FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1874, 396 aa 1>>>pF1KE1874 396 - 396 aa - 396 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2221+/-0.00031; mu= 17.8779+/- 0.019 mean_var=67.8834+/-13.975, 0's: 0 Z-trim(116.8): 11 B-trim: 1069 in 1/55 Lambda= 0.155666 statistics sampled from 28332 (28342) to 28332 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.697), E-opt: 0.2 (0.332), width: 16 Scan time: 8.680 The best scores are: opt bits E(85289) NP_066382 (OMIM: 233420,605423,607080) desert hedg ( 396) 2703 615.7 6.1e-176 XP_016874869 (OMIM: 233420,605423,607080) PREDICTE ( 349) 2022 462.7 6e-130 XP_016874870 (OMIM: 233420,605423,607080) PREDICTE ( 282) 1934 442.9 4.5e-124 NP_002172 (OMIM: 112500,600726,607778) indian hedg ( 411) 1520 350.0 6e-96 NP_000184 (OMIM: 142945,147250,269160,600725,61163 ( 462) 1206 279.5 1.1e-74 XP_011514782 (OMIM: 142945,147250,269160,600725,61 ( 375) 812 191.0 4.1e-48 XP_011514781 (OMIM: 142945,147250,269160,600725,61 ( 375) 812 191.0 4.1e-48 NP_001297391 (OMIM: 142945,147250,269160,600725,61 ( 179) 526 126.6 4.8e-29 >>NP_066382 (OMIM: 233420,605423,607080) desert hedgehog (396 aa) initn: 2703 init1: 2703 opt: 2703 Z-score: 3279.7 bits: 615.7 E(85289): 6.1e-176 Smith-Waterman score: 2703; 100.0% identity (100.0% similar) in 396 aa overlap (1-396:1-396) 10 20 30 40 50 60 pF1KE1 MALLTNLLPLCCLALLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 MALLTNLLPLCCLALLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 GPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 VRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 VRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 HVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 HVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 LFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 LFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 LAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 LAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPL 310 320 330 340 350 360 370 380 390 pF1KE1 RLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELLG :::::::::::::::::::::::::::::::::::: NP_066 RLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELLG 370 380 390 >>XP_016874869 (OMIM: 233420,605423,607080) PREDICTED: d (349 aa) initn: 2019 init1: 2019 opt: 2022 Z-score: 2453.9 bits: 462.7 E(85289): 6e-130 Smith-Waterman score: 2022; 98.7% identity (99.7% similar) in 301 aa overlap (96-396:50-349) 70 80 90 100 110 120 pF1KE1 RVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRV :: ...:::::::::::::::::::::::: XP_016 SLPQVQASSRSFFSSSPLSPCRGLPRSAQGDR-YSQRCKERVNALAIAVMNMWPGVRLRV 20 30 40 50 60 70 130 140 150 160 170 180 pF1KE1 TEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVS 80 90 100 110 120 130 190 200 210 220 230 240 pF1KE1 VKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDR 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE1 DLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGG 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE1 DALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHA 260 270 280 290 300 310 370 380 390 pF1KE1 LGALLPGGAVQPTGMHWYSRLLYRLAEELLG ::::::::::::::::::::::::::::::: XP_016 LGALLPGGAVQPTGMHWYSRLLYRLAEELLG 320 330 340 >>XP_016874870 (OMIM: 233420,605423,607080) PREDICTED: d (282 aa) initn: 1934 init1: 1934 opt: 1934 Z-score: 2348.5 bits: 442.9 E(85289): 4.5e-124 Smith-Waterman score: 1934; 100.0% identity (100.0% similar) in 282 aa overlap (115-396:1-282) 90 100 110 120 130 140 pF1KE1 IIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEG :::::::::::::::::::::::::::::: XP_016 MNMWPGVRLRVTEGWDEDGHHAQDSLHYEG 10 20 30 150 160 170 180 190 200 pF1KE1 RALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKADNSLAVRAGGCFPGNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKADNSLAVRAGGCFPGNA 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE1 TVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQRRASFVAVETEWPPRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQRRASFVAVETEWPPRK 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE1 LLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDALRPARVARVAREEAVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDALRPARVARVAREEAVGV 160 170 180 190 200 210 330 340 350 360 370 380 pF1KE1 FAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTGMHWYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTGMHWYS 220 230 240 250 260 270 390 pF1KE1 RLLYRLAEELLG :::::::::::: XP_016 RLLYRLAEELLG 280 >>NP_002172 (OMIM: 112500,600726,607778) indian hedgehog (411 aa) initn: 1475 init1: 1410 opt: 1520 Z-score: 1843.6 bits: 350.0 E(85289): 6e-96 Smith-Waterman score: 1520; 59.9% identity (81.0% similar) in 389 aa overlap (10-395:14-396) 10 20 30 40 50 pF1KE1 MALLTNLLPLCCLALLALPAQ-SCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPER : : ::..:: .::::: :: :: ..:::: :::: :.:::. NP_002 MSPARLRPRLHFCLVLLLLLVVPAAWGCGPGR-VVGSRRRPPRKLVPLAYKQFSPNVPEK 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 TLGASGPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVM :::::: ::..::.::::..:.::::::::::::::.:::::::.:::.:.:.:::.:: NP_002 TLGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVM 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 NMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVY :.::::.:::::::::::::...::::::::.:::::::::::::::::::::::::::: NP_002 NQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVY 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 YESRNHVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVV :::. ::: :::...: :...:::::..: ::: :: : .: .. :: ::: .: . NP_002 YESKAHVHCSVKSEHSAAAKTGGCFPAGAQVRLESGARVALSAVRPGDRVLAMGEDGSPT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 PTPVLLFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLR . ::.::::. .: .: ..::. :::.: ::: ::.:.: . . . : .:: ... NP_002 FSDVLIFLDREPHRLRAFQVIETQDPPRRLALTPAHLLFTADNHTEPAARFRATFASHVQ 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 AGDSVLAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHR :. ::. : .:.::::: :. . :.:..:::: ::::.:.::.:::.:.. .:. :. NP_002 PGQYVLVAGVPGLQPARVAAVSTHVALGAYAPLTKHGTLVVEDVVASCFAAVADHHLAQL 300 310 320 330 340 350 360 370 380 390 pF1KE1 AFAPLRLLHAL--GALLPGGAVQPTGMHWYSRLLYRLAEELLG :: ::::.:.: :. :: :.::: .:::::.. :: NP_002 AFWPLRLFHSLAWGSWTPG-----EGVHWYPQLLYRLGRLLLEEGSFHPLGMSGAGS 360 370 380 390 400 410 >>NP_000184 (OMIM: 142945,147250,269160,600725,611638) s (462 aa) initn: 1421 init1: 1126 opt: 1206 Z-score: 1461.7 bits: 279.5 E(85289): 1.1e-74 Smith-Waterman score: 1456; 58.7% identity (78.2% similar) in 395 aa overlap (1-371:1-392) 10 20 30 40 50 pF1KE1 MALLTNLLPLCCLA-LLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGA : ::. : : .. ::. . .:::::: :.::. .: :.:: ::::.:.: :.:::: NP_000 MLLLARCLLLVLVSSLLVCSGLACGPGRG-FGKRRHPKK-LTPLAYKQFIPNVAEKTLGA 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 SGPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWP :: ::...:.::::..:.::::::::::::::.:::::::.:::...:::::.:::.:: NP_000 SGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 GVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESR ::.:::::::::::::...::::::::.:::::::::.:::.:::::::::::::::::. NP_000 GVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 NHVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPV :.: ::::.::.:...::::::.:::.: .: : ...: :: ::::: .::.. . NP_000 AHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDF 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 LLFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAA---------------RGPAPAPG : ::::: . : ..::. : ..:::: ::.:.: :: :. : NP_000 LTFLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGP-PSGG 240 250 260 270 280 290 290 300 310 320 330 pF1KE1 DFAP--VFARRLRAGDSVLA----PGGDALRPARVARVA-REEAVGVFAPLTAHGTLLVN ..: .:: :.: :. : . : : :: : :. :::.:..:::::.::.:.: NP_000 ALGPRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILIN 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE1 DVLASCYAVLESHQWAHRAFAPLRLLHAL-GALLPGGAVQPTGMHWYSRLLYRLAEELLG ::::::::.: :.::::::::.:: ::: .:: : NP_000 RVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTA 360 370 380 390 400 410 NP_000 PGAADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS 420 430 440 450 460 >>XP_011514782 (OMIM: 142945,147250,269160,600725,611638 (375 aa) initn: 1042 init1: 799 opt: 812 Z-score: 984.9 bits: 191.0 E(85289): 4.1e-48 Smith-Waterman score: 1062; 57.6% identity (76.6% similar) in 295 aa overlap (100-371:12-305) 70 80 90 100 110 120 pF1KE1 GSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGW . :::...:::::.:::.::::.::::::: XP_011 MLSLFPSPGPGSSRCKDKLNALAISVMNQWPGVKLRVTEGW 10 20 30 40 130 140 150 160 170 180 pF1KE1 DEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKAD ::::::...::::::::.:::::::::.:::.:::::::::::::::::. :.: ::::. XP_011 DEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAE 50 60 70 80 90 100 190 200 210 220 230 240 pF1KE1 NSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQR ::.:...::::::.:::.: .: : ...: :: ::::: .::.. . : ::::: XP_011 NSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDDGA 110 120 130 140 150 160 250 260 270 280 290 pF1KE1 RASFVAVETEWPPRKLLLTPWHLVFAA---------------RGPAPAPGDFAP--VFAR . : ..::. : ..:::: ::.:.: :: :. : ..: .:: XP_011 KKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGP-PSGGALGPRALFAS 170 180 190 200 210 220 300 310 320 330 340 pF1KE1 RLRAGDSVLA----PGGDALRPARVARVA-REEAVGVFAPLTAHGTLLVNDVLASCYAVL :.: :. : . : : :: : :. :::.:..:::::.::.:.: ::::::::. XP_011 RVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVLASCYAVI 230 240 250 260 270 280 350 360 370 380 390 pF1KE1 ESHQWAHRAFAPLRLLHAL-GALLPGGAVQPTGMHWYSRLLYRLAEELLG : :.::::::::.:: ::: .:: : XP_011 EEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTAPGAADAPGAG 290 300 310 320 330 340 >>XP_011514781 (OMIM: 142945,147250,269160,600725,611638 (375 aa) initn: 1042 init1: 799 opt: 812 Z-score: 984.9 bits: 191.0 E(85289): 4.1e-48 Smith-Waterman score: 1062; 57.6% identity (76.6% similar) in 295 aa overlap (100-371:12-305) 70 80 90 100 110 120 pF1KE1 GSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGW . :::...:::::.:::.::::.::::::: XP_011 MLSLFPSPGPGSSRCKDKLNALAISVMNQWPGVKLRVTEGW 10 20 30 40 130 140 150 160 170 180 pF1KE1 DEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKAD ::::::...::::::::.:::::::::.:::.:::::::::::::::::. :.: ::::. XP_011 DEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAE 50 60 70 80 90 100 190 200 210 220 230 240 pF1KE1 NSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQR ::.:...::::::.:::.: .: : ...: :: ::::: .::.. . : ::::: XP_011 NSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDDGA 110 120 130 140 150 160 250 260 270 280 290 pF1KE1 RASFVAVETEWPPRKLLLTPWHLVFAA---------------RGPAPAPGDFAP--VFAR . : ..::. : ..:::: ::.:.: :: :. : ..: .:: XP_011 KKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGP-PSGGALGPRALFAS 170 180 190 200 210 220 300 310 320 330 340 pF1KE1 RLRAGDSVLA----PGGDALRPARVARVA-REEAVGVFAPLTAHGTLLVNDVLASCYAVL :.: :. : . : : :: : :. :::.:..:::::.::.:.: ::::::::. XP_011 RVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVLASCYAVI 230 240 250 260 270 280 350 360 370 380 390 pF1KE1 ESHQWAHRAFAPLRLLHAL-GALLPGGAVQPTGMHWYSRLLYRLAEELLG : :.::::::::.:: ::: .:: : XP_011 EEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTAPGAADAPGAG 290 300 310 320 330 340 >>NP_001297391 (OMIM: 142945,147250,269160,600725,611638 (179 aa) initn: 561 init1: 526 opt: 526 Z-score: 642.4 bits: 126.6 E(85289): 4.8e-29 Smith-Waterman score: 533; 55.3% identity (75.0% similar) in 152 aa overlap (100-239:12-162) 70 80 90 100 110 120 pF1KE1 GSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGW . :::...:::::.:::.::::.::::::: NP_001 MLSLFPSPGPGSSRCKDKLNALAISVMNQWPGVKLRVTEGW 10 20 30 40 130 140 150 160 170 180 pF1KE1 DEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKAD ::::::...::::::::.:::::::::.:::.:::::::::::::::::. :.: :::: NP_001 DEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAG 50 60 70 80 90 100 190 200 210 220 230 pF1KE1 N-------SLAVRAG-GCFPG----NATVRLWSGERKGLRELHRGDWVLAADASGRVVPT . . ::. :: :. .: . :.: ... . :.: :. . . NP_001 KERKPLLRDTRYRASRGCSPAPPGRGADFSFRVDGAKSLCKMY-AWWLLPASLMTKCISI 110 120 130 140 150 160 240 250 260 270 280 290 pF1KE1 PVLLFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAG :: NP_001 PVKTCITMYLKLLSLCSIV 170 396 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 09:52:56 2016 done: Sun Nov 6 09:52:58 2016 Total Scan time: 8.680 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]