLNHATCKVNEAEEERLRGEREHQRVTRLC
                                     :::::: .: :::. . :.:  :....   
XP_016                               MLNHATQRVMEAEQTKTRSELVHKETAARY
                                             10        20        30

             210       220       230       240       250       260 
pF1KSD QQAEARVQALQKTLRRAIGKSRPYFELKAQFSQILEEHKAKVTELEQQVAQAKTRYSVAL
       . : .:.. :.: :.:::.::.:::::::..   ::. :  : .:. ... :: .:..::
XP_016 NAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLTLAKGEYKMAL
               40        50        60        70        80        90

             270       280       290       300       310       320 
pF1KSD RNLEQISEQIHARRRGGLPPHPLGPRRSSPVGAEAGPEDMEDGDSGIEGAEGAGLEEGSS
       .:::.::..:: :::..     .::: .  ::::..  ..::                  
XP_016 KNLEMISDEIHERRRSS----AMGPR-GCGVGAEGSSTSVEDLPGSKPEPDAISVASEAF
              100           110        120       130       140     

             330       340       350       360       370       380 
pF1KSD LGPGPAPDTDTLSLLSLRTVASDLQKCDSVEHLRGLSDHVSLDGQELGTRSGGRRGSDGG
                                                                   
XP_016 EDDSCSNFVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVVRPGSLDLPSPVSLSEFGMMF
         150       160       170       180       190       200     

>>XP_016863013 (OMIM: 605612) PREDICTED: SH3 domain-bind  (298 aa)
 initn: 336 init1: 305 opt: 336  Z-score: 262.3  bits: 57.0 E(85289): 7.2e-08
Smith-Waterman score: 336; 44.7% identity (74.2% similar) in 132 aa overlap (172-303:1-127)

             150       160       170       180       190       200 
pF1KSD SMHNAAREMVFVAEQGVMADKNRLDPTWQEMLNHATCKVNEAEEERLRGEREHQRVTRLC
                                     :::::: .: :::. . :.:  :....   
XP_016                               MLNHATQRVMEAEQTKTRSELVHKETAARY
                                             10        20        30

             210       220       230       240       250       260 
pF1KSD QQAEARVQALQKTLRRAIGKSRPYFELKAQFSQILEEHKAKVTELEQQVAQAKTRYSVAL
       . : .:.. :.: :.:::.::.:::::::..   ::. :  : .:. ... :: .:..::
XP_016 NAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLTLAKGEYKMAL
               40        50        60        70        80        90

             270       280       290       300       310       320 
pF1KSD RNLEQISEQIHARRRGGLPPHPLGPRRSSPVGAEAGPEDMEDGDSGIEGAEGAGLEEGSS
       .:::.::..:: :::..     .::: .  ::::..  ..::                  
XP_016 KNLEMISDEIHERRRSS----AMGPR-GCGVGAEGSSTSVEDLPGSKPEPDAISVASEAF
              100           110        120       130       140     

             330       340       350       360       370       380 
pF1KSD LGPGPAPDTDTLSLLSLRTVASDLQKCDSVEHLRGLSDHVSLDGQELGTRSGGRRGSDGG
                                                                   
XP_016 EDDSCSNFVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVVRPGSLDLPSPVSLSEFGMMF
         150       160       170       180       190       200     

>>XP_016863012 (OMIM: 605612) PREDICTED: SH3 domain-bind  (298 aa)
 initn: 336 init1: 305 opt: 336  Z-score: 262.3  bits: 57.0 E(85289): 7.2e-08
Smith-Waterman score: 336; 44.7% identity (74.2% similar) in 132 aa overlap (172-303:1-127)

             150       160       170       180       190       200 
pF1KSD SMHNAAREMVFVAEQGVMADKNRLDPTWQEMLNHATCKVNEAEEERLRGEREHQRVTRLC
                                     :::::: .: :::. . :.:  :....   
XP_016                               MLNHATQRVMEAEQTKTRSELVHKETAARY
                                             10        20        30

             210       220       230       240       250       260 
pF1KSD QQAEARVQALQKTLRRAIGKSRPYFELKAQFSQILEEHKAKVTELEQQVAQAKTRYSVAL
       . : .:.. :.: :.:::.::.:::::::..   ::. :  : .:. ... :: .:..::
XP_016 NAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLTLAKGEYKMAL
               40        50        60        70        80        90

             270       280       290       300       310       320 
pF1KSD RNLEQISEQIHARRRGGLPPHPLGPRRSSPVGAEAGPEDMEDGDSGIEGAEGAGLEEGSS
       .:::.::..:: :::..     .::: .  ::::..  ..::                  
XP_016 KNLEMISDEIHERRRSS----AMGPR-GCGVGAEGSSTSVEDLPGSKPEPDAISVASEAF
              100           110        120       130       140     

             330       340       350       360       370       380 
pF1KSD LGPGPAPDTDTLSLLSLRTVASDLQKCDSVEHLRGLSDHVSLDGQELGTRSGGRRGSDGG
                                                                   
XP_016 EDDSCSNFVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVVRPGSLDLPSPVSLSEFGMMF
         150       160       170       180       190       200     

>>NP_001018009 (OMIM: 605612) SH3 domain-binding protein  (298 aa)
 initn: 336 init1: 305 opt: 336  Z-score: 262.3  bits: 57.0 E(85289): 7.2e-08
Smith-Waterman score: 336; 44.7% identity (74.2% similar) in 132 aa overlap (172-303:1-127)

             150       160       170       180       190       200 
pF1KSD SMHNAAREMVFVAEQGVMADKNRLDPTWQEMLNHATCKVNEAEEERLRGEREHQRVTRLC
                                     :::::: .: :::. . :.:  :....   
NP_001                               MLNHATQRVMEAEQTKTRSELVHKETAARY
                                             10        20        30

             210       220       230       240       250       260 
pF1KSD QQAEARVQALQKTLRRAIGKSRPYFELKAQFSQILEEHKAKVTELEQQVAQAKTRYSVAL
       . : .:.. :.: :.:::.::.:::::::..   ::. :  : .:. ... :: .:..::
NP_001 NAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLTLAKGEYKMAL
               40        50        60        70        80        90

             270       280       290       300       310       320 
pF1KSD RNLEQISEQIHARRRGGLPPHPLGPRRSSPVGAEAGPEDMEDGDSGIEGAEGAGLEEGSS
       .:::.::..:: :::..     .::: .  ::::..  ..::                  
NP_001 KNLEMISDEIHERRRSS----AMGPR-GCGVGAEGSSTSVEDLPGSKPEPDAISVASEAF
              100           110        120       130       140     

             330       340       350       360       370       380 
pF1KSD LGPGPAPDTDTLSLLSLRTVASDLQKCDSVEHLRGLSDHVSLDGQELGTRSGGRRGSDGG
                                                                   
NP_001 EDDSCSNFVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVVRPGSLDLPSPVSLSEFGMMF
         150       160       170       180       190       200     

>>XP_016863014 (OMIM: 605612) PREDICTED: SH3 domain-bind  (298 aa)
 initn: 336 init1: 305 opt: 336  Z-score: 262.3  bits: 57.0 E(85289): 7.2e-08
Smith-Waterman score: 336; 44.7% identity (74.2% similar) in 132 aa overlap (172-303:1-127)

             150       160       170       180       190       200 
pF1KSD SMHNAAREMVFVAEQGVMADKNRLDPTWQEMLNHATCKVNEAEEERLRGEREHQRVTRLC
                                     :::::: .: :::. . :.:  :....   
XP_016                               MLNHATQRVMEAEQTKTRSELVHKETAARY
                                             10        20        30

             210       220       230       240       250       260 
pF1KSD QQAEARVQALQKTLRRAIGKSRPYFELKAQFSQILEEHKAKVTELEQQVAQAKTRYSVAL
       . : .:.. :.: :.:::.::.:::::::..   ::. :  : .:. ... :: .:..::
XP_016 NAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLTLAKGEYKMAL
               40        50        60        70        80        90

             270       280       290       300       310       320 
pF1KSD RNLEQISEQIHARRRGGLPPHPLGPRRSSPVGAEAGPEDMEDGDSGIEGAEGAGLEEGSS
       .:::.::..:: :::..     .::: .  ::::..  ..::                  
XP_016 KNLEMISDEIHERRRSS----AMGPR-GCGVGAEGSSTSVEDLPGSKPEPDAISVASEAF
              100           110        120       130       140     

             330       340       350       360       370       380 
pF1KSD LGPGPAPDTDTLSLLSLRTVASDLQKCDSVEHLRGLSDHVSLDGQELGTRSGGRRGSDGG
                                                                   
XP_016 EDDSCSNFVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVVRPGSLDLPSPVSLSEFGMMF
         150       160       170       180       190       200     




393 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 07:03:54 2016 done: Thu Nov  3 07:03:56 2016
 Total Scan time: 10.130 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]
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