FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4076, 402 aa 1>>>pF1KE4076 402 - 402 aa - 402 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.8680+/-0.000454; mu= -19.8663+/- 0.028 mean_var=628.9751+/-130.607, 0's: 0 Z-trim(125.6): 14 B-trim: 1703 in 1/61 Lambda= 0.051140 statistics sampled from 49785 (49805) to 49785 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.834), E-opt: 0.2 (0.584), width: 16 Scan time: 10.920 The best scores are: opt bits E(85289) NP_001096032 (OMIM: 613338) E3 ubiquitin-protein l ( 402) 2869 225.9 1.4e-58 NP_612405 (OMIM: 613336) E3 ubiquitin-protein liga ( 346) 1034 90.5 6.9e-18 NP_065865 (OMIM: 608208) E3 ubiquitin-protein liga ( 410) 975 86.2 1.6e-16 >>NP_001096032 (OMIM: 613338) E3 ubiquitin-protein ligas (402 aa) initn: 2869 init1: 2869 opt: 2869 Z-score: 1172.9 bits: 225.9 E(85289): 1.4e-58 Smith-Waterman score: 2869; 100.0% identity (100.0% similar) in 402 aa overlap (1-402:1-402) 10 20 30 40 50 60 pF1KE4 MSFEGGHGGSRCRGAESGDAEPPPQPPPPPPPTPPPGEPAPVPAAPRYLPPLPASPETPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSFEGGHGGSRCRGAESGDAEPPPQPPPPPPPTPPPGEPAPVPAAPRYLPPLPASPETPE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RAAGPSEPLGEVAPRCRGADELPPPPLPLQPAGQEVAAAGDSGEGPRRLPEAAAAKGGPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAAGPSEPLGEVAPRCRGADELPPPPLPLQPAGQEVAAAGDSGEGPRRLPEAAAAKGGPG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ESEAGAGGERERRGAGDQPETRSVCSSRSSSSGGGDQRAGHQHQHHQPICKICFQGAEQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESEAGAGGERERRGAGDQPETRSVCSSRSSSSGGGDQRAGHQHQHHQPICKICFQGAEQG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ELLNPCRCDGSVRYTHQLCLLKWISERGSWTCELCCYRYHVIAIKMKQPCQWQSISITLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELLNPCRCDGSVRYTHQLCLLKWISERGSWTCELCCYRYHVIAIKMKQPCQWQSISITLV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 EKVQMIAVILGSLFLIASVTWLLWSAFSPYAVWQRKDILFQICYGMYGFMDLVCIGLIVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKVQMIAVILGSLFLIASVTWLLWSAFSPYAVWQRKDILFQICYGMYGFMDLVCIGLIVH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 EGAAVYRVFKRWRAVNLHWDVLNYDKATDIEESSRGESSTSRTLWLPLTALRNRNLVHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGAAVYRVFKRWRAVNLHWDVLNYDKATDIEESSRGESSTSRTLWLPLTALRNRNLVHPT 310 320 330 340 350 360 370 380 390 400 pF1KE4 QLTSPRFQCGYVLLHLFNRMRPHEDLSEDNSSGEVVMRVTSV :::::::::::::::::::::::::::::::::::::::::: NP_001 QLTSPRFQCGYVLLHLFNRMRPHEDLSEDNSSGEVVMRVTSV 370 380 390 400 >>NP_612405 (OMIM: 613336) E3 ubiquitin-protein ligase M (346 aa) initn: 1103 init1: 923 opt: 1034 Z-score: 442.1 bits: 90.5 E(85289): 6.9e-18 Smith-Waterman score: 1037; 48.0% identity (69.0% similar) in 329 aa overlap (102-402:19-346) 80 90 100 110 120 130 pF1KE4 VAPRCRGADELPPPPLPLQPAGQEVAAAGDSGEG-PRRLPEAAAAKGGPGESEAGAGGER .: : :: :. ...:: : . : .: NP_612 MLKSRLRMFLNELKLLVLTGGGRPRAEPQPRGGRGG-GCGWAPFAGCS 10 20 30 40 140 150 160 pF1KE4 ERRGAGDQPETRSVCSSRSSSSGGGDQRAGHQHQHHQPI--------------------- : : ::. : . . .: . ::: :. NP_612 TRDGDGDEEEYYGSEPRARGLAGDKEPRAGPLPPPAPPLPPPGALDALSLSSSLDSGLRT 50 60 70 80 90 100 170 180 190 200 210 220 pF1KE4 --CKICFQGAEQGELLNPCRCDGSVRYTHQLCLLKWISERGSWTCELCCYRYHVIAIKMK :.::::: ::::::.::::::::: ::: ::..::::::::.:::: ..:.:.::. : NP_612 PQCRICFQGPEQGELLSPCRCDGSVRCTHQPCLIRWISERGSWSCELCYFKYQVLAISTK 110 120 130 140 150 160 230 240 250 260 270 280 pF1KE4 QPCQWQSISITLVEKVQMIAVILGSLFLIASVTWLLWSAFSPYAVWQRKDILFQICYGMY .: :::.::.:..::::. :..::::::.::..::.::..:: : :::.:.::::::::: NP_612 NPLQWQAISLTVIEKVQIAAIVLGSLFLVASISWLIWSSLSPSAKWQRQDLLFQICYGMY 170 180 190 200 210 220 290 300 310 320 330 340 pF1KE4 GFMDLVCIGLIVHEGAAVYRVFKRWRAVNLHWDVLNYDKATDIEES----SRGESSTSRT ::::.::::::.:::..:::.::::.::: .: ::::::. :: . . :.:. . NP_612 GFMDVVCIGLIIHEGSSVYRIFKRWQAVNQQWKVLNYDKTKDIGGDAGGGTAGKSGPRNS 230 240 250 260 270 280 350 360 370 380 390 400 pF1KE4 LWLPLTALRNRNLVHPTQLTSPRFQCGYVLLHLFNRMRPHEDLSEDNSSGEVVMRVTSV : .. .: . . : .:::..:::....:: . : ..:. :::::::.: NP_612 RTGPTSGATSRPPAAQRMRTLLPQRCGYTILHLLGQLRPPDARSSSHSGREVVMRVTTV 290 300 310 320 330 340 >>NP_065865 (OMIM: 608208) E3 ubiquitin-protein ligase M (410 aa) initn: 1124 init1: 958 opt: 975 Z-score: 417.6 bits: 86.2 E(85289): 1.6e-16 Smith-Waterman score: 1122; 47.2% identity (66.8% similar) in 392 aa overlap (28-402:57-410) 10 20 30 40 50 pF1KE4 MSFEGGHGGSRCRGAESGDAEPPPQPPPPPPPTPPPGEPAPVP--AAPRYLPPLPAS :: : : :.: : : :: :: : :. NP_065 PAPQMLRHQGLLKCRCRMLFNDLKVFLLRRPPQAPLPMHGDPQP-PGLAANNTLPALGAG 30 40 50 60 70 80 60 70 80 90 100 110 pF1KE4 PETPERAAGPSEPLGEVAPRCRGADELPPPPLPLQPAGQEVAAAGDSGEGPRRLPEAAAA . : :: : .:. : .:::: :: :.. : :. :: : :. NP_065 GWAGWR--GPREVVGREPP------PVPPPP-PLPPSSVE-----DDWGGPATEPPASLL 90 100 110 120 130 120 130 140 150 160 170 pF1KE4 KGGPGESEAGAGGERERRGAGDQPETRSVCSSRSSSSGGGDQRAGHQHQHHQPICKICFQ ... ... : .: . :. : .:: . :.:.:::: NP_065 SSASSDDFCKEKTE-DRYSLGS-----------SLDSG-----------MRTPLCRICFQ 140 150 160 180 190 200 210 220 230 pF1KE4 GAEQGELLNPCRCDGSVRYTHQLCLLKWISERGSWTCELCCYRYHVIAIKMKQPCQWQSI : ::::::.::::::::. ::: ::.::::::: :.:::: :.::::::. :.: :::.: NP_065 GPEQGELLSPCRCDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAISTKNPLQWQAI 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE4 SITLVEKVQMIAVILGSLFLIASVTWLLWSAFSPYAVWQRKDILFQICYGMYGFMDLVCI :.:..::::. :.::::::::::..::.::.::: : :::.:.:::::::::::::.::: NP_065 SLTVIEKVQVAAAILGSLFLIASISWLIWSTFSPSARWQRQDLLFQICYGMYGFMDVVCI 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE4 GLIVHEGAAVYRVFKRWRAVNLHWDVLNYDKATDIEESSRG-----ESSTSRTLWLPLTA :::.::: .:::.::::.::: .: ::::::. :.:... : ..:.: .: . NP_065 GLIIHEGPSVYRIFKRWQAVNQQWKVLNYDKTKDLEDQKAGGRTNPRTSSSTQANIPSSE 290 300 310 320 330 340 360 370 380 390 400 pF1KE4 LRNRNLVHPTQL--------TSP--RFQCGYVLLHLFNRMRPHEDLSEDNSSGEVVMRVT .. . : : ..: . .:.:..::.....::::. : .:: :.::::: NP_065 EETAGTPAPEQGPAQAAGHPSGPLSHHHCAYTILHILSHLRPHEQRSPPGSSRELVMRVT 350 360 370 380 390 400 pF1KE4 SV .: NP_065 TV 410 402 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:13:06 2016 done: Sun Nov 6 04:13:07 2016 Total Scan time: 10.920 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]