FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8502, 864 aa 1>>>pF1KB8502 864 - 864 aa - 864 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.2037+/-0.000429; mu= 12.3553+/- 0.027 mean_var=554.0349+/-128.313, 0's: 0 Z-trim(122.2): 746 B-trim: 2210 in 1/58 Lambda= 0.054489 statistics sampled from 39194 (40064) to 39194 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.765), E-opt: 0.2 (0.47), width: 16 Scan time: 13.080 The best scores are: opt bits E(85289) NP_002335 (OMIM: 151520) leukocyte tyrosine kinase ( 864) 6041 491.0 1e-137 NP_996844 (OMIM: 151520) leukocyte tyrosine kinase ( 803) 3779 313.1 3.3e-84 XP_011519858 (OMIM: 151520) PREDICTED: leukocyte t ( 880) 3138 262.8 5e-69 XP_016877672 (OMIM: 151520) PREDICTED: leukocyte t ( 800) 3114 260.8 1.8e-68 XP_016877671 (OMIM: 151520) PREDICTED: leukocyte t ( 837) 2940 247.2 2.4e-64 XP_016877670 (OMIM: 151520) PREDICTED: leukocyte t ( 885) 2938 247.1 2.7e-64 XP_011519859 (OMIM: 151520) PREDICTED: leukocyte t ( 824) 2928 246.2 4.6e-64 NP_004295 (OMIM: 105590,613014) ALK tyrosine kinas (1620) 2626 223.0 8.7e-57 NP_001129157 (OMIM: 151520) leukocyte tyrosine kin ( 734) 2276 194.9 1.2e-48 XP_011534355 (OMIM: 165020) PREDICTED: proto-oncog (2299) 974 93.4 1.3e-17 XP_016866662 (OMIM: 165020) PREDICTED: proto-oncog (2333) 974 93.5 1.3e-17 XP_016866661 (OMIM: 165020) PREDICTED: proto-oncog (2334) 974 93.5 1.3e-17 XP_006715611 (OMIM: 165020) PREDICTED: proto-oncog (2342) 974 93.5 1.3e-17 XP_011534354 (OMIM: 165020) PREDICTED: proto-oncog (2343) 974 93.5 1.3e-17 NP_002935 (OMIM: 165020) proto-oncogene tyrosine-p (2347) 974 93.5 1.3e-17 XP_011534353 (OMIM: 165020) PREDICTED: proto-oncog (2348) 974 93.5 1.3e-17 XP_011534352 (OMIM: 165020) PREDICTED: proto-oncog (2356) 974 93.5 1.3e-17 XP_011534351 (OMIM: 165020) PREDICTED: proto-oncog (2357) 974 93.5 1.3e-17 NP_055030 (OMIM: 147671) insulin receptor-related (1297) 931 89.6 1e-16 XP_011519819 (OMIM: 147370,270450) PREDICTED: insu ( 922) 889 86.0 8.6e-16 XP_011519818 (OMIM: 147370,270450) PREDICTED: insu (1064) 889 86.2 9.1e-16 XP_016877628 (OMIM: 147370,270450) PREDICTED: insu (1246) 889 86.3 9.8e-16 NP_001278787 (OMIM: 147370,270450) insulin-like gr (1366) 889 86.4 1e-15 NP_000866 (OMIM: 147370,270450) insulin-like growt (1367) 889 86.4 1e-15 XP_016877627 (OMIM: 147370,270450) PREDICTED: insu (1391) 889 86.4 1e-15 XP_016877626 (OMIM: 147370,270450) PREDICTED: insu (1392) 889 86.4 1e-15 XP_016877625 (OMIM: 147370,270450) PREDICTED: insu (1392) 889 86.4 1e-15 XP_011526291 (OMIM: 147670,246200,262190,609968,61 (1369) 885 86.0 1.3e-15 NP_001073285 (OMIM: 147670,246200,262190,609968,61 (1370) 885 86.0 1.3e-15 XP_011526290 (OMIM: 147670,246200,262190,609968,61 (1381) 885 86.0 1.3e-15 NP_000199 (OMIM: 147670,246200,262190,609968,61054 (1382) 885 86.0 1.3e-15 XP_011534356 (OMIM: 165020) PREDICTED: proto-oncog (2200) 859 84.4 6.5e-15 NP_001007793 (OMIM: 155240,191315,256800) high aff ( 760) 781 77.4 2.8e-13 NP_001012331 (OMIM: 155240,191315,256800) high aff ( 790) 781 77.4 2.9e-13 NP_002520 (OMIM: 155240,191315,256800) high affini ( 796) 781 77.4 2.9e-13 XP_016870243 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 761 75.9 8.7e-13 XP_011517020 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 761 75.9 8.7e-13 XP_016870241 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 761 75.9 8.7e-13 NP_001018074 (OMIM: 600456,613886) BDNF/NT-3 growt ( 822) 761 75.9 8.7e-13 XP_016870242 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 761 75.9 8.7e-13 XP_005252060 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 761 75.9 8.8e-13 XP_016870240 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 761 75.9 8.8e-13 XP_005252061 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 761 75.9 8.8e-13 NP_006171 (OMIM: 600456,613886) BDNF/NT-3 growth f ( 838) 761 75.9 8.8e-13 XP_005252058 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 761 75.9 8.8e-13 NP_001265528 (OMIM: 109135) tyrosine-protein kinas ( 626) 757 75.4 9.6e-13 NP_001690 (OMIM: 109135) tyrosine-protein kinase r ( 885) 757 75.6 1.1e-12 NP_068713 (OMIM: 109135) tyrosine-protein kinase r ( 894) 757 75.6 1.1e-12 XP_016877741 (OMIM: 191316) PREDICTED: NT-3 growth ( 448) 718 72.0 6.9e-12 XP_016877740 (OMIM: 191316) PREDICTED: NT-3 growth ( 456) 718 72.0 7e-12 >>NP_002335 (OMIM: 151520) leukocyte tyrosine kinase rec (864 aa) initn: 6041 init1: 6041 opt: 6041 Z-score: 2593.6 bits: 491.0 E(85289): 1e-137 Smith-Waterman score: 6041; 100.0% identity (100.0% similar) in 864 aa overlap (1-864:1-864) 10 20 30 40 50 60 pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL 790 800 810 820 830 840 850 860 pF1KB8 SSGLKPLKSRGLQPQNLWNPTYRS :::::::::::::::::::::::: NP_002 SSGLKPLKSRGLQPQNLWNPTYRS 850 860 >>NP_996844 (OMIM: 151520) leukocyte tyrosine kinase rec (803 aa) initn: 3749 init1: 3749 opt: 3779 Z-score: 1632.8 bits: 313.1 E(85289): 3.3e-84 Smith-Waterman score: 5455; 92.9% identity (92.9% similar) in 864 aa overlap (1-864:1-803) 10 20 30 40 50 60 pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC ::::::::::::::::::::::::::::::::: NP_996 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGG--------------------------- 250 260 270 310 320 330 340 350 360 pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF :::::::::::::::::::::::::: NP_996 ----------------------------------DASETDNLWADGEDGVSFIHPSSELF 280 290 370 380 390 400 410 420 pF1KB8 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK 300 310 320 330 340 350 430 440 450 460 470 480 pF1KB8 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA 360 370 380 390 400 410 490 500 510 520 530 540 pF1KB8 PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ 420 430 440 450 460 470 550 560 570 580 590 600 pF1KB8 VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS 480 490 500 510 520 530 610 620 630 640 650 660 pF1KB8 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA 540 550 560 570 580 590 670 680 690 700 710 720 pF1KB8 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG 600 610 620 630 640 650 730 740 750 760 770 780 pF1KB8 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC 660 670 680 690 700 710 790 800 810 820 830 840 pF1KB8 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL 720 730 740 750 760 770 850 860 pF1KB8 SSGLKPLKSRGLQPQNLWNPTYRS :::::::::::::::::::::::: NP_996 SSGLKPLKSRGLQPQNLWNPTYRS 780 790 800 >>XP_011519858 (OMIM: 151520) PREDICTED: leukocyte tyros (880 aa) initn: 3131 init1: 3131 opt: 3138 Z-score: 1360.2 bits: 262.8 E(85289): 5e-69 Smith-Waterman score: 5995; 98.1% identity (98.2% similar) in 880 aa overlap (1-864:1-880) 10 20 30 40 50 60 pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK 370 380 390 400 410 420 430 440 450 460 pF1KB8 PPGPLVLMVAVVATSTLSLLMVCGVLIL----------------VKQKKWQGLQEMRLPS :::::::::::::::::::::::::::: .::::::::::::::: XP_011 PPGPLVLMVAVVATSTLSLLMVCGVLILGTKRLAGTVDSRLLLSMKQKKWQGLQEMRLPS 430 440 450 460 470 480 470 480 490 500 510 520 pF1KB8 PELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEV 490 500 510 520 530 540 530 540 550 560 570 580 pF1KB8 YEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRAT 550 560 570 580 590 600 590 600 610 620 630 640 pF1KB8 PRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDI 610 620 630 640 650 660 650 660 670 680 690 700 pF1KB8 AARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKT 670 680 690 700 710 720 710 720 730 740 750 760 pF1KB8 DSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEP 730 740 750 760 770 780 770 780 790 800 810 820 pF1KB8 ELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELS 790 800 810 820 830 840 830 840 850 860 pF1KB8 PEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS :::::::::::::::::::::::::::::::::::::::: XP_011 PEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS 850 860 870 880 >>XP_016877672 (OMIM: 151520) PREDICTED: leukocyte tyros (800 aa) initn: 4803 init1: 2555 opt: 3114 Z-score: 1350.3 bits: 260.8 E(85289): 1.8e-68 Smith-Waterman score: 5262; 89.6% identity (90.6% similar) in 869 aa overlap (1-864:1-800) 10 20 30 40 50 60 pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF 310 320 330 340 350 360 370 380 390 400 410 pF1KB8 LQPLAV-----TENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC :::::: ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQPLAVLLLTVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB8 MDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTS ::::::::::::::::::::::::::::::::: : :.: : .: XP_016 MDLHKPPGPLVLMVAVVATSTLSLLMVCGVLIL--GGAW--------PGPVL------AS 430 440 450 460 480 490 500 510 520 530 pF1KB8 AIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGD : : :. :. :.: . XP_016 ATR-------CHRGF-PSQCY--------------------------------------- 470 540 550 560 570 580 590 pF1KB8 SSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSG . .::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ------SAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSG 480 490 500 510 520 530 600 610 620 630 640 650 pF1KB8 GDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAG 540 550 560 570 580 590 660 670 680 690 700 710 pF1KB8 PSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWE 600 610 620 630 640 650 720 730 740 750 760 770 pF1KB8 IFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILE 660 670 680 690 700 710 780 790 800 810 820 830 pF1KB8 RLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSP 720 730 740 750 760 770 840 850 860 pF1KB8 LGPWLSSGLKPLKSRGLQPQNLWNPTYRS ::::::::::::::::::::::::::::: XP_016 LGPWLSSGLKPLKSRGLQPQNLWNPTYRS 780 790 800 >>XP_016877671 (OMIM: 151520) PREDICTED: leukocyte tyros (837 aa) initn: 5461 init1: 2920 opt: 2940 Z-score: 1276.2 bits: 247.2 E(85289): 2.4e-64 Smith-Waterman score: 5745; 95.7% identity (95.7% similar) in 869 aa overlap (1-864:1-837) 10 20 30 40 50 60 pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF 310 320 330 340 350 360 370 380 390 400 410 pF1KB8 LQPLAV-----TENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC :::::: ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQPLAVLLLTVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB8 MDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTS : ::::::::::::::::::::::::::: XP_016 M--------------------------------VKQKKWQGLQEMRLPSPELELSKLRTS 430 440 480 490 500 510 520 530 pF1KB8 AIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGD 450 460 470 480 490 500 540 550 560 570 580 590 pF1KB8 SSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSG 510 520 530 540 550 560 600 610 620 630 640 650 pF1KB8 GDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAG 570 580 590 600 610 620 660 670 680 690 700 710 pF1KB8 PSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWE 630 640 650 660 670 680 720 730 740 750 760 770 pF1KB8 IFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILE 690 700 710 720 730 740 780 790 800 810 820 830 pF1KB8 RLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSP 750 760 770 780 790 800 840 850 860 pF1KB8 LGPWLSSGLKPLKSRGLQPQNLWNPTYRS ::::::::::::::::::::::::::::: XP_016 LGPWLSSGLKPLKSRGLQPQNLWNPTYRS 810 820 830 >>XP_016877670 (OMIM: 151520) PREDICTED: leukocyte tyros (885 aa) initn: 5452 init1: 2911 opt: 2938 Z-score: 1275.2 bits: 247.1 E(85289): 2.7e-64 Smith-Waterman score: 5975; 97.5% identity (97.6% similar) in 885 aa overlap (1-864:1-885) 10 20 30 40 50 60 pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF 310 320 330 340 350 360 370 380 390 400 410 pF1KB8 LQPLAV-----TENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC :::::: ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQPLAVLLLTVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC 370 380 390 400 410 420 420 430 440 450 pF1KB8 MDLHKPPGPLVLMVAVVATSTLSLLMVCGVLIL----------------VKQKKWQGLQE ::::::::::::::::::::::::::::::::: .:::::::::: XP_016 MDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILGTKRLAGTVDSRLLLSMKQKKWQGLQE 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB8 MRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHG 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB8 AFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGL 550 560 570 580 590 600 580 590 600 610 620 630 pF1KB8 SLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHF 610 620 630 640 650 660 640 650 660 670 680 690 pF1KB8 IHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGI 670 680 690 700 710 720 700 710 720 730 740 750 pF1KB8 FTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQC 730 740 750 760 770 780 760 770 780 790 800 810 pF1KB8 WQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQ 790 800 810 820 830 840 820 830 840 850 860 pF1KB8 PQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS ::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS 850 860 870 880 >>XP_011519859 (OMIM: 151520) PREDICTED: leukocyte tyros (824 aa) initn: 4783 init1: 2911 opt: 2928 Z-score: 1271.2 bits: 246.2 E(85289): 4.6e-64 Smith-Waterman score: 5389; 90.6% identity (90.7% similar) in 885 aa overlap (1-864:1-824) 10 20 30 40 50 60 pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC ::::::::::::::::::::::::::::::::: XP_011 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGG--------------------------- 250 260 270 310 320 330 340 350 360 pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF :::::::::::::::::::::::::: XP_011 ----------------------------------DASETDNLWADGEDGVSFIHPSSELF 280 290 370 380 390 400 410 pF1KB8 LQPLAV-----TENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC :::::: ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQPLAVLLLTVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTC 300 310 320 330 340 350 420 430 440 450 pF1KB8 MDLHKPPGPLVLMVAVVATSTLSLLMVCGVLIL----------------VKQKKWQGLQE ::::::::::::::::::::::::::::::::: .:::::::::: XP_011 MDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILGTKRLAGTVDSRLLLSMKQKKWQGLQE 360 370 380 390 400 410 460 470 480 490 500 510 pF1KB8 MRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHG 420 430 440 450 460 470 520 530 540 550 560 570 pF1KB8 AFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGL 480 490 500 510 520 530 580 590 600 610 620 630 pF1KB8 SLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHF 540 550 560 570 580 590 640 650 660 670 680 690 pF1KB8 IHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGI 600 610 620 630 640 650 700 710 720 730 740 750 pF1KB8 FTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQC 660 670 680 690 700 710 760 770 780 790 800 810 pF1KB8 WQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQ 720 730 740 750 760 770 820 830 840 850 860 pF1KB8 PQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS ::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS 780 790 800 810 820 >>NP_004295 (OMIM: 105590,613014) ALK tyrosine kinase re (1620 aa) initn: 2767 init1: 2275 opt: 2626 Z-score: 1140.5 bits: 223.0 E(85289): 8.7e-57 Smith-Waterman score: 3136; 55.6% identity (75.9% similar) in 859 aa overlap (4-843:608-1450) 10 20 30 pF1KB8 MGCWGQLLVWFGAAGAILCSSPG---SQETFLR : :...:.: .. . . . : . .: NP_004 GRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLT 580 590 600 610 620 630 40 50 60 70 80 pF1KB8 SSP----LPLASPSPRDPKVSAPPSILEPA--SPLNSPGTEGS--WLFSTCGASGRHGPT : : ..:. :. : . :.:. :: ..: . . :::.:::::: :::: NP_004 ISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPT 640 650 660 670 680 690 90 100 110 120 130 140 pF1KB8 QTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGV :.::..:: .... : ::. : :.:.:.:.::. : ::.::::::::.:: . :.::: NP_004 QAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGV 700 710 720 730 740 750 150 160 170 180 190 200 pF1KB8 FVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCLGESRAVEEHAAMDGSEGVPGSR : .::.: . ::::::::::::::. . : ::.::. ..::. .. : . NP_004 SVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRS-----VH 760 770 780 790 800 810 210 220 230 240 250 260 pF1KB8 RWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAP .:::::::::::::::... : ::..::::::::: : . ::.::: : . NP_004 EWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFH----PERLENNSSVL 820 830 840 850 860 270 280 290 300 310 320 pF1KB8 GSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGCSEAWATLGWAAAGGFGGGGGAC : .: .:::::::::.. . ::.:::::: ::..: .: :: . ::::::::.: NP_004 GLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGC 870 880 890 900 910 920 330 340 350 360 370 380 pF1KB8 TAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCS ..::::::: ::.:. ... ::::::::: : . :. : : :.::::.:...:::: NP_004 SSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCS 930 940 950 960 970 980 390 400 410 420 430 440 pF1KB8 HCPLRDCQWQAELQLAECLCPEGMELAVDNVTCM--DLHKPPGPLVLMVAVVATSTLSLL :: . .:. . : . . :.: .: :: :.:.:. .: :: :...::... .. : NP_004 HCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAAL 990 1000 1010 1020 1030 1040 450 460 470 480 490 pF1KB8 MVC--GVLILVKQKKWQGLQ--EMRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSW .. :..: : ..: : :: .:.: ::: .:::::::.: : :: :: .: . : NP_004 VLAFSGIMI-VYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSIS- 1050 1060 1070 1080 1090 1100 500 510 520 530 540 550 pF1KB8 PLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDEL . :: :.::.:.:::::::::::: : :.:.: ::::::.:::::.:: :::: NP_004 ----DLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDEL 1110 1120 1130 1140 1150 1160 560 570 580 590 600 610 pF1KB8 DFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLV :::::::::::: :::::::.:.::.. ::.::::::.:::.:::::..::. .::: :. NP_004 DFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLA 1170 1180 1190 1200 1210 1220 620 630 640 650 660 670 pF1KB8 MRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASY : :::..:.::: ::.:::::::::::::::::::.: ::.::::::::::::::::::: NP_004 MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASY 1230 1240 1250 1260 1270 1280 680 690 700 710 720 730 pF1KB8 YRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFV ::.: :.:::::::::::.:::::::::.:::::::::::::::::::...:::::.:: NP_004 YRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV 1290 1300 1310 1320 1330 1340 740 750 760 770 780 790 pF1KB8 VGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELG ..:::::::..:::::::::::::::.:: ::.:: ::::..::::::::.:. ::.: : NP_004 TSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYG 1350 1360 1370 1380 1390 1400 800 810 820 830 840 850 pF1KB8 PTPEEEGTSGLGNRSLECLRPPQ--PQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQP : ::: . .. : . :: :. . :. .: .. : : ::: NP_004 PLVEEEEKVPVRPKDPEGV-PPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEI 1410 1420 1430 1440 1450 1460 860 pF1KB8 QNLWNPTYRS NP_004 SVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNP 1470 1480 1490 1500 1510 1520 >>NP_001129157 (OMIM: 151520) leukocyte tyrosine kinase (734 aa) initn: 4134 init1: 2262 opt: 2276 Z-score: 994.6 bits: 194.9 E(85289): 1.2e-48 Smith-Waterman score: 4696; 83.1% identity (84.0% similar) in 864 aa overlap (1-864:1-734) 10 20 30 40 50 60 pF1KB8 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC ::::::::::::::::::::::::::::::::: NP_001 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGG--------------------------- 250 260 270 310 320 330 340 350 360 pF1KB8 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF :::::::::::::::::::::::::: NP_001 ----------------------------------DASETDNLWADGEDGVSFIHPSSELF 280 290 370 380 390 400 410 420 pF1KB8 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK 300 310 320 330 340 350 430 440 450 460 470 480 pF1KB8 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA :::::::::::::::::::::::::::: : :.: : .:: : NP_001 PPGPLVLMVAVVATSTLSLLMVCGVLIL--GGAW--------PGPVL------ASATR-- 360 370 380 390 400 490 500 510 520 530 540 pF1KB8 PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ :. :. :.: . NP_001 -----CHRGF-PSQCY-------------------------------------------- 410 550 560 570 580 590 600 pF1KB8 VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS . .:::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -SAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS 420 430 440 450 460 470 610 620 630 640 650 660 pF1KB8 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA 480 490 500 510 520 530 670 680 690 700 710 720 pF1KB8 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG 540 550 560 570 580 590 730 740 750 760 770 780 pF1KB8 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC 600 610 620 630 640 650 790 800 810 820 830 840 pF1KB8 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL 660 670 680 690 700 710 850 860 pF1KB8 SSGLKPLKSRGLQPQNLWNPTYRS :::::::::::::::::::::::: NP_001 SSGLKPLKSRGLQPQNLWNPTYRS 720 730 >>XP_011534355 (OMIM: 165020) PREDICTED: proto-oncogene (2299 aa) initn: 931 init1: 553 opt: 974 Z-score: 437.5 bits: 93.4 E(85289): 1.3e-17 Smith-Waterman score: 974; 46.9% identity (74.6% similar) in 307 aa overlap (510-813:1897-2196) 480 490 500 510 520 530 pF1KB8 APNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPG-DSSP .:: :: ::::::::: .. . : :. XP_011 GVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE 1870 1880 1890 1900 1910 1920 540 550 560 570 580 590 pF1KB8 LQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDM ..::.::: . . :....:: :: ..::: : ::.. .:. : :. :.:::: :::. XP_011 IKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDL 1930 1940 1950 1960 1970 1980 600 610 620 630 640 650 pF1KB8 KSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPS- ..::..: :.. ::..: ::..:: :::. ::::::.::::::.: . XP_011 LTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTS 1990 2000 2010 2020 2030 2040 660 670 680 690 700 710 pF1KB8 -RVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEI :..::::::.:::::. .:::. ..::::.:: ::....::::...: ::::.:.::: XP_011 PRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEI 2050 2060 2070 2080 2090 2100 720 730 740 750 760 770 pF1KB8 FSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILER ..::..:::...: .::..: :::..:::.:: .. .::::: .::. ::.: : .. XP_011 LTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQ 2110 2120 2130 2140 2150 2160 780 790 800 810 820 830 pF1KB8 LQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPL :: . :::. . .: ..::. :.:.: XP_011 LQLFRN--FFLNSIYK-----SRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETK 2170 2180 2190 2200 2210 840 850 860 pF1KB8 GPWLSSGLKPLKSRGLQPQNLWNPTYRS XP_011 NREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSG 2220 2230 2240 2250 2260 2270 864 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 02:18:27 2016 done: Tue Nov 8 02:18:29 2016 Total Scan time: 13.080 Total Display time: 0.240 Function used was FASTA [36.3.4 Apr, 2011]