FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9244, 1654 aa 1>>>pF1KE9244 1654 - 1654 aa - 1654 aa Library: /omim/omim.rfq.tfa 64369986 residues in 92320 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.4757+/-0.000537; mu= -5.5588+/- 0.033 mean_var=433.5771+/-93.004, 0's: 0 Z-trim(116.3): 365 B-trim: 263 in 1/53 Lambda= 0.061594 statistics sampled from 28041 (28447) to 28041 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.308), width: 16 Scan time: 10.150 The best scores are: opt bits E(92320) NP_055800 (OMIM: 613529,613823,614852) centrosomal (1654) 10833 979.5 0 XP_024305643 (OMIM: 613529,613823,614852) centroso (1644) 8427 765.7 0 XP_011519677 (OMIM: 613529,613823,614852) centroso (1397) 7530 685.9 7.1e-196 XP_011519680 (OMIM: 613529,613823,614852) centroso (1362) 7522 685.2 1.1e-195 XP_011519676 (OMIM: 613529,613823,614852) centroso (1401) 7522 685.2 1.2e-195 XP_011519681 (OMIM: 613529,613823,614852) centroso (1341) 7518 684.8 1.4e-195 XP_011519675 (OMIM: 613529,613823,614852) centroso (1700) 7518 684.9 1.7e-195 XP_006720500 (OMIM: 613529,613823,614852) centroso (1710) 7518 684.9 1.7e-195 NP_001181927 (OMIM: 613529,613823,614852) centroso (1710) 7518 684.9 1.7e-195 XP_016877505 (OMIM: 613529,613823,614852) centroso ( 834) 4988 459.8 4.9e-128 XP_011519683 (OMIM: 613529,613823,614852) centroso (1055) 3409 319.6 1e-85 XP_016877504 (OMIM: 613529,613823,614852) centroso (1055) 3409 319.6 1e-85 NP_002464 (OMIM: 155100,160775,603622) myosin-9 [H (1960) 391 51.7 8.4e-05 XP_016861684 (OMIM: 602500) golgin subfamily B mem (3016) 373 50.3 0.00034 NP_001243417 (OMIM: 602500) golgin subfamily B mem (3184) 373 50.3 0.00036 NP_001353213 (OMIM: 602500) golgin subfamily B mem (3189) 373 50.3 0.00036 XP_006713654 (OMIM: 602500) golgin subfamily B mem (3189) 373 50.3 0.00036 NP_001353212 (OMIM: 602500) golgin subfamily B mem (3223) 373 50.3 0.00036 XP_016861682 (OMIM: 602500) golgin subfamily B mem (3224) 373 50.3 0.00036 NP_001243416 (OMIM: 602500) golgin subfamily B mem (3225) 373 50.3 0.00036 XP_016861681 (OMIM: 602500) golgin subfamily B mem (3225) 373 50.3 0.00036 XP_005247430 (OMIM: 602500) golgin subfamily B mem (3228) 373 50.3 0.00036 XP_016861680 (OMIM: 602500) golgin subfamily B mem (3228) 373 50.3 0.00036 XP_005247429 (OMIM: 602500) golgin subfamily B mem (3230) 373 50.3 0.00036 NP_004478 (OMIM: 602500) golgin subfamily B member (3259) 373 50.3 0.00036 XP_016861679 (OMIM: 602500) golgin subfamily B mem (3263) 373 50.3 0.00036 XP_006713652 (OMIM: 602500) golgin subfamily B mem (3263) 373 50.3 0.00036 NP_001353211 (OMIM: 602500) golgin subfamily B mem (3264) 373 50.3 0.00036 XP_016861678 (OMIM: 602500) golgin subfamily B mem (3264) 373 50.3 0.00036 XP_006713651 (OMIM: 602500) golgin subfamily B mem (3264) 373 50.3 0.00036 XP_011511001 (OMIM: 602500) golgin subfamily B mem (3269) 373 50.3 0.00036 XP_005247428 (OMIM: 602500) golgin subfamily B mem (3269) 373 50.3 0.00036 NP_001243415 (OMIM: 602500) golgin subfamily B mem (3269) 373 50.3 0.00036 XP_011520056 (OMIM: 612516) uveal autoantigen with (1164) 341 47.0 0.0013 XP_005254586 (OMIM: 612516) uveal autoantigen with (1392) 341 47.1 0.0014 XP_016877884 (OMIM: 612516) uveal autoantigen with (1399) 341 47.1 0.0014 NP_001008225 (OMIM: 612516) uveal autoantigen with (1403) 341 47.1 0.0014 XP_016877883 (OMIM: 612516) uveal autoantigen with (1405) 341 47.1 0.0014 NP_060473 (OMIM: 612516) uveal autoantigen with co (1416) 341 47.1 0.0014 XP_011520055 (OMIM: 612516) uveal autoantigen with (1425) 341 47.1 0.0015 XP_011520054 (OMIM: 612516) uveal autoantigen with (1436) 341 47.1 0.0015 XP_011537117 (OMIM: 605070) early endosome antigen (1365) 339 46.9 0.0016 NP_003557 (OMIM: 605070) early endosome antigen 1 (1411) 339 46.9 0.0016 XP_016875507 (OMIM: 605070) early endosome antigen (1417) 339 46.9 0.0016 XP_011537116 (OMIM: 605070) early endosome antigen (1453) 339 46.9 0.0017 XP_011507384 (OMIM: 243605,600236) centromere prot (3055) 347 47.9 0.0017 XP_016855575 (OMIM: 243605,600236) centromere prot (3114) 347 48.0 0.0017 NP_057427 (OMIM: 243605,600236) centromere protein (3114) 347 48.0 0.0017 XP_006719615 (OMIM: 179838) CAP-Gly domain-contain (1429) 329 46.0 0.003 XP_016875275 (OMIM: 179838) CAP-Gly domain-contain (1427) 327 45.8 0.0034 >>NP_055800 (OMIM: 613529,613823,614852) centrosomal pro (1654 aa) initn: 10833 init1: 10833 opt: 10833 Z-score: 5223.5 bits: 979.5 E(92320): 0 Smith-Waterman score: 10833; 100.0% identity (100.0% similar) in 1654 aa overlap (1-1654:1-1654) 10 20 30 40 50 60 pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE9 HHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 HHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACL 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE9 PCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE9 ICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAV 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE9 KKSKRNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KKSKRNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGS 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE9 KETHLEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KETHLEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAY 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KE9 PFLGTLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PFLGTLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLD 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KE9 VQEPPVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VQEPPVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGY 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KE9 LSDTEESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LSDTEESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSS 1570 1580 1590 1600 1610 1620 1630 1640 1650 pF1KE9 TLPSSVCQQPSRKLIVPLSSQQDSGFDSPFVNLD :::::::::::::::::::::::::::::::::: NP_055 TLPSSVCQQPSRKLIVPLSSQQDSGFDSPFVNLD 1630 1640 1650 >>XP_024305643 (OMIM: 613529,613823,614852) centrosomal (1644 aa) initn: 8421 init1: 8421 opt: 8427 Z-score: 4068.1 bits: 765.7 E(92320): 0 Smith-Waterman score: 10744; 99.3% identity (99.4% similar) in 1654 aa overlap (1-1654:1-1644) 10 20 30 40 50 60 pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE9 HHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 HHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACL 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE9 PCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 PCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE9 ICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAV ::::::::::::::::::::::::::::::::::::::. ::::::::::: XP_024 ICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPIST----------LPLTSEMLIAV 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 1380 pF1KE9 KKSKRNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 KKSKRNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGS 1320 1330 1340 1350 1360 1370 1390 1400 1410 1420 1430 1440 pF1KE9 KETHLEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 KETHLEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAY 1380 1390 1400 1410 1420 1430 1450 1460 1470 1480 1490 1500 pF1KE9 PFLGTLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 PFLGTLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLD 1440 1450 1460 1470 1480 1490 1510 1520 1530 1540 1550 1560 pF1KE9 VQEPPVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 VQEPPVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGY 1500 1510 1520 1530 1540 1550 1570 1580 1590 1600 1610 1620 pF1KE9 LSDTEESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 LSDTEESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSS 1560 1570 1580 1590 1600 1610 1630 1640 1650 pF1KE9 TLPSSVCQQPSRKLIVPLSSQQDSGFDSPFVNLD :::::::::::::::::::::::::::::::::: XP_024 TLPSSVCQQPSRKLIVPLSSQQDSGFDSPFVNLD 1620 1630 1640 >>XP_011519677 (OMIM: 613529,613823,614852) centrosomal (1397 aa) initn: 8416 init1: 7512 opt: 7530 Z-score: 3638.2 bits: 685.9 E(92320): 7.1e-196 Smith-Waterman score: 8305; 94.4% identity (95.0% similar) in 1380 aa overlap (1-1324:1-1380) 10 20 30 40 50 60 pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG 1090 1100 1110 1120 1130 1140 1150 pF1KE9 HHAQPLALQATEAEA--------------------------------------------- ::::::::::::::: XP_011 HHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLE 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 pF1KE9 -----------EENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG 1210 1220 1230 1240 1250 1260 1210 1220 1230 1240 1250 1260 pF1KE9 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ 1270 1280 1290 1300 1310 1320 1270 1280 1290 1300 1310 1320 pF1KE9 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK ::::::::::::::::::::::::::::::::::. .. . .::...::: XP_011 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISKPDNLGGDGETARCILLLLITISKSK 1330 1340 1350 1360 1370 1380 1330 1340 1350 1360 1370 1380 pF1KE9 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH XP_011 NREGKLFGLGKLCHLNS 1390 >>XP_011519680 (OMIM: 613529,613823,614852) centrosomal (1362 aa) initn: 8409 init1: 7512 opt: 7522 Z-score: 3634.5 bits: 685.2 E(92320): 1.1e-195 Smith-Waterman score: 8299; 95.4% identity (95.6% similar) in 1362 aa overlap (1-1306:1-1362) 10 20 30 40 50 60 pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG 1090 1100 1110 1120 1130 1140 1150 pF1KE9 HHAQPLALQATEAEA--------------------------------------------- ::::::::::::::: XP_011 HHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLE 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 pF1KE9 -----------EENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG 1210 1220 1230 1240 1250 1260 1210 1220 1230 1240 1250 1260 pF1KE9 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ 1270 1280 1290 1300 1310 1320 1270 1280 1290 1300 1310 1320 pF1KE9 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK ::::::::::::::::::::::::::::::::::. : .. XP_011 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISNLCCSPSS 1330 1340 1350 1360 1330 1340 1350 1360 1370 1380 pF1KE9 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH >>XP_011519676 (OMIM: 613529,613823,614852) centrosomal (1401 aa) initn: 7512 init1: 7512 opt: 7522 Z-score: 3634.4 bits: 685.2 E(92320): 1.2e-195 Smith-Waterman score: 8353; 95.9% identity (95.9% similar) in 1364 aa overlap (1-1308:1-1364) 10 20 30 40 50 60 pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG 1090 1100 1110 1120 1130 1140 1150 pF1KE9 HHAQPLALQATEAEA--------------------------------------------- ::::::::::::::: XP_011 HHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLE 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 pF1KE9 -----------EENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG 1210 1220 1230 1240 1250 1260 1210 1220 1230 1240 1250 1260 pF1KE9 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ 1270 1280 1290 1300 1310 1320 1270 1280 1290 1300 1310 1320 pF1KE9 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK :::::::::::::::::::::::::::::::::::::::::::: XP_011 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSGDGILLCHPGWRAVAQ 1330 1340 1350 1360 1370 1380 1330 1340 1350 1360 1370 1380 pF1KE9 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH XP_011 ITATEPRLQLLGSNDPPRSAS 1390 1400 >>XP_011519681 (OMIM: 613529,613823,614852) centrosomal (1341 aa) initn: 8274 init1: 7512 opt: 7518 Z-score: 3632.7 bits: 684.8 E(92320): 1.4e-195 Smith-Waterman score: 8163; 95.3% identity (95.6% similar) in 1338 aa overlap (1-1282:1-1338) 10 20 30 40 50 60 pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG 1090 1100 1110 1120 1130 1140 1150 pF1KE9 HHAQPLALQATEAEA--------------------------------------------- ::::::::::::::: XP_011 HHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLE 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 pF1KE9 -----------EENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG 1210 1220 1230 1240 1250 1260 1210 1220 1230 1240 1250 1260 pF1KE9 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ 1270 1280 1290 1300 1310 1320 1270 1280 1290 1300 1310 1320 pF1KE9 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK ::::::::::. .. .: XP_011 QILQDDGKEGTAPNFRDADCS 1330 1340 >>XP_011519675 (OMIM: 613529,613823,614852) centrosomal (1700 aa) initn: 9858 init1: 7512 opt: 7518 Z-score: 3631.4 bits: 684.9 E(92320): 1.7e-195 Smith-Waterman score: 10523; 96.0% identity (96.1% similar) in 1696 aa overlap (1-1640:1-1686) 10 20 30 40 50 60 pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG 1090 1100 1110 1120 1130 1140 1150 pF1KE9 HHAQPLALQATEAEA--------------------------------------------- ::::::::::::::: XP_011 HHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLE 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 pF1KE9 -----------EENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG 1210 1220 1230 1240 1250 1260 1210 1220 1230 1240 1250 1260 pF1KE9 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ 1270 1280 1290 1300 1310 1320 1270 1280 1290 1300 1310 1320 pF1KE9 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK ::::::::::::::::::::::::::::::::::. ::::::::::::::: XP_011 QILQDDGKEGAEKKIMNAASKLATMAKLLETPIST----------LPLTSEMLIAVKKSK 1330 1340 1350 1360 1370 1330 1340 1350 1360 1370 1380 pF1KE9 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH 1380 1390 1400 1410 1420 1430 1390 1400 1410 1420 1430 1440 pF1KE9 LEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAYPFLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAYPFLG 1440 1450 1460 1470 1480 1490 1450 1460 1470 1480 1490 1500 pF1KE9 TLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLDVQEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLDVQEP 1500 1510 1520 1530 1540 1550 1510 1520 1530 1540 1550 1560 pF1KE9 PVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGYLSDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGYLSDT 1560 1570 1580 1590 1600 1610 1570 1580 1590 1600 1610 1620 pF1KE9 EESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSSTLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSSTLPS 1620 1630 1640 1650 1660 1670 1630 1640 1650 pF1KE9 SVCQQPSRKLIVPLSSQQDSGFDSPFVNLD :::::::::::::::: XP_011 SVCQQPSRKLIVPLSSQQDSGFDSPFVNLD 1680 1690 1700 >>XP_006720500 (OMIM: 613529,613823,614852) centrosomal (1710 aa) initn: 7512 init1: 7512 opt: 7518 Z-score: 3631.3 bits: 684.9 E(92320): 1.7e-195 Smith-Waterman score: 10554; 96.7% identity (96.7% similar) in 1686 aa overlap (1-1630:1-1686) 10 20 30 40 50 60 pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG 1090 1100 1110 1120 1130 1140 1150 pF1KE9 HHAQPLALQATEAEA--------------------------------------------- ::::::::::::::: XP_006 HHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLE 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 pF1KE9 -----------EENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG ::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG 1210 1220 1230 1240 1250 1260 1210 1220 1230 1240 1250 1260 pF1KE9 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ 1270 1280 1290 1300 1310 1320 1270 1280 1290 1300 1310 1320 pF1KE9 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK 1330 1340 1350 1360 1370 1380 1330 1340 1350 1360 1370 1380 pF1KE9 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH 1390 1400 1410 1420 1430 1440 1390 1400 1410 1420 1430 1440 pF1KE9 LEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAYPFLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAYPFLG 1450 1460 1470 1480 1490 1500 1450 1460 1470 1480 1490 1500 pF1KE9 TLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLDVQEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLDVQEP 1510 1520 1530 1540 1550 1560 1510 1520 1530 1540 1550 1560 pF1KE9 PVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGYLSDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGYLSDT 1570 1580 1590 1600 1610 1620 1570 1580 1590 1600 1610 1620 pF1KE9 EESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSSTLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSSTLPS 1630 1640 1650 1660 1670 1680 1630 1640 1650 pF1KE9 SVCQQPSRKLIVPLSSQQDSGFDSPFVNLD :::::: XP_006 SVCQQPSRKLIVPLSSQQDSGFDSPFVNLD 1690 1700 1710 >>NP_001181927 (OMIM: 613529,613823,614852) centrosomal (1710 aa) initn: 7512 init1: 7512 opt: 7518 Z-score: 3631.3 bits: 684.9 E(92320): 1.7e-195 Smith-Waterman score: 10554; 96.7% identity (96.7% similar) in 1686 aa overlap (1-1630:1-1686) 10 20 30 40 50 60 pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG 1090 1100 1110 1120 1130 1140 1150 pF1KE9 HHAQPLALQATEAEA--------------------------------------------- ::::::::::::::: NP_001 HHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLE 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 pF1KE9 -----------EENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG 1210 1220 1230 1240 1250 1260 1210 1220 1230 1240 1250 1260 pF1KE9 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ 1270 1280 1290 1300 1310 1320 1270 1280 1290 1300 1310 1320 pF1KE9 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK 1330 1340 1350 1360 1370 1380 1330 1340 1350 1360 1370 1380 pF1KE9 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH 1390 1400 1410 1420 1430 1440 1390 1400 1410 1420 1430 1440 pF1KE9 LEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAYPFLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAYPFLG 1450 1460 1470 1480 1490 1500 1450 1460 1470 1480 1490 1500 pF1KE9 TLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLDVQEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLDVQEP 1510 1520 1530 1540 1550 1560 1510 1520 1530 1540 1550 1560 pF1KE9 PVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGYLSDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGYLSDT 1570 1580 1590 1600 1610 1620 1570 1580 1590 1600 1610 1620 pF1KE9 EESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSSTLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSSTLPS 1630 1640 1650 1660 1670 1680 1630 1640 1650 pF1KE9 SVCQQPSRKLIVPLSSQQDSGFDSPFVNLD :::::: NP_001 SVCQQPSRKLIVPLSSQQDSGFDSPFVNLD 1690 1700 1710 >>XP_016877505 (OMIM: 613529,613823,614852) centrosomal (834 aa) initn: 4954 init1: 4954 opt: 4988 Z-score: 2420.3 bits: 459.8 E(92320): 4.9e-128 Smith-Waterman score: 4988; 95.2% identity (97.2% similar) in 813 aa overlap (1-807:1-813) 10 20 30 40 50 60 pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD 670 680 690 700 710 720 730 740 750 760 770 pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKI-----KEKLIQQLEKEWQS :::::::::::::::::::::::::::::::::::::::: .:. ...:. : .. XP_016 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKRQLLEEREEYVSKLQVELEK 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE9 KLDQTIKAMKKKTL-DCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKG : ..:. :.: : : .. : . :.:: : XP_016 KYQDTLMMEKSKWLKDQETDIKQQVESEVILAKAHWDKEEQEVWIKISFWSPHF 790 800 810 820 830 840 850 860 870 880 890 pF1KE9 AMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVS 1654 residues in 1 query sequences 64369986 residues in 92320 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Oct 3 17:22:39 2019 done: Thu Oct 3 17:22:41 2019 Total Scan time: 10.150 Total Display time: 0.510 Function used was FASTA [36.3.4 Apr, 2011]