FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6285, 279 aa 1>>>pF1KE6285 279 - 279 aa - 279 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0335+/-0.000367; mu= 16.6479+/- 0.023 mean_var=67.4449+/-14.061, 0's: 0 Z-trim(112.8): 12 B-trim: 0 in 0/50 Lambda= 0.156171 statistics sampled from 21911 (21923) to 21911 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.65), E-opt: 0.2 (0.257), width: 16 Scan time: 5.650 The best scores are: opt bits E(85289) NP_001670 (OMIM: 601867) sodium/potassium-transpor ( 279) 1896 436.1 3.5e-122 NP_001669 (OMIM: 182331) sodium/potassium-transpor ( 290) 597 143.4 4.6e-34 NP_000696 (OMIM: 137217) potassium-transporting AT ( 291) 457 111.9 1.4e-24 NP_001290192 (OMIM: 182331) sodium/potassium-trans ( 208) 419 103.2 4.2e-22 NP_001668 (OMIM: 145500,182330) sodium/potassium-t ( 303) 317 80.4 4.7e-15 >>NP_001670 (OMIM: 601867) sodium/potassium-transporting (279 aa) initn: 1896 init1: 1896 opt: 1896 Z-score: 2314.5 bits: 436.1 E(85289): 3.5e-122 Smith-Waterman score: 1896; 100.0% identity (100.0% similar) in 279 aa overlap (1-279:1-279) 10 20 30 40 50 60 pF1KE6 MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 MLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 EQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LKPEGVPRIDCVSKNEDIPNVAVYPHNGMIDLKYFPYYGKKLHVGYLQPLVAVQVSFAPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKPEGVPRIDCVSKNEDIPNVAVYPHNGMIDLKYFPYYGKKLHVGYLQPLVAVQVSFAPN 190 200 210 220 230 240 250 260 270 pF1KE6 NTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA ::::::::::::::::::::::::::::::::::::::: NP_001 NTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA 250 260 270 >>NP_001669 (OMIM: 182331) sodium/potassium-transporting (290 aa) initn: 817 init1: 385 opt: 597 Z-score: 732.5 bits: 143.4 E(85289): 4.6e-34 Smith-Waterman score: 863; 47.6% identity (73.6% similar) in 288 aa overlap (3-275:4-285) 10 20 30 40 50 pF1KE6 MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMW ..:::: .: . ::: :..:: : .:.:::. ::..::::::::::::.:.:..::: NP_001 MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMW 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 VMLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPY-- :::::..:..:::.:.. .::::. :: . :. . :: :. ... :.:::.:: NP_001 VMLQTVSDHTPKYQDRLATPGLMIRPK-TENLDVIVNVSDTESWDQHVQKLNKFLEPYND 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 TLEEQKNLTVCPDGALFEQ--KGPVYV---ACQFPISLLQACSGMNDPD-FGYSQGNPCI ... ::: :: : .:: .: . :::: . : :::..: .::: :.::. NP_001 SIQAQKN-DVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCV 120 130 140 150 160 170 180 190 200 210 220 pF1KE6 LVKMNRIIGLKPEGVPRID--CVSKN----EDIPNVAVYPHNGMIDLKYFPYYGKKLHVG ..::::.:.. . .. :..: :.. : ...: :: ::: ::::::::.::. NP_001 FIKMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVMFPANGNIDLMYFPYYGKKFHVN 180 190 200 210 220 230 230 240 250 260 270 pF1KE6 YLQPLVAVQ-VSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA : ::::::. .. .:: ::.:::.:. .::. ..:.:::: ::: ::. NP_001 YTQPLVAVKFLNVTPNV---EVNVECRIN-AANIATDDERDKFAGRVAFKLRINKT 240 250 260 270 280 290 >>NP_000696 (OMIM: 137217) potassium-transporting ATPase (291 aa) initn: 580 init1: 237 opt: 457 Z-score: 562.0 bits: 111.9 E(85289): 1.4e-24 Smith-Waterman score: 632; 35.4% identity (67.0% similar) in 285 aa overlap (5-275:6-287) 10 20 30 40 50 pF1KE6 MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMW :::. .: . :.. . .:: ::..:::: . : : :.:..:: ...::.. .. NP_000 MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 VMLQTLNDEVPKYRDQIPSPGLMVFPKPV--TALEYTFSRSDPTSYAGYIEDLKKFLKPY :..::.. .: :.::. :::. . : .:: ... :: ..: . :. :: : NP_000 VLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE6 TLEEQKNLTVCPDGALFEQ---KGPVYV--ACQFPISLLQACSGMNDPDFGYSQGNPCIL . :.. : . : : ..: .. .:.: ..:: :::. ::.::. .:.::.. NP_000 SPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFI 130 140 150 160 170 180 180 190 200 210 220 pF1KE6 VKMNRIIGLKPEG--VPRIDC--VSKNEDI--P-NVAVYPHNGMIDLKYFPYYGKKLHVG .:::::. . : . .::.:: ... ... : .: :: :: ..:.:::::::: . NP_000 IKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPH 190 200 210 220 230 240 230 240 250 260 270 pF1KE6 YLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA : .::::... : :. ::.. ::. . .. .. .: . :.: ::. NP_000 YSNPLVAAKLLNIPRNA--EVAIVCKV-MAEHVTFNNPHDPYEGKVEFKLKIEK 250 260 270 280 290 >>NP_001290192 (OMIM: 182331) sodium/potassium-transport (208 aa) initn: 468 init1: 153 opt: 419 Z-score: 517.8 bits: 103.2 E(85289): 4.2e-22 Smith-Waterman score: 502; 42.6% identity (67.5% similar) in 209 aa overlap (82-275:1-203) 60 70 80 90 100 110 pF1KE6 ALFSFTMWVMLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLK :. :: . :. . :: :. ... :. NP_001 MIRPK-TENLDVIVNVSDTESWDQHVQKLN 10 20 120 130 140 150 160 pF1KE6 KFLKPY--TLEEQKNLTVCPDGALFEQ--KGPVYV---ACQFPISLLQACSGMNDPD-FG :::.:: ... ::: :: : .:: .: . :::: . : :::..: .: NP_001 KFLEPYNDSIQAQKN-DVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYG 30 40 50 60 70 80 170 180 190 200 210 pF1KE6 YSQGNPCILVKMNRIIGLKPEGVPRID--CVSKN----EDIPNVAVYPHNGMIDLKYFPY :: :.::...::::.:.. . .. :..: :.. : ...: :: ::: :::: NP_001 YSTGQPCVFIKMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVMFPANGNIDLMYFPY 90 100 110 120 130 140 220 230 240 250 260 270 pF1KE6 YGKKLHVGYLQPLVAVQ-VSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKIT ::::.::.: ::::::. .. .:: ::.:::.:. .::. ..:.:::: ::: ::. NP_001 YGKKFHVNYTQPLVAVKFLNVTPNV---EVNVECRIN-AANIATDDERDKFAGRVAFKLR 150 160 170 180 190 200 pF1KE6 ARA NP_001 INKT >>NP_001668 (OMIM: 145500,182330) sodium/potassium-trans (303 aa) initn: 580 init1: 241 opt: 317 Z-score: 391.3 bits: 80.4 E(85289): 4.7e-15 Smith-Waterman score: 603; 36.6% identity (60.4% similar) in 298 aa overlap (16-279:12-303) 10 20 30 40 50 60 pF1KE6 MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWV :: ::.: ::::::. :: :::::..::: ::..: :. : NP_001 MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQV 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 MLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLE :: :... : :.:.. ::: .:. . : .: .:: :: .:. .. .::. : NP_001 MLLTISEFKPTYQDRVAPPGLTQIPQ-IQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDS 60 70 80 90 100 110 130 140 150 160 pF1KE6 EQKNLTV---CPD--------GALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNP :.. . : : : . ...: : :.: . : :::.:: .::..:.: NP_001 AQRDDMIFEDCGDVPSEPKERGDFNHERGERKV-CRFKLEWLGNCSGLNDETYGYKEGKP 120 130 140 150 160 170 170 180 190 200 pF1KE6 CILVKMNRIIGLKP--------EGVPR---------IDCVSK-NEDIPNVAVYPHNGM-- ::..:.::..:.:: : : ..:..: .:: .:. . :. NP_001 CIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGN 180 190 200 210 220 230 210 220 230 240 250 260 pF1KE6 ---IDLKYFPYYGKKLHVGYLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDK . :.:.::::: :. :::::.::: :. . :. .::: : :. . ...:. NP_001 SPGFPLQYYPYYGKLLQPKYLQPLLAVQ--FTNLTMDTEIRIECKAYGE-NI-GYSEKDR 240 250 260 270 280 290 270 pF1KE6 FLGRVMFKITARA : :: :: ... NP_001 FQGRFDVKIEVKS 300 279 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:47:08 2016 done: Tue Nov 8 11:47:09 2016 Total Scan time: 5.650 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]