FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3363, 1070 aa 1>>>pF1KE3363 1070 - 1070 aa - 1070 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.0029+/-0.000654; mu= -3.7446+/- 0.039 mean_var=784.0344+/-186.022, 0's: 0 Z-trim(116.9): 971 B-trim: 0 in 0/59 Lambda= 0.045804 statistics sampled from 27347 (28476) to 27347 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.668), E-opt: 0.2 (0.334), width: 16 Scan time: 13.380 The best scores are: opt bits E(85289) NP_002812 (OMIM: 601890) inactive tyrosine-protein (1070) 7288 499.3 4.8e-140 NP_001257327 (OMIM: 601890) inactive tyrosine-prot (1078) 7121 488.3 1e-136 NP_690621 (OMIM: 601890) inactive tyrosine-protein (1014) 4304 302.1 1.1e-80 NP_690620 (OMIM: 601890) inactive tyrosine-protein ( 940) 3595 255.2 1.3e-66 XP_011513068 (OMIM: 601890) PREDICTED: inactive ty ( 948) 3595 255.2 1.3e-66 NP_690619 (OMIM: 601890) inactive tyrosine-protein (1030) 3588 254.8 1.9e-66 XP_011513067 (OMIM: 601890) PREDICTED: inactive ty (1038) 3588 254.8 1.9e-66 NP_001007793 (OMIM: 155240,191315,256800) high aff ( 760) 730 65.7 1.1e-09 NP_001012331 (OMIM: 155240,191315,256800) high aff ( 790) 730 65.7 1.2e-09 NP_002520 (OMIM: 155240,191315,256800) high affini ( 796) 725 65.4 1.5e-09 NP_996844 (OMIM: 151520) leukocyte tyrosine kinase ( 803) 713 64.6 2.6e-09 NP_002335 (OMIM: 151520) leukocyte tyrosine kinase ( 864) 713 64.7 2.7e-09 XP_016870223 (OMIM: 208150,601296,616325) PREDICTE ( 791) 712 64.6 2.7e-09 NP_004295 (OMIM: 105590,613014) ALK tyrosine kinas (1620) 715 65.3 3.3e-09 NP_001159752 (OMIM: 208150,601296,616325) muscle, ( 783) 706 64.1 3.5e-09 XP_011534355 (OMIM: 165020) PREDICTED: proto-oncog (2299) 713 65.4 4.4e-09 XP_016866662 (OMIM: 165020) PREDICTED: proto-oncog (2333) 713 65.4 4.4e-09 XP_016866661 (OMIM: 165020) PREDICTED: proto-oncog (2334) 713 65.4 4.4e-09 XP_006715611 (OMIM: 165020) PREDICTED: proto-oncog (2342) 713 65.4 4.4e-09 XP_011534354 (OMIM: 165020) PREDICTED: proto-oncog (2343) 713 65.4 4.4e-09 NP_002935 (OMIM: 165020) proto-oncogene tyrosine-p (2347) 713 65.4 4.4e-09 XP_011534353 (OMIM: 165020) PREDICTED: proto-oncog (2348) 713 65.4 4.4e-09 XP_011534352 (OMIM: 165020) PREDICTED: proto-oncog (2356) 713 65.4 4.4e-09 XP_011534351 (OMIM: 165020) PREDICTED: proto-oncog (2357) 713 65.4 4.4e-09 XP_011519859 (OMIM: 151520) PREDICTED: leukocyte t ( 824) 694 63.4 6.2e-09 XP_016877671 (OMIM: 151520) PREDICTED: leukocyte t ( 837) 694 63.4 6.3e-09 XP_011519858 (OMIM: 151520) PREDICTED: leukocyte t ( 880) 694 63.4 6.4e-09 XP_016877670 (OMIM: 151520) PREDICTED: leukocyte t ( 885) 694 63.4 6.4e-09 NP_001018074 (OMIM: 600456,613886) BDNF/NT-3 growt ( 822) 688 63.0 8.2e-09 XP_016870243 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 688 63.0 8.2e-09 XP_016870242 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 688 63.0 8.2e-09 XP_011517020 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 688 63.0 8.2e-09 XP_016870241 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 688 63.0 8.2e-09 XP_016877741 (OMIM: 191316) PREDICTED: NT-3 growth ( 448) 680 62.0 8.7e-09 XP_016877740 (OMIM: 191316) PREDICTED: NT-3 growth ( 456) 680 62.0 8.8e-09 XP_016877735 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 680 62.4 1.1e-08 XP_016877734 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 680 62.4 1.1e-08 XP_016877733 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 680 62.4 1.1e-08 XP_016877732 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 680 62.4 1.1e-08 XP_016877730 (OMIM: 191316) PREDICTED: NT-3 growth ( 763) 680 62.4 1.1e-08 XP_006720607 (OMIM: 191316) PREDICTED: NT-3 growth ( 817) 680 62.5 1.2e-08 NP_001230030 (OMIM: 191316) NT-3 growth factor rec ( 817) 680 62.5 1.2e-08 XP_006720606 (OMIM: 191316) PREDICTED: NT-3 growth ( 825) 680 62.5 1.2e-08 XP_016877729 (OMIM: 191316) PREDICTED: NT-3 growth ( 825) 680 62.5 1.2e-08 NP_002521 (OMIM: 191316) NT-3 growth factor recept ( 825) 680 62.5 1.2e-08 XP_005252061 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 679 62.4 1.2e-08 XP_005252060 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 679 62.4 1.2e-08 NP_006171 (OMIM: 600456,613886) BDNF/NT-3 growth f ( 838) 679 62.4 1.2e-08 XP_016870240 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 679 62.4 1.2e-08 XP_005252058 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 679 62.4 1.2e-08 >>NP_002812 (OMIM: 601890) inactive tyrosine-protein kin (1070 aa) initn: 7288 init1: 7288 opt: 7288 Z-score: 2635.3 bits: 499.3 E(85289): 4.8e-140 Smith-Waterman score: 7288; 100.0% identity (100.0% similar) in 1070 aa overlap (1-1070:1-1070) 10 20 30 40 50 60 pF1KE3 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KE3 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP :::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1030 1040 1050 1060 1070 >>NP_001257327 (OMIM: 601890) inactive tyrosine-protein (1078 aa) initn: 7119 init1: 7119 opt: 7121 Z-score: 2575.6 bits: 488.3 E(85289): 1e-136 Smith-Waterman score: 7121; 98.4% identity (98.9% similar) in 1065 aa overlap (6-1070:17-1078) 10 20 30 40 pF1KE3 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRA :: . ...: . : ::::::::::::::::::::::: NP_001 MGSFLSGEKRPSAPTVGSAMEKKEFPTPPGRVGP---GTQTAIVFIKQPSSQDALQGRRA 10 20 30 40 50 50 60 70 80 90 100 pF1KE3 LLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTG 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE3 EEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPL 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE3 SDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE3 APQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLT 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE3 QVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGL 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE3 PEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE3 TVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRIN 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE3 SVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGR 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE3 EKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVA 540 550 560 570 580 590 590 600 610 620 630 640 pF1KE3 VFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSL 600 610 620 630 640 650 650 660 670 680 690 700 pF1KE3 VIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSV 660 670 680 690 700 710 710 720 730 740 750 760 pF1KE3 GAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVAL 720 730 740 750 760 770 770 780 790 800 810 820 pF1KE3 TSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLV 780 790 800 810 820 830 830 840 850 860 870 880 pF1KE3 KSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRI 840 850 860 870 880 890 890 900 910 920 930 940 pF1KE3 SKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSAL 900 910 920 930 940 950 950 960 970 980 990 1000 pF1KE3 GLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGG 960 970 980 990 1000 1010 1010 1020 1030 1040 1050 1060 pF1KE3 QADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSK 1020 1030 1040 1050 1060 1070 1070 pF1KE3 P : NP_001 P >>NP_690621 (OMIM: 601890) inactive tyrosine-protein kin (1014 aa) initn: 4302 init1: 4302 opt: 4304 Z-score: 1569.8 bits: 302.1 E(85289): 1.1e-80 Smith-Waterman score: 6778; 94.8% identity (94.8% similar) in 1070 aa overlap (1-1070:1-1014) 10 20 30 40 50 60 pF1KE3 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG :::::::::::::::::::::::::: NP_690 TTVYQGHTALLQCEAQGDPKPLIQWK---------------------------------- 610 620 670 680 690 700 710 720 pF1KE3 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL :::::::::::::::::::::::::::::::::::::: NP_690 ----------------------DKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 630 640 650 660 730 740 750 760 770 780 pF1KE3 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 670 680 690 700 710 720 790 800 810 820 830 840 pF1KE3 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 730 740 750 760 770 780 850 860 870 880 890 900 pF1KE3 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 790 800 810 820 830 840 910 920 930 940 950 960 pF1KE3 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 850 860 870 880 890 900 970 980 990 1000 1010 1020 pF1KE3 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 910 920 930 940 950 960 1030 1040 1050 1060 1070 pF1KE3 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP :::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 970 980 990 1000 1010 >>NP_690620 (OMIM: 601890) inactive tyrosine-protein kin (940 aa) initn: 3587 init1: 3587 opt: 3595 Z-score: 1316.9 bits: 255.2 E(85289): 1.3e-66 Smith-Waterman score: 6108; 87.8% identity (87.9% similar) in 1070 aa overlap (1-1070:1-940) 10 20 30 40 50 60 pF1KE3 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD ::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA----------- 370 380 390 400 430 440 450 460 470 480 pF1KE3 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR NP_690 ------------------------------------------------------------ 490 500 510 520 530 540 pF1KE3 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD . NP_690 -----------------------------------------------------------N 410 550 560 570 580 590 600 pF1KE3 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 420 430 440 450 460 470 610 620 630 640 650 660 pF1KE3 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 480 490 500 510 520 530 670 680 690 700 710 720 pF1KE3 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 540 550 560 570 580 590 730 740 750 760 770 780 pF1KE3 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 600 610 620 630 640 650 790 800 810 820 830 840 pF1KE3 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 660 670 680 690 700 710 850 860 870 880 890 900 pF1KE3 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 720 730 740 750 760 770 910 920 930 940 950 960 pF1KE3 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 780 790 800 810 820 830 970 980 990 1000 1010 1020 pF1KE3 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 840 850 860 870 880 890 1030 1040 1050 1060 1070 pF1KE3 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP :::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 900 910 920 930 940 >>XP_011513068 (OMIM: 601890) PREDICTED: inactive tyrosi (948 aa) initn: 3587 init1: 3587 opt: 3595 Z-score: 1316.9 bits: 255.2 E(85289): 1.3e-66 Smith-Waterman score: 5941; 86.1% identity (86.7% similar) in 1065 aa overlap (6-1070:17-948) 10 20 30 40 pF1KE3 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRA :: . ...: . : ::::::::::::::::::::::: XP_011 MGSFLSGEKRPSAPTVGSAMEKKEFPTPPGRVGP---GTQTAIVFIKQPSSQDALQGRRA 10 20 30 40 50 50 60 70 80 90 100 pF1KE3 LLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTG 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE3 EEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPL 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE3 SDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE3 APQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLT 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE3 QVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGL 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE3 PEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE3 TVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRIN XP_011 ------------------------------------------------------------ 470 480 490 500 510 520 pF1KE3 SVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGR XP_011 ------------------------------------------------------------ 530 540 550 560 570 580 pF1KE3 EKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVA .::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ----------NGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVA 420 430 440 450 460 590 600 610 620 630 640 pF1KE3 VFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSL 470 480 490 500 510 520 650 660 670 680 690 700 pF1KE3 VIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSV 530 540 550 560 570 580 710 720 730 740 750 760 pF1KE3 GAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVAL 590 600 610 620 630 640 770 780 790 800 810 820 pF1KE3 TSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLV 650 660 670 680 690 700 830 840 850 860 870 880 pF1KE3 KSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRI 710 720 730 740 750 760 890 900 910 920 930 940 pF1KE3 SKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSAL 770 780 790 800 810 820 950 960 970 980 990 1000 pF1KE3 GLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGG 830 840 850 860 870 880 1010 1020 1030 1040 1050 1060 pF1KE3 QADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSK 890 900 910 920 930 940 1070 pF1KE3 P : XP_011 P >>NP_690619 (OMIM: 601890) inactive tyrosine-protein kin (1030 aa) initn: 7033 init1: 3588 opt: 3588 Z-score: 1314.0 bits: 254.8 E(85289): 1.9e-66 Smith-Waterman score: 6908; 96.3% identity (96.3% similar) in 1070 aa overlap (1-1070:1-1030) 10 20 30 40 50 60 pF1KE3 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD ::::::::::::::::::: : NP_690 CMSSTPAGSIEAQARVQVL----------------------------------------D 490 500 550 560 570 580 590 600 pF1KE3 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 510 520 530 540 550 560 610 620 630 640 650 660 pF1KE3 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 570 580 590 600 610 620 670 680 690 700 710 720 pF1KE3 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 630 640 650 660 670 680 730 740 750 760 770 780 pF1KE3 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 690 700 710 720 730 740 790 800 810 820 830 840 pF1KE3 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 750 760 770 780 790 800 850 860 870 880 890 900 pF1KE3 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 810 820 830 840 850 860 910 920 930 940 950 960 pF1KE3 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 870 880 890 900 910 920 970 980 990 1000 1010 1020 pF1KE3 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 930 940 950 960 970 980 1030 1040 1050 1060 1070 pF1KE3 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP :::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 990 1000 1010 1020 1030 >>XP_011513067 (OMIM: 601890) PREDICTED: inactive tyrosi (1038 aa) initn: 6864 init1: 3588 opt: 3588 Z-score: 1314.0 bits: 254.8 E(85289): 1.9e-66 Smith-Waterman score: 6741; 94.6% identity (95.1% similar) in 1065 aa overlap (6-1070:17-1038) 10 20 30 40 pF1KE3 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRA :: . ...: . : ::::::::::::::::::::::: XP_011 MGSFLSGEKRPSAPTVGSAMEKKEFPTPPGRVGP---GTQTAIVFIKQPSSQDALQGRRA 10 20 30 40 50 50 60 70 80 90 100 pF1KE3 LLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTG 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE3 EEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPL 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE3 SDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE3 APQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLT 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE3 QVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGL 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE3 PEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE3 TVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRIN 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE3 SVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGR :::::::::::::::::::::::::::::: XP_011 SVEVYDGTWYRCMSSTPAGSIEAQARVQVL------------------------------ 480 490 500 530 540 550 560 570 580 pF1KE3 EKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVA :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ----------DGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVA 510 520 530 540 550 590 600 610 620 630 640 pF1KE3 VFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSL 560 570 580 590 600 610 650 660 670 680 690 700 pF1KE3 VIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSV 620 630 640 650 660 670 710 720 730 740 750 760 pF1KE3 GAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVAL 680 690 700 710 720 730 770 780 790 800 810 820 pF1KE3 TSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLV 740 750 760 770 780 790 830 840 850 860 870 880 pF1KE3 KSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRI 800 810 820 830 840 850 890 900 910 920 930 940 pF1KE3 SKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSAL 860 870 880 890 900 910 950 960 970 980 990 1000 pF1KE3 GLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGG 920 930 940 950 960 970 1010 1020 1030 1040 1050 1060 pF1KE3 QADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSK 980 990 1000 1010 1020 1030 1070 pF1KE3 P : XP_011 P >>NP_001007793 (OMIM: 155240,191315,256800) high affinit (760 aa) initn: 701 init1: 241 opt: 730 Z-score: 294.5 bits: 65.7 E(85289): 1.1e-09 Smith-Waterman score: 810; 29.6% identity (58.9% similar) in 582 aa overlap (510-1061:171-745) 480 490 500 510 520 530 pF1KE3 RCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKW--- :. .. .. . :.. :: : NP_001 PEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILT 150 160 170 180 190 200 540 550 560 570 580 590 pF1KE3 ERADGSSLPEWVTDNAGTLHFARVTRD-DAGNYTCIASNGPQGQIRAHVQLTVAVFITFK : ..... . . : .: :: : . : :: : : : ::.: .: : ..: NP_001 ELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDV-G--RAEV--SVQVNVSFP 210 220 230 240 250 600 610 620 630 640 pF1KE3 VEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTK------LGPRMH-IFQNGS . . :. . : . ..:.: : ..: . .:. :. : : . ..: NP_001 ASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGC 260 270 280 290 300 310 650 660 670 680 690 700 pF1KE3 LVIHDVAPEDSGRYTCIAGN-----SCNI--KHTEAPL-YVVDKPVPEESEGPGSPPPYK : ... . ..: :: .:.: : .: . :. . . :.:. . :.: : NP_001 LRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKK 320 330 340 350 360 370 710 720 730 740 750 pF1KE3 MIQTIGLSVGAAVAYIIAV-LGLMFYCKKRC--KAKRLQKQPEGEEPEMECLNGGPLQNG .:.::....: . . :. .. ..: . : ..: :: . ... NP_001 DETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL 380 390 400 410 420 430 760 770 780 790 800 810 pF1KE3 QPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQG :. : ..: . . . : . :. : .. ::.. ::.::::. .. NP_001 GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHN 440 450 460 470 480 490 820 830 840 850 860 870 pF1KE3 LEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEY : . :: ::.:. .:. . ::.:: :.. :.: ..::..:.: :..: ::.:: NP_001 LLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEY 500 510 520 530 540 550 880 890 900 910 920 930 pF1KE3 VDLGDLKQFLRISKSKDEKLKSQ-------PLSTKQKVALCTQVALGMEHLSNNRFVHKD . :::..::: :.. : :: . ::. : .:. .::: :: .:.. .:::.: NP_001 MRHGDLNRFLR-SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRD 560 570 580 590 600 610 940 950 960 970 980 pF1KE3 LAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFR-QAWVPLRWMSPEAILEGDFSTKSDV ::.:::::. ::.. .:.:.:.:...::. .. .:.::: ::.:: :.:.::: NP_001 LATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDV 620 630 640 650 660 670 990 1000 1010 1020 1030 1040 pF1KE3 WAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPK :.:::..::.::.:..: .. :.. . :. .: .:..:: ..: .:. :: :. NP_001 WSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQ 680 690 700 710 720 730 1050 1060 1070 pF1KE3 DRPSFSEIASALGDSTVDSKP .: :.... . : NP_001 QRHSIKDVHARLQALAQAPPVYLDVLG 740 750 760 >>NP_001012331 (OMIM: 155240,191315,256800) high affinit (790 aa) initn: 701 init1: 241 opt: 730 Z-score: 294.4 bits: 65.7 E(85289): 1.2e-09 Smith-Waterman score: 810; 29.6% identity (58.9% similar) in 582 aa overlap (510-1061:201-775) 480 490 500 510 520 530 pF1KE3 RCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKW--- :. .. .. . :.. :: : NP_001 PEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILT 180 190 200 210 220 230 540 550 560 570 580 590 pF1KE3 ERADGSSLPEWVTDNAGTLHFARVTRD-DAGNYTCIASNGPQGQIRAHVQLTVAVFITFK : ..... . . : .: :: : . : :: : : : ::.: .: : ..: NP_001 ELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDV-G--RAEV--SVQVNVSFP 240 250 260 270 280 600 610 620 630 640 pF1KE3 VEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTK------LGPRMH-IFQNGS . . :. . : . ..:.: : ..: . .:. :. : : . ..: NP_001 ASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGC 290 300 310 320 330 340 650 660 670 680 690 700 pF1KE3 LVIHDVAPEDSGRYTCIAGN-----SCNI--KHTEAPL-YVVDKPVPEESEGPGSPPPYK : ... . ..: :: .:.: : .: . :. . . :.:. . :.: : NP_001 LRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKK 350 360 370 380 390 400 710 720 730 740 750 pF1KE3 MIQTIGLSVGAAVAYIIAV-LGLMFYCKKRC--KAKRLQKQPEGEEPEMECLNGGPLQNG .:.::....: . . :. .. ..: . : ..: :: . ... NP_001 DETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL 410 420 430 440 450 460 760 770 780 790 800 810 pF1KE3 QPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQG :. : ..: . . . : . :. : .. ::.. ::.::::. .. NP_001 GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHN 470 480 490 500 510 520 820 830 840 850 860 870 pF1KE3 LEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEY : . :: ::.:. .:. . ::.:: :.. :.: ..::..:.: :..: ::.:: NP_001 LLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEY 530 540 550 560 570 580 880 890 900 910 920 930 pF1KE3 VDLGDLKQFLRISKSKDEKLKSQ-------PLSTKQKVALCTQVALGMEHLSNNRFVHKD . :::..::: :.. : :: . ::. : .:. .::: :: .:.. .:::.: NP_001 MRHGDLNRFLR-SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRD 590 600 610 620 630 640 940 950 960 970 980 pF1KE3 LAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFR-QAWVPLRWMSPEAILEGDFSTKSDV ::.:::::. ::.. .:.:.:.:...::. .. .:.::: ::.:: :.:.::: NP_001 LATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDV 650 660 670 680 690 700 990 1000 1010 1020 1030 1040 pF1KE3 WAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPK :.:::..::.::.:..: .. :.. . :. .: .:..:: ..: .:. :: :. NP_001 WSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQ 710 720 730 740 750 760 1050 1060 1070 pF1KE3 DRPSFSEIASALGDSTVDSKP .: :.... . : NP_001 QRHSIKDVHARLQALAQAPPVYLDVLG 770 780 790 >>NP_002520 (OMIM: 155240,191315,256800) high affinity n (796 aa) initn: 684 init1: 241 opt: 725 Z-score: 292.6 bits: 65.4 E(85289): 1.5e-09 Smith-Waterman score: 790; 29.7% identity (58.4% similar) in 589 aa overlap (510-1061:201-781) 480 490 500 510 520 530 pF1KE3 RCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKW--- :. .. .. . :.. :: : NP_002 PEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILT 180 190 200 210 220 230 540 550 560 570 580 590 pF1KE3 ERADGSSLPEWVTDNAGTLHFARVTRD-DAGNYTCIASNGPQGQIRAHVQLTVAVFITFK : ..... . . : .: :: : . : :: : : : ::.: .: : ..: NP_002 ELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDV-G--RAEV--SVQVNVSFP 240 250 260 270 280 600 610 620 630 640 pF1KE3 VEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTK------LGPRMH-IFQNGS . . :. . : . ..:.: : ..: . .:. :. : : . ..: NP_002 ASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGC 290 300 310 320 330 340 650 660 670 680 690 pF1KE3 LVIHDVAPEDSGRYTCIAGN-----SCNIK----------HTEAPLYVVDKPVPEESEGP : ... . ..: :: .:.: : .: . : :. : .:: .: . NP_002 LRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTS- 350 360 370 380 390 400 700 710 720 730 740 750 pF1KE3 GSPPPYKMIQTIGLSVGAAVAYIIAV-LGLMFYCKKRC--KAKRLQKQPEGEEPEMECLN :.: : .:.::....: . . :. .. ..: . : ..: :: NP_002 GDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAM 410 420 430 440 450 460 760 770 780 790 800 810 pF1KE3 GGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEV . ... :. : ..: . . . : . :. : .. ::.. ::.: NP_002 SLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKV 470 480 490 500 510 520 820 830 840 850 860 870 pF1KE3 FLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEP :::. ..: . :: ::.:. .:. . ::.:: :.. :.: ..::..:.: :..: NP_002 FLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRP 530 540 550 560 570 580 880 890 900 910 920 pF1KE3 HYMVLEYVDLGDLKQFLRISKSKDEKLKSQ-------PLSTKQKVALCTQVALGMEHLSN ::.::. :::..::: :.. : :: . ::. : .:. .::: :: .:.. NP_002 LLMVFEYMRHGDLNRFLR-SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG 590 600 610 620 630 640 930 940 950 960 970 980 pF1KE3 NRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFR-QAWVPLRWMSPEAILEGD .:::.:::.:::::. ::.. .:.:.:.:...::. .. .:.::: ::.:: NP_002 LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRK 650 660 670 680 690 700 990 1000 1010 1020 1030 1040 pF1KE3 FSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQR :.:.::::.:::..::.::.:..: .. :.. . :. .: .:..:: ..: .:. NP_002 FTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRG 710 720 730 740 750 760 1050 1060 1070 pF1KE3 CWALSPKDRPSFSEIASALGDSTVDSKP :: :..: :.... . : NP_002 CWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 770 780 790 1070 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 16 15:01:11 2016 done: Wed Nov 16 15:01:13 2016 Total Scan time: 13.380 Total Display time: 0.260 Function used was FASTA [36.3.4 Apr, 2011]