FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2732, 1608 aa 1>>>pF1KE2732 1608 - 1608 aa - 1608 aa Library: /omim/omim.rfq.tfa 65089639 residues in 91964 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.7006+/-0.000547; mu= -6.9608+/- 0.035 mean_var=693.2315+/-146.196, 0's: 0 Z-trim(121.2): 1492 B-trim: 0 in 0/61 Lambda= 0.048712 statistics sampled from 36846 (38915) to 36846 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.699), E-opt: 0.2 (0.423), width: 16 Scan time: 9.400 The best scores are: opt bits E(91964) NP_005913 (OMIM: 602425) mitogen-activated protein (1608) 10787 775.3 0 NP_001288001 (OMIM: 602425) mitogen-activated prot (1604) 10743 772.3 0 XP_016866358 (OMIM: 602425) mitogen-activated prot (1517) 10126 728.9 8.7e-209 NP_006715 (OMIM: 602425) mitogen-activated protein (1558) 7919 573.8 4.3e-162 NP_001350511 (OMIM: 602425) mitogen-activated prot (1554) 7875 570.7 3.7e-161 NP_001278887 (OMIM: 602425) mitogen-activated prot (1061) 6948 505.3 1.2e-141 NP_001317360 (OMIM: 602539) mitogen-activated prot ( 622) 689 65.2 2.2e-09 NP_001350697 (OMIM: 602539) mitogen-activated prot ( 653) 689 65.2 2.3e-09 NP_002392 (OMIM: 602539) mitogen-activated protein ( 626) 687 65.0 2.4e-09 NP_976226 (OMIM: 602539) mitogen-activated protein ( 657) 687 65.1 2.5e-09 XP_024308320 (OMIM: 609487) mitogen-activated prot ( 619) 670 63.8 5.6e-09 NP_006600 (OMIM: 609487) mitogen-activated protein ( 619) 670 63.8 5.6e-09 XP_016864974 (OMIM: 600982,613762) mitogen-activat (1349) 580 57.9 7.2e-07 XP_016864973 (OMIM: 600982,613762) mitogen-activat (1375) 580 57.9 7.3e-07 NP_005912 (OMIM: 600982,613762) mitogen-activated (1512) 580 58.0 7.7e-07 XP_011543813 (OMIM: 300820) mitogen-activated prot ( 748) 565 56.6 1e-06 XP_011543812 (OMIM: 300820) mitogen-activated prot ( 871) 565 56.6 1.1e-06 XP_016866366 (OMIM: 602448) mitogen-activated prot (1181) 568 57.0 1.2e-06 XP_016866365 (OMIM: 602448) mitogen-activated prot (1191) 568 57.0 1.2e-06 XP_011534141 (OMIM: 602448) mitogen-activated prot (1286) 568 57.1 1.3e-06 NP_005914 (OMIM: 602448) mitogen-activated protein (1374) 568 57.1 1.3e-06 XP_016866364 (OMIM: 602448) mitogen-activated prot (1447) 568 57.1 1.4e-06 XP_016866363 (OMIM: 602448) mitogen-activated prot (1458) 568 57.1 1.4e-06 XP_011543810 (OMIM: 300820) mitogen-activated prot (1169) 565 56.8 1.4e-06 XP_016866362 (OMIM: 602448) mitogen-activated prot (1483) 568 57.1 1.4e-06 XP_016866361 (OMIM: 602448) mitogen-activated prot (1484) 568 57.1 1.4e-06 XP_016866360 (OMIM: 602448) mitogen-activated prot (1493) 568 57.2 1.4e-06 XP_016866359 (OMIM: 602448) mitogen-activated prot (1494) 568 57.2 1.4e-06 XP_011543809 (OMIM: 300820) mitogen-activated prot (1198) 565 56.8 1.4e-06 XP_016858260 (OMIM: 604468) mitogen-activated prot ( 869) 560 56.3 1.5e-06 NP_001001671 (OMIM: 300820) mitogen-activated prot (1313) 565 56.9 1.5e-06 NP_001284538 (OMIM: 604468) mitogen-activated prot (1280) 560 56.5 1.9e-06 NP_004663 (OMIM: 604468) mitogen-activated protein (1288) 560 56.5 1.9e-06 XP_011538703 (OMIM: 616563) STE20-like serine/thre ( 783) 531 54.2 5.6e-06 XP_024304332 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06 XP_016873336 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06 XP_016873338 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06 XP_016873339 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06 XP_024304330 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06 XP_016873337 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06 NP_002567 (OMIM: 602590) serine/threonine-protein ( 545) 525 53.6 6e-06 XP_024304329 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06 XP_024304328 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06 XP_016873335 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06 XP_024304331 (OMIM: 602590) serine/threonine-prote ( 545) 525 53.6 6e-06 XP_016861990 (OMIM: 605022) serine/threonine-prote ( 524) 524 53.5 6.2e-06 NP_002568 (OMIM: 605022) serine/threonine-protein ( 524) 524 53.5 6.2e-06 XP_011511172 (OMIM: 605022) serine/threonine-prote ( 524) 524 53.5 6.2e-06 NP_001311261 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.5 6.3e-06 NP_001311263 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.5 6.3e-06 >>NP_005913 (OMIM: 602425) mitogen-activated protein kin (1608 aa) initn: 10787 init1: 10787 opt: 10787 Z-score: 4120.7 bits: 775.3 E(91964): 0 Smith-Waterman score: 10787; 100.0% identity (100.0% similar) in 1608 aa overlap (1-1608:1-1608) 10 20 30 40 50 60 pF1KE2 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE2 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE2 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE2 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE2 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KE2 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KE2 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 pF1KE2 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE :::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1570 1580 1590 1600 >>NP_001288001 (OMIM: 602425) mitogen-activated protein (1604 aa) initn: 7624 init1: 7624 opt: 10743 Z-score: 4104.0 bits: 772.3 E(91964): 0 Smith-Waterman score: 10743; 99.8% identity (99.8% similar) in 1608 aa overlap (1-1608:1-1604) 10 20 30 40 50 60 pF1KE2 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVT-- 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KE2 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 --AIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KE2 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP 1200 1210 1220 1230 1240 1250 1270 1280 1290 1300 1310 1320 pF1KE2 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ 1260 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 1380 pF1KE2 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND 1320 1330 1340 1350 1360 1370 1390 1400 1410 1420 1430 1440 pF1KE2 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI 1380 1390 1400 1410 1420 1430 1450 1460 1470 1480 1490 1500 pF1KE2 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN 1440 1450 1460 1470 1480 1490 1510 1520 1530 1540 1550 1560 pF1KE2 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM 1500 1510 1520 1530 1540 1550 1570 1580 1590 1600 pF1KE2 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1560 1570 1580 1590 1600 >>XP_016866358 (OMIM: 602425) mitogen-activated protein (1517 aa) initn: 10126 init1: 10126 opt: 10126 Z-score: 3869.9 bits: 728.9 E(91964): 8.7e-209 Smith-Waterman score: 10126; 99.9% identity (100.0% similar) in 1517 aa overlap (92-1608:1-1517) 70 80 90 100 110 120 pF1KE2 KSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAPN :::::::::::::::::::::::::::::: XP_016 MKRMSTKHQRNNVGRPASRSNLKEKMNAPN 10 20 30 130 140 150 160 170 180 pF1KE2 QPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIPD :::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::: XP_016 QPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIPD 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE2 VDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKK 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE2 KDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTF 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE2 KVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELL 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE2 EYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSD 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE2 IGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDNS 340 350 360 370 380 390 490 500 510 520 530 540 pF1KE2 FDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRK 400 410 420 430 440 450 550 560 570 580 590 600 pF1KE2 LILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSW 460 470 480 490 500 510 610 620 630 640 650 660 pF1KE2 EELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKG 520 530 540 550 560 570 670 680 690 700 710 720 pF1KE2 GLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHS 580 590 600 610 620 630 730 740 750 760 770 780 pF1KE2 LKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSA 640 650 660 670 680 690 790 800 810 820 830 840 pF1KE2 DDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDL 700 710 720 730 740 750 850 860 870 880 890 900 pF1KE2 LDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYL 760 770 780 790 800 810 910 920 930 940 950 960 pF1KE2 LLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKA 820 830 840 850 860 870 970 980 990 1000 1010 1020 pF1KE2 FQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVD 880 890 900 910 920 930 1030 1040 1050 1060 1070 1080 pF1KE2 ESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKC 940 950 960 970 980 990 1090 1100 1110 1120 1130 1140 pF1KE2 ESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLY 1000 1010 1020 1030 1040 1050 1150 1160 1170 1180 1190 1200 pF1KE2 LAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVA 1060 1070 1080 1090 1100 1110 1210 1220 1230 1240 1250 1260 pF1KE2 ASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA 1120 1130 1140 1150 1160 1170 1270 1280 1290 1300 1310 1320 pF1KE2 YPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQV 1180 1190 1200 1210 1220 1230 1330 1340 1350 1360 1370 1380 pF1KE2 CDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDH 1240 1250 1260 1270 1280 1290 1390 1400 1410 1420 1430 1440 pF1KE2 KTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIR 1300 1310 1320 1330 1340 1350 1450 1460 1470 1480 1490 1500 pF1KE2 LYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNS 1360 1370 1380 1390 1400 1410 1510 1520 1530 1540 1550 1560 pF1KE2 TLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMG 1420 1430 1440 1450 1460 1470 1570 1580 1590 1600 pF1KE2 HKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1480 1490 1500 1510 >>NP_006715 (OMIM: 602425) mitogen-activated protein kin (1558 aa) initn: 7910 init1: 7910 opt: 7919 Z-score: 3031.6 bits: 573.8 E(91964): 4.3e-162 Smith-Waterman score: 10365; 96.9% identity (96.9% similar) in 1608 aa overlap (1-1608:1-1558) 10 20 30 40 50 60 pF1KE2 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV :::::::::::::::::::::::::::::::::: NP_006 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGF-------------------------- 1150 1160 1170 1210 1220 1230 1240 1250 1260 pF1KE2 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP :::::::::::::::::::::::::::::::::::: NP_006 ------------------------RGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP 1180 1190 1200 1210 1270 1280 1290 1300 1310 1320 pF1KE2 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ 1220 1230 1240 1250 1260 1270 1330 1340 1350 1360 1370 1380 pF1KE2 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND 1280 1290 1300 1310 1320 1330 1390 1400 1410 1420 1430 1440 pF1KE2 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI 1340 1350 1360 1370 1380 1390 1450 1460 1470 1480 1490 1500 pF1KE2 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN 1400 1410 1420 1430 1440 1450 1510 1520 1530 1540 1550 1560 pF1KE2 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM 1460 1470 1480 1490 1500 1510 1570 1580 1590 1600 pF1KE2 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE :::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1520 1530 1540 1550 >>NP_001350511 (OMIM: 602425) mitogen-activated protein (1554 aa) initn: 10573 init1: 7624 opt: 7875 Z-score: 3014.9 bits: 570.7 E(91964): 3.7e-161 Smith-Waterman score: 10321; 96.6% identity (96.6% similar) in 1608 aa overlap (1-1608:1-1554) 10 20 30 40 50 60 pF1KE2 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVT-- 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KE2 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV :::::::::::::::::::::::::::::::: NP_001 --AIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGF-------------------------- 1140 1150 1160 1170 1210 1220 1230 1240 1250 1260 pF1KE2 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP :::::::::::::::::::::::::::::::::::: NP_001 ------------------------RGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP 1180 1190 1200 1270 1280 1290 1300 1310 1320 pF1KE2 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ 1210 1220 1230 1240 1250 1260 1330 1340 1350 1360 1370 1380 pF1KE2 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND 1270 1280 1290 1300 1310 1320 1390 1400 1410 1420 1430 1440 pF1KE2 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI 1330 1340 1350 1360 1370 1380 1450 1460 1470 1480 1490 1500 pF1KE2 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN 1390 1400 1410 1420 1430 1440 1510 1520 1530 1540 1550 1560 pF1KE2 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM 1450 1460 1470 1480 1490 1500 1570 1580 1590 1600 pF1KE2 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1510 1520 1530 1540 1550 >>NP_001278887 (OMIM: 602425) mitogen-activated protein (1061 aa) initn: 6939 init1: 6939 opt: 6948 Z-score: 2664.6 bits: 505.3 E(91964): 1.2e-141 Smith-Waterman score: 6948; 98.6% identity (99.1% similar) in 1058 aa overlap (552-1608:4-1061) 530 540 550 560 570 580 pF1KE2 LTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKNDR-PVEFSEFPDPMWGS ::.:. : . .. .::::::::::: NP_001 MYIGSIQKDRTTRSRDGACRSQFSEFPDPMWGS 10 20 30 590 600 610 620 630 640 pF1KE2 DYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPA 40 50 60 70 80 90 650 660 670 680 690 700 pF1KE2 GEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMV 100 110 120 130 140 150 710 720 730 740 750 760 pF1KE2 YFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLK 160 170 180 190 200 210 770 780 790 800 810 820 pF1KE2 STGSFLEFGLQESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STGSFLEFGLQESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAK 220 230 240 250 260 270 830 840 850 860 870 880 pF1KE2 MLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLL 280 290 300 310 320 330 890 900 910 920 930 940 pF1KE2 NAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSM 340 350 360 370 380 390 950 960 970 980 990 1000 pF1KE2 QVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNR 400 410 420 430 440 450 1010 1020 1030 1040 1050 1060 pF1KE2 ISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQ 460 470 480 490 500 510 1070 1080 1090 1100 1110 1120 pF1KE2 KIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQA 520 530 540 550 560 570 1130 1140 1150 1160 1170 1180 pF1KE2 LMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMP 580 590 600 610 620 630 1190 1200 1210 1220 1230 1240 pF1KE2 SDARSHGSPAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDARSHGSPAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAA 640 650 660 670 680 690 1250 1260 1270 1280 1290 1300 pF1KE2 ELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKS 700 710 720 730 740 750 1310 1320 1330 1340 1350 1360 pF1KE2 VRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTC 760 770 780 790 800 810 1370 1380 1390 1400 1410 1420 pF1KE2 ISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFME 820 830 840 850 860 870 1430 1440 1450 1460 1470 1480 pF1KE2 YCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLG 880 890 900 910 920 930 1490 1500 1510 1520 1530 1540 pF1KE2 DFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVT 940 950 960 970 980 990 1550 1560 1570 1580 1590 1600 pF1KE2 GKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSF 1000 1010 1020 1030 1040 1050 pF1KE2 VKVCTDEE :::::::: NP_001 VKVCTDEE 1060 >>NP_001317360 (OMIM: 602539) mitogen-activated protein (622 aa) initn: 527 init1: 216 opt: 689 Z-score: 290.0 bits: 65.2 E(91964): 2.2e-09 Smith-Waterman score: 690; 29.0% identity (59.0% similar) in 507 aa overlap (1121-1603:120-620) 1100 1110 1120 1130 1140 1150 pF1KE2 WATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPR :... .: ..::: :. .: NP_001 LSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG 90 100 110 120 130 140 1160 1170 1180 1190 1200 1210 pF1KE2 PMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVAASRPSPSGG ... .: . :: . . . . :. . . . : .. .. . .. : . NP_001 DINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS 150 160 170 180 190 200 1220 1230 1240 1250 1260 pF1KE2 DSVLPKSISSAHDTRGSSVPENDRLASIAAEL-QFRSLSRHSSPTEERDEPAYPRGDSSG .. . .:::... ..: : . ... . .:. . . .:. : .: ..: NP_001 EQCMLDPLSSAENSLSGSCQSLDSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGG 210 220 230 240 250 260 1270 1280 1290 1300 1310 1320 pF1KE2 STRRSWELRTLISQSKDTASKLGPIEAIQKSV-RLFEEKRYREMRRKNI--IGQVCDTPK . : ... . .. .: . :. : .. : .: .:. : : :. NP_001 TYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLD-PR 270 280 290 300 310 320 1330 1340 1350 1360 1370 pF1KE2 SY------DNVMHVGLRKVTFK-------WQRGNKIGEGQYGKVYTCISVDTGELMAMKE . .:.. : :.: : :.::. .:.: .:.:: : .::::. .: :. NP_001 GRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQ 330 340 350 360 370 380 1380 1390 1400 1410 1420 pF1KE2 IRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVELHREE--MYIFMEYCDEGTL- ..:.:.. .: ::.. :........: .:.:.: : : . ::::: :.. NP_001 VQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVK 390 400 410 420 430 440 1430 1440 1450 1460 1470 1480 pF1KE2 EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSV .... : : : : : :..:: ... :: . :::::::::::. :.: .:::::: : NP_001 DQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK 450 460 470 480 490 500 1490 1500 1510 1520 1530 1540 pF1KE2 KLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWH .:.. .. : . :. :: .:.::::. :::.:: ::.:::::.:.::.: : :: NP_001 RLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKADVWSLGCTVVEMLTEKPPWA 510 520 530 540 550 560 1550 1560 1570 1580 1590 1600 pF1KE2 EYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTD ::: :. . . .: .: ..: .:.::: . . . ..: .: .:: : :... NP_001 EYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELLTHHFAQLMY 570 580 590 600 610 620 pF1KE2 EE >>NP_001350697 (OMIM: 602539) mitogen-activated protein (653 aa) initn: 527 init1: 216 opt: 689 Z-score: 289.8 bits: 65.2 E(91964): 2.3e-09 Smith-Waterman score: 690; 29.0% identity (59.0% similar) in 507 aa overlap (1121-1603:151-651) 1100 1110 1120 1130 1140 1150 pF1KE2 WATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPR :... .: ..::: :. .: NP_001 LSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG 130 140 150 160 170 180 1160 1170 1180 1190 1200 1210 pF1KE2 PMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVAASRPSPSGG ... .: . :: . . . . :. . . . : .. .. . .. : . NP_001 DINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS 190 200 210 220 230 240 1220 1230 1240 1250 1260 pF1KE2 DSVLPKSISSAHDTRGSSVPENDRLASIAAEL-QFRSLSRHSSPTEERDEPAYPRGDSSG .. . .:::... ..: : . ... . .:. . . .:. : .: ..: NP_001 EQCMLDPLSSAENSLSGSCQSLDSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGG 250 260 270 280 290 300 1270 1280 1290 1300 1310 1320 pF1KE2 STRRSWELRTLISQSKDTASKLGPIEAIQKSV-RLFEEKRYREMRRKNI--IGQVCDTPK . : ... . .. .: . :. : .. : .: .:. : : :. NP_001 TYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLD-PR 310 320 330 340 350 1330 1340 1350 1360 1370 pF1KE2 SY------DNVMHVGLRKVTFK-------WQRGNKIGEGQYGKVYTCISVDTGELMAMKE . .:.. : :.: : :.::. .:.: .:.:: : .::::. .: :. NP_001 GRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQ 360 370 380 390 400 410 1380 1390 1400 1410 1420 pF1KE2 IRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVELHREE--MYIFMEYCDEGTL- ..:.:.. .: ::.. :........: .:.:.: : : . ::::: :.. NP_001 VQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVK 420 430 440 450 460 470 1430 1440 1450 1460 1470 1480 pF1KE2 EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSV .... : : : : : :..:: ... :: . :::::::::::. :.: .:::::: : NP_001 DQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK 480 490 500 510 520 530 1490 1500 1510 1520 1530 1540 pF1KE2 KLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWH .:.. .. : . :. :: .:.::::. :::.:: ::.:::::.:.::.: : :: NP_001 RLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKADVWSLGCTVVEMLTEKPPWA 540 550 560 570 580 590 1550 1560 1570 1580 1590 1600 pF1KE2 EYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTD ::: :. . . .: .: ..: .:.::: . . . ..: .: .:: : :... NP_001 EYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELLTHHFAQLMY 600 610 620 630 640 650 pF1KE2 EE >>NP_002392 (OMIM: 602539) mitogen-activated protein kin (626 aa) initn: 561 init1: 216 opt: 687 Z-score: 289.2 bits: 65.0 E(91964): 2.4e-09 Smith-Waterman score: 703; 29.9% identity (59.2% similar) in 512 aa overlap (1121-1603:120-624) 1100 1110 1120 1130 1140 1150 pF1KE2 WATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPR :... .: ..::: :. .: NP_002 LSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG 90 100 110 120 130 140 1160 1170 1180 1190 1200 1210 pF1KE2 PMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVAASRPSPSGG ... .: . :: . . . . :. . . . : .. .. . .. : . NP_002 DINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS 150 160 170 180 190 200 1220 1230 1240 1250 1260 pF1KE2 DSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA------YPR .. . .:::... ..: :: :. . . : .:: .: ..:.: . : . NP_002 EQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSR-MSRAQSFPDNRQEYSDRETQLYDK 210 220 230 240 250 260 1270 1280 1290 1300 1310 1320 pF1KE2 GDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSV-RLFEEKRYREMRRKNI--IGQV : ..:. : ... . .. .: . :. : .. : .: .:. : NP_002 GVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQY 270 280 290 300 310 320 1330 1340 1350 1360 pF1KE2 CDTPKSY------DNVMHVGLRKVTFK-------WQRGNKIGEGQYGKVYTCISVDTGEL : :.. .:.. : :.: : :.::. .:.: .:.:: : .::::. NP_002 LD-PRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRE 330 340 350 360 370 380 1370 1380 1390 1400 1410 1420 pF1KE2 MAMKEIRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVELHREE--MYIFMEYCD .: :...:.:.. .: ::.. :........: .:.:.: : : . ::::: NP_002 LASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMP 390 400 410 420 430 440 1430 1440 1450 1460 1470 1480 pF1KE2 EGTL-EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGD :.. .... : : : : : :..:: ... :: . :::::::::::. :.: .:::: NP_002 GGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGD 450 460 470 480 490 500 1490 1500 1510 1520 1530 1540 pF1KE2 FGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTG :: : .:.. .. : . :. :: .:.::::. :::.:: ::.:::::.:.::.: NP_002 FGASKRLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKADVWSLGCTVVEMLTE 510 520 530 540 550 560 1550 1560 1570 1580 1590 1600 pF1KE2 KRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV : :: ::: :. . . .: .: ..: .:.::: . . . ..: .: .:: : :. NP_002 KPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELLTHHFA 570 580 590 600 610 620 pF1KE2 KVCTDEE .. NP_002 QLMY >>NP_976226 (OMIM: 602539) mitogen-activated protein kin (657 aa) initn: 561 init1: 216 opt: 687 Z-score: 289.0 bits: 65.1 E(91964): 2.5e-09 Smith-Waterman score: 703; 29.9% identity (59.2% similar) in 512 aa overlap (1121-1603:151-655) 1100 1110 1120 1130 1140 1150 pF1KE2 WATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPR :... .: ..::: :. .: NP_976 LSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG 130 140 150 160 170 180 1160 1170 1180 1190 1200 1210 pF1KE2 PMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVAASRPSPSGG ... .: . :: . . . . :. . . . : .. .. . .. : . NP_976 DINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS 190 200 210 220 230 240 1220 1230 1240 1250 1260 pF1KE2 DSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA------YPR .. . .:::... ..: :: :. . . : .:: .: ..:.: . : . NP_976 EQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSR-MSRAQSFPDNRQEYSDRETQLYDK 250 260 270 280 290 1270 1280 1290 1300 1310 1320 pF1KE2 GDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSV-RLFEEKRYREMRRKNI--IGQV : ..:. : ... . .. .: . :. : .. : .: .:. : NP_976 GVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQY 300 310 320 330 340 350 1330 1340 1350 1360 pF1KE2 CDTPKSY------DNVMHVGLRKVTFK-------WQRGNKIGEGQYGKVYTCISVDTGEL : :.. .:.. : :.: : :.::. .:.: .:.:: : .::::. NP_976 LD-PRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRE 360 370 380 390 400 410 1370 1380 1390 1400 1410 1420 pF1KE2 MAMKEIRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVELHREE--MYIFMEYCD .: :...:.:.. .: ::.. :........: .:.:.: : : . ::::: NP_976 LASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMP 420 430 440 450 460 470 1430 1440 1450 1460 1470 1480 pF1KE2 EGTL-EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGD :.. .... : : : : : :..:: ... :: . :::::::::::. :.: .:::: NP_976 GGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGD 480 490 500 510 520 530 1490 1500 1510 1520 1530 1540 pF1KE2 FGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTG :: : .:.. .. : . :. :: .:.::::. :::.:: ::.:::::.:.::.: NP_976 FGASKRLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKADVWSLGCTVVEMLTE 540 550 560 570 580 590 1550 1560 1570 1580 1590 1600 pF1KE2 KRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV : :: ::: :. . . .: .: ..: .:.::: . . . ..: .: .:: : :. NP_976 KPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELLTHHFA 600 610 620 630 640 650 pF1KE2 KVCTDEE .. NP_976 QLMY 1608 residues in 1 query sequences 65089639 residues in 91964 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Oct 2 18:32:26 2018 done: Tue Oct 2 18:32:27 2018 Total Scan time: 9.400 Total Display time: 0.420 Function used was FASTA [36.3.4 Apr, 2011]