FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2378, 488 aa 1>>>pF1KE2378 488 - 488 aa - 488 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8850+/-0.00104; mu= 10.6266+/- 0.063 mean_var=116.1702+/-23.088, 0's: 0 Z-trim(107.1): 45 B-trim: 448 in 1/48 Lambda= 0.118994 statistics sampled from 9346 (9381) to 9346 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.288), width: 16 Scan time: 2.920 The best scores are: opt bits E(32554) CCDS43493.2 HDAC2 gene_id:3066|Hs108|chr6 ( 488) 3343 585.3 5.1e-167 CCDS360.1 HDAC1 gene_id:3065|Hs108|chr1 ( 482) 2880 505.8 4.3e-143 CCDS4264.1 HDAC3 gene_id:8841|Hs108|chr5 ( 428) 1833 326.0 5e-89 CCDS14420.1 HDAC8 gene_id:55869|Hs108|chrX ( 377) 1089 198.2 1.3e-50 CCDS55449.1 HDAC8 gene_id:55869|Hs108|chrX ( 286) 821 152.2 7.2e-37 CCDS55451.1 HDAC8 gene_id:55869|Hs108|chrX ( 256) 721 135.0 9.6e-32 CCDS14306.1 HDAC6 gene_id:10013|Hs108|chrX (1215) 384 77.5 9e-14 CCDS83163.1 HDAC9 gene_id:9734|Hs108|chr7 (1025) 368 74.7 5.2e-13 CCDS47554.1 HDAC9 gene_id:9734|Hs108|chr7 (1066) 368 74.7 5.4e-13 CCDS47553.1 HDAC9 gene_id:9734|Hs108|chr7 (1069) 368 74.7 5.4e-13 CCDS47555.1 HDAC9 gene_id:9734|Hs108|chr7 (1011) 342 70.3 1.1e-11 CCDS14088.1 HDAC10 gene_id:83933|Hs108|chr22 ( 669) 332 68.4 2.7e-11 CCDS2529.1 HDAC4 gene_id:9759|Hs108|chr2 (1084) 333 68.7 3.5e-11 CCDS45696.1 HDAC5 gene_id:10014|Hs108|chr17 (1122) 333 68.7 3.6e-11 CCDS32663.1 HDAC5 gene_id:10014|Hs108|chr17 (1123) 333 68.7 3.6e-11 CCDS41776.1 HDAC7 gene_id:51564|Hs108|chr12 ( 954) 329 68.0 5.1e-11 CCDS81685.1 HDAC7 gene_id:51564|Hs108|chr12 ( 974) 329 68.0 5.2e-11 CCDS8756.2 HDAC7 gene_id:51564|Hs108|chr12 ( 991) 329 68.0 5.3e-11 >>CCDS43493.2 HDAC2 gene_id:3066|Hs108|chr6 (488 aa) initn: 3343 init1: 3343 opt: 3343 Z-score: 3111.9 bits: 585.3 E(32554): 5.1e-167 Smith-Waterman score: 3343; 100.0% identity (100.0% similar) in 488 aa overlap (1-488:1-488) 10 20 30 40 50 60 pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT 430 440 450 460 470 480 pF1KE2 KSEQLSNP :::::::: CCDS43 KSEQLSNP >>CCDS360.1 HDAC1 gene_id:3065|Hs108|chr1 (482 aa) initn: 2951 init1: 2811 opt: 2880 Z-score: 2682.4 bits: 505.8 E(32554): 4.3e-143 Smith-Waterman score: 2880; 85.9% identity (95.0% similar) in 483 aa overlap (1-483:1-478) 10 20 30 40 50 60 pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA :: .:: ..:::::::::.:::::::::::::::::::::::::::::::::::::::: CCDS36 MAQTQGT-RRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA .::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 NAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH .:::::.::::.:::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 SAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ ::::::::::::::::::::::::::::::::::::::::::::::.:.::::::::: CCDS36 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG ::::..::::::.::::::::::.::::::::::::::.:::::::: ::.::::.:::: CCDS36 IFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLG 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE2 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM :::::::::::::::::::::: ::::::::::::::::::::::::::::::::: ::. CCDS36 GGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYL 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE :::::::::::::::::::::::::::::. :.::::: .:::::::: .:::::::.:: CCDS36 EKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEE 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE2 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT :::::.::::::.: .. :: ::... :..:.. ..: .: ::.:.:. :: ..::. CCDS36 FSDSEEEGEGGRKNSSNFKK-AKRVKTEDEKEKDPEEKKEVTEEEKTKE---EKPEAKGV 420 430 440 450 460 470 pF1KE2 KSEQLSNP : : CCDS36 KEEVKLA 480 >>CCDS4264.1 HDAC3 gene_id:8841|Hs108|chr5 (428 aa) initn: 1131 init1: 978 opt: 1833 Z-score: 1711.8 bits: 326.0 E(32554): 5e-89 Smith-Waterman score: 1833; 58.8% identity (84.4% similar) in 422 aa overlap (10-429:3-421) 10 20 30 40 50 60 pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA : : :.:: :.::..:: ::::::::. .::.:.:.::::.:: ...:..: CCDS42 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQA 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA . ..: ..::..:: ::. . : ::. ..:... ::::.::::: ::::::. ::.:. CCDS42 SQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQ 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH ::..:: . :.:.::::::::::: ::::::::::::..:::::::: ::::::::::: CCDS42 GATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHH 120 130 140 150 160 170 190 200 210 220 230 pF1KE2 GDGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYG ::::.:::: :::::::::::::.:: :::::. ..:: .:.:: .: :.::::::.:: CCDS42 GDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 QIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLML ..:.:.:..:...:::. .:::::::::. ::::::::...::..::: ::.::.:::.: CCDS42 HLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 GGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN-MTNQNTPE ::::::.:::::::::::.. .. : .::::..:::::.::: :: . :. . :::. . CCDS42 GGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQ 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 YMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACD :...:.: .::::.:: :::.::.. .: : . : :: : ..: . . . .: CCDS42 YLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDE--ADAEER-GPEENYSRPEAP 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 EEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTK .:: :.. ... CCDS42 NEFYDGDHDNDKESDVEI 420 >>CCDS14420.1 HDAC8 gene_id:55869|Hs108|chrX (377 aa) initn: 975 init1: 551 opt: 1089 Z-score: 1022.3 bits: 198.2 E(32554): 1.3e-50 Smith-Waterman score: 1089; 43.4% identity (77.1% similar) in 341 aa overlap (33-372:35-374) 10 20 30 40 50 60 pF1KE2 YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATA :.: :.:.:. :.:...:.: .:. :. CCDS14 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 EEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGA :::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....: CCDS14 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD : . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.:::: CCDS14 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI :::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: :: CCDS14 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG . ....:.. ..:.::::: :::...:: . ::.: : .::.. . ..: :.::: CCDS14 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYME :::.. :.:::::: :.: : . .:.: ...: .:::. :.:.:: ..: :. .. CCDS14 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEF .: . . ::. CCDS14 QILNYIKGNLKHVV 370 >>CCDS55449.1 HDAC8 gene_id:55869|Hs108|chrX (286 aa) initn: 842 init1: 551 opt: 821 Z-score: 775.4 bits: 152.2 E(32554): 7.2e-37 Smith-Waterman score: 821; 48.1% identity (78.9% similar) in 237 aa overlap (137-372:47-283) 110 120 130 140 150 160 pF1KE2 LFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLK : .::. ..:::::::.:: ::.::.: . CCDS55 VYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRDEASGFCYLNDAVLGILRLRR 20 30 40 50 60 70 170 180 190 200 210 220 pF1KE2 YHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAV .:.::.:.:.:::::::.:: :..:::::.::.. .::::::. :.: :::.::.: CCDS55 KFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSV 80 90 100 110 120 130 230 240 250 260 270 280 pF1KE2 NFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKC : :..:::.::.: :: . ....:.. ..:.::::: :::...:: . ::.: : .:: CCDS55 NVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKC 140 150 160 170 180 190 290 300 310 320 330 340 pF1KE2 VEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLH .. . ..: :.::::::.. :.:::::: :.: : . .:.: ...: .:::. :. CCDS55 LKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLE 200 210 220 230 240 250 350 360 370 380 390 400 pF1KE2 ISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKR :.:: ..: :. ...: . . ::. CCDS55 ITPSCRPDRNEPHRIQQILNYIKGNLKHVV 260 270 280 >>CCDS55451.1 HDAC8 gene_id:55869|Hs108|chrX (256 aa) initn: 578 init1: 405 opt: 721 Z-score: 683.4 bits: 135.0 E(32554): 9.6e-32 Smith-Waterman score: 721; 46.2% identity (79.5% similar) in 210 aa overlap (33-241:35-243) 10 20 30 40 50 60 pF1KE2 YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATA :.: :.:.:. :.:...:.: .:. :. CCDS55 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 EEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGA :::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....: CCDS55 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD : . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.:::: CCDS55 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI :::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: :: CCDS55 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG CCDS55 CERYEPPAPNPGL 250 >>CCDS14306.1 HDAC6 gene_id:10013|Hs108|chrX (1215 aa) initn: 242 init1: 111 opt: 384 Z-score: 360.7 bits: 77.5 E(32554): 9e-14 Smith-Waterman score: 384; 27.2% identity (55.3% similar) in 309 aa overlap (16-310:485-788) 10 20 30 40 pF1KE2 MAYSQGGGKKKVCYYYDGDIGNY--YYGQGHPMKPHRIRMTHNLL :: .. :. . . :: :.:: : CCDS14 VEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRL 460 470 480 490 500 510 50 60 70 80 90 100 pF1KE2 LNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPV . :: . :. :: :. :: ::. ::. . . : .. . :. :: CCDS14 EELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICP- 520 530 540 550 560 570 110 120 130 140 150 160 pF1KE2 FDGLFEFCQLSTGGS--VAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAI . : ::.::.. .. :: .. . :: : :::... : :::. :....: CCDS14 --STFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPG-HHAEQDAACGFCFFNSVAVAA 580 590 600 610 620 630 170 180 190 200 210 pF1KE2 --LELLKYHQ-RVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFP--GTGDLRD . .. : :.: .: :.:::.:... : :. ::.:.: : .:: : . CCDS14 RHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQ 640 650 660 670 680 690 220 230 240 250 260 270 pF1KE2 IGAGKGKYYAVNFPMRDG--IDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRL :: . : ..:: .: . : .: .. .. . ..: :... : :. :: : CCDS14 IGRAAGTGFTVNVAW-NGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPL 700 710 720 730 740 280 290 300 310 320 330 pF1KE2 GCFNLTVKGHAKCVEVVKTFNLP-LLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPY : ... .:.:. .... . .... :::.. ... CCDS14 GGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLP 750 760 770 780 790 800 340 350 360 370 380 390 pF1KE2 NDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVH CCDS14 RPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPRLAERMTT 810 820 830 840 850 860 >-- initn: 150 init1: 81 opt: 357 Z-score: 335.7 bits: 72.9 E(32554): 2.2e-12 Smith-Waterman score: 357; 27.7% identity (55.1% similar) in 292 aa overlap (30-310:106-392) 10 20 30 40 50 pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHK : :.:.. .. :.. :: . .. . CCDS14 LNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARF 80 90 100 110 120 130 60 70 80 90 100 110 pF1KE2 ATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSV : ::. :: ::: .... . : .: . . : . : ..::: CCDS14 AEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTY----DSVYLHPNSYSCACLASGSV 140 150 160 170 180 190 120 130 140 150 160 170 pF1KE2 ---AGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQ--RVLYI . :: . .. ::. : :::..: .:.:. : ...: . :. ::: . CCDS14 LRLVDAVLGAEIRNGMAIIRPPG-HHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIV 200 210 220 230 240 250 180 190 200 210 220 230 pF1KE2 DIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPG--TGDLRDIGAGKGKYYAVNFPMR : :.:::.:.. .: :. :.:.: :...: ... : :.:. :..: : CCDS14 DWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWN 260 270 280 290 300 310 240 250 260 270 280 pF1KE2 D-GIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVV . :. : .: : .. : .::. :.. : :.:.:: : . : : :. .... CCDS14 QVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLL 320 330 340 350 360 370 290 300 310 320 330 340 pF1KE2 KTFNLPLLMLG-GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISP . :.:. :::..: .: CCDS14 MGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEA 380 390 400 410 420 430 >>CCDS83163.1 HDAC9 gene_id:9734|Hs108|chr7 (1025 aa) initn: 227 init1: 101 opt: 368 Z-score: 347.0 bits: 74.7 E(32554): 5.2e-13 Smith-Waterman score: 421; 27.5% identity (56.4% similar) in 411 aa overlap (29-402:613-1006) 10 20 30 40 50 pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPH :: . ::. . : . :: : : . . CCDS83 DRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGR 590 600 610 620 630 640 60 70 80 90 100 110 pF1KE2 KATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQM------QRFNVGEDCPVF--DGLFEF ::. ::. :: :. ..: . : . .. . .. :.: . : . :. . CCDS83 KASLEEIQLVHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIW 650 660 670 680 690 700 120 130 140 150 160 pF1KE2 CQLSTGGS----------VAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLA .: ..:. .:. : .. .. .:: : :::..: : :::. :..... CCDS83 NELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAIT 710 720 730 740 750 760 170 180 190 200 210 pF1KE2 ILELLKYH---QRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDI . :. . ...: .:.:.:::.:...:::. .. .:.:.: :..:::.: .. CCDS83 A-KYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEV 770 780 790 800 810 220 230 240 250 260 270 pF1KE2 GAGKGKYYAVNFPMRDGID----DESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDR :.: :. : .:. :.: : : . :. :.. : . ..:. :... : :.: : CCDS83 GTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHT 820 830 840 850 860 870 280 290 300 310 320 pF1KE2 --LGCFNLTVK--GH-AKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIP :: ...:.: :: .: . .. . : . :: : : : . :. : . . CCDS83 PPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLT----AICDASEACV--NALLG 880 890 900 910 920 930 330 340 350 360 370 380 pF1KE2 NELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRML--PHA---PGVQ ::: : .. :. :: :: ::. . . . .:... ....::. :.. :.: CCDS83 NEL------EPLAEDI-LHQSP-NMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQ 940 950 960 970 980 390 400 410 420 430 440 pF1KE2 MQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKG .: : . : : :.: CCDS83 LQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 990 1000 1010 1020 >>CCDS47554.1 HDAC9 gene_id:9734|Hs108|chr7 (1066 aa) initn: 227 init1: 101 opt: 368 Z-score: 346.7 bits: 74.7 E(32554): 5.4e-13 Smith-Waterman score: 421; 27.5% identity (56.4% similar) in 411 aa overlap (29-402:654-1047) 10 20 30 40 50 pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPH :: . ::. . : . :: : : . . CCDS47 DRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGR 630 640 650 660 670 680 60 70 80 90 100 110 pF1KE2 KATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQM------QRFNVGEDCPVF--DGLFEF ::. ::. :: :. ..: . : . .. . .. :.: . : . :. . CCDS47 KASLEEIQLVHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIW 690 700 710 720 730 740 120 130 140 150 160 pF1KE2 CQLSTGGS----------VAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLA .: ..:. .:. : .. .. .:: : :::..: : :::. :..... CCDS47 NELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAIT 750 760 770 780 790 800 170 180 190 200 210 pF1KE2 ILELLKYH---QRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDI . :. . ...: .:.:.:::.:...:::. .. .:.:.: :..:::.: .. CCDS47 A-KYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEV 810 820 830 840 850 860 220 230 240 250 260 270 pF1KE2 GAGKGKYYAVNFPMRDGID----DESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDR :.: :. : .:. :.: : : . :. :.. : . ..:. :... : :.: : CCDS47 GTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHT 870 880 890 900 910 920 280 290 300 310 320 pF1KE2 --LGCFNLTVK--GH-AKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIP :: ...:.: :: .: . .. . : . :: : : : . :. : . . CCDS47 PPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLT----AICDASEACV--NALLG 930 940 950 960 970 330 340 350 360 370 380 pF1KE2 NELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRML--PHA---PGVQ ::: : .. :. :: :: ::. . . . .:... ....::. :.. :.: CCDS47 NEL------EPLAEDI-LHQSP-NMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQ 980 990 1000 1010 1020 390 400 410 420 430 440 pF1KE2 MQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKG .: : . : : :.: CCDS47 LQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1030 1040 1050 1060 >>CCDS47553.1 HDAC9 gene_id:9734|Hs108|chr7 (1069 aa) initn: 227 init1: 101 opt: 368 Z-score: 346.7 bits: 74.7 E(32554): 5.4e-13 Smith-Waterman score: 421; 27.5% identity (56.4% similar) in 411 aa overlap (29-402:657-1050) 10 20 30 40 50 pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPH :: . ::. . : . :: : : . . CCDS47 DRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGR 630 640 650 660 670 680 60 70 80 90 100 110 pF1KE2 KATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQM------QRFNVGEDCPVF--DGLFEF ::. ::. :: :. ..: . : . .. . .. :.: . : . :. . CCDS47 KASLEEIQLVHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIW 690 700 710 720 730 740 120 130 140 150 160 pF1KE2 CQLSTGGS----------VAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLA .: ..:. .:. : .. .. .:: : :::..: : :::. :..... CCDS47 NELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAIT 750 760 770 780 790 800 170 180 190 200 210 pF1KE2 ILELLKYH---QRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDI . :. . ...: .:.:.:::.:...:::. .. .:.:.: :..:::.: .. CCDS47 A-KYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEV 810 820 830 840 850 860 220 230 240 250 260 270 pF1KE2 GAGKGKYYAVNFPMRDGID----DESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDR :.: :. : .:. :.: : : . :. :.. : . ..:. :... : :.: : CCDS47 GTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHT 870 880 890 900 910 920 280 290 300 310 320 pF1KE2 --LGCFNLTVK--GH-AKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIP :: ...:.: :: .: . .. . : . :: : : : . :. : . . CCDS47 PPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLT----AICDASEACV--NALLG 930 940 950 960 970 330 340 350 360 370 380 pF1KE2 NELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRML--PHA---PGVQ ::: : .. :. :: :: ::. . . . .:... ....::. :.. :.: CCDS47 NEL------EPLAEDI-LHQSP-NMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQ 980 990 1000 1010 1020 390 400 410 420 430 440 pF1KE2 MQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKG .: : . : : :.: CCDS47 LQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1030 1040 1050 1060 488 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 09:31:00 2016 done: Sun Nov 6 09:31:01 2016 Total Scan time: 2.920 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]