FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1838, 354 aa 1>>>pF1KE1838 354 - 354 aa - 354 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3208+/-0.000372; mu= 15.7446+/- 0.023 mean_var=63.6614+/-12.444, 0's: 0 Z-trim(112.7): 14 B-trim: 0 in 0/53 Lambda= 0.160745 statistics sampled from 21647 (21660) to 21647 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.635), E-opt: 0.2 (0.254), width: 16 Scan time: 8.210 The best scores are: opt bits E(85289) NP_000296 (OMIM: 602447) serum paraoxonase/arylest ( 354) 2334 550.1 2.7e-156 XP_016867846 (OMIM: 602447) PREDICTED: serum parao ( 284) 1847 437.1 2.2e-122 XP_005250510 (OMIM: 602447) PREDICTED: serum parao ( 286) 1847 437.1 2.2e-122 XP_016867847 (OMIM: 602447) PREDICTED: serum parao ( 268) 1774 420.2 2.6e-117 NP_000437 (OMIM: 168820,612633) serum paraoxonase/ ( 355) 1634 387.8 2e-107 NP_000931 (OMIM: 602720) serum paraoxonase/lactona ( 354) 1608 381.8 1.3e-105 NP_001018171 (OMIM: 602447) serum paraoxonase/aryl ( 342) 1455 346.3 6e-95 >>NP_000296 (OMIM: 602447) serum paraoxonase/arylesteras (354 aa) initn: 2334 init1: 2334 opt: 2334 Z-score: 2927.1 bits: 550.1 E(85289): 2.7e-156 Smith-Waterman score: 2334; 100.0% identity (100.0% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KE1 MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 DNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYAT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 NDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 AHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPS 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 SEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL 310 320 330 340 350 >>XP_016867846 (OMIM: 602447) PREDICTED: serum paraoxona (284 aa) initn: 1847 init1: 1847 opt: 1847 Z-score: 2318.2 bits: 437.1 E(85289): 2.2e-122 Smith-Waterman score: 1847; 100.0% identity (100.0% similar) in 278 aa overlap (77-354:7-284) 50 60 70 80 90 100 pF1KE1 GIEAGSEDIDILPNGLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGF :::::::::::::::::::::::::::::: XP_016 MRAAEHFAPDKPGGILMMDLKEEKPRARELRISRGF 10 20 30 110 120 130 140 150 160 pF1KE1 DLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSV 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE1 NDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGIN 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE1 ISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPN 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE1 GQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLY 220 230 240 250 260 270 350 pF1KE1 HRALYCEL :::::::: XP_016 HRALYCEL 280 >>XP_005250510 (OMIM: 602447) PREDICTED: serum paraoxona (286 aa) initn: 1847 init1: 1847 opt: 1847 Z-score: 2318.1 bits: 437.1 E(85289): 2.2e-122 Smith-Waterman score: 1847; 100.0% identity (100.0% similar) in 278 aa overlap (77-354:9-286) 50 60 70 80 90 100 pF1KE1 GIEAGSEDIDILPNGLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGF :::::::::::::::::::::::::::::: XP_005 MVWLFLVCFAPDKPGGILMMDLKEEKPRARELRISRGF 10 20 30 110 120 130 140 150 160 pF1KE1 DLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSV 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE1 NDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGIN 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE1 ISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPN 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE1 GQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLY 220 230 240 250 260 270 350 pF1KE1 HRALYCEL :::::::: XP_005 HRALYCEL 280 >>XP_016867847 (OMIM: 602447) PREDICTED: serum paraoxona (268 aa) initn: 1774 init1: 1774 opt: 1774 Z-score: 2227.1 bits: 420.2 E(85289): 2.6e-117 Smith-Waterman score: 1774; 100.0% identity (100.0% similar) in 268 aa overlap (87-354:1-268) 60 70 80 90 100 110 pF1KE1 ILPNGLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGI :::::::::::::::::::::::::::::: XP_016 MMDLKEEKPRARELRISRGFDLASFNPHGI 10 20 30 120 130 140 150 160 170 pF1KE1 STFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAH 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE1 FYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYV 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE1 ADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPN 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE1 NPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL 220 230 240 250 260 >>NP_000437 (OMIM: 168820,612633) serum paraoxonase/aryl (355 aa) initn: 1642 init1: 1258 opt: 1634 Z-score: 2049.7 bits: 387.8 E(85289): 2e-107 Smith-Waterman score: 1634; 65.9% identity (89.3% similar) in 355 aa overlap (1-354:1-355) 10 20 30 40 50 60 pF1KE1 MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN :..:.:. :::..:::. .. . ..::.: :::. :.::.:.:.::::.::::..:::: NP_000 MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRG-FDLASFNPHGISTF ::::.: :::.::..:: :..:: ::.:::.:: : . :: :. . ::..:::::::::: NP_000 GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 IDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYA :.:...::.:::::. :.:::.:::.: :.:::::::..:.:::..:::.:::: :::. NP_000 TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 TNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADI :::::: ::.:. : ::.: :. ::::::.::.::::::: ::::::::: ::.:.:.. NP_000 TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE1 LAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPP :::.::: :::.: .:: :: :...:::::.:.:: .::.::::::::.:.: :: .::: NP_000 LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE1 SSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL .::::::::::.:.: :: :::.::.:::::.::::: :::::::..:.:::::: NP_000 ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL 310 320 330 340 350 >>NP_000931 (OMIM: 602720) serum paraoxonase/lactonase 3 (354 aa) initn: 1608 init1: 1608 opt: 1608 Z-score: 2017.2 bits: 381.8 E(85289): 1.3e-105 Smith-Waterman score: 1608; 65.5% identity (89.8% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KE1 MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN ::.:::. :::..:.:.:: .::.:.:..:::::: :. .::::. .:.:::::::::. NP_000 MGKLVALVLLGVGLSLVGEMFLAFRERVNASREVEPVEPENCHLIEELESGSEDIDILPS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFI ::::.: :::.::. .::::.:: :..:::.:..:::. :.:: ::: ::::::: :: NP_000 GLAFISSGLKYPGMPNFAPDEPGKIFLMDLNEQNPRAQALEISGGFDKELFNPHGISIFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 DNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYAT :.:.::::.:::::..:.::::::::: . ::..:::.::::: :::::...:: .:::: NP_000 DKDNTVYLYVVNHPHMKSTVEIFKFEEQQRSLVYLKTIKHELLKSVNDIVVLGPEQFYAT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 NDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADIL ::::.. .:...: :.:.:. :..::: ::::::.:: :::::..: :.::.::::. NP_000 RDHYFTNSLLSFFEMILDLRWTYVLFYSPREVKVVAKGFCSANGITVSADQKYVYVADVA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 AHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPS :..::..::: : .::::::..: ::::::..::..::: .::::: .::. :.:..::. NP_000 AKNIHIMEKHDNWDLTQLKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLNYNPEDPPG 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 SEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL ::::::::.::::: :.::::::::::::.:::::: ::.::::..:..::::: NP_000 SEVLRIQNVLSEKPRVSTVYANNGSVLQGTSVASVYHGKILIGTVFHKTLYCEL 310 320 330 340 350 >>NP_001018171 (OMIM: 602447) serum paraoxonase/aryleste (342 aa) initn: 2267 init1: 1450 opt: 1455 Z-score: 1825.6 bits: 346.3 E(85289): 6e-95 Smith-Waterman score: 2216; 96.6% identity (96.6% similar) in 354 aa overlap (1-354:1-342) 10 20 30 40 50 60 pF1KE1 MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 DNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYAT :: :::::::::::::::::::::::::::::::::::::::::::::: NP_001 DN------------EFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYAT 130 140 150 160 190 200 210 220 230 240 pF1KE1 NDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADIL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE1 AHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPS 230 240 250 260 270 280 310 320 330 340 350 pF1KE1 SEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL 290 300 310 320 330 340 354 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 09:57:27 2016 done: Sun Nov 6 09:57:28 2016 Total Scan time: 8.210 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]