FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2588, 1143 aa 1>>>pF1KE2588 1143 - 1143 aa - 1143 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5529+/-0.000435; mu= 17.7267+/- 0.027 mean_var=174.9066+/-38.696, 0's: 0 Z-trim(115.6): 153 B-trim: 2993 in 2/54 Lambda= 0.096978 statistics sampled from 25886 (26097) to 25886 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.306), width: 16 Scan time: 11.660 The best scores are: opt bits E(85289) NP_001239053 (OMIM: 607505) PAS domain-containing (1143) 7738 1096.5 0 XP_011509132 (OMIM: 607505) PREDICTED: PAS domain- (1330) 7573 1073.5 0 XP_011509130 (OMIM: 607505) PREDICTED: PAS domain- (1330) 7573 1073.5 0 NP_001239048 (OMIM: 607505) PAS domain-containing (1330) 7573 1073.5 0 XP_011509131 (OMIM: 607505) PREDICTED: PAS domain- (1330) 7573 1073.5 0 XP_011509128 (OMIM: 607505) PREDICTED: PAS domain- (1355) 7573 1073.5 0 NP_055963 (OMIM: 607505) PAS domain-containing ser (1323) 7526 1067.0 0 XP_016859124 (OMIM: 607505) PREDICTED: PAS domain- (1323) 7526 1067.0 0 NP_001239049 (OMIM: 607505) PAS domain-containing (1323) 7526 1067.0 0 XP_016859125 (OMIM: 607505) PREDICTED: PAS domain- (1323) 7526 1067.0 0 XP_016859123 (OMIM: 607505) PREDICTED: PAS domain- (1414) 7526 1067.0 0 XP_011509133 (OMIM: 607505) PREDICTED: PAS domain- (1144) 6234 886.1 0 XP_011509134 (OMIM: 607505) PREDICTED: PAS domain- (1137) 6187 879.5 0 XP_011509135 (OMIM: 607505) PREDICTED: PAS domain- (1114) 6126 871.0 0 XP_005247048 (OMIM: 607505) PREDICTED: PAS domain- (1107) 6079 864.4 0 NP_001239051 (OMIM: 607505) PAS domain-containing (1288) 5630 801.7 0 XP_011509136 (OMIM: 607505) PREDICTED: PAS domain- ( 944) 4652 664.7 7.5e-190 XP_011509137 (OMIM: 607505) PREDICTED: PAS domain- ( 873) 4494 642.5 3.2e-183 NP_003948 (OMIM: 609236) serine/threonine-protein ( 668) 218 44.1 0.0034 NP_001243558 (OMIM: 609236) serine/threonine-prote ( 674) 218 44.1 0.0034 XP_005253275 (OMIM: 609236) PREDICTED: serine/thre ( 720) 218 44.2 0.0035 NP_001243556 (OMIM: 609236) serine/threonine-prote ( 736) 218 44.2 0.0036 XP_006718437 (OMIM: 609236) PREDICTED: serine/thre ( 758) 218 44.2 0.0036 NP_002639 (OMIM: 164960) serine/threonine-protein ( 313) 212 42.9 0.0037 NP_001001852 (OMIM: 610580) serine/threonine-prote ( 326) 212 42.9 0.0038 XP_016874025 (OMIM: 609236) PREDICTED: serine/thre ( 858) 218 44.3 0.0039 XP_016874022 (OMIM: 609236) PREDICTED: serine/thre ( 880) 218 44.3 0.004 NP_115806 (OMIM: 609235) serine/threonine-protein ( 778) 217 44.1 0.0041 NP_001230115 (OMIM: 164960) serine/threonine-prote ( 404) 212 43.0 0.0044 >>NP_001239053 (OMIM: 607505) PAS domain-containing seri (1143 aa) initn: 7738 init1: 7738 opt: 7738 Z-score: 5861.9 bits: 1096.5 E(85289): 0 Smith-Waterman score: 7738; 99.8% identity (99.9% similar) in 1143 aa overlap (1-1143:1-1143) 10 20 30 40 50 60 pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_001 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR 1090 1100 1110 1120 1130 1140 pF1KE2 FSL ::: NP_001 FSL >>XP_011509132 (OMIM: 607505) PREDICTED: PAS domain-cont (1330 aa) initn: 7614 init1: 7570 opt: 7573 Z-score: 5736.4 bits: 1073.5 E(85289): 0 Smith-Waterman score: 7573; 99.4% identity (99.6% similar) in 1124 aa overlap (1-1124:1-1124) 10 20 30 40 50 60 pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: XP_011 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR ::::::::::::::::::::::::::::::::::::::. .: XP_011 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN 1090 1100 1110 1120 1130 1140 pF1KE2 FSL XP_011 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL 1150 1160 1170 1180 1190 1200 >>XP_011509130 (OMIM: 607505) PREDICTED: PAS domain-cont (1330 aa) initn: 7614 init1: 7570 opt: 7573 Z-score: 5736.4 bits: 1073.5 E(85289): 0 Smith-Waterman score: 7573; 99.4% identity (99.6% similar) in 1124 aa overlap (1-1124:1-1124) 10 20 30 40 50 60 pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: XP_011 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR ::::::::::::::::::::::::::::::::::::::. .: XP_011 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN 1090 1100 1110 1120 1130 1140 pF1KE2 FSL XP_011 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL 1150 1160 1170 1180 1190 1200 >>NP_001239048 (OMIM: 607505) PAS domain-containing seri (1330 aa) initn: 7614 init1: 7570 opt: 7573 Z-score: 5736.4 bits: 1073.5 E(85289): 0 Smith-Waterman score: 7573; 99.4% identity (99.6% similar) in 1124 aa overlap (1-1124:1-1124) 10 20 30 40 50 60 pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_001 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR ::::::::::::::::::::::::::::::::::::::. .: NP_001 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN 1090 1100 1110 1120 1130 1140 pF1KE2 FSL NP_001 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL 1150 1160 1170 1180 1190 1200 >>XP_011509131 (OMIM: 607505) PREDICTED: PAS domain-cont (1330 aa) initn: 7614 init1: 7570 opt: 7573 Z-score: 5736.4 bits: 1073.5 E(85289): 0 Smith-Waterman score: 7573; 99.4% identity (99.6% similar) in 1124 aa overlap (1-1124:1-1124) 10 20 30 40 50 60 pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: XP_011 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR ::::::::::::::::::::::::::::::::::::::. .: XP_011 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN 1090 1100 1110 1120 1130 1140 pF1KE2 FSL XP_011 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL 1150 1160 1170 1180 1190 1200 >>XP_011509128 (OMIM: 607505) PREDICTED: PAS domain-cont (1355 aa) initn: 7614 init1: 7570 opt: 7573 Z-score: 5736.3 bits: 1073.5 E(85289): 0 Smith-Waterman score: 7573; 99.4% identity (99.6% similar) in 1124 aa overlap (1-1124:26-1149) 10 20 30 pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTA ::::::::::::::::::::::::::::::::::: XP_011 MRPRAAPPPEQLLELEAWQLASLLPMEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTA 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE2 EPSRSFSSAHRHLSRRNGLSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPSRSFSSAHRHLSRRNGLSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEH 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE2 TDPSEPRGSVSCCSLLRGLSSGWSSPLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDPSEPRGSVSCCSLLRGLSSGWSSPLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE2 GYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSV 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE2 WMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHIT 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE2 DLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGY 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE2 RASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLA 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE2 YNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIR 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE2 KLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALG 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE2 REEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLER 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE2 MGVSGPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGVSGPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAG 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE2 LSFGTPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: XP_011 LSFGTPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVS 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE2 SCDLGGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SCDLGGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQT 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE2 SSNCSCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSNCSCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRE 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE2 SCVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTP :::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::: XP_011 SCVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTP 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE2 VIVMRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIVMRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHS 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE2 QRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEY 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE2 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KE2 LSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAG 1090 1100 1110 1120 1130 1140 1120 1130 1140 pF1KE2 QSRVSVNAGLGAWVRWLQRSVIHTRFSL :::. .: XP_011 QSRLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEY 1150 1160 1170 1180 1190 1200 >>NP_055963 (OMIM: 607505) PAS domain-containing serine/ (1323 aa) initn: 7570 init1: 7526 opt: 7526 Z-score: 5700.9 bits: 1067.0 E(85289): 0 Smith-Waterman score: 7526; 99.7% identity (99.9% similar) in 1112 aa overlap (1-1112:1-1112) 10 20 30 40 50 60 pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_055 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR :::::::::::::::::::::::::::::::. NP_055 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDF 1090 1100 1110 1120 1130 1140 pF1KE2 FSL NP_055 TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEE 1150 1160 1170 1180 1190 1200 >>XP_016859124 (OMIM: 607505) PREDICTED: PAS domain-cont (1323 aa) initn: 7570 init1: 7526 opt: 7526 Z-score: 5700.9 bits: 1067.0 E(85289): 0 Smith-Waterman score: 7526; 99.7% identity (99.9% similar) in 1112 aa overlap (1-1112:1-1112) 10 20 30 40 50 60 pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: XP_016 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR :::::::::::::::::::::::::::::::. XP_016 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDF 1090 1100 1110 1120 1130 1140 pF1KE2 FSL XP_016 TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEE 1150 1160 1170 1180 1190 1200 >>NP_001239049 (OMIM: 607505) PAS domain-containing seri (1323 aa) initn: 7570 init1: 7526 opt: 7526 Z-score: 5700.9 bits: 1067.0 E(85289): 0 Smith-Waterman score: 7526; 99.7% identity (99.9% similar) in 1112 aa overlap (1-1112:1-1112) 10 20 30 40 50 60 pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_001 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR :::::::::::::::::::::::::::::::. NP_001 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDF 1090 1100 1110 1120 1130 1140 pF1KE2 FSL NP_001 TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEE 1150 1160 1170 1180 1190 1200 >>XP_016859125 (OMIM: 607505) PREDICTED: PAS domain-cont (1323 aa) initn: 7570 init1: 7526 opt: 7526 Z-score: 5700.9 bits: 1067.0 E(85289): 0 Smith-Waterman score: 7526; 99.7% identity (99.9% similar) in 1112 aa overlap (1-1112:1-1112) 10 20 30 40 50 60 pF1KE2 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: XP_016 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRVSVNAGLGAWVRWLQRSVIHTR :::::::::::::::::::::::::::::::. XP_016 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDF 1090 1100 1110 1120 1130 1140 pF1KE2 FSL XP_016 TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEE 1150 1160 1170 1180 1190 1200 1143 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 16:41:19 2016 done: Tue Nov 8 16:41:21 2016 Total Scan time: 11.660 Total Display time: 0.420 Function used was FASTA [36.3.4 Apr, 2011]