FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2697, 632 aa 1>>>pF1KE2697 632 - 632 aa - 632 aa Library: /omim/omim.rfq.tfa 62035967 residues in 87258 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1531+/-0.000385; mu= 12.0752+/- 0.024 mean_var=159.5661+/-31.912, 0's: 0 Z-trim(117.2): 23 B-trim: 104 in 1/54 Lambda= 0.101532 statistics sampled from 29347 (29370) to 29347 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.675), E-opt: 0.2 (0.337), width: 16 Scan time: 5.920 The best scores are: opt bits E(87258) NP_002015 (OMIM: 300623,300624,309550,311360) syna ( 632) 4220 630.6 5.1e-180 NP_001172004 (OMIM: 300623,300624,309550,311360) s ( 537) 2801 422.7 1.7e-117 NP_001172011 (OMIM: 300623,300624,309550,311360) s ( 586) 2507 379.7 1.6e-104 NP_001172010 (OMIM: 300623,300624,309550,311360) s ( 516) 2487 376.7 1.1e-103 NP_001172005 (OMIM: 300623,300624,309550,311360) s ( 611) 2487 376.8 1.3e-103 NP_001013456 (OMIM: 600819) fragile X mental retar ( 539) 1670 257.0 1.2e-67 XP_005247873 (OMIM: 600819) PREDICTED: fragile X m ( 568) 1670 257.1 1.3e-67 NP_005078 (OMIM: 600819) fragile X mental retardat ( 621) 1670 257.1 1.4e-67 XP_005247872 (OMIM: 600819) PREDICTED: fragile X m ( 648) 1670 257.1 1.4e-67 XP_005247871 (OMIM: 600819) PREDICTED: fragile X m ( 650) 1670 257.1 1.4e-67 XP_005247870 (OMIM: 600819) PREDICTED: fragile X m ( 677) 1670 257.1 1.5e-67 NP_004851 (OMIM: 605339) fragile X mental retardat ( 673) 1604 247.5 1.2e-64 XP_016862790 (OMIM: 600819) PREDICTED: fragile X m ( 454) 1194 187.3 1.1e-46 XP_016862789 (OMIM: 600819) PREDICTED: fragile X m ( 483) 1194 187.3 1.1e-46 NP_001013457 (OMIM: 600819) fragile X mental retar ( 536) 1194 187.3 1.2e-46 XP_016862788 (OMIM: 600819) PREDICTED: fragile X m ( 563) 1194 187.3 1.3e-46 XP_016862787 (OMIM: 600819) PREDICTED: fragile X m ( 565) 1194 187.3 1.3e-46 XP_006713838 (OMIM: 600819) PREDICTED: fragile X m ( 592) 1194 187.4 1.3e-46 >>NP_002015 (OMIM: 300623,300624,309550,311360) synaptic (632 aa) initn: 4220 init1: 4220 opt: 4220 Z-score: 3353.1 bits: 630.6 E(87258): 5.1e-180 Smith-Waterman score: 4220; 100.0% identity (100.0% similar) in 632 aa overlap (1-632:1-632) 10 20 30 40 50 60 pF1KE2 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 NSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 LNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 HGRRGPGYTSGTNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 HGRRGPGYTSGTNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGGRG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QGGRGRGGGFKGNDDHSRTDNRPRNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQNTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QGGRGRGGGFKGNDDHSRTDNRPRNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQNTSS 550 560 570 580 590 600 610 620 630 pF1KE2 EGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP :::::::::::::::::::::::::::::::: NP_002 EGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP 610 620 630 >>NP_001172004 (OMIM: 300623,300624,309550,311360) synap (537 aa) initn: 2826 init1: 2801 opt: 2801 Z-score: 2230.7 bits: 422.7 E(87258): 1.7e-117 Smith-Waterman score: 2801; 100.0% identity (100.0% similar) in 425 aa overlap (1-425:1-425) 10 20 30 40 50 60 pF1KE2 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 NSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 LNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRG ::::: NP_001 LNYLKLQQRKRGRASCAEETDGGVEGEEEDKEEEDVEEASKETTITPEQIIVHVIQERLK 430 440 450 460 470 480 >>NP_001172011 (OMIM: 300623,300624,309550,311360) synap (586 aa) initn: 3299 init1: 2487 opt: 2507 Z-score: 1997.5 bits: 379.7 E(87258): 1.6e-104 Smith-Waterman score: 3815; 92.7% identity (92.7% similar) in 632 aa overlap (1-632:1-586) 10 20 30 40 50 60 pF1KE2 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 NSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYH ::::::::::::::: :::::::::::::::::::::::: NP_001 NSTHFSQPNSTKVQR---------------------GMVPFVFVGTKDSIANATVLLDYH 370 380 390 430 440 450 460 470 480 pF1KE2 LNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRG 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE2 HGRRGPGYTSGTNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGGRG :::::::::: ::::::::::::::::::::::::: NP_001 HGRRGPGYTS-------------------------APTEEERESFLRRGDGRRRGGGGRG 460 470 480 490 550 560 570 580 590 600 pF1KE2 QGGRGRGGGFKGNDDHSRTDNRPRNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQNTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGGRGRGGGFKGNDDHSRTDNRPRNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQNTSS 500 510 520 530 540 550 610 620 630 pF1KE2 EGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP :::::::::::::::::::::::::::::::: NP_001 EGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP 560 570 580 >>NP_001172010 (OMIM: 300623,300624,309550,311360) synap (516 aa) initn: 2537 init1: 2487 opt: 2487 Z-score: 1982.4 bits: 376.7 E(87258): 1.1e-103 Smith-Waterman score: 2618; 95.1% identity (95.1% similar) in 425 aa overlap (1-425:1-404) 10 20 30 40 50 60 pF1KE2 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 NSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYH ::::::::::::::: :::::::::::::::::::::::: NP_001 NSTHFSQPNSTKVQR---------------------GMVPFVFVGTKDSIANATVLLDYH 370 380 390 430 440 450 460 470 480 pF1KE2 LNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRG ::::: NP_001 LNYLKLQQRKRGRASCAEETDGGVEGEEEDKEEEDVEEASKETTITPEQIIVHVIQERLK 400 410 420 430 440 450 >>NP_001172005 (OMIM: 300623,300624,309550,311360) synap (611 aa) initn: 2605 init1: 2487 opt: 2487 Z-score: 1981.4 bits: 376.8 E(87258): 1.3e-103 Smith-Waterman score: 4037; 96.7% identity (96.7% similar) in 632 aa overlap (1-632:1-611) 10 20 30 40 50 60 pF1KE2 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 NSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYH ::::::::::::::: :::::::::::::::::::::::: NP_001 NSTHFSQPNSTKVQR---------------------GMVPFVFVGTKDSIANATVLLDYH 370 380 390 430 440 450 460 470 480 pF1KE2 LNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRG 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE2 HGRRGPGYTSGTNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGRRGPGYTSGTNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGGRG 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE2 QGGRGRGGGFKGNDDHSRTDNRPRNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQNTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGGRGRGGGFKGNDDHSRTDNRPRNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQNTSS 520 530 540 550 560 570 610 620 630 pF1KE2 EGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP :::::::::::::::::::::::::::::::: NP_001 EGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP 580 590 600 610 >>NP_001013456 (OMIM: 600819) fragile X mental retardati (539 aa) initn: 2142 init1: 1670 opt: 1670 Z-score: 1335.4 bits: 257.0 E(87258): 1.2e-67 Smith-Waterman score: 2036; 57.2% identity (71.7% similar) in 614 aa overlap (1-610:1-514) 10 20 30 40 50 60 pF1KE2 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN : ::.::::::::::::.:.:::::::.::.:::::::.::.::..::.::: .:.:. NP_001 MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEIS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP :.::::::::::..::: ::::::::.:::::::::::::::::::::.:::: :: :: NP_001 EGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR . :.:: : .:::::::. ::.: ::::::::::: . : ::. ::.::: .:.: :: NP_001 VKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN ...: :::.::.:::: :. :::::.:.:: ..:::. :::.:.::::::::::::::.: NP_001 VNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN :::::::::::::.::::: ::.::::. :::::::.::::.:: ::::::::::::::: NP_001 IQQARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE ::.::::::::::::::::..::...:.:. NP_001 GKVIQEIVDKSGVVRVRIEGDNENKLPRED------------------------------ 310 320 330 370 380 390 400 410 420 pF1KE2 NSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYH :::::::::::.::.:. :::.:: NP_001 ------------------------------------GMVPFVFVGTKESIGNVQVLLEYH 340 350 430 440 450 460 470 480 pF1KE2 LNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRG . :::::.:::.::::::::::::: :: : .:: NP_001 IAYLKEVEQLRMERLQIDEQLRQIG---------------------------SRSYSGRG 360 370 380 490 500 510 520 530 pF1KE2 HGRRGPGYTSG--TNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGG .:::::.:::: :::: :: :::::...::::::::: :..:.: .: . :: :: : NP_001 RGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAG-EDDRDSRHQRDSRRRPGGRG 390 400 410 420 430 440 540 550 560 570 580 590 pF1KE2 RG-QGGRGRGGGFKGNDDHSRTDNRP-RNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQ :. .::::::: :... : . . : :: : . . .: . .: :. NP_001 RSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQT---ADTDASESHHS---T 450 460 470 480 490 500 600 610 620 630 pF1KE2 NTSSEGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP : .. : :: .: NP_001 NRRRRSRRRRTDEDAVLMDGMTESDTASVNENGLGKRCD 510 520 530 >>XP_005247873 (OMIM: 600819) PREDICTED: fragile X menta (568 aa) initn: 1885 init1: 1670 opt: 1670 Z-score: 1335.1 bits: 257.1 E(87258): 1.3e-67 Smith-Waterman score: 2138; 58.6% identity (74.5% similar) in 616 aa overlap (1-610:1-543) 10 20 30 40 50 60 pF1KE2 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN : ::.::::::::::::.:.:::::::.::.:::::::.::.::..::.::: .:.:. XP_005 MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEIS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP :.::::::::::..::: ::::::::.:::::::::::::::::::::.:::: :: :: XP_005 EGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR . :.:: : .:::::::. ::.: ::::::::::: . : ::. ::.::: .:.: :: XP_005 VKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN ...: :::.::.:::: :. :::::.:.:: ..:::. :::.:.::::::::::::::.: XP_005 VNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN :::::::::::::.::::: ::.::::. :::::::.::::.:: ::::::::::::::: XP_005 IQQARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE ::.::::::::::::::::..::...:.:. XP_005 GKVIQEIVDKSGVVRVRIEGDNENKLPRED------------------------------ 310 320 330 370 380 390 400 410 420 pF1KE2 NSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYH :::::::::::.::.:. :::.:: XP_005 ------------------------------------GMVPFVFVGTKESIGNVQVLLEYH 340 350 430 440 450 460 470 pF1KE2 LNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNR-TDKEKSYVTDDGQGMG-RGSRPYRN . :::::.:::.::::::::::::: . :: .: .:::.:.::.. . .::: : . XP_005 IAYLKEVEQLRMERLQIDEQLRQIGMGFRPSSTRGPEKEKGYATDESTVSSVQGSRSYSG 360 370 380 390 400 410 480 490 500 510 520 530 pF1KE2 RGHGRRGPGYTSG--TNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGG ::.:::::.:::: :::: :: :::::...::::::::: :..:.: .: . :: :: XP_005 RGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAG-EDDRDSRHQRDSRRRPGG 420 430 440 450 460 470 540 550 560 570 580 590 pF1KE2 GGRG-QGGRGRGGGFKGNDDHSRTDNRP-RNPREAKGRTTDGSLQIRVDCNNERSVHTKT ::. .::::::: :... : . . : :: : . . .: . .: :. XP_005 RGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQ---TADTDASESHHS-- 480 490 500 510 520 600 610 620 630 pF1KE2 LQNTSSEGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP : .. : :: .: XP_005 -TNRRRRSRRRRTDEDAVLMDGMTESDTASVNENGLGKRCD 530 540 550 560 >>NP_005078 (OMIM: 600819) fragile X mental retardation (621 aa) initn: 2142 init1: 1670 opt: 1670 Z-score: 1334.6 bits: 257.1 E(87258): 1.4e-67 Smith-Waterman score: 2036; 57.2% identity (71.7% similar) in 614 aa overlap (1-610:1-514) 10 20 30 40 50 60 pF1KE2 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN : ::.::::::::::::.:.:::::::.::.:::::::.::.::..::.::: .:.:. NP_005 MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEIS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP :.::::::::::..::: ::::::::.:::::::::::::::::::::.:::: :: :: NP_005 EGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR . :.:: : .:::::::. ::.: ::::::::::: . : ::. ::.::: .:.: :: NP_005 VKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN ...: :::.::.:::: :. :::::.:.:: ..:::. :::.:.::::::::::::::.: NP_005 VNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN :::::::::::::.::::: ::.::::. :::::::.::::.:: ::::::::::::::: NP_005 IQQARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE ::.::::::::::::::::..::...:.:. NP_005 GKVIQEIVDKSGVVRVRIEGDNENKLPRED------------------------------ 310 320 330 370 380 390 400 410 420 pF1KE2 NSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYH :::::::::::.::.:. :::.:: NP_005 ------------------------------------GMVPFVFVGTKESIGNVQVLLEYH 340 350 430 440 450 460 470 480 pF1KE2 LNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRG . :::::.:::.::::::::::::: :: : .:: NP_005 IAYLKEVEQLRMERLQIDEQLRQIG---------------------------SRSYSGRG 360 370 380 490 500 510 520 530 pF1KE2 HGRRGPGYTSG--TNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGG .:::::.:::: :::: :: :::::...::::::::: :..:.: .: . :: :: : NP_005 RGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAG-EDDRDSRHQRDSRRRPGGRG 390 400 410 420 430 440 540 550 560 570 580 590 pF1KE2 RG-QGGRGRGGGFKGNDDHSRTDNRP-RNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQ :. .::::::: :... : . . : :: : . . .: . .: :. NP_005 RSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQT---ADTDASESHHS---T 450 460 470 480 490 500 600 610 620 630 pF1KE2 NTSSEGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP : .. : :: .: NP_005 NRRRRSRRRRTDEDAVLMDGMTESDTASVNENGLVTVADYISRAESQSRQRNLPRETLAK 510 520 530 540 550 560 >>XP_005247872 (OMIM: 600819) PREDICTED: fragile X menta (648 aa) initn: 2142 init1: 1670 opt: 1670 Z-score: 1334.3 bits: 257.1 E(87258): 1.4e-67 Smith-Waterman score: 2036; 57.2% identity (71.7% similar) in 614 aa overlap (1-610:1-514) 10 20 30 40 50 60 pF1KE2 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN : ::.::::::::::::.:.:::::::.::.:::::::.::.::..::.::: .:.:. XP_005 MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEIS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP :.::::::::::..::: ::::::::.:::::::::::::::::::::.:::: :: :: XP_005 EGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR . :.:: : .:::::::. ::.: ::::::::::: . : ::. ::.::: .:.: :: XP_005 VKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN ...: :::.::.:::: :. :::::.:.:: ..:::. :::.:.::::::::::::::.: XP_005 VNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN :::::::::::::.::::: ::.::::. :::::::.::::.:: ::::::::::::::: XP_005 IQQARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE ::.::::::::::::::::..::...:.:. XP_005 GKVIQEIVDKSGVVRVRIEGDNENKLPRED------------------------------ 310 320 330 370 380 390 400 410 420 pF1KE2 NSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYH :::::::::::.::.:. :::.:: XP_005 ------------------------------------GMVPFVFVGTKESIGNVQVLLEYH 340 350 430 440 450 460 470 480 pF1KE2 LNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRG . :::::.:::.::::::::::::: :: : .:: XP_005 IAYLKEVEQLRMERLQIDEQLRQIG---------------------------SRSYSGRG 360 370 380 490 500 510 520 530 pF1KE2 HGRRGPGYTSG--TNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGG .:::::.:::: :::: :: :::::...::::::::: :..:.: .: . :: :: : XP_005 RGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAG-EDDRDSRHQRDSRRRPGGRG 390 400 410 420 430 440 540 550 560 570 580 590 pF1KE2 RG-QGGRGRGGGFKGNDDHSRTDNRP-RNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQ :. .::::::: :... : . . : :: : . . .: . .: :. XP_005 RSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQT---ADTDASESHHS---T 450 460 470 480 490 500 600 610 620 630 pF1KE2 NTSSEGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP : .. : :: .: XP_005 NRRRRSRRRRTDEDAVLMDGMTESDTASVNENGLDDSEKKPQRRNRSRRRRFRGQAEDRQ 510 520 530 540 550 560 >>XP_005247871 (OMIM: 600819) PREDICTED: fragile X menta (650 aa) initn: 1885 init1: 1670 opt: 1670 Z-score: 1334.3 bits: 257.1 E(87258): 1.4e-67 Smith-Waterman score: 2138; 58.6% identity (74.5% similar) in 616 aa overlap (1-610:1-543) 10 20 30 40 50 60 pF1KE2 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN : ::.::::::::::::.:.:::::::.::.:::::::.::.::..::.::: .:.:. XP_005 MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEIS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP :.::::::::::..::: ::::::::.:::::::::::::::::::::.:::: :: :: XP_005 EGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR . :.:: : .:::::::. ::.: ::::::::::: . : ::. ::.::: .:.: :: XP_005 VKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN ...: :::.::.:::: :. :::::.:.:: ..:::. :::.:.::::::::::::::.: XP_005 VNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN :::::::::::::.::::: ::.::::. :::::::.::::.:: ::::::::::::::: XP_005 IQQARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE ::.::::::::::::::::..::...:.:. XP_005 GKVIQEIVDKSGVVRVRIEGDNENKLPRED------------------------------ 310 320 330 370 380 390 400 410 420 pF1KE2 NSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYH :::::::::::.::.:. :::.:: XP_005 ------------------------------------GMVPFVFVGTKESIGNVQVLLEYH 340 350 430 440 450 460 470 pF1KE2 LNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNR-TDKEKSYVTDDGQGMG-RGSRPYRN . :::::.:::.::::::::::::: . :: .: .:::.:.::.. . .::: : . XP_005 IAYLKEVEQLRMERLQIDEQLRQIGMGFRPSSTRGPEKEKGYATDESTVSSVQGSRSYSG 360 370 380 390 400 410 480 490 500 510 520 530 pF1KE2 RGHGRRGPGYTSG--TNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGG ::.:::::.:::: :::: :: :::::...::::::::: :..:.: .: . :: :: XP_005 RGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAG-EDDRDSRHQRDSRRRPGG 420 430 440 450 460 470 540 550 560 570 580 590 pF1KE2 GGRG-QGGRGRGGGFKGNDDHSRTDNRP-RNPREAKGRTTDGSLQIRVDCNNERSVHTKT ::. .::::::: :... : . . : :: : . . .: . .: :. XP_005 RGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQ---TADTDASESHHS-- 480 490 500 510 520 600 610 620 630 pF1KE2 LQNTSSEGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP : .. : :: .: XP_005 -TNRRRRSRRRRTDEDAVLMDGMTESDTASVNENGLVTVADYISRAESQSRQRNLPRETL 530 540 550 560 570 580 632 residues in 1 query sequences 62035967 residues in 87258 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Jun 16 16:56:32 2017 done: Fri Jun 16 16:56:33 2017 Total Scan time: 5.920 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]