FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3555, 5207 aa 1>>>pF1KE3555 5207 - 5207 aa - 5207 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.2406+/-0.000668; mu= 10.2016+/- 0.041 mean_var=225.7712+/-48.415, 0's: 0 Z-trim(110.3): 77 B-trim: 380 in 1/52 Lambda= 0.085357 statistics sampled from 18532 (18580) to 18532 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.544), E-opt: 0.2 (0.218), width: 16 Scan time: 34.070 The best scores are: opt bits E(85289) NP_001243000 (OMIM: 607151,613768) E3 ubiquitin-pr (5207) 34762 4297.5 0 XP_006722058 (OMIM: 607151,613768) PREDICTED: E3 u (5256) 34142 4221.1 0 XP_005257603 (OMIM: 607151,613768) PREDICTED: E3 u (5256) 34142 4221.1 0 XP_005257602 (OMIM: 607151,613768) PREDICTED: E3 u (5256) 34142 4221.1 0 XP_016880394 (OMIM: 607151,613768) PREDICTED: E3 u (4921) 32647 4037.0 0 XP_011523386 (OMIM: 607151,613768) PREDICTED: E3 u (4825) 31340 3876.1 0 XP_011523388 (OMIM: 607151,613768) PREDICTED: E3 u (4192) 27061 3349.1 0 XP_011523389 (OMIM: 607151,613768) PREDICTED: E3 u (3824) 24290 3007.8 0 NP_066005 (OMIM: 607151,613768) E3 ubiquitin-prote (1063) 6841 858.7 0 >>NP_001243000 (OMIM: 607151,613768) E3 ubiquitin-protei (5207 aa) initn: 34762 init1: 34762 opt: 34762 Z-score: 23137.5 bits: 4297.5 E(85289): 0 Smith-Waterman score: 34762; 99.9% identity (99.9% similar) in 5207 aa overlap (1-5207:1-5207) 10 20 30 40 50 60 pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LLLPESKGGSSEPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPP ::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::: NP_001 LLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 ATTPPFKTHCQEAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_001 ATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICEL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 HYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 FIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 LPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 DLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEH 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 LGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEAL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 SPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGD 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 MEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 DLRKFGIVLSAVITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLRKFGIVLSAVITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKR 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 LIAVADSVLTKVVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEKCAVEEAL ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: NP_001 LIAVADSVLTKVVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEAL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE3 DWRREELLLLKKEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTMTVRLS ::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::: NP_001 DWRREELLLLKKEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE3 TSSNSQRATHYHLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSSNSQRATHYHLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEP 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE3 EEESERHILELQEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSE :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEESERHILELEEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSE 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE3 LKIMCTVDHQGQRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLN :::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKIMCTVDHQDQRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLN 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE3 FTDNFDDFRRETLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FTDNFDDFRRETLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINE 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KE3 LKVFVDLASISAGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKVFVDLASISAGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALD 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KE3 KDQYLPRKLCDSARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDQYLPRKLCDSARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPD 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KE3 TVLHLILPESPGSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVLHLILPESPGSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLS 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KE3 QAFIDLHSAGNMLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QAFIDLHSAGNMLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQM 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KE3 EHFLDSWKRFVTQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EHFLDSWKRFVTQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRD 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 pF1KE3 VLRASVGCGSEAARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLRASVGCGSEAARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLE 1750 1760 1770 1780 1790 1800 1810 1820 1830 1840 1850 1860 pF1KE3 TLGHCLAHLAGMGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLGHCLAHLAGMGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYD 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 pF1KE3 EVLLCTPATTFEEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVLLCTPATTFEEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQH 1870 1880 1890 1900 1910 1920 1930 1940 1950 1960 1970 1980 pF1KE3 REDYQLVMVCDGDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REDYQLVMVCDGDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVF 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 pF1KE3 NDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALL 1990 2000 2010 2020 2030 2040 2050 2060 2070 2080 2090 2100 pF1KE3 PFLDAQYQKVPVLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PFLDAQYQKVPVLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEIL 2050 2060 2070 2080 2090 2100 2110 2120 2130 2140 2150 2160 pF1KE3 ERRTSVPSRSSSALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERRTSVPSRSSSALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFC 2110 2120 2130 2140 2150 2160 2170 2180 2190 2200 2210 2220 pF1KE3 SETFQRPYQYLRRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SETFQRPYQYLRRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFAR 2170 2180 2190 2200 2210 2220 2230 2240 2250 2260 2270 2280 pF1KE3 FLNYQLRDCEASLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLNYQLRDCEASLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVT 2230 2240 2250 2260 2270 2280 2290 2300 2310 2320 2330 2340 pF1KE3 MDGVREEDLAPFSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAINHLTGKV :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: NP_001 MDGVREEDLAPFSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKV 2290 2300 2310 2320 2330 2340 2350 2360 2370 2380 2390 2400 pF1KE3 IKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNM 2350 2360 2370 2380 2390 2400 2410 2420 2430 2440 2450 2460 pF1KE3 LKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMI 2410 2420 2430 2440 2450 2460 2470 2480 2490 2500 2510 2520 pF1KE3 YSRVREAENVAFANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YSRVREAENVAFANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHI 2470 2480 2490 2500 2510 2520 2530 2540 2550 2560 2570 2580 pF1KE3 IAACNPYRKHSEEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IAACNPYRKHSEEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVW 2530 2540 2550 2560 2570 2580 2590 2600 2610 2620 2630 2640 pF1KE3 DFGQLSDVAEKLYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFGQLSDVAEKLYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRD 2590 2600 2610 2620 2630 2640 2650 2660 2670 2680 2690 2700 pF1KE3 VERCVKVFRWFHEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VERCVKVFRWFHEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKK 2650 2660 2670 2680 2690 2700 2710 2720 2730 2740 2750 2760 pF1KE3 DSYRKAIARFFPKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSYRKAIARFFPKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIE 2710 2720 2730 2740 2750 2760 2770 2780 2790 2800 2810 2820 pF1KE3 LKIPLFLVGKPGSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKIPLFLVGKPGSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIIS 2770 2780 2790 2800 2810 2820 2830 2840 2850 2860 2870 2880 pF1KE3 TFRQCARFQQGKDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TFRQCARFQQGKDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVG 2830 2840 2850 2860 2870 2880 2890 2900 2910 2920 2930 2940 pF1KE3 FVGISNWALDPAKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FVGISNWALDPAKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYE 2890 2900 2910 2920 2930 2940 2950 2960 2970 2980 2990 3000 pF1KE3 TVCKRQDKEFFGLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVCKRQDKEFFGLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFL 2950 2960 2970 2980 2990 3000 3010 3020 3030 3040 3050 3060 pF1KE3 ANLPEAKCSEEVSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANLPEAKCSEEVSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFF 3010 3020 3030 3040 3050 3060 3070 3080 3090 3100 3110 3120 pF1KE3 EGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYY 3070 3080 3090 3100 3110 3120 3130 3140 3150 3160 3170 3180 pF1KE3 VHLGGQKYVDLGLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHLGGQKYVDLGLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVL 3130 3140 3150 3160 3170 3180 3190 3200 3210 3220 3230 3240 pF1KE3 EKWQKSIVEELCAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKWQKSIVEELCAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPR 3190 3200 3210 3220 3230 3240 3250 3260 3270 3280 3290 3300 pF1KE3 ALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFL 3250 3260 3270 3280 3290 3300 3310 3320 3330 3340 3350 3360 pF1KE3 QAHLHTADLERHAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QAHLHTADLERHAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLK 3310 3320 3330 3340 3350 3360 3370 3380 3390 3400 3410 3420 pF1KE3 EVRNCLTNTAKCKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVRNCLTNTAKCKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKL 3370 3380 3390 3400 3410 3420 3430 3440 3450 3460 3470 3480 pF1KE3 SRVGRGTAYVGFHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRVGRGTAYVGFHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHR 3430 3440 3450 3460 3470 3480 3490 3500 3510 3520 3530 3540 pF1KE3 AEDGHEEAMETEASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEDGHEEAMETEASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCV 3490 3500 3510 3520 3530 3540 3550 3560 3570 3580 3590 3600 pF1KE3 QSAVGMLRDQNESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSAVGMLRDQNESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHP 3550 3560 3570 3580 3590 3600 3610 3620 3630 3640 3650 3660 pF1KE3 LEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPW 3610 3620 3630 3640 3650 3660 3670 3680 3690 3700 3710 3720 pF1KE3 ARDLWMFIFSDTMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARDLWMFIFSDTMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLE 3670 3680 3690 3700 3710 3720 3730 3740 3750 3760 3770 3780 pF1KE3 ELWVQAQYITDAEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELWVQAQYITDAEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVST 3730 3740 3750 3760 3770 3780 3790 3800 3810 3820 3830 3840 pF1KE3 EEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLH 3790 3800 3810 3820 3830 3840 3850 3860 3870 3880 3890 3900 pF1KE3 SLMEARWNHELAGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLMEARWNHELAGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDE 3850 3860 3870 3880 3890 3900 3910 3920 3930 3940 3950 3960 pF1KE3 HMQGSGSLAQAVIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HMQGSGSLAQAVIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLR 3910 3920 3930 3940 3950 3960 3970 3980 3990 4000 4010 4020 pF1KE3 ENSDVKTHGPFEAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENSDVKTHGPFEAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRC 3970 3980 3990 4000 4010 4020 4030 4040 4050 4060 4070 4080 pF1KE3 LRAWFASEQMICPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRAWFASEQMICPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKD 4030 4040 4050 4060 4070 4080 4090 4100 4110 4120 4130 4140 pF1KE3 NAPPEKEVIESLLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NAPPEKEVIESLLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLK 4090 4100 4110 4120 4130 4140 4150 4160 4170 4180 4190 4200 pF1KE3 YSFHDVKDYIQEYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YSFHDVKDYIQEYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEE 4150 4160 4170 4180 4190 4200 4210 4220 4230 4240 4250 4260 pF1KE3 EGRFLKAYSPASRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGRFLKAYSPASRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYL 4210 4220 4230 4240 4250 4260 4270 4280 4290 4300 4310 4320 pF1KE3 QQVKQFCIRVENDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQVKQFCIRVENDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDH 4270 4280 4290 4300 4310 4320 4330 4340 4350 4360 4370 4380 pF1KE3 PGQMDRYLVYGDEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGQMDRYLVYGDEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVA 4330 4340 4350 4360 4370 4380 4390 4400 4410 4420 4430 4440 pF1KE3 ILYRSHNASLHPTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILYRSHNASLHPTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLD 4390 4400 4410 4420 4430 4440 4450 4460 4470 4480 4490 4500 pF1KE3 GTVTEMAIHAAAVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTVTEMAIHAAAVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERV 4450 4460 4470 4480 4490 4500 4510 4520 4530 4540 4550 4560 pF1KE3 HWYTCPNGHPCSVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HWYTCPNGHPCSVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLG 4510 4520 4530 4540 4550 4560 4570 4580 4590 4600 4610 4620 pF1KE3 NPQRRDVVTCDRGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPQRRDVVTCDRGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHI 4570 4580 4590 4600 4610 4620 4630 4640 4650 4660 4670 4680 pF1KE3 LKDLEQLAKMLGHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKDLEQLAKMLGHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKE 4630 4640 4650 4660 4670 4680 4690 4700 4710 4720 4730 4740 pF1KE3 IAAVISPELEHLDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IAAVISPELEHLDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKI 4690 4700 4710 4720 4730 4740 4750 4760 4770 4780 4790 4800 pF1KE3 WSCRKRITVEYLQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WSCRKRITVEYLQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQN 4750 4760 4770 4780 4790 4800 4810 4820 4830 4840 4850 4860 pF1KE3 VQQVEYSSIRGFLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQQVEYSSIRGFLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDL 4810 4820 4830 4840 4850 4860 4870 4880 4890 4900 4910 4920 pF1KE3 DLDTEFEILLPRRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLDTEFEILLPRRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHV 4870 4880 4890 4900 4910 4920 4930 4940 4950 4960 4970 4980 pF1KE3 ISYEVERDLTPLILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISYEVERDLTPLILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLV 4930 4940 4950 4960 4970 4980 4990 5000 5010 5020 5030 5040 pF1KE3 YRHDWNYEHLFMDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YRHDWNYEHLFMDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGG 4990 5000 5010 5020 5030 5040 5050 5060 5070 5080 5090 5100 pF1KE3 DPNMQLNVYTQDILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPNMQLNVYTQDILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGE 5050 5060 5070 5080 5090 5100 5110 5120 5130 5140 5150 5160 pF1KE3 ISSRYKADLSPENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISSRYKADLSPENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRD 5110 5120 5130 5140 5150 5160 5170 5180 5190 5200 pF1KE3 TLVSYMQTKESEILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLVSYMQTKESEILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR 5170 5180 5190 5200 >>XP_006722058 (OMIM: 607151,613768) PREDICTED: E3 ubiqu (5256 aa) initn: 34130 init1: 34130 opt: 34142 Z-score: 22724.8 bits: 4221.1 E(85289): 0 Smith-Waterman score: 34526; 98.9% identity (99.0% similar) in 5239 aa overlap (18-5207:18-5256) 10 20 30 40 50 60 pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG ::::::::::::::::::::::::::::::::::::::::::: XP_006 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG 10 20 30 40 50 60 70 80 pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQE--------------------------------- ::::::::::::::::::::::::::: XP_006 PCLFPGSDSWQENPEEPCSKASWTVQEGATSEVLVDAAVDLISDEWEAANAIPSKRRKQD 70 80 90 100 110 120 90 100 110 120 130 pF1KE3 ----------------SKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT :::::::::::::::::::::::::::::::::::::::::::: XP_006 AAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE3 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE3 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE3 EPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_006 EPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE3 EAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE3 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV 430 440 450 460 470 480 440 450 460 470 480 490 pF1KE3 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE3 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS 550 560 570 580 590 600 560 570 580 590 600 610 pF1KE3 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP 610 620 630 640 650 660 620 630 640 650 660 670 pF1KE3 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS 670 680 690 700 710 720 680 690 700 710 720 730 pF1KE3 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR 730 740 750 760 770 780 740 750 760 770 780 790 pF1KE3 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC 790 800 810 820 830 840 800 810 820 830 840 850 pF1KE3 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL 850 860 870 880 890 900 860 870 880 890 900 910 pF1KE3 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK 910 920 930 940 950 960 920 930 940 950 960 970 pF1KE3 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL 970 980 990 1000 1010 1020 980 990 1000 1010 1020 1030 pF1KE3 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA 1030 1040 1050 1060 1070 1080 1040 1050 1060 1070 1080 1090 pF1KE3 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK 1090 1100 1110 1120 1130 1140 1100 1110 1120 1130 1140 1150 pF1KE3 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEKCAVEEALDWRREELLLLK :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: XP_006 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEALDWRREELLLLK 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 1210 pF1KE3 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTMTVRLSTSSNSQRATHY :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: XP_006 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHY 1210 1220 1230 1240 1250 1260 1220 1230 1240 1250 1260 1270 pF1KE3 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KE3 QEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQG .:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQD 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 1380 1390 pF1KE3 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE 1390 1400 1410 1420 1430 1440 1400 1410 1420 1430 1440 1450 pF1KE3 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS 1450 1460 1470 1480 1490 1500 1460 1470 1480 1490 1500 1510 pF1KE3 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD 1510 1520 1530 1540 1550 1560 1520 1530 1540 1550 1560 1570 pF1KE3 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP 1570 1580 1590 1600 1610 1620 1580 1590 1600 1610 1620 1630 pF1KE3 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN 1630 1640 1650 1660 1670 1680 1640 1650 1660 1670 1680 1690 pF1KE3 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV 1690 1700 1710 1720 1730 1740 1700 1710 1720 1730 1740 1750 pF1KE3 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE 1750 1760 1770 1780 1790 1800 1760 1770 1780 1790 1800 1810 pF1KE3 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG 1810 1820 1830 1840 1850 1860 1820 1830 1840 1850 1860 1870 pF1KE3 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF 1870 1880 1890 1900 1910 1920 1880 1890 1900 1910 1920 1930 pF1KE3 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD 1930 1940 1950 1960 1970 1980 1940 1950 1960 1970 1980 1990 pF1KE3 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS 1990 2000 2010 2020 2030 2040 2000 2010 2020 2030 2040 2050 pF1KE3 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP 2050 2060 2070 2080 2090 2100 2060 2070 2080 2090 2100 2110 pF1KE3 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS 2110 2120 2130 2140 2150 2160 2120 2130 2140 2150 2160 2170 pF1KE3 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL 2170 2180 2190 2200 2210 2220 2180 2190 2200 2210 2220 2230 pF1KE3 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA 2230 2240 2250 2260 2270 2280 2240 2250 2260 2270 2280 2290 pF1KE3 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP 2290 2300 2310 2320 2330 2340 2300 2310 2320 2330 2340 2350 pF1KE3 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAINHLTGKVIKRDVMTRDLY ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: XP_006 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLY 2350 2360 2370 2380 2390 2400 2360 2370 2380 2390 2400 2410 pF1KE3 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR 2410 2420 2430 2440 2450 2460 2420 2430 2440 2450 2460 2470 pF1KE3 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA 2470 2480 2490 2500 2510 2520 2480 2490 2500 2510 2520 2530 pF1KE3 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS 2530 2540 2550 2560 2570 2580 2540 2550 2560 2570 2580 2590 pF1KE3 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK 2590 2600 2610 2620 2630 2640 2600 2610 2620 2630 2640 2650 pF1KE3 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF 2650 2660 2670 2680 2690 2700 2660 2670 2680 2690 2700 2710 pF1KE3 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF 2710 2720 2730 2740 2750 2760 2720 2730 2740 2750 2760 2770 pF1KE3 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP 2770 2780 2790 2800 2810 2820 2780 2790 2800 2810 2820 2830 pF1KE3 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG 2830 2840 2850 2860 2870 2880 2840 2850 2860 2870 2880 2890 pF1KE3 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP 2890 2900 2910 2920 2930 2940 2900 2910 2920 2930 2940 2950 pF1KE3 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF 2950 2960 2970 2980 2990 3000 2960 2970 2980 2990 3000 3010 pF1KE3 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE 3010 3020 3030 3040 3050 3060 3020 3030 3040 3050 3060 3070 pF1KE3 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG 3070 3080 3090 3100 3110 3120 3080 3090 3100 3110 3120 3130 pF1KE3 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL 3130 3140 3150 3160 3170 3180 3140 3150 3160 3170 3180 3190 pF1KE3 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL 3190 3200 3210 3220 3230 3240 3200 3210 3220 3230 3240 3250 pF1KE3 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS 3250 3260 3270 3280 3290 3300 3260 3270 3280 3290 3300 3310 pF1KE3 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER 3310 3320 3330 3340 3350 3360 3320 3330 3340 3350 3360 3370 pF1KE3 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK 3370 3380 3390 3400 3410 3420 3380 3390 3400 3410 3420 3430 pF1KE3 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG 3430 3440 3450 3460 3470 3480 3440 3450 3460 3470 3480 3490 pF1KE3 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET 3490 3500 3510 3520 3530 3540 3500 3510 3520 3530 3540 3550 pF1KE3 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN 3550 3560 3570 3580 3590 3600 3560 3570 3580 3590 3600 3610 pF1KE3 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ 3610 3620 3630 3640 3650 3660 3620 3630 3640 3650 3660 3670 pF1KE3 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD 3670 3680 3690 3700 3710 3720 3680 3690 3700 3710 3720 3730 pF1KE3 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD 3730 3740 3750 3760 3770 3780 3740 3750 3760 3770 3780 3790 pF1KE3 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL 3790 3800 3810 3820 3830 3840 3800 3810 3820 3830 3840 3850 pF1KE3 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL 3850 3860 3870 3880 3890 3900 3860 3870 3880 3890 3900 3910 pF1KE3 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA 3910 3920 3930 3940 3950 3960 3920 3930 3940 3950 3960 3970 pF1KE3 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF 3970 3980 3990 4000 4010 4020 3980 3990 4000 4010 4020 4030 pF1KE3 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI 4030 4040 4050 4060 4070 4080 4040 4050 4060 4070 4080 4090 pF1KE3 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES 4090 4100 4110 4120 4130 4140 4100 4110 4120 4130 4140 4150 pF1KE3 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ 4150 4160 4170 4180 4190 4200 4160 4170 4180 4190 4200 4210 pF1KE3 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA 4210 4220 4230 4240 4250 4260 4220 4230 4240 4250 4260 4270 pF1KE3 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE 4270 4280 4290 4300 4310 4320 4280 4290 4300 4310 4320 4330 pF1KE3 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG 4330 4340 4350 4360 4370 4380 4340 4350 4360 4370 4380 4390 pF1KE3 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH 4390 4400 4410 4420 4430 4440 4400 4410 4420 4430 4440 4450 pF1KE3 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA 4450 4460 4470 4480 4490 4500 4460 4470 4480 4490 4500 4510 pF1KE3 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC 4510 4520 4530 4540 4550 4560 4520 4530 4540 4550 4560 4570 pF1KE3 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD 4570 4580 4590 4600 4610 4620 4580 4590 4600 4610 4620 4630 pF1KE3 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML 4630 4640 4650 4660 4670 4680 4640 4650 4660 4670 4680 4690 pF1KE3 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH 4690 4700 4710 4720 4730 4740 4700 4710 4720 4730 4740 4750 pF1KE3 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY 4750 4760 4770 4780 4790 4800 4760 4770 4780 4790 4800 4810 pF1KE3 LQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRG 4810 4820 4830 4840 4850 4860 4820 4830 4840 4850 4860 4870 pF1KE3 FLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLP 4870 4880 4890 4900 4910 4920 4880 4890 4900 4910 4920 4930 pF1KE3 RRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHVISYEVERDLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHVISYEVERDLTP 4930 4940 4950 4960 4970 4980 4940 4950 4960 4970 4980 4990 pF1KE3 LILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLF 4990 5000 5010 5020 5030 5040 5000 5010 5020 5030 5040 5050 pF1KE3 MDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQ 5050 5060 5070 5080 5090 5100 5060 5070 5080 5090 5100 5110 pF1KE3 DILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSP 5110 5120 5130 5140 5150 5160 5120 5130 5140 5150 5160 5170 pF1KE3 ENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKES 5170 5180 5190 5200 5210 5220 5180 5190 5200 pF1KE3 EILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR :::::::::::::::::::::::::::::::::::: XP_006 EILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR 5230 5240 5250 >>XP_005257603 (OMIM: 607151,613768) PREDICTED: E3 ubiqu (5256 aa) initn: 34130 init1: 34130 opt: 34142 Z-score: 22724.8 bits: 4221.1 E(85289): 0 Smith-Waterman score: 34526; 98.9% identity (99.0% similar) in 5239 aa overlap (18-5207:18-5256) 10 20 30 40 50 60 pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG ::::::::::::::::::::::::::::::::::::::::::: XP_005 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG 10 20 30 40 50 60 70 80 pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQE--------------------------------- ::::::::::::::::::::::::::: XP_005 PCLFPGSDSWQENPEEPCSKASWTVQEGATSEVLVDAAVDLISDEWEAANAIPSKRRKQD 70 80 90 100 110 120 90 100 110 120 130 pF1KE3 ----------------SKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT :::::::::::::::::::::::::::::::::::::::::::: XP_005 AAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE3 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE3 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE3 EPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_005 EPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE3 EAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE3 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV 430 440 450 460 470 480 440 450 460 470 480 490 pF1KE3 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE3 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS 550 560 570 580 590 600 560 570 580 590 600 610 pF1KE3 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP 610 620 630 640 650 660 620 630 640 650 660 670 pF1KE3 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS 670 680 690 700 710 720 680 690 700 710 720 730 pF1KE3 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR 730 740 750 760 770 780 740 750 760 770 780 790 pF1KE3 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC 790 800 810 820 830 840 800 810 820 830 840 850 pF1KE3 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL 850 860 870 880 890 900 860 870 880 890 900 910 pF1KE3 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK 910 920 930 940 950 960 920 930 940 950 960 970 pF1KE3 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL 970 980 990 1000 1010 1020 980 990 1000 1010 1020 1030 pF1KE3 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA 1030 1040 1050 1060 1070 1080 1040 1050 1060 1070 1080 1090 pF1KE3 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK 1090 1100 1110 1120 1130 1140 1100 1110 1120 1130 1140 1150 pF1KE3 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEKCAVEEALDWRREELLLLK :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: XP_005 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEALDWRREELLLLK 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 1210 pF1KE3 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTMTVRLSTSSNSQRATHY :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: XP_005 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHY 1210 1220 1230 1240 1250 1260 1220 1230 1240 1250 1260 1270 pF1KE3 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KE3 QEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQG .:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQD 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 1380 1390 pF1KE3 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE 1390 1400 1410 1420 1430 1440 1400 1410 1420 1430 1440 1450 pF1KE3 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS 1450 1460 1470 1480 1490 1500 1460 1470 1480 1490 1500 1510 pF1KE3 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD 1510 1520 1530 1540 1550 1560 1520 1530 1540 1550 1560 1570 pF1KE3 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP 1570 1580 1590 1600 1610 1620 1580 1590 1600 1610 1620 1630 pF1KE3 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN 1630 1640 1650 1660 1670 1680 1640 1650 1660 1670 1680 1690 pF1KE3 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV 1690 1700 1710 1720 1730 1740 1700 1710 1720 1730 1740 1750 pF1KE3 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE 1750 1760 1770 1780 1790 1800 1760 1770 1780 1790 1800 1810 pF1KE3 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG 1810 1820 1830 1840 1850 1860 1820 1830 1840 1850 1860 1870 pF1KE3 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF 1870 1880 1890 1900 1910 1920 1880 1890 1900 1910 1920 1930 pF1KE3 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD 1930 1940 1950 1960 1970 1980 1940 1950 1960 1970 1980 1990 pF1KE3 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS 1990 2000 2010 2020 2030 2040 2000 2010 2020 2030 2040 2050 pF1KE3 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP 2050 2060 2070 2080 2090 2100 2060 2070 2080 2090 2100 2110 pF1KE3 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS 2110 2120 2130 2140 2150 2160 2120 2130 2140 2150 2160 2170 pF1KE3 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL 2170 2180 2190 2200 2210 2220 2180 2190 2200 2210 2220 2230 pF1KE3 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA 2230 2240 2250 2260 2270 2280 2240 2250 2260 2270 2280 2290 pF1KE3 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP 2290 2300 2310 2320 2330 2340 2300 2310 2320 2330 2340 2350 pF1KE3 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAINHLTGKVIKRDVMTRDLY ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: XP_005 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLY 2350 2360 2370 2380 2390 2400 2360 2370 2380 2390 2400 2410 pF1KE3 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR 2410 2420 2430 2440 2450 2460 2420 2430 2440 2450 2460 2470 pF1KE3 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA 2470 2480 2490 2500 2510 2520 2480 2490 2500 2510 2520 2530 pF1KE3 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS 2530 2540 2550 2560 2570 2580 2540 2550 2560 2570 2580 2590 pF1KE3 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK 2590 2600 2610 2620 2630 2640 2600 2610 2620 2630 2640 2650 pF1KE3 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF 2650 2660 2670 2680 2690 2700 2660 2670 2680 2690 2700 2710 pF1KE3 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF 2710 2720 2730 2740 2750 2760 2720 2730 2740 2750 2760 2770 pF1KE3 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP 2770 2780 2790 2800 2810 2820 2780 2790 2800 2810 2820 2830 pF1KE3 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG 2830 2840 2850 2860 2870 2880 2840 2850 2860 2870 2880 2890 pF1KE3 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP 2890 2900 2910 2920 2930 2940 2900 2910 2920 2930 2940 2950 pF1KE3 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF 2950 2960 2970 2980 2990 3000 2960 2970 2980 2990 3000 3010 pF1KE3 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE 3010 3020 3030 3040 3050 3060 3020 3030 3040 3050 3060 3070 pF1KE3 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG 3070 3080 3090 3100 3110 3120 3080 3090 3100 3110 3120 3130 pF1KE3 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL 3130 3140 3150 3160 3170 3180 3140 3150 3160 3170 3180 3190 pF1KE3 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL 3190 3200 3210 3220 3230 3240 3200 3210 3220 3230 3240 3250 pF1KE3 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS 3250 3260 3270 3280 3290 3300 3260 3270 3280 3290 3300 3310 pF1KE3 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER 3310 3320 3330 3340 3350 3360 3320 3330 3340 3350 3360 3370 pF1KE3 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK 3370 3380 3390 3400 3410 3420 3380 3390 3400 3410 3420 3430 pF1KE3 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG 3430 3440 3450 3460 3470 3480 3440 3450 3460 3470 3480 3490 pF1KE3 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET 3490 3500 3510 3520 3530 3540 3500 3510 3520 3530 3540 3550 pF1KE3 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN 3550 3560 3570 3580 3590 3600 3560 3570 3580 3590 3600 3610 pF1KE3 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ 3610 3620 3630 3640 3650 3660 3620 3630 3640 3650 3660 3670 pF1KE3 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD 3670 3680 3690 3700 3710 3720 3680 3690 3700 3710 3720 3730 pF1KE3 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD 3730 3740 3750 3760 3770 3780 3740 3750 3760 3770 3780 3790 pF1KE3 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL 3790 3800 3810 3820 3830 3840 3800 3810 3820 3830 3840 3850 pF1KE3 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL 3850 3860 3870 3880 3890 3900 3860 3870 3880 3890 3900 3910 pF1KE3 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA 3910 3920 3930 3940 3950 3960 3920 3930 3940 3950 3960 3970 pF1KE3 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF 3970 3980 3990 4000 4010 4020 3980 3990 4000 4010 4020 4030 pF1KE3 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI 4030 4040 4050 4060 4070 4080 4040 4050 4060 4070 4080 4090 pF1KE3 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES 4090 4100 4110 4120 4130 4140 4100 4110 4120 4130 4140 4150 pF1KE3 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ 4150 4160 4170 4180 4190 4200 4160 4170 4180 4190 4200 4210 pF1KE3 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA 4210 4220 4230 4240 4250 4260 4220 4230 4240 4250 4260 4270 pF1KE3 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE 4270 4280 4290 4300 4310 4320 4280 4290 4300 4310 4320 4330 pF1KE3 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG 4330 4340 4350 4360 4370 4380 4340 4350 4360 4370 4380 4390 pF1KE3 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH 4390 4400 4410 4420 4430 4440 4400 4410 4420 4430 4440 4450 pF1KE3 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA 4450 4460 4470 4480 4490 4500 4460 4470 4480 4490 4500 4510 pF1KE3 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC 4510 4520 4530 4540 4550 4560 4520 4530 4540 4550 4560 4570 pF1KE3 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD 4570 4580 4590 4600 4610 4620 4580 4590 4600 4610 4620 4630 pF1KE3 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML 4630 4640 4650 4660 4670 4680 4640 4650 4660 4670 4680 4690 pF1KE3 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH 4690 4700 4710 4720 4730 4740 4700 4710 4720 4730 4740 4750 pF1KE3 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY 4750 4760 4770 4780 4790 4800 4760 4770 4780 4790 4800 4810 pF1KE3 LQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRG 4810 4820 4830 4840 4850 4860 4820 4830 4840 4850 4860 4870 pF1KE3 FLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLP 4870 4880 4890 4900 4910 4920 4880 4890 4900 4910 4920 4930 pF1KE3 RRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHVISYEVERDLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHVISYEVERDLTP 4930 4940 4950 4960 4970 4980 4940 4950 4960 4970 4980 4990 pF1KE3 LILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLF 4990 5000 5010 5020 5030 5040 5000 5010 5020 5030 5040 5050 pF1KE3 MDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQ 5050 5060 5070 5080 5090 5100 5060 5070 5080 5090 5100 5110 pF1KE3 DILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSP 5110 5120 5130 5140 5150 5160 5120 5130 5140 5150 5160 5170 pF1KE3 ENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKES 5170 5180 5190 5200 5210 5220 5180 5190 5200 pF1KE3 EILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR :::::::::::::::::::::::::::::::::::: XP_005 EILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR 5230 5240 5250 >>XP_005257602 (OMIM: 607151,613768) PREDICTED: E3 ubiqu (5256 aa) initn: 34130 init1: 34130 opt: 34142 Z-score: 22724.8 bits: 4221.1 E(85289): 0 Smith-Waterman score: 34526; 98.9% identity (99.0% similar) in 5239 aa overlap (18-5207:18-5256) 10 20 30 40 50 60 pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG ::::::::::::::::::::::::::::::::::::::::::: XP_005 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG 10 20 30 40 50 60 70 80 pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQE--------------------------------- ::::::::::::::::::::::::::: XP_005 PCLFPGSDSWQENPEEPCSKASWTVQEGATSEVLVDAAVDLISDEWEAANAIPSKRRKQD 70 80 90 100 110 120 90 100 110 120 130 pF1KE3 ----------------SKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT :::::::::::::::::::::::::::::::::::::::::::: XP_005 AAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE3 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE3 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE3 EPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_005 EPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE3 EAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE3 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV 430 440 450 460 470 480 440 450 460 470 480 490 pF1KE3 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE3 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS 550 560 570 580 590 600 560 570 580 590 600 610 pF1KE3 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP 610 620 630 640 650 660 620 630 640 650 660 670 pF1KE3 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS 670 680 690 700 710 720 680 690 700 710 720 730 pF1KE3 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR 730 740 750 760 770 780 740 750 760 770 780 790 pF1KE3 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC 790 800 810 820 830 840 800 810 820 830 840 850 pF1KE3 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL 850 860 870 880 890 900 860 870 880 890 900 910 pF1KE3 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK 910 920 930 940 950 960 920 930 940 950 960 970 pF1KE3 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL 970 980 990 1000 1010 1020 980 990 1000 1010 1020 1030 pF1KE3 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA 1030 1040 1050 1060 1070 1080 1040 1050 1060 1070 1080 1090 pF1KE3 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK 1090 1100 1110 1120 1130 1140 1100 1110 1120 1130 1140 1150 pF1KE3 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEKCAVEEALDWRREELLLLK :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: XP_005 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEALDWRREELLLLK 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 1210 pF1KE3 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTMTVRLSTSSNSQRATHY :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: XP_005 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHY 1210 1220 1230 1240 1250 1260 1220 1230 1240 1250 1260 1270 pF1KE3 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KE3 QEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQG .:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQD 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 1380 1390 pF1KE3 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE 1390 1400 1410 1420 1430 1440 1400 1410 1420 1430 1440 1450 pF1KE3 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS 1450 1460 1470 1480 1490 1500 1460 1470 1480 1490 1500 1510 pF1KE3 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD 1510 1520 1530 1540 1550 1560 1520 1530 1540 1550 1560 1570 pF1KE3 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP 1570 1580 1590 1600 1610 1620 1580 1590 1600 1610 1620 1630 pF1KE3 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN 1630 1640 1650 1660 1670 1680 1640 1650 1660 1670 1680 1690 pF1KE3 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV 1690 1700 1710 1720 1730 1740 1700 1710 1720 1730 1740 1750 pF1KE3 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE 1750 1760 1770 1780 1790 1800 1760 1770 1780 1790 1800 1810 pF1KE3 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG 1810 1820 1830 1840 1850 1860 1820 1830 1840 1850 1860 1870 pF1KE3 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF 1870 1880 1890 1900 1910 1920 1880 1890 1900 1910 1920 1930 pF1KE3 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD 1930 1940 1950 1960 1970 1980 1940 1950 1960 1970 1980 1990 pF1KE3 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS 1990 2000 2010 2020 2030 2040 2000 2010 2020 2030 2040 2050 pF1KE3 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP 2050 2060 2070 2080 2090 2100 2060 2070 2080 2090 2100 2110 pF1KE3 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS 2110 2120 2130 2140 2150 2160 2120 2130 2140 2150 2160 2170 pF1KE3 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL 2170 2180 2190 2200 2210 2220 2180 2190 2200 2210 2220 2230 pF1KE3 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA 2230 2240 2250 2260 2270 2280 2240 2250 2260 2270 2280 2290 pF1KE3 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP 2290 2300 2310 2320 2330 2340 2300 2310 2320 2330 2340 2350 pF1KE3 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAINHLTGKVIKRDVMTRDLY ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: XP_005 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLY 2350 2360 2370 2380 2390 2400 2360 2370 2380 2390 2400 2410 pF1KE3 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR 2410 2420 2430 2440 2450 2460 2420 2430 2440 2450 2460 2470 pF1KE3 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA 2470 2480 2490 2500 2510 2520 2480 2490 2500 2510 2520 2530 pF1KE3 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS 2530 2540 2550 2560 2570 2580 2540 2550 2560 2570 2580 2590 pF1KE3 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK 2590 2600 2610 2620 2630 2640 2600 2610 2620 2630 2640 2650 pF1KE3 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF 2650 2660 2670 2680 2690 2700 2660 2670 2680 2690 2700 2710 pF1KE3 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF 2710 2720 2730 2740 2750 2760 2720 2730 2740 2750 2760 2770 pF1KE3 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP 2770 2780 2790 2800 2810 2820 2780 2790 2800 2810 2820 2830 pF1KE3 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG 2830 2840 2850 2860 2870 2880 2840 2850 2860 2870 2880 2890 pF1KE3 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP 2890 2900 2910 2920 2930 2940 2900 2910 2920 2930 2940 2950 pF1KE3 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF 2950 2960 2970 2980 2990 3000 2960 2970 2980 2990 3000 3010 pF1KE3 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE 3010 3020 3030 3040 3050 3060 3020 3030 3040 3050 3060 3070 pF1KE3 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG 3070 3080 3090 3100 3110 3120 3080 3090 3100 3110 3120 3130 pF1KE3 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL 3130 3140 3150 3160 3170 3180 3140 3150 3160 3170 3180 3190 pF1KE3 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL 3190 3200 3210 3220 3230 3240 3200 3210 3220 3230 3240 3250 pF1KE3 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS 3250 3260 3270 3280 3290 3300 3260 3270 3280 3290 3300 3310 pF1KE3 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER 3310 3320 3330 3340 3350 3360 3320 3330 3340 3350 3360 3370 pF1KE3 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK 3370 3380 3390 3400 3410 3420 3380 3390 3400 3410 3420 3430 pF1KE3 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG 3430 3440 3450 3460 3470 3480 3440 3450 3460 3470 3480 3490 pF1KE3 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET 3490 3500 3510 3520 3530 3540 3500 3510 3520 3530 3540 3550 pF1KE3 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN 3550 3560 3570 3580 3590 3600 3560 3570 3580 3590 3600 3610 pF1KE3 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ 3610 3620 3630 3640 3650 3660 3620 3630 3640 3650 3660 3670 pF1KE3 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD 3670 3680 3690 3700 3710 3720 3680 3690 3700 3710 3720 3730 pF1KE3 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD 3730 3740 3750 3760 3770 3780 3740 3750 3760 3770 3780 3790 pF1KE3 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL 3790 3800 3810 3820 3830 3840 3800 3810 3820 3830 3840 3850 pF1KE3 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL 3850 3860 3870 3880 3890 3900 3860 3870 3880 3890 3900 3910 pF1KE3 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA 3910 3920 3930 3940 3950 3960 3920 3930 3940 3950 3960 3970 pF1KE3 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF 3970 3980 3990 4000 4010 4020 3980 3990 4000 4010 4020 4030 pF1KE3 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI 4030 4040 4050 4060 4070 4080 4040 4050 4060 4070 4080 4090 pF1KE3 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES 4090 4100 4110 4120 4130 4140 4100 4110 4120 4130 4140 4150 pF1KE3 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ 4150 4160 4170 4180 4190 4200 4160 4170 4180 4190 4200 4210 pF1KE3 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA 4210 4220 4230 4240 4250 4260 4220 4230 4240 4250 4260 4270 pF1KE3 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE 4270 4280 4290 4300 4310 4320 4280 4290 4300 4310 4320 4330 pF1KE3 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG 4330 4340 4350 4360 4370 4380 4340 4350 4360 4370 4380 4390 pF1KE3 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH 4390 4400 4410 4420 4430 4440 4400 4410 4420 4430 4440 4450 pF1KE3 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA 4450 4460 4470 4480 4490 4500 4460 4470 4480 4490 4500 4510 pF1KE3 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC 4510 4520 4530 4540 4550 4560 4520 4530 4540 4550 4560 4570 pF1KE3 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD 4570 4580 4590 4600 4610 4620 4580 4590 4600 4610 4620 4630 pF1KE3 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML 4630 4640 4650 4660 4670 4680 4640 4650 4660 4670 4680 4690 pF1KE3 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH 4690 4700 4710 4720 4730 4740 4700 4710 4720 4730 4740 4750 pF1KE3 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY 4750 4760 4770 4780 4790 4800 4760 4770 4780 4790 4800 4810 pF1KE3 LQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRG 4810 4820 4830 4840 4850 4860 4820 4830 4840 4850 4860 4870 pF1KE3 FLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLP 4870 4880 4890 4900 4910 4920 4880 4890 4900 4910 4920 4930 pF1KE3 RRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHVISYEVERDLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHVISYEVERDLTP 4930 4940 4950 4960 4970 4980 4940 4950 4960 4970 4980 4990 pF1KE3 LILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLF 4990 5000 5010 5020 5030 5040 5000 5010 5020 5030 5040 5050 pF1KE3 MDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQ 5050 5060 5070 5080 5090 5100 5060 5070 5080 5090 5100 5110 pF1KE3 DILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSP 5110 5120 5130 5140 5150 5160 5120 5130 5140 5150 5160 5170 pF1KE3 ENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKES 5170 5180 5190 5200 5210 5220 5180 5190 5200 pF1KE3 EILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR :::::::::::::::::::::::::::::::::::: XP_005 EILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR 5230 5240 5250 >>XP_016880394 (OMIM: 607151,613768) PREDICTED: E3 ubiqu (4921 aa) initn: 32646 init1: 32646 opt: 32647 Z-score: 21730.3 bits: 4037.0 E(85289): 0 Smith-Waterman score: 32647; 99.8% identity (99.9% similar) in 4901 aa overlap (307-5207:21-4921) 280 290 300 310 320 330 pF1KE3 EPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDETAAAEEKVGKNEQGEP : ::::::::: ::::::::::::::: XP_016 MIQTKLWPSGCSHSSGERVRKPTSAEAETKTKDEMAAAEEKVGKNEQGEP 10 20 30 40 50 340 350 360 370 380 390 pF1KE3 EDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPD 60 70 80 90 100 110 400 410 420 430 440 450 pF1KE3 LHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYN 120 130 140 150 160 170 460 470 480 490 500 510 pF1KE3 GESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITD 180 190 200 210 220 230 520 530 540 550 560 570 pF1KE3 GPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLW 240 250 260 270 280 290 580 590 600 610 620 630 pF1KE3 TDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELL 300 310 320 330 340 350 640 650 660 670 680 690 pF1KE3 LEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALP 360 370 380 390 400 410 700 710 720 730 740 750 pF1KE3 VLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEP 420 430 440 450 460 470 760 770 780 790 800 810 pF1KE3 LFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQN 480 490 500 510 520 530 820 830 840 850 860 870 pF1KE3 VQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVC 540 550 560 570 580 590 880 890 900 910 920 930 pF1KE3 RMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEI 600 610 620 630 640 650 940 950 960 970 980 990 pF1KE3 EVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFE 660 670 680 690 700 710 1000 1010 1020 1030 1040 1050 pF1KE3 KCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSAVITKSWPRTADNFDDILKHLLTLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSAVITKSWPRTADNFDDILKHLLTLAD 720 730 740 750 760 770 1060 1070 1080 1090 1100 1110 pF1KE3 VKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTKVVGDLLSGTILVGQLELIIKHKNQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTKVVGDLLSGTILVGQLELIIKHKNQF 780 790 800 810 820 830 1120 1130 1140 1150 1160 1170 pF1KE3 LDIWQLREKSLSPQDEKCAVEEALDWRREELLLLKKEKRCVDSLLKMCGNVKHLIQVDFG ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: XP_016 LDIWQLREKSLSPQDEQCAVEEALDWRREELLLLKKEKRCVDSLLKMCGNVKHLIQVDFG 840 850 860 870 880 890 1180 1190 1200 1210 1220 1230 pF1KE3 VLAVRHSQDLSSKRLNDTMTVRLSTSSNSQRATHYHLSSQVQEMAGKIDLLRDSHIFQLF ::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::: XP_016 VLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHYHLSSQVQEMAGKIDLLRDSHIFQLF 900 910 920 930 940 950 1240 1250 1260 1270 1280 1290 pF1KE3 WREAAEPLSEPKEDQEAAELLSEPEEESERHILELQEVYDYLYQPSYRKFIKLHQDLKSG :::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::: XP_016 WREAAEPLSEPKEDQEAAELLSEPEEESERHILELEEVYDYLYQPSYRKFIKLHQDLKSG 960 970 980 990 1000 1010 1300 1310 1320 1330 1340 1350 pF1KE3 EVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQGQRDWIKDRVEQIKEYHHLHQAVHAA :::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::: XP_016 EVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQDQRDWIKDRVEQIKEYHHLHQAVHAA 1020 1030 1040 1050 1060 1070 1360 1370 1380 1390 1400 1410 pF1KE3 KVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRETLDQINQELIQAKKLLQDISEARCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRETLDQINQELIQAKKLLQDISEARCK 1080 1090 1100 1110 1120 1130 1420 1430 1440 1450 1460 1470 pF1KE3 GLQALSLRKEFICWVREALGGINELKVFVDLASISAGENDIDVDRVACFHDAVQGYASLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLQALSLRKEFICWVREALGGINELKVFVDLASISAGENDIDVDRVACFHDAVQGYASLL 1140 1150 1160 1170 1180 1190 1480 1490 1500 1510 1520 1530 pF1KE3 FKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCDSARNLEWLKTVNESHGSVERSSLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCDSARNLEWLKTVNESHGSVERSSLTL 1200 1210 1220 1230 1240 1250 1540 1550 1560 1570 1580 1590 pF1KE3 ATAINQRGIYVIQAPKGGQKISPDTVLHLILPESPGSHEESREYSLEEVKELLNKLMLMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATAINQRGIYVIQAPKGGQKISPDTVLHLILPESPGSHEESREYSLEEVKELLNKLMLMS 1260 1270 1280 1290 1300 1310 1600 1610 1620 1630 1640 1650 pF1KE3 GKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGNMLFRTWIAMAYCSPKQGVSLQMDFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGNMLFRTWIAMAYCSPKQGVSLQMDFG 1320 1330 1340 1350 1360 1370 1660 1670 1680 1690 1700 1710 pF1KE3 LDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFVTQKRMEHFYLNFYTAEQLVYLSTEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFVTQKRMEHFYLNFYTAEQLVYLSTEL 1380 1390 1400 1410 1420 1430 1720 1730 1740 1750 1760 1770 pF1KE3 RKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSEAARYRMRRVMEELPLMLLSEFSLVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSEAARYRMRRVMEELPLMLLSEFSLVD 1440 1450 1460 1470 1480 1490 1780 1790 1800 1810 1820 1830 pF1KE3 KLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAGMGGSPVERCLPRGLQVGQPNLVVCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAGMGGSPVERCLPRGLQVGQPNLVVCG 1500 1510 1520 1530 1540 1550 1840 1850 1860 1870 1880 1890 pF1KE3 HSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTFEEVALLLRRCLTLGSLGHKVYSLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTFEEVALLLRRCLTLGSLGHKVYSLLF 1560 1570 1580 1590 1600 1610 1900 1910 1920 1930 1940 1950 pF1KE3 ADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCDGDWEHCYLPSAFSQHKVFVTPQAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCDGDWEHCYLPSAFSQHKVFVTPQAPL 1620 1630 1640 1650 1660 1670 1960 1970 1980 1990 2000 2010 pF1KE3 EAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVK 1680 1690 1700 1710 1720 1730 2020 2030 2040 2050 2060 2070 pF1KE3 NVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVPVLFHLDVTSSVQTGIWVFLFKLLIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVPVLFHLDVTSSVQTGIWVFLFKLLIL 1740 1750 1760 1770 1780 1790 2080 2090 2100 2110 2120 2130 pF1KE3 QYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSSSALRTRVPQFSFLDIFPKVTCRPPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSSSALRTRVPQFSFLDIFPKVTCRPPK 1800 1810 1820 1830 1840 1850 2140 2150 2160 2170 2180 2190 pF1KE3 EVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYLRRFNQNQDLDTFQYQEGSVEGTPEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYLRRFNQNQDLDTFQYQEGSVEGTPEE 1860 1870 1880 1890 1900 1910 2200 2210 2220 2230 2240 2250 pF1KE3 CLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEASLFCNPSFIGDTLRGFKKFVVTFMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEASLFCNPSFIGDTLRGFKKFVVTFMI 1920 1930 1940 1950 1960 1970 2260 2270 2280 2290 2300 2310 pF1KE3 FMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAPFSLRKRWESEPHPYVFFNDDHTTMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAPFSLRKRWESEPHPYVFFNDDHTTMT 1980 1990 2000 2010 2020 2030 2320 2330 2340 2350 2360 2370 pF1KE3 FIGFHLQPNINGSVDAINHLTGKVIKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLER :::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::: XP_016 FIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLER 2040 2050 2060 2070 2080 2090 2380 2390 2400 2410 2420 2430 pF1KE3 LCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDL 2100 2110 2120 2130 2140 2150 2440 2450 2460 2470 2480 2490 pF1KE3 RRGGTNADTIKLVKVHGGTTADMIYSRVREAENVAFANKDQHQLDTILFFDEANTTEAIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRGGTNADTIKLVKVHGGTTADMIYSRVREAENVAFANKDQHQLDTILFFDEANTTEAIS 2160 2170 2180 2190 2200 2210 2500 2510 2520 2530 2540 2550 pF1KE3 CIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHSEEMICRLESAGLGYRVSMEETADRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHSEEMICRLESAGLGYRVSMEETADRL 2220 2230 2240 2250 2260 2270 2560 2570 2580 2590 2600 2610 pF1KE3 GSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEKLYIQQIVQRLVESISLDENGTRVIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEKLYIQQIVQRLVESISLDENGTRVIT 2280 2290 2300 2310 2320 2330 2620 2630 2640 2650 2660 2670 pF1KE3 EVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWFHEHSAMLLAQLNAFLSKSSVSKNHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWFHEHSAMLLAQLNAFLSKSSVSKNHT 2340 2350 2360 2370 2380 2390 2680 2690 2700 2710 2720 2730 pF1KE3 ERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFFPKPYDDSRLLLDEITRAQDLFLDGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFFPKPYDDSRLLLDEITRAQDLFLDGV 2400 2410 2420 2430 2440 2450 2740 2750 2760 2770 2780 2790 pF1KE3 PLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKPGSSKSLAKTIVADAMQGPAAYSDLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKPGSSKSLAKTIVADAMQGPAAYSDLF 2460 2470 2480 2490 2500 2510 2800 2810 2820 2830 2840 2850 pF1KE3 RSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQGKDLQQYVSVVVLDEVGLAEDSPKMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQGKDLQQYVSVVVLDEVGLAEDSPKMP 2520 2530 2540 2550 2560 2570 2860 2870 2880 2890 2900 2910 pF1KE3 LKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDPAKMNRGIFVSRGSPNETELIESAKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDPAKMNRGIFVSRGSPNETELIESAKG 2580 2590 2600 2610 2620 2630 2920 2930 2940 2950 2960 2970 pF1KE3 ICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFFGLRDYYSLIKMVFAAAKASNRKPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFFGLRDYYSLIKMVFAAAKASNRKPSP 2640 2650 2660 2670 2680 2690 2980 2990 3000 3010 3020 3030 pF1KE3 QDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEEVSPMQLIKQNIFGPSQKVPGGEQED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEEVSPMQLIKQNIFGPSQKVPGGEQED 2700 2710 2720 2730 2740 2750 3040 3050 3060 3070 3080 3090 pF1KE3 AESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMET 2760 2770 2780 2790 2800 2810 3100 3110 3120 3130 3140 3150 pF1KE3 GKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDLGLGTHRVKCRVHPNFRLIVIEEKDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDLGLGTHRVKCRVHPNFRLIVIEEKDV 2820 2830 2840 2850 2860 2870 3160 3170 3180 3190 3200 3210 pF1KE3 VYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEELCAWVEKFINVKAHHFQKRHKYSPSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEELCAWVEKFINVKAHHFQKRHKYSPSD 2880 2890 2900 2910 2920 2930 3220 3230 3240 3250 3260 3270 pF1KE3 VFIGYHSDACASVVLQVIERQGPRALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VFIGYHSDACASVVLQVIERQGPRALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLG 2940 2950 2960 2970 2980 2990 3280 3290 3300 3310 3320 3330 pF1KE3 GFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLERHAIFTEITTFSRLLTSHDCEILESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLERHAIFTEITTFSRLLTSHDCEILESE 3000 3010 3020 3030 3040 3050 3340 3350 3360 3370 3380 3390 pF1KE3 VTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAKCKILIFQTDFEDGIRSAQLIASAKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAKCKILIFQTDFEDGIRSAQLIASAKY 3060 3070 3080 3090 3100 3110 3400 3410 3420 3430 3440 3450 pF1KE3 SVINEINKIRENEDRIFVYFITKLSRVGRGTAYVGFHGGLWQSVHIDDLRRSTLMVSDVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVINEINKIRENEDRIFVYFITKLSRVGRGTAYVGFHGGLWQSVHIDDLRRSTLMVSDVT 3120 3130 3140 3150 3160 3170 3460 3470 3480 3490 3500 3510 pF1KE3 RLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMETEASTSGEVAEVAEEAMETESSEKVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMETEASTSGEVAEVAEEAMETESSEKVG 3180 3190 3200 3210 3220 3230 3520 3530 3540 3550 3560 3570 pF1KE3 KETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQNESCTRNMRRVVLLLGLLNEDDACHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQNESCTRNMRRVVLLLGLLNEDDACHA 3240 3250 3260 3270 3280 3290 3580 3590 3600 3610 3620 3630 pF1KE3 SFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLL 3300 3310 3320 3330 3340 3350 3640 3650 3660 3670 3680 3690 pF1KE3 ASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSDTMLLNIPLVMNNERHKGEMAYIVVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSDTMLLNIPLVMNNERHKGEMAYIVVQ 3360 3370 3380 3390 3400 3410 3700 3710 3720 3730 3740 3750 pF1KE3 NHMNLSENASNNVPFSWKIKDYLEELWVQAQYITDAEGLPKKFVDIFQQTPLGRFLAQLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NHMNLSENASNNVPFSWKIKDYLEELWVQAQYITDAEGLPKKFVDIFQQTPLGRFLAQLH 3420 3430 3440 3450 3460 3470 3760 3770 3780 3790 3800 3810 pF1KE3 GEPQQELLQCYLKDFILLTMRVSTEEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GEPQQELLQCYLKDFILLTMRVSTEEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHL 3480 3490 3500 3510 3520 3530 3820 3830 3840 3850 3860 3870 pF1KE3 AYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHELAGCEMTLDAFAAMACTEMLTRNTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHELAGCEMTLDAFAAMACTEMLTRNTLK 3540 3550 3560 3570 3580 3590 3880 3890 3900 3910 3920 3930 pF1KE3 PSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQAVIREVRAQWSRIFSTALFVEHVLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQAVIREVRAQWSRIFSTALFVEHVLLG 3600 3610 3620 3630 3640 3650 3940 3950 3960 3970 3980 3990 pF1KE3 TESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPFEAVMRTLCECKETASKTLSRFGIQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPFEAVMRTLCECKETASKTLSRFGIQP 3660 3670 3680 3690 3700 3710 4000 4010 4020 4030 4040 4050 pF1KE3 CSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMICPYCLTALPDEFSPAVSQAHREAIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMICPYCLTALPDEFSPAVSQAHREAIE 3720 3730 3740 3750 3760 3770 4060 4070 4080 4090 4100 4110 pF1KE3 KHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIESLLSLLFVQKGRLRDAAQRHCEHTKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIESLLSLLFVQKGRLRDAAQRHCEHTKS 3780 3790 3800 3810 3820 3830 4120 4130 4140 4150 4160 4170 pF1KE3 LSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQEYLTLLKKKAFITEDKTELYMLFIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQEYLTLLKKKAFITEDKTELYMLFIN 3840 3850 3860 3870 3880 3890 4180 4190 4200 4210 4220 4230 pF1KE3 CLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPASRGREPANEASVEYLQEVARIRLCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPASRGREPANEASVEYLQEVARIRLCL 3900 3910 3920 3930 3940 3950 4240 4250 4260 4270 4280 4290 pF1KE3 DRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVENDWHRVYLVRKLSSQRGMEFVQGLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVENDWHRVYLVRKLSSQRGMEFVQGLS 3960 3970 3980 3990 4000 4010 4300 4310 4320 4330 4340 4350 pF1KE3 KPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYGDEYKALRDAVAKAVLECKPLGIKTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYGDEYKALRDAVAKAVLECKPLGIKTA 4020 4030 4040 4050 4060 4070 4360 4370 4380 4390 4400 4410 pF1KE3 LKACKTPQSQQSAYFLLTLFREVAILYRSHNASLHPTPEQCEAVSKFIGECKILSPPDIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKACKTPQSQQSAYFLLTLFREVAILYRSHNASLHPTPEQCEAVSKFIGECKILSPPDIS 4080 4090 4100 4110 4120 4130 4420 4430 4440 4450 4460 4470 pF1KE3 RFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAAAVLLCGQNELLEPLKNLAFSPATMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAAAVLLCGQNELLEPLKNLAFSPATMA 4140 4150 4160 4170 4180 4190 4480 4490 4500 4510 4520 4530 pF1KE3 HAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPCSVGECGRPMEQSICIDCHAPIGGID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPCSVGECGRPMEQSICIDCHAPIGGID 4200 4210 4220 4230 4240 4250 4540 4550 4560 4570 4580 4590 pF1KE3 HKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCDRGLPPVVFLLIRLLTHLALLLGASQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCDRGLPPVVFLLIRLLTHLALLLGASQ 4260 4270 4280 4290 4300 4310 4600 4610 4620 4630 4640 4650 pF1KE3 SSQALINIIKPPVRDPKGFLQQHILKDLEQLAKMLGHSADETIGVVHLVLRRLLQEQHQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSQALINIIKPPVRDPKGFLQQHILKDLEQLAKMLGHSADETIGVVHLVLRRLLQEQHQL 4320 4330 4340 4350 4360 4370 4660 4670 4680 4690 4700 4710 pF1KE3 SSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEHLDKTLPTMNNLISQDKRISSNPVAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEHLDKTLPTMNNLISQDKRISSNPVAK 4380 4390 4400 4410 4420 4430 4720 4730 4740 4750 4760 4770 pF1KE3 IIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEYLQHIVEQKNGKERVPILWHFLQKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEYLQHIVEQKNGKERVPILWHFLQKEA 4440 4450 4460 4470 4480 4490 4780 4790 4800 4810 4820 4830 pF1KE3 ELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRGFLSKHSSDGLRQLLHNRITVFLSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRGFLSKHSSDGLRQLLHNRITVFLSTW 4500 4510 4520 4530 4540 4550 4840 4850 4860 4870 4880 4890 pF1KE3 NKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLPRRRGLGLCATALVSYLIRLHNEIVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLPRRRGLGLCATALVSYLIRLHNEIVY 4560 4570 4580 4590 4600 4610 4900 4910 4920 4930 4940 4950 pF1KE3 AVEKLSKENNSYSVDAAEVTELHVISYEVERDLTPLILSNCQYQVEEGRETVQEFDLEKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVEKLSKENNSYSVDAAEVTELHVISYEVERDLTPLILSNCQYQVEEGRETVQEFDLEKI 4620 4630 4640 4650 4660 4670 4960 4970 4980 4990 5000 5010 pF1KE3 QRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLFMDIKNKMAQDSLPSSVISAISGQLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLFMDIKNKMAQDSLPSSVISAISGQLQ 4680 4690 4700 4710 4720 4730 5020 5030 5040 5050 5060 5070 pF1KE3 SYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQDILQMGDQTIHVLKALNRCQLKHTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQDILQMGDQTIHVLKALNRCQLKHTI 4740 4750 4760 4770 4780 4790 5080 5090 5100 5110 5120 5130 pF1KE3 ALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSPENAKLLSTFLNQTGLDAFLLELHEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSPENAKLLSTFLNQTGLDAFLLELHEM 4800 4810 4820 4830 4840 4850 5140 5150 5160 5170 5180 5190 pF1KE3 IILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKESEILPEMASQFPEEILLASCVSVWKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKESEILPEMASQFPEEILLASCVSVWKT 4860 4870 4880 4890 4900 4910 5200 pF1KE3 AAVLKWNREMR ::::::::::: XP_016 AAVLKWNREMR 4920 >>XP_011523386 (OMIM: 607151,613768) PREDICTED: E3 ubiqu (4825 aa) initn: 31328 init1: 31328 opt: 31340 Z-score: 20860.6 bits: 3876.1 E(85289): 0 Smith-Waterman score: 31724; 98.8% identity (98.9% similar) in 4806 aa overlap (18-4774:18-4823) 10 20 30 40 50 60 pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG ::::::::::::::::::::::::::::::::::::::::::: XP_011 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG 10 20 30 40 50 60 70 80 pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQE--------------------------------- ::::::::::::::::::::::::::: XP_011 PCLFPGSDSWQENPEEPCSKASWTVQEGATSEVLVDAAVDLISDEWEAANAIPSKRRKQD 70 80 90 100 110 120 90 100 110 120 130 pF1KE3 ----------------SKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT :::::::::::::::::::::::::::::::::::::::::::: XP_011 AAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE3 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE3 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE3 EPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_011 EPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE3 EAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE3 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV 430 440 450 460 470 480 440 450 460 470 480 490 pF1KE3 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE3 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS 550 560 570 580 590 600 560 570 580 590 600 610 pF1KE3 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP 610 620 630 640 650 660 620 630 640 650 660 670 pF1KE3 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS 670 680 690 700 710 720 680 690 700 710 720 730 pF1KE3 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR 730 740 750 760 770 780 740 750 760 770 780 790 pF1KE3 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC 790 800 810 820 830 840 800 810 820 830 840 850 pF1KE3 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL 850 860 870 880 890 900 860 870 880 890 900 910 pF1KE3 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK 910 920 930 940 950 960 920 930 940 950 960 970 pF1KE3 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL 970 980 990 1000 1010 1020 980 990 1000 1010 1020 1030 pF1KE3 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA 1030 1040 1050 1060 1070 1080 1040 1050 1060 1070 1080 1090 pF1KE3 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK 1090 1100 1110 1120 1130 1140 1100 1110 1120 1130 1140 1150 pF1KE3 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEKCAVEEALDWRREELLLLK :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: XP_011 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEALDWRREELLLLK 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 1210 pF1KE3 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTMTVRLSTSSNSQRATHY :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: XP_011 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHY 1210 1220 1230 1240 1250 1260 1220 1230 1240 1250 1260 1270 pF1KE3 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KE3 QEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQG .:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQD 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 1380 1390 pF1KE3 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE 1390 1400 1410 1420 1430 1440 1400 1410 1420 1430 1440 1450 pF1KE3 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS 1450 1460 1470 1480 1490 1500 1460 1470 1480 1490 1500 1510 pF1KE3 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD 1510 1520 1530 1540 1550 1560 1520 1530 1540 1550 1560 1570 pF1KE3 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP 1570 1580 1590 1600 1610 1620 1580 1590 1600 1610 1620 1630 pF1KE3 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN 1630 1640 1650 1660 1670 1680 1640 1650 1660 1670 1680 1690 pF1KE3 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV 1690 1700 1710 1720 1730 1740 1700 1710 1720 1730 1740 1750 pF1KE3 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE 1750 1760 1770 1780 1790 1800 1760 1770 1780 1790 1800 1810 pF1KE3 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG 1810 1820 1830 1840 1850 1860 1820 1830 1840 1850 1860 1870 pF1KE3 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF 1870 1880 1890 1900 1910 1920 1880 1890 1900 1910 1920 1930 pF1KE3 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD 1930 1940 1950 1960 1970 1980 1940 1950 1960 1970 1980 1990 pF1KE3 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS 1990 2000 2010 2020 2030 2040 2000 2010 2020 2030 2040 2050 pF1KE3 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP 2050 2060 2070 2080 2090 2100 2060 2070 2080 2090 2100 2110 pF1KE3 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS 2110 2120 2130 2140 2150 2160 2120 2130 2140 2150 2160 2170 pF1KE3 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL 2170 2180 2190 2200 2210 2220 2180 2190 2200 2210 2220 2230 pF1KE3 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA 2230 2240 2250 2260 2270 2280 2240 2250 2260 2270 2280 2290 pF1KE3 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP 2290 2300 2310 2320 2330 2340 2300 2310 2320 2330 2340 2350 pF1KE3 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAINHLTGKVIKRDVMTRDLY ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: XP_011 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLY 2350 2360 2370 2380 2390 2400 2360 2370 2380 2390 2400 2410 pF1KE3 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR 2410 2420 2430 2440 2450 2460 2420 2430 2440 2450 2460 2470 pF1KE3 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA 2470 2480 2490 2500 2510 2520 2480 2490 2500 2510 2520 2530 pF1KE3 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS 2530 2540 2550 2560 2570 2580 2540 2550 2560 2570 2580 2590 pF1KE3 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK 2590 2600 2610 2620 2630 2640 2600 2610 2620 2630 2640 2650 pF1KE3 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF 2650 2660 2670 2680 2690 2700 2660 2670 2680 2690 2700 2710 pF1KE3 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF 2710 2720 2730 2740 2750 2760 2720 2730 2740 2750 2760 2770 pF1KE3 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP 2770 2780 2790 2800 2810 2820 2780 2790 2800 2810 2820 2830 pF1KE3 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG 2830 2840 2850 2860 2870 2880 2840 2850 2860 2870 2880 2890 pF1KE3 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP 2890 2900 2910 2920 2930 2940 2900 2910 2920 2930 2940 2950 pF1KE3 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF 2950 2960 2970 2980 2990 3000 2960 2970 2980 2990 3000 3010 pF1KE3 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE 3010 3020 3030 3040 3050 3060 3020 3030 3040 3050 3060 3070 pF1KE3 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG 3070 3080 3090 3100 3110 3120 3080 3090 3100 3110 3120 3130 pF1KE3 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL 3130 3140 3150 3160 3170 3180 3140 3150 3160 3170 3180 3190 pF1KE3 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL 3190 3200 3210 3220 3230 3240 3200 3210 3220 3230 3240 3250 pF1KE3 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS 3250 3260 3270 3280 3290 3300 3260 3270 3280 3290 3300 3310 pF1KE3 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER 3310 3320 3330 3340 3350 3360 3320 3330 3340 3350 3360 3370 pF1KE3 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK 3370 3380 3390 3400 3410 3420 3380 3390 3400 3410 3420 3430 pF1KE3 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG 3430 3440 3450 3460 3470 3480 3440 3450 3460 3470 3480 3490 pF1KE3 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET 3490 3500 3510 3520 3530 3540 3500 3510 3520 3530 3540 3550 pF1KE3 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN 3550 3560 3570 3580 3590 3600 3560 3570 3580 3590 3600 3610 pF1KE3 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ 3610 3620 3630 3640 3650 3660 3620 3630 3640 3650 3660 3670 pF1KE3 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD 3670 3680 3690 3700 3710 3720 3680 3690 3700 3710 3720 3730 pF1KE3 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD 3730 3740 3750 3760 3770 3780 3740 3750 3760 3770 3780 3790 pF1KE3 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL 3790 3800 3810 3820 3830 3840 3800 3810 3820 3830 3840 3850 pF1KE3 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL 3850 3860 3870 3880 3890 3900 3860 3870 3880 3890 3900 3910 pF1KE3 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA 3910 3920 3930 3940 3950 3960 3920 3930 3940 3950 3960 3970 pF1KE3 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF 3970 3980 3990 4000 4010 4020 3980 3990 4000 4010 4020 4030 pF1KE3 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI 4030 4040 4050 4060 4070 4080 4040 4050 4060 4070 4080 4090 pF1KE3 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES 4090 4100 4110 4120 4130 4140 4100 4110 4120 4130 4140 4150 pF1KE3 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ 4150 4160 4170 4180 4190 4200 4160 4170 4180 4190 4200 4210 pF1KE3 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA 4210 4220 4230 4240 4250 4260 4220 4230 4240 4250 4260 4270 pF1KE3 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE 4270 4280 4290 4300 4310 4320 4280 4290 4300 4310 4320 4330 pF1KE3 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG 4330 4340 4350 4360 4370 4380 4340 4350 4360 4370 4380 4390 pF1KE3 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH 4390 4400 4410 4420 4430 4440 4400 4410 4420 4430 4440 4450 pF1KE3 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA 4450 4460 4470 4480 4490 4500 4460 4470 4480 4490 4500 4510 pF1KE3 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC 4510 4520 4530 4540 4550 4560 4520 4530 4540 4550 4560 4570 pF1KE3 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD 4570 4580 4590 4600 4610 4620 4580 4590 4600 4610 4620 4630 pF1KE3 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML 4630 4640 4650 4660 4670 4680 4640 4650 4660 4670 4680 4690 pF1KE3 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH 4690 4700 4710 4720 4730 4740 4700 4710 4720 4730 4740 4750 pF1KE3 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY 4750 4760 4770 4780 4790 4800 4760 4770 4780 4790 4800 4810 pF1KE3 LQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRG ::::::::::::::::::::::: XP_011 LQHIVEQKNGKERVPILWHFLQKMG 4810 4820 >>XP_011523388 (OMIM: 607151,613768) PREDICTED: E3 ubiqu (4192 aa) initn: 27049 init1: 27049 opt: 27061 Z-score: 18013.6 bits: 3349.1 E(85289): 0 Smith-Waterman score: 27445; 98.7% identity (98.8% similar) in 4173 aa overlap (18-4141:18-4190) 10 20 30 40 50 60 pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG ::::::::::::::::::::::::::::::::::::::::::: XP_011 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG 10 20 30 40 50 60 70 80 pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQE--------------------------------- ::::::::::::::::::::::::::: XP_011 PCLFPGSDSWQENPEEPCSKASWTVQEGATSEVLVDAAVDLISDEWEAANAIPSKRRKQD 70 80 90 100 110 120 90 100 110 120 130 pF1KE3 ----------------SKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT :::::::::::::::::::::::::::::::::::::::::::: XP_011 AAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE3 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE3 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE3 EPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_011 EPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE3 EAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE3 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV 430 440 450 460 470 480 440 450 460 470 480 490 pF1KE3 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE3 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS 550 560 570 580 590 600 560 570 580 590 600 610 pF1KE3 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP 610 620 630 640 650 660 620 630 640 650 660 670 pF1KE3 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS 670 680 690 700 710 720 680 690 700 710 720 730 pF1KE3 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR 730 740 750 760 770 780 740 750 760 770 780 790 pF1KE3 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC 790 800 810 820 830 840 800 810 820 830 840 850 pF1KE3 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL 850 860 870 880 890 900 860 870 880 890 900 910 pF1KE3 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK 910 920 930 940 950 960 920 930 940 950 960 970 pF1KE3 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL 970 980 990 1000 1010 1020 980 990 1000 1010 1020 1030 pF1KE3 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA 1030 1040 1050 1060 1070 1080 1040 1050 1060 1070 1080 1090 pF1KE3 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK 1090 1100 1110 1120 1130 1140 1100 1110 1120 1130 1140 1150 pF1KE3 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEKCAVEEALDWRREELLLLK :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: XP_011 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEALDWRREELLLLK 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 1210 pF1KE3 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTMTVRLSTSSNSQRATHY :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: XP_011 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHY 1210 1220 1230 1240 1250 1260 1220 1230 1240 1250 1260 1270 pF1KE3 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KE3 QEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQG .:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQD 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 1380 1390 pF1KE3 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE 1390 1400 1410 1420 1430 1440 1400 1410 1420 1430 1440 1450 pF1KE3 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS 1450 1460 1470 1480 1490 1500 1460 1470 1480 1490 1500 1510 pF1KE3 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD 1510 1520 1530 1540 1550 1560 1520 1530 1540 1550 1560 1570 pF1KE3 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP 1570 1580 1590 1600 1610 1620 1580 1590 1600 1610 1620 1630 pF1KE3 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN 1630 1640 1650 1660 1670 1680 1640 1650 1660 1670 1680 1690 pF1KE3 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV 1690 1700 1710 1720 1730 1740 1700 1710 1720 1730 1740 1750 pF1KE3 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE 1750 1760 1770 1780 1790 1800 1760 1770 1780 1790 1800 1810 pF1KE3 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG 1810 1820 1830 1840 1850 1860 1820 1830 1840 1850 1860 1870 pF1KE3 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF 1870 1880 1890 1900 1910 1920 1880 1890 1900 1910 1920 1930 pF1KE3 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD 1930 1940 1950 1960 1970 1980 1940 1950 1960 1970 1980 1990 pF1KE3 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS 1990 2000 2010 2020 2030 2040 2000 2010 2020 2030 2040 2050 pF1KE3 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP 2050 2060 2070 2080 2090 2100 2060 2070 2080 2090 2100 2110 pF1KE3 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS 2110 2120 2130 2140 2150 2160 2120 2130 2140 2150 2160 2170 pF1KE3 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL 2170 2180 2190 2200 2210 2220 2180 2190 2200 2210 2220 2230 pF1KE3 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA 2230 2240 2250 2260 2270 2280 2240 2250 2260 2270 2280 2290 pF1KE3 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP 2290 2300 2310 2320 2330 2340 2300 2310 2320 2330 2340 2350 pF1KE3 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAINHLTGKVIKRDVMTRDLY ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: XP_011 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLY 2350 2360 2370 2380 2390 2400 2360 2370 2380 2390 2400 2410 pF1KE3 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR 2410 2420 2430 2440 2450 2460 2420 2430 2440 2450 2460 2470 pF1KE3 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA 2470 2480 2490 2500 2510 2520 2480 2490 2500 2510 2520 2530 pF1KE3 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS 2530 2540 2550 2560 2570 2580 2540 2550 2560 2570 2580 2590 pF1KE3 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK 2590 2600 2610 2620 2630 2640 2600 2610 2620 2630 2640 2650 pF1KE3 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF 2650 2660 2670 2680 2690 2700 2660 2670 2680 2690 2700 2710 pF1KE3 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF 2710 2720 2730 2740 2750 2760 2720 2730 2740 2750 2760 2770 pF1KE3 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP 2770 2780 2790 2800 2810 2820 2780 2790 2800 2810 2820 2830 pF1KE3 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG 2830 2840 2850 2860 2870 2880 2840 2850 2860 2870 2880 2890 pF1KE3 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP 2890 2900 2910 2920 2930 2940 2900 2910 2920 2930 2940 2950 pF1KE3 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF 2950 2960 2970 2980 2990 3000 2960 2970 2980 2990 3000 3010 pF1KE3 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE 3010 3020 3030 3040 3050 3060 3020 3030 3040 3050 3060 3070 pF1KE3 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG 3070 3080 3090 3100 3110 3120 3080 3090 3100 3110 3120 3130 pF1KE3 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL 3130 3140 3150 3160 3170 3180 3140 3150 3160 3170 3180 3190 pF1KE3 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL 3190 3200 3210 3220 3230 3240 3200 3210 3220 3230 3240 3250 pF1KE3 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS 3250 3260 3270 3280 3290 3300 3260 3270 3280 3290 3300 3310 pF1KE3 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER 3310 3320 3330 3340 3350 3360 3320 3330 3340 3350 3360 3370 pF1KE3 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK 3370 3380 3390 3400 3410 3420 3380 3390 3400 3410 3420 3430 pF1KE3 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG 3430 3440 3450 3460 3470 3480 3440 3450 3460 3470 3480 3490 pF1KE3 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET 3490 3500 3510 3520 3530 3540 3500 3510 3520 3530 3540 3550 pF1KE3 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN 3550 3560 3570 3580 3590 3600 3560 3570 3580 3590 3600 3610 pF1KE3 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ 3610 3620 3630 3640 3650 3660 3620 3630 3640 3650 3660 3670 pF1KE3 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD 3670 3680 3690 3700 3710 3720 3680 3690 3700 3710 3720 3730 pF1KE3 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD 3730 3740 3750 3760 3770 3780 3740 3750 3760 3770 3780 3790 pF1KE3 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL 3790 3800 3810 3820 3830 3840 3800 3810 3820 3830 3840 3850 pF1KE3 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL 3850 3860 3870 3880 3890 3900 3860 3870 3880 3890 3900 3910 pF1KE3 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA 3910 3920 3930 3940 3950 3960 3920 3930 3940 3950 3960 3970 pF1KE3 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF 3970 3980 3990 4000 4010 4020 3980 3990 4000 4010 4020 4030 pF1KE3 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI 4030 4040 4050 4060 4070 4080 4040 4050 4060 4070 4080 4090 pF1KE3 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES 4090 4100 4110 4120 4130 4140 4100 4110 4120 4130 4140 4150 pF1KE3 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYRW 4150 4160 4170 4180 4190 4160 4170 4180 4190 4200 4210 pF1KE3 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA >>XP_011523389 (OMIM: 607151,613768) PREDICTED: E3 ubiqu (3824 aa) initn: 24278 init1: 24278 opt: 24290 Z-score: 16170.0 bits: 3007.8 E(85289): 0 Smith-Waterman score: 24674; 98.5% identity (98.6% similar) in 3765 aa overlap (18-3733:18-3782) 10 20 30 40 50 60 pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG ::::::::::::::::::::::::::::::::::::::::::: XP_011 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG 10 20 30 40 50 60 70 80 pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQE--------------------------------- ::::::::::::::::::::::::::: XP_011 PCLFPGSDSWQENPEEPCSKASWTVQEGATSEVLVDAAVDLISDEWEAANAIPSKRRKQD 70 80 90 100 110 120 90 100 110 120 130 pF1KE3 ----------------SKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT :::::::::::::::::::::::::::::::::::::::::::: XP_011 AAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE3 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE3 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE3 EPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_011 EPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE3 EAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE3 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV 430 440 450 460 470 480 440 450 460 470 480 490 pF1KE3 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE3 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS 550 560 570 580 590 600 560 570 580 590 600 610 pF1KE3 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP 610 620 630 640 650 660 620 630 640 650 660 670 pF1KE3 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS 670 680 690 700 710 720 680 690 700 710 720 730 pF1KE3 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR 730 740 750 760 770 780 740 750 760 770 780 790 pF1KE3 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC 790 800 810 820 830 840 800 810 820 830 840 850 pF1KE3 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL 850 860 870 880 890 900 860 870 880 890 900 910 pF1KE3 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK 910 920 930 940 950 960 920 930 940 950 960 970 pF1KE3 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL 970 980 990 1000 1010 1020 980 990 1000 1010 1020 1030 pF1KE3 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA 1030 1040 1050 1060 1070 1080 1040 1050 1060 1070 1080 1090 pF1KE3 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK 1090 1100 1110 1120 1130 1140 1100 1110 1120 1130 1140 1150 pF1KE3 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEKCAVEEALDWRREELLLLK :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: XP_011 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEALDWRREELLLLK 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 1210 pF1KE3 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTMTVRLSTSSNSQRATHY :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: XP_011 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHY 1210 1220 1230 1240 1250 1260 1220 1230 1240 1250 1260 1270 pF1KE3 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KE3 QEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQG .:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQD 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 1380 1390 pF1KE3 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE 1390 1400 1410 1420 1430 1440 1400 1410 1420 1430 1440 1450 pF1KE3 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS 1450 1460 1470 1480 1490 1500 1460 1470 1480 1490 1500 1510 pF1KE3 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD 1510 1520 1530 1540 1550 1560 1520 1530 1540 1550 1560 1570 pF1KE3 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP 1570 1580 1590 1600 1610 1620 1580 1590 1600 1610 1620 1630 pF1KE3 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN 1630 1640 1650 1660 1670 1680 1640 1650 1660 1670 1680 1690 pF1KE3 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV 1690 1700 1710 1720 1730 1740 1700 1710 1720 1730 1740 1750 pF1KE3 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE 1750 1760 1770 1780 1790 1800 1760 1770 1780 1790 1800 1810 pF1KE3 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG 1810 1820 1830 1840 1850 1860 1820 1830 1840 1850 1860 1870 pF1KE3 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF 1870 1880 1890 1900 1910 1920 1880 1890 1900 1910 1920 1930 pF1KE3 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD 1930 1940 1950 1960 1970 1980 1940 1950 1960 1970 1980 1990 pF1KE3 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS 1990 2000 2010 2020 2030 2040 2000 2010 2020 2030 2040 2050 pF1KE3 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP 2050 2060 2070 2080 2090 2100 2060 2070 2080 2090 2100 2110 pF1KE3 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS 2110 2120 2130 2140 2150 2160 2120 2130 2140 2150 2160 2170 pF1KE3 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL 2170 2180 2190 2200 2210 2220 2180 2190 2200 2210 2220 2230 pF1KE3 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA 2230 2240 2250 2260 2270 2280 2240 2250 2260 2270 2280 2290 pF1KE3 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP 2290 2300 2310 2320 2330 2340 2300 2310 2320 2330 2340 2350 pF1KE3 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAINHLTGKVIKRDVMTRDLY ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: XP_011 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLY 2350 2360 2370 2380 2390 2400 2360 2370 2380 2390 2400 2410 pF1KE3 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR 2410 2420 2430 2440 2450 2460 2420 2430 2440 2450 2460 2470 pF1KE3 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA 2470 2480 2490 2500 2510 2520 2480 2490 2500 2510 2520 2530 pF1KE3 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS 2530 2540 2550 2560 2570 2580 2540 2550 2560 2570 2580 2590 pF1KE3 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK 2590 2600 2610 2620 2630 2640 2600 2610 2620 2630 2640 2650 pF1KE3 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF 2650 2660 2670 2680 2690 2700 2660 2670 2680 2690 2700 2710 pF1KE3 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF 2710 2720 2730 2740 2750 2760 2720 2730 2740 2750 2760 2770 pF1KE3 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP 2770 2780 2790 2800 2810 2820 2780 2790 2800 2810 2820 2830 pF1KE3 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG 2830 2840 2850 2860 2870 2880 2840 2850 2860 2870 2880 2890 pF1KE3 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP 2890 2900 2910 2920 2930 2940 2900 2910 2920 2930 2940 2950 pF1KE3 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF 2950 2960 2970 2980 2990 3000 2960 2970 2980 2990 3000 3010 pF1KE3 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE 3010 3020 3030 3040 3050 3060 3020 3030 3040 3050 3060 3070 pF1KE3 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG 3070 3080 3090 3100 3110 3120 3080 3090 3100 3110 3120 3130 pF1KE3 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL 3130 3140 3150 3160 3170 3180 3140 3150 3160 3170 3180 3190 pF1KE3 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL 3190 3200 3210 3220 3230 3240 3200 3210 3220 3230 3240 3250 pF1KE3 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS 3250 3260 3270 3280 3290 3300 3260 3270 3280 3290 3300 3310 pF1KE3 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER 3310 3320 3330 3340 3350 3360 3320 3330 3340 3350 3360 3370 pF1KE3 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK 3370 3380 3390 3400 3410 3420 3380 3390 3400 3410 3420 3430 pF1KE3 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG 3430 3440 3450 3460 3470 3480 3440 3450 3460 3470 3480 3490 pF1KE3 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET 3490 3500 3510 3520 3530 3540 3500 3510 3520 3530 3540 3550 pF1KE3 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN 3550 3560 3570 3580 3590 3600 3560 3570 3580 3590 3600 3610 pF1KE3 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ 3610 3620 3630 3640 3650 3660 3620 3630 3640 3650 3660 3670 pF1KE3 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD 3670 3680 3690 3700 3710 3720 3680 3690 3700 3710 3720 3730 pF1KE3 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD 3730 3740 3750 3760 3770 3780 3740 3750 3760 3770 3780 3790 pF1KE3 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL :: XP_011 AEVSVQFTSPRHFKVSAEGVRGPGGTRNLSILWQQEPVRWFLVP 3790 3800 3810 3820 >>NP_066005 (OMIM: 607151,613768) E3 ubiquitin-protein l (1063 aa) initn: 6841 init1: 6841 opt: 6841 Z-score: 4565.1 bits: 858.7 E(85289): 0 Smith-Waterman score: 6841; 99.8% identity (99.8% similar) in 1008 aa overlap (1-1008:1-1008) 10 20 30 40 50 60 pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 TLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LLLPESKGGSSEPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPP ::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::: NP_066 LLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 ATTPPFKTHCQEAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_066 ATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICEL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 HYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 HYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 FIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 FIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 LPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 LPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 DLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 DLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEH 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 LGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 LGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEAL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 SPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 SPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGD 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 MEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYS :::::::::::::::::::::::::::::::::::::::::::::::: NP_066 MEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQVNNLSSWETDSG 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 DLRKFGIVLSAVITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKR NP_066 SQLCSAMTQLRAMKHPLGLSSSANSEIGKWAPSSLAKGNGAEI 1030 1040 1050 1060 5207 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 20:24:02 2016 done: Mon Nov 7 20:24:08 2016 Total Scan time: 34.070 Total Display time: 7.500 Function used was FASTA [36.3.4 Apr, 2011]