Result of FASTA (omim) for pF1KSDA0239
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA0239, 790 aa
  1>>>pF1KSDA0239 790 - 790 aa - 790 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 12.6179+/-0.000402; mu= -12.1334+/- 0.025
 mean_var=444.1440+/-92.716, 0's: 0 Z-trim(123.7): 90  B-trim: 0 in 0/62
 Lambda= 0.060857
 statistics sampled from 43975 (44072) to 43975 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.803), E-opt: 0.2 (0.517), width:  16
 Scan time: 11.410

The best scores are:                                      opt bits E(85289)
NP_056103 (OMIM: 610515) protein Jade-2 isoform 3  ( 790) 5477 495.6 3.5e-139
NP_001276913 (OMIM: 610515) protein Jade-2 isoform ( 791) 5465 494.5 7.2e-139
XP_016864771 (OMIM: 610515) PREDICTED: protein Jad ( 833) 3581 329.1 4.7e-89
XP_005272005 (OMIM: 610515) PREDICTED: protein Jad ( 834) 3581 329.1 4.7e-89
NP_001295072 (OMIM: 610515) protein Jade-2 isoform ( 834) 3581 329.1 4.7e-89
XP_005272003 (OMIM: 610515) PREDICTED: protein Jad ( 834) 3581 329.1 4.7e-89
XP_005272002 (OMIM: 610515) PREDICTED: protein Jad ( 834) 3581 329.1 4.7e-89
XP_011541593 (OMIM: 610515) PREDICTED: protein Jad ( 834) 3581 329.1 4.7e-89
NP_001276914 (OMIM: 610515) protein Jade-2 isoform ( 850) 3581 329.1 4.7e-89
NP_001070913 (OMIM: 300618) protein Jade-3 [Homo s ( 823) 1810 173.6   3e-42
NP_055550 (OMIM: 300618) protein Jade-3 [Homo sapi ( 823) 1810 173.6   3e-42
NP_001274366 (OMIM: 610514) protein Jade-1 isoform ( 830) 1707 164.6 1.6e-39
NP_001274370 (OMIM: 610514) protein Jade-1 isoform ( 509) 1372 135.0 7.8e-31
NP_079176 (OMIM: 610514) protein Jade-1 isoform 2  ( 509) 1372 135.0 7.8e-31
XP_016864116 (OMIM: 610514) PREDICTED: protein Jad ( 529) 1372 135.0   8e-31
XP_016864115 (OMIM: 610514) PREDICTED: protein Jad ( 529) 1372 135.0   8e-31
NP_001274368 (OMIM: 610514) protein Jade-1 isoform ( 842) 1372 135.2 1.1e-30
XP_005263289 (OMIM: 610514) PREDICTED: protein Jad ( 842) 1372 135.2 1.1e-30
NP_001274369 (OMIM: 610514) protein Jade-1 isoform ( 842) 1372 135.2 1.1e-30
NP_001274372 (OMIM: 610514) protein Jade-1 isoform ( 842) 1372 135.2 1.1e-30
NP_955352 (OMIM: 610514) protein Jade-1 isoform 1  ( 842) 1372 135.2 1.1e-30
NP_001274371 (OMIM: 610514) protein Jade-1 isoform ( 842) 1372 135.2 1.1e-30
XP_016884210 (OMIM: 604589) PREDICTED: bromodomain ( 941)  694 75.7   1e-12
XP_016884209 (OMIM: 604589) PREDICTED: bromodomain ( 955)  694 75.7   1e-12
XP_016884208 (OMIM: 604589) PREDICTED: bromodomain ( 958)  694 75.7   1e-12
XP_016884207 (OMIM: 604589) PREDICTED: bromodomain (1023)  694 75.7 1.1e-12
NP_001291738 (OMIM: 604589) bromodomain-containing (1058)  694 75.7 1.1e-12
XP_016884203 (OMIM: 604589) PREDICTED: bromodomain (1187)  694 75.8 1.2e-12
NP_001291737 (OMIM: 604589) bromodomain-containing (1189)  694 75.8 1.2e-12
XP_016884204 (OMIM: 604589) PREDICTED: bromodomain (1189)  694 75.8 1.2e-12
XP_016884206 (OMIM: 604589) PREDICTED: bromodomain (1189)  694 75.8 1.2e-12
XP_016884205 (OMIM: 604589) PREDICTED: bromodomain (1189)  694 75.8 1.2e-12
NP_001305978 (OMIM: 602410) peregrin isoform 3 [Ho (1119)  643 71.3 2.6e-11
XP_005265509 (OMIM: 602410) PREDICTED: peregrin is (1125)  643 71.3 2.6e-11
NP_001305979 (OMIM: 602410) peregrin isoform 4 [Ho (1213)  643 71.3 2.8e-11
NP_004625 (OMIM: 602410) peregrin isoform 2 [Homo  (1214)  643 71.3 2.8e-11
XP_005265507 (OMIM: 602410) PREDICTED: peregrin is (1219)  643 71.3 2.8e-11
NP_001003694 (OMIM: 602410) peregrin isoform 1 [Ho (1220)  643 71.3 2.8e-11
XP_005265506 (OMIM: 602410) PREDICTED: peregrin is (1247)  643 71.3 2.9e-11
XP_011532403 (OMIM: 602410) PREDICTED: peregrin is (1248)  643 71.3 2.9e-11
XP_011532404 (OMIM: 602410) PREDICTED: peregrin is (1248)  643 71.3 2.9e-11
XP_011512794 (OMIM: 616856) PREDICTED: bromodomain ( 832)  623 69.4 7.1e-11
XP_016866231 (OMIM: 616856) PREDICTED: bromodomain (1088)  623 69.5 8.7e-11
XP_011512793 (OMIM: 616856) PREDICTED: bromodomain (1131)  623 69.5 8.9e-11
XP_011512792 (OMIM: 616856) PREDICTED: bromodomain (1144)  623 69.5   9e-11
XP_005249067 (OMIM: 616856) PREDICTED: bromodomain (1205)  623 69.6 9.4e-11
XP_011512791 (OMIM: 616856) PREDICTED: bromodomain (1205)  623 69.6 9.4e-11
NP_056510 (OMIM: 616856) bromodomain and PHD finge (1205)  623 69.6 9.4e-11
XP_005249068 (OMIM: 616856) PREDICTED: bromodomain (1205)  623 69.6 9.4e-11
XP_016880139 (OMIM: 600328) PREDICTED: protein AF- ( 652)  492 57.8 1.7e-07


>>NP_056103 (OMIM: 610515) protein Jade-2 isoform 3 [Hom  (790 aa)
 initn: 5477 init1: 5477 opt: 5477  Z-score: 2619.8  bits: 495.6 E(85289): 3.5e-139
Smith-Waterman score: 5477; 99.9% identity (99.9% similar) in 790 aa overlap (1-790:1-790)

               10        20        30        40        50        60
pF1KSD MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD HIPASRWALSCSLCKECTGTCIQCSMPSCVIAFHVTCAFDHGLEMRTILADNDEVKFKSF
       :::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_056 HIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRGLSTSFPIDGTFFNSWLAQSVQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRGLSTSFPIDGTFFNSWLAQSVQI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD TAENMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TAENMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRL
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD PAKKKPPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PAKKKPPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPA
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD AGDCPILATPESPPPLAPETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AGDCPILATPESPPPLAPETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRL
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD PGARPDAGMGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PGARPDAGMGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAE
              730       740       750       760       770       780

              790
pF1KSD EVVRMGVLAS
       ::::::::::
NP_056 EVVRMGVLAS
              790

>>NP_001276913 (OMIM: 610515) protein Jade-2 isoform 1 [  (791 aa)
 initn: 5463 init1: 3581 opt: 5465  Z-score: 2614.1  bits: 494.5 E(85289): 7.2e-139
Smith-Waterman score: 5465; 99.7% identity (99.7% similar) in 791 aa overlap (1-790:1-791)

               10        20        30        40        50        60
pF1KSD MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD HIPASRWALSCSLCKECTGTCIQCSMPSCVIAFHVTCAFDHGLEMRTILADNDEVKFKSF
       :::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_001 HIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
              430       440       450       460       470       480

              490       500       510        520       530         
pF1KSD NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCR-GLSTSFPIDGTFFNSWLAQSVQ
       ::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::
NP_001 NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRAGLSTSFPIDGTFFNSWLAQSVQ
              490       500       510       520       530       540

     540       550       560       570       580       590         
pF1KSD ITAENMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITAENMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTR
              550       560       570       580       590       600

     600       610       620       630       640       650         
pF1KSD LPAKKKPPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPAKKKPPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSP
              610       620       630       640       650       660

     660       670       680       690       700       710         
pF1KSD AAGDCPILATPESPPPLAPETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAGDCPILATPESPPPLAPETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRR
              670       680       690       700       710       720

     720       730       740       750       760       770         
pF1KSD LPGARPDAGMGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPGARPDAGMGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGA
              730       740       750       760       770       780

     780       790
pF1KSD EEVVRMGVLAS
       :::::::::::
NP_001 EEVVRMGVLAS
              790 

>>XP_016864771 (OMIM: 610515) PREDICTED: protein Jade-2   (833 aa)
 initn: 5463 init1: 3581 opt: 3581  Z-score: 1719.8  bits: 329.1 E(85289): 4.7e-89
Smith-Waterman score: 5317; 94.6% identity (94.6% similar) in 822 aa overlap (1-779:1-822)

               10        20        30        40        50        60
pF1KSD MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD HIPASRWALSCSLCKECTGTCIQCSMPSCVIAFHVTCAFDHGLEMRTILADNDEVKFKSF
       :::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_016 HIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
              430       440       450       460       470       480

              490       500       510                              
pF1KSD NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCR-----------------------
       :::::::::::::::::::::::::::::::::::::                       
XP_016 NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRERSGRRAKGKKSDSKRKGCEGSK
              490       500       510       520       530       540

                           520       530       540       550       
pF1KSD --------------------GLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGHR
                           ::::::::::::::::::::::::::::::::::::::::
XP_016 GSTEKKEKVKAGPDSVLGQLGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGHR
              550       560       570       580       590       600

       560       570       580       590       600       610       
pF1KSD EDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPGS
              610       620       630       640       650       660

       620       630       640       650       660       670       
pF1KSD RTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPLA
              670       680       690       700       710       720

       680       690       700       710       720       730       
pF1KSD PETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVAE
              730       740       750       760       770       780

       740       750       760       770       780       790
pF1KSD RPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS
       ::::::::::::::::::::::::::::::::::::::::::           
XP_016 RPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS
              790       800       810       820       830   

>>XP_005272005 (OMIM: 610515) PREDICTED: protein Jade-2   (834 aa)
 initn: 5463 init1: 3581 opt: 3581  Z-score: 1719.8  bits: 329.1 E(85289): 4.7e-89
Smith-Waterman score: 5310; 94.5% identity (94.5% similar) in 822 aa overlap (1-778:1-822)

               10        20        30        40        50        60
pF1KSD MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD HIPASRWALSCSLCKECTGTCIQCSMPSCVIAFHVTCAFDHGLEMRTILADNDEVKFKSF
       :::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_005 HIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
              430       440       450       460       470       480

              490       500       510                              
pF1KSD NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCR-----------------------
       :::::::::::::::::::::::::::::::::::::                       
XP_005 NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRERSGRRAKGKKSDSKRKGCEGSK
              490       500       510       520       530       540

                            520       530       540       550      
pF1KSD ---------------------GLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGH
                            :::::::::::::::::::::::::::::::::::::::
XP_005 GSTEKKEKVKAGPDSVLGQLAGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGH
              550       560       570       580       590       600

        560       570       580       590       600       610      
pF1KSD REDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPG
              610       620       630       640       650       660

        620       630       640       650       660       670      
pF1KSD SRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPL
              670       680       690       700       710       720

        680       690       700       710       720       730      
pF1KSD APETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVA
              730       740       750       760       770       780

        740       750       760       770       780       790
pF1KSD ERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS
       ::::::::::::::::::::::::::::::::::::::::::            
XP_005 ERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS
              790       800       810       820       830    

>>NP_001295072 (OMIM: 610515) protein Jade-2 isoform 4 [  (834 aa)
 initn: 5463 init1: 3581 opt: 3581  Z-score: 1719.8  bits: 329.1 E(85289): 4.7e-89
Smith-Waterman score: 5310; 94.5% identity (94.5% similar) in 822 aa overlap (1-778:1-822)

               10        20        30        40        50        60
pF1KSD MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD HIPASRWALSCSLCKECTGTCIQCSMPSCVIAFHVTCAFDHGLEMRTILADNDEVKFKSF
       :::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_001 HIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
              430       440       450       460       470       480

              490       500       510                              
pF1KSD NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCR-----------------------
       :::::::::::::::::::::::::::::::::::::                       
NP_001 NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRERSGRRAKGKKSDSKRKGCEGSK
              490       500       510       520       530       540

                            520       530       540       550      
pF1KSD ---------------------GLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGH
                            :::::::::::::::::::::::::::::::::::::::
NP_001 GSTEKKEKVKAGPDSVLGQLAGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGH
              550       560       570       580       590       600

        560       570       580       590       600       610      
pF1KSD REDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPG
              610       620       630       640       650       660

        620       630       640       650       660       670      
pF1KSD SRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPL
              670       680       690       700       710       720

        680       690       700       710       720       730      
pF1KSD APETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVA
              730       740       750       760       770       780

        740       750       760       770       780       790
pF1KSD ERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS
       ::::::::::::::::::::::::::::::::::::::::::            
NP_001 ERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS
              790       800       810       820       830    

>>XP_005272003 (OMIM: 610515) PREDICTED: protein Jade-2   (834 aa)
 initn: 5463 init1: 3581 opt: 3581  Z-score: 1719.8  bits: 329.1 E(85289): 4.7e-89
Smith-Waterman score: 5310; 94.5% identity (94.5% similar) in 822 aa overlap (1-778:1-822)

               10        20        30        40        50        60
pF1KSD MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD HIPASRWALSCSLCKECTGTCIQCSMPSCVIAFHVTCAFDHGLEMRTILADNDEVKFKSF
       :::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_005 HIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
              430       440       450       460       470       480

              490       500       510                              
pF1KSD NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCR-----------------------
       :::::::::::::::::::::::::::::::::::::                       
XP_005 NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRERSGRRAKGKKSDSKRKGCEGSK
              490       500       510       520       530       540

                            520       530       540       550      
pF1KSD ---------------------GLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGH
                            :::::::::::::::::::::::::::::::::::::::
XP_005 GSTEKKEKVKAGPDSVLGQLAGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGH
              550       560       570       580       590       600

        560       570       580       590       600       610      
pF1KSD REDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPG
              610       620       630       640       650       660

        620       630       640       650       660       670      
pF1KSD SRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPL
              670       680       690       700       710       720

        680       690       700       710       720       730      
pF1KSD APETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVA
              730       740       750       760       770       780

        740       750       760       770       780       790
pF1KSD ERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS
       ::::::::::::::::::::::::::::::::::::::::::            
XP_005 ERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS
              790       800       810       820       830    

>>XP_005272002 (OMIM: 610515) PREDICTED: protein Jade-2   (834 aa)
 initn: 5463 init1: 3581 opt: 3581  Z-score: 1719.8  bits: 329.1 E(85289): 4.7e-89
Smith-Waterman score: 5310; 94.5% identity (94.5% similar) in 822 aa overlap (1-778:1-822)

               10        20        30        40        50        60
pF1KSD MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD HIPASRWALSCSLCKECTGTCIQCSMPSCVIAFHVTCAFDHGLEMRTILADNDEVKFKSF
       :::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_005 HIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
              430       440       450       460       470       480

              490       500       510                              
pF1KSD NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCR-----------------------
       :::::::::::::::::::::::::::::::::::::                       
XP_005 NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRERSGRRAKGKKSDSKRKGCEGSK
              490       500       510       520       530       540

                            520       530       540       550      
pF1KSD ---------------------GLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGH
                            :::::::::::::::::::::::::::::::::::::::
XP_005 GSTEKKEKVKAGPDSVLGQLAGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGH
              550       560       570       580       590       600

        560       570       580       590       600       610      
pF1KSD REDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPG
              610       620       630       640       650       660

        620       630       640       650       660       670      
pF1KSD SRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPL
              670       680       690       700       710       720

        680       690       700       710       720       730      
pF1KSD APETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVA
              730       740       750       760       770       780

        740       750       760       770       780       790
pF1KSD ERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS
       ::::::::::::::::::::::::::::::::::::::::::            
XP_005 ERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS
              790       800       810       820       830    

>>XP_011541593 (OMIM: 610515) PREDICTED: protein Jade-2   (834 aa)
 initn: 5463 init1: 3581 opt: 3581  Z-score: 1719.8  bits: 329.1 E(85289): 4.7e-89
Smith-Waterman score: 5310; 94.5% identity (94.5% similar) in 822 aa overlap (1-778:1-822)

               10        20        30        40        50        60
pF1KSD MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD HIPASRWALSCSLCKECTGTCIQCSMPSCVIAFHVTCAFDHGLEMRTILADNDEVKFKSF
       :::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_011 HIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
              430       440       450       460       470       480

              490       500       510                              
pF1KSD NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCR-----------------------
       :::::::::::::::::::::::::::::::::::::                       
XP_011 NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRERSGRRAKGKKSDSKRKGCEGSK
              490       500       510       520       530       540

                            520       530       540       550      
pF1KSD ---------------------GLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGH
                            :::::::::::::::::::::::::::::::::::::::
XP_011 GSTEKKEKVKAGPDSVLGQLAGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGH
              550       560       570       580       590       600

        560       570       580       590       600       610      
pF1KSD REDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPG
              610       620       630       640       650       660

        620       630       640       650       660       670      
pF1KSD SRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPL
              670       680       690       700       710       720

        680       690       700       710       720       730      
pF1KSD APETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVA
              730       740       750       760       770       780

        740       750       760       770       780       790
pF1KSD ERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS
       ::::::::::::::::::::::::::::::::::::::::::            
XP_011 ERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS
              790       800       810       820       830    

>>NP_001276914 (OMIM: 610515) protein Jade-2 isoform 2 [  (850 aa)
 initn: 5463 init1: 3581 opt: 3581  Z-score: 1719.7  bits: 329.1 E(85289): 4.7e-89
Smith-Waterman score: 5310; 94.5% identity (94.5% similar) in 822 aa overlap (1-778:17-838)

                               10        20        30        40    
pF1KSD                 MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQ
                       ::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVPTAAIAVGGYFLGGMEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQ
               10        20        30        40        50        60

           50        60        70        80        90       100    
pF1KSD NEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVR
               70        80        90       100       110       120

          110       120       130       140       150       160    
pF1KSD ILPPLEGPPAQASPSSTMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILPPLEGPPAQASPSSTMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDE
              130       140       150       160       170       180

          170       180       190       200       210       220    
pF1KSD LTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNV
              190       200       210       220       230       240

          230       240       250       260       270       280    
pF1KSD CVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPE
              250       260       270       280       290       300

          290       300       310       320       330       340    
pF1KSD VSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVIAFHVTCAFDHGLE
       :::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
NP_001 VSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLE
              310       320       330       340       350       360

          350       360       370       380       390       400    
pF1KSD MRTILADNDEVKFKSFCQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRTILADNDEVKFKSFCQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDF
              370       380       390       400       410       420

          410       420       430       440       450       460    
pF1KSD YELVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YELVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYR
              430       440       450       460       470       480

          470       480       490       500       510              
pF1KSD RLKLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCR-------
       :::::::::::::::::::::::::::::::::::::::::::::::::::::       
NP_001 RLKLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRERSGRRA
              490       500       510       520       530       540

                                            520       530       540
pF1KSD -------------------------------------GLSTSFPIDGTFFNSWLAQSVQI
                                            :::::::::::::::::::::::
NP_001 KGKKSDSKRKGCEGSKGSTEKKEKVKAGPDSVLGQLAGLSTSFPIDGTFFNSWLAQSVQI
              550       560       570       580       590       600

              550       560       570       580       590       600
pF1KSD TAENMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAENMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRL
              610       620       630       640       650       660

              610       620       630       640       650       660
pF1KSD PAKKKPPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAKKKPPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPA
              670       680       690       700       710       720

              670       680       690       700       710       720
pF1KSD AGDCPILATPESPPPLAPETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGDCPILATPESPPPLAPETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRL
              730       740       750       760       770       780

              730       740       750       760       770       780
pF1KSD PGARPDAGMGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::  
NP_001 PGARPDAGMGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAE
              790       800       810       820       830       840

              790
pF1KSD EVVRMGVLAS
                 
NP_001 EVVRMGVLAS
              850

>>NP_001070913 (OMIM: 300618) protein Jade-3 [Homo sapie  (823 aa)
 initn: 2148 init1: 1273 opt: 1810  Z-score: 879.6  bits: 173.6 E(85289): 3e-42
Smith-Waterman score: 2078; 43.6% identity (67.4% similar) in 803 aa overlap (4-772:2-786)

               10        20        30        40        50        60
pF1KSD MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
          ::..   :::.::  .: .:: ...   ..    ::  : .. :::.:::: :::.:
NP_001   MKRHRPVSSSDSSD--ESPSTSFTSGSMYRI----KSKIPNEH-KKPAEVFRKDLISA
                 10          20            30         40        50 

               70        80        90       100            110     
pF1KSD MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPP-----LEGPPAQ
       ::.:::....::.::..:: :..::::::::::. ...:.: .::.       :   : .
NP_001 MKLPDSHHINPDSYYLFADTWKEEWEKGVQVPASPDTVPQPSLRIIAEKVKDVLFIRPRK
              60        70        80        90       100       110 

             120       130        140       150       160       170
pF1KSD ----ASPSSTMLGEGSQPDWPGG-SRYDLDEIDAYWLELINSELKEMERPELDELTLERV
           .::..:  :  .  .  ..  :::::..: .::. .: .: ::    .::  .:..
NP_001 YIHCSSPDTTEPGYINIMELAASVCRYDLDDMDIFWLQELNEDLAEMGCGPVDENLMEKT
             120       130       140       150       160       170 

              180       190       200       210       220       230
pF1KSD LEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQAC
       .: ::  ::.:: .::::.:::::::::::.:::::::..:.::.:::::::::::::::
NP_001 VEVLERHCHENMNHAIETEEGLGIEYDEDVICDVCRSPDSEEGNDMVFCDKCNVCVHQAC
             180       190       200       210       220       230 

              240       250       260       270       280       290
pF1KSD YGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCP
       ::::::: ::::::.:.::. :.:.::::.::::: :..::::.:::::::::::::.::
NP_001 YGILKVPEGSWLCRSCVLGIYPQCVLCPKKGGALKTTKTGTKWAHVSCALWIPEVSIACP
             240       250       260       270       280       290 

              300       310       320       330       340       350
pF1KSD EKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVIAFHVTCAFDHGLEMRTILA
       :.::::::::::: ::::: :.:::  ::.:::::. ::. ::::::::.:::::.::: 
NP_001 ERMEPITKISHIPPSRWALVCNLCKLKTGACIQCSIKSCITAFHVTCAFEHGLEMKTILD
             300       310       320       330       340       350 

              360           370       380       390       400      
pF1KSD DNDEVKFKSFCQEHSDG----GPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYE
       ..:::::::.: .::..    :  . :  .  : :::    ::..:: :.:..:::.:: 
NP_001 EGDEVKFKSYCLKHSQNRQKLGEAEYPHHRAKEQSQAKS--EKTSLRAQKLRELEEEFYS
             360       370       380       390         400         

        410       420       430       440       450       460      
pF1KSD LVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRL
       ::.  .:: .: .    :::::.:::::::.: :.::. :: :: ..:.: ... .. :.
NP_001 LVRVEDVAAELGMPTLAVDFIYNYWKLKRKSNFNKPLFPPKEDEENGLVQPKEESIHTRM
     410       420       430       440       450       460         

        470       480       490       500       510       520      
pF1KSD KLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRGLSTSFPID
       ..: :::::::::::::::..:::. : .  :.::::: ::..:..:..  ::  .  ..
NP_001 RMFMHLRQDLERVRNLCYMISRREKLKLSHNKIQEQIFGLQVQLLNQEIDAGLPLTNALE
     470       480       490       500       510       520         

        530       540            550        560       570          
pF1KSD GTFFNSWLAQSVQI-----TAENMAMSEWPLNNG-HREDPAPGLLSEELLQ-DEETLL--
       ...:      ....     : :.   :    ..  :  : . .. : . .:  .:.:   
NP_001 NSLFYPPPRITLKLKMPKSTPEDHRNSSTETDQQPHSPDSSSSVHSIRNMQVPQESLEMR
     530       540       550       560       570       580         

         580       590       600       610       620        630    
pF1KSD --SFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPGSRTTPDKA-PKKTWGQDAG
         :. : :    ..    . ...:  ::..    :    :.:.    ..  :    : : 
NP_001 TKSYPRYPLESKNNRLLASLSHSRSEAKESS---PAWRTPSSECYHGQSLGKPLVLQAAL
     590       600       610       620          630       640      

          640       650         660       670       680       690  
pF1KSD SGKGGQGPPTRKPPRR--TSSHLPSSPAAGDCPILATPESPPPLAPETPDEAASVAADSD
        :... :    .:  .   :. : .:  .:.  .     :   .  . :  .  ......
NP_001 HGQSSIGNGKSQPNSKFAKSNGLEGS-WSGN--VTQKDSSSEMFCDQEPVFSPHLVSQGS
        650       660       670          680       690       700   

            700       710       720        730            740      
pF1KSD VQVPGPAASPKPLGRLRPPRESKVTRRLPG-ARPDAGMGPPSA-----VAERPKVSLHFD
        .        . . .    :  : :. :   ..:  .:.:        : .:      ..
NP_001 FRKSTVEHFSRSF-KETTNRWVKNTEDLQCYVKPTKNMSPKEQFWGRQVLRRSAGRAPYQ
           710        720       730       740       750       760  

        750       760       770       780       790                
pF1KSD TETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS                
        :.:::  : :.:::..:. ::. ..                                  
NP_001 -ENDGYCPDLELSDSEAES-DGNKEKVRVRKDSSDRENPPHDSRRDCHGKSKTHPLSHSS
             770       780        790       800       810       820




790 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 00:52:55 2016 done: Thu Nov  3 00:52:57 2016
 Total Scan time: 11.410 Total Display time:  0.200

Function used was FASTA [36.3.4 Apr, 2011]
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