FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6387, 328 aa 1>>>pF1KE6387 328 - 328 aa - 328 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8285+/-0.000363; mu= 18.2422+/- 0.022 mean_var=64.7401+/-13.109, 0's: 0 Z-trim(114.1): 308 B-trim: 0 in 0/51 Lambda= 0.159400 statistics sampled from 23476 (23796) to 23476 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.648), E-opt: 0.2 (0.279), width: 16 Scan time: 5.330 The best scores are: opt bits E(85289) NP_659205 (OMIM: 608159) testisin isoform 2 prepro ( 312) 700 169.7 7.1e-42 NP_006790 (OMIM: 608159) testisin isoform 1 prepro ( 314) 698 169.3 9.8e-42 NP_114154 (OMIM: 608018) serine protease 27 isofor ( 290) 694 168.3 1.7e-41 NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 689 167.2 4.4e-41 NP_690851 (OMIM: 613797) serine protease 33 precur ( 280) 676 164.2 3e-40 XP_011520753 (OMIM: 613797) PREDICTED: serine prot ( 280) 676 164.2 3e-40 XP_011520754 (OMIM: 613797) PREDICTED: serine prot ( 280) 676 164.2 3e-40 NP_071402 (OMIM: 609343) brain-specific serine pro ( 317) 651 158.5 1.8e-38 XP_005255530 (OMIM: 609343) PREDICTED: brain-speci ( 317) 651 158.5 1.8e-38 NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 645 157.1 4.6e-38 XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 641 156.2 9.3e-38 XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 641 156.2 9.3e-38 XP_016878460 (OMIM: 610560) PREDICTED: polyserase- ( 621) 624 152.5 2.2e-36 XP_016878459 (OMIM: 610560) PREDICTED: polyserase- ( 634) 624 152.5 2.2e-36 XP_016878458 (OMIM: 610560) PREDICTED: polyserase- ( 637) 624 152.5 2.2e-36 NP_001245220 (OMIM: 610560) polyserase-2 isoform 3 ( 752) 624 152.5 2.5e-36 XP_016878457 (OMIM: 610560) PREDICTED: polyserase- ( 761) 624 152.5 2.6e-36 NP_001245219 (OMIM: 610560) polyserase-2 isoform 2 ( 850) 624 152.6 2.8e-36 NP_775773 (OMIM: 610560) polyserase-2 isoform 1 pr ( 855) 624 152.6 2.8e-36 NP_077078 (OMIM: 191081) tryptase beta-2 prepropro ( 275) 614 149.9 5.8e-36 NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 609 148.8 1.3e-35 NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 599 146.5 7.2e-35 NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 599 146.6 9.3e-35 XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 598 146.3 9.6e-35 NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 601 147.3 1e-34 NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 601 147.3 1.1e-34 XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 598 146.4 1.1e-34 NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 598 146.4 1.2e-34 XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 598 146.4 1.2e-34 NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 598 146.4 1.2e-34 NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 592 145.1 3.2e-34 NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 592 145.1 3.3e-34 NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 592 145.1 3.4e-34 NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 574 140.8 4.6e-33 NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 574 140.9 4.9e-33 NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 574 140.9 5e-33 XP_016882221 (OMIM: 142440) PREDICTED: serine prot ( 393) 540 133.0 1e-30 XP_016882220 (OMIM: 142440) PREDICTED: serine prot ( 417) 540 133.0 1.1e-30 XP_006723244 (OMIM: 142440) PREDICTED: serine prot ( 417) 540 133.0 1.1e-30 XP_005258895 (OMIM: 142440) PREDICTED: serine prot ( 417) 540 133.0 1.1e-30 NP_002142 (OMIM: 142440) serine protease hepsin pr ( 417) 540 133.0 1.1e-30 NP_892028 (OMIM: 142440) serine protease hepsin pr ( 417) 540 133.0 1.1e-30 NP_254275 (OMIM: 609443) chymotrypsin-like elastas ( 269) 505 124.8 2e-28 NP_036349 (OMIM: 609272) tryptase delta precursor ( 242) 482 119.5 7.2e-27 NP_037402 (OMIM: 607950) probable threonine protea ( 385) 468 116.4 9.6e-26 NP_001305324 (OMIM: 608018) serine protease 27 iso ( 188) 464 115.3 1e-25 XP_011520991 (OMIM: 608018) PREDICTED: serine prot ( 188) 464 115.3 1e-25 XP_011535778 (OMIM: 227500,608446,613878) PREDICTE ( 364) 459 114.4 3.8e-25 NP_001254483 (OMIM: 227500,608446,613878) coagulat ( 382) 459 114.4 4e-25 XP_006720026 (OMIM: 227500,608446,613878) PREDICTE ( 412) 459 114.4 4.2e-25 >>NP_659205 (OMIM: 608159) testisin isoform 2 preproprot (312 aa) initn: 662 init1: 219 opt: 700 Z-score: 872.8 bits: 169.7 E(85289): 7.1e-42 Smith-Waterman score: 700; 41.2% identity (66.9% similar) in 284 aa overlap (19-291:33-311) 10 20 30 40 pF1KE6 MGPAGCAFTLLLLLGISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFD ::. : .::.:::.:: :::::: ::.. NP_659 ARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLW 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE6 HNFIYGGSLVSERLILTAAHCIQPTWTTFS-YTVWLGSITVGDS-----RKRVKYYVSKI . . : ::.:.: ::::::.. . : . : .:..: : ..:.::.: NP_659 DSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNI 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE6 VIHPKYQ-DTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSD . :.: .. :.::.:::. ::.:. : :::: . : .. ::::::: .::. NP_659 YLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEA 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE6 RDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSG .:::..: ::. . :..:. . ... : : .:::..:. ::.: :::: NP_659 LPSPHTLQEVQVAIINNSMCNHLF-----LKYSFRKDIFGDMVCAGNAQGGKDACFGDSG 190 200 210 220 230 230 240 250 260 270 pF1KE6 GPLSCHIDGVWIQTGVVSWGLECGK-SLPGVYTNVIYYQKWINATISRA--NNLDFS-DF :::.:. .:.: : ::::::. ::. . ::::::. .. .::. .... .. : : . NP_659 GPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWPL 240 250 260 270 280 290 280 290 300 310 320 pF1KE6 LFPIVLLSLALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR :: .: .: :: : NP_659 LFFPLLWALPLLGPV 300 310 >>NP_006790 (OMIM: 608159) testisin isoform 1 preproprot (314 aa) initn: 662 init1: 219 opt: 698 Z-score: 870.3 bits: 169.3 E(85289): 9.8e-42 Smith-Waterman score: 698; 41.1% identity (67.2% similar) in 287 aa overlap (19-291:33-313) 10 20 30 40 pF1KE6 MGPAGCAFTLLLLLGISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFD ::. : .::.:::.:: :::::: ::.. NP_006 ARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLW 10 20 30 40 50 60 50 60 70 80 90 pF1KE6 HNFIYGGSLVSERLILTAAHCIQPTWTTFS----YTVWLGSITVGDS-----RKRVKYYV . . : ::.:.: ::::::.. :.. .: . : .:..: : ..:.: NP_006 DSHVCGVSLLSHRWALTAAHCFE-TYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE6 SKIVIHPKYQ-DTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKE :.: . :.: .. :.::.:::. ::.:. : :::: . : .. ::::::: .:: NP_006 SNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKE 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE6 SSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKG . .:::..: ::. . :..:. . ... : : .:::..:. ::.: : NP_006 DEALPSPHTLQEVQVAIINNSMCNHLF-----LKYSFRKDIFGDMVCAGNAQGGKDACFG 190 200 210 220 230 220 230 240 250 260 270 pF1KE6 DSGGPLSCHIDGVWIQTGVVSWGLECGK-SLPGVYTNVIYYQKWINATISRA--NNLDFS ::::::.:. .:.: : ::::::. ::. . ::::::. .. .::. .... .. : : NP_006 DSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPS 240 250 260 270 280 290 280 290 300 310 320 pF1KE6 -DFLFPIVLLSLALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR .:: .: .: :: : NP_006 WPLLFFPLLWALPLLGPV 300 310 >>NP_114154 (OMIM: 608018) serine protease 27 isoform 1 (290 aa) initn: 643 init1: 238 opt: 694 Z-score: 865.8 bits: 168.3 E(85289): 1.7e-41 Smith-Waterman score: 694; 41.2% identity (64.6% similar) in 277 aa overlap (3-268:4-278) 10 20 30 40 50 pF1KE6 MGPAGCAFTLLLLLG------ISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFIY ::. . ::: .: ..::.: . .:.:::::. :.::::::.. . . . NP_114 MRRPAAVPLLLLLCFGSQRAKAATACGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 GGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKRVKY-YVSKIVIHPKYQDT- ::::..:. .::::::.. : : : : ::. . . .. : : .. .: :: : NP_114 GGSLIAEQWVLTAAHCFRNTSETSLYQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE6 -TADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQE .:::::..: . : ::. :::.:::. . . :::::::. .: . ::. NP_114 SSADVALVELEAPVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQK 130 140 150 160 170 180 180 190 200 210 220 pF1KE6 AEVPIIDRQACEQLYNPIGIFLPALEP-VIKEDKICAGDTQNMKDSCKGDSGGPLSCHID ::::: :. ::. : . .: .::.: .::: .. ::.::::::::: : . NP_114 LAVPIIDTPKCNLLYSKDTEF--GYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVG 190 200 210 220 230 230 240 250 260 270 280 pF1KE6 GVWIQTGVVSWGLECGK-SLPGVYTNVIYYQKWINATISRANNLDFSDFLFPIVLLSLAL :.:.::.::: :.. . :::: : ...::. : . NP_114 QSWLQAGVISWGEGCARQNRPGVYIRVTAHHNWIHRIIPKLQFQPARLGGQK 240 250 260 270 280 290 290 300 310 320 pF1KE6 LCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR >>NP_002764 (OMIM: 600823) prostasin preproprotein [Homo (343 aa) initn: 671 init1: 235 opt: 689 Z-score: 858.6 bits: 167.2 E(85289): 4.4e-41 Smith-Waterman score: 690; 40.4% identity (65.6% similar) in 285 aa overlap (1-267:7-286) 10 20 30 40 pF1KE6 MGPAGC-AFTLLLLLGI-----------SVCG-QPVYSSRVVGGQDAAAGRWPW .::. : ..:: ::. . :: : ..:..::..:.::.::: NP_002 MAQKGVLGPGQLGAVAILLYLGLLRSGTGAEGAEAPCGVAP--QARITGGSSAVAGQWPW 10 20 30 40 50 50 60 70 80 90 100 pF1KE6 QVSLHFDHNFIYGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKRVKYYVSK :::. .. . :::::::. .:.::::. .: : ::. . . . .: . : NP_002 QVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLK 60 70 80 90 100 110 110 120 130 140 150 pF1KE6 -IVIHPKY--QDTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKE :. ::.: . . .:.:::.:: .::. : :::::... .. : :::::.: NP_002 DIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAP 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE6 SSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEP-VIKEDKICAGDTQNMKDSCK : . . ::. :::.:.:..:. ::: : :: ..:: .::: ... ::.:. NP_002 SVSLLTPKPLQQLEVPLISRETCNCLYN---IDAKPEEPHFVQEDMVCAGYVEGGKDACQ 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE6 GDSGGPLSCHIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQKWINATISRANNLDFSD ::::::::: ..:.: ::.:::: :: .. ::::: . : .::.. .. NP_002 GDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRVVPQ 240 250 260 270 280 290 280 290 300 310 320 pF1KE6 FLFPIVLLSLALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR NP_002 TQESQPDSNLCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH 300 310 320 330 340 >>NP_690851 (OMIM: 613797) serine protease 33 precursor (280 aa) initn: 565 init1: 244 opt: 676 Z-score: 843.6 bits: 164.2 E(85289): 3e-40 Smith-Waterman score: 677; 38.7% identity (63.8% similar) in 282 aa overlap (1-267:1-279) 10 20 30 40 50 pF1KE6 MGPAGCAFTLLLL-LGIS--------VCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNF : ..: .:::: :: . .:::: .:::.:::.:. :.::::.:.. NP_690 MRGVSCLQVLLLLVLGAAGTQGRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 IYGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKR-VKYYVSKIVIHPKYQD . ::::.. . .::::::. : : ::.. .:.. : .. : .... : :.. NP_690 VCGGSLIAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSE 70 80 90 100 110 120 120 130 140 150 160 pF1KE6 TTA--DVALLKLSSQVTFTSAILPICLPSVTKQLAIPPF--CWVTGWGKVKESSDRDYHS : :.:::.: : ... . :.::: . :: : :::::... . NP_690 DGARGDLALLQLRRPVPLSARVQPVCLPVPGAR--PPPGTPCRVTGWGSLRPGVPLPEWR 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 ALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSC :: ..::..: ..:. ::. .: .: : .. ..::: :. ::.:.:::::::.: NP_690 PLQGVRVPLLDSRTCDGLYH-VGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTC 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE6 HIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQKWINATISRANNLDFSDFLFPIVLLS .: :. .:::::: :. . :::::.: :. ::.: .: NP_690 LQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF 240 250 260 270 280 290 300 310 320 pF1KE6 LALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR >>XP_011520753 (OMIM: 613797) PREDICTED: serine protease (280 aa) initn: 565 init1: 244 opt: 676 Z-score: 843.6 bits: 164.2 E(85289): 3e-40 Smith-Waterman score: 677; 38.7% identity (63.8% similar) in 282 aa overlap (1-267:1-279) 10 20 30 40 50 pF1KE6 MGPAGCAFTLLLL-LGIS--------VCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNF : ..: .:::: :: . .:::: .:::.:::.:. :.::::.:.. XP_011 MRGVSCLQVLLLLVLGAAGTQGRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 IYGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKR-VKYYVSKIVIHPKYQD . ::::.. . .::::::. : : ::.. .:.. : .. : .... : :.. XP_011 VCGGSLIAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSE 70 80 90 100 110 120 120 130 140 150 160 pF1KE6 TTA--DVALLKLSSQVTFTSAILPICLPSVTKQLAIPPF--CWVTGWGKVKESSDRDYHS : :.:::.: : ... . :.::: . :: : :::::... . XP_011 DGARGDLALLQLRRPVPLSARVQPVCLPVPGAR--PPPGTPCRVTGWGSLRPGVPLPEWR 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 ALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSC :: ..::..: ..:. ::. .: .: : .. ..::: :. ::.:.:::::::.: XP_011 PLQGVRVPLLDSRTCDGLYH-VGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTC 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE6 HIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQKWINATISRANNLDFSDFLFPIVLLS .: :. .:::::: :. . :::::.: :. ::.: .: XP_011 LQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF 240 250 260 270 280 290 300 310 320 pF1KE6 LALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR >>XP_011520754 (OMIM: 613797) PREDICTED: serine protease (280 aa) initn: 565 init1: 244 opt: 676 Z-score: 843.6 bits: 164.2 E(85289): 3e-40 Smith-Waterman score: 677; 38.7% identity (63.8% similar) in 282 aa overlap (1-267:1-279) 10 20 30 40 50 pF1KE6 MGPAGCAFTLLLL-LGIS--------VCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNF : ..: .:::: :: . .:::: .:::.:::.:. :.::::.:.. XP_011 MRGVSCLQVLLLLVLGAAGTQGRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 IYGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKR-VKYYVSKIVIHPKYQD . ::::.. . .::::::. : : ::.. .:.. : .. : .... : :.. XP_011 VCGGSLIAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSE 70 80 90 100 110 120 120 130 140 150 160 pF1KE6 TTA--DVALLKLSSQVTFTSAILPICLPSVTKQLAIPPF--CWVTGWGKVKESSDRDYHS : :.:::.: : ... . :.::: . :: : :::::... . XP_011 DGARGDLALLQLRRPVPLSARVQPVCLPVPGAR--PPPGTPCRVTGWGSLRPGVPLPEWR 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 ALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSC :: ..::..: ..:. ::. .: .: : .. ..::: :. ::.:.:::::::.: XP_011 PLQGVRVPLLDSRTCDGLYH-VGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTC 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE6 HIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQKWINATISRANNLDFSDFLFPIVLLS .: :. .:::::: :. . :::::.: :. ::.: .: XP_011 LQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF 240 250 260 270 280 290 300 310 320 pF1KE6 LALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR >>NP_071402 (OMIM: 609343) brain-specific serine proteas (317 aa) initn: 252 init1: 252 opt: 651 Z-score: 811.8 bits: 158.5 E(85289): 1.8e-38 Smith-Waterman score: 653; 35.1% identity (65.6% similar) in 282 aa overlap (5-266:13-289) 10 20 30 pF1KE6 MGPAGC--AFTLLLLLGISV------------CGQPVYSSRVVGGQDAAAGR :: .:: ::::. .. ::.: .:::::.:.. .. NP_071 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE6 WPWQVSLHFDHNFIYGGSLVSERLILTAAHCIQPTWTT-FSYTVWLGSITVGDSRKRV-K ::: ::.. . . .:::.. : ..:::::.. . . . ..: ::. .:. .: : NP_071 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE6 YYVSKIVIHPKY---QDTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGW :. . :: : . . ::.::..: .. :. .::::::... .: ::..:: NP_071 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE6 GKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMK :..... . ..::. .::::: ..: .:: . : . : :: .::: .. . NP_071 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLY-----WRGAGQGPITEDMLCAGYLEGER 190 200 210 220 230 220 230 240 250 260 270 pF1KE6 DSCKGDSGGPLSCHIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQKWINATISRANNL :.: ::::::: :..::.:. .:..::: :. .. :::: .. ...:.. . NP_071 DACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLR 240 250 260 270 280 290 280 290 300 310 320 pF1KE6 DFSDFLFPIVLLSLALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR NP_071 GRAQGGGALRAPSQGSGAAARS 300 310 >>XP_005255530 (OMIM: 609343) PREDICTED: brain-specific (317 aa) initn: 252 init1: 252 opt: 651 Z-score: 811.8 bits: 158.5 E(85289): 1.8e-38 Smith-Waterman score: 653; 35.1% identity (65.6% similar) in 282 aa overlap (5-266:13-289) 10 20 30 pF1KE6 MGPAGC--AFTLLLLLGISV------------CGQPVYSSRVVGGQDAAAGR :: .:: ::::. .. ::.: .:::::.:.. .. XP_005 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE6 WPWQVSLHFDHNFIYGGSLVSERLILTAAHCIQPTWTT-FSYTVWLGSITVGDSRKRV-K ::: ::.. . . .:::.. : ..:::::.. . . . ..: ::. .:. .: : XP_005 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE6 YYVSKIVIHPKY---QDTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGW :. . :: : . . ::.::..: .. :. .::::::... .: ::..:: XP_005 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE6 GKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMK :..... . ..::. .::::: ..: .:: . : . : :: .::: .. . XP_005 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLY-----WRGAGQGPITEDMLCAGYLEGER 190 200 210 220 230 220 230 240 250 260 270 pF1KE6 DSCKGDSGGPLSCHIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQKWINATISRANNL :.: ::::::: :..::.:. .:..::: :. .. :::: .. ...:.. . XP_005 DACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLR 240 250 260 270 280 290 280 290 300 310 320 pF1KE6 DFSDFLFPIVLLSLALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR XP_005 GRAQGGGALRAPSQGSGAAARS 300 310 >>NP_036599 (OMIM: 609341) tryptase gamma preproprotein (321 aa) initn: 550 init1: 199 opt: 645 Z-score: 804.3 bits: 157.1 E(85289): 4.6e-38 Smith-Waterman score: 659; 36.6% identity (65.0% similar) in 314 aa overlap (1-295:1-302) 10 20 30 40 50 pF1KE6 MGPAGCAFTLLLLL-GISV------CGQPVYSS---RVVGGQDAAAGRWPWQVSLHFDHN :. ..:.. ::: . :.:. ::.: :. :.:::. : :: ::::.::.. . NP_036 MALGACGLLLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRV 10 20 30 40 50 60 60 70 80 90 100 pF1KE6 FIYGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIH--PKY . ::::.: . .::::::.. . .. .: : :: . . : . : .:..: :. NP_036 HVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFST--VRQIILHSSPSG 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 QD-TTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSA : :..:.::..:: ::..: :::.::: .. .. ::::::: ..:. . NP_036 QPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYS 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 LQEAEVPIIDRQACEQLY-NPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSC :.:..: ..: ..:.. : .: : ... : .:: .. :.:. :::::: : NP_036 LREVKVSVVDTETCRRDYPGPGG-------SILQPDMLCA---RGPGDACQDDSGGPLVC 180 190 200 210 220 230 240 250 260 270 280 pF1KE6 HIDGVWIQTGVVSWGLECGK-SLPGVYTNVIYYQKWINATISRANNLDFSDFLFPIV--- ...:.:.:.:.:::: ::. . ::::: : : .:: :. ... . . .:.. NP_036 QVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGYPRLPLLAGF 230 240 250 260 270 280 290 300 310 320 pF1KE6 -LLSLALLCPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR : .: :: ::.. NP_036 FLPGLFLLLVSCVLLAKCLLHPSADGTPFPAPD 290 300 310 320 328 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 12:49:00 2016 done: Tue Nov 8 12:49:01 2016 Total Scan time: 5.330 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]