FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6288, 307 aa 1>>>pF1KE6288 307 - 307 aa - 307 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4168+/-0.000308; mu= 15.7070+/- 0.019 mean_var=76.5528+/-15.682, 0's: 0 Z-trim(117.1): 17 B-trim: 1395 in 1/52 Lambda= 0.146586 statistics sampled from 28803 (28819) to 28803 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.695), E-opt: 0.2 (0.338), width: 16 Scan time: 4.720 The best scores are: opt bits E(85289) NP_945349 (OMIM: 609789) aquaporin-12A precursor [ ( 295) 1697 367.9 1.4e-101 NP_766627 (OMIM: 609914) aquaporin-11 [Homo sapien ( 271) 385 90.4 4.3e-18 XP_005273974 (OMIM: 609914) PREDICTED: aquaporin-1 ( 232) 239 59.5 7.4e-09 NP_001160 (OMIM: 603750) aquaporin-8 [Homo sapiens ( 261) 150 40.7 0.0038 XP_011544124 (OMIM: 603750) PREDICTED: aquaporin-8 ( 262) 150 40.7 0.0038 >>NP_945349 (OMIM: 609789) aquaporin-12A precursor [Homo (295 aa) initn: 1695 init1: 1695 opt: 1697 Z-score: 1944.9 bits: 367.9 E(85289): 1.4e-101 Smith-Waterman score: 1912; 95.1% identity (95.8% similar) in 307 aa overlap (1-307:1-295) 10 20 30 40 50 60 pF1KE6 MAGLNVSLSFFFATFTLCEAARRASKALLPVGAYEVFAREAVGAVQLGACFLEMRTLVEL :::::::::::::::.::::::::::::::::::::::::: ::::::: NP_945 MAGLNVSLSFFFATFALCEAARRASKALLPVGAYEVFAREA------------MRTLVEL 10 20 30 40 70 80 90 100 110 120 pF1KE6 GPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEESLPGTLLKLAAQGL :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: NP_945 GPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEQSLPGTLLKLAAQGL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE6 GMQAACTLTRLCWAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHL :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_945 GMQAACTLMRLCWAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHL 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE6 RHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_945 RHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE6 TGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSSVREPGRSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_945 TGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSSVREPGRSG 230 240 250 260 270 280 pF1KE6 VEGPHSS ::::::: NP_945 VEGPHSS 290 >>NP_766627 (OMIM: 609914) aquaporin-11 [Homo sapiens] (271 aa) initn: 360 init1: 224 opt: 385 Z-score: 445.9 bits: 90.4 E(85289): 4.3e-18 Smith-Waterman score: 385; 30.6% identity (62.0% similar) in 255 aa overlap (7-257:17-261) 10 20 30 40 50 pF1KE6 MAGLNVSLSFFFATFTLCEAARRASKALLPVGAYEVFAREAVGAVQLGAC ::...... : :: ... : . ..:. : ... :: : NP_766 MSPLLGLRSELQDTCTSLGLMLSVVLLMGLARVVARQQLHRPVAHAFVLEFLATFQLCCC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 FLEMRTLVELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEESLPG :.. : : : : :::.... :.::.:: :.:.:: ....... : NP_766 THELQLLSEQHPAH----PTWTLTLVYFFSLVHGLTLVGTSSNPCGVMMQMMLGGMSPET 70 80 90 100 110 120 130 140 150 160 pF1KE6 TLLKLAAQGLGMQAACTLTRLC----WAWELSDLHLLQSLMAQSCSSALRTSVPHGALVE ..: :: .. : :. : : :. :.. :. . .: :.. .:... .....: NP_766 GAVRLLAQLVS--ALCS--RYCTSALWSLGLTQYHVSERSFA--CKNPIRVDLLKAVITE 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 AACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGH :.:.: :: .:::... .: :.: .:..: .:.: :::::: :. : : . NP_766 AVCSFLFHSALLHFQEVRTKLRIHLLAALITFLVYAGGSLTGAVFNPALALSLHFMCFDE 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE6 TLLEYVQVYWLGPLTGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQT .. .. ::::.: :..: .:. . :: : NP_766 AFPQFFIVYWLAPSLGILLMILMFSFFLPWLHNNHTINKKE 240 250 260 270 290 300 pF1KE6 PAKGSSVREPGRSGVEGPHSS >>XP_005273974 (OMIM: 609914) PREDICTED: aquaporin-11 is (232 aa) initn: 182 init1: 98 opt: 239 Z-score: 279.9 bits: 59.5 E(85289): 7.4e-09 Smith-Waterman score: 239; 28.1% identity (58.5% similar) in 217 aa overlap (7-215:17-222) 10 20 30 40 50 pF1KE6 MAGLNVSLSFFFATFTLCEAARRASKALLPVGAYEVFAREAVGAVQLGAC ::...... : :: ... : . ..:. : ... :: : XP_005 MSPLLGLRSELQDTCTSLGLMLSVVLLMGLARVVARQQLHRPVAHAFVLEFLATFQLCCC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 FLEMRTLVELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEESLPG :.. : : : : :::.... :.::.:: :.:.:: ....... : XP_005 THELQLLSEQHPAH----PTWTLTLVYFFSLVHGLTLVGTSSNPCGVMMQMMLGGMSPET 70 80 90 100 110 120 130 140 150 160 pF1KE6 TLLKLAAQGLGMQAACTLTRLC----WAWELSDLHLLQSLMAQSCSSALRTSVPHGALVE ..: :: .. : :. : : :. :.. :. . .: :.. .:... .....: XP_005 GAVRLLAQLVS--ALCS--RYCTSALWSLGLTQYHVSERSFA--CKNPIRVDLLKAVITE 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 AACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGPFTS----AFFNPALAASVTFA :.:.: :: .:::... .: :.: .: :: . .:: : : XP_005 AVCSFLFHSALLHFQEVRTKLRIHLLAALITFLVY-AGILLMILMFSFFLPWLHNNHTIN 180 190 200 210 220 230 240 250 260 270 280 pF1KE6 CSGHTLLEYVQVYWLGPLTGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASG XP_005 KKE 230 >>NP_001160 (OMIM: 603750) aquaporin-8 [Homo sapiens] (261 aa) initn: 140 init1: 63 opt: 150 Z-score: 177.5 bits: 40.7 E(85289): 0.0038 Smith-Waterman score: 150; 25.0% identity (54.0% similar) in 248 aa overlap (17-249:7-245) 10 20 30 40 50 pF1KE6 MAGLNVSLSFFFATFTLCEAARRASKALLP-VGA------YEVFAREAVGAVQLGACFLE .:: .:: : ::. :: :.. . . .: :. NP_001 MSGEIAMCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIF 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 MRTL--VELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEESLPGT . : .: : .: . : : : . : .: ...:. ::.::: .:.. .: NP_001 IGCLSVIENGTDTGLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVML 60 70 80 90 100 110 120 130 140 150 160 pF1KE6 LLKLAAQGLGMQAACTLTRLCWA----WELSDLHLLQSLMAQSCSSALRTSVPHGALVEA : ..: :: . . .:.. :. : .. . ..:: . . .:. NP_001 LPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQEQGQVAGALVAEIILTTLL-- 120 130 140 150 160 170 180 190 200 210 220 pF1KE6 ACAFCFHLTLLHLRHSPPAYSGP-AVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGH : : : . .. . . : .: .... ::: ..:: ... .::: : . . . ..: NP_001 ALAVC--MGAINEKTKGPL--APFSIGFAVTVDILAGGPVSGGCMNPARAFGPAVV-ANH 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE6 TLLEYVQVYWLGPL-TGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQ .. .:::::: .:.....:. NP_001 --WNFHWIYWLGPLLAGLLVGLLIRCFIGDGKTRLILKAR 230 240 250 260 >>XP_011544124 (OMIM: 603750) PREDICTED: aquaporin-8 iso (262 aa) initn: 140 init1: 63 opt: 150 Z-score: 177.5 bits: 40.7 E(85289): 0.0038 Smith-Waterman score: 150; 25.0% identity (54.0% similar) in 248 aa overlap (17-249:8-246) 10 20 30 40 50 pF1KE6 MAGLNVSLSFFFATFTLCEAARRASKALLP-VGA------YEVFAREAVGAVQLGACFLE .:: .:: : ::. :: :.. . . .: :. XP_011 MSGEQIAMCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIF 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 MRTL--VELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEESLPGT . : .: : .: . : : : . : .: ...:. ::.::: .:.. .: XP_011 IGCLSVIENGTDTGLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVML 60 70 80 90 100 110 120 130 140 150 160 pF1KE6 LLKLAAQGLGMQAACTLTRLCWA----WELSDLHLLQSLMAQSCSSALRTSVPHGALVEA : ..: :: . . .:.. :. : .. . ..:: . . .:. XP_011 LPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQEQGQVAGALVAEIILTTLL-- 120 130 140 150 160 170 180 190 200 210 220 pF1KE6 ACAFCFHLTLLHLRHSPPAYSGP-AVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGH : : : . .. . . : .: .... ::: ..:: ... .::: : . . . ..: XP_011 ALAVC--MGAINEKTKGPL--APFSIGFAVTVDILAGGPVSGGCMNPARAFGPAVV-ANH 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE6 TLLEYVQVYWLGPL-TGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQ .. .:::::: .:.....:. XP_011 --WNFHWIYWLGPLLAGLLVGLLIRCFIGDGKTRLILKAR 230 240 250 260 307 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:48:48 2016 done: Tue Nov 8 11:48:48 2016 Total Scan time: 4.720 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]