FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3113, 286 aa 1>>>pF1KE3113 286 - 286 aa - 286 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.6882+/-0.000414; mu= 10.7139+/- 0.026 mean_var=176.8829+/-36.224, 0's: 0 Z-trim(117.7): 24 B-trim: 712 in 1/54 Lambda= 0.096434 statistics sampled from 29840 (29864) to 29840 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.35), width: 16 Scan time: 6.620 The best scores are: opt bits E(85289) NP_001099043 (OMIM: 609112) F-box/SPRY domain-cont ( 286) 1974 286.5 3.8e-77 NP_001139788 (OMIM: 611658) SPRY domain-containing ( 263) 540 87.0 4.2e-17 NP_001306599 (OMIM: 611658) SPRY domain-containing ( 263) 540 87.0 4.2e-17 NP_116030 (OMIM: 611658) SPRY domain-containing SO ( 263) 540 87.0 4.2e-17 XP_016862998 (OMIM: 611660) PREDICTED: SPRY domain ( 233) 516 83.6 3.9e-16 NP_543138 (OMIM: 611660) SPRY domain-containing SO ( 273) 516 83.7 4.3e-16 NP_079382 (OMIM: 611657) SPRY domain-containing SO ( 273) 490 80.1 5.3e-15 >>NP_001099043 (OMIM: 609112) F-box/SPRY domain-containi (286 aa) initn: 1974 init1: 1974 opt: 1974 Z-score: 1505.9 bits: 286.5 E(85289): 3.8e-77 Smith-Waterman score: 1974; 100.0% identity (100.0% similar) in 286 aa overlap (1-286:1-286) 10 20 30 40 50 60 pF1KE3 MAAPAPGAGAASGGAGCSGGGAGAGAGSGSGAAGAGGRLPSRVLELVFSYLELSELRSCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAPAPGAGAASGGAGCSGGGAGAGAGSGSGAAGAGGRLPSRVLELVFSYLELSELRSCA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LVCKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVCKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 RNVYIKKNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEGPLGTVAVIGIATKRAPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNVYIKKNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEGPLGTVAVIGIATKRAPM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 QCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGSFPQCNNAPKYQIGERIRVILDMEDKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGSFPQCNNAPKYQIGERIRVILDMEDKT 190 200 210 220 230 240 250 260 270 280 pF1KE3 LAFERGYEFLGVAFRGLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG :::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAFERGYEFLGVAFRGLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG 250 260 270 280 >>NP_001139788 (OMIM: 611658) SPRY domain-containing SOC (263 aa) initn: 515 init1: 209 opt: 540 Z-score: 428.1 bits: 87.0 E(85289): 4.2e-17 Smith-Waterman score: 540; 46.3% identity (75.1% similar) in 177 aa overlap (111-282:45-219) 90 100 110 120 130 140 pF1KE3 SLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQS .:... .:::.:. .:..:. ..: :.::: NP_001 TPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQS 20 30 40 50 60 70 150 160 170 180 190 pF1KE3 TDGARTKIGFSEGRHAWEVWWEGPL---GTVAVIGIATKRAPMQCQGYVALLGSDDQSWG ::::: : :.:.: ::::. : :: :: ::.:.:: ::.: . :.:::::...::: NP_001 TDGARGKRGYSRGLHAWEISW--PLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWG 80 90 100 110 120 130 200 210 220 230 240 250 pF1KE3 WNLVDNNLLHNGEVNGS--FPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFR :.. ..: :... :. .: ... . .. ::. :.::::. ::.. : .:: ::: NP_001 WDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFR 140 150 160 170 180 190 260 270 280 pF1KE3 GLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG :: ::::::::.:. .: . :::. NP_001 GLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPL 200 210 220 230 240 250 >>NP_001306599 (OMIM: 611658) SPRY domain-containing SOC (263 aa) initn: 515 init1: 209 opt: 540 Z-score: 428.1 bits: 87.0 E(85289): 4.2e-17 Smith-Waterman score: 540; 46.3% identity (75.1% similar) in 177 aa overlap (111-282:45-219) 90 100 110 120 130 140 pF1KE3 SLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQS .:... .:::.:. .:..:. ..: :.::: NP_001 TPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQS 20 30 40 50 60 70 150 160 170 180 190 pF1KE3 TDGARTKIGFSEGRHAWEVWWEGPL---GTVAVIGIATKRAPMQCQGYVALLGSDDQSWG ::::: : :.:.: ::::. : :: :: ::.:.:: ::.: . :.:::::...::: NP_001 TDGARGKRGYSRGLHAWEISW--PLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWG 80 90 100 110 120 130 200 210 220 230 240 250 pF1KE3 WNLVDNNLLHNGEVNGS--FPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFR :.. ..: :... :. .: ... . .. ::. :.::::. ::.. : .:: ::: NP_001 WDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFR 140 150 160 170 180 190 260 270 280 pF1KE3 GLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG :: ::::::::.:. .: . :::. NP_001 GLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPL 200 210 220 230 240 250 >>NP_116030 (OMIM: 611658) SPRY domain-containing SOCS b (263 aa) initn: 515 init1: 209 opt: 540 Z-score: 428.1 bits: 87.0 E(85289): 4.2e-17 Smith-Waterman score: 540; 46.3% identity (75.1% similar) in 177 aa overlap (111-282:45-219) 90 100 110 120 130 140 pF1KE3 SLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQS .:... .:::.:. .:..:. ..: :.::: NP_116 TPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQS 20 30 40 50 60 70 150 160 170 180 190 pF1KE3 TDGARTKIGFSEGRHAWEVWWEGPL---GTVAVIGIATKRAPMQCQGYVALLGSDDQSWG ::::: : :.:.: ::::. : :: :: ::.:.:: ::.: . :.:::::...::: NP_116 TDGARGKRGYSRGLHAWEISW--PLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWG 80 90 100 110 120 130 200 210 220 230 240 250 pF1KE3 WNLVDNNLLHNGEVNGS--FPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFR :.. ..: :... :. .: ... . .. ::. :.::::. ::.. : .:: ::: NP_116 WDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFR 140 150 160 170 180 190 260 270 280 pF1KE3 GLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG :: ::::::::.:. .: . :::. NP_116 GLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPL 200 210 220 230 240 250 >>XP_016862998 (OMIM: 611660) PREDICTED: SPRY domain-con (233 aa) initn: 472 init1: 164 opt: 516 Z-score: 410.7 bits: 83.6 E(85289): 3.9e-16 Smith-Waterman score: 516; 42.5% identity (70.5% similar) in 193 aa overlap (93-280:36-227) 70 80 90 100 110 120 pF1KE3 CKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRN : : : ..:. .. ..::.. .: : : XP_016 SGSLKSVEVREPALRPAKRELRGAEPGRPARLDQLLDMPAAGLAVQ-LRHAWNPEDRSLN 10 20 30 40 50 60 130 140 150 160 170 180 pF1KE3 VYIKKNG-FTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEG-PLGTVAVIGIATKRAPM :..: . .:.::.:.:::::: : :.: ..: :::.. : . :: ::.:.:: :::. XP_016 VFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATARAPL 70 80 90 100 110 120 190 200 210 220 230 pF1KE3 QCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNG--SFPQCNNAPK-YQIGERIRVILDME . ::.::.::: .::::.: . : :.:. . ..: . . . . . . :.:::. XP_016 HSVGYTALVGSDAESWGWDLGRSRLYHDGKNQPGVAYPAFLGPDEAFALPDSLLVVLDMD 130 140 150 160 170 180 240 250 260 270 280 pF1KE3 DKTLAFERGYEFLGVAFRGLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG . ::.: ..:::::::: :::.::::.:. :::. :. XP_016 EGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDQN 190 200 210 220 230 >>NP_543138 (OMIM: 611660) SPRY domain-containing SOCS b (273 aa) initn: 460 init1: 164 opt: 516 Z-score: 409.9 bits: 83.7 E(85289): 4.3e-16 Smith-Waterman score: 516; 42.5% identity (70.5% similar) in 193 aa overlap (93-280:36-227) 70 80 90 100 110 120 pF1KE3 CKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRN : : : ..:. .. ..::.. .: : : NP_543 SGSLKSVEVREPALRPAKRELRGAEPGRPARLDQLLDMPAAGLAVQ-LRHAWNPEDRSLN 10 20 30 40 50 60 130 140 150 160 170 180 pF1KE3 VYIKKNG-FTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEG-PLGTVAVIGIATKRAPM :..: . .:.::.:.:::::: : :.: ..: :::.. : . :: ::.:.:: :::. NP_543 VFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATARAPL 70 80 90 100 110 120 190 200 210 220 230 pF1KE3 QCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNG--SFPQCNNAPK-YQIGERIRVILDME . ::.::.::: .::::.: . : :.:. . ..: . . . . . . :.:::. NP_543 HSVGYTALVGSDAESWGWDLGRSRLYHDGKNQPGVAYPAFLGPDEAFALPDSLLVVLDMD 130 140 150 160 170 180 240 250 260 270 280 pF1KE3 DKTLAFERGYEFLGVAFRGLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG . ::.: ..:::::::: :::.::::.:. :::. :. NP_543 EGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRRS 190 200 210 220 230 240 NP_543 IRSALGRQRLQDISSLPLPQSLKNYLQYQ 250 260 270 >>NP_079382 (OMIM: 611657) SPRY domain-containing SOCS b (273 aa) initn: 441 init1: 162 opt: 490 Z-score: 390.3 bits: 80.1 E(85289): 5.3e-15 Smith-Waterman score: 490; 39.4% identity (69.4% similar) in 193 aa overlap (93-280:36-227) 70 80 90 100 110 120 pF1KE3 CKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRN : :.: ..: . .. . :....:: : : NP_079 TGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQ-LLHSWNNNDRSLN 10 20 30 40 50 60 130 140 150 160 170 180 pF1KE3 VYIKKNG-FTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEG-PLGTVAVIGIATKRAPM :..:.. . .::.:.:::::. : :.:...: :.:.. : :: ::.:.:: ::. NP_079 VFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPL 70 80 90 100 110 120 190 200 210 220 230 pF1KE3 QCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGS--FPQCNNAPK-YQIGERIRVILDME . ::..:.:.. .::::.: : : :.:. . : .: . . . . . . : :::. NP_079 HSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMD 130 140 150 160 170 180 240 250 260 270 280 pF1KE3 DKTLAFERGYEFLGVAFRGLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG : ::.: ...::::::: :::.::::.:. :. . :: NP_079 DGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRS 190 200 210 220 230 240 NP_079 VRLALGRERLGEIHTLPLPASLKAYLLYQ 250 260 270 286 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 10:30:07 2016 done: Sun Nov 6 10:30:08 2016 Total Scan time: 6.620 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]