FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5635, 527 aa 1>>>pF1KE5635 527 - 527 aa - 527 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0090+/-0.000411; mu= 14.9729+/- 0.026 mean_var=84.1352+/-16.755, 0's: 0 Z-trim(112.0): 31 B-trim: 0 in 0/54 Lambda= 0.139825 statistics sampled from 20773 (20802) to 20773 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.244), width: 16 Scan time: 8.640 The best scores are: opt bits E(85289) NP_997657 (OMIM: 601934) COP9 signalosome complex ( 527) 3424 701.0 2.2e-201 NP_001308019 (OMIM: 601934) COP9 signalosome compl ( 555) 3424 701.1 2.3e-201 NP_001308018 (OMIM: 601934) COP9 signalosome compl ( 559) 3406 697.4 2.8e-200 NP_001308020 (OMIM: 601934) COP9 signalosome compl ( 554) 3405 697.2 3.3e-200 XP_005256410 (OMIM: 601934) PREDICTED: COP9 signal ( 581) 3275 671.0 2.7e-192 XP_005256407 (OMIM: 601934) PREDICTED: COP9 signal ( 585) 3257 667.4 3.3e-191 XP_016880014 (OMIM: 601934) PREDICTED: COP9 signal ( 580) 3256 667.2 3.8e-191 NP_001308021 (OMIM: 601934) COP9 signalosome compl ( 487) 3101 635.9 8.4e-182 NP_004118 (OMIM: 601934) COP9 signalosome complex ( 491) 3083 632.2 1.1e-180 NP_001317468 (OMIM: 601934) COP9 signalosome compl ( 486) 3082 632.0 1.2e-180 NP_001308022 (OMIM: 601934) COP9 signalosome compl ( 471) 3065 628.6 1.3e-179 NP_001317470 (OMIM: 601934) COP9 signalosome compl ( 490) 3064 628.4 1.5e-179 XP_016880023 (OMIM: 601934) PREDICTED: COP9 signal ( 475) 3047 625.0 1.6e-178 XP_016880024 (OMIM: 601934) PREDICTED: COP9 signal ( 470) 3046 624.8 1.8e-178 XP_016880015 (OMIM: 601934) PREDICTED: COP9 signal ( 474) 3028 621.1 2.2e-177 XP_005256417 (OMIM: 601934) PREDICTED: COP9 signal ( 513) 2952 605.8 9.8e-173 XP_005256416 (OMIM: 601934) PREDICTED: COP9 signal ( 517) 2934 602.2 1.2e-171 XP_016880016 (OMIM: 601934) PREDICTED: COP9 signal ( 512) 2933 602.0 1.4e-171 XP_011521872 (OMIM: 601934) PREDICTED: COP9 signal ( 497) 2916 598.6 1.5e-170 XP_016880019 (OMIM: 601934) PREDICTED: COP9 signal ( 497) 2916 598.6 1.5e-170 XP_011521871 (OMIM: 601934) PREDICTED: COP9 signal ( 501) 2898 594.9 1.8e-169 XP_016880017 (OMIM: 601934) PREDICTED: COP9 signal ( 501) 2898 594.9 1.8e-169 XP_016880020 (OMIM: 601934) PREDICTED: COP9 signal ( 496) 2897 594.7 2.1e-169 XP_016880018 (OMIM: 601934) PREDICTED: COP9 signal ( 500) 2879 591.1 2.6e-168 XP_016880013 (OMIM: 601934) PREDICTED: COP9 signal ( 500) 2879 591.1 2.6e-168 >>NP_997657 (OMIM: 601934) COP9 signalosome complex subu (527 aa) initn: 3424 init1: 3424 opt: 3424 Z-score: 3736.5 bits: 701.0 E(85289): 2.2e-201 Smith-Waterman score: 3424; 100.0% identity (100.0% similar) in 527 aa overlap (1-527:1-527) 10 20 30 40 50 60 pF1KE5 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPGTAGDFSLSASLSACTLLYEGAVEPMQID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPGTAGDFSLSASLSACTLLYEGAVEPMQID 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 VDPQEDPQNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 VDPQEDPQNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 FVQRTFNVDMYEEIHRKLSEATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 FVQRTFNVDMYEEIHRKLSEATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 LDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 LDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 VIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 VIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 QAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 QAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 QVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 QVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 DMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 DMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGK 430 440 450 460 470 480 490 500 510 520 pF1KE5 EFQRRAKAMMLRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM ::::::::::::::::::::::::::::::::::::::::::::::: NP_997 EFQRRAKAMMLRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM 490 500 510 520 >>NP_001308019 (OMIM: 601934) COP9 signalosome complex s (555 aa) initn: 3424 init1: 3424 opt: 3424 Z-score: 3736.2 bits: 701.1 E(85289): 2.3e-201 Smith-Waterman score: 3424; 100.0% identity (100.0% similar) in 527 aa overlap (1-527:29-555) 10 20 30 pF1KE5 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG :::::::::::::::::::::::::::::::: NP_001 MPLPVQVFNLQQPASSVSGSGGAESQDRMRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE5 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE5 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE5 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRG 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE5 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE5 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE5 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE5 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQG 490 500 510 520 530 540 520 pF1KE5 ELTPANSQSRMSTNM ::::::::::::::: NP_001 ELTPANSQSRMSTNM 550 >>NP_001308018 (OMIM: 601934) COP9 signalosome complex s (559 aa) initn: 2503 init1: 2503 opt: 3406 Z-score: 3716.5 bits: 697.4 E(85289): 2.8e-200 Smith-Waterman score: 3406; 99.2% identity (99.2% similar) in 531 aa overlap (1-527:29-559) 10 20 30 pF1KE5 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG :::::::::::::::::::::::::::::::: NP_001 MPLPVQVFNLQQPASSVSGSGGAESQDRMRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS 70 80 90 100 110 120 100 110 120 130 140 pF1KE5 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATR----ELQNA ::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: NP_001 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRSSLRELQNA 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE5 PDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHY 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE5 LDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIA 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE5 EQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIY 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE5 GGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNL 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE5 LLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGL 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE5 ISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPRE 490 500 510 520 530 540 510 520 pF1KE5 GSQGELTPANSQSRMSTNM ::::::::::::::::::: NP_001 GSQGELTPANSQSRMSTNM 550 >>NP_001308020 (OMIM: 601934) COP9 signalosome complex s (554 aa) initn: 1773 init1: 1773 opt: 3405 Z-score: 3715.5 bits: 697.2 E(85289): 3.3e-200 Smith-Waterman score: 3405; 99.8% identity (99.8% similar) in 527 aa overlap (1-527:29-554) 10 20 30 pF1KE5 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG :::::::::::::::::::::::::::::::: NP_001 MPLPVQVFNLQQPASSVSGSGGAESQDRMRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE5 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE5 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE5 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: NP_001 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAE-RG 250 260 270 280 290 280 290 300 310 320 330 pF1KE5 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE5 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE5 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE5 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQG 480 490 500 510 520 530 520 pF1KE5 ELTPANSQSRMSTNM ::::::::::::::: NP_001 ELTPANSQSRMSTNM 540 550 >>XP_005256410 (OMIM: 601934) PREDICTED: COP9 signalosom (581 aa) initn: 3275 init1: 3275 opt: 3275 Z-score: 3573.4 bits: 671.0 E(85289): 2.7e-192 Smith-Waterman score: 3362; 95.3% identity (95.3% similar) in 553 aa overlap (1-527:29-581) 10 20 30 pF1KE5 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG :::::::::::::::::::::::::::::::: XP_005 MPLPVQVFNLQQPASSVSGSGGAESQDRMRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE5 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE5 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE5 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRG 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE5 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE5 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE5 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR 430 440 450 460 470 480 460 470 480 490 500 pF1KE5 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVK--------- ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKVGWLEGGQA 490 500 510 520 530 540 510 520 pF1KE5 -----------------SPPREGSQGELTPANSQSRMSTNM :::::::::::::::::::::::: XP_005 HGVWGLVAVSCSLSPLQSPPREGSQGELTPANSQSRMSTNM 550 560 570 580 >>XP_005256407 (OMIM: 601934) PREDICTED: COP9 signalosom (585 aa) initn: 3272 init1: 2354 opt: 3257 Z-score: 3553.8 bits: 667.4 E(85289): 3.3e-191 Smith-Waterman score: 3344; 94.6% identity (94.6% similar) in 557 aa overlap (1-527:29-585) 10 20 30 pF1KE5 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG :::::::::::::::::::::::::::::::: XP_005 MPLPVQVFNLQQPASSVSGSGGAESQDRMRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS 70 80 90 100 110 120 100 110 120 130 140 pF1KE5 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATR----ELQNA ::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: XP_005 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRSSLRELQNA 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE5 PDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHY 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE5 LDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIA 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE5 EQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIY 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE5 GGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNL 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE5 LLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGL 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE5 ISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVK----- ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKVGWLE 490 500 510 520 530 540 510 520 pF1KE5 ---------------------SPPREGSQGELTPANSQSRMSTNM :::::::::::::::::::::::: XP_005 GGQAHGVWGLVAVSCSLSPLQSPPREGSQGELTPANSQSRMSTNM 550 560 570 580 >>XP_016880014 (OMIM: 601934) PREDICTED: COP9 signalosom (580 aa) initn: 3255 init1: 1773 opt: 3256 Z-score: 3552.7 bits: 667.2 E(85289): 3.8e-191 Smith-Waterman score: 3343; 95.1% identity (95.1% similar) in 553 aa overlap (1-527:29-580) 10 20 30 pF1KE5 MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG :::::::::::::::::::::::::::::::: XP_016 MPLPVQVFNLQQPASSVSGSGGAESQDRMRDSSAPSSASSSVTDLYCTPHSSRSDLVLPG 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE5 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAI 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE5 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCG 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE5 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_016 DLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAE-RG 250 260 270 280 290 280 290 300 310 320 330 pF1KE5 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLC 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE5 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDM 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE5 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISAR 420 430 440 450 460 470 460 470 480 490 500 pF1KE5 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVK--------- ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKVGWLEGGQA 480 490 500 510 520 530 510 520 pF1KE5 -----------------SPPREGSQGELTPANSQSRMSTNM :::::::::::::::::::::::: XP_016 HGVWGLVAVSCSLSPLQSPPREGSQGELTPANSQSRMSTNM 540 550 560 570 580 >>NP_001308021 (OMIM: 601934) COP9 signalosome complex s (487 aa) initn: 3101 init1: 3101 opt: 3101 Z-score: 3384.9 bits: 635.9 E(85289): 8.4e-182 Smith-Waterman score: 3101; 99.8% identity (100.0% similar) in 477 aa overlap (51-527:11-487) 30 40 50 60 70 80 pF1KE5 PHSSRSDLVLPGTAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENP .::::::::::::::::::::::::::::: NP_001 MPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENP 10 20 30 40 90 100 110 120 130 140 pF1KE5 SLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSE 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE5 ATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRG 110 120 130 140 150 160 210 220 230 240 250 260 pF1KE5 HDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSK 170 180 190 200 210 220 270 280 290 300 310 320 pF1KE5 AESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELL 230 240 250 260 270 280 330 340 350 360 370 380 pF1KE5 SPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKM 290 300 310 320 330 340 390 400 410 420 430 440 pF1KE5 LDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDEL 350 360 370 380 390 400 450 460 470 480 490 500 pF1KE5 TQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQI 410 420 430 440 450 460 510 520 pF1KE5 HVKSPPREGSQGELTPANSQSRMSTNM ::::::::::::::::::::::::::: NP_001 HVKSPPREGSQGELTPANSQSRMSTNM 470 480 >>NP_004118 (OMIM: 601934) COP9 signalosome complex subu (491 aa) initn: 2499 init1: 2499 opt: 3083 Z-score: 3365.2 bits: 632.2 E(85289): 1.1e-180 Smith-Waterman score: 3083; 99.0% identity (99.2% similar) in 481 aa overlap (51-527:11-491) 30 40 50 60 70 80 pF1KE5 PHSSRSDLVLPGTAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENP .::::::::::::::::::::::::::::: NP_004 MPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENP 10 20 30 40 90 100 110 120 130 140 pF1KE5 SLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSE 50 60 70 80 90 100 150 160 170 180 190 pF1KE5 ATR----ELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKES ::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ATRSSLRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKES 110 120 130 140 150 160 200 210 220 230 240 250 pF1KE5 IRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLS 170 180 190 200 210 220 260 270 280 290 300 310 pF1KE5 YVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDF 230 240 250 260 270 280 320 330 340 350 360 370 pF1KE5 PELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYAS 290 300 310 320 330 340 380 390 400 410 420 430 pF1KE5 CLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAAL 350 360 370 380 390 400 440 450 460 470 480 490 pF1KE5 EDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVL 410 420 430 440 450 460 500 510 520 pF1KE5 RNQIHVKSPPREGSQGELTPANSQSRMSTNM ::::::::::::::::::::::::::::::: NP_004 RNQIHVKSPPREGSQGELTPANSQSRMSTNM 470 480 490 >>NP_001317468 (OMIM: 601934) COP9 signalosome complex s (486 aa) initn: 1671 init1: 1647 opt: 3082 Z-score: 3364.2 bits: 632.0 E(85289): 1.2e-180 Smith-Waterman score: 3082; 99.6% identity (99.8% similar) in 477 aa overlap (51-527:11-486) 30 40 50 60 70 80 pF1KE5 PHSSRSDLVLPGTAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENP .::::::::::::::::::::::::::::: NP_001 MPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENP 10 20 30 40 90 100 110 120 130 140 pF1KE5 SLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSE 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE5 ATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRG 110 120 130 140 150 160 210 220 230 240 250 260 pF1KE5 HDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSK 170 180 190 200 210 220 270 280 290 300 310 320 pF1KE5 AESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELL ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AESTPEIAE-RGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELL 230 240 250 260 270 330 340 350 360 370 380 pF1KE5 SPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKM 280 290 300 310 320 330 390 400 410 420 430 440 pF1KE5 LDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDEL 340 350 360 370 380 390 450 460 470 480 490 500 pF1KE5 TQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQI 400 410 420 430 440 450 510 520 pF1KE5 HVKSPPREGSQGELTPANSQSRMSTNM ::::::::::::::::::::::::::: NP_001 HVKSPPREGSQGELTPANSQSRMSTNM 460 470 480 527 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:24:00 2016 done: Tue Nov 8 05:24:02 2016 Total Scan time: 8.640 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]