Result of FASTA (omim) for pF1KB9867
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB9867, 446 aa
  1>>>pF1KB9867 446 - 446 aa - 446 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.8135+/-0.000518; mu= 20.6742+/- 0.032
 mean_var=96.4953+/-22.864, 0's: 0 Z-trim(109.6): 554  B-trim: 1891 in 2/48
 Lambda= 0.130563
 statistics sampled from 17053 (17807) to 17053 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.568), E-opt: 0.2 (0.209), width:  16
 Scan time:  6.670

The best scores are:                                      opt bits E(85289)
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 2952 567.3 2.8e-161
NP_000789 (OMIM: 126453,143465,606798) D(1B) dopam ( 477) 1045 208.1   4e-53
NP_000016 (OMIM: 109691,601665) beta-3 adrenergic  ( 408)  677 138.7 2.7e-32
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429)  651 133.9 8.2e-31
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429)  651 133.9 8.2e-31
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455)  651 133.9 8.5e-31
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466)  651 133.9 8.6e-31
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475)  651 133.9 8.7e-31
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475)  651 133.9 8.7e-31
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475)  651 133.9 8.7e-31
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475)  651 133.9 8.7e-31
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572)  640 132.0 4.1e-30
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520)  636 131.2 6.5e-30
NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432)  597 123.7 9.5e-28
NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445)  597 123.7 9.7e-28
NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479)  597 123.8   1e-27
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413)  587 121.8 3.4e-27
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic  ( 477)  570 118.7 3.4e-26
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342)  567 117.9 4.1e-26
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308)  555 115.6 1.8e-25
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370)  555 115.7 2.1e-25
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317)  554 115.4 2.1e-25
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324)  554 115.5 2.2e-25
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372)  554 115.5 2.4e-25
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366)  537 112.3 2.2e-24
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328)  533 111.5 3.4e-24
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331)  533 111.5 3.4e-24
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389)  533 111.6 3.8e-24
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402)  533 111.6 3.9e-24
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556)  533 111.8 4.7e-24
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359)  522 109.5 1.5e-23
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362)  522 109.5 1.5e-23
NP_001124527 (OMIM: 142703) histamine H2 receptor  ( 397)  522 109.5 1.6e-23
XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422)  522 109.6 1.7e-23
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422)  522 109.6 1.7e-23
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422)  522 109.6 1.7e-23
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422)  522 109.6 1.7e-23
XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422)  522 109.6 1.7e-23
NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360)  520 109.1   2e-23
NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378)  520 109.1   2e-23
NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387)  520 109.1 2.1e-23
NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388)  520 109.1 2.1e-23
NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411)  520 109.2 2.1e-23
NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428)  520 109.2 2.2e-23
NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471)  507 106.8 1.3e-22
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465)  491 103.8   1e-21
NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440)  471 100.0 1.3e-20
NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458)  467 99.2 2.3e-20
NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458)  467 99.2 2.3e-20
NP_001517 (OMIM: 602393) orexin receptor type 2 [H ( 444)  450 96.0 2.1e-19


>>NP_000785 (OMIM: 126449) D(1A) dopamine receptor [Homo  (446 aa)
 initn: 2952 init1: 2952 opt: 2952  Z-score: 3016.4  bits: 567.3 E(85289): 2.8e-161
Smith-Waterman score: 2952; 100.0% identity (100.0% similar) in 446 aa overlap (1-446:1-446)

               10        20        30        40        50        60
pF1KB9 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB9 GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB9 VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
              370       380       390       400       410       420

              430       440      
pF1KB9 SVILDYDTDVSLEKIQPITQNGQHPT
       ::::::::::::::::::::::::::
NP_000 SVILDYDTDVSLEKIQPITQNGQHPT
              430       440      

>>NP_000789 (OMIM: 126453,143465,606798) D(1B) dopamine   (477 aa)
 initn: 1627 init1: 784 opt: 1045  Z-score: 1074.8  bits: 208.1 E(85289): 4e-53
Smith-Waterman score: 1647; 58.2% identity (79.1% similar) in 450 aa overlap (23-444:40-477)

                       10        20        30        40        50  
pF1KB9         MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFR
                                     ...:::.:.:::. :::::.:::::..: :
NP_000 AYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSR
      10        20        30        40        50        60         

             60        70        80        90       100       110  
pF1KB9 HLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASIL
       :::...:: :..:::::::.::.::::::::::.::.::::.::..::::::::::::::
NP_000 HLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASIL
      70        80        90       100       110       120         

            120       130       140       150       160       170  
pF1KB9 NLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTS--
       :::::::::::::: ::::.:::: . :......:::::.:::::::::.::. . .:  
NP_000 NLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWG
     130       140       150       160       170       180         

                   180              190       200       210        
pF1KB9 ----PSD-GNATSLAETI-------DNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIY
           :.. .: :   : .       .::::::.::::::::.::::::::::::::::::
NP_000 GLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIY
     190       200       210       220       230       240         

      220       230       240       250       260       270        
pF1KB9 RIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIM
       :::: :::::..::::: ::..:.....      :. :..:.. :.:.::::::::::::
NP_000 RIAQVQIRRISSLERAAEHAQSCRSSAA------CA-PDTSLRASIKKETKVLKTLSVIM
     250       260       270              280       290       300  

      280       290        300          310       320       330    
pF1KB9 GVFVCCWLPFFILNCILPFC-GSGETQP--F-CIDSNTFDVFVWFGWANSSLNPIIYAFN
       :::::::::::::::..::: :  :  :  : :.. .:::::::::::::::::.:::::
NP_000 GVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFN
            310       320       330       340       350       360  

          340       350       360       370       380       390    
pF1KB9 ADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHA
       :::.:.:. :::: ..:  :   .:::.:.:.   ..: ...           ....:.:
NP_000 ADFQKVFAQLLGCSHFCSRT--PVETVNISNE---LISYNQDIVFHKEIAAAYIHMMPNA
            370       380         390          400       410       

            400       410              420        430       440    
pF1KB9 V--GSSEDLKKEEAAGIARPLE--KLSP-----ALSVI-LDYDTDVSLEKIQPITQNGQH
       :  :. :  . :: . . : ..  . ::     : ::  :: . ..::.:: :.: :: :
NP_000 VTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
       420       430       440       450       460       470       

         
pF1KB9 PT

>>NP_000016 (OMIM: 109691,601665) beta-3 adrenergic rece  (408 aa)
 initn: 476 init1: 164 opt: 677  Z-score: 700.9  bits: 138.7 E(85289): 2.7e-32
Smith-Waterman score: 677; 33.2% identity (62.9% similar) in 367 aa overlap (25-378:39-395)

                     10        20        30        40        50    
pF1KB9       MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHL
                                     :.. .:.: .:.:. :: :: .:.    .:
NP_000 SSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRL
       10        20        30        40        50        60        

           60        70        80        90        100       110   
pF1KB9 RSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSF-CNIWVAFDIMCSTASILN
       .. .:: :: :::..::....::.:  :.  ..: ::.:.  :..:.. :..: :::: .
NP_000 QT-MTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIET
       70         80        90       100       110       120       

           120       130       140       150       160       170   
pF1KB9 LCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSD
       ::...:::: :...:.::   .: . :   . ..:..:. .:: :.. .: ..     .:
NP_000 LCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVG----AD
       130       140       150       160       170       180       

           180       190       200       210       220        230  
pF1KB9 GNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRI-AALE
       ..:     .   :  . .  :.. :: .:::.:. .:. .:.:.. .: .:.: . . : 
NP_000 AEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELG
           190       200       210       220       230       240   

             240       250               260       270       280   
pF1KB9 R-AAVHAKNCQTTTGNGKPV-ECSQPES-------SFKMSFKRETKVLKTLSVIMGVFVC
       :    ..    . .    ::  :. ::.         ..   :: ..: ::..:::.:. 
NP_000 RFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTL
           250       260       270       280       290       300   

           290       300       310       320       330       340   
pF1KB9 CWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFST
       ::::::. : .  . :     :  . . .: .. :.:.:::..::.::  . :::.::  
NP_000 CWLPFFLANVLRALGG-----PSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRR
           310            320       330       340       350        

            350       360        370       380       390       400 
pF1KB9 LLG-CYRLCPATNNAIETVSINNNGA-AMFSSHHEPRGSISKECNLVYLIPHAVGSSEDL
       ::  : :  :    :    ..  .:. :  ::  .::                       
NP_000 LLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS          
      360       370       380       390       400                  

             410       420       430       440      
pF1KB9 KKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT

>>XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A adrene  (429 aa)
 initn: 574 init1: 276 opt: 651  Z-score: 674.2  bits: 133.9 E(85289): 8.2e-31
Smith-Waterman score: 717; 36.9% identity (66.3% similar) in 347 aa overlap (19-351:22-347)

                  10        20        30        40        50       
pF1KB9    MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSK
                            ..:  :: . .:. :::  .::: ::  .:   :::.: 
XP_006 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-
               10        20        30        40        50          

        60        70        80        90        100       110      
pF1KB9 VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCV
       ::......:::.:::..  :.:..:. :. :.: ::  :::::.: :..: ::::..::.
XP_006 VTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
      60        70        80        90       100       110         

        120       130       140       150       160       170      
pF1KB9 ISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNA
       ::.::: ..: :.::   .: . ... .  .:.::..::. :. ..:..  : .: :   
XP_006 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ--P-APED---
     120       130       140       150       160           170     

        180       190       200       210       220       230      
pF1KB9 TSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAA-
           :::  :. .    :.. :.. :::.:.::..: : :.: .:... : . .  ..  
XP_006 ----ETI--CQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDK
                  180       190       200       210       220      

                  240       250       260        270       280     
pF1KB9 ---------VHAKNCQTTTGNGKPVECSQPESSFKM-SFKRETKVLKTLSVIMGVFVCCW
                .: ::  .  :.:     .. . : .. .:.:: :. :::....: :: ::
XP_006 SDSEQVTLRIHRKNAPAG-GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
        230       240        250       260       270       280     

         290       300        310       320       330        340   
pF1KB9 LPFFILNCILPFCGSGETQP-FCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFST
       ::::.   ..:.   :   : :  . ..: .  :.:. :: .:::::  .. .:.:::..
XP_006 LPFFL---VMPI---GSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN
         290             300       310       320       330         

           350       360       370       380       390       400   
pF1KB9 LLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKK
       .:    ::                                                    
XP_006 VLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKF
     340       350       360       370       380       390         

>>NP_150645 (OMIM: 104221) alpha-1A adrenergic receptor   (429 aa)
 initn: 574 init1: 276 opt: 651  Z-score: 674.2  bits: 133.9 E(85289): 8.2e-31
Smith-Waterman score: 717; 36.9% identity (66.3% similar) in 347 aa overlap (19-351:22-347)

                  10        20        30        40        50       
pF1KB9    MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSK
                            ..:  :: . .:. :::  .::: ::  .:   :::.: 
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-
               10        20        30        40        50          

        60        70        80        90        100       110      
pF1KB9 VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCV
       ::......:::.:::..  :.:..:. :. :.: ::  :::::.: :..: ::::..::.
NP_150 VTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
      60        70        80        90       100       110         

        120       130       140       150       160       170      
pF1KB9 ISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNA
       ::.::: ..: :.::   .: . ... .  .:.::..::. :. ..:..  : .: :   
NP_150 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ--P-APED---
     120       130       140       150       160           170     

        180       190       200       210       220       230      
pF1KB9 TSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAA-
           :::  :. .    :.. :.. :::.:.::..: : :.: .:... : . .  ..  
NP_150 ----ETI--CQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDK
                  180       190       200       210       220      

                  240       250       260        270       280     
pF1KB9 ---------VHAKNCQTTTGNGKPVECSQPESSFKM-SFKRETKVLKTLSVIMGVFVCCW
                .: ::  .  :.:     .. . : .. .:.:: :. :::....: :: ::
NP_150 SDSEQVTLRIHRKNAPAG-GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
        230       240        250       260       270       280     

         290       300        310       320       330        340   
pF1KB9 LPFFILNCILPFCGSGETQP-FCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFST
       ::::.   ..:.   :   : :  . ..: .  :.:. :: .:::::  .. .:.:::..
NP_150 LPFFL---VMPI---GSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN
         290             300       310       320       330         

           350       360       370       380       390       400   
pF1KB9 LLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKK
       .:    ::                                                    
NP_150 VLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKF
     340       350       360       370       380       390         

>>NP_150647 (OMIM: 104221) alpha-1A adrenergic receptor   (455 aa)
 initn: 574 init1: 276 opt: 651  Z-score: 673.9  bits: 133.9 E(85289): 8.5e-31
Smith-Waterman score: 717; 36.9% identity (66.3% similar) in 347 aa overlap (19-351:22-347)

                  10        20        30        40        50       
pF1KB9    MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSK
                            ..:  :: . .:. :::  .::: ::  .:   :::.: 
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-
               10        20        30        40        50          

        60        70        80        90        100       110      
pF1KB9 VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCV
       ::......:::.:::..  :.:..:. :. :.: ::  :::::.: :..: ::::..::.
NP_150 VTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
      60        70        80        90       100       110         

        120       130       140       150       160       170      
pF1KB9 ISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNA
       ::.::: ..: :.::   .: . ... .  .:.::..::. :. ..:..  : .: :   
NP_150 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ--P-APED---
     120       130       140       150       160           170     

        180       190       200       210       220       230      
pF1KB9 TSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAA-
           :::  :. .    :.. :.. :::.:.::..: : :.: .:... : . .  ..  
NP_150 ----ETI--CQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDK
                  180       190       200       210       220      

                  240       250       260        270       280     
pF1KB9 ---------VHAKNCQTTTGNGKPVECSQPESSFKM-SFKRETKVLKTLSVIMGVFVCCW
                .: ::  .  :.:     .. . : .. .:.:: :. :::....: :: ::
NP_150 SDSEQVTLRIHRKNAPAG-GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
        230       240        250       260       270       280     

         290       300        310       320       330        340   
pF1KB9 LPFFILNCILPFCGSGETQP-FCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFST
       ::::.   ..:.   :   : :  . ..: .  :.:. :: .:::::  .. .:.:::..
NP_150 LPFFL---VMPI---GSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN
         290             300       310       320       330         

           350       360       370       380       390       400   
pF1KB9 LLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKK
       .:    ::                                                    
NP_150 VLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKF
     340       350       360       370       380       390         

>>NP_000671 (OMIM: 104221) alpha-1A adrenergic receptor   (466 aa)
 initn: 493 init1: 276 opt: 651  Z-score: 673.8  bits: 133.9 E(85289): 8.6e-31
Smith-Waterman score: 717; 36.9% identity (66.3% similar) in 347 aa overlap (19-351:22-347)

                  10        20        30        40        50       
pF1KB9    MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSK
                            ..:  :: . .:. :::  .::: ::  .:   :::.: 
NP_000 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-
               10        20        30        40        50          

        60        70        80        90        100       110      
pF1KB9 VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCV
       ::......:::.:::..  :.:..:. :. :.: ::  :::::.: :..: ::::..::.
NP_000 VTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
      60        70        80        90       100       110         

        120       130       140       150       160       170      
pF1KB9 ISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNA
       ::.::: ..: :.::   .: . ... .  .:.::..::. :. ..:..  : .: :   
NP_000 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ--P-APED---
     120       130       140       150       160           170     

        180       190       200       210       220       230      
pF1KB9 TSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAA-
           :::  :. .    :.. :.. :::.:.::..: : :.: .:... : . .  ..  
NP_000 ----ETI--CQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDK
                  180       190       200       210       220      

                  240       250       260        270       280     
pF1KB9 ---------VHAKNCQTTTGNGKPVECSQPESSFKM-SFKRETKVLKTLSVIMGVFVCCW
                .: ::  .  :.:     .. . : .. .:.:: :. :::....: :: ::
NP_000 SDSEQVTLRIHRKNAPAG-GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
        230       240        250       260       270       280     

         290       300        310       320       330        340   
pF1KB9 LPFFILNCILPFCGSGETQP-FCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFST
       ::::.   ..:.   :   : :  . ..: .  :.:. :: .:::::  .. .:.:::..
NP_000 LPFFL---VMPI---GSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN
         290             300       310       320       330         

           350       360       370       380       390       400   
pF1KB9 LLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKK
       .:    ::                                                    
NP_000 VLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKF
     340       350       360       370       380       390         

>>XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A adrene  (475 aa)
 initn: 576 init1: 276 opt: 651  Z-score: 673.7  bits: 133.9 E(85289): 8.7e-31
Smith-Waterman score: 717; 36.9% identity (66.3% similar) in 347 aa overlap (19-351:22-347)

                  10        20        30        40        50       
pF1KB9    MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSK
                            ..:  :: . .:. :::  .::: ::  .:   :::.: 
XP_016 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-
               10        20        30        40        50          

        60        70        80        90        100       110      
pF1KB9 VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCV
       ::......:::.:::..  :.:..:. :. :.: ::  :::::.: :..: ::::..::.
XP_016 VTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
      60        70        80        90       100       110         

        120       130       140       150       160       170      
pF1KB9 ISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNA
       ::.::: ..: :.::   .: . ... .  .:.::..::. :. ..:..  : .: :   
XP_016 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ--P-APED---
     120       130       140       150       160           170     

        180       190       200       210       220       230      
pF1KB9 TSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAA-
           :::  :. .    :.. :.. :::.:.::..: : :.: .:... : . .  ..  
XP_016 ----ETI--CQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDK
                  180       190       200       210       220      

                  240       250       260        270       280     
pF1KB9 ---------VHAKNCQTTTGNGKPVECSQPESSFKM-SFKRETKVLKTLSVIMGVFVCCW
                .: ::  .  :.:     .. . : .. .:.:: :. :::....: :: ::
XP_016 SDSEQVTLRIHRKNAPAG-GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
        230       240        250       260       270       280     

         290       300        310       320       330        340   
pF1KB9 LPFFILNCILPFCGSGETQP-FCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFST
       ::::.   ..:.   :   : :  . ..: .  :.:. :: .:::::  .. .:.:::..
XP_016 LPFFL---VMPI---GSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN
         290             300       310       320       330         

           350       360       370       380       390       400   
pF1KB9 LLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKK
       .:    ::                                                    
XP_016 VLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKF
     340       350       360       370       380       390         

>>XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A adrene  (475 aa)
 initn: 576 init1: 276 opt: 651  Z-score: 673.7  bits: 133.9 E(85289): 8.7e-31
Smith-Waterman score: 717; 36.9% identity (66.3% similar) in 347 aa overlap (19-351:22-347)

                  10        20        30        40        50       
pF1KB9    MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSK
                            ..:  :: . .:. :::  .::: ::  .:   :::.: 
XP_016 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-
               10        20        30        40        50          

        60        70        80        90        100       110      
pF1KB9 VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCV
       ::......:::.:::..  :.:..:. :. :.: ::  :::::.: :..: ::::..::.
XP_016 VTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
      60        70        80        90       100       110         

        120       130       140       150       160       170      
pF1KB9 ISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNA
       ::.::: ..: :.::   .: . ... .  .:.::..::. :. ..:..  : .: :   
XP_016 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ--P-APED---
     120       130       140       150       160           170     

        180       190       200       210       220       230      
pF1KB9 TSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAA-
           :::  :. .    :.. :.. :::.:.::..: : :.: .:... : . .  ..  
XP_016 ----ETI--CQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDK
                  180       190       200       210       220      

                  240       250       260        270       280     
pF1KB9 ---------VHAKNCQTTTGNGKPVECSQPESSFKM-SFKRETKVLKTLSVIMGVFVCCW
                .: ::  .  :.:     .. . : .. .:.:: :. :::....: :: ::
XP_016 SDSEQVTLRIHRKNAPAG-GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
        230       240        250       260       270       280     

         290       300        310       320       330        340   
pF1KB9 LPFFILNCILPFCGSGETQP-FCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFST
       ::::.   ..:.   :   : :  . ..: .  :.:. :: .:::::  .. .:.:::..
XP_016 LPFFL---VMPI---GSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN
         290             300       310       320       330         

           350       360       370       380       390       400   
pF1KB9 LLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKK
       .:    ::                                                    
XP_016 VLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKF
     340       350       360       370       380       390         

>>NP_150646 (OMIM: 104221) alpha-1A adrenergic receptor   (475 aa)
 initn: 576 init1: 276 opt: 651  Z-score: 673.7  bits: 133.9 E(85289): 8.7e-31
Smith-Waterman score: 717; 36.9% identity (66.3% similar) in 347 aa overlap (19-351:22-347)

                  10        20        30        40        50       
pF1KB9    MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSK
                            ..:  :: . .:. :::  .::: ::  .:   :::.: 
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-
               10        20        30        40        50          

        60        70        80        90        100       110      
pF1KB9 VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCV
       ::......:::.:::..  :.:..:. :. :.: ::  :::::.: :..: ::::..::.
NP_150 VTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
      60        70        80        90       100       110         

        120       130       140       150       160       170      
pF1KB9 ISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNA
       ::.::: ..: :.::   .: . ... .  .:.::..::. :. ..:..  : .: :   
NP_150 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ--P-APED---
     120       130       140       150       160           170     

        180       190       200       210       220       230      
pF1KB9 TSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAA-
           :::  :. .    :.. :.. :::.:.::..: : :.: .:... : . .  ..  
NP_150 ----ETI--CQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDK
                  180       190       200       210       220      

                  240       250       260        270       280     
pF1KB9 ---------VHAKNCQTTTGNGKPVECSQPESSFKM-SFKRETKVLKTLSVIMGVFVCCW
                .: ::  .  :.:     .. . : .. .:.:: :. :::....: :: ::
NP_150 SDSEQVTLRIHRKNAPAG-GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
        230       240        250       260       270       280     

         290       300        310       320       330        340   
pF1KB9 LPFFILNCILPFCGSGETQP-FCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFST
       ::::.   ..:.   :   : :  . ..: .  :.:. :: .:::::  .. .:.:::..
NP_150 LPFFL---VMPI---GSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN
         290             300       310       320       330         

           350       360       370       380       390       400   
pF1KB9 LLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKK
       .:    ::                                                    
NP_150 VLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKF
     340       350       360       370       380       390         




446 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 09:19:28 2016 done: Sat Nov  5 09:19:29 2016
 Total Scan time:  6.670 Total Display time:  0.040

Function used was FASTA [36.3.4 Apr, 2011]
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