FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1935, 474 aa 1>>>pF1KE1935 474 - 474 aa - 474 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7775+/-0.000374; mu= 15.7325+/- 0.023 mean_var=77.1275+/-15.105, 0's: 0 Z-trim(113.2): 38 B-trim: 0 in 0/53 Lambda= 0.146039 statistics sampled from 22466 (22490) to 22466 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.264), width: 16 Scan time: 9.610 The best scores are: opt bits E(85289) NP_001191235 (OMIM: 139200) vitamin D-binding prot ( 474) 3171 677.8 1.7e-194 NP_000574 (OMIM: 139200) vitamin D-binding protein ( 474) 3171 677.8 1.7e-194 NP_001191236 (OMIM: 139200) vitamin D-binding prot ( 493) 3171 677.8 1.8e-194 XP_006714240 (OMIM: 139200) PREDICTED: vitamin D-b ( 425) 2841 608.3 1.3e-173 NP_000468 (OMIM: 103600,615999,616000) serum album ( 609) 595 135.1 5.1e-31 XP_016863331 (OMIM: 104145) PREDICTED: afamin isof ( 494) 299 72.7 2.6e-12 XP_016863333 (OMIM: 104145) PREDICTED: afamin isof ( 423) 233 58.8 3.4e-08 XP_016863332 (OMIM: 104145) PREDICTED: afamin isof ( 425) 233 58.8 3.5e-08 NP_001124 (OMIM: 104145) afamin precursor [Homo sa ( 599) 229 58.0 8.3e-08 NP_001125 (OMIM: 104150,615969,615970) alpha-fetop ( 609) 220 56.1 3.1e-07 >>NP_001191235 (OMIM: 139200) vitamin D-binding protein (474 aa) initn: 3171 init1: 3171 opt: 3171 Z-score: 3612.6 bits: 677.8 E(85289): 1.7e-194 Smith-Waterman score: 3171; 99.6% identity (100.0% similar) in 474 aa overlap (1-474:1-474) 10 20 30 40 50 60 pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK 370 380 390 400 410 420 430 440 450 460 470 pF1KE1 KLAERLKAKLPEATPTELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNIL :::::::::::.::::::::::::.::::::::::::::::::::::::::::: NP_001 KLAERLKAKLPDATPTELAKLVNKHSDFASNCCSINSPPLYCDSEIDAELKNIL 430 440 450 460 470 >>NP_000574 (OMIM: 139200) vitamin D-binding protein iso (474 aa) initn: 3171 init1: 3171 opt: 3171 Z-score: 3612.6 bits: 677.8 E(85289): 1.7e-194 Smith-Waterman score: 3171; 99.6% identity (100.0% similar) in 474 aa overlap (1-474:1-474) 10 20 30 40 50 60 pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK 370 380 390 400 410 420 430 440 450 460 470 pF1KE1 KLAERLKAKLPEATPTELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNIL :::::::::::.::::::::::::.::::::::::::::::::::::::::::: NP_000 KLAERLKAKLPDATPTELAKLVNKHSDFASNCCSINSPPLYCDSEIDAELKNIL 430 440 450 460 470 >>NP_001191236 (OMIM: 139200) vitamin D-binding protein (493 aa) initn: 3171 init1: 3171 opt: 3171 Z-score: 3612.4 bits: 677.8 E(85289): 1.8e-194 Smith-Waterman score: 3171; 99.6% identity (100.0% similar) in 474 aa overlap (1-474:20-493) 10 20 30 40 pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFT ::::::::::::::::::::::::::::::::::::::::: NP_001 MLWSWSEERGGAARLSGRKMKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFT 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 SLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSP 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE1 FPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMW 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE1 EYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCS 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE1 QYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEH 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE1 TVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTK 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE1 VMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFID 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE1 KGQELCADYSENTFTEYKKKLAERLKAKLPEATPTELAKLVNKRSDFASNCCSINSPPLY ::::::::::::::::::::::::::::::.::::::::::::.:::::::::::::::: NP_001 KGQELCADYSENTFTEYKKKLAERLKAKLPDATPTELAKLVNKHSDFASNCCSINSPPLY 430 440 450 460 470 480 470 pF1KE1 CDSEIDAELKNIL ::::::::::::: NP_001 CDSEIDAELKNIL 490 >>XP_006714240 (OMIM: 139200) PREDICTED: vitamin D-bindi (425 aa) initn: 2841 init1: 2841 opt: 2841 Z-score: 3237.6 bits: 608.3 E(85289): 1.3e-173 Smith-Waterman score: 2841; 100.0% identity (100.0% similar) in 422 aa overlap (1-422:1-422) 10 20 30 40 50 60 pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK 370 380 390 400 410 420 430 440 450 460 470 pF1KE1 KLAERLKAKLPEATPTELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNIL :: XP_006 KLMLN >>NP_000468 (OMIM: 103600,615999,616000) serum albumin p (609 aa) initn: 424 init1: 302 opt: 595 Z-score: 677.8 bits: 135.1 E(85289): 5.1e-31 Smith-Waterman score: 598; 24.9% identity (58.1% similar) in 470 aa overlap (1-453:1-462) 10 20 30 40 50 pF1KE1 MKRVLVLLLAVAFGHALERG---RDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTF :: : . : :. : :: :: .:..: ..:. ::.:.: .: :. ... . . : NP_000 MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 EQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGL :. .::.::. ....: :. . .: . . .. : : . .. :.::.:. NP_000 EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 ERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVS ::. :. : . ..: :.: : .: ::. . . . .....: . . :. NP_000 ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 YTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRV-CSQYAAYGEKKSRLSNL ..: : . :: .:. ..:.: . .:. . .. ..:. :.. .::. . . NP_000 FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE1 IKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKF .:.:. : :.. .: :. :.:.. ..::.. .: : . . . .:.: .. .::. NP_000 ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLEC-ADDRADLAKYICENQDSISSKL 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 EDCCQEKTAMDVFVCTYFMPAAQLP-ELPDV--ELPTNKDVC-DPGNTK--VMDKYTFEL ..:: :: .. : . ..: .::.. .. .:::: . ...: . . .: NP_000 KECC-EKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEY 300 310 320 330 340 350 360 370 380 390 400 pF1KE1 SRRTHLPE---VFLSKVLEPTLKSLGECCDVEDSTTC----FNAKGPLLKKELSSFIDKG .:: : :. :.: .. . .: .:: . : : :. ::.. : ...: .. NP_000 ARR-H-PDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVE-EPQNLIKQN 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE1 QELCADYSENTFTEYKKKLAERLKAKLPEATPTELAKLVNKRSDFASNCCSINSPPLYCD :: . .: : .. : : :.:... :... . . .:.:: NP_000 CELFEQLGEYKF---QNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPC 420 430 440 450 460 470 470 pF1KE1 SEIDAELKNIL NP_000 AEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFT 480 490 500 510 520 530 >>XP_016863331 (OMIM: 104145) PREDICTED: afamin isoform (494 aa) initn: 230 init1: 147 opt: 299 Z-score: 342.1 bits: 72.7 E(85289): 2.6e-12 Smith-Waterman score: 299; 21.0% identity (55.8% similar) in 267 aa overlap (10-271:206-467) 10 20 30 pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKED :. . :. .:.:. :: . ..: . XP_016 PTLLTVAVHFEEVAKSCCEEQNKVNCLQTRAIPVTQYLKAFSSYQKH-VCGALLKFGTKV 180 190 200 210 220 230 40 50 60 70 80 90 pF1KE1 FTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESN . ... :.:::. :... .::..: : ..:: :: .: ..... ... XP_016 VHFIYIAILSQKFPKIEFKELISLVEDVSSNYDGCC-EGDVVQCIRDTSKVMNHICSKQD 240 250 260 270 280 290 100 110 120 130 140 150 pF1KE1 SPFPVHPGTAECCTKEGLERKLCMAALKH--QPQEFPTYVEPTND--EICEAFRKDPKEY : . ::: :. :: :. .. .:... .: ..:. :: . XP_016 S---ISSKIKECCEKKIPERGQCIINSNKDDRPKDLSLREGKFTDSENVCQERDADPDTF 300 310 320 330 340 350 160 170 180 190 200 210 pF1KE1 ANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTT- .: .::: . . . :. .. : ... .::.. .: :. . .... . . XP_016 FAKFTFEYSRRHPDLSIPELLRIVQIYKDLLRNCCNTENPPGCYRYAEDKFNETTEKSLK 360 370 380 390 400 410 220 230 240 250 260 270 pF1KE1 LSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCM . .. :... :. . ::.:.. .: . :... :.: ... .. :: . : XP_016 MVQQECKHFQNLGKDGLKYHYLIRLTKIAPQLSTEELVSLGEKMVTAFTTCCTLSEEFAC 420 430 440 450 460 470 280 290 300 310 320 330 pF1KE1 AKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDV XP_016 VDNLTCVNLRMRSFRGRQTGFLST 480 490 >-- initn: 127 init1: 62 opt: 222 Z-score: 254.5 bits: 56.5 E(85289): 2e-07 Smith-Waterman score: 222; 23.1% identity (57.7% similar) in 182 aa overlap (21-199:27-202) 10 20 30 40 50 pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPS :: :. . ..: .... .... ... XP_016 MKLLKLTGFIFFLFFLTESLTLPTQPRDIENFNSTQKFI---EDNIEYITIIAFAQYVQE 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 GTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTK .:::.. .:::..: . : :. . :.: ...:. : : .. .: . . ..::.: XP_016 ATFEEMEKLVKDMVEYKDRCMADKTLPECSKLPNNVLQEKICAMEG-LPQKHNFSHCCSK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 EGLERKLCMAALKHQPQEF-PTYVEPTND--EICEAFRKDPKEYANQFMWEYSTNYGQAP .:.::. :.. : : . :: : : :.:.... . :.:..: . . XP_016 VDAQRRLCFFYNKKSDVGFLPPF--PTLDPEEKCQAYESNRESLLNHFLYEVARRNPFVF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 LSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKS :.. . . .. ::: . . :. XP_016 APTLLTVAVHFEEVAKSCCEEQNKVNCLQTRAIPVTQYLKAFSSYQKHVCGALLKFGTKV 180 190 200 210 220 230 >>XP_016863333 (OMIM: 104145) PREDICTED: afamin isoform (423 aa) initn: 298 init1: 133 opt: 233 Z-score: 268.0 bits: 58.8 E(85289): 3.4e-08 Smith-Waterman score: 257; 23.0% identity (55.3% similar) in 226 aa overlap (170-385:175-394) 140 150 160 170 180 190 pF1KE1 TNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCF :: : :. . .. ::: . . :. XP_016 EEKCQAYESNRESLLNHFLYEVARRNPFVFAPTLLTVAV--HFEEVAKSCCEEQNKVNCL 150 160 170 180 190 200 200 210 220 230 240 250 pF1KE1 LKERLQL-KHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDI . . . ..:. ... ...::. .: : .. . :.:: : ...... :.::. XP_016 QTRAIPVTQYLKAFSSYQKHVCGALLKFGTKVVHFIYIAILSQKFPKIEFKELISLVEDV 210 220 230 240 250 260 260 270 280 290 300 310 pF1KE1 TNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAA .. . :::. .:. .. . ..:.. .. .::...:: :: . : XP_016 SSNYDGCCEGDVVQCI-RDTSKVMNHICSKQDSISSKIKECC-EKKIPERGQCIINSNKD 270 280 290 300 310 320 320 330 340 350 360 pF1KE1 QLPE---LPDVELPTNKDVC---DPGNTKVMDKYTFELSRR---THLPEVFLSKVLEPTL . :. : . .. ...:: : . :.::: ::: .:: : .... XP_016 DRPKDLSLREGKFTDSENVCQERDADPDTFFAKFTFEYSRRHPDLSIPE--LLRIVQIYK 330 340 350 360 370 370 380 390 400 410 420 pF1KE1 KSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAK : .::..:. :. XP_016 DLLRNCCNTENPPGCYRYAEDKFNETTEKSLKMVQQEFTSSGSRR 380 390 400 410 420 >-- initn: 111 init1: 62 opt: 199 Z-score: 229.3 bits: 51.6 E(85289): 4.9e-06 Smith-Waterman score: 199; 25.5% identity (61.4% similar) in 145 aa overlap (21-162:27-165) 10 20 30 40 50 pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPS :: :. . ..: .... .... ... XP_016 MKLLKLTGFIFFLFFLTESLTLPTQPRDIENFNSTQKFI---EDNIEYITIIAFAQYVQE 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 GTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTK .:::.. .:::..: . : :. . :.: ...:. : : .. .: . . ..::.: XP_016 ATFEEMEKLVKDMVEYKDRCMADKTLPECSKLPNNVLQEKICAMEG-LPQKHNFSHCCSK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 EGLERKLCMAALKHQPQEF-PTYVEPTND--EICEAFRKDPKEYANQFMWEYSTNYGQAP .:.::. :.. : : . :: : : :.:.... . :.:..: XP_016 VDAQRRLCFFYNKKSDVGFLPPF--PTLDPEEKCQAYESNRESLLNHFLYEVARRNPFVF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 LSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKS XP_016 APTLLTVAVHFEEVAKSCCEEQNKVNCLQTRAIPVTQYLKAFSSYQKHVCGALLKFGTKV 180 190 200 210 220 230 >>XP_016863332 (OMIM: 104145) PREDICTED: afamin isoform (425 aa) initn: 298 init1: 133 opt: 233 Z-score: 268.0 bits: 58.8 E(85289): 3.5e-08 Smith-Waterman score: 257; 23.0% identity (55.3% similar) in 226 aa overlap (170-385:175-394) 140 150 160 170 180 190 pF1KE1 TNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCF :: : :. . .. ::: . . :. XP_016 EEKCQAYESNRESLLNHFLYEVARRNPFVFAPTLLTVAV--HFEEVAKSCCEEQNKVNCL 150 160 170 180 190 200 200 210 220 230 240 250 pF1KE1 LKERLQL-KHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDI . . . ..:. ... ...::. .: : .. . :.:: : ...... :.::. XP_016 QTRAIPVTQYLKAFSSYQKHVCGALLKFGTKVVHFIYIAILSQKFPKIEFKELISLVEDV 210 220 230 240 250 260 260 270 280 290 300 310 pF1KE1 TNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAA .. . :::. .:. .. . ..:.. .. .::...:: :: . : XP_016 SSNYDGCCEGDVVQCI-RDTSKVMNHICSKQDSISSKIKECC-EKKIPERGQCIINSNKD 270 280 290 300 310 320 320 330 340 350 360 pF1KE1 QLPE---LPDVELPTNKDVC---DPGNTKVMDKYTFELSRR---THLPEVFLSKVLEPTL . :. : . .. ...:: : . :.::: ::: .:: : .... XP_016 DRPKDLSLREGKFTDSENVCQERDADPDTFFAKFTFEYSRRHPDLSIPE--LLRIVQIYK 330 340 350 360 370 370 380 390 400 410 420 pF1KE1 KSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAK : .::..:. :. XP_016 DLLRNCCNTENPPGCYRYAEDKFNETTEKSLKMLPHQAHEDSSPTLH 380 390 400 410 420 >-- initn: 111 init1: 62 opt: 199 Z-score: 229.3 bits: 51.6 E(85289): 5e-06 Smith-Waterman score: 199; 25.5% identity (61.4% similar) in 145 aa overlap (21-162:27-165) 10 20 30 40 50 pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPS :: :. . ..: .... .... ... XP_016 MKLLKLTGFIFFLFFLTESLTLPTQPRDIENFNSTQKFI---EDNIEYITIIAFAQYVQE 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 GTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTK .:::.. .:::..: . : :. . :.: ...:. : : .. .: . . ..::.: XP_016 ATFEEMEKLVKDMVEYKDRCMADKTLPECSKLPNNVLQEKICAMEG-LPQKHNFSHCCSK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 EGLERKLCMAALKHQPQEF-PTYVEPTND--EICEAFRKDPKEYANQFMWEYSTNYGQAP .:.::. :.. : : . :: : : :.:.... . :.:..: XP_016 VDAQRRLCFFYNKKSDVGFLPPF--PTLDPEEKCQAYESNRESLLNHFLYEVARRNPFVF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 LSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKS XP_016 APTLLTVAVHFEEVAKSCCEEQNKVNCLQTRAIPVTQYLKAFSSYQKHVCGALLKFGTKV 180 190 200 210 220 230 >>NP_001124 (OMIM: 104145) afamin precursor [Homo sapien (599 aa) initn: 266 init1: 159 opt: 229 Z-score: 261.2 bits: 58.0 E(85289): 8.3e-08 Smith-Waterman score: 257; 23.0% identity (55.3% similar) in 226 aa overlap (170-385:175-394) 140 150 160 170 180 190 pF1KE1 TNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCF :: : :. . .. ::: . . :. NP_001 EEKCQAYESNRESLLNHFLYEVARRNPFVFAPTLLTVAV--HFEEVAKSCCEEQNKVNCL 150 160 170 180 190 200 200 210 220 230 240 250 pF1KE1 LKERLQL-KHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDI . . . ..:. ... ...::. .: : .. . :.:: : ...... :.::. NP_001 QTRAIPVTQYLKAFSSYQKHVCGALLKFGTKVVHFIYIAILSQKFPKIEFKELISLVEDV 210 220 230 240 250 260 260 270 280 290 300 310 pF1KE1 TNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAA .. . :::. .:. .. . ..:.. .. .::...:: :: . : NP_001 SSNYDGCCEGDVVQCI-RDTSKVMNHICSKQDSISSKIKECC-EKKIPERGQCIINSNKD 270 280 290 300 310 320 320 330 340 350 360 pF1KE1 QLPE---LPDVELPTNKDVC---DPGNTKVMDKYTFELSRR---THLPEVFLSKVLEPTL . :. : . .. ...:: : . :.::: ::: .:: : .... NP_001 DRPKDLSLREGKFTDSENVCQERDADPDTFFAKFTFEYSRRHPDLSIPE--LLRIVQIYK 330 340 350 360 370 370 380 390 400 410 420 pF1KE1 KSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAK : .::..:. :. NP_001 DLLRNCCNTENPPGCYRYAEDKFNETTEKSLKMVQQECKHFQNLGKDGLKYHYLIRLTKI 380 390 400 410 420 430 >-- initn: 266 init1: 159 opt: 229 Z-score: 261.2 bits: 58.0 E(85289): 8.3e-08 Smith-Waterman score: 229; 21.9% identity (55.6% similar) in 178 aa overlap (29-202:416-593) 10 20 30 40 50 pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFE ::.:..:::. . :. .. :. . : NP_001 NTENPPGCYRYAEDKFNETTEKSLKMVQQECKHFQNLGKDGLKYHYLIRLTKIAPQLSTE 390 400 410 420 430 440 60 70 80 90 100 110 pF1KE1 QVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLE .. .: ...:. .::. . . : :. .. . .. : : ..:.. .:: . NP_001 ELVSLGEKMVTAFTTCCTLSEEFACVDNLADLVFGELCGVNENRTINPAVDHCCKTNFAF 450 460 470 480 490 500 120 130 140 150 160 170 pF1KE1 RKLCMAALK----HQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSL :. :. .:: . : : . . ..:.. .. .. ...:. . . NP_001 RRPCFESLKADKTYVPPPFSQDLFTFHADMCQSQNEELQRKTDRFLVNLVKLKHELTDEE 510 520 530 540 550 560 180 190 200 210 220 230 pF1KE1 LVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLS : : .. ..: .:: . :: ::: .: NP_001 LQSLFTNFANVVDKCCKAESPEVCFNEESPKIGN 570 580 590 >-- initn: 111 init1: 62 opt: 199 Z-score: 227.0 bits: 51.7 E(85289): 6.6e-06 Smith-Waterman score: 199; 25.5% identity (61.4% similar) in 145 aa overlap (21-162:27-165) 10 20 30 40 50 pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPS :: :. . ..: .... .... ... NP_001 MKLLKLTGFIFFLFFLTESLTLPTQPRDIENFNSTQKFI---EDNIEYITIIAFAQYVQE 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 GTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTK .:::.. .:::..: . : :. . :.: ...:. : : .. .: . . ..::.: NP_001 ATFEEMEKLVKDMVEYKDRCMADKTLPECSKLPNNVLQEKICAMEG-LPQKHNFSHCCSK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 EGLERKLCMAALKHQPQEF-PTYVEPTND--EICEAFRKDPKEYANQFMWEYSTNYGQAP .:.::. :.. : : . :: : : :.:.... . :.:..: NP_001 VDAQRRLCFFYNKKSDVGFLPPF--PTLDPEEKCQAYESNRESLLNHFLYEVARRNPFVF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 LSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKS NP_001 APTLLTVAVHFEEVAKSCCEEQNKVNCLQTRAIPVTQYLKAFSSYQKHVCGALLKFGTKV 180 190 200 210 220 230 >>NP_001125 (OMIM: 104150,615969,615970) alpha-fetoprote (609 aa) initn: 216 init1: 124 opt: 220 Z-score: 250.8 bits: 56.1 E(85289): 3.1e-07 Smith-Waterman score: 360; 21.4% identity (58.6% similar) in 304 aa overlap (5-304:9-307) 10 20 30 40 50 pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGT :..:: . ...:.:. .: .. .. .. ....:. ..... .: NP_001 MKWVESIFLIFLLNFTESRTLHRN-EYGIASILDSYQCTAEISLADLATIFFAQFVQEAT 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 FEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEG ...::..::.... : .. . : ... :. . :. . . . : ..::.. NP_001 YKEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKY-GHSDCCSQSE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 LERKLC-MAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYG--QAPLS :. : .: : : .: . : :::...: . . :.:..: . . :: NP_001 EGRHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMNKFIYEIARRHPFLYAPTI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 LLVSYTKSYLSMVGSCCTSASPTVCF-LKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSR :: .. : ... ::: . . . :: : :.: . :....:. . .: . . NP_001 LL--WAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSLLNQHACAVMKNFGTRTFQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 LSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTK .. ::.:: ... .. :. :.... .::.. ::. .. . .:.. .: NP_001 AITVTKLSQKFTKVNFTEIQKLVLDVAHVHEHCCRGDVLDCL-QDGEKIMSYICSQQDTL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 NSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSR ..:. .::. : NP_001 SNKITECCKLTTLERGQCIIHAENDEKPEGLSPNLNRFLGDRDFNQFSSGEKNIFLASFV 300 310 320 330 340 350 >-- initn: 181 init1: 67 opt: 209 Z-score: 238.3 bits: 53.8 E(85289): 1.6e-06 Smith-Waterman score: 209; 21.0% identity (53.2% similar) in 186 aa overlap (27-206:414-599) 10 20 30 40 50 pF1KE1 MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGT . : :..::. . . :: :..: :. : NP_001 CFQTENPLECQDKGEEELQKYIQESQALAKRSCGLFQKLGEYYLQNAFLVAYTKKAPQLT 390 400 410 420 430 440 60 70 80 90 100 110 pF1KE1 FEQVSQLVKEVVSLTEACCAEGADP--DCYDTRTSALSAKSCESNSPFPVHPGTAECCTK .. ....... . .:: . : : . .. . .. : . ::.::...:::. NP_001 SSELMAITRKMAATAATCCQLSEDKLLACGEGAADIIIGHLCIRHEMTPVNPGVGQCCTS 450 460 470 480 490 500 120 130 140 150 160 170 pF1KE1 EGLERKLCMAAL----KHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQA .:. :...: . : : . ..:.: . . ..:. . . : NP_001 SYANRRPCFSSLVVDETYVPPAFSDDKFIFHKDLCQAQGVALQTMKQEFLINLVKQKPQI 510 520 530 540 550 560 180 190 200 210 220 230 pF1KE1 PLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKK : . .. ... .:: . ::: .: .: NP_001 TEEQLEAVIADFSGLLEKCCQGQEQEVCFAEEGQKLISKTRAALGV 570 580 590 600 240 250 260 270 280 290 pF1KE1 SRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLS 474 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 10:02:12 2016 done: Sun Nov 6 10:02:13 2016 Total Scan time: 9.610 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]