FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3270, 673 aa 1>>>pF1KE3270 673 - 673 aa - 673 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4372+/-0.000312; mu= 16.2376+/- 0.020 mean_var=135.5846+/-27.469, 0's: 0 Z-trim(121.6): 329 B-trim: 500 in 1/52 Lambda= 0.110146 statistics sampled from 37930 (38387) to 37930 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.777), E-opt: 0.2 (0.45), width: 16 Scan time: 13.740 The best scores are: opt bits E(85289) NP_733749 (OMIM: 607320) RAS guanyl-releasing prot ( 673) 4690 756.8 5.8e-218 NP_001139674 (OMIM: 607320) RAS guanyl-releasing p ( 659) 3415 554.2 5.6e-157 NP_001139677 (OMIM: 607320) RAS guanyl-releasing p ( 639) 2949 480.1 1.1e-134 NP_001139679 (OMIM: 607320) RAS guanyl-releasing p ( 576) 2530 413.5 1.1e-114 NP_001139675 (OMIM: 607320) RAS guanyl-releasing p ( 581) 2185 358.7 3.5e-98 NP_001139676 (OMIM: 607320) RAS guanyl-releasing p ( 604) 2169 356.2 2.1e-97 NP_001139678 (OMIM: 607320) RAS guanyl-releasing p ( 484) 1913 315.4 3.2e-85 XP_011519453 (OMIM: 603962) PREDICTED: RAS guanyl- ( 632) 1903 313.9 1.2e-84 NP_005730 (OMIM: 603962) RAS guanyl-releasing prot ( 797) 1903 314.0 1.4e-84 XP_016877349 (OMIM: 603962) PREDICTED: RAS guanyl- ( 749) 1884 311.0 1.1e-83 XP_005254171 (OMIM: 603962) PREDICTED: RAS guanyl- ( 746) 1782 294.7 8e-79 XP_016859248 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 1658 275.0 6.5e-73 XP_016859249 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 1658 275.0 6.5e-73 NP_733772 (OMIM: 609531) ras guanyl-releasing prot ( 690) 1658 275.0 6.5e-73 XP_011531050 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 1658 275.0 6.5e-73 XP_011531048 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 1658 275.0 6.5e-73 XP_016859250 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 1658 275.0 6.5e-73 XP_011531049 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 1658 275.0 6.5e-73 NP_001132960 (OMIM: 609531) ras guanyl-releasing p ( 690) 1658 275.0 6.5e-73 XP_005264303 (OMIM: 609531) PREDICTED: ras guanyl- ( 689) 1648 273.4 1.9e-72 XP_016859251 (OMIM: 609531) PREDICTED: ras guanyl- ( 689) 1648 273.4 1.9e-72 NP_056191 (OMIM: 609531) ras guanyl-releasing prot ( 689) 1648 273.4 1.9e-72 XP_016859252 (OMIM: 609531) PREDICTED: ras guanyl- ( 689) 1648 273.4 1.9e-72 NP_001092140 (OMIM: 605577,615888) RAS guanyl-rele ( 609) 1616 268.3 6.1e-71 NP_722541 (OMIM: 605577,615888) RAS guanyl-releasi ( 609) 1616 268.3 6.1e-71 NP_001092141 (OMIM: 605577,615888) RAS guanyl-rele ( 609) 1616 268.3 6.1e-71 XP_011543023 (OMIM: 605577,615888) PREDICTED: RAS ( 610) 1616 268.3 6.1e-71 XP_016872573 (OMIM: 605577,615888) PREDICTED: RAS ( 610) 1616 268.3 6.1e-71 XP_011543025 (OMIM: 605577,615888) PREDICTED: RAS ( 610) 1616 268.3 6.1e-71 XP_011543024 (OMIM: 605577,615888) PREDICTED: RAS ( 610) 1616 268.3 6.1e-71 XP_011543022 (OMIM: 605577,615888) PREDICTED: RAS ( 610) 1616 268.3 6.1e-71 XP_005273764 (OMIM: 605577,615888) PREDICTED: RAS ( 714) 1483 247.2 1.6e-64 XP_011543020 (OMIM: 605577,615888) PREDICTED: RAS ( 715) 1483 247.2 1.6e-64 XP_016872572 (OMIM: 605577,615888) PREDICTED: RAS ( 897) 1483 247.3 1.8e-64 XP_016872571 (OMIM: 605577,615888) PREDICTED: RAS ( 898) 1483 247.3 1.8e-64 XP_016872574 (OMIM: 605577,615888) PREDICTED: RAS ( 551) 1412 235.8 3.2e-61 NP_001305327 (OMIM: 605577,615888) RAS guanyl-rele ( 464) 1325 221.9 4.2e-57 XP_011543027 (OMIM: 605577,615888) PREDICTED: RAS ( 465) 1325 221.9 4.2e-57 XP_016872575 (OMIM: 605577,615888) PREDICTED: RAS ( 465) 1325 221.9 4.2e-57 NP_001293015 (OMIM: 603962) RAS guanyl-releasing p ( 597) 1261 211.9 5.7e-54 NP_001122074 (OMIM: 603962) RAS guanyl-releasing p ( 762) 1261 212.0 6.8e-54 XP_016865171 (OMIM: 606614) PREDICTED: ras-specifi (1142) 295 58.6 1.5e-07 NP_008840 (OMIM: 606614) ras-specific guanine nucl (1237) 295 58.7 1.6e-07 XP_011531368 (OMIM: 135300,182530,610733) PREDICTE ( 978) 280 56.2 6.9e-07 XP_011531366 (OMIM: 135300,182530,610733) PREDICTE (1276) 280 56.3 8.3e-07 XP_005264572 (OMIM: 135300,182530,610733) PREDICTE (1318) 280 56.3 8.5e-07 XP_011531364 (OMIM: 135300,182530,610733) PREDICTE (1326) 280 56.3 8.5e-07 NP_005624 (OMIM: 135300,182530,610733) son of seve (1333) 280 56.3 8.5e-07 NP_005303 (OMIM: 600303) rap guanine nucleotide ex (1077) 276 55.6 1.1e-06 NP_001291204 (OMIM: 600303) rap guanine nucleotide (1094) 276 55.6 1.2e-06 >>NP_733749 (OMIM: 607320) RAS guanyl-releasing protein (673 aa) initn: 4690 init1: 4690 opt: 4690 Z-score: 4034.1 bits: 756.8 E(85289): 5.8e-218 Smith-Waterman score: 4690; 100.0% identity (100.0% similar) in 673 aa overlap (1-673:1-673) 10 20 30 40 50 60 pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 610 620 630 640 650 660 670 pF1KE3 MDPPSTASSKLDS ::::::::::::: NP_733 MDPPSTASSKLDS 670 >>NP_001139674 (OMIM: 607320) RAS guanyl-releasing prote (659 aa) initn: 4570 init1: 3415 opt: 3415 Z-score: 2939.2 bits: 554.2 E(85289): 5.6e-157 Smith-Waterman score: 4546; 97.9% identity (97.9% similar) in 673 aa overlap (1-673:1-659) 10 20 30 40 50 60 pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL---------- 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ----PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 180 190 200 210 220 250 260 270 280 290 300 pF1KE3 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE3 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE3 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE3 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE3 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE3 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 530 540 550 560 570 580 610 620 630 640 650 660 pF1KE3 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 590 600 610 620 630 640 670 pF1KE3 MDPPSTASSKLDS ::::::::::::: NP_001 MDPPSTASSKLDS 650 >>NP_001139677 (OMIM: 607320) RAS guanyl-releasing prote (639 aa) initn: 2949 init1: 2949 opt: 2949 Z-score: 2539.2 bits: 480.1 E(85289): 1.1e-134 Smith-Waterman score: 4381; 94.9% identity (94.9% similar) in 673 aa overlap (1-673:1-639) 10 20 30 40 50 60 pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL ::::::::::::::::::::::::::::::::::::::::: NP_001 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT------------------- 190 200 210 220 250 260 270 280 290 300 pF1KE3 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS ::::::::::::::::::::::::::::::::::::::::::::: NP_001 ---------------VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 230 240 250 260 310 320 330 340 350 360 pF1KE3 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE3 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE3 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 390 400 410 420 430 440 490 500 510 520 530 540 pF1KE3 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 450 460 470 480 490 500 550 560 570 580 590 600 pF1KE3 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 510 520 530 540 550 560 610 620 630 640 650 660 pF1KE3 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 570 580 590 600 610 620 670 pF1KE3 MDPPSTASSKLDS ::::::::::::: NP_001 MDPPSTASSKLDS 630 >>NP_001139679 (OMIM: 607320) RAS guanyl-releasing prote (576 aa) initn: 4029 init1: 2530 opt: 2530 Z-score: 2179.9 bits: 413.5 E(85289): 1.1e-114 Smith-Waterman score: 3839; 85.6% identity (85.6% similar) in 673 aa overlap (1-673:1-576) 10 20 30 40 50 60 pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL ::::::::::::::::::::::::::::::::::::::::: NP_001 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT------------------- 190 200 210 220 250 260 270 280 290 300 pF1KE3 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS NP_001 ------------------------------------------------------------ 310 320 330 340 350 360 pF1KE3 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS :::::::::::::::::::::::::::::::::::::::::: NP_001 ------------------ALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 230 240 250 260 370 380 390 400 410 420 pF1KE3 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 270 280 290 300 310 320 430 440 450 460 470 480 pF1KE3 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 330 340 350 360 370 380 490 500 510 520 530 540 pF1KE3 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 390 400 410 420 430 440 550 560 570 580 590 600 pF1KE3 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 450 460 470 480 490 500 610 620 630 640 650 660 pF1KE3 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 510 520 530 540 550 560 670 pF1KE3 MDPPSTASSKLDS ::::::::::::: NP_001 MDPPSTASSKLDS 570 >>NP_001139675 (OMIM: 607320) RAS guanyl-releasing prote (581 aa) initn: 2227 init1: 2167 opt: 2185 Z-score: 1883.6 bits: 358.7 E(85289): 3.5e-98 Smith-Waterman score: 3872; 86.3% identity (86.3% similar) in 673 aa overlap (1-673:1-581) 10 20 30 40 50 60 pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS :::::::::::::::::: NP_001 AISRLKDSHAHLSPDSTK------------------------------------------ 310 370 380 390 400 410 420 pF1KE3 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED :::::::::: NP_001 --------------------------------------------------LSLDLFYTED 320 430 440 450 460 470 480 pF1KE3 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 330 340 350 360 370 380 490 500 510 520 530 540 pF1KE3 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 390 400 410 420 430 440 550 560 570 580 590 600 pF1KE3 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 450 460 470 480 490 500 610 620 630 640 650 660 pF1KE3 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 510 520 530 540 550 560 670 pF1KE3 MDPPSTASSKLDS ::::::::::::: NP_001 MDPPSTASSKLDS 570 580 >>NP_001139676 (OMIM: 607320) RAS guanyl-releasing prote (604 aa) initn: 2229 init1: 2169 opt: 2169 Z-score: 1869.6 bits: 356.2 E(85289): 2.1e-97 Smith-Waterman score: 4075; 89.7% identity (89.7% similar) in 673 aa overlap (1-673:1-604) 10 20 30 40 50 60 pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS :::::::::::::::::: NP_001 AISRLKDSHAHLSPDSTK------------------------------------------ 310 370 380 390 400 410 420 pF1KE3 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED ::::::::::::::::::::::::::::::::: NP_001 ---------------------------ELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 320 330 340 350 430 440 450 460 470 480 pF1KE3 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 360 370 380 390 400 410 490 500 510 520 530 540 pF1KE3 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 420 430 440 450 460 470 550 560 570 580 590 600 pF1KE3 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 480 490 500 510 520 530 610 620 630 640 650 660 pF1KE3 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 540 550 560 570 580 590 670 pF1KE3 MDPPSTASSKLDS ::::::::::::: NP_001 MDPPSTASSKLDS 600 >>NP_001139678 (OMIM: 607320) RAS guanyl-releasing prote (484 aa) initn: 1913 init1: 1913 opt: 1913 Z-score: 1651.0 bits: 315.4 E(85289): 3.2e-85 Smith-Waterman score: 3031; 71.9% identity (71.9% similar) in 673 aa overlap (1-673:1-484) 10 20 30 40 50 60 pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL ::::::::::::::::::::::::::::::::::::::::: NP_001 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT------------------- 190 200 210 220 250 260 270 280 290 300 pF1KE3 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS NP_001 ------------------------------------------------------------ 310 320 330 340 350 360 pF1KE3 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS NP_001 ------------------------------------------------------------ 370 380 390 400 410 420 pF1KE3 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED :::::::::: NP_001 --------------------------------------------------LSLDLFYTED 230 430 440 450 460 470 480 pF1KE3 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 240 250 260 270 280 290 490 500 510 520 530 540 pF1KE3 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 300 310 320 330 340 350 550 560 570 580 590 600 pF1KE3 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 360 370 380 390 400 410 610 620 630 640 650 660 pF1KE3 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 420 430 440 450 460 470 670 pF1KE3 MDPPSTASSKLDS ::::::::::::: NP_001 MDPPSTASSKLDS 480 >>XP_011519453 (OMIM: 603962) PREDICTED: RAS guanyl-rele (632 aa) initn: 1877 init1: 1483 opt: 1903 Z-score: 1640.9 bits: 313.9 E(85289): 1.2e-84 Smith-Waterman score: 1903; 48.4% identity (76.2% similar) in 601 aa overlap (4-602:8-601) 10 20 30 40 50 pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRR-HKTCPSPREISKVMASMNLGLLSEGG ... :: . : . .: . . . . :: .:.. ..:: :..:. XP_011 MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 CSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQE : :.:...::::::. :.::. ...:...:.:: :. ::.: ...: :. : . .. XP_011 -SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSP 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 LRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGG :.::..::::. . ....: .: ... .: : .:. . :: :.... . XP_011 GLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDW 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 PGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVR . . .::::::::::::: ::..:::::::.::. :. .: ..:.... :. XP_011 SRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 GCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTG :..: :..: :..:.:::.:::::: : ::.:. :::.:::.::::::::::::: : XP_011 ENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 GLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHL :::::.:::::.. .:. . .:.: :.::::.: :: :::... :. :..:.::::: XP_011 GLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHL 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 KDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDL :::.::.::.:: : ::.... :: :: ...::: :: :: ::.::.::::::::: XP_011 KDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDL 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE3 FYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVF .:::::::::::::::: .. : .: . :.::.:: ::.:::: :...::...:.::: XP_011 YYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVF 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE3 KNYDPEGRGTISQEDFERLSGNFPFA-CHGLHPPPRQGRGSFSREELTGYLLRASAICSK :::: . : ::::.::.....:::. : . :.: .::.:.:.:..:::.: :: XP_011 KNYDHDQDGYISQEEFEKIAASFPFSFC--VMDKDREG--LISRDEITAYFMRASSIYSK 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE3 LGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRP :::.: :.:.:.:. ::::::.:.:::::: ::::::..::. :::.:.: : ::::: XP_011 LGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR- 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE3 GAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETD ::. ..: XP_011 -AKNPVAPTENNTSVGPVSNLCSLGAKDLLHGNKYSESR 600 610 620 630 >>NP_005730 (OMIM: 603962) RAS guanyl-releasing protein (797 aa) initn: 1877 init1: 1483 opt: 1903 Z-score: 1639.7 bits: 314.0 E(85289): 1.4e-84 Smith-Waterman score: 1904; 47.0% identity (74.3% similar) in 634 aa overlap (4-634:8-629) 10 20 30 40 50 pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRR-HKTCPSPREISKVMASMNLGLLSEGG ... :: . : . .: . . . . :: .:.. ..:: :..:. NP_005 MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 CSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQE : :.:...::::::. :.::. ...:...:.:: :. ::.: ...: :. : . .. NP_005 -SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSP 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 LRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGG :.::..::::. . ....: .: ... .: : .:. . :: :.... . NP_005 GLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDW 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 PGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVR . . .::::::::::::: ::..:::::::.::. :. .: ..:.... :. NP_005 SRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 GCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTG :..: :..: :..:.:::.:::::: : ::.:. :::.:::.::::::::::::: : NP_005 ENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 GLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHL :::::.:::::.. .:. . .:.: :.::::.: :: :::... :. :..:.::::: NP_005 GLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHL 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 KDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDL :::.::.::.:: : ::.... :: :: ...::: :: :: ::.::.::::::::: NP_005 KDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDL 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE3 FYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVF .:::::::::::::::: .. : .: . :.::.:: ::.:::: :...::...:.::: NP_005 YYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVF 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE3 KNYDPEGRGTISQEDFERLSGNFPFA-CHGLHPPPRQGRGSFSREELTGYLLRASAICSK :::: . : ::::.::.....:::. : . :.: .::.:.:.:..:::.: :: NP_005 KNYDHDQDGYISQEEFEKIAASFPFSFC--VMDKDREGL--ISRDEITAYFMRASSIYSK 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE3 LGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRP :::.: :.:.:.:. ::::::.:.:::::: ::::::..::. :::.:.: : ::::: NP_005 LGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR- 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE3 GAKGDAGPPGAPVPSTPAPH-ASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWET ::. ..: . :. . : :... : :: : NP_005 -AKNPVAPTENNTSVGPVSNLCSLGAKD-----LLHAPEEGPFTFPNGEAVEHGEESKDR 600 610 620 630 640 660 670 pF1KE3 DTVPCPVMDPPSTASSKLDS NP_005 TIMLMGVSSQKISLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPS 650 660 670 680 690 700 >>XP_016877349 (OMIM: 603962) PREDICTED: RAS guanyl-rele (749 aa) initn: 1877 init1: 1483 opt: 1884 Z-score: 1623.7 bits: 311.0 E(85289): 1.1e-83 Smith-Waterman score: 1885; 49.2% identity (76.3% similar) in 591 aa overlap (46-634:3-581) 20 30 40 50 60 70 pF1KE3 GKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSL ..:: :..:. : :.:...::::::. :.: XP_016 MMVSLGHLAKGA-SLDDLIDSCIQSFDADGNL 10 20 30 80 90 100 110 120 130 pF1KE3 CHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEV :. ...:...:.:: :. ::.: ...: :. : . .. :.::..::::. . . XP_016 CRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVM 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE3 MHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSL ...: .: ... .: : .:. . :: :.... . . . .::::::: XP_016 FKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSL 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE3 LFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQ :::::: ::..:::::::.::. :. .: ..:.... :. :..: :..: :..:.::: XP_016 LFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQ 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE3 VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPD .:::::: : ::.:. :::.:::.::::::::::::: ::::::.:::::.. .:. . XP_016 LMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHE 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE3 STKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLH .:.: :.::::.: :: :::... :. :..:.::::::::.::.::.:: : ::... XP_016 INKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVN 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE3 LPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPK . :: :: ...::: :: :: ::.::.:::::::::.:::::::::::::::: . XP_016 VHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHR 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE3 SLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLS . : .: . :.::.:: ::.:::: :...::...:.::::::: . : ::::.::... XP_016 APPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIA 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE3 GNFPFA-CHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFC ..:::. : . :.: .::.:.:.:..:::.: :::::.: :.:.:.:. ::::: XP_016 ASFPFSFC--VMDKDREGL--ISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFC 460 470 480 490 500 560 570 580 590 600 610 pF1KE3 DSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPH :.:.:::::: ::::::..::. :::.:.: : ::::: ::. ..: . :. . XP_016 DNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR--AKNPVAPTENNTSVGPVSN 510 520 530 540 550 560 620 630 640 650 660 670 pF1KE3 -ASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS : :... : :: : XP_016 LCSLGAKD-----LLHAPEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKISLRLKRAV 570 580 590 600 610 620 673 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 10:36:05 2016 done: Sun Nov 6 10:36:07 2016 Total Scan time: 13.740 Total Display time: 0.170 Function used was FASTA [36.3.4 Apr, 2011]