FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2620, 548 aa 1>>>pF1KE2620 548 - 548 aa - 548 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.8538+/-0.000394; mu= -1.6782+/- 0.024 mean_var=312.5326+/-61.476, 0's: 0 Z-trim(122.8): 99 B-trim: 33 in 1/59 Lambda= 0.072548 statistics sampled from 41375 (41512) to 41375 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.788), E-opt: 0.2 (0.487), width: 16 Scan time: 12.220 The best scores are: opt bits E(85289) NP_444514 (OMIM: 608021) WAP, Kazal, immunoglobuli ( 548) 3953 427.5 5.3e-119 NP_783165 (OMIM: 610895) WAP, Kazal, immunoglobuli ( 576) 1582 179.3 2.8e-44 NP_001317270 (OMIM: 610895) WAP, Kazal, immunoglob ( 483) 1279 147.6 8.6e-35 NP_001624 (OMIM: 176870) protein AMBP preproprotei ( 352) 290 43.9 0.001 NP_001257933 (OMIM: 600033) tissue factor pathway ( 186) 254 39.9 0.0086 >>NP_444514 (OMIM: 608021) WAP, Kazal, immunoglobulin, K (548 aa) initn: 3953 init1: 3953 opt: 3953 Z-score: 2257.5 bits: 427.5 E(85289): 5.3e-119 Smith-Waterman score: 3953; 100.0% identity (100.0% similar) in 548 aa overlap (1-548:1-548) 10 20 30 40 50 60 pF1KE2 MPALRPLLPLLLLLRLTSGAGLLPGLGSHPGVCPNQLSPNLWVDAQSTCERECSRDQDCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_444 MPALRPLLPLLLLLRLTSGAGLLPGLGSHPGVCPNQLSPNLWVDAQSTCERECSRDQDCA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 AAEKCCINVCGLHSCVAARFPGSPAAPTTAASCEGFVCPQQGSDCDIWDGQPVCRCRDRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_444 AAEKCCINVCGLHSCVAARFPGSPAAPTTAASCEGFVCPQQGSDCDIWDGQPVCRCRDRC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 EKEPSFTCASDGLTYYNRCYMDAEACLRGLHLHIVPCKHVLSWPPSSPGPPETTARPTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_444 EKEPSFTCASDGLTYYNRCYMDAEACLRGLHLHIVPCKHVLSWPPSSPGPPETTARPTPG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AAPVPPALYSSPSPQAVQVGGTASLHCDVSGRPPPAVTWEKQSHQRENLIMRPDQMYGNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_444 AAPVPPALYSSPSPQAVQVGGTASLHCDVSGRPPPAVTWEKQSHQRENLIMRPDQMYGNV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 VVTSIGQLVLYNARPEDAGLYTCTARNAAGLLRADFPLSVVQREPARDAAPSIPAPAECL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_444 VVTSIGQLVLYNARPEDAGLYTCTARNAAGLLRADFPLSVVQREPARDAAPSIPAPAECL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 PDVQACTGPTSPHLVLWHYDPQRGGCMTFPARGCDGAARGFETYEACQQACARGPGDACV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_444 PDVQACTGPTSPHLVLWHYDPQRGGCMTFPARGCDGAARGFETYEACQQACARGPGDACV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LPAVQGPCRGWEPRWAYSPLLQQCHPFVYGGCEGNGNNFHSRESCEDACPVPRTPPCRAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_444 LPAVQGPCRGWEPRWAYSPLLQQCHPFVYGGCEGNGNNFHSRESCEDACPVPRTPPCRAC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 RLRSKLALSLCRSDFAIVGRLTEVLEEPEAAGGIARVALEDVLKDDKMGLKFLGTKYLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_444 RLRSKLALSLCRSDFAIVGRLTEVLEEPEAAGGIARVALEDVLKDDKMGLKFLGTKYLEV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 TLSGMDWACPCPNMTAGDGPLVIMGEVRDGVAVLDAGSYVRAASEKRVKKILELLEKQAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_444 TLSGMDWACPCPNMTAGDGPLVIMGEVRDGVAVLDAGSYVRAASEKRVKKILELLEKQAC 490 500 510 520 530 540 pF1KE2 ELLNRFQD :::::::: NP_444 ELLNRFQD >>NP_783165 (OMIM: 610895) WAP, Kazal, immunoglobulin, K (576 aa) initn: 1756 init1: 535 opt: 1582 Z-score: 916.0 bits: 179.3 E(85289): 2.8e-44 Smith-Waterman score: 2193; 56.1% identity (77.0% similar) in 560 aa overlap (7-546:19-572) 10 20 30 40 pF1KE2 MPALRPLLPLLLLLRLTSGAGLLPGLG-SHPGVCPNQLSPNLWVDAQS :: ::::: . . :: . :: :.:::...::::::::: NP_783 MWAPRCRRFWSRWEQVAALLLLLLLLGVPPRSLALPPIRYSHAGICPNDMNPNLWVDAQS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE2 TCERECSRDQDCAAAEKCCINVCGLHSCVAARF---PGS--PAAPTTAASCEGFVCPQQG ::.::: ::.: . :::: :::: .::::::. :. :.. :.:. :.: ::: NP_783 TCRRECETDQECETYEKCCPNVCGTKSCVAARYMDVKGKKGPVGMPKEATCDHFMCLQQG 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE2 SDCDIWDGQPVCRCRDRCEKEPSFTCASDGLTYYNRCYMDAEACLRGLHLHIVPCKHVLS :.::::::::::.:.::::::::::::::::::::::::::::: .:. : .: :.. .. NP_783 SECDIWDGQPVCKCKDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAVVTCRYHFT 130 140 150 160 170 180 170 180 190 200 210 pF1KE2 WPPSSPGPPETTARPTPGAAPVP------PALYSSPSPQAVQVGGTASLHCDVSGRPPPA :: .:: ::::: .:: .. .: ::: ..: :.: .: :.:. ::: ::: : NP_783 WPNTSPPPPETTMHPTTASPETPELDMAAPALLNNPVHQSVTMGETVSFLCDVVGRPRPE 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE2 VTWEKQSHQRENLIMRPDQMYGNVVVTSIGQLVLYNARPEDAGLYTCTARNAAGLLRADF .::::: ..:::..:::... ::::::.:.:::.:::. .:::.:::::::.::.::::: NP_783 ITWEKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNAQLQDAGIYTCTARNVAGVLRADF 250 260 270 280 290 300 280 290 300 310 320 pF1KE2 PLSVVQREPARDAAPSIPA----PA-ECL--PDVQACTGPTSPHLVLWHYDPQRGGCMTF :::::. . : .. : : :: ::: :: . : : . . ::.: : ..:.:: NP_783 PLSVVRGHQAAATSESSPNGTAFPAAECLKPPDSEDC-GEEQTR---WHFDAQANNCLTF 310 320 330 340 350 330 340 350 360 370 380 pF1KE2 PARGCDGAARGFETYEACQQACARGPGDACVLPAVQGPCRGWEPRWAYSPLLQQCHPFVY : :::::::. :: :: :: :::.::::... :::::. ::. ::: NP_783 TFGHCHRNLNHFETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQCQSFVY 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE2 GGCEGNGNNFHSRESCEDACPVPR-TPPCRACRLRSKLALSLCRSDFAIVGRLTEVLEEP ::::::::::.:::.::..:: :: . ::::. :.::. :.:::::.:.::..:. ::: NP_783 GGCEGNGNNFESREACEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSELTEEP 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE2 EAAGGIARVALEDVLKDDKMGLKFLGTKYLEVTLSGMDWACPCPNMTAGDGPLVIMGEVR .. : : :....::::.:::::::: . ::::: .::::::::.:... ::.::::: NP_783 DS--GRALVTVDEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVD 480 490 500 510 520 530 510 520 530 540 pF1KE2 DGVAVLDAGSYVRAASEKRVKKILELLEKQACELLNRFQD :.:.: :.: :.: .::.:. :...:..:..:..: NP_783 GGMAMLRPDSFVGASSARRVRKLREVMHKKTCDVLKEFLGLH 540 550 560 570 >>NP_001317270 (OMIM: 610895) WAP, Kazal, immunoglobulin (483 aa) initn: 1451 init1: 535 opt: 1279 Z-score: 745.6 bits: 147.6 E(85289): 8.6e-35 Smith-Waterman score: 1890; 56.0% identity (77.8% similar) in 477 aa overlap (84-546:9-479) 60 70 80 90 100 110 pF1KE2 SRDQDCAAAEKCCINVCGLHSCVAARFPGSPAAPTTAASCEGFVCPQQGSDCDIWDGQPV :.. :.:. :.: ::::.::::::::: NP_001 MDVKGKKGPVGMPKEATCDHFMCLQQGSECDIWDGQPV 10 20 30 120 130 140 150 160 170 pF1KE2 CRCRDRCEKEPSFTCASDGLTYYNRCYMDAEACLRGLHLHIVPCKHVLSWPPSSPGPPET :.:.::::::::::::::::::::::::::::: .:. : .: :.. ..:: .:: :::: NP_001 CKCKDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAVVTCRYHFTWPNTSPPPPET 40 50 60 70 80 90 180 190 200 210 220 pF1KE2 TARPTPGAAPVP------PALYSSPSPQAVQVGGTASLHCDVSGRPPPAVTWEKQSHQRE : .:: .. .: ::: ..: :.: .: :.:. ::: ::: : .::::: ..:: NP_001 TMHPTTASPETPELDMAAPALLNNPVHQSVTMGETVSFLCDVVGRPRPEITWEKQLEDRE 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE2 NLIMRPDQMYGNVVVTSIGQLVLYNARPEDAGLYTCTARNAAGLLRADFPLSVVQREPAR :..:::... ::::::.:.:::.:::. .:::.:::::::.::.::::::::::. . : NP_001 NVVMRPNHVRGNVVVTNIAQLVIYNAQLQDAGIYTCTARNVAGVLRADFPLSVVRGHQAA 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE2 DAAPSIPA----PA-ECL--PDVQACTGPTSPHLVLWHYDPQRGGCMTFPARGCDGAARG .. : : :: ::: :: . : : . . ::.: : ..:.:: : NP_001 ATSESSPNGTAFPAAECLKPPDSEDC-GEEQTR---WHFDAQANNCLTFTFGHCHRNLNH 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE2 FETYEACQQACARGPGDACVLPAVQGPCRGWEPRWAYSPLLQQCHPFVYGGCEGNGNNFH :::::::. :: :: :: :::.::::... :::::. ::. :::::::::::::. NP_001 FETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCEGNGNNFE 280 290 300 310 320 330 410 420 430 440 450 pF1KE2 SRESCEDACPVPR-TPPCRACRLRSKLALSLCRSDFAIVGRLTEVLEEPEAAGGIARVAL :::.::..:: :: . ::::. :.::. :.:::::.:.::..:. :::.. : : :.. NP_001 SREACEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSELTEEPDS--GRALVTV 340 350 360 370 380 390 460 470 480 490 500 510 pF1KE2 EDVLKDDKMGLKFLGTKYLEVTLSGMDWACPCPNMTAGDGPLVIMGEVRDGVAVLDAGSY ..::::.:::::::: . ::::: .::::::::.:... ::.::::: :.:.: :. NP_001 DEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVDGGMAMLRPDSF 400 410 420 430 440 450 520 530 540 pF1KE2 VRAASEKRVKKILELLEKQACELLNRFQD : :.: .::.:. :...:..:..:..: NP_001 VGASSARRVRKLREVMHKKTCDVLKEFLGLH 460 470 480 >>NP_001624 (OMIM: 176870) protein AMBP preproprotein [H (352 aa) initn: 346 init1: 220 opt: 290 Z-score: 187.9 bits: 43.9 E(85289): 0.001 Smith-Waterman score: 290; 41.1% identity (62.6% similar) in 107 aa overlap (306-412:240-340) 280 290 300 310 320 330 pF1KE2 FPLSVVQREPARDAAPSIPAPAECLPDVQACTGPTSPHLVLWHYDPQRGGCMTFPARGCD : : :: .. :. .: :: :: NP_001 QEEEGSGGGQLVTEVTKKEDSCQLGYSAGPCMGMTSRYF----YNGTSMACETFQYGGCM 210 220 230 240 250 260 340 350 360 370 380 390 pF1KE2 GAARGFETYEACQQACARGPGDACVLPAVQGPCRGWEPRWAYSPLLQQCHPFVYGGCEGN : . .: : . : :.: : . :: :: :.::::.. ::.. . .: : ::::.:: NP_001 GNGNNFVTEKECLQTC-RTVA-ACNLPIVRGPCRAFIQLWAFDAVKGKCVLFPYGGCQGN 270 280 290 300 310 320 400 410 420 430 440 450 pF1KE2 GNNFHSRESCEDACPVPRTPPCRACRLRSKLALSLCRSDFAIVGRLTEVLEEPEAAGGIA ::.:.:.. :.. : :: NP_001 GNKFYSEKECREYCGVPGDGDEELLRFSN 330 340 350 >>NP_001257933 (OMIM: 600033) tissue factor pathway inhi (186 aa) initn: 244 init1: 219 opt: 254 Z-score: 171.1 bits: 39.9 E(85289): 0.0086 Smith-Waterman score: 254; 33.9% identity (59.5% similar) in 121 aa overlap (357-476:34-152) 330 340 350 360 370 380 pF1KE2 MTFPARGCDGAARGFETYEACQQACARGPGDACVLPAVQGPCRGWEPRWAYSPLLQQCHP . :.:: ::::. :. :. :.:. NP_001 ARPLGLSILLLFLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQ 10 20 30 40 50 60 390 400 410 420 430 440 pF1KE2 FVYGGCEGNGNNFHSRESCEDAC-PVPRTPPCRACRLRSKLALSLCRSDFAIVGRLTEVL :.:::::::.:::.. :.:.::: . ..: ..:::. .. . : :. . NP_001 FLYGGCEGNANNFYTWEACDDACWRIEKVP--KVCRLQVSVDDQCEGSTEKYFFNLSSMT 70 80 90 100 110 120 450 460 470 480 490 500 pF1KE2 EEPEAAGGIARVALEDVLKDDKMGLKFLGTKYLEVTLSGMDWACPCPNMTAGDGPLVIMG : .:: : .:. . :. . : . : NP_001 CEKFFSGGCHRNRIENRFPDEATCMGFCAPKKNTEPVMLSPILAVEGMTITLLAGRIANV 130 140 150 160 170 180 510 520 530 540 pF1KE2 EVRDGVAVLDAGSYVRAASEKRVKKILELLEKQACELLNRFQD NP_001 HVQKL 548 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 17:15:33 2016 done: Tue Nov 8 17:15:34 2016 Total Scan time: 12.220 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]