FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4307, 312 aa 1>>>pF1KE4307 312 - 312 aa - 312 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2344+/-0.000332; mu= 16.7247+/- 0.021 mean_var=70.4101+/-14.040, 0's: 0 Z-trim(116.1): 73 B-trim: 858 in 1/55 Lambda= 0.152847 statistics sampled from 26929 (27002) to 26929 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.699), E-opt: 0.2 (0.317), width: 16 Scan time: 6.800 The best scores are: opt bits E(85289) NP_000708 (OMIM: 114760,600852) carbonic anhydrase ( 312) 2102 472.3 5.7e-133 XP_016880501 (OMIM: 114760,600852) PREDICTED: carb ( 222) 1483 335.7 5.3e-92 XP_005257696 (OMIM: 114760,600852) PREDICTED: carb ( 336) 1169 266.5 5.2e-71 XP_011523485 (OMIM: 114760,600852) PREDICTED: carb ( 246) 945 217.1 3e-56 NP_996808 (OMIM: 143860,603263) carbonic anhydrase ( 343) 518 123.0 8.6e-28 NP_001209 (OMIM: 143860,603263) carbonic anhydrase ( 354) 502 119.5 1e-26 XP_005245116 (OMIM: 604832) PREDICTED: carbonic an ( 336) 497 118.4 2.1e-26 NP_036245 (OMIM: 604832) carbonic anhydrase 14 pre ( 337) 495 117.9 2.8e-26 XP_006711322 (OMIM: 604832) PREDICTED: carbonic an ( 318) 492 117.2 4.3e-26 XP_011540385 (OMIM: 114780) PREDICTED: carbonic an ( 294) 490 116.8 5.5e-26 NP_001206 (OMIM: 114780) carbonic anhydrase 6 isof ( 308) 490 116.8 5.7e-26 NP_001257429 (OMIM: 114780) carbonic anhydrase 6 i ( 313) 490 116.8 5.8e-26 XP_005245117 (OMIM: 604832) PREDICTED: carbonic an ( 319) 490 116.8 5.9e-26 XP_011540386 (OMIM: 114780) PREDICTED: carbonic an ( 324) 490 116.8 5.9e-26 NP_005173 (OMIM: 114770) carbonic anhydrase 7 isof ( 264) 468 111.9 1.5e-24 XP_005265410 (OMIM: 176886) PREDICTED: receptor-ty (1416) 464 111.5 1e-23 NP_002832 (OMIM: 176886) receptor-type tyrosine-pr (1445) 464 111.5 1e-23 NP_000058 (OMIM: 259730,611492) carbonic anhydrase ( 260) 451 108.1 1.9e-23 XP_006711324 (OMIM: 604832) PREDICTED: carbonic an ( 281) 430 103.5 5.1e-22 NP_005172 (OMIM: 114750) carbonic anhydrase 3 [Hom ( 260) 427 102.9 7.6e-22 XP_016856382 (OMIM: 604832) PREDICTED: carbonic an ( 263) 425 102.4 1e-21 NP_001280571 (OMIM: 143860,603263) carbonic anhydr ( 283) 424 102.2 1.3e-21 XP_011507681 (OMIM: 604832) PREDICTED: carbonic an ( 323) 423 102.0 1.7e-21 NP_940986 (OMIM: 611436) carbonic anhydrase 13 [Ho ( 262) 418 100.9 3e-21 XP_011521613 (OMIM: 114770) PREDICTED: carbonic an ( 242) 415 100.2 4.5e-21 XP_016884736 (OMIM: 300230) PREDICTED: carbonic an ( 278) 408 98.7 1.5e-20 XP_005274499 (OMIM: 300230) PREDICTED: carbonic an ( 317) 408 98.7 1.6e-20 NP_009151 (OMIM: 300230) carbonic anhydrase 5B, mi ( 317) 408 98.7 1.6e-20 NP_004047 (OMIM: 114815,613227) carbonic anhydrase ( 290) 398 96.5 6.9e-20 NP_001308766 (OMIM: 114815,613227) carbonic anhydr ( 290) 398 96.5 6.9e-20 XP_011521614 (OMIM: 114770) PREDICTED: carbonic an ( 208) 391 94.8 1.6e-19 XP_005256193 (OMIM: 114770) PREDICTED: carbonic an ( 208) 391 94.8 1.6e-19 NP_001014435 (OMIM: 114770) carbonic anhydrase 7 i ( 208) 391 94.8 1.6e-19 NP_001207 (OMIM: 603179) carbonic anhydrase 9 prec ( 459) 394 95.7 1.8e-19 NP_001730 (OMIM: 114761,615751) carbonic anhydrase ( 305) 390 94.7 2.5e-19 NP_001193768 (OMIM: 176891,600263) receptor-type t (1448) 391 95.4 7.3e-19 NP_001193767 (OMIM: 176891,600263) receptor-type t (1455) 391 95.4 7.4e-19 NP_001122301 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 380 92.5 1e-18 NP_001729 (OMIM: 114800) carbonic anhydrase 1 isof ( 261) 380 92.5 1e-18 NP_001122302 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 380 92.5 1e-18 NP_001122303 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 380 92.5 1e-18 NP_001158302 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 380 92.5 1e-18 XP_016867966 (OMIM: 176891,600263) PREDICTED: rece (2301) 391 95.5 1.1e-18 XP_005250576 (OMIM: 176891,600263) PREDICTED: rece (2308) 391 95.5 1.1e-18 NP_002842 (OMIM: 176891,600263) receptor-type tyro (2315) 391 95.5 1.1e-18 XP_016862453 (OMIM: 176886) PREDICTED: receptor-ty (1329) 383 93.6 2.3e-18 NP_001257430 (OMIM: 114780) carbonic anhydrase 6 i ( 248) 374 91.2 2.4e-18 NP_001308767 (OMIM: 114815,613227) carbonic anhydr ( 263) 368 89.8 6.3e-18 NP_001076003 (OMIM: 604642) carbonic anhydrase-rel ( 328) 346 85.1 2.2e-16 NP_064563 (OMIM: 604642) carbonic anhydrase-relate ( 328) 346 85.1 2.2e-16 >>NP_000708 (OMIM: 114760,600852) carbonic anhydrase 4 p (312 aa) initn: 2102 init1: 2102 opt: 2102 Z-score: 2508.3 bits: 472.3 E(85289): 5.7e-133 Smith-Waterman score: 2102; 100.0% identity (100.0% similar) in 312 aa overlap (1-312:1-312) 10 20 30 40 50 60 pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG 250 260 270 280 290 300 310 pF1KE4 PMLACLLAGFLR :::::::::::: NP_000 PMLACLLAGFLR 310 >>XP_016880501 (OMIM: 114760,600852) PREDICTED: carbonic (222 aa) initn: 1483 init1: 1483 opt: 1483 Z-score: 1772.7 bits: 335.7 E(85289): 5.3e-92 Smith-Waterman score: 1483; 100.0% identity (100.0% similar) in 222 aa overlap (91-312:1-222) 70 80 90 100 110 120 pF1KE4 AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD :::::::::::::::::::::::::::::: XP_016 MMLLENKASISGGGLPAPYQAKQLHLHWSD 10 20 30 130 140 150 160 170 180 pF1KE4 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE4 QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE4 PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG 160 170 180 190 200 210 310 pF1KE4 PMLACLLAGFLR :::::::::::: XP_016 PMLACLLAGFLR 220 >>XP_005257696 (OMIM: 114760,600852) PREDICTED: carbonic (336 aa) initn: 1169 init1: 1169 opt: 1169 Z-score: 1395.9 bits: 266.5 E(85289): 5.2e-71 Smith-Waterman score: 2044; 92.9% identity (92.9% similar) in 336 aa overlap (1-312:1-336) 10 20 30 40 50 60 pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVE--------- ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEIGRMNWPPP 130 140 150 160 170 180 180 190 200 210 pF1KE4 ---------------AGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRH ::::::::::::::::::::::::::::::::::::::::::::: XP_005 LAPCRLSQDPSLPFQAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRH 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE4 YFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQL 250 260 270 280 290 300 280 290 300 310 pF1KE4 GQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR :::::::::::::::::::::::::::::::::::: XP_005 GQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 310 320 330 >>XP_011523485 (OMIM: 114760,600852) PREDICTED: carbonic (246 aa) initn: 942 init1: 942 opt: 945 Z-score: 1130.9 bits: 217.1 E(85289): 3e-56 Smith-Waterman score: 1425; 90.2% identity (90.2% similar) in 246 aa overlap (91-312:1-246) 70 80 90 100 110 120 pF1KE4 AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD :::::::::::::::::::::::::::::: XP_011 MMLLENKASISGGGLPAPYQAKQLHLHWSD 10 20 30 130 140 150 160 170 pF1KE4 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVE--------- ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEIGRMNWPPP 40 50 60 70 80 90 180 190 200 210 pF1KE4 ---------------AGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRH ::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAPCRLSQDPSLPFQAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRH 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE4 YFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQL 160 170 180 190 200 210 280 290 300 310 pF1KE4 GQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR :::::::::::::::::::::::::::::::::::: XP_011 GQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 220 230 240 >>NP_996808 (OMIM: 143860,603263) carbonic anhydrase 12 (343 aa) initn: 287 init1: 191 opt: 518 Z-score: 619.9 bits: 123.0 E(85289): 8.6e-28 Smith-Waterman score: 518; 32.6% identity (60.1% similar) in 316 aa overlap (3-311:12-315) 10 20 30 40 50 pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQ .::..: . . :. :.: : ... : .: : NP_996 MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYP-----SCGGLLQ 10 20 30 40 50 60 70 80 90 100 pF1KE4 SPINIVTTKAKVDKKLGRFFFSGYD--KKQTWTVQNNGHSVMMLLENKASISGGGLPAPY :::.. . . : .: . :.::. .. . . :::::: . : . :.: : . : NP_996 SPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQG--LQSRY 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 QAKQLHLHWSDLPY--KGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLA .: ::::::.. : .::::...:.::: :.:::: . . ... :.. . .:::: NP_996 SATQLHLHWGN-PNDPHGSEHTVSGQHFAAELHIVHYN-SDLYPDASTASNKSEGLAVLA 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 FLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTP :.: :. : ... . :... . . . .. .::: :. .:.:: :::::: NP_996 VLIEMGS-FNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLP--ERTAEYYRYRGSLTTP 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 TCDEKVVWTVFREPIQLHREQILAFSQKLY---YDKEQTVSMKDNVRPLQQLGQRTVIKS :. :.:::::.:.:. .::.::. :: .: . : .: : .:.. .: : : NP_996 PCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTS 230 240 250 260 270 280 290 300 310 pF1KE4 GAPGRPLPWALPALLGPMLACLLAGFLR . : : :: ..:: .. ... .: NP_996 FSQGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA 290 300 310 320 330 340 >>NP_001209 (OMIM: 143860,603263) carbonic anhydrase 12 (354 aa) initn: 394 init1: 191 opt: 502 Z-score: 600.7 bits: 119.5 E(85289): 1e-26 Smith-Waterman score: 502; 32.9% identity (59.5% similar) in 316 aa overlap (3-311:12-314) 10 20 30 40 50 pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQ .::..: . . :. :.: : ... : .: : NP_001 MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYP-----SCGGLLQ 10 20 30 40 50 60 70 80 90 100 pF1KE4 SPINIVTTKAKVDKKLGRFFFSGYD--KKQTWTVQNNGHSVMMLLENKASISGGGLPAPY :::.. . . : .: . :.::. .. . . :::::: . : . :.: : . : NP_001 SPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQG--LQSRY 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 QAKQLHLHWSDLPY--KGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLA .: ::::::.. : .::::...:.::: :.:::: . . ... :.. . .:::: NP_001 SATQLHLHWGN-PNDPHGSEHTVSGQHFAAELHIVHYN-SDLYPDASTASNKSEGLAVLA 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 FLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTP :.: :. : ... . :... . . . .. .::: :. .:.:: :::::: NP_001 VLIEMGS-FNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLP--ERTAEYYRYRGSLTTP 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 TCDEKVVWTVFREPIQLHREQILAFSQKLY---YDKEQTVSMKDNVRPLQQLGQRTVIKS :. :.:::::.:.:. .::.::. :: .: . : .: : .:.. .: : : NP_001 PCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTS 230 240 250 260 270 280 290 300 310 pF1KE4 GAPGRPLPWALPALLGPMLACLLAGFLR . . . : :: .:. :::.: NP_001 FSQVQ-VCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATK 290 300 310 320 330 340 >>XP_005245116 (OMIM: 604832) PREDICTED: carbonic anhydr (336 aa) initn: 475 init1: 202 opt: 497 Z-score: 595.0 bits: 118.4 E(85289): 2.1e-26 Smith-Waterman score: 497; 33.7% identity (61.3% similar) in 297 aa overlap (16-306:15-301) 10 20 30 40 50 60 pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK .:.. .:: :: ....: : .: .. ::::.: : . XP_005 MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYP-----ECGNNAQSPIDIQTDS 10 20 30 40 50 70 80 90 100 110 pF1KE4 AKVDKKLGRFFFSGYDKKQT--WTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHW . : : . :::. : ..::::.:.. : . .. :::: : : :::::: XP_005 VTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPS--TLYLGGLPRKYVAAQLHLHW 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 SDLPYKG-SEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVN .. : :::....: :.:::: .. . ...:: . . .:::..:.:.: : XP_005 GQKGSPGGSEHQINSEATFAELHIVHY-DSDSYDSLSEAAERPQGLAVLGILIEVGETKN 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 EGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTV ... .. : .. . ...:.. .: .::::. : .:::: :::::: : ..:.::: XP_005 IAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQ--LGQYFRYNGSLTTPPCYQSVLWTV 180 190 200 210 220 240 250 260 270 280 290 pF1KE4 FREPIQLHREQILAFSQKLYYDKEQTVSMK-DNVRPLQQLGQRTVIKSGAPGRPLPWA-- : . :. ::. .. :. .:. .. .: : :: :.:: :. : : . XP_005 FYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQGSSYTTGEM 230 240 250 260 270 280 300 310 pF1KE4 LPALLGPMLACLLAGFLR : .: ...:: XP_005 LSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA 290 300 310 320 330 >>NP_036245 (OMIM: 604832) carbonic anhydrase 14 precurs (337 aa) initn: 355 init1: 213 opt: 495 Z-score: 592.6 bits: 117.9 E(85289): 2.8e-26 Smith-Waterman score: 495; 34.0% identity (61.7% similar) in 303 aa overlap (16-307:15-305) 10 20 30 40 50 60 pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK .:.. .:: :: ....: : .: .. ::::.: : . NP_036 MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYP-----ECGNNAQSPIDIQTDS 10 20 30 40 50 70 80 90 100 110 pF1KE4 AKVDKKLGRFFFSGYDKKQT--WTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHW . : : . :::. : ..::::.:.. : ... :::: : : :::::: NP_036 VTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLP--STLYLGGLPRKYVAAQLHLHW 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 SDLPYKG-SEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVN .. : :::....: :.:::: .. . ...:: . . .:::..:.:.: : NP_036 GQKGSPGGSEHQINSEATFAELHIVHY-DSDSYDSLSEAAERPQGLAVLGILIEVGETKN 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 EGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTV ... .. : .. . ...:.. .: .:::: .: .:::: :::::: : ..:.::: NP_036 IAYEHILSHLHEVRHKDQKTSVPPFNLRELLPK--QLGQYFRYNGSLTTPPCYQSVLWTV 180 190 200 210 220 240 250 260 270 280 pF1KE4 FREPIQLHREQILAFSQKLYYDKEQTVSMK-DNVRPLQQLGQRTV----IKSGAP---GR : . :. ::. .. :. .:. .. .: : :: :.:: : :..:. :. NP_036 FYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGE 230 240 250 260 270 280 290 300 310 pF1KE4 PLPWALPALLGPMLACLLAGFLR : .. :.: . ::: NP_036 MLSLGVGILVGCL--CLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA 290 300 310 320 330 >>XP_006711322 (OMIM: 604832) PREDICTED: carbonic anhydr (318 aa) initn: 437 init1: 202 opt: 492 Z-score: 589.4 bits: 117.2 E(85289): 4.3e-26 Smith-Waterman score: 492; 34.7% identity (62.5% similar) in 277 aa overlap (16-288:15-281) 10 20 30 40 50 60 pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK .:.. .:: :: ....: : .: .. ::::.: : . XP_006 MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYP-----ECGNNAQSPIDIQTDS 10 20 30 40 50 70 80 90 100 110 pF1KE4 AKVDKKLGRFFFSGYDKKQT--WTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHW . : : . :::. : ..::::.:.. : ... :::: : : :::::: XP_006 VTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLP--STLYLGGLPRKYVAAQLHLHW 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 SDLPYKG-SEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVN .. : :::....: :.:::: .. . ...:: . . .:::..:.:.: : XP_006 GQKGSPGGSEHQINSEATFAELHIVHY-DSDSYDSLSEAAERPQGLAVLGILIEVGETKN 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 EGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTV ... .. : .. . ...:.. .: .:::: .: .:::: :::::: : ..:.::: XP_006 IAYEHILSHLHEVRHKDQKTSVPPFNLRELLPK--QLGQYFRYNGSLTTPPCYQSVLWTV 180 190 200 210 220 240 250 260 270 280 290 pF1KE4 FREPIQLHREQILAFSQKLYYDKEQTVSMK-DNVRPLQQLGQRTVIKSGAPGRPLPWALP : . :. ::. .. :. .:. .. .: : :: :.:: :. : : XP_006 FYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQGSSYTTGRR 230 240 250 260 270 280 300 310 pF1KE4 ALLGPMLACLLAGFLR XP_006 GWKTERVWSSPQHKPRLRHKFLLRYHGCG 290 300 310 >>XP_011540385 (OMIM: 114780) PREDICTED: carbonic anhydr (294 aa) initn: 282 init1: 126 opt: 490 Z-score: 587.5 bits: 116.8 E(85289): 5.5e-26 Smith-Waterman score: 490; 33.1% identity (62.8% similar) in 296 aa overlap (1-289:5-285) 10 20 30 40 50 pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQA-ESSNYPCLVPVKWGGNCQKDRQSPIN :: :. ::.: .:. : : : : . ...: :. : .:::::: XP_011 MCSTMRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPA-----CGGQRQSPIN 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 IVTTKAKVDKKLGRFFFSGYDKKQ-TWTVQNNGHSVMMLLEN--KASISGGGLPAPYQAK . ::.. . .: . ..::. . . . ::::.:.. : . . ... : . : :. XP_011 LQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTV---YIAQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 QLHLHW--SDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLV :.:.:: .. .::::..:: . ..:.:::: . : : .. ::: : .:::: .: XP_011 QMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNSKYKSYDI--AQDAPDGLAVLAAFV 120 130 140 150 160 170 180 190 200 210 220 pF1KE4 EAGTQV-NEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTC :. . : .. .. :.:: : . ::.. .. :.::.. :.::. : :::::: : XP_011 EVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRN--LQHYYTYHGSLTTPPC 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 DEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGR :.: : :. . ..: : :. . ..: ...:. ... : : :..: :..:. :.. XP_011 TENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTI--HNDYRRTQPLNHR-VVESNFPNQ 230 240 250 260 270 280 290 300 310 pF1KE4 PLPWALPALLGPMLACLLAGFLR XP_011 ENCIPAGLI 290 312 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 23:27:34 2016 done: Sat Nov 5 23:27:35 2016 Total Scan time: 6.800 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]