Result of FASTA (omim) for pF1KA0151
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA0151, 716 aa
  1>>>pF1KA0151 716 - 716 aa - 716 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.3464+/-0.000624; mu= 3.1930+/- 0.038
 mean_var=761.8380+/-174.276, 0's: 0 Z-trim(115.4): 706  B-trim: 0 in 0/56
 Lambda= 0.046467
 statistics sampled from 25025 (25871) to 25025 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.303), width:  16
 Scan time: 10.390

The best scores are:                                      opt bits E(85289)
XP_005273413 (OMIM: 605048) PREDICTED: inhibitor o ( 716) 4690 331.6 6.6e-90
NP_054721 (OMIM: 605048) inhibitor of nuclear fact ( 716) 4690 331.6 6.6e-90
NP_001180251 (OMIM: 605048) inhibitor of nuclear f ( 657) 4207 299.1 3.6e-80
NP_001180250 (OMIM: 605048) inhibitor of nuclear f ( 631) 4154 295.6 4.1e-79
XP_016858357 (OMIM: 605048) PREDICTED: inhibitor o ( 594) 3911 279.2 3.2e-74
XP_005268867 (OMIM: 604834,616439) PREDICTED: seri ( 729) 1981 150.0 3.1e-35
XP_005268866 (OMIM: 604834,616439) PREDICTED: seri ( 729) 1981 150.0 3.1e-35
NP_037386 (OMIM: 604834,616439) serine/threonine-p ( 729) 1981 150.0 3.1e-35
XP_016871101 (OMIM: 600664,613630) PREDICTED: inhi ( 598)  388 43.1   0.004
NP_001307857 (OMIM: 600664,613630) inhibitor of nu ( 719)  388 43.2  0.0043
NP_001269 (OMIM: 600664,613630) inhibitor of nucle ( 745)  388 43.2  0.0044
XP_016871100 (OMIM: 600664,613630) PREDICTED: inhi ( 814)  388 43.3  0.0046
XP_011537101 (OMIM: 603168) PREDICTED: serine/thre (1044)  375 42.6  0.0093
NP_003556 (OMIM: 603168) serine/threonine-protein  (1050)  375 42.6  0.0094
XP_011537100 (OMIM: 603168) PREDICTED: serine/thre (1073)  375 42.7  0.0094
NP_001136082 (OMIM: 608650) serine/threonine-prote (1036)  374 42.6  0.0097
NP_055498 (OMIM: 608650) serine/threonine-protein  (1036)  374 42.6  0.0097


>>XP_005273413 (OMIM: 605048) PREDICTED: inhibitor of nu  (716 aa)
 initn: 4690 init1: 4690 opt: 4690  Z-score: 1735.1  bits: 331.6 E(85289): 6.6e-90
Smith-Waterman score: 4690; 100.0% identity (100.0% similar) in 716 aa overlap (1-716:1-716)

               10        20        30        40        50        60
pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG
              610       620       630       640       650       660

              670       680       690       700       710      
pF1KA0 AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV
              670       680       690       700       710      

>>NP_054721 (OMIM: 605048) inhibitor of nuclear factor k  (716 aa)
 initn: 4690 init1: 4690 opt: 4690  Z-score: 1735.1  bits: 331.6 E(85289): 6.6e-90
Smith-Waterman score: 4690; 100.0% identity (100.0% similar) in 716 aa overlap (1-716:1-716)

               10        20        30        40        50        60
pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG
              610       620       630       640       650       660

              670       680       690       700       710      
pF1KA0 AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV
              670       680       690       700       710      

>>NP_001180251 (OMIM: 605048) inhibitor of nuclear facto  (657 aa)
 initn: 4207 init1: 4207 opt: 4207  Z-score: 1560.4  bits: 299.1 E(85289): 3.6e-80
Smith-Waterman score: 4207; 100.0% identity (100.0% similar) in 644 aa overlap (1-644:1-644)

               10        20        30        40        50        60
pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG
       ::::::::::::::::::::::::::::::::::::::::::::                
NP_001 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKHARALRGDEAAGI   
              610       620       630       640       650          

              670       680       690       700       710      
pF1KA0 AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV

>>NP_001180250 (OMIM: 605048) inhibitor of nuclear facto  (631 aa)
 initn: 4154 init1: 4154 opt: 4154  Z-score: 1541.3  bits: 295.6 E(85289): 4.1e-79
Smith-Waterman score: 4154; 100.0% identity (100.0% similar) in 631 aa overlap (86-716:1-631)

          60        70        80        90       100       110     
pF1KA0 FEVLRKLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVV
                                     ::::::::::::::::::::::::::::::
NP_001                               MEYCSSGSLLSVLESPENAFGLPEDEFLVV
                                             10        20        30

         120       130       140       150       160       170     
pF1KA0 LRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYG
               40        50        60        70        80        90

         180       190       200       210       220       230     
pF1KA0 TEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMY
              100       110       120       130       140       150

         240       250       260       270       280       290     
pF1KA0 RITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGF
              160       170       180       190       200       210

         300       310       320       330       340       350     
pF1KA0 DQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFE
              220       230       240       250       260       270

         360       370       380       390       400       410     
pF1KA0 GHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTA
              280       290       300       310       320       330

         420       430       440       450       460       470     
pF1KA0 KGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTE
              340       350       360       370       380       390

         480       490       500       510       520       530     
pF1KA0 RFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVH
              400       410       420       430       440       450

         540       550       560       570       580       590     
pF1KA0 EDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEE
              460       470       480       490       500       510

         600       610       620       630       640       650     
pF1KA0 CVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQ
              520       530       540       550       560       570

         660       670       680       690       700       710     
pF1KA0 DRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPD
              580       590       600       610       620       630

        
pF1KA0 V
       :
NP_001 V
        

>>XP_016858357 (OMIM: 605048) PREDICTED: inhibitor of nu  (594 aa)
 initn: 3911 init1: 3911 opt: 3911  Z-score: 1453.5  bits: 279.2 E(85289): 3.2e-74
Smith-Waterman score: 3911; 100.0% identity (100.0% similar) in 594 aa overlap (123-716:1-594)

            100       110       120       130       140       150  
pF1KA0 SLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSI
                                     ::::::::::::::::::::::::::::::
XP_016                               MNHLRENGIVHRDIKPGNIMRLVGEEGQSI
                                             10        20        30

            160       170       180       190       200       210  
pF1KA0 YKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLY
               40        50        60        70        80        90

            220       230       240       250       260       270  
pF1KA0 HAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLG
              100       110       120       130       140       150

            280       290       300       310       320       330  
pF1KA0 LQSQLVPILANILEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQSQLVPILANILEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTI
              160       170       180       190       200       210

            340       350       360       370       380       390  
pF1KA0 AIFQEAVHKQTSVAPRHQEYLFEGHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIFQEAVHKQTSVAPRHQEYLFEGHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAF
              220       230       240       250       260       270

            400       410       420       430       440       450  
pF1KA0 RDPALDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDPALDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQA
              280       290       300       310       320       330

            460       470       480       490       500       510  
pF1KA0 TCRRTLEVARTSLLYLSSSLGTERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TCRRTLEVARTSLLYLSSSLGTERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQN
              340       350       360       370       380       390

            520       530       540       550       560       570  
pF1KA0 ITETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQ
              400       410       420       430       440       450

            580       590       600       610       620       630  
pF1KA0 IHKLDKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IHKLDKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACN
              460       470       480       490       500       510

            640       650       660       670       680       690  
pF1KA0 TEAQGVQESLSKLLEELSHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEAQGVQESLSKLLEELSHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKL
              520       530       540       550       560       570

            700       710      
pF1KA0 LASDLLDNNRIIERLNRVPAPPDV
       ::::::::::::::::::::::::
XP_016 LASDLLDNNRIIERLNRVPAPPDV
              580       590    

>>XP_005268867 (OMIM: 604834,616439) PREDICTED: serine/t  (729 aa)
 initn: 2148 init1: 1951 opt: 1981  Z-score: 753.5  bits: 150.0 E(85289): 3.1e-35
Smith-Waterman score: 2222; 49.3% identity (74.9% similar) in 718 aa overlap (1-707:1-714)

               10        20        30        40        50        60
pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
       ::::.:.::  .:.:::::::.:...:.::.:.: :.::::. :.::: .::.::::::.
XP_005 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
       ::::.:::::::.::   .:.:::.::.:  ::: .::: : ::.::::.:::.::: ::
XP_005 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
       .::::::::::::::::::::::..::.:::.::::::::::::.:::.:::.:::::::
XP_005 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
       :::::::::::: .:: .:.::::::::::.:::::::::: :: :::::::.::.: : 
XP_005 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
       ::.:::.:.:. ::::..::  .:..:.:: :::  :.:.::::::..: ::::::::::
XP_005 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
       ::::::.:.:.:::::.: . :.::::..:: .::.: :.:::..   .:: ..::.  :
XP_005 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
       :::.  :::. .::  .:. . :    . ...    ...::  :. ::..: . ::.. :
XP_005 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
              370       380       390       400       410       420

              430       440       450           460       470      
pF1KA0 AGYQALRLARALLDGQELMFRGLHWVMEVLQ----ATCRRTLEVARTSLLYLSSSLGT--
       .   : :.: .::  :::: .:..:..:...     : ..  ::. :  . . .   :  
XP_005 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
              430       440       450       460       470       480

            480       490       500       510       520            
pF1KA0 --ERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLS---SLNRELVK
         :.. ..  . :  ::   ......:  :.   .    .. . .  ::   ::    ..
XP_005 VYEKLMKI--NLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAH
                490       500       510       520       530        

     530       540       550       560       570       580         
pF1KA0 SRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLL
       ..    .::.....:  :. :. :: ::::.. .  :.::::::::.:: .. . : . .
XP_005 QEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAM
      540       550       560       570       580       590        

     590       600       610       620       630       640         
pF1KA0 QVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEEL
         : .:::.::.: :    . .: . . :..:  .  .    . :..  ::  ..: : :
XP_005 THFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETL
      600       610       620       630       640       650        

     650       660       670       680       690       700         
pF1KA0 SHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNR
        ....   ..: . .  :: :  : :  .. : :..: : :. ....: .::.:.::.  
XP_005 PQKMFTA-SSGIKHTMTPIYP-SSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGS
      660        670        680       690       700       710      

     710            
pF1KA0 VPAPPDV      
                    
XP_005 LTMDGGLRNVDCL
        720         

>>XP_005268866 (OMIM: 604834,616439) PREDICTED: serine/t  (729 aa)
 initn: 2148 init1: 1951 opt: 1981  Z-score: 753.5  bits: 150.0 E(85289): 3.1e-35
Smith-Waterman score: 2222; 49.3% identity (74.9% similar) in 718 aa overlap (1-707:1-714)

               10        20        30        40        50        60
pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
       ::::.:.::  .:.:::::::.:...:.::.:.: :.::::. :.::: .::.::::::.
XP_005 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
       ::::.:::::::.::   .:.:::.::.:  ::: .::: : ::.::::.:::.::: ::
XP_005 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
       .::::::::::::::::::::::..::.:::.::::::::::::.:::.:::.:::::::
XP_005 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
       :::::::::::: .:: .:.::::::::::.:::::::::: :: :::::::.::.: : 
XP_005 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
       ::.:::.:.:. ::::..::  .:..:.:: :::  :.:.::::::..: ::::::::::
XP_005 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
       ::::::.:.:.:::::.: . :.::::..:: .::.: :.:::..   .:: ..::.  :
XP_005 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
       :::.  :::. .::  .:. . :    . ...    ...::  :. ::..: . ::.. :
XP_005 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
              370       380       390       400       410       420

              430       440       450           460       470      
pF1KA0 AGYQALRLARALLDGQELMFRGLHWVMEVLQ----ATCRRTLEVARTSLLYLSSSLGT--
       .   : :.: .::  :::: .:..:..:...     : ..  ::. :  . . .   :  
XP_005 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
              430       440       450       460       470       480

            480       490       500       510       520            
pF1KA0 --ERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLS---SLNRELVK
         :.. ..  . :  ::   ......:  :.   .    .. . .  ::   ::    ..
XP_005 VYEKLMKI--NLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAH
                490       500       510       520       530        

     530       540       550       560       570       580         
pF1KA0 SRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLL
       ..    .::.....:  :. :. :: ::::.. .  :.::::::::.:: .. . : . .
XP_005 QEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAM
      540       550       560       570       580       590        

     590       600       610       620       630       640         
pF1KA0 QVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEEL
         : .:::.::.: :    . .: . . :..:  .  .    . :..  ::  ..: : :
XP_005 THFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETL
      600       610       620       630       640       650        

     650       660       670       680       690       700         
pF1KA0 SHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNR
        ....   ..: . .  :: :  : :  .. : :..: : :. ....: .::.:.::.  
XP_005 PQKMFTA-SSGIKHTMTPIYP-SSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGS
      660        670        680       690       700       710      

     710            
pF1KA0 VPAPPDV      
                    
XP_005 LTMDGGLRNVDCL
        720         

>>NP_037386 (OMIM: 604834,616439) serine/threonine-prote  (729 aa)
 initn: 2148 init1: 1951 opt: 1981  Z-score: 753.5  bits: 150.0 E(85289): 3.1e-35
Smith-Waterman score: 2222; 49.3% identity (74.9% similar) in 718 aa overlap (1-707:1-714)

               10        20        30        40        50        60
pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
       ::::.:.::  .:.:::::::.:...:.::.:.: :.::::. :.::: .::.::::::.
NP_037 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
       ::::.:::::::.::   .:.:::.::.:  ::: .::: : ::.::::.:::.::: ::
NP_037 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
       .::::::::::::::::::::::..::.:::.::::::::::::.:::.:::.:::::::
NP_037 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
       :::::::::::: .:: .:.::::::::::.:::::::::: :: :::::::.::.: : 
NP_037 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
       ::.:::.:.:. ::::..::  .:..:.:: :::  :.:.::::::..: ::::::::::
NP_037 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
       ::::::.:.:.:::::.: . :.::::..:: .::.: :.:::..   .:: ..::.  :
NP_037 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
       :::.  :::. .::  .:. . :    . ...    ...::  :. ::..: . ::.. :
NP_037 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
              370       380       390       400       410       420

              430       440       450           460       470      
pF1KA0 AGYQALRLARALLDGQELMFRGLHWVMEVLQ----ATCRRTLEVARTSLLYLSSSLGT--
       .   : :.: .::  :::: .:..:..:...     : ..  ::. :  . . .   :  
NP_037 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
              430       440       450       460       470       480

            480       490       500       510       520            
pF1KA0 --ERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLS---SLNRELVK
         :.. ..  . :  ::   ......:  :.   .    .. . .  ::   ::    ..
NP_037 VYEKLMKI--NLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAH
                490       500       510       520       530        

     530       540       550       560       570       580         
pF1KA0 SRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLL
       ..    .::.....:  :. :. :: ::::.. .  :.::::::::.:: .. . : . .
NP_037 QEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAM
      540       550       560       570       580       590        

     590       600       610       620       630       640         
pF1KA0 QVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEEL
         : .:::.::.: :    . .: . . :..:  .  .    . :..  ::  ..: : :
NP_037 THFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETL
      600       610       620       630       640       650        

     650       660       670       680       690       700         
pF1KA0 SHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNR
        ....   ..: . .  :: :  : :  .. : :..: : :. ....: .::.:.::.  
NP_037 PQKMFTA-SSGIKHTMTPIYP-SSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGS
      660        670        680       690       700       710      

     710            
pF1KA0 VPAPPDV      
                    
NP_037 LTMDGGLRNVDCL
        720         

>>XP_016871101 (OMIM: 600664,613630) PREDICTED: inhibito  (598 aa)
 initn: 313 init1: 195 opt: 388  Z-score: 177.1  bits: 43.1 E(85289): 0.004
Smith-Waterman score: 474; 25.7% identity (53.3% similar) in 604 aa overlap (9-572:15-585)

                     10        20        30        40        50    
pF1KA0       MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVR
                     :.  . :: :. ..:   ....    .:.:        . ::   .
XP_016 MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
               10        20        30        40        50        60

           60        70         80          90       100       110 
pF1KA0 EFEVLRKLNHQNIVKLFAV-EETGGSRQKV--LVMEYCSSGSLLSVLESPENAFGLPEDE
       :.....:::: :.::   : :: .   . :  :.:::::.:.: ..:..:::  :: :..
XP_016 EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
               70        80        90       100       110       120

             120       130       140        150       160       170
pF1KA0 FLVVLRCVVAGMNHLRENGIVHRDIKPGNI-MRLVGEEGQSIYKLTDFGAARELDDDEKF
       .: .:  . .:. .:.:: :.:::.:: :: .. ::  :. :.:. :.: :...:.    
XP_016 ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVG--GKIIHKIIDLGYAKDVDQGSLC
              130       140       150         160       170        

              180       190       200       210       220       230
pF1KA0 VSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRN
       .:  :: .:: :...:     ::    . .::: ::.:. ...  .:  ::.    :   
XP_016 TSFVGTLQYLAPELFEN----KP----YTATVDYWSFGTMVFECIAGYRPFLHHLQPFTW
      180       190               200       210       220       230

              240       250       260          270       280       
pF1KA0 KEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPIT---CQLSLGLQSQLVPILANI---
       .:   .:  . :   .:  .   .: ...:  ::     :.: .  . . . .. :    
XP_016 HE---KIKKKDPKCIFACEEM--SGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQ
                 240         250       260       270       280     

                 290       300       310       320       330       
pF1KA0 -------LEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQE
              : ..: .:      :.  . ::.  .::......: .  . .   ...  .: 
XP_016 QRGGPVDLTLKQPRC------FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQS
         290       300             310       320       330         

       340       350       360       370           380          390
pF1KA0 AVHKQTSVAPRHQEYLFEGHLCVLEPSVSAQHIA----HTTASSPLTLF--STAIPKG-L
        ....:..    :: : :  .  :.:   :.. .    .   :  . ::  : .. .: .
XP_016 RIERETGINTGSQELLSETGIS-LDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPF
     340       350       360        370       380       390        

              400       410       420       430       440       450
pF1KA0 AFRDPALDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEVL
       : :. .  :  .:    .:      . : .   .:.. . .: .    .:.: . .:  :
XP_016 ASRSLSDCVNYIVQDSKIQLPIIQLRKVWA---EAVHYVSGLKEDYSRLFQGQRAAMLSL
      400       410       420          430       440       450     

                    460             470         480       490      
pF1KA0 Q------ATCRRTLEVARTSL------LYLSSSLGTERFSS--VAGTPEIQELKAAAELR
              .  . ::  :  .:      .. : .:  ::.:   . :    . :::  :..
XP_016 LRYNANLTKMKNTLISASQQLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEME
         460       470       480       490       500       510     

        500       510       520       530       540       550      
pF1KA0 SRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQ
        .    :::       :   .... ::. :... . . .  :. . ..   ..   .:::
XP_016 EKAIHYAEV-----GVIGYLEDQIMSLHAEIMELQKSPYGRRQGDLMESLEQRAIDLYKQ
         520            530       540       550       560       570

        560         570       580       590       600       610    
pF1KA0 FKKSRMRPGLGY--NEEQIHKLDKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVV
       .:.   ::.. .  : ::                                          
XP_016 LKH---RPSVEHLLNTEQGLLERVLDGESEA                             
                 580       590                                     

>>NP_001307857 (OMIM: 600664,613630) inhibitor of nuclea  (719 aa)
 initn: 313 init1: 195 opt: 388  Z-score: 176.4  bits: 43.2 E(85289): 0.0043
Smith-Waterman score: 469; 25.6% identity (53.2% similar) in 594 aa overlap (9-564:15-575)

                     10        20        30        40        50    
pF1KA0       MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVR
                     :.  . :: :. ..:   ....    .:.:        . ::   .
NP_001 MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
               10        20        30        40        50        60

           60        70         80          90       100       110 
pF1KA0 EFEVLRKLNHQNIVKLFAV-EETGGSRQKV--LVMEYCSSGSLLSVLESPENAFGLPEDE
       :.....:::: :.::   : :: .   . :  :.:::::.:.: ..:..:::  :: :..
NP_001 EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
               70        80        90       100       110       120

             120       130       140        150       160       170
pF1KA0 FLVVLRCVVAGMNHLRENGIVHRDIKPGNI-MRLVGEEGQSIYKLTDFGAARELDDDEKF
       .: .:  . .:. .:.:: :.:::.:: :: .. ::  :. :.:. :.: :...:.    
NP_001 ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVG--GKIIHKIIDLGYAKDVDQGSLC
              130       140       150         160       170        

              180       190       200       210       220       230
pF1KA0 VSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRN
       .:  :: .:: :...:     ::    . .::: ::.:. ...  .:  ::.    :   
NP_001 TSFVGTLQYLAPELFE----NKP----YTATVDYWSFGTMVFECIAGYRPFLHHLQPFTW
      180       190               200       210       220       230

              240       250       260          270       280       
pF1KA0 KEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPIT---CQLSLGLQSQLVPILANI---
       .:   .:  . :   .:  .   .: ...:  ::     :.: .  . . . .. :    
NP_001 HE---KIKKKDPKCIFACEEM--SGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQ
                 240         250       260       270       280     

                 290       300       310       320       330       
pF1KA0 -------LEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQE
              : ..: .:      :.  . ::.  .::......: .  . .   ...  .: 
NP_001 QRGGPVDLTLKQPRC------FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQS
         290       300             310       320       330         

       340       350       360       370           380          390
pF1KA0 AVHKQTSVAPRHQEYLFEGHLCVLEPSVSAQHIA----HTTASSPLTLF--STAIPKG-L
        ....:..    :: : :  .  :.:   :.. .    .   :  . ::  : .. .: .
NP_001 RIERETGINTGSQELLSETGIS-LDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPF
     340       350       360        370       380       390        

              400       410       420       430       440       450
pF1KA0 AFRDPALDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEVL
       : :. .  :  .:    .:      . : .   .:.. . .: .    .:.: . .:  :
NP_001 ASRSLSDCVNYIVQDSKIQLPIIQLRKVWA---EAVHYVSGLKEDYSRLFQGQRAAMLSL
      400       410       420          430       440       450     

                    460             470         480       490      
pF1KA0 Q------ATCRRTLEVARTSL------LYLSSSLGTERFSS--VAGTPEIQELKAAAELR
              .  . ::  :  .:      .. : .:  ::.:   . :    . :::  :..
NP_001 LRYNANLTKMKNTLISASQQLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEME
         460       470       480       490       500       510     

        500       510       520       530       540       550      
pF1KA0 SRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQ
        .    :::       :   .... ::. :... . . .  :. . ..   ..   .:::
NP_001 EKAIHYAEV-----GVIGYLEDQIMSLHAEIMELQKSPYGRRQGDLMESLEQRAIDLYKQ
         520            530       540       550       560       570

        560       570       580       590       600       610      
pF1KA0 FKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHE
       .:.   ::                                                    
NP_001 LKH---RPSDHSYSDSTEMVKIIVHTVQSQDRVLKELFGHLSKLLGCKQKIIDLLPKVEV
                 580       590       600       610       620       




716 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 18:16:26 2016 done: Wed Nov  2 18:16:28 2016
 Total Scan time: 10.390 Total Display time:  0.170

Function used was FASTA [36.3.4 Apr, 2011]
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