Result of FASTA (omim) for
pFN21AE1249
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1249, 494 aa
1>>>pF1KE1249 494 - 494 aa - 494 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.5132+/-0.000444; mu= -10.7850+/- 0.028
mean_var=603.1425+/-125.707, 0's: 0 Z-trim(125.1): 27 B-trim: 861 in 1/57
Lambda= 0.052223
statistics sampled from 48121 (48170) to 48121 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.807), E-opt: 0.2 (0.565), width: 16
Scan time: 10.320
The best scores are: opt bits E(85289)
NP_001073957 (OMIM: 611294) one cut domain family ( 494) 3398 270.5 7.6e-72
NP_004843 (OMIM: 604894) one cut domain family mem ( 504) 1038 92.7 2.6e-18
NP_004489 (OMIM: 604164) hepatocyte nuclear factor ( 465) 1028 91.9 4.1e-18
XP_016881585 (OMIM: 604894) PREDICTED: one cut dom ( 480) 612 60.6 1.1e-08
XP_011519789 (OMIM: 604164) PREDICTED: hepatocyte ( 402) 593 59.1 2.8e-08
>>NP_001073957 (OMIM: 611294) one cut domain family memb (494 aa)
initn: 3398 init1: 3398 opt: 3398 Z-score: 1410.9 bits: 270.5 E(85289): 7.6e-72
Smith-Waterman score: 3398; 100.0% identity (100.0% similar) in 494 aa overlap (1-494:1-494)
10 20 30 40 50 60
pF1KE1 MELSLESLGGLHSVAHAQAGELLSPGHARSAAAQHRGLVAPGRPGLVAGMASLLDGGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MELSLESLGGLHSVAHAQAGELLSPGHARSAAAQHRGLVAPGRPGLVAGMASLLDGGGGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GGGGAGGAGGAGSAGGGADFRGELAGPLHPAMGMACEAPGLGGTYTTLTPLQHLPPLAAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGGAGGAGGAGSAGGGADFRGELAGPLHPAMGMACEAPGLGGTYTTLTPLQHLPPLAAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 ADKFHQHAAAAAVAGAHGGHPHAHPHPAAAPPPPPPPQRLAASVSGSFTLMRDERAALAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADKFHQHAAAAAVAGAHGGHPHAHPHPAAAPPPPPPPQRLAASVSGSFTLMRDERAALAS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VGHLYGPYGKELPAMGSPLSPLPNALPPALHGAPQPPPPPPPPPLAAYGPPGHLAGDKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGHLYGPYGKELPAMGSPLSPLPNALPPALHGAPQPPPPPPPPPLAAYGPPGHLAGDKLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PPAAFEPHAALLGRAEDALARGLPGGGGGTGSGGAGSGSAAGLLAPLGGLAAAGAHGPHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPAAFEPHAALLGRAEDALARGLPGGGGGTGSGGAGSGSAAGLLAPLGGLAAAGAHGPHG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 GGGGPGGSGGGPSAGAAAEEINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGGPGGSGGGPSAGAAAEEINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 RNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEQQKERALQPKKQRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEQQKERALQPKKQRLV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 FTDLQRRTLIAIFKENKRPSKEMQVTISQQLGLELNTVSNFFMNARRRCMNRWAEEPSTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTDLQRRTLIAIFKENKRPSKEMQVTISQQLGLELNTVSNFFMNARRRCMNRWAEEPSTA
430 440 450 460 470 480
490
pF1KE1 PGGPAGATATFSKA
::::::::::::::
NP_001 PGGPAGATATFSKA
490
>>NP_004843 (OMIM: 604894) one cut domain family member (504 aa)
initn: 1167 init1: 949 opt: 1038 Z-score: 449.8 bits: 92.7 E(85289): 2.6e-18
Smith-Waterman score: 1452; 52.4% identity (69.1% similar) in 531 aa overlap (2-494:23-504)
10 20
pF1KE1 MELSLESLGGLHSVAHAQAG------------------E
::..:::: ::. : . .: :
NP_004 MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPAGGGSGGGGGGGGGGGGGGPGHEQE
10 20 30 40 50 60
30 40 50 60 70
pF1KE1 LL---SPGHA-RSAAAQHRGLVAPGRPGLVAGMASLLDGGGGGGGGGAGGAGGAGSAGGG
:: :: :: :.::.. :: : : :. ....... .. . . .: :
NP_004 LLASPSPHHAGRGAAGSLRGPPPPPTAHQELGTAA----AAAAAASRSAMVTSMASILDG
70 80 90 100 110
80 90 100 110 120 130
pF1KE1 ADFRGELAGPLHPAMGMACEA--PGLG--GTYTTLTPLQHLPPLAAVADKFHQHAAAAAV
.:.: ::. ::: ::.:.:.. ::.: .::::::::: :::...:.::::.
NP_004 GDYRPELSIPLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPISTVSDKFHHP------
120 130 140 150 160 170
140 150 160 170 180 190
pF1KE1 AGAHGGHPHAHPHPAAAPPPPPPPQRLAASVSGSFTLMRDERAALASVGHLYGPYGKELP
::: ::: :::...::::::::::::. : ....::.:: ::.:
NP_004 ------HPHHHPHHHHH----HHHQRLSGNVSGSFTLMRDERG-LPAMNNLYSPY-KEMP
180 190 200 210
200 210 220 230 240
pF1KE1 AMGSPLSPLPNALP-----PALHGAPQPPPPPPPPPLAAYGPPGHLAGDKLLPPAAFEPH
.:.. :::: : : .::.: : : :::::: ::.: : :
NP_004 GMSQSLSPLA-ATPLGNGLGGLHNAQQSLP--------NYGPPGH---DKMLSPNFDAHH
220 230 240 250 260
250 260 270 280 290 300
pF1KE1 AALLGRAEDALARGLPGGGGGTGSGGAGSGSAAGLLAPLGGLAAAG---AHGPHGGGG--
.:.: :.:. :.::: :. :: ... :.:: : .::: . .
NP_004 TAMLTRGEQHLSRGL------------GTPPAA-MMSHLNGLHHPGHTQSHGPVLAPSRE
270 280 290 300 310
310 320 330 340 350 360
pF1KE1 -GPGGSGGGPSAGAAA-EEINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLLR
:..:.:. : .. :::::::::::::::::::::::::::::.:::::::::::::
NP_004 RPPSSSSGSQVATSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLSDLLR
320 330 340 350 360 370
370 380 390 400 410 420
pF1KE1 NPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEQQKERALQPKKQRLVF
:::::::::::::::::::::::::::::::::::::::::::: .:.: . ::.::::
NP_004 NPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEPNKDRNNSQKKSRLVF
380 390 400 410 420 430
430 440 450 460 470 480
pF1KE1 TDLQRRTLIAIFKENKRPSKEMQVTISQQLGLELNTVSNFFMNARRRCMNRWAEEPSTAP
::::::::.::::::::::::::.::::::::::.:::::::::::: ...: .. ::
NP_004 TDLQRRTLFAIFKENKRPSKEMQITISQQLGLELTTVSNFFMNARRRSLEKWQDDLST--
440 450 460 470 480 490
490
pF1KE1 GGPAGATATFSKA
:: .....: .::
NP_004 GGSSSTSSTCTKA
500
>>NP_004489 (OMIM: 604164) hepatocyte nuclear factor 6 [ (465 aa)
initn: 1320 init1: 963 opt: 1028 Z-score: 446.1 bits: 91.9 E(85289): 4.1e-18
Smith-Waterman score: 1500; 54.3% identity (70.6% similar) in 506 aa overlap (2-494:4-465)
10 20 30 40 50
pF1KE1 MELSLESLGGLHSVAH----AQAGELLSPGHARSAAAQHRGL-VAPGRPGLVAGMASL
.:..:..: ::.:.: : : : . ::::..: ::: . :..: . :::::
NP_004 MNAQLTMEAIGELHGVSHEPVPAPADLLGGSPHARSSVA-HRGSHLPPAHPRSM-GMASL
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 LDGGGGGGGGGAGGAGGAGSAGGGADFRGELAGPLHPAMGMACEAP-GLG--GTYTTLTP
::::.::: . : :::::::.: ::::.: :.. :::::::
NP_004 LDGGSGGGDYHHHHRAPEHS----------LAGPLHPTMTMACETPPGMSMPTTYTTLTP
60 70 80 90 100
120 130 140 150 160
pF1KE1 LQHLPPLAAVADKF-HQHAAAAAVAGAHGGHPHAHPHPAAAPPPPPPPQRLAASVSGSFT
:: :::...:.::: :.: : : : ::: ::::..::::::
NP_004 LQPLPPISTVSDKFPHHH---------HHHHHHHHPHHH---------QRLAGNVSGSFT
110 120 130 140 150
170 180 190 200 210 220
pF1KE1 LMRDERAALASVGHLYGPYGKELPAMGSPLSPLPNALPPALHGAPQPPPPPPPPPLAAYG
::::::. :::...:: :: :.. .::. :::: .. ..:.. : : :.
NP_004 LMRDERG-LASMNNLYTPYHKDVAGMGQSLSPLSSSGLGSIHNSQQGLPH--------YA
160 170 180 190 200
230 240 250 260 270 280
pF1KE1 PPGH-LAGDKLLPPAAFEPH-AALLGR-AEDALARGLPGGGGGTGSGGAGSGSAAGLLAP
:: . ::.: : .:: : :.::: .:. :. : ..: . .: . :
NP_004 HPGAAMPTDKMLTPNGFEAHHPAMLGRHGEQHLT---PTSAGMVPINGLPPHHPHAHLNA
210 220 230 240 250
290 300 310 320 330 340
pF1KE1 LG-GLAAAGAHGPHGGGGGPGGSGGGPSAGAAAEEINTKEVAQRITAELKRYSIPQAIFA
: : . :. :. . : :.: : .. :::::::::::::.:::::::::::::
NP_004 QGHGQLLGTAREPNPSVTGAQVSNG--SNSGQMEEINTKEVAQRITTELKRYSIPQAIFA
260 270 280 290 300 310
350 360 370 380 390 400
pF1KE1 QRILCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQE
::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQE
320 330 340 350 360 370
410 420 430 440 450 460
pF1KE1 QQKERALQPKKQRLVFTDLQRRTLIAIFKENKRPSKEMQVTISQQLGLELNTVSNFFMNA
. :.:. ::: ::::::.::::: ::::::::::::.:.::::::::::.:::::::::
NP_004 HGKDRGNTPKKPRLVFTDVQRRTLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNA
380 390 400 410 420 430
470 480 490
pF1KE1 RRRCMNRWAEEPSTAPGGPAGATATFSKA
::: ...: .: :. :. .....: .::
NP_004 RRRSLDKWQDEGSSNSGNSSSSSSTCTKA
440 450 460
>>XP_016881585 (OMIM: 604894) PREDICTED: one cut domain (480 aa)
initn: 755 init1: 537 opt: 612 Z-score: 276.6 bits: 60.6 E(85289): 1.1e-08
Smith-Waterman score: 1026; 48.7% identity (64.8% similar) in 435 aa overlap (2-398:23-410)
10 20
pF1KE1 MELSLESLGGLHSVAHAQAG------------------E
::..:::: ::. : . .: :
XP_016 MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPAGGGSGGGGGGGGGGGGGGPGHEQE
10 20 30 40 50 60
30 40 50 60 70
pF1KE1 LL---SPGHA-RSAAAQHRGLVAPGRPGLVAGMASLLDGGGGGGGGGAGGAGGAGSAGGG
:: :: :: :.::.. :: : : :. ....... .. . . .: :
XP_016 LLASPSPHHAGRGAAGSLRGPPPPPTAHQELGTAA----AAAAAASRSAMVTSMASILDG
70 80 90 100 110
80 90 100 110 120 130
pF1KE1 ADFRGELAGPLHPAMGMACEA--PGLG--GTYTTLTPLQHLPPLAAVADKFHQHAAAAAV
.:.: ::. ::: ::.:.:.. ::.: .::::::::: :::...:.:::: :
XP_016 GDYRPELSIPLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPISTVSDKFH-HP-----
120 130 140 150 160 170
140 150 160 170 180 190
pF1KE1 AGAHGGHPHAHPHPAAAPPPPPPPQRLAASVSGSFTLMRDERAALASVGHLYGPYGKELP
::: ::: :::...::::::::::::. : ....::.:: ::.:
XP_016 ------HPHHHPHHHHHH----HHQRLSGNVSGSFTLMRDERG-LPAMNNLYSPY-KEMP
180 190 200 210
200 210 220 230 240
pF1KE1 AMGSPLSPLPNALP-----PALHGAPQPPPPPPPPPLAAYGPPGHLAGDKLLPPAAFEPH
.:.. :::: : : .::.: : : :::::: ::.: : :
XP_016 GMSQSLSPLA-ATPLGNGLGGLHNAQQSLP--------NYGPPGH---DKMLSPNFDAHH
220 230 240 250 260
250 260 270 280 290 300
pF1KE1 AALLGRAEDALARGLPGGGGGTGSGGAGSGSAAGLLAPLGGLAAAG---AHGPHGGGG--
.:.: :.:. :.::: :. :: ... :.:: : .::: . .
XP_016 TAMLTRGEQHLSRGL------------GTPPAA-MMSHLNGLHHPGHTQSHGPVLAPSRE
270 280 290 300 310
310 320 330 340 350 360
pF1KE1 -GPGGSGGGPSAGAAA-EEINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLLR
:..:.:. : .. :::::::::::::::::::::::::::::.:::::::::::::
XP_016 RPPSSSSGSQVATSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLSDLLR
320 330 340 350 360 370
370 380 390 400 410 420
pF1KE1 NPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEQQKERALQPKKQRLVF
:::::::::::::::::::::::::::::::::::::
XP_016 NPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAAAILMGMRSNKLSTGRTGCQSSEG
380 390 400 410 420 430
430 440 450 460 470 480
pF1KE1 TDLQRRTLIAIFKENKRPSKEMQVTISQQLGLELNTVSNFFMNARRRCMNRWAEEPSTAP
XP_016 EPGFQTPAQCLATSLLKLKRNHLPYSMCKFSRQILLYPALTPGSRRC
440 450 460 470 480
>>XP_011519789 (OMIM: 604164) PREDICTED: hepatocyte nucl (402 aa)
initn: 880 init1: 523 opt: 593 Z-score: 269.8 bits: 59.1 E(85289): 2.8e-08
Smith-Waterman score: 1065; 50.2% identity (66.0% similar) in 420 aa overlap (2-409:4-380)
10 20 30 40 50
pF1KE1 MELSLESLGGLHSVAH----AQAGELLSPGHARSAAAQHRGL-VAPGRPGLVAGMASL
.:..:..: ::.:.: : : : . ::::..: ::: . :..: . :::::
XP_011 MNAQLTMEAIGELHGVSHEPVPAPADLLGGSPHARSSVA-HRGSHLPPAHPRSM-GMASL
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 LDGGGGGGGGGAGGAGGAGSAGGGADFRGELAGPLHPAMGMACEAP-GLG--GTYTTLTP
::::.::: . : :::::::.: ::::.: :.. :::::::
XP_011 LDGGSGGGDYHHHHRAPEHS----------LAGPLHPTMTMACETPPGMSMPTTYTTLTP
60 70 80 90 100
120 130 140 150 160 170
pF1KE1 LQHLPPLAAVADKFHQHAAAAAVAGAHGGHPHAHPHPAAAPPPPPPPQRLAASVSGSFTL
:: :::...:.::: .: : : : ::: ::::..:::::::
XP_011 LQPLPPISTVSDKFPHHH--------HHHHHHHHPHHH---------QRLAGNVSGSFTL
110 120 130 140 150
180 190 200 210 220 230
pF1KE1 MRDERAALASVGHLYGPYGKELPAMGSPLSPLPNALPPALHGAPQPPPPPPPPPLAAYGP
:::::. :::...:: :: :.. .::. :::: .. ..:.. : : :.
XP_011 MRDERG-LASMNNLYTPYHKDVAGMGQSLSPLSSSGLGSIHNSQQGLPH--------YAH
160 170 180 190 200
240 250 260 270 280
pF1KE1 PGH-LAGDKLLPPAAFEPH-AALLGR-AEDALARGLPGGGGGTGSGGAGSGSAAGLLAPL
:: . ::.: : .:: : :.::: .:. :. : ..: . .: . :
XP_011 PGAAMPTDKMLTPNGFEAHHPAMLGRHGEQHLT---PTSAGMVPINGLPPHHPHAHLNAQ
210 220 230 240 250
290 300 310 320 330 340
pF1KE1 G-GLAAAGAHGPHGGGGGPGGSGGGPSAGAAAEEINTKEVAQRITAELKRYSIPQAIFAQ
: : . :. :. . : :.: : .. :::::::::::::.::::::::::::::
XP_011 GHGQLLGTAREPNPSVTGAQVSNG--SNSGQMEEINTKEVAQRITTELKRYSIPQAIFAQ
260 270 280 290 300 310
350 360 370 380 390 400
pF1KE1 RILCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEQ
:.::::::::::::::::::::::::::::::::::::::::::::::::: : ..:
XP_011 RVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLADQWGKLNKQ
320 330 340 350 360 370
410 420 430 440 450 460
pF1KE1 QKERALQPKKQRLVFTDLQRRTLIAIFKENKRPSKEMQVTISQQLGLELNTVSNFFMNAR
.:
XP_011 TSEARHLVTSVLAADSATEVRERSG
380 390 400
494 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 04:29:19 2016 done: Tue Nov 8 04:29:21 2016
Total Scan time: 10.320 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]