Result of FASTA (omim) for
pFN21AE2154
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2154, 347 aa
1>>>pF1KE2154 347 - 347 aa - 347 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4790+/-0.000344; mu= 15.8983+/- 0.021
mean_var=108.8412+/-22.722, 0's: 0 Z-trim(117.3): 438 B-trim: 1122 in 1/53
Lambda= 0.122936
statistics sampled from 28671 (29240) to 28671 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.713), E-opt: 0.2 (0.343), width: 16
Scan time: 7.260
The best scores are: opt bits E(85289)
NP_443204 (OMIM: 611289) leucine-rich alpha-2-glyc ( 347) 2317 421.7 1.2e-117
NP_821079 (OMIM: 610869) leucine-rich repeat trans ( 581) 393 80.7 8.8e-15
NP_079269 (OMIM: 610870) leucine-rich repeat trans ( 518) 383 78.9 2.8e-14
NP_001269857 (OMIM: 610870) leucine-rich repeat tr ( 519) 383 78.9 2.8e-14
NP_001128217 (OMIM: 610870) leucine-rich repeat tr ( 590) 383 78.9 3e-14
NP_001269853 (OMIM: 610870) leucine-rich repeat tr ( 590) 383 78.9 3e-14
NP_001317299 (OMIM: 610870) leucine-rich repeat tr ( 591) 383 78.9 3e-14
NP_000164 (OMIM: 153670,177820,231200,258660,60667 ( 652) 371 76.8 1.4e-13
NP_848665 (OMIM: 610462) reticulon-4 receptor-like ( 420) 365 75.6 2.2e-13
NP_938205 (OMIM: 604808,615271) leucine-rich repea ( 649) 359 74.7 6.2e-13
XP_011527506 (OMIM: 604808,615271) PREDICTED: leuc ( 649) 359 74.7 6.2e-13
NP_037413 (OMIM: 604808,615271) leucine-rich repea ( 649) 359 74.7 6.2e-13
XP_005260739 (OMIM: 604808,615271) PREDICTED: leuc ( 649) 359 74.7 6.2e-13
XP_011527507 (OMIM: 604808,615271) PREDICTED: leuc ( 649) 359 74.7 6.2e-13
NP_612490 (OMIM: 616236) chondroadherin-like prote ( 762) 349 73.0 2.4e-12
XP_005261427 (OMIM: 616236) PREDICTED: chondroadhe ( 771) 349 73.0 2.4e-12
XP_011528236 (OMIM: 616236) PREDICTED: chondroadhe ( 825) 349 73.1 2.5e-12
XP_011528235 (OMIM: 616236) PREDICTED: chondroadhe ( 830) 349 73.1 2.5e-12
XP_011528234 (OMIM: 616236) PREDICTED: chondroadhe ( 839) 349 73.1 2.5e-12
NP_004961 (OMIM: 601489,615961) insulin-like growt ( 605) 343 71.8 4.2e-12
NP_001139478 (OMIM: 601489,615961) insulin-like gr ( 643) 343 71.9 4.4e-12
NP_071426 (OMIM: 610486) leucine-rich repeat-conta ( 653) 343 71.9 4.4e-12
XP_016867994 (OMIM: 610486) PREDICTED: leucine-ric ( 653) 343 71.9 4.4e-12
XP_011514763 (OMIM: 610486) PREDICTED: leucine-ric ( 653) 343 71.9 4.4e-12
XP_005273918 (OMIM: 604806) PREDICTED: leucine-ric ( 674) 336 70.7 1.1e-11
NP_037412 (OMIM: 604806) leucine-rich repeat trans ( 674) 336 70.7 1.1e-11
XP_011543185 (OMIM: 604806) PREDICTED: leucine-ric ( 674) 336 70.7 1.1e-11
NP_001278917 (OMIM: 603104) carboxypeptidase N sub ( 545) 334 70.2 1.2e-11
NP_001073982 (OMIM: 603104) carboxypeptidase N sub ( 545) 334 70.2 1.2e-11
XP_005269337 (OMIM: 603104) PREDICTED: carboxypept ( 545) 334 70.2 1.2e-11
NP_060960 (OMIM: 606666,615311) leucine-rich repea ( 951) 326 69.0 4.6e-11
NP_001017403 (OMIM: 606653) leucine-rich repeat-co ( 967) 315 67.1 1.8e-10
NP_004479 (OMIM: 173511) platelet glycoprotein V p ( 560) 304 64.9 4.8e-10
NP_612449 (OMIM: 608843) vasorin precursor [Homo s ( 673) 305 65.2 4.8e-10
XP_016861623 (OMIM: 608868) PREDICTED: leucine-ric (1068) 307 65.7 5.2e-10
NP_056379 (OMIM: 610868) leucine-rich repeat trans ( 516) 299 64.0 8.5e-10
NP_075380 (OMIM: 181500,605566) reticulon-4 recept ( 473) 293 62.9 1.7e-09
NP_848663 (OMIM: 610461) reticulon-4 receptor-like ( 441) 290 62.3 2.3e-09
NP_001333075 (OMIM: 604807) leucine-rich repeat tr ( 660) 291 62.7 2.7e-09
XP_016876621 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 291 62.7 2.7e-09
XP_005267547 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 291 62.7 2.7e-09
XP_016876619 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 291 62.7 2.7e-09
NP_001333072 (OMIM: 604807) leucine-rich repeat tr ( 660) 291 62.7 2.7e-09
NP_001333074 (OMIM: 604807) leucine-rich repeat tr ( 660) 291 62.7 2.7e-09
NP_037363 (OMIM: 604807) leucine-rich repeat trans ( 660) 291 62.7 2.7e-09
XP_016876620 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 291 62.7 2.7e-09
XP_016876623 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 291 62.7 2.7e-09
XP_016876622 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 291 62.7 2.7e-09
XP_016876618 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 291 62.7 2.7e-09
XP_011534913 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 291 62.7 2.7e-09
>>NP_443204 (OMIM: 611289) leucine-rich alpha-2-glycopro (347 aa)
initn: 2317 init1: 2317 opt: 2317 Z-score: 2233.3 bits: 421.7 E(85289): 1.2e-117
Smith-Waterman score: 2317; 99.7% identity (99.7% similar) in 347 aa overlap (1-347:1-347)
10 20 30 40 50 60
pF1KE2 MSSWSRQRPKSPGGIQPHVSRTLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 MSSWSRQRPKSPGGIQPHVSRTLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LDLTRNALTGLPSGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLP
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 PGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 PGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNP
250 260 270 280 290 300
310 320 330 340
pF1KE2 WICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAVAKSQ
:::::::::::::::::::::::::::::::::::::::::::::::
NP_443 WICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAVAKSQ
310 320 330 340
>>NP_821079 (OMIM: 610869) leucine-rich repeat transmemb (581 aa)
initn: 243 init1: 243 opt: 393 Z-score: 386.4 bits: 80.7 E(85289): 8.8e-15
Smith-Waterman score: 393; 29.8% identity (63.6% similar) in 275 aa overlap (73-346:90-357)
50 60 70 80 90 100
pF1KE2 CQVFRSDHGSSISCQPPAEIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSN
: .. ..... : ..: .:.:: ::::
NP_821 SAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSN
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE2 GLESLSPEFLRPVPQLRVLDLTRNALTGLPSGLFQASATLDTLVLKENQLEVLEVSWLHG
. . . .::: .:: :::. : : .: : :.. : .: :. :.:... : ..
NP_821 RISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQD
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 LKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGN
. : :::. ::.:.: ...:.. :. : : .::. : :. ..:. :.:. :
NP_821 CRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWN
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE2 KLQVLGKDLLLPQPDLRYLFLNGNKL-ARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWA
:..:.:. . .:. : :.::.. : . ..:: . .:. :.:..:.:. . . .
NP_821 KISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILD
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE2 SLGQPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLL
: : . ....:: : :..:. .: ::.. : . .: ::.:. ..: ...
NP_821 S-----WISLNDISLAGNIWECSRNICSLVNWLKSFKG--LRENTIICASPKELQGVNVI
300 310 320 330 340 350
pF1KE2 AVAKSQ
..:.
NP_821 DAVKNYSICGKSTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVGATEPGPETDADA
360 370 380 390 400 410
>>NP_079269 (OMIM: 610870) leucine-rich repeat transmemb (518 aa)
initn: 336 init1: 299 opt: 383 Z-score: 377.4 bits: 78.9 E(85289): 2.8e-14
Smith-Waterman score: 392; 27.1% identity (56.5% similar) in 340 aa overlap (22-338:21-348)
10 20 30 40 50 60
pF1KE2 MSSWSRQRPKSPGGIQPHVSRTLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPA
::.:..: .:. ::.: : : :. . :. :
NP_079 MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQ----RACPKNC---RCD-GKIVYCESHA
10 20 30 40 50
70 80 90 100 110
pF1KE2 --EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQL
.:: . . . :...: .. .: .: . : ..: :.:. : . :.. . .. . .:
NP_079 FADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 RVLDLTRNALTGLPSGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRK
. : :. : .: : . :. .: .: :. :.:..:. ..::. : : : .: :.
NP_079 KELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 LPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDL
.: .. . : :::: :.:..: . . : :.:..:::: :... .. . .:
NP_079 VPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNL
180 190 200 210 220 230
240 250 260 270 280
pF1KE2 RYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPN-----------
: ..:. :.. .. : .: ::::.:.. .. : . : ::
NP_079 RSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCL--PNLQKLNLDSNKL
240 250 260 270 280
290 300 310 320 330
pF1KE2 ----------WDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKG
: .. .::: : :.... :. ::. : . ... ::::. ..:
NP_079 TNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGN--KESTMICAGPKHIQG
290 300 310 320 330 340
340
pF1KE2 QTLLAVAKSQ
.
NP_079 EKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPG
350 360 370 380 390 400
>>NP_001269857 (OMIM: 610870) leucine-rich repeat transm (519 aa)
initn: 336 init1: 299 opt: 383 Z-score: 377.4 bits: 78.9 E(85289): 2.8e-14
Smith-Waterman score: 392; 27.1% identity (56.5% similar) in 340 aa overlap (22-338:22-349)
10 20 30 40 50 60
pF1KE2 MSSWSRQRPKSPGGIQPHVSRTLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPA
::.:..: .:. ::.: : : :. . :. :
NP_001 MPGFHLITQLKGMSVVLVLLPTLLLVMLTGAQ----RACPKNC---RCD-GKIVYCESHA
10 20 30 40 50
70 80 90 100 110
pF1KE2 --EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQL
.:: . . . :...: .. .: .: . : ..: :.:. : . :.. . .. . .:
NP_001 FADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 RVLDLTRNALTGLPSGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRK
. : :. : .: : . :. .: .: :. :.:..:. ..::. : : : .: :.
NP_001 KELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 LPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDL
.: .. . : :::: :.:..: . . : :.:..:::: :... .. . .:
NP_001 VPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNL
180 190 200 210 220 230
240 250 260 270 280
pF1KE2 RYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPN-----------
: ..:. :.. .. : .: ::::.:.. .. : . : ::
NP_001 RSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCL--PNLQKLNLDSNKL
240 250 260 270 280 290
290 300 310 320 330
pF1KE2 ----------WDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKG
: .. .::: : :.... :. ::. : . ... ::::. ..:
NP_001 TNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGN--KESTMICAGPKHIQG
300 310 320 330 340
340
pF1KE2 QTLLAVAKSQ
.
NP_001 EKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPG
350 360 370 380 390 400
>>NP_001128217 (OMIM: 610870) leucine-rich repeat transm (590 aa)
initn: 336 init1: 299 opt: 383 Z-score: 376.7 bits: 78.9 E(85289): 3e-14
Smith-Waterman score: 392; 27.1% identity (56.5% similar) in 340 aa overlap (22-338:21-348)
10 20 30 40 50 60
pF1KE2 MSSWSRQRPKSPGGIQPHVSRTLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPA
::.:..: .:. ::.: : : :. . :. :
NP_001 MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQ----RACPKNC---RCD-GKIVYCESHA
10 20 30 40 50
70 80 90 100 110
pF1KE2 --EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQL
.:: . . . :...: .. .: .: . : ..: :.:. : . :.. . .. . .:
NP_001 FADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 RVLDLTRNALTGLPSGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRK
. : :. : .: : . :. .: .: :. :.:..:. ..::. : : : .: :.
NP_001 KELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 LPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDL
.: .. . : :::: :.:..: . . : :.:..:::: :... .. . .:
NP_001 VPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNL
180 190 200 210 220 230
240 250 260 270 280
pF1KE2 RYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPN-----------
: ..:. :.. .. : .: ::::.:.. .. : . : ::
NP_001 RSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCL--PNLQKLNLDSNKL
240 250 260 270 280
290 300 310 320 330
pF1KE2 ----------WDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKG
: .. .::: : :.... :. ::. : . ... ::::. ..:
NP_001 TNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGN--KESTMICAGPKHIQG
290 300 310 320 330 340
340
pF1KE2 QTLLAVAKSQ
.
NP_001 EKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPG
350 360 370 380 390 400
>>NP_001269853 (OMIM: 610870) leucine-rich repeat transm (590 aa)
initn: 336 init1: 299 opt: 383 Z-score: 376.7 bits: 78.9 E(85289): 3e-14
Smith-Waterman score: 392; 27.1% identity (56.5% similar) in 340 aa overlap (22-338:21-348)
10 20 30 40 50 60
pF1KE2 MSSWSRQRPKSPGGIQPHVSRTLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPA
::.:..: .:. ::.: : : :. . :. :
NP_001 MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQ----RACPKNC---RCD-GKIVYCESHA
10 20 30 40 50
70 80 90 100 110
pF1KE2 --EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQL
.:: . . . :...: .. .: .: . : ..: :.:. : . :.. . .. . .:
NP_001 FADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 RVLDLTRNALTGLPSGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRK
. : :. : .: : . :. .: .: :. :.:..:. ..::. : : : .: :.
NP_001 KELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 LPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDL
.: .. . : :::: :.:..: . . : :.:..:::: :... .. . .:
NP_001 VPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNL
180 190 200 210 220 230
240 250 260 270 280
pF1KE2 RYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPN-----------
: ..:. :.. .. : .: ::::.:.. .. : . : ::
NP_001 RSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCL--PNLQKLNLDSNKL
240 250 260 270 280
290 300 310 320 330
pF1KE2 ----------WDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKG
: .. .::: : :.... :. ::. : . ... ::::. ..:
NP_001 TNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGN--KESTMICAGPKHIQG
290 300 310 320 330 340
340
pF1KE2 QTLLAVAKSQ
.
NP_001 EKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPG
350 360 370 380 390 400
>>NP_001317299 (OMIM: 610870) leucine-rich repeat transm (591 aa)
initn: 336 init1: 299 opt: 383 Z-score: 376.7 bits: 78.9 E(85289): 3e-14
Smith-Waterman score: 392; 27.1% identity (56.5% similar) in 340 aa overlap (22-338:22-349)
10 20 30 40 50 60
pF1KE2 MSSWSRQRPKSPGGIQPHVSRTLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPA
::.:..: .:. ::.: : : :. . :. :
NP_001 MPGFHLITQLKGMSVVLVLLPTLLLVMLTGAQ----RACPKNC---RCD-GKIVYCESHA
10 20 30 40 50
70 80 90 100 110
pF1KE2 --EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQL
.:: . . . :...: .. .: .: . : ..: :.:. : . :.. . .. . .:
NP_001 FADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 RVLDLTRNALTGLPSGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRK
. : :. : .: : . :. .: .: :. :.:..:. ..::. : : : .: :.
NP_001 KELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 LPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDL
.: .. . : :::: :.:..: . . : :.:..:::: :... .. . .:
NP_001 VPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNL
180 190 200 210 220 230
240 250 260 270 280
pF1KE2 RYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPN-----------
: ..:. :.. .. : .: ::::.:.. .. : . : ::
NP_001 RSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCL--PNLQKLNLDSNKL
240 250 260 270 280 290
290 300 310 320 330
pF1KE2 ----------WDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKG
: .. .::: : :.... :. ::. : . ... ::::. ..:
NP_001 TNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGN--KESTMICAGPKHIQG
300 310 320 330 340
340
pF1KE2 QTLLAVAKSQ
.
NP_001 EKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPG
350 360 370 380 390 400
>>NP_000164 (OMIM: 153670,177820,231200,258660,606672) p (652 aa)
initn: 501 init1: 229 opt: 371 Z-score: 364.7 bits: 76.8 E(85289): 1.4e-13
Smith-Waterman score: 371; 34.8% identity (66.1% similar) in 233 aa overlap (91-322:26-244)
70 80 90 100 110 120
pF1KE2 EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRV
::.: :.. .. .: .: :.. . . .
NP_000 MPLLLLLLLLPSPLHPHPICEVSKVASHL-EVNCDKRNLTALPPDLPKDTT---I
10 20 30 40 50
130 140 150 160 170 180
pF1KE2 LDLTRNALTGLPSGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLP
: :..: : . . .. . : : : . .: :.:. : .:: :::: :.:..::
NP_000 LHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGT--LPVLGTLDLSHNQLQSLP
60 70 80 90 100
190 200 210 220 230
pF1KE2 PGLLAN-FTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLR
::.. . : .::.. :.: .:: ::: .:..:.:.::.:..: :: : : :.
NP_000 --LLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLE
110 120 130 140 150 160
240 250 260 270 280 290
pF1KE2 YLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGN
: : .:.:... :: ..::..:: : :..::: ..:.:...: : .: . ::
NP_000 KLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHLLPF-----AF-LHGN
170 180 190 200 210 220
300 310 320 330 340
pF1KE2 PWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAVAKSQ
::.:. .. . :::: . ....
NP_000 PWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGCP
230 240 250 260 270 280
>>NP_848665 (OMIM: 610462) reticulon-4 receptor-like 2 p (420 aa)
initn: 531 init1: 220 opt: 365 Z-score: 361.2 bits: 75.6 E(85289): 2.2e-13
Smith-Waterman score: 367; 30.6% identity (55.0% similar) in 320 aa overlap (25-343:17-302)
10 20 30 40 50 60
pF1KE2 MSSWSRQRPKSPGGIQPHVSRTLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPA
:::.: : .. : : . : ..:::
NP_848 MLPGLRRLLQAPASACLLLMLLALPLAAPSCPMLCTCYSSP--PTVSCQAN-
10 20 30 40
70 80 90 100 110 120
pF1KE2 EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRV
:.. .: .: . :.: :..: ...: : . .: .
NP_848 ------------------NFSSVPLSL---PPSTQRLFLQNNLIRTLRPGTFG--SNLLT
50 60 70 80
130 140 150 160 170
pF1KE2 LDLTRNALTGLPSGLFQASATLDTLVLKENQ-LEVLEVSWLHGLKALGHLDLSGNRLRKL
: : : :. . : :. .:. : : .:. :. :: . ..::. : : : .: .:
NP_848 LWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSL
90 100 110 120 130 140
180 190 200 210 220 230
pF1KE2 PPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLR
: ... ... :. : : ::.: : ::. .: .: :.::.:..: . .. .:
NP_848 PGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLD
150 160 170 180 190 200
240 250 260 270 280 290
pF1KE2 YLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGN
:.:.::.: : .::.:: .: .: : ::::::.: :.: :. .. . ...:
NP_848 RLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADL--PSLEF---LRLNAN
210 220 230 240 250 260
300 310 320 330 340
pF1KE2 PWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAVAKSQ
:: :: :. :.: . :..:. :: : .:. : :.
NP_848 PWACDCRARPLWAWFQRAR---VSSSDVTCATPPERQGRDLRALREADFQACPPAAPTRP
270 280 290 300 310
NP_848 GSRARGNSSSNHLYGVAEAGAPPADPSTLYRDLPAEDSRGRQGGDAPTEDDYWGGYGGED
320 330 340 350 360 370
>>NP_938205 (OMIM: 604808,615271) leucine-rich repeat tr (649 aa)
initn: 309 init1: 154 opt: 359 Z-score: 353.2 bits: 74.7 E(85289): 6.2e-13
Smith-Waterman score: 359; 28.3% identity (59.6% similar) in 307 aa overlap (40-340:57-345)
10 20 30 40 50 60
pF1KE2 KSPGGIQPHVSRTLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPAEIPGYLPAD
:.: .. .... . :... . : ..
NP_938 MAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLLKVE
30 40 50 60 70 80
70 80 90 100 110 120
pF1KE2 TVHLAVEFFN-LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNAL
..: . : : ..:.:: . ..::::. :...... . : .: :. : : :..
NP_938 RIYL---YHNSLDEFPTNL---PKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSV
90 100 110 120 130 140
130 140 150 160 170 180
pF1KE2 TG--LPSGLFQASATLDTLVLKENQLEVLEVSWLHGL-KALGHLDLSGNRLRKLPPGLLA
.. . : :. : : : :..:.: . . : :: ... .: :. ::. . :
NP_938 SAVSIEEGAFRDSNYLRLLFLSRNHLST--IPW--GLPRTIEELRLDDNRISTISSPSLQ
150 160 170 180 190
190 200 210 220 230 240
pF1KE2 NFTLLRTLDLGENQLET--LPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFL
..: :. : : : :.. : .. . ..: .: : :.: . . :: .:: :.:
NP_938 GLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVN--LPGTNLRKLYL
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE2 NGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWIC
. :.. :: .::. :::: ::.:::.:...:.:.. .: : . . .::: :
NP_938 QDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDL-----DNITQLILRNNPWYC
260 270 280 290 300
310 320 330 340
pF1KE2 DQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAVAKSQ
... . :::. :. . : .:: :.:...
NP_938 GCKMKWVRDWLQSLPVKV-NVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITT
310 320 330 340 350 360
NP_938 AIPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTSDTIHISWK
370 380 390 400 410 420
347 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 17:19:52 2016 done: Tue Nov 8 17:19:54 2016
Total Scan time: 7.260 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]