Result of FASTA (omim) for
pFN21AE2578
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2578, 1168 aa
1>>>pF1KE2578 1168 - 1168 aa - 1168 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1003+/-0.000394; mu= 19.1799+/- 0.025
mean_var=91.0047+/-18.369, 0's: 0 Z-trim(113.6): 112 B-trim: 0 in 0/53
Lambda= 0.134444
statistics sampled from 22851 (22968) to 22851 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.615), E-opt: 0.2 (0.269), width: 16
Scan time: 9.850
The best scores are: opt bits E(85289)
XP_006719273 (OMIM: 600294,616287) PREDICTED: aden (1168) 7768 1517.7 0
NP_056085 (OMIM: 600294,616287) adenylate cyclase (1168) 7768 1517.7 0
NP_899200 (OMIM: 600293,606703) adenylate cyclase (1261) 5051 990.8 0
XP_016874232 (OMIM: 600294,616287) PREDICTED: aden (1067) 4457 875.5 0
NP_001186571 (OMIM: 600293,606703) adenylate cycla ( 911) 4401 864.6 0
XP_005247134 (OMIM: 600293,606703) PREDICTED: aden (1286) 3392 669.0 5.3e-191
XP_016861128 (OMIM: 600293,606703) PREDICTED: aden ( 920) 2747 543.8 1.9e-153
XP_005247135 (OMIM: 600293,606703) PREDICTED: aden ( 936) 2742 542.8 3.7e-153
XP_011510662 (OMIM: 600293,606703) PREDICTED: aden ( 923) 2735 541.5 9.3e-153
XP_011510661 (OMIM: 600293,606703) PREDICTED: aden ( 953) 2735 541.5 9.6e-153
XP_016861127 (OMIM: 600293,606703) PREDICTED: aden ( 920) 2734 541.3 1.1e-152
XP_006713546 (OMIM: 600293,606703) PREDICTED: aden ( 919) 2733 541.1 1.2e-152
NP_001105 (OMIM: 600385) adenylate cyclase type 7 (1080) 1795 359.2 8.1e-98
XP_016878384 (OMIM: 600385) PREDICTED: adenylate c (1080) 1795 359.2 8.1e-98
NP_065433 (OMIM: 103071) adenylate cyclase type 2 (1091) 1795 359.2 8.2e-98
NP_001185521 (OMIM: 600292) adenylate cyclase type (1077) 1755 351.4 1.8e-95
NP_001185497 (OMIM: 600292) adenylate cyclase type (1077) 1755 351.4 1.8e-95
NP_640340 (OMIM: 600292) adenylate cyclase type 4 (1077) 1755 351.4 1.8e-95
XP_016878386 (OMIM: 600385) PREDICTED: adenylate c ( 886) 1677 336.2 5.4e-91
XP_016878385 (OMIM: 600385) PREDICTED: adenylate c ( 886) 1677 336.2 5.4e-91
XP_011521139 (OMIM: 600385) PREDICTED: adenylate c (1086) 1677 336.3 6.4e-91
XP_011521141 (OMIM: 600385) PREDICTED: adenylate c (1086) 1677 336.3 6.4e-91
XP_011521144 (OMIM: 600385) PREDICTED: adenylate c (1086) 1677 336.3 6.4e-91
XP_011521142 (OMIM: 600385) PREDICTED: adenylate c (1086) 1677 336.3 6.4e-91
XP_011521140 (OMIM: 600385) PREDICTED: adenylate c (1086) 1677 336.3 6.4e-91
XP_011521137 (OMIM: 600385) PREDICTED: adenylate c (1086) 1677 336.3 6.4e-91
XP_011521138 (OMIM: 600385) PREDICTED: adenylate c (1086) 1677 336.3 6.4e-91
XP_011510663 (OMIM: 600293,606703) PREDICTED: aden ( 845) 1668 334.5 1.7e-90
XP_006713547 (OMIM: 600293,606703) PREDICTED: aden ( 845) 1668 334.5 1.7e-90
XP_016861129 (OMIM: 600293,606703) PREDICTED: aden ( 845) 1668 334.5 1.7e-90
NP_004027 (OMIM: 600291) adenylate cyclase type 3 (1144) 1556 312.8 7.7e-84
NP_001307542 (OMIM: 600291) adenylate cyclase type (1145) 1556 312.8 7.7e-84
NP_001106 (OMIM: 103070) adenylate cyclase type 8 (1251) 1498 301.6 2e-80
XP_005250826 (OMIM: 103070) PREDICTED: adenylate c (1221) 1489 299.8 6.6e-80
XP_016858682 (OMIM: 600291) PREDICTED: adenylate c ( 903) 1474 296.9 3.9e-79
XP_016858681 (OMIM: 600291) PREDICTED: adenylate c ( 904) 1474 296.9 3.9e-79
XP_005249641 (OMIM: 103072,610154,610154) PREDICTE ( 979) 1317 266.4 6.1e-70
NP_066939 (OMIM: 103072,610154,610154) adenylate c (1119) 1317 266.5 6.8e-70
XP_016868495 (OMIM: 103070) PREDICTED: adenylate c (1155) 1317 266.5 7e-70
XP_006716564 (OMIM: 103070) PREDICTED: adenylate c (1185) 1317 266.5 7.1e-70
XP_005249642 (OMIM: 103072,610154,610154) PREDICTE ( 563) 1312 265.3 7.6e-70
XP_016868496 (OMIM: 103070) PREDICTED: adenylate c ( 646) 1305 264.0 2.2e-69
XP_016858678 (OMIM: 600291) PREDICTED: adenylate c (1139) 1251 253.7 4.9e-66
XP_011530795 (OMIM: 600291) PREDICTED: adenylate c (1140) 1251 253.7 4.9e-66
NP_001268697 (OMIM: 103072,610154,610154) adenylat ( 338) 1164 236.5 2.2e-61
XP_016858679 (OMIM: 600291) PREDICTED: adenylate c (1098) 1068 218.2 2.3e-55
XP_016858676 (OMIM: 600291) PREDICTED: adenylate c (1163) 1068 218.2 2.4e-55
XP_011530793 (OMIM: 600291) PREDICTED: adenylate c (1164) 1068 218.2 2.4e-55
XP_011530796 (OMIM: 600291) PREDICTED: adenylate c (1120) 1066 217.8 3.1e-55
XP_016858677 (OMIM: 600291) PREDICTED: adenylate c (1149) 910 187.5 4e-46
>>XP_006719273 (OMIM: 600294,616287) PREDICTED: adenylat (1168 aa)
initn: 7768 init1: 7768 opt: 7768 Z-score: 8137.8 bits: 1517.7 E(85289): 0
Smith-Waterman score: 7768; 100.0% identity (100.0% similar) in 1168 aa overlap (1-1168:1-1168)
10 20 30 40 50 60
pF1KE2 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
1090 1100 1110 1120 1130 1140
1150 1160
pF1KE2 YQLECRGVVKVKGKGEMTTYFLNGGPSS
::::::::::::::::::::::::::::
XP_006 YQLECRGVVKVKGKGEMTTYFLNGGPSS
1150 1160
>>NP_056085 (OMIM: 600294,616287) adenylate cyclase type (1168 aa)
initn: 7768 init1: 7768 opt: 7768 Z-score: 8137.8 bits: 1517.7 E(85289): 0
Smith-Waterman score: 7768; 100.0% identity (100.0% similar) in 1168 aa overlap (1-1168:1-1168)
10 20 30 40 50 60
pF1KE2 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
1090 1100 1110 1120 1130 1140
1150 1160
pF1KE2 YQLECRGVVKVKGKGEMTTYFLNGGPSS
::::::::::::::::::::::::::::
NP_056 YQLECRGVVKVKGKGEMTTYFLNGGPSS
1150 1160
>>NP_899200 (OMIM: 600293,606703) adenylate cyclase type (1261 aa)
initn: 4661 init1: 2353 opt: 5051 Z-score: 5289.2 bits: 990.8 E(85289): 0
Smith-Waterman score: 5051; 68.0% identity (83.7% similar) in 1167 aa overlap (16-1166:100-1258)
10 20 30 40
pF1KE2 MSWFSGLLVPKVDERKTAWGERNGQ-----KRSRRRGTRAGGFCT
:.:: ::.:. .: .:::. .::
NP_899 ASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTR
70 80 90 100 110 120
50 60 70 80 90
pF1KE2 PRYMSCLRDAEPPSPTPAGPPRCPWQDDAFI--RRGGPGKGKELGLRAVALGFEDTEVTT
. . . . .: : . .. . ::: . :: :: : . . .
NP_899 APPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGS
130 140 150 160 170 180
100 110 120 130 140 150
pF1KE2 TAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAV
.: . . ..: :: : : :.:.:.::.: : :::::::::::..::::::.::::
NP_899 SADSGSGAGPGAVLSLGACCLA-LLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAV
190 200 210 220 230 240
160 170 180 190 200 210
pF1KE2 LVLLTAVLLAFHAAPARP--QPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVL
:::. :.::::: ::: : :.:.:: :..... . :.::: .:.:: : .. :...
NP_899 LVLVCLVMLAFHA--ARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALI
250 260 270 280 290 300
220 230 240 250 260 270
pF1KE2 GILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAW
... :::: : : .::: : :.: :::.: :::::.:::::::::. ::.::: .:
NP_899 AVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIAL
310 320 330 340 350 360
280 290 300 310 320 330
pF1KE2 QLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENR
. : : :: ::: .:::.: :::..:.:::::::::::::::::: :::::: :.::.
NP_899 RTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQ
370 380 390 400 410 420
340 350 360 370 380 390
pF1KE2 QQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT
:::::::::::.::::::: :::.:.::::::::::::::::::::::::::::::::::
NP_899 QQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT
430 440 450 460 470 480
400 410 420 430 440 450
pF1KE2 AQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
NP_899 AQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIE
490 500 510 520 530 540
460 470 480 490 500 510
pF1KE2 AISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHI
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
NP_899 AISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHI
550 560 570 580 590 600
520 530 540 550 560 570
pF1KE2 TRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANS
:.:::.::::::::::: ::::::::::. ::::::: .:::::::::.::..: :.::
NP_899 TKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNS
610 620 630 640 650 660
580 590 600 610 620 630
pF1KE2 MEGLMPRWVPDRAFSR----TKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAI
. :.: .: : .. :: ...::..: :: ...:.. ::::::::::.:::
NP_899 IGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDP-KD-KNAQESANPEDEVDEFLGRAI
670 680 690 700 710 720
640 650 660 670 680 690
pF1KE2 DARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFP
::::::.::..:::.:::::.. :::::::..:: ::::::::: ::: ::::.:. : :
NP_899 DARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVP
730 740 750 760 770 780
700 710 720 730 740 750
pF1KE2 HSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLL
:: .::..: . ::: ..:.. ..::: .:::. :: :::.::::. .:: ::.:.. :
NP_899 HSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITL
790 800 810 820 830 840
760 770 780 790 800 810
pF1KE2 VFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQ--LNYSLGLDAPLCEGTMPTC
:: .:..:::::: . .: :. :.. ....:::. . .::::: . .: . :.:
NP_899 VFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNC
850 860 870 880 890 900
820 830 840 850 860 870
pF1KE2 SFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLG
.::::: ..:::::: ::::.:: ::::...... ::: ::.. : .:.::: :::.
NP_899 NFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIY-VLIVEVPGVTLFDNADLLVT
910 920 930 940 950 960
880 890 900 910 920
pF1KE2 VHGLASSNETFDGLDCPA-AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQ
.... :. . .:: : .:::: .::.:. ::.:::::::::::::::::::::::
NP_899 ANAIDFFNNGTS--QCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQ
970 980 990 1000 1010 1020
930 940 950 960 970 980
pF1KE2 ATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFS
:: :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 ATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFS
1030 1040 1050 1060 1070 1080
990 1000 1010 1020 1030 1040
pF1KE2 EFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYD
::::::::::::::::::::::::::::::::.:::::::::::::::::::::: ::::
NP_899 EFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYD
1090 1100 1110 1120 1130 1140
1050 1060 1070 1080 1090 1100
pF1KE2 QVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGN
.::..:: ::::.::.::.:::.::::::::::::::::.::::::::::::::::::::
NP_899 KVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGN
1150 1160 1170 1180 1190 1200
1110 1120 1130 1140 1150 1160
pF1KE2 TVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
::::.:::::::::::::::::.::::::. ::::::::::::::::: ::::::::
NP_899 TVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
1210 1220 1230 1240 1250 1260
>>XP_016874232 (OMIM: 600294,616287) PREDICTED: adenylat (1067 aa)
initn: 4457 init1: 4457 opt: 4457 Z-score: 4667.6 bits: 875.5 E(85289): 0
Smith-Waterman score: 6908; 91.4% identity (91.4% similar) in 1168 aa overlap (1-1168:1-1067)
10 20 30 40 50 60
pF1KE2 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
XP_016 ------------------------------------------------------------
730 740 750 760 770 780
pF1KE2 GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLT
:::::::::::::::::::
XP_016 -----------------------------------------FTCNHTPIRSCAARMLNLT
670
790 800 810 820 830 840
pF1KE2 PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA
680 690 700 710 720 730
850 860 870 880 890 900
pF1KE2 MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
740 750 760 770 780 790
910 920 930 940 950 960
pF1KE2 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
800 810 820 830 840 850
970 980 990 1000 1010 1020
pF1KE2 LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
860 870 880 890 900 910
1030 1040 1050 1060 1070 1080
pF1KE2 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
920 930 940 950 960 970
1090 1100 1110 1120 1130 1140
pF1KE2 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
980 990 1000 1010 1020 1030
1150 1160
pF1KE2 YQLECRGVVKVKGKGEMTTYFLNGGPSS
::::::::::::::::::::::::::::
XP_016 YQLECRGVVKVKGKGEMTTYFLNGGPSS
1040 1050 1060
>>NP_001186571 (OMIM: 600293,606703) adenylate cyclase t (911 aa)
initn: 4072 init1: 2322 opt: 4401 Z-score: 4609.9 bits: 864.6 E(85289): 0
Smith-Waterman score: 4401; 74.7% identity (88.8% similar) in 900 aa overlap (274-1166:14-908)
250 260 270 280 290 300
pF1KE2 FFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIG
:. : . : . ..: .:::.: :::..:
NP_001 MKSQKEGCCSRGDLSIQTGPGGEWAPRRLVSNVLIFSCTNIVG
10 20 30 40
310 320 330 340 350 360
pF1KE2 ICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKE
.:::::::::::::::::: :::::: :.::.:::::::::::.::::::: :::.:.:
NP_001 VCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQE
50 60 70 80 90 100
370 380 390 400 410 420
pF1KE2 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
110 120 130 140 150 160
430 440 450 460 470 480
pF1KE2 KILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
NP_001 KILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
170 180 190 200 210 220
490 500 510 520 530 540
pF1KE2 VLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLK
::::::::::::::::::::::::::.:::::::.:::.::::::::::: :::::::::
NP_001 VLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLK
230 240 250 260 270 280
550 560 570 580 590
pF1KE2 EQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR----TKDSKAF
:. ::::::: .:::::::::.::..: :.::. :.: .: : .. :: .
NP_001 EHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEM
290 300 310 320 330 340
600 610 620 630 640 650
pF1KE2 RQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEK
..::..: :: ...:.. ::::::::::.:::::::::.::..:::.:::::.. ::::
NP_001 KRMGFEDP-KD-KNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEK
350 360 370 380 390 400
660 670 680 690 700 710
pF1KE2 KYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYS
:::..:: ::::::::: ::: ::::.:. : ::: .::..: . ::: ..:.. ..::
NP_001 KYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYS
410 420 430 440 450 460
720 730 740 750 760 770
pF1KE2 CGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNL
: .:::. :: :::.::::. .:: ::.:.. ::: .:..:::::: . .: :. :.
NP_001 CVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNI
470 480 490 500 510 520
780 790 800 810 820 830
pF1KE2 TPADITACHLQQ--LNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIG
. ....:::. . .::::: . .: . :.:.::::: ..:::::: ::::.:: ::
NP_001 SASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIG
530 540 550 560 570 580
840 850 860 870 880 890
pF1KE2 KLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPA-AGRVALKY
::...... ::: ::.. : .:.::: :::. .... :. . .:: : .::::
NP_001 KLVLMLAIELIY-VLIVEVPGVTLFDNADLLVTANAIDFFNNGTS--QCPEHATKVALKV
590 600 610 620 630
900 910 920 930 940 950
pF1KE2 MTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDV
.::.:. ::.::::::::::::::::::::::::: ::::::::::::::::::::::::
NP_001 VTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDV
640 650 660 670 680 690
960 970 980 990 1000 1010
pF1KE2 AAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFD
700 710 720 730 740 750
1020 1030 1040 1050 1060 1070
pF1KE2 EIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEH
:::::.:::::::::::::::::::::: ::::.::..:: ::::.::.::.:::.::::
NP_001 EIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEH
760 770 780 790 800 810
1080 1090 1100 1110 1120 1130
pF1KE2 SFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL
::::::::::::.::::::::::::::::::::::::.:::::::::::::::::.::::
NP_001 SFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL
820 830 840 850 860 870
1140 1150 1160
pF1KE2 AAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
::. ::::::::::::::::: ::::::::
NP_001 AANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
880 890 900 910
>>XP_005247134 (OMIM: 600293,606703) PREDICTED: adenylat (1286 aa)
initn: 4915 init1: 2353 opt: 3392 Z-score: 3550.0 bits: 669.0 E(85289): 5.3e-191
Smith-Waterman score: 5000; 66.7% identity (82.1% similar) in 1190 aa overlap (16-1166:100-1283)
10 20 30 40
pF1KE2 MSWFSGLLVPKVDERKTAWGERNGQ-----KRSRRRGTRAGGFCT
:.:: ::.:. .: .:::. .::
XP_005 ASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTR
70 80 90 100 110 120
50 60 70 80 90
pF1KE2 PRYMSCLRDAEPPSPTPAGPPRCPWQDDAFI--RRGGPGKGKELGLRAVALGFEDTEVTT
. . . . .: : . .. . ::: . :: :: : . . .
XP_005 APPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGS
130 140 150 160 170 180
100 110 120 130 140 150
pF1KE2 TAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAV
.: . . ..: :: : : :.:.:.::.: : :::::::::::..::::::.::::
XP_005 SADSGSGAGPGAVLSLGACCLA-LLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAV
190 200 210 220 230 240
160 170 180 190 200 210
pF1KE2 LVLLTAVLLAFHAAPARP--QPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVL
:::. :.::::: ::: : :.:.:: :..... . :.::: .:.:: : .. :...
XP_005 LVLVCLVMLAFHA--ARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALI
250 260 270 280 290 300
220 230 240 250 260 270
pF1KE2 GILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAW
... :::: : : .::: : :.: :::.: :::::.:::::::::. ::.::: .:
XP_005 AVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIAL
310 320 330 340 350 360
280 290 300 310 320 330
pF1KE2 QLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENR
. : : :: ::: .:::.: :::..:.:::::::::::::::::: :::::: :.::.
XP_005 RTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQ
370 380 390 400 410 420
340 350 360 370 380 390
pF1KE2 QQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT
:::::::::::.::::::: :::.:.::::::::::::::::::::::::::::::::::
XP_005 QQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT
430 440 450 460 470 480
400 410 420 430 440 450
pF1KE2 AQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_005 AQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIE
490 500 510 520 530 540
460 470 480 490 500 510
pF1KE2 AISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHI
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
XP_005 AISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHI
550 560 570 580 590 600
520 530 540 550 560 570
pF1KE2 TRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANS
:.:::.::::::::::: ::::::::::. ::::::: .:::::::::.::..: :.::
XP_005 TKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNS
610 620 630 640 650 660
580 590 600 610 620 630
pF1KE2 MEGLMPRWVPDRAFSR----TKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAI
. :.: .: : .. :: ...::..: :: ...:.. ::::::::::.:::
XP_005 IGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDP-KD-KNAQESANPEDEVDEFLGRAI
670 680 690 700 710 720
640 650 660 670 680 690
pF1KE2 DARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFP
::::::.::..:::.:::::.. :::::::..:: ::::::::: ::: ::::.:. : :
XP_005 DARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVP
730 740 750 760 770 780
700 710 720 730 740 750
pF1KE2 HSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLL
:: .::..: . ::: ..:.. ..::: .:::. :: :::.::::. .:: ::.:.. :
XP_005 HSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITL
790 800 810 820 830 840
760 770 780 790 800 810
pF1KE2 VFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQ--LNYSLGLDAPLCEGTMPTC
:: .:..:::::: . .: :. :.. ....:::. . .::::: . .: . :.:
XP_005 VFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNC
850 860 870 880 890 900
820 830 840 850 860 870
pF1KE2 SFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLG
.::::: ..:::::: ::::.:: ::::...... ::: ::.. : .:.::: :::.
XP_005 NFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIY-VLIVEVPGVTLFDNADLLVT
910 920 930 940 950 960
880 890 900
pF1KE2 VHGLASSNETFD---------------GLDCPA---------AGRVALKYMTPVILLVFA
.... :. . : :. : .:::: .::.:. ::.
XP_005 ANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFV
970 980 990 1000 1010 1020
910 920 930 940 950 960
pF1KE2 LALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR
::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
XP_005 LALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR
1030 1040 1050 1060 1070 1080
970 980 990 1000 1010 1020
pF1KE2 NDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_005 NDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQ
1090 1100 1110 1120 1130 1140
1030 1040 1050 1060 1070 1080
pF1KE2 LEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIG
:::::::::::::::::: ::::.::..:: ::::.::.::.:::.::::::::::::::
XP_005 LEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIG
1150 1160 1170 1180 1190 1200
1090 1100 1110 1120 1130 1140
pF1KE2 LNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECR
::.::::::::::::::::::::::::.:::::::::::::::::.::::::. ::::::
XP_005 LNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECR
1210 1220 1230 1240 1250 1260
1150 1160
pF1KE2 GVVKVKGKGEMTTYFLNGGPSS
::::::::::: ::::::::
XP_005 GVVKVKGKGEMMTYFLNGGPPLS
1270 1280
>>XP_016861128 (OMIM: 600293,606703) PREDICTED: adenylat (920 aa)
initn: 4338 init1: 1776 opt: 2747 Z-score: 2876.0 bits: 543.8 E(85289): 1.9e-153
Smith-Waterman score: 4355; 73.5% identity (87.0% similar) in 911 aa overlap (286-1166:10-917)
260 270 280 290 300 310
pF1KE2 RMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQR
: .: .:::.: :::..:.:::::::::::
XP_016 MQTSACCPEWAKLVSNVLIFSCTNIVGVCTHYPAEVSQR
10 20 30
320 330 340 350 360 370
pF1KE2 QAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKH
::::::: :::::: :.::.:::::::::::.::::::: :::.:.:::::::::::::
XP_016 QAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKH
40 50 60 70 80 90
380 390 400 410 420 430
pF1KE2 DNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSG
100 110 120 130 140 150
440 450 460 470 480 490
pF1KE2 LPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVW
::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
XP_016 LPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVW
160 170 180 190 200 210
500 510 520 530 540 550
pF1KE2 SNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGA
::::::::::::::.:::::::.:::.::::::::::: ::::::::::. :::::::
XP_016 SNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRC
220 230 240 250 260 270
560 570 580 590 600 610
pF1KE2 SQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR----TKDSKAFRQMGIDDSSKDN
.:::::::::.::..: :.::. :.: .: : .. :: ...::..: ::
XP_016 TQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDP-KD-
280 290 300 310 320 330
620 630 640 650 660 670
pF1KE2 RGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGA
...:.. ::::::::::.:::::::::.::..:::.:::::.. :::::::..:: ::::
XP_016 KNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGA
340 350 360 370 380 390
680 690 700 710 720 730
pF1KE2 YVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRL
::::: ::: ::::.:. : ::: .::..: . ::: ..:.. ..::: .:::. :: :
XP_016 YVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTL
400 410 420 430 440 450
740 750 760 770 780 790
pF1KE2 SRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQ
::.::::. .:: ::.:.. ::: .:..:::::: . .: :. :.. ....:::. .
XP_016 SRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAE
460 470 480 490 500 510
800 810 820 830 840
pF1KE2 --LNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIY
.::::: . .: . :.:.::::: ..:::::: ::::.:: ::::...... :::
XP_016 SAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIY
520 530 540 550 560 570
850 860 870 880
pF1KE2 LVLLLLGPPATIFDNYDLLLGVHGLASSNETFD---------------GLDCPA------
::.. : .:.::: :::. .... :. . : :.
XP_016 -VLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQS
580 590 600 610 620 630
890 900 910 920 930 940
pF1KE2 ---AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNR
: .:::: .::.:. ::.::::::::::::::::::::::::: :::::::::::::
XP_016 PEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNR
640 650 660 670 680 690
950 960 970 980 990 1000
pF1KE2 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL
700 710 720 730 740 750
1010 1020 1030 1040 1050 1060
pF1KE2 RLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMR
::::::::::::::::.:::::::::::::::::::::: ::::.::..:: ::::.::.
XP_016 RLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMK
760 770 780 790 800 810
1070 1080 1090 1100 1110 1120
pF1KE2 LMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDR
::.:::.::::::::::::::::.::::::::::::::::::::::::.:::::::::::
XP_016 LMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDR
820 830 840 850 860 870
1130 1140 1150 1160
pF1KE2 IQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
::::::.::::::. ::::::::::::::::: ::::::::
XP_016 IQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
880 890 900 910 920
>>XP_005247135 (OMIM: 600293,606703) PREDICTED: adenylat (936 aa)
initn: 4326 init1: 1764 opt: 2742 Z-score: 2870.7 bits: 542.8 E(85289): 3.7e-153
Smith-Waterman score: 4350; 72.8% identity (86.6% similar) in 923 aa overlap (274-1166:14-933)
250 260 270 280 290 300
pF1KE2 FFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIG
:. : . : . ..: .:::.: :::..:
XP_005 MKSQKEGCCSRGDLSIQTGPGGEWAPRRLVSNVLIFSCTNIVG
10 20 30 40
310 320 330 340 350 360
pF1KE2 ICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKE
.:::::::::::::::::: :::::: :.::.:::::::::::.::::::: :::.:.:
XP_005 VCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQE
50 60 70 80 90 100
370 380 390 400 410 420
pF1KE2 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
110 120 130 140 150 160
430 440 450 460 470 480
pF1KE2 KILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
XP_005 KILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
170 180 190 200 210 220
490 500 510 520 530 540
pF1KE2 VLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLK
::::::::::::::::::::::::::.:::::::.:::.::::::::::: :::::::::
XP_005 VLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLK
230 240 250 260 270 280
550 560 570 580 590
pF1KE2 EQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR----TKDSKAF
:. ::::::: .:::::::::.::..: :.::. :.: .: : .. :: .
XP_005 EHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEM
290 300 310 320 330 340
600 610 620 630 640 650
pF1KE2 RQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEK
..::..: :: ...:.. ::::::::::.:::::::::.::..:::.:::::.. ::::
XP_005 KRMGFEDP-KD-KNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEK
350 360 370 380 390 400
660 670 680 690 700 710
pF1KE2 KYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYS
:::..:: ::::::::: ::: ::::.:. : ::: .::..: . ::: ..:.. ..::
XP_005 KYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYS
410 420 430 440 450 460
720 730 740 750 760 770
pF1KE2 CGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNL
: .:::. :: :::.::::. .:: ::.:.. ::: .:..:::::: . .: :. :.
XP_005 CVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNI
470 480 490 500 510 520
780 790 800 810 820 830
pF1KE2 TPADITACHLQQ--LNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIG
. ....:::. . .::::: . .: . :.:.::::: ..:::::: ::::.:: ::
XP_005 SASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIG
530 540 550 560 570 580
840 850 860 870 880
pF1KE2 KLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFD---------------
::...... ::: ::.. : .:.::: :::. .... :. .
XP_005 KLVLMLAIELIY-VLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEA
590 600 610 620 630 640
890 900 910 920 930
pF1KE2 GLDCPA---------AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGE
: :. : .:::: .::.:. ::.::::::::::::::::::::::::: :
XP_005 GTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEE
650 660 670 680 690 700
940 950 960 970 980 990
pF1KE2 KEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYV
710 720 730 740 750 760
1000 1010 1020 1030 1040 1050
pF1KE2 ELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGR
::::::::::::::::::::::::::::.:::::::::::::::::::::: ::::.::.
XP_005 ELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGK
770 780 790 800 810 820
1060 1070 1080 1090 1100 1110
pF1KE2 SHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNV
.:: ::::.::.::.:::.::::::::::::::::.::::::::::::::::::::::::
XP_005 THIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNV
830 840 850 860 870 880
1120 1130 1140 1150 1160
pF1KE2 SSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
.:::::::::::::::::.::::::. ::::::::::::::::: ::::::::
XP_005 ASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
890 900 910 920 930
>>XP_011510662 (OMIM: 600293,606703) PREDICTED: adenylat (923 aa)
initn: 4326 init1: 1764 opt: 2735 Z-score: 2863.4 bits: 541.5 E(85289): 9.3e-153
Smith-Waterman score: 4343; 73.6% identity (87.0% similar) in 910 aa overlap (287-1166:14-920)
260 270 280 290 300 310
pF1KE2 MRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQ
: : .:::.: :::..:.::::::::::::
XP_011 MLLIRLRDFPSIPKLLVSNVLIFSCTNIVGVCTHYPAEVSQRQ
10 20 30 40
320 330 340 350 360 370
pF1KE2 AFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHD
:::::: :::::: :.::.:::::::::::.::::::: :::.:.::::::::::::::
XP_011 AFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHD
50 60 70 80 90 100
380 390 400 410 420 430
pF1KE2 NVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGL
110 120 130 140 150 160
440 450 460 470 480 490
pF1KE2 PEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWS
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWS
170 180 190 200 210 220
500 510 520 530 540 550
pF1KE2 NDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGAS
:::::::::::::.:::::::.:::.::::::::::: ::::::::::. ::::::: .
XP_011 NDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCT
230 240 250 260 270 280
560 570 580 590 600 610
pF1KE2 QKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR----TKDSKAFRQMGIDDSSKDNR
:::::::::.::..: :.::. :.: .: : .. :: ...::..: :: .
XP_011 QKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDP-KD-K
290 300 310 320 330 340
620 630 640 650 660 670
pF1KE2 GTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAY
..:.. ::::::::::.:::::::::.::..:::.:::::.. :::::::..:: :::::
XP_011 NAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAY
350 360 370 380 390 400
680 690 700 710 720 730
pF1KE2 VACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLS
:::: ::: ::::.:. : ::: .::..: . ::: ..:.. ..::: .:::. :: ::
XP_011 VACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLS
410 420 430 440 450 460
740 750 760 770 780 790
pF1KE2 RSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQ-
:.::::. .:: ::.:.. ::: .:..:::::: . .: :. :.. ....:::. .
XP_011 RKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAES
470 480 490 500 510 520
800 810 820 830 840 850
pF1KE2 -LNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYL
.::::: . .: . :.:.::::: ..:::::: ::::.:: ::::...... :::
XP_011 AVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIY-
530 540 550 560 570 580
860 870 880
pF1KE2 VLLLLGPPATIFDNYDLLLGVHGLASSNETFD---------------GLDCPA-------
::.. : .:.::: :::. .... :. . : :.
XP_011 VLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSP
590 600 610 620 630 640
890 900 910 920 930 940
pF1KE2 --AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRR
: .:::: .::.:. ::.::::::::::::::::::::::::: ::::::::::::::
XP_011 EHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRR
650 660 670 680 690 700
950 960 970 980 990 1000
pF1KE2 LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR
710 720 730 740 750 760
1010 1020 1030 1040 1050 1060
pF1KE2 LLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRL
:::::::::::::::.:::::::::::::::::::::: ::::.::..:: ::::.::.:
XP_011 LLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKL
770 780 790 800 810 820
1070 1080 1090 1100 1110 1120
pF1KE2 MEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRI
:.:::.::::::::::::::::.::::::::::::::::::::::::.::::::::::::
XP_011 MDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRI
830 840 850 860 870 880
1130 1140 1150 1160
pF1KE2 QVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
:::::.::::::. ::::::::::::::::: ::::::::
XP_011 QVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
890 900 910 920
>>XP_011510661 (OMIM: 600293,606703) PREDICTED: adenylat (953 aa)
initn: 4322 init1: 1760 opt: 2735 Z-score: 2863.2 bits: 541.5 E(85289): 9.6e-153
Smith-Waterman score: 4343; 73.4% identity (86.8% similar) in 916 aa overlap (281-1166:41-950)
260 270 280 290 300 310
pF1KE2 TLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPA
: .: : : .:::.: :::..:.::::::
XP_011 THTLQTWSPLEKPVCTGQAEHGVEKEKPSGGRSF-W--LVSNVLIFSCTNIVGVCTHYPA
20 30 40 50 60
320 330 340 350 360 370
pF1KE2 EVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKI
:::::::::::: :::::: :.::.:::::::::::.::::::: :::.:.::::::::
XP_011 EVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKI
70 80 90 100 110 120
380 390 400 410 420 430
pF1KE2 YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCY
130 140 150 160 170 180
440 450 460 470 480 490
pF1KE2 YCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKW
:::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::
XP_011 YCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKW
190 200 210 220 230 240
500 510 520 530 540 550
pF1KE2 QFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETF
:::::::::::::::::::.:::::::.:::.::::::::::: ::::::::::. ::::
XP_011 QFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETF
250 260 270 280 290 300
560 570 580 590 600
pF1KE2 LILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR----TKDSKAFRQMGIDD
::: .:::::::::.::..: :.::. :.: .: : .. :: ...::..:
XP_011 LILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFED
310 320 330 340 350 360
610 620 630 640 650 660
pF1KE2 SSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVD
:: ...:.. ::::::::::.:::::::::.::..:::.:::::.. :::::::..::
XP_011 P-KD-KNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVD
370 380 390 400 410 420
670 680 690 700 710 720
pF1KE2 PRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPK
::::::::: ::: ::::.:. : ::: .::..: . ::: ..:.. ..::: .:::.
XP_011 DRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPS
430 440 450 460 470 480
730 740 750 760 770 780
pF1KE2 ALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITA
:: :::.::::. .:: ::.:.. ::: .:..:::::: . .: :. :.. ....:
XP_011 PLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNA
490 500 510 520 530 540
790 800 810 820 830 840
pF1KE2 CHLQQ--LNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFV
::. . .::::: . .: . :.:.::::: ..:::::: ::::.:: ::::.....
XP_011 CHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLA
550 560 570 580 590 600
850 860 870 880
pF1KE2 LGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFD---------------GLDCPA-
. ::: ::.. : .:.::: :::. .... :. . : :.
XP_011 IELIY-VLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSG
610 620 630 640 650 660
890 900 910 920 930 940
pF1KE2 --------AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEEL
: .:::: .::.:. ::.::::::::::::::::::::::::: ::::::::
XP_011 VKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEEL
670 680 690 700 710 720
950 960 970 980 990 1000
pF1KE2 QAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNE
730 740 750 760 770 780
1010 1020 1030 1040 1050 1060
pF1KE2 GVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALA
:::::::::::::::::::::.:::::::::::::::::::::: ::::.::..:: :::
XP_011 GVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALA
790 800 810 820 830 840
1070 1080 1090 1100 1110 1120
pF1KE2 DYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDST
:.::.::.:::.::::::::::::::::.::::::::::::::::::::::::.::::::
XP_011 DFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDST
850 860 870 880 890 900
1130 1140 1150 1160
pF1KE2 GVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
:::::::::::.::::::. ::::::::::::::::: ::::::::
XP_011 GVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
910 920 930 940 950
1168 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 16:28:55 2016 done: Tue Nov 8 16:28:57 2016
Total Scan time: 9.850 Total Display time: 0.390
Function used was FASTA [36.3.4 Apr, 2011]