FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5755, 810 aa 1>>>pF1KB5755 810 - 810 aa - 810 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2461+/-0.000371; mu= 16.4982+/- 0.023 mean_var=109.3823+/-21.746, 0's: 0 Z-trim(116.5): 347 B-trim: 0 in 0/60 Lambda= 0.122631 statistics sampled from 27326 (27698) to 27326 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.682), E-opt: 0.2 (0.325), width: 16 Scan time: 8.900 The best scores are: opt bits E(85289) NP_000292 (OMIM: 173350,217090) plasminogen isofor ( 810) 5880 1051.7 0 NP_005568 (OMIM: 152200) apolipoprotein(a) precurs (2040) 2359 429.1 9.3e-119 XP_011532040 (OMIM: 142408) PREDICTED: hepatocyte ( 515) 1109 207.5 1.2e-52 XP_011532039 (OMIM: 142408) PREDICTED: hepatocyte ( 523) 1109 207.5 1.2e-52 NP_066278 (OMIM: 142408) hepatocyte growth factor- ( 725) 1109 207.6 1.6e-52 XP_016861957 (OMIM: 142408) PREDICTED: hepatocyte ( 366) 970 182.8 2.4e-45 NP_001161810 (OMIM: 173350,217090) plasminogen iso ( 136) 907 171.3 2.5e-42 XP_016867586 (OMIM: 142409,608265) PREDICTED: hepa ( 290) 811 154.6 5.8e-37 NP_001010931 (OMIM: 142409,608265) hepatocyte grow ( 290) 811 154.6 5.8e-37 XP_016867587 (OMIM: 142409,608265) PREDICTED: hepa ( 285) 777 148.6 3.7e-35 NP_001010933 (OMIM: 142409,608265) hepatocyte grow ( 285) 777 148.6 3.7e-35 NP_001010932 (OMIM: 142409,608265) hepatocyte grow ( 723) 775 148.5 9.7e-35 XP_011514417 (OMIM: 142409,608265) PREDICTED: hepa ( 723) 775 148.5 9.7e-35 XP_006716019 (OMIM: 142409,608265) PREDICTED: hepa ( 728) 775 148.5 9.7e-35 NP_000592 (OMIM: 142409,608265) hepatocyte growth ( 728) 775 148.5 9.7e-35 NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 681 131.6 5.3e-30 NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 681 131.7 6.9e-30 NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 681 131.7 6.9e-30 XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 678 131.1 8.1e-30 XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 678 131.1 8.1e-30 NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 671 129.9 1.8e-29 NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 659 128.1 1.9e-28 XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 656 127.6 2.8e-28 XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 656 127.6 2.8e-28 XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 656 127.6 2.8e-28 XP_011527956 (OMIM: 226200,606635) PREDICTED: ente (1064) 656 127.6 2.8e-28 XP_011527958 (OMIM: 226200,606635) PREDICTED: ente (1064) 656 127.6 2.8e-28 XP_011527957 (OMIM: 226200,606635) PREDICTED: ente (1064) 656 127.6 2.8e-28 NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 646 125.6 5.9e-28 NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 645 125.4 6.4e-28 NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 645 125.5 6.7e-28 NP_001898 (OMIM: 118888) chymotrypsin-like proteas ( 264) 636 123.6 1.1e-27 NP_001897 (OMIM: 118890) chymotrypsinogen B isofor ( 263) 624 121.5 4.9e-27 NP_254275 (OMIM: 609443) chymotrypsin-like elastas ( 269) 620 120.8 8.2e-27 XP_011532034 (OMIM: 142408) PREDICTED: hepatocyte ( 737) 626 122.2 8.5e-27 XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 612 119.5 2.9e-26 NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 616 120.4 3.1e-26 NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 616 120.4 3.1e-26 XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 612 119.5 3.2e-26 XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 612 119.6 3.5e-26 NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 612 119.6 3.5e-26 NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 612 119.6 3.7e-26 NP_001027564 (OMIM: 173340) plasminogen-like prote ( 96) 600 116.9 4.3e-26 XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 608 118.9 6.2e-26 XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 608 119.0 7.3e-26 NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 605 118.3 7.4e-26 XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 605 118.3 7.4e-26 NP_001182058 (OMIM: 613517,613858) serine protease ( 603) 606 118.6 8.4e-26 NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 605 118.4 9.9e-26 XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 605 118.4 1e-25 >>NP_000292 (OMIM: 173350,217090) plasminogen isoform 1 (810 aa) initn: 5880 init1: 5880 opt: 5880 Z-score: 5625.2 bits: 1051.7 E(85289): 0 Smith-Waterman score: 5880; 99.9% identity (99.9% similar) in 810 aa overlap (1-810:1-810) 10 20 30 40 50 60 pF1KB5 MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 LRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 AQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 QLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 LTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEED 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 CMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 PWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 RFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 PTRKDIALLKLSSPADITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQ ::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: NP_000 PTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQ 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB5 LPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSW 730 740 750 760 770 780 790 800 810 pF1KB5 GLGCARPNKPGVYVRVSRFVTWIEGVMRNN :::::::::::::::::::::::::::::: NP_000 GLGCARPNKPGVYVRVSRFVTWIEGVMRNN 790 800 810 >>NP_005568 (OMIM: 152200) apolipoprotein(a) precursor [ (2040 aa) initn: 2309 init1: 2287 opt: 2359 Z-score: 2253.0 bits: 429.1 E(85289): 9.3e-119 Smith-Waterman score: 3626; 63.9% identity (78.0% similar) in 785 aa overlap (95-810:1266-2040) 70 80 90 100 110 120 pF1KB5 QYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITC :.. ...: :.:..:::..: : .: :: NP_005 RWEYCNLTQCPVTESSVLATSTAVSEQAPTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTC 1240 1250 1260 1270 1280 1290 130 140 150 160 170 180 pF1KB5 QKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILEC--- :.::: .:: . . .:. :: .::::::: . . ::::: :: :..::.. .: NP_005 QSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEIR-PWCYTMDPSVRWEYCNLTQCPVM 1300 1310 1320 1330 1340 1350 190 200 210 pF1KB5 --------------------EE----------ECMHCSGENYDGKISKTMSGLECQAWDS :: .:.. .:..: : .: :..: ::.:.: NP_005 ESTLLTTPTVVPVPSTELPSEEAPTENSTGVQDCYRGDGQSYRGTLSTTITGRTCQSWSS 1360 1370 1380 1390 1400 1410 220 230 240 250 260 pF1KB5 QSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRC--------T ..:: : :: .:: .: .::::::: :.::::.: ::. ::: :.. :: : NP_005 MTPHWHRRIPLYYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLT 1420 1430 1440 1450 1460 1470 270 280 290 300 pF1KB5 TP---------------PPSSGPTYQ-CLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTH :: :: ..:. : : .: :..::: ..::.:.::: ::.. :: : NP_005 TPTVAPVPSTEAPSEQAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWSSMIPHWH 1480 1490 1500 1510 1520 1530 310 320 330 340 350 pF1KB5 NRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSS-----------P .:::::.: .: ::::::::. . :::.::. ::::::.. .:. . : NP_005 QRTPENYPNAGLTENYCRNPDSGKQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVP 1540 1550 1560 1570 1580 1590 360 370 380 390 400 410 pF1KB5 V-STEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPEN : : : . .:: : ::::..::::.::::::: :::.::. :::::::::::::.:::: NP_005 VPSMEAHSEAAPTEQTPVVRQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPEN 1600 1610 1620 1630 1640 1650 420 430 440 450 460 470 pF1KB5 YPNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVET ::: ::::::::::::: :::::: :::.::::::: .:: ::..::::: :. .:.. NP_005 YPNDGLTMNYCRNPDADTGPWCFTMDPSIRWEYCNLTRCSDTEGTVVAPPTVIQVPSLGP 1660 1670 1680 1690 1700 1710 480 490 500 510 520 530 pF1KB5 PSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPD :::.:::::::::::::.::::::::::.:::::::::: : : :: :::::::::::: NP_005 PSEQDCMFGNGKGYRGKKATTVTGTPCQEWAAQEPHRHSTFIPGTNKWAGLEKNYCRNPD 1720 1730 1740 1750 1760 1770 540 550 560 570 580 590 pF1KB5 GDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQ ::..:::::: :::::.::::.: ::. :::::::::::::::: .:::::::::::::: NP_005 GDINGPWCYTMNPRKLFDYCDIPLCASSSFDCGKPQVEPKKCPGSIVGGCVAHPHSWPWQ 1780 1790 1800 1810 1820 1830 600 610 620 630 640 650 pF1KB5 VSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVS :::::::: ::::::::::::::::::::.:: :::::::::::::::::: :::::::: NP_005 VSLRTRFGKHFCGGTLISPEWVLTAAHCLKKSSRPSSYKVILGAHQEVNLESHVQEIEVS 1840 1850 1860 1870 1880 1890 660 670 680 690 700 710 pF1KB5 RLFLEPTRKDIALLKLSSPADITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGL :::::::. :::::::: :: :::::.:::::::.:.:. ::::.::::::::::::.:: NP_005 RLFLEPTQADIALLKLSRPAVITDKVMPACLPSPDYMVTARTECYITGWGETQGTFGTGL 1900 1910 1920 1930 1940 1950 720 730 740 750 760 770 pF1KB5 LKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQ :::::: ::::.:::.:... :: ::: :::::::::::::::::::::::: NP_005 LKEAQLLVIENEVCNHYKYI---------CAEHLARGTDSCQGDSGGPLVCFEKDKYILQ 1960 1970 1980 1990 2000 780 790 800 810 pF1KB5 GVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN ::::::::::::::::::.:::::::::::.:::: NP_005 GVTSWGLGCARPNKPGVYARVSRFVTWIEGMMRNN 2010 2020 2030 2040 >-- initn: 600 init1: 600 opt: 898 Z-score: 856.1 bits: 170.6 E(85289): 6e-41 Smith-Waterman score: 1493; 48.3% identity (69.2% similar) in 439 aa overlap (183-574:26-462) 160 170 180 190 200 210 pF1KB5 RNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQ ..:.: .:..: : : :..: ::::.:. NP_005 MEHKEVVLLLLLFLKSAAPEQSHVVQDCYHGDGQSYRGTYSTTVTGRTCQAWSSM 10 20 30 40 50 220 230 240 250 260 pF1KB5 SPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCT--------- .:: :. ..:: .: ::::::: :.:.: ::. ::: :.. .:. NP_005 TPHQHNRTTENYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAP 60 70 80 90 100 110 270 280 290 300 pF1KB5 ---TPPPS------SGPTYQ------CLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHN :: :: ..:: : : .:.:..:::. ..::.:.::: ::..:::.:. NP_005 PTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHS 120 130 140 150 160 170 310 320 330 340 350 pF1KB5 RTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDS-----------SPV :::: .: .: :::::::. ::.:.: . ::::::.. .:.. .:: NP_005 RTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPV 180 190 200 210 220 230 360 370 380 390 400 410 pF1KB5 -STEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENY : : . :: : : ::.::::.::::::: :::.::. ::.::::::: :..::: : NP_005 PSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYY 240 250 260 270 280 290 420 430 440 450 460 470 pF1KB5 PNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETP ::::: ::::::::: .:.:.: ::.:::::::: .:: .:...:::: :. .:..:.: NP_005 PNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAP 300 310 320 330 340 350 480 490 500 510 520 pF1KB5 SEE----------DCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGL ::. .:. :::..::: .::::: :: :... :: :: ::: : ::: NP_005 SEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHS-RTPEYYPNAGL 360 370 380 390 400 410 530 540 550 560 570 580 pF1KB5 EKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCA-APSFDCGKPQVEPKKCPGRVVGGC :::::::. :..:.::: .: ..::.. ::. : . . : : : NP_005 IMNYCRNPDA-VAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQA 420 430 440 450 460 470 590 600 610 620 630 640 pF1KB5 VAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNL NP_005 PTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYC 480 490 500 510 520 530 >-- initn: 586 init1: 586 opt: 888 Z-score: 846.5 bits: 168.9 E(85289): 2.1e-40 Smith-Waterman score: 1509; 48.5% identity (69.2% similar) in 439 aa overlap (183-574:482-918) 160 170 180 190 200 210 pF1KB5 RNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQ .::.: .:..: : : :..: ::::.:. NP_005 GTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSM 460 470 480 490 500 510 220 230 240 250 260 pF1KB5 SPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCT--------- .::.:. : .:: .: ::::::: :.:.: ::. ::: :.. .:. NP_005 TPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAP 520 530 540 550 560 570 270 280 290 300 pF1KB5 ---TPPPS------SGPTYQ------CLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHN :: :: ..:: : : .:.:..:::. ..::.:.::: ::..:::.:. NP_005 PTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHS 580 590 600 610 620 630 310 320 330 340 350 pF1KB5 RTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDS-----------SPV :::: .: .: :::::::. ::.:.: . ::::::.. .:.. .:: NP_005 RTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPV 640 650 660 670 680 690 360 370 380 390 400 410 pF1KB5 -STEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENY : : . :: : : ::.::::.::::::: :::.::. ::.::::::: :..::: : NP_005 PSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYY 700 710 720 730 740 750 420 430 440 450 460 470 pF1KB5 PNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETP ::::: ::::::::: .:.:.: ::.:::::::: .:: .:...:::: :. .:..:.: NP_005 PNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAP 760 770 780 790 800 810 480 490 500 510 520 pF1KB5 SEE----------DCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGL ::. .:. :::..::: .::::: :: :... :: :: ::: : ::: NP_005 SEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHS-RTPEYYPNAGL 820 830 840 850 860 870 530 540 550 560 570 580 pF1KB5 EKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCA-APSFDCGKPQVEPKKCPGRVVGGC ::::::: :..:.::: .: ..::.. ::. : . . : . : NP_005 IMNYCRNPD-PVAAPYCYTRDPSVRWEYCNLTQCSDAEGTAVAPPTITPIPSLEAPSEQA 880 890 900 910 920 590 600 610 620 630 640 pF1KB5 VAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNL NP_005 PTEQRPGVQECYHGNGQSYQGTYFITVTGRTCQAWSSMTPHSHSRTPAYYPNAGLIKNYC 930 940 950 960 970 980 >-- initn: 558 init1: 558 opt: 884 Z-score: 842.7 bits: 168.2 E(85289): 3.4e-40 Smith-Waterman score: 1196; 51.2% identity (70.5% similar) in 322 aa overlap (183-468:938-1259) 160 170 180 190 200 210 pF1KB5 RNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQ .::.: .:..:.: :..: ::::.:. NP_005 GTAVAPPTITPIPSLEAPSEQAPTEQRPGVQECYHGNGQSYQGTYFITVTGRTCQAWSSM 910 920 930 940 950 960 220 230 240 250 260 pF1KB5 SPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCT-------TP .::.:. :. .:: .: :::::::: :::.::::. ::: :.. ::. .: NP_005 TPHSHSRTPAYYPNAGLIKNYCRNPDPVAAPWCYTTDPSVRWEYCNLTRCSDAEWTAFVP 970 980 990 1000 1010 1020 270 280 290 300 pF1KB5 P-----PS-----------SGPTYQ-CLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHN : :: : : : :..:::. ..::.:.::: ::..::: :. NP_005 PNVILAPSLEAFFEQALTEETPGVQDCYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHS 1030 1040 1050 1060 1070 1080 310 320 330 340 350 360 pF1KB5 RTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSC---DSSPVSTEQLAPT :::::.: .: .:::::::.. :::.: . .::::::.. .: .:: ..: ..: NP_005 RTPENYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCLVTESSVLATLTVVPD 1090 1100 1110 1120 1130 1140 370 380 390 400 410 pF1KB5 ---------APPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENY :: : .: ::::::::::::::. :::.::. :::::::::: ::.: : : NP_005 PSTEASSEEAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYY 1150 1160 1170 1180 1190 1200 420 430 440 450 460 470 pF1KB5 PNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETP ::.::: ::::::::. .:::.: ::.:::::::: .: ::.::.: .: NP_005 PNGGLTRNYCRNPDAEISPWCYTMDPNVRWEYCNLTQCPVTESSVLATSTAVSEQAPTEQ 1210 1220 1230 1240 1250 1260 480 490 500 510 520 530 pF1KB5 SEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDG NP_005 SPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPD 1270 1280 1290 1300 1310 1320 >>XP_011532040 (OMIM: 142408) PREDICTED: hepatocyte grow (515 aa) initn: 1128 init1: 364 opt: 1109 Z-score: 1066.1 bits: 207.5 E(85289): 1.2e-52 Smith-Waterman score: 1439; 43.2% identity (65.3% similar) in 475 aa overlap (9-466:20-474) 10 20 30 pF1KB5 MEHKEVVLLLLLFLKS----GQGEPLDDYVNTQGASLFSVTKK------ ::::. . :: ::.:. .:. : . . XP_011 MGLWWVTVQPPARRMGWLPLLLLLTQCLGVPGQRSPLNDFQVLRGTELQHLLHAVVPGPW 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 QLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAENRKS--SIIIRMRDVVLFEKK : ... ::::..: . ::::.:. . . : .. ...: . . : ::.:: XP_011 QEDVADAEECAGRC--GPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLFQKK 70 80 90 100 110 100 110 120 130 140 150 pF1KB5 VYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDN :. : .:: .:::::. : .:. :: :: :. ...:. . .:::::.:::::. XP_011 DYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLR--NGLEENFCRNPDG 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB5 DPQGPWCYTTDPEKRYDYCDILECEEE-CMHCSGENYDGKISKTMSGLECQAWDSQSPHA :: ::::::::: :.. : : :.: :. :.::.: : ...: :: ::: :: : :: XP_011 DPGGPWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQ 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB5 HGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTP--PPSSGPTYQ : . :.:: ...: ::::::: ::::.::::. . :.::.::: . : . . : . XP_011 HPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEATTVS 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB5 CLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPW :..: ::.:::.. .:..: ::.:.:: :: : :::.. ::.: ::.::::::..::: XP_011 CFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPW 300 310 320 330 340 350 340 350 360 370 380 390 pF1KB5 CHTTNSQVRWEYC-KIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTT : : .: .: .: : :... : :::::: :..:::: : : XP_011 CFTLRPGMRAAFCYQIRRC------TDDVRP----------QDCYHGAGEQYRGTVSKTR 360 370 380 390 400 400 410 420 430 440 450 pF1KB5 TGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADK-GPWCFTTDPSVRWEYCNLK : .:: ::. :::. : : . :.: : :.:::::.:. ::::.: :: . ..:: :. XP_011 KGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALR 410 420 430 440 450 460 460 470 480 490 500 510 pF1KB5 KCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHR .:. . . :: XP_011 RCADDQPPSILDPPDQVQFEKCGKRVDRLDQRRSKLRVVGGHPGNSPWTVSLRNR 470 480 490 500 510 >>XP_011532039 (OMIM: 142408) PREDICTED: hepatocyte grow (523 aa) initn: 1330 init1: 364 opt: 1109 Z-score: 1066.0 bits: 207.5 E(85289): 1.2e-52 Smith-Waterman score: 1444; 41.1% identity (63.6% similar) in 525 aa overlap (9-515:20-518) 10 20 30 pF1KB5 MEHKEVVLLLLLFLKS----GQGEPLDDYVNTQGASLFSVTKK------ ::::. . :: ::.:. .:. : . . XP_011 MGLWWVTVQPPARRMGWLPLLLLLTQCLGVPGQRSPLNDFQVLRGTELQHLLHAVVPGPW 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 QLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAENRKS--SIIIRMRDVVLFEKK : ... ::::..: . ::::.:. . . : .. ...: . . : ::.:: XP_011 QEDVADAEECAGRC--GPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLFQKK 70 80 90 100 110 100 110 120 130 140 150 pF1KB5 VYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDN :. : .:: .:::::. : .:. :: :: :. ...:. . .:::::.:::::. XP_011 DYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLR--NGLEENFCRNPDG 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB5 DPQGPWCYTTDPEKRYDYCDILECEEE-CMHCSGENYDGKISKTMSGLECQAWDSQSPHA :: ::::::::: :.. : : :.: :. :.::.: : ...: :: ::: :: : :: XP_011 DPGGPWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQ 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB5 HGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTP--PPSSGPTYQ : . :.:: ...: ::::::: ::::.::::. . :.::.::: . : . . : . XP_011 HPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEATTVS 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB5 CLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPW :..: ::.:::.. .:..: ::.:.:: :: : :::.. ::.: ::.::::::..::: XP_011 CFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPW 300 310 320 330 340 350 340 350 360 370 380 390 pF1KB5 CHTTNSQVRWEYC-KIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTT : : .: .: .: : :... : :::::: :..:::: : : XP_011 CFTLRPGMRAAFCYQIRRC------TDDVRP----------QDCYHGAGEQYRGTVSKTR 360 370 380 390 400 400 410 420 430 440 450 pF1KB5 TGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADK-GPWCFTTDPSVRWEYCNLK : .:: ::. :::. : : . :.: : :.:::::.:. ::::.: :: . ..:: :. XP_011 KGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALR 410 420 430 440 450 460 460 470 480 490 500 510 pF1KB5 KCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQD-WAAQEPH .:. . :: .: : .. :. . : .. .: : : .. :... . XP_011 RCADDQ------PPSILDPPDQVQFEKCGKRVDRLDQRRSKLRVVGGHPGNSPWTVSLRN 470 480 490 500 510 520 530 540 550 560 570 pF1KB5 RHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQ : :: XP_011 RASISAGGL 520 >>NP_066278 (OMIM: 142408) hepatocyte growth factor-like (725 aa) initn: 1330 init1: 364 opt: 1109 Z-score: 1064.0 bits: 207.6 E(85289): 1.6e-52 Smith-Waterman score: 1885; 38.2% identity (59.4% similar) in 820 aa overlap (9-808:20-723) 10 20 30 pF1KB5 MEHKEVVLLLLLFLKS----GQGEPLDDYVNTQGASLFSVTKK------ ::::. . :: ::.:. .:. : . . NP_066 MGLWWVTVQPPARRMGWLPLLLLLTQCLGVPGQRSPLNDFQVLRGTELQHLLHAVVPGPW 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 QLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAENRKS--SIIIRMRDVVLFEKK : ... ::::..: . ::::.:. . . : .. ...: . . : ::.:: NP_066 QEDVADAEECAGRC--GPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLFQKK 70 80 90 100 110 100 110 120 130 140 150 pF1KB5 VYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDN :. : .:: .:::::. : .:. :: :: :. ...:. . .:::::.:::::. NP_066 DYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLR--NGLEENFCRNPDG 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB5 DPQGPWCYTTDPEKRYDYCDILECEEE-CMHCSGENYDGKISKTMSGLECQAWDSQSPHA :: ::::::::: :.. : : :.: :. :.::.: : ...: :: ::: :: : :: NP_066 DPGGPWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQ 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB5 HGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTP--PPSSGPTYQ : . :.:: ...: ::::::: ::::.::::. . :.::.::: . : . . : . NP_066 HPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEATTVS 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB5 CLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPW :..: ::.:::.. .:..: ::.:.:: :: : :::.. ::.: ::.::::::..::: NP_066 CFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPW 300 310 320 330 340 350 340 350 360 370 380 390 pF1KB5 CHTTNSQVRWEYC-KIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTT : : .: .: .: : :... : :::::: :..:::: : : NP_066 CFTLRPGMRAAFCYQIRRC------TDDVRP----------QDCYHGAGEQYRGTVSKTR 360 370 380 390 400 400 410 420 430 440 450 pF1KB5 TGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADK-GPWCFTTDPSVRWEYCNLK : .:: ::. :::. : : . :.: : :.:::::.:. ::::.: :: . ..:: :. NP_066 KGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALR 410 420 430 440 450 460 460 470 480 490 500 510 pF1KB5 KCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHR .:. . :: .: : .. :. : :::. . .: NP_066 RCADDQ------PPSILDPPDQVQFEK-C---------GKRVDRLD------------QR 470 480 490 520 530 540 550 560 570 pF1KB5 HSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQV .: :: NP_066 RS-----------------------------------KL--------------------- 580 590 600 610 620 630 pF1KB5 EPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRP-S ::::: :: . :: ::::.: :.:::::.:.. .:.::: .:. . : . NP_066 -------RVVGG---HPGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLT 500 510 520 530 540 640 650 660 670 680 pF1KB5 SYKVILGA--HQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPADITDKVIPACLPSP .:.: ::. .. . :: .:.. :... :. ....:::: . ....: ::: NP_066 GYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPSGSQLVLLKLERSVTLNQRVALICLPPE 550 560 570 580 590 600 690 700 710 720 730 740 pF1KB5 NYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHL ::: :.: :.:::::.:: . .:. : : :: :. :: . :::. .:.:. : NP_066 WYVVPPGTKCEIAGWGETKGTGNDTVLNVALLNVISNQECNIKH--RGRVRESEMCTEGL 610 620 630 640 650 660 750 760 770 780 790 800 pF1KB5 AGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRN . . .:.:: ::::.:: .. ..:.:. . ::: :.:..::: :: ::. ::: NP_066 LAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVMRL 670 680 690 700 710 720 810 pF1KB5 N NP_066 G >>XP_016861957 (OMIM: 142408) PREDICTED: hepatocyte grow (366 aa) initn: 931 init1: 364 opt: 970 Z-score: 935.2 bits: 182.8 E(85289): 2.4e-45 Smith-Waterman score: 971; 41.3% identity (64.4% similar) in 351 aa overlap (9-343:20-366) 10 20 30 pF1KB5 MEHKEVVLLLLLFLKS----GQGEPLDDYVNTQGASLFSVTKK------ ::::. . :: ::.:. .:. : . . XP_016 MGLWWVTVQPPARRMGWLPLLLLLTQCLGVPGQRSPLNDFQVLRGTELQHLLHAVVPGPW 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 QLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAENRKS--SIIIRMRDVVLFEKK : ... ::::..: . ::::.:. . . : .. ...: . . : ::.:: XP_016 QEDVADAEECAGRC--GPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLFQKK 70 80 90 100 110 100 110 120 130 140 150 pF1KB5 VYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDN :. : .:: .:::::. : .:. :: :: :. ...:. . .:::::.:::::. XP_016 DYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLR--NGLEENFCRNPDG 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB5 DPQGPWCYTTDPEKRYDYCDILECEEE-CMHCSGENYDGKISKTMSGLECQAWDSQSPHA :: ::::::::: :.. : : :.: :. :.::.: : ...: :: ::: :: : :: XP_016 DPGGPWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQ 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB5 HGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTP--PPSSGPTYQ : . :.:: ...: ::::::: ::::.::::. . :.::.::: . : . . : . XP_016 HPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEATTVS 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB5 CLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNP-DGKRAP :..: ::.:::.. .:..: ::.:.:: :: : :::.. :: : . : :.. : XP_016 CFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKLLPRRRGAVPRHGQQDP 300 310 320 330 340 350 340 350 360 370 380 390 pF1KB5 WCHTTNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTT . . :: XP_016 QGCPVPALVR 360 >>NP_001161810 (OMIM: 173350,217090) plasminogen isoform (136 aa) initn: 907 init1: 907 opt: 907 Z-score: 880.9 bits: 171.3 E(85289): 2.5e-42 Smith-Waterman score: 907; 100.0% identity (100.0% similar) in 136 aa overlap (1-136:1-136) 10 20 30 40 50 60 pF1KB5 MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILE :::::::::::::::: NP_001 GITCQKWSSTSPHRPR 130 >>XP_016867586 (OMIM: 142409,608265) PREDICTED: hepatocy (290 aa) initn: 855 init1: 373 opt: 811 Z-score: 784.6 bits: 154.6 E(85289): 5.8e-37 Smith-Waterman score: 811; 45.1% identity (70.8% similar) in 233 aa overlap (37-264:61-290) 10 20 30 40 50 60 pF1KB5 VLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDE--EFTCRAF ::: ... ..:: .: ... :::.:: XP_016 GQRKRRNTIHEFKKSAKTTLIKIDPALKIKTKK---VNTADQCANRCTRNKGLPFTCKAF 40 50 60 70 80 70 80 90 100 110 120 pF1KB5 QYHSKEQQCVIMAENRKSSIIIRM--RDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGI . . ..::. . : :: . . .. :.:.: :. .: :.:..:.::.: ::.:: XP_016 VFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGI 90 100 110 120 130 140 130 140 150 160 170 180 pF1KB5 TCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECE :: ::: ::. : :... .. :.::::::: .. ::::.:..:: ::. ::: .: XP_016 KCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCS 150 160 170 180 190 200 190 200 210 220 230 240 pF1KB5 E-ECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDREL : ::: :.::.: : ...: :: :: :: :.:: : ..: ..:.:.. ::::::: . XP_016 EVECMTCNGESYRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQP 210 220 230 240 250 260 250 260 270 280 290 300 pF1KB5 RPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSA ::::.: ::. ::: : : : : XP_016 RPWCYTLDPHTRWEYCAIKTCET 270 280 290 >>NP_001010931 (OMIM: 142409,608265) hepatocyte growth f (290 aa) initn: 855 init1: 373 opt: 811 Z-score: 784.6 bits: 154.6 E(85289): 5.8e-37 Smith-Waterman score: 811; 45.1% identity (70.8% similar) in 233 aa overlap (37-264:61-290) 10 20 30 40 50 60 pF1KB5 VLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDE--EFTCRAF ::: ... ..:: .: ... :::.:: NP_001 GQRKRRNTIHEFKKSAKTTLIKIDPALKIKTKK---VNTADQCANRCTRNKGLPFTCKAF 40 50 60 70 80 70 80 90 100 110 120 pF1KB5 QYHSKEQQCVIMAENRKSSIIIRM--RDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGI . . ..::. . : :: . . .. :.:.: :. .: :.:..:.::.: ::.:: NP_001 VFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGI 90 100 110 120 130 140 130 140 150 160 170 180 pF1KB5 TCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECE :: ::: ::. : :... .. :.::::::: .. ::::.:..:: ::. ::: .: NP_001 KCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCS 150 160 170 180 190 200 190 200 210 220 230 240 pF1KB5 E-ECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDREL : ::: :.::.: : ...: :: :: :: :.:: : ..: ..:.:.. ::::::: . NP_001 EVECMTCNGESYRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQP 210 220 230 240 250 260 250 260 270 280 290 300 pF1KB5 RPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSA ::::.: ::. ::: : : : : NP_001 RPWCYTLDPHTRWEYCAIKTCET 270 280 290 >>XP_016867587 (OMIM: 142409,608265) PREDICTED: hepatocy (285 aa) initn: 1190 init1: 373 opt: 777 Z-score: 752.2 bits: 148.6 E(85289): 3.7e-35 Smith-Waterman score: 777; 44.2% identity (69.1% similar) in 233 aa overlap (37-264:61-285) 10 20 30 40 50 60 pF1KB5 VLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDE--EFTCRAF ::: ... ..:: .: ... :::.:: XP_016 GQRKRRNTIHEFKKSAKTTLIKIDPALKIKTKK---VNTADQCANRCTRNKGLPFTCKAF 40 50 60 70 80 70 80 90 100 110 120 pF1KB5 QYHSKEQQCVIMAENRKSSIIIRM--RDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGI . . ..::. . : :: . . .. :.:.: :. .: :.:..:.::.: ::.:: XP_016 VFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGI 90 100 110 120 130 140 130 140 150 160 170 180 pF1KB5 TCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECE :: ::: ::. . .. :.::::::: .. ::::.:..:: ::. ::: .: XP_016 KCQPWSSMIPHEHSYR-----GKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCS 150 160 170 180 190 200 190 200 210 220 230 240 pF1KB5 E-ECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDREL : ::: :.::.: : ...: :: :: :: :.:: : ..: ..:.:.. ::::::: . XP_016 EVECMTCNGESYRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQP 210 220 230 240 250 260 250 260 270 280 290 300 pF1KB5 RPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSA ::::.: ::. ::: : : : : XP_016 RPWCYTLDPHTRWEYCAIKTCET 270 280 810 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 17:14:40 2016 done: Tue Nov 8 17:14:42 2016 Total Scan time: 8.900 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]