FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5568, 431 aa 1>>>pF1KE5568 431 - 431 aa - 431 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.6648+/-0.000383; mu= -1.9563+/- 0.024 mean_var=246.2413+/-50.161, 0's: 0 Z-trim(121.3): 22 B-trim: 598 in 1/56 Lambda= 0.081732 statistics sampled from 37784 (37806) to 37784 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.767), E-opt: 0.2 (0.443), width: 16 Scan time: 10.240 The best scores are: opt bits E(85289) NP_001002036 (OMIM: 608860) astacin-like metalloen ( 431) 2947 360.3 5.4e-99 XP_011509507 (OMIM: 608860) PREDICTED: astacin-lik ( 436) 2828 346.3 9.1e-95 XP_011509508 (OMIM: 608860) PREDICTED: astacin-lik ( 432) 2813 344.5 3.1e-94 XP_011509510 (OMIM: 608860) PREDICTED: astacin-lik ( 252) 1518 191.7 1.9e-48 XP_011509509 (OMIM: 608860) PREDICTED: astacin-lik ( 418) 1516 191.6 3.3e-48 NP_001295100 (OMIM: 600389) meprin A subunit beta ( 700) 464 67.7 1.1e-10 NP_005916 (OMIM: 600389) meprin A subunit beta iso ( 701) 464 67.7 1.1e-10 XP_011542919 (OMIM: 112264,614856) PREDICTED: bone ( 622) 446 65.5 4.3e-10 XP_016869227 (OMIM: 112264,614856) PREDICTED: bone ( 717) 446 65.6 4.8e-10 NP_001190 (OMIM: 112264,614856) bone morphogenetic ( 730) 446 65.6 4.9e-10 NP_036597 (OMIM: 606743) tolloid-like protein 2 pr (1015) 449 66.0 5e-10 XP_006716449 (OMIM: 112264,614856) PREDICTED: bone ( 813) 446 65.6 5.3e-10 NP_006120 (OMIM: 112264,614856) bone morphogenetic ( 986) 446 65.7 6.2e-10 NP_001191689 (OMIM: 606742,613087) tolloid-like pr ( 392) 435 64.1 7.3e-10 XP_016864059 (OMIM: 606742,613087) PREDICTED: toll ( 964) 435 64.4 1.5e-09 NP_036596 (OMIM: 606742,613087) tolloid-like prote (1013) 435 64.4 1.6e-09 XP_011512931 (OMIM: 600388) PREDICTED: meprin A su ( 705) 419 62.4 4.3e-09 NP_005579 (OMIM: 600388) meprin A subunit alpha pr ( 746) 419 62.4 4.5e-09 XP_011512930 (OMIM: 600388) PREDICTED: meprin A su ( 774) 419 62.4 4.6e-09 XP_011530516 (OMIM: 606742,613087) PREDICTED: toll ( 837) 397 59.8 3e-08 XP_011524316 (OMIM: 600389) PREDICTED: meprin A su ( 577) 317 50.3 1.5e-05 XP_011524315 (OMIM: 600389) PREDICTED: meprin A su ( 628) 315 50.1 1.9e-05 >>NP_001002036 (OMIM: 608860) astacin-like metalloendope (431 aa) initn: 2947 init1: 2947 opt: 2947 Z-score: 1898.2 bits: 360.3 E(85289): 5.4e-99 Smith-Waterman score: 2947; 99.5% identity (100.0% similar) in 431 aa overlap (1-431:1-431) 10 20 30 40 50 60 pF1KE5 MEGVGGLWPWVLGLLSLPGVILGAPLASSCAGACGTSFPDGLTPEGTQASGDKDIPAINQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEGVGGLWPWVLGLLSLPGVILGAPLASSCAGACGTSFPDGLTPEGTQASGDKDIPAINQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 GLILEETPESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEPSRQVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLILEETPESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEPSRQVI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 LEALAEFERSTCIRFVTYQDQRDFISIIPMYGCFSSVGRSGGMQVVSLAPTCLQKGRGIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEALAEFERSTCIRFVTYQDQRDFISIIPMYGCFSSVGRSGGMQVVSLAPTCLQKGRGIV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 LHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSRSSNMLTPYDYSSVMHYGR :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: NP_001 LHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSQSSNMLTPYDYSSVMHYGR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 LAFSRRGLPTITPLWAPSVHIGQRWNLSASDITRVLQLYGCSPSGPRPRGRGSHAHSTGR ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: NP_001 LAFSRRGLPTITPLWAPSVHIGQRWNLSASDITRVLKLYGCSPSGPRPRGRGSHAHSTGR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 SPAPASLSLQRLLEALSAESRSPDPSGSSAGGQPVPAGPGESPHGWESPALKKLSAEASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPAPASLSLQRLLEALSAESRSPDPSGSSAGGQPVPAGPGESPHGWESPALKKLSAEASA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 RQPQTLASSPRSRPGAGAPGVAQEQSWLAGVSTKPTVPSSEAGIQPVPVQGSPALPGGCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQPQTLASSPRSRPGAGAPGVAQEQSWLAGVSTKPTVPSSEAGIQPVPVQGSPALPGGCV 370 380 390 400 410 420 430 pF1KE5 PRNHFKGMSED ::::::::::: NP_001 PRNHFKGMSED 430 >>XP_011509507 (OMIM: 608860) PREDICTED: astacin-like me (436 aa) initn: 2828 init1: 2828 opt: 2828 Z-score: 1822.3 bits: 346.3 E(85289): 9.1e-95 Smith-Waterman score: 2828; 99.3% identity (99.8% similar) in 417 aa overlap (15-431:20-436) 10 20 30 40 50 pF1KE5 MEGVGGLWPWVLGLLSLPGVILGAPLASSCAGACGTSFPDGLTPEGTQASGDKDI :: :::::::::::::::::::::::::::::::::::::: XP_011 MSCCLVSPVGAPGICVCPCLSGPGVILGAPLASSCAGACGTSFPDGLTPEGTQASGDKDI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 PAINQGLILEETPESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAINQGLILEETPESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 SRQVILEALAEFERSTCIRFVTYQDQRDFISIIPMYGCFSSVGRSGGMQVVSLAPTCLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRQVILEALAEFERSTCIRFVTYQDQRDFISIIPMYGCFSSVGRSGGMQVVSLAPTCLQK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 GRGIVLHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSRSSNMLTPYDYSSV ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: XP_011 GRGIVLHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSQSSNMLTPYDYSSV 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 MHYGRLAFSRRGLPTITPLWAPSVHIGQRWNLSASDITRVLQLYGCSPSGPRPRGRGSHA :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: XP_011 MHYGRLAFSRRGLPTITPLWAPSVHIGQRWNLSASDITRVLKLYGCSPSGPRPRGRGSHA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE5 HSTGRSPAPASLSLQRLLEALSAESRSPDPSGSSAGGQPVPAGPGESPHGWESPALKKLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSTGRSPAPASLSLQRLLEALSAESRSPDPSGSSAGGQPVPAGPGESPHGWESPALKKLS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE5 AEASARQPQTLASSPRSRPGAGAPGVAQEQSWLAGVSTKPTVPSSEAGIQPVPVQGSPAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEASARQPQTLASSPRSRPGAGAPGVAQEQSWLAGVSTKPTVPSSEAGIQPVPVQGSPAL 370 380 390 400 410 420 420 430 pF1KE5 PGGCVPRNHFKGMSED :::::::::::::::: XP_011 PGGCVPRNHFKGMSED 430 >>XP_011509508 (OMIM: 608860) PREDICTED: astacin-like me (432 aa) initn: 2812 init1: 2812 opt: 2813 Z-score: 1812.8 bits: 344.5 E(85289): 3.1e-94 Smith-Waterman score: 2813; 98.3% identity (99.0% similar) in 420 aa overlap (12-431:13-432) 10 20 30 40 50 pF1KE5 MEGVGGLWPWVLGLLSLPGVILGAPLASSCAGACGTSFPDGLTPEGTQASGDKDIPAIN : :. ::::::::::::::::::::::::::::::::::::::::: XP_011 MGPSSLRKTSSGLPLILHYGVILGAPLASSCAGACGTSFPDGLTPEGTQASGDKDIPAIN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 QGLILEETPESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEPSRQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGLILEETPESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEPSRQV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 ILEALAEFERSTCIRFVTYQDQRDFISIIPMYGCFSSVGRSGGMQVVSLAPTCLQKGRGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILEALAEFERSTCIRFVTYQDQRDFISIIPMYGCFSSVGRSGGMQVVSLAPTCLQKGRGI 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 VLHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSRSSNMLTPYDYSSVMHYG ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: XP_011 VLHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSQSSNMLTPYDYSSVMHYG 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 RLAFSRRGLPTITPLWAPSVHIGQRWNLSASDITRVLQLYGCSPSGPRPRGRGSHAHSTG :::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::: XP_011 RLAFSRRGLPTITPLWAPSVHIGQRWNLSASDITRVLKLYGCSPSGPRPRGRGSHAHSTG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE5 RSPAPASLSLQRLLEALSAESRSPDPSGSSAGGQPVPAGPGESPHGWESPALKKLSAEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSPAPASLSLQRLLEALSAESRSPDPSGSSAGGQPVPAGPGESPHGWESPALKKLSAEAS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE5 ARQPQTLASSPRSRPGAGAPGVAQEQSWLAGVSTKPTVPSSEAGIQPVPVQGSPALPGGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARQPQTLASSPRSRPGAGAPGVAQEQSWLAGVSTKPTVPSSEAGIQPVPVQGSPALPGGC 370 380 390 400 410 420 420 430 pF1KE5 VPRNHFKGMSED :::::::::::: XP_011 VPRNHFKGMSED 430 >>XP_011509510 (OMIM: 608860) PREDICTED: astacin-like me (252 aa) initn: 1518 init1: 1518 opt: 1518 Z-score: 990.9 bits: 191.7 E(85289): 1.9e-48 Smith-Waterman score: 1518; 98.7% identity (99.6% similar) in 227 aa overlap (15-241:20-246) 10 20 30 40 50 pF1KE5 MEGVGGLWPWVLGLLSLPGVILGAPLASSCAGACGTSFPDGLTPEGTQASGDKDI :: :::::::::::::::::::::::::::::::::::::: XP_011 MSCCLVSPVGAPGICVCPCLSGPGVILGAPLASSCAGACGTSFPDGLTPEGTQASGDKDI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 PAINQGLILEETPESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAINQGLILEETPESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 SRQVILEALAEFERSTCIRFVTYQDQRDFISIIPMYGCFSSVGRSGGMQVVSLAPTCLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRQVILEALAEFERSTCIRFVTYQDQRDFISIIPMYGCFSSVGRSGGMQVVSLAPTCLQK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 GRGIVLHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSRSSNMLTPYDYSSV ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: XP_011 GRGIVLHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSQSSNMLTPYDYSSV 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 MHYGRLAFSRRGLPTITPLWAPSVHIGQRWNLSASDITRVLQLYGCSPSGPRPRGRGSHA :::::. XP_011 MHYGRVPCPQHW 250 >>XP_011509509 (OMIM: 608860) PREDICTED: astacin-like me (418 aa) initn: 1589 init1: 1516 opt: 1516 Z-score: 986.5 bits: 191.6 E(85289): 3.3e-48 Smith-Waterman score: 2655; 95.0% identity (95.4% similar) in 417 aa overlap (15-431:20-418) 10 20 30 40 50 pF1KE5 MEGVGGLWPWVLGLLSLPGVILGAPLASSCAGACGTSFPDGLTPEGTQASGDKDI :: :::::::::::::::::::::::::::::::::::::: XP_011 MSCCLVSPVGAPGICVCPCLSGPGVILGAPLASSCAGACGTSFPDGLTPEGTQASGDKDI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 PAINQGLILEETPESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAINQGLILEETPESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 SRQVILEALAEFERSTCIRFVTYQDQRDFISIIPMYGCFSSVGRSGGMQVVSLAPTCLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRQVILEALAEFERSTCIRFVTYQDQRDFISIIPMYGCFSSVGRSGGMQVVSLAPTCLQK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 GRGIVLHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSRSSNMLTPYDYSSV ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: XP_011 GRGIVLHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSQSSNMLTPYDYSSV 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 MHYGRLAFSRRGLPTITPLWAPSVHIGQRWNLSASDITRVLQLYGCSPSGPRPRGRGSHA :::: :::::::::::::::::::.:::::::::::::::::: XP_011 MHYG------------------SVHIGQRWNLSASDITRVLKLYGCSPSGPRPRGRGSHA 250 260 270 280 300 310 320 330 340 350 pF1KE5 HSTGRSPAPASLSLQRLLEALSAESRSPDPSGSSAGGQPVPAGPGESPHGWESPALKKLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSTGRSPAPASLSLQRLLEALSAESRSPDPSGSSAGGQPVPAGPGESPHGWESPALKKLS 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE5 AEASARQPQTLASSPRSRPGAGAPGVAQEQSWLAGVSTKPTVPSSEAGIQPVPVQGSPAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEASARQPQTLASSPRSRPGAGAPGVAQEQSWLAGVSTKPTVPSSEAGIQPVPVQGSPAL 350 360 370 380 390 400 420 430 pF1KE5 PGGCVPRNHFKGMSED :::::::::::::::: XP_011 PGGCVPRNHFKGMSED 410 >>NP_001295100 (OMIM: 600389) meprin A subunit beta isof (700 aa) initn: 462 init1: 186 opt: 464 Z-score: 312.9 bits: 67.7 E(85289): 1.1e-10 Smith-Waterman score: 501; 37.8% identity (63.8% similar) in 254 aa overlap (41-284:20-258) 20 30 40 50 60 pF1KE5 VLGLLSLPGVILGAPLASSCAGACGTSFPDGL-TPEGTQASG--DKDIPAINQGLILEET :: :::. ...: :.:: ::.:: :. NP_001 MDLWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLD-- 10 20 30 40 70 80 90 100 110 120 pF1KE5 PESSFLIEGDII--RPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEPSRQVILEALA :.:::: : . . . . .:: .:..: .. . .. :::.:. NP_001 -----LFEGDIRLDRAQIRNSIIGEKYRWPH------TIPYVLEDSLEMNAKGVILNAFE 50 60 70 80 90 130 140 150 160 170 180 pF1KE5 EFERSTCIRFVTYQDQRDFISIIPMYGCFSSVG-RSGGMQVVSLAPTCLQKGRGIVLHEL ... .::: : . . ..::.. ::.:::: : : : .:.. .: . . : ::. NP_001 RYRLKTCIDFKPWAGETNYISVFKGSGCWSSVGNRRVGKQELSIGANCDRIAT--VQHEF 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE5 MHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSR---SSNMLTPYDYSSVMHYGRL .:.::::::..:.::: :.:. :..:: : : :: :... .::::.:::::.. NP_001 LHALGFWHEQSRSDRDDYVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKT 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE5 AFSRRGLPTITPLWAPSVH-IGQRWNLSASDITRVLQLYGCSPSGPRPRGRGSHAHSTGR ::. :::. . :::: ..: ::. .. :::.:: : NP_001 AFQNGTEPTIVTRISDFEDVIGQRMDFSDSDLLKLNQLYNCSSSLSFMDSCSFELENVCG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE5 SPAPASLSLQRLLEALSAESRSPDPSGSSAGGQPVPAGPGESPHGWESPALKKLSAEASA NP_001 MIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYP 280 290 300 310 320 330 >>NP_005916 (OMIM: 600389) meprin A subunit beta isoform (701 aa) initn: 462 init1: 186 opt: 464 Z-score: 312.9 bits: 67.7 E(85289): 1.1e-10 Smith-Waterman score: 501; 37.8% identity (63.8% similar) in 254 aa overlap (41-284:20-258) 20 30 40 50 60 pF1KE5 VLGLLSLPGVILGAPLASSCAGACGTSFPDGL-TPEGTQASG--DKDIPAINQGLILEET :: :::. ...: :.:: ::.:: :. NP_005 MDLWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLD-- 10 20 30 40 70 80 90 100 110 120 pF1KE5 PESSFLIEGDII--RPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEPSRQVILEALA :.:::: : . . . . .:: .:..: .. . .. :::.:. NP_005 -----LFEGDIRLDRAQIRNSIIGEKYRWPH------TIPYVLEDSLEMNAKGVILNAFE 50 60 70 80 90 130 140 150 160 170 180 pF1KE5 EFERSTCIRFVTYQDQRDFISIIPMYGCFSSVG-RSGGMQVVSLAPTCLQKGRGIVLHEL ... .::: : . . ..::.. ::.:::: : : : .:.. .: . . : ::. NP_005 RYRLKTCIDFKPWAGETNYISVFKGSGCWSSVGNRRVGKQELSIGANCDRIAT--VQHEF 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE5 MHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSR---SSNMLTPYDYSSVMHYGRL .:.::::::..:.::: :.:. :..:: : : :: :... .::::.:::::.. NP_005 LHALGFWHEQSRSDRDDYVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKT 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE5 AFSRRGLPTITPLWAPSVH-IGQRWNLSASDITRVLQLYGCSPSGPRPRGRGSHAHSTGR ::. :::. . :::: ..: ::. .. :::.:: : NP_005 AFQNGTEPTIVTRISDFEDVIGQRMDFSDSDLLKLNQLYNCSSSLSFMDSCSFELENVCG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE5 SPAPASLSLQRLLEALSAESRSPDPSGSSAGGQPVPAGPGESPHGWESPALKKLSAEASA NP_005 MIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYP 280 290 300 310 320 330 >>XP_011542919 (OMIM: 112264,614856) PREDICTED: bone mor (622 aa) initn: 398 init1: 245 opt: 446 Z-score: 302.2 bits: 65.5 E(85289): 4.3e-10 Smith-Waterman score: 449; 38.1% identity (64.1% similar) in 231 aa overlap (94-300:130-351) 70 80 90 100 110 120 pF1KE5 LEETPESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEPSRQVILEA :: .::. ::...... .: :. .: XP_011 TNGQPQRGACGRWRGRSRSRRAATSRPERVWP---DGVI--PFVIGGNFTGSQRAVFRQA 100 110 120 130 140 150 130 140 150 160 170 180 pF1KE5 LAEFERSTCIRFVTYQDQRDFISII--PMYGCFSSVGR-SGGMQVVSLAPTCLQKGRGIV . ..:. ::. :. :. ..: . : :: : ::: .:: :..:.. .: . ::: XP_011 MRHWEKHTCVTFLERTDEDSYIVFTYRPC-GCCSYVGRRGGGPQAISIGKNCDK--FGIV 160 170 180 190 200 210 190 200 210 220 230 pF1KE5 LHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSRSSNMLT---PYDYSSVMH .::: ::.:::::::: ::::.. . ..: :: : ::.: . ... . ::..:.:: XP_011 VHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMH 220 230 240 250 260 270 240 250 260 270 280 pF1KE5 YGRLAFSRRG--LPTITPLW-APSVH--IGQRWNLSASDITRVLQLYGCSPSG------- :.: .::: : : ::.: . . .:. :::: :: .::... .:: : : XP_011 YARNTFSR-GIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDST 280 290 300 310 320 330 290 300 310 320 330 pF1KE5 -----PR-PRGRGSHAHSTGRSPAPASLSLQRLLEALSAESRSPDPSGSSAGGQPVPAGP :. : : ..: : . : XP_011 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 340 350 360 370 380 390 >>XP_016869227 (OMIM: 112264,614856) PREDICTED: bone mor (717 aa) initn: 398 init1: 245 opt: 446 Z-score: 301.3 bits: 65.6 E(85289): 4.8e-10 Smith-Waterman score: 449; 38.1% identity (64.1% similar) in 231 aa overlap (94-300:130-351) 70 80 90 100 110 120 pF1KE5 LEETPESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEPSRQVILEA :: .::. ::...... .: :. .: XP_016 TNGQPQRGACGRWRGRSRSRRAATSRPERVWP---DGVI--PFVIGGNFTGSQRAVFRQA 100 110 120 130 140 150 130 140 150 160 170 180 pF1KE5 LAEFERSTCIRFVTYQDQRDFISII--PMYGCFSSVGR-SGGMQVVSLAPTCLQKGRGIV . ..:. ::. :. :. ..: . : :: : ::: .:: :..:.. .: . ::: XP_016 MRHWEKHTCVTFLERTDEDSYIVFTYRPC-GCCSYVGRRGGGPQAISIGKNCDK--FGIV 160 170 180 190 200 210 190 200 210 220 230 pF1KE5 LHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSRSSNMLT---PYDYSSVMH .::: ::.:::::::: ::::.. . ..: :: : ::.: . ... . ::..:.:: XP_016 VHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMH 220 230 240 250 260 270 240 250 260 270 280 pF1KE5 YGRLAFSRRG--LPTITPLW-APSVH--IGQRWNLSASDITRVLQLYGCSPSG------- :.: .::: : : ::.: . . .:. :::: :: .::... .:: : : XP_016 YARNTFSR-GIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDST 280 290 300 310 320 330 290 300 310 320 330 pF1KE5 -----PR-PRGRGSHAHSTGRSPAPASLSLQRLLEALSAESRSPDPSGSSAGGQPVPAGP :. : : ..: : . : XP_016 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 340 350 360 370 380 390 >>NP_001190 (OMIM: 112264,614856) bone morphogenetic pro (730 aa) initn: 398 init1: 245 opt: 446 Z-score: 301.2 bits: 65.6 E(85289): 4.9e-10 Smith-Waterman score: 449; 38.1% identity (64.1% similar) in 231 aa overlap (94-300:130-351) 70 80 90 100 110 120 pF1KE5 LEETPESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEPSRQVILEA :: .::. ::...... .: :. .: NP_001 TNGQPQRGACGRWRGRSRSRRAATSRPERVWP---DGVI--PFVIGGNFTGSQRAVFRQA 100 110 120 130 140 150 130 140 150 160 170 180 pF1KE5 LAEFERSTCIRFVTYQDQRDFISII--PMYGCFSSVGR-SGGMQVVSLAPTCLQKGRGIV . ..:. ::. :. :. ..: . : :: : ::: .:: :..:.. .: . ::: NP_001 MRHWEKHTCVTFLERTDEDSYIVFTYRPC-GCCSYVGRRGGGPQAISIGKNCDK--FGIV 160 170 180 190 200 210 190 200 210 220 230 pF1KE5 LHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSRSSNMLT---PYDYSSVMH .::: ::.:::::::: ::::.. . ..: :: : ::.: . ... . ::..:.:: NP_001 VHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMH 220 230 240 250 260 270 240 250 260 270 280 pF1KE5 YGRLAFSRRG--LPTITPLW-APSVH--IGQRWNLSASDITRVLQLYGCSPSG------- :.: .::: : : ::.: . . .:. :::: :: .::... .:: : : NP_001 YARNTFSR-GIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDST 280 290 300 310 320 330 290 300 310 320 330 pF1KE5 -----PR-PRGRGSHAHSTGRSPAPASLSLQRLLEALSAESRSPDPSGSSAGGQPVPAGP :. : : ..: : . : NP_001 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 340 350 360 370 380 390 431 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 01:55:10 2016 done: Tue Nov 8 01:55:11 2016 Total Scan time: 10.240 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]