Result of FASTA (ccds) for
pFN21AE1857
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1857, 378 aa
1>>>pF1KE1857 378 - 378 aa - 378 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6958+/-0.000799; mu= 14.7276+/- 0.048
mean_var=71.4181+/-14.681, 0's: 0 Z-trim(106.9): 18 B-trim: 0 in 0/51
Lambda= 0.151764
statistics sampled from 9213 (9227) to 9213 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.283), width: 16
Scan time: 2.810
The best scores are: opt bits E(32554)
CCDS45752.1 METTL2A gene_id:339175|Hs108|chr17 ( 378) 2594 577.1 8.7e-165
CCDS5803.2 METTL2B gene_id:55798|Hs108|chr7 ( 378) 2578 573.6 9.9e-164
CCDS2242.2 METTL8 gene_id:79828|Hs108|chr2 ( 407) 1328 299.9 2.6e-81
CCDS82532.1 METTL8 gene_id:79828|Hs108|chr2 ( 291) 820 188.6 5.9e-48
CCDS82531.1 METTL8 gene_id:79828|Hs108|chr2 ( 241) 716 165.8 3.6e-41
CCDS43056.1 METTL6 gene_id:131965|Hs108|chr3 ( 284) 597 139.8 2.9e-33
CCDS77706.1 METTL6 gene_id:131965|Hs108|chr3 ( 239) 425 102.1 5.4e-22
>>CCDS45752.1 METTL2A gene_id:339175|Hs108|chr17 (378 aa)
initn: 2594 init1: 2594 opt: 2594 Z-score: 3071.9 bits: 577.1 E(32554): 8.7e-165
Smith-Waterman score: 2594; 99.7% identity (99.7% similar) in 378 aa overlap (1-378:1-378)
10 20 30 40 50 60
pF1KE1 MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SEVPECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSA
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
CCDS45 SEVPECRNNEDGPGLIMEEQHKCSSKSLEHKTQTLPVEENVTQKISDLEICADEFPGSSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 CDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 CDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTM
310 320 330 340 350 360
370
pF1KE1 YRVWIQCKYCKPLLSSTS
::::::::::::::::::
CCDS45 YRVWIQCKYCKPLLSSTS
370
>>CCDS5803.2 METTL2B gene_id:55798|Hs108|chr7 (378 aa)
initn: 2578 init1: 2578 opt: 2578 Z-score: 3053.0 bits: 573.6 E(32554): 9.9e-164
Smith-Waterman score: 2578; 98.7% identity (99.5% similar) in 378 aa overlap (1-378:1-378)
10 20 30 40 50 60
pF1KE1 MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ
:::::::::::.::::::::::::: ::::::::::::::::::::::::::::::::::
CCDS58 MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SEVPECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSA
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 SEVCECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 CDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQ
:::::::::::::::::::::::::.:::::::::::::::::::::.::::::::::::
CCDS58 CDEEKSYPVPKGSLDIIILIFVLSAVVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTM
310 320 330 340 350 360
370
pF1KE1 YRVWIQCKYCKPLLSSTS
::::::::::::::::::
CCDS58 YRVWIQCKYCKPLLSSTS
370
>>CCDS2242.2 METTL8 gene_id:79828|Hs108|chr2 (407 aa)
initn: 1317 init1: 797 opt: 1328 Z-score: 1573.3 bits: 299.9 E(32554): 2.6e-81
Smith-Waterman score: 1328; 55.4% identity (78.1% similar) in 361 aa overlap (20-373:31-390)
10 20 30 40
pF1KE1 MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAA
.:::.: :::.::.:: ::...::.:. ::
CCDS22 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 AERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQ
:..::.::: :: :.:: :: .: :::. :::::.: :::::.::. ::::. : ...
CCDS22 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 NHLK----DWFLENKSEVPECRNNEDGPGLIMEEQH-KCSSKSLEHKTQTPPVEENV-TQ
. : .: . :. . . . : . :..: . :: : : ...: :. ..
CCDS22 PEEKARESSW-DHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSE
130 140 150 160 170
170 180 190 200 210 220
pF1KE1 KISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQT-NNDPGLFVYCCDFSSTAIELV
: . . . ::::.::.::::::::.::.:::::.: .:.: :.:::::.: :.:::
CCDS22 KHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELV
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE1 QTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLL
...: : ..:::::::.::. :: : : ::.:.:.::::.: ::.:: ..::::.::
CCDS22 KSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE1 KPGGMMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKV
:::::.:.::::::: .:::::::.::: ::::::::::.::::. :. ..: :.:..
CCDS22 KPGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEK
300 310 320 330 340 350
350 360 370
pF1KE1 QNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS
:::::::::::: ::. :.::::: :. :::
CCDS22 QNLVDRRLQVNRKKQVKMHRVWIQGKFQKPLHQTQNSSNMVSTLLSQD
360 370 380 390 400
>>CCDS82532.1 METTL8 gene_id:79828|Hs108|chr2 (291 aa)
initn: 800 init1: 390 opt: 820 Z-score: 974.5 bits: 188.6 E(32554): 5.9e-48
Smith-Waterman score: 820; 49.2% identity (74.0% similar) in 258 aa overlap (20-270:31-287)
10 20 30 40
pF1KE1 MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAA
.:::.: :::.::.:: ::...::.:. ::
CCDS82 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 AERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQ
:..::.::: :: :.:: :: .: :::. :::::.: :::::.::. ::::. : ...
CCDS82 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 NHLK----DWFLENKSEVPECRNNEDGPGLIMEEQH-KCSSKSLEHKTQTPPVEENV-TQ
. : .: . :. . . . : . :..: . :: : : ...: :. ..
CCDS82 PEEKARESSW-DHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSE
130 140 150 160 170
170 180 190 200 210 220
pF1KE1 KISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQT-NNDPGLFVYCCDFSSTAIELV
: . . . ::::.::.::::::::.::.:::::.: .:.: :.:::::.: :.:::
CCDS82 KHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELV
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE1 QTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLL
...: : ..:::::::.::. :: : : ::.:.:.::::.: ::.
CCDS82 KSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRTLFI
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE1 KPGGMMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKV
>>CCDS82531.1 METTL8 gene_id:79828|Hs108|chr2 (241 aa)
initn: 694 init1: 284 opt: 716 Z-score: 852.7 bits: 165.8 E(32554): 3.6e-41
Smith-Waterman score: 716; 47.9% identity (72.7% similar) in 238 aa overlap (40-270:1-237)
10 20 30 40 50 60
pF1KE1 PAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVD
..::.:. :::..::.::: :: :.::
CCDS82 MQWSKEEEAAARKKVKENSAVRVLLEEQVK
10 20 30
70 80 90 100 110 120
pF1KE1 YEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLK----DWFLENKSEVPE
:: .: :::. :::::.: :::::.::. ::::. : ... . : .: . :. . .
CCDS82 YEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSW-DHVKTSATN
40 50 60 70 80
130 140 150 160 170 180
pF1KE1 CRNNEDGPGLIMEEQH-KCSSKSLEHKTQTPPVEENV-TQKISDLEICADEFPGSSATYR
. : . :..: . :: : : ...: :. ..: . . . ::::.::.:
CCDS82 RFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFR
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE1 ILEVGCGVGNTVFPILQT-NNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCD
:::::::.::.:::::.: .:.: :.:::::.: :.:::...: : ..:::::::.::
CCDS82 ILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCD
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE1 EEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQLR
. :: : : ::.:.:.::::.: ::.
CCDS82 DGLPYPFPDGILDVILLVFVLSSIHPDRTLFI
210 220 230 240
>>CCDS43056.1 METTL6 gene_id:131965|Hs108|chr3 (284 aa)
initn: 633 init1: 512 opt: 597 Z-score: 710.8 bits: 139.8 E(32554): 2.9e-33
Smith-Waterman score: 603; 38.2% identity (56.2% similar) in 322 aa overlap (51-372:19-269)
30 40 50 60 70 80
pF1KE1 GSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDYEINAHKYWND
:.:..... : . :: : .:.: :.
CCDS43 MASLQRKGLQARILTSEEEEKLKRDQTL-VSDFKQQKLEQEAQKNWDL
10 20 30 40
90 100 110 120 130 140
pF1KE1 FYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVPECRNNEDGPGLIMEEQ
::: . ..::::::: :: :: .: ::. ::
CCDS43 FYKRNSTNFFKDRHWTTREFEEL----------------RS----CREFED---------
50 60 70
150 160 170 180 190 200
pF1KE1 HKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQ
::.. .::.:::::: .::.:.
CCDS43 ----------------------QKLT-----------------MLEAGCGVGNCLFPLLE
80 90
210 220 230 240 250 260
pF1KE1 TNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILI
.::..:.: :::: ::: :. : :: :: .: :: .. :: :.:...::
CCDS43 --EDPNIFAYACDFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLI
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE1 FVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGT
:::::. ::::. ... . ..:::: .:.:::: :: :.:::: .. :. ::::: :::
CCDS43 FVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGT
160 170 180 190 200 210
330 340 350 360 370
pF1KE1 RVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS
: ::::.. : :: .: :.: : : ::. . : . ::..: :. ::
CCDS43 RSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVV
220 230 240 250 260 270
CCDS43 LGLDPKS
280
>>CCDS77706.1 METTL6 gene_id:131965|Hs108|chr3 (239 aa)
initn: 425 init1: 425 opt: 425 Z-score: 508.4 bits: 102.1 E(32554): 5.4e-22
Smith-Waterman score: 425; 46.7% identity (68.0% similar) in 150 aa overlap (223-372:75-224)
200 210 220 230 240 250
pF1KE1 NTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKG
. : :: :: .: :: .. ::
CCDS77 WDLFYKRNSTNFFKDRHWTTREFEELRSCREQNPLYDTERCKVFQCDLTKDDLLDHVPPE
50 60 70 80 90 100
260 270 280 290 300 310
pF1KE1 SLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQLRFKKGQCLSGN
:.:...:::::::. ::::. ... . ..:::: .:.:::: :: :.:::: .. :. :
CCDS77 SVDVVMLIFVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGEN
110 120 130 140 150 160
320 330 340 350 360 370
pF1KE1 FYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKP
:::: :::: ::::.. : :: .: :.: : : ::. . : . ::..: :. ::
CCDS77 FYVRQDGTRSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQSKFLKP
170 180 190 200 210 220
pF1KE1 LLSSTS
CCDS77 PKNPSPVVLGLDPKS
230
378 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 10:38:38 2016 done: Sun Nov 6 10:38:38 2016
Total Scan time: 2.810 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]