FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6495, 458 aa 1>>>pF1KE6495 458 - 458 aa - 458 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1748+/-0.000325; mu= 18.7462+/- 0.020 mean_var=73.3065+/-14.942, 0's: 0 Z-trim(116.0): 154 B-trim: 0 in 0/52 Lambda= 0.149797 statistics sampled from 26743 (26916) to 26743 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.677), E-opt: 0.2 (0.316), width: 16 Scan time: 9.830 The best scores are: opt bits E(85289) NP_001094832 (OMIM: 609273,613727) kelch repeat an ( 458) 3111 681.6 1.2e-195 NP_061335 (OMIM: 611201) kelch-like protein 9 [Hom ( 617) 335 81.8 5.9e-15 NP_001003760 (OMIM: 610749) kelch-like protein 31 ( 634) 316 77.7 1e-13 XP_005249164 (OMIM: 610749) PREDICTED: kelch-like ( 634) 316 77.7 1e-13 XP_016866347 (OMIM: 610749) PREDICTED: kelch-like ( 634) 316 77.7 1e-13 NP_001161775 (OMIM: 300655) kelch-like protein 13 ( 613) 313 77.0 1.6e-13 NP_001161773 (OMIM: 300655) kelch-like protein 13 ( 639) 313 77.0 1.6e-13 NP_001161774 (OMIM: 300655) kelch-like protein 13 ( 639) 313 77.0 1.6e-13 XP_016885439 (OMIM: 300655) PREDICTED: kelch-like ( 639) 313 77.0 1.6e-13 NP_001161772 (OMIM: 300655) kelch-like protein 13 ( 649) 313 77.0 1.6e-13 NP_277030 (OMIM: 300655) kelch-like protein 13 iso ( 655) 313 77.0 1.7e-13 XP_011529713 (OMIM: 300655) PREDICTED: kelch-like ( 655) 313 77.0 1.7e-13 NP_001161771 (OMIM: 300655) kelch-like protein 13 ( 658) 313 77.0 1.7e-13 XP_011529711 (OMIM: 300655) PREDICTED: kelch-like ( 661) 313 77.0 1.7e-13 XP_011529712 (OMIM: 300655) PREDICTED: kelch-like ( 661) 313 77.0 1.7e-13 NP_001165125 (OMIM: 608064) kelch-like protein 5 i ( 568) 310 76.3 2.3e-13 NP_950240 (OMIM: 608064) kelch-like protein 5 isof ( 694) 310 76.4 2.7e-13 NP_001007076 (OMIM: 608064) kelch-like protein 5 i ( 709) 310 76.4 2.8e-13 NP_057074 (OMIM: 608064) kelch-like protein 5 isof ( 755) 310 76.4 2.9e-13 XP_011512003 (OMIM: 608064) PREDICTED: kelch-like ( 788) 310 76.4 3e-13 XP_016863764 (OMIM: 608064) PREDICTED: kelch-like ( 788) 310 76.4 3e-13 XP_016863765 (OMIM: 608064) PREDICTED: kelch-like ( 788) 310 76.4 3e-13 XP_011512002 (OMIM: 608064) PREDICTED: kelch-like ( 788) 310 76.4 3e-13 XP_005262712 (OMIM: 608064) PREDICTED: kelch-like ( 789) 310 76.4 3e-13 XP_016863763 (OMIM: 608064) PREDICTED: kelch-like ( 804) 310 76.4 3e-13 XP_011512001 (OMIM: 608064) PREDICTED: kelch-like ( 804) 310 76.4 3e-13 XP_016863762 (OMIM: 608064) PREDICTED: kelch-like ( 804) 310 76.4 3e-13 XP_005244900 (OMIM: 609209) PREDICTED: influenza v ( 424) 267 66.9 1.2e-10 XP_016855573 (OMIM: 609209) PREDICTED: influenza v ( 431) 267 67.0 1.2e-10 XP_011507382 (OMIM: 609209) PREDICTED: influenza v ( 560) 267 67.0 1.4e-10 NP_006460 (OMIM: 609209) influenza virus NS1A-bind ( 642) 267 67.1 1.6e-10 XP_011507381 (OMIM: 609209) PREDICTED: influenza v ( 649) 267 67.1 1.6e-10 XP_016876168 (OMIM: 605332) PREDICTED: kelch-like ( 525) 263 66.2 2.5e-10 XP_016876167 (OMIM: 605332) PREDICTED: kelch-like ( 575) 263 66.2 2.7e-10 NP_001278936 (OMIM: 611967) kelch-like protein 8 i ( 437) 261 65.7 2.9e-10 NP_001273654 (OMIM: 605332) kelch-like protein 1 i ( 687) 263 66.2 3.1e-10 NP_065917 (OMIM: 605332) kelch-like protein 1 isof ( 748) 263 66.3 3.3e-10 NP_001278935 (OMIM: 611967) kelch-like protein 8 i ( 544) 261 65.7 3.5e-10 NP_065854 (OMIM: 611967) kelch-like protein 8 isof ( 620) 261 65.8 3.8e-10 NP_001278932 (OMIM: 611967) kelch-like protein 8 i ( 620) 261 65.8 3.8e-10 NP_065856 (OMIM: 613772) kelch-like protein 14 [Ho ( 628) 260 65.6 4.5e-10 NP_061990 (OMIM: 300348) kelch-like protein 4 isof ( 718) 243 61.9 6.4e-09 NP_476503 (OMIM: 300348) kelch-like protein 4 isof ( 720) 243 61.9 6.4e-09 XP_016862151 (OMIM: 611295) PREDICTED: kelch-like ( 319) 231 59.1 2.1e-08 XP_016862152 (OMIM: 611295) PREDICTED: kelch-like ( 319) 231 59.1 2.1e-08 NP_001311238 (OMIM: 616262) kelch-like protein 21 ( 500) 231 59.2 2.9e-08 NP_055666 (OMIM: 616262) kelch-like protein 21 iso ( 597) 231 59.3 3.3e-08 XP_005247611 (OMIM: 611295) PREDICTED: kelch-like ( 600) 231 59.3 3.3e-08 XP_011511240 (OMIM: 611295) PREDICTED: kelch-like ( 600) 231 59.3 3.3e-08 XP_005247609 (OMIM: 611295) PREDICTED: kelch-like ( 600) 231 59.3 3.3e-08 >>NP_001094832 (OMIM: 609273,613727) kelch repeat and BT (458 aa) initn: 3111 init1: 3111 opt: 3111 Z-score: 3633.6 bits: 681.6 E(85289): 1.2e-195 Smith-Waterman score: 3111; 99.8% identity (100.0% similar) in 458 aa overlap (1-458:1-458) 10 20 30 40 50 60 pF1KE6 MARGPQTLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MARGPQTLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 TLQVLRGDRPALAAEDELLQVVECAAFLQAPALARFLEHNLTSDNCALLCDAAAAFGLRD ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: NP_001 TLQVLRGDRPALAAEDELLQAVECAAFLQAPALARFLEHNLTSDNCALLCDAAAAFGLRD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 VFHSAALFICDGERELAAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VFHSAALFICDGERELAAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 FPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 AQACGRLFVCLWRPADTTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQACGRLFVCLWRPADTTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 SDDFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDDFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGT 370 380 390 400 410 420 430 440 450 pF1KE6 WRLLREKAGFPRPGSLQTFLLRLPPGAPGPVTSTTAEL :::::::::::::::::::::::::::::::::::::: NP_001 WRLLREKAGFPRPGSLQTFLLRLPPGAPGPVTSTTAEL 430 440 450 >>NP_061335 (OMIM: 611201) kelch-like protein 9 [Homo sa (617 aa) initn: 324 init1: 153 opt: 335 Z-score: 389.5 bits: 81.8 E(85289): 5.9e-15 Smith-Waterman score: 339; 28.3% identity (53.1% similar) in 339 aa overlap (148-456:281-612) 120 130 140 150 160 170 pF1KE6 LRDVFHSAALFICDGERELAAELALPEARAYVAALRPSSYAAV---STH-TPAPGFLED- :. . :. .:. ::: . : :.. NP_061 INYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQ 260 270 280 290 300 310 180 190 200 210 220 pF1KE6 --ASRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRG---ASKEVVEL .:. : . ::. . ::.:: :..: :.:..:: ::.::: . .: .:. NP_061 LVVSKELRMYDERAQEWRSLA--PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDT 320 330 340 350 360 230 240 250 260 270 280 pF1KE6 GFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSF : .:: . : . : .. : :... :.:::.::. ...:: :.: . ::. NP_061 VFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSY 370 380 390 400 410 420 290 300 310 320 330 340 pF1KE6 VADLPQPAAGVPCAQACGRLFVCLWRPADT--TAVVEYAVRTDAWLPVAELRRPQSYGHC :: . .: : . : ... :: . .. . :: :. : . .. :: NP_061 VAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGL-HC 430 440 450 460 470 480 350 360 370 380 390 pF1KE6 MVAHRDSLYVVRN----GPSD--DFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVR : . :.:::. . : :: : : : .: ::: . ... ... . .:: . NP_061 MCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTL--DQWTPIAAML-RGQSDVGVAVFE 490 500 510 520 530 540 400 410 420 430 440 pF1KE6 GDTVYTV------NR-MFTLL--YAIEGGTWRL---LREKAGFPRPGSLQTFLLRLPPGA . .:.: :: : .. : : :. : :. : : .: .: . ::. NP_061 -NKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEENPGS 550 560 570 580 590 600 450 pF1KE6 PGPVTSTTAEL :. . .: NP_061 PSRESPLSAPSDHS 610 >>NP_001003760 (OMIM: 610749) kelch-like protein 31 [Hom (634 aa) initn: 250 init1: 124 opt: 316 Z-score: 367.2 bits: 77.7 E(85289): 1e-13 Smith-Waterman score: 316; 30.8% identity (57.1% similar) in 247 aa overlap (167-391:325-559) 140 150 160 170 180 190 pF1KE6 AAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDA-SRTLCYLDEEEDAWRTLAALPL ::. : . :: . : : : ..: :. .: NP_001 HLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPE-NGWSKLTEMP- 300 310 320 330 340 350 200 210 220 230 240 pF1KE6 EASTLLAGVATLGNKLYIVGG-----VRGASKEVVELGFC-YDPDGGTWHEFPSPHQPRY :... ::.. . ::..:: .:. .:..: .:: ::: .:: .. : .: : NP_001 -AKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVS-NFCRYDPRFNTWIHLASMNQKRT 360 370 380 390 400 410 250 260 270 280 290 300 pF1KE6 DTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQAC----- .:. :.: .:: ::. . ..:.: : :... : :: . . :. : NP_001 HFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQW-------QPKTPLEVARCCHASAV 420 430 440 450 460 310 320 330 340 350 pF1KE6 --GRLFVCLWRPAD--TTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN-- ::..: :. . .: : .:.: . .: :... :: :. : .::. . NP_001 ADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGW-HCAVTLSDRVYVMGGSQ 470 480 490 500 510 520 360 370 380 390 400 410 pF1KE6 -GPSDDFLHC-AIDCLNLATGQWT-ALPGQF-VNSKGALFTAVVRGDTVYTVNRMFTLLY :: . . ...: . :::::. : : : :.. : NP_001 LGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKK 530 540 550 560 570 580 420 430 440 450 pF1KE6 AIEGGTWRLLREKAGFPRPGSLQTFLLRLPPGAPGPVTSTTAEL NP_001 CIQCFSPELNEWTEDDELPEATVGVSCCTLSMPNNVTRESRASSVSSVPVSI 590 600 610 620 630 >>XP_005249164 (OMIM: 610749) PREDICTED: kelch-like prot (634 aa) initn: 250 init1: 124 opt: 316 Z-score: 367.2 bits: 77.7 E(85289): 1e-13 Smith-Waterman score: 316; 30.8% identity (57.1% similar) in 247 aa overlap (167-391:325-559) 140 150 160 170 180 190 pF1KE6 AAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDA-SRTLCYLDEEEDAWRTLAALPL ::. : . :: . : : : ..: :. .: XP_005 HLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPE-NGWSKLTEMP- 300 310 320 330 340 350 200 210 220 230 240 pF1KE6 EASTLLAGVATLGNKLYIVGG-----VRGASKEVVELGFC-YDPDGGTWHEFPSPHQPRY :... ::.. . ::..:: .:. .:..: .:: ::: .:: .. : .: : XP_005 -AKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVS-NFCRYDPRFNTWIHLASMNQKRT 360 370 380 390 400 410 250 260 270 280 290 300 pF1KE6 DTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQAC----- .:. :.: .:: ::. . ..:.: : :... : :: . . :. : XP_005 HFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQW-------QPKTPLEVARCCHASAV 420 430 440 450 460 310 320 330 340 350 pF1KE6 --GRLFVCLWRPAD--TTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN-- ::..: :. . .: : .:.: . .: :... :: :. : .::. . XP_005 ADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGW-HCAVTLSDRVYVMGGSQ 470 480 490 500 510 520 360 370 380 390 400 410 pF1KE6 -GPSDDFLHC-AIDCLNLATGQWT-ALPGQF-VNSKGALFTAVVRGDTVYTVNRMFTLLY :: . . ...: . :::::. : : : :.. : XP_005 LGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKK 530 540 550 560 570 580 420 430 440 450 pF1KE6 AIEGGTWRLLREKAGFPRPGSLQTFLLRLPPGAPGPVTSTTAEL XP_005 CIQCFSPELNEWTEDDELPEATVGVSCCTLSMPNNVTRESRASSVSSVPVSI 590 600 610 620 630 >>XP_016866347 (OMIM: 610749) PREDICTED: kelch-like prot (634 aa) initn: 250 init1: 124 opt: 316 Z-score: 367.2 bits: 77.7 E(85289): 1e-13 Smith-Waterman score: 316; 30.8% identity (57.1% similar) in 247 aa overlap (167-391:325-559) 140 150 160 170 180 190 pF1KE6 AAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDA-SRTLCYLDEEEDAWRTLAALPL ::. : . :: . : : : ..: :. .: XP_016 HLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPE-NGWSKLTEMP- 300 310 320 330 340 350 200 210 220 230 240 pF1KE6 EASTLLAGVATLGNKLYIVGG-----VRGASKEVVELGFC-YDPDGGTWHEFPSPHQPRY :... ::.. . ::..:: .:. .:..: .:: ::: .:: .. : .: : XP_016 -AKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVS-NFCRYDPRFNTWIHLASMNQKRT 360 370 380 390 400 410 250 260 270 280 290 300 pF1KE6 DTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQAC----- .:. :.: .:: ::. . ..:.: : :... : :: . . :. : XP_016 HFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQW-------QPKTPLEVARCCHASAV 420 430 440 450 460 310 320 330 340 350 pF1KE6 --GRLFVCLWRPAD--TTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN-- ::..: :. . .: : .:.: . .: :... :: :. : .::. . XP_016 ADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGW-HCAVTLSDRVYVMGGSQ 470 480 490 500 510 520 360 370 380 390 400 410 pF1KE6 -GPSDDFLHC-AIDCLNLATGQWT-ALPGQF-VNSKGALFTAVVRGDTVYTVNRMFTLLY :: . . ...: . :::::. : : : :.. : XP_016 LGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKK 530 540 550 560 570 580 420 430 440 450 pF1KE6 AIEGGTWRLLREKAGFPRPGSLQTFLLRLPPGAPGPVTSTTAEL XP_016 CIQCFSPELNEWTEDDELPEATVGVSCCTLSMPNNVTRESRASSVSSVPVSI 590 600 610 620 630 >>NP_001161775 (OMIM: 300655) kelch-like protein 13 isof (613 aa) initn: 289 init1: 147 opt: 313 Z-score: 363.9 bits: 77.0 E(85289): 1.6e-13 Smith-Waterman score: 313; 27.4% identity (51.7% similar) in 259 aa overlap (174-421:314-555) 150 160 170 180 190 200 pF1KE6 EARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAG :. : . ::. :..:: :..: : NP_001 PVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLA--PMDAPRYQHG 290 300 310 320 330 340 210 220 230 240 250 260 pF1KE6 VATLGNKLYIVGGVRG---ASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRL .:..:: ::.::: . .: .:. : .:: . : . : .. : :... : : NP_001 IAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYL 350 360 370 380 390 400 270 280 290 300 310 pF1KE6 YAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT--T ::.::. . .:: :.: .. :..:: . .: : . : ... :: NP_001 YAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQK 410 420 430 440 450 460 320 330 340 350 360 370 pF1KE6 AVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN----GPSD--DFLHCAIDCL .. . :: :. : . .. ::: . . :::. . : :: : : : . NP_001 ELMCFDPDTDKWIQKAPMTTVRGL-HCMCTVGERLYVIGGNHFRGTSDYDDVLSC--EYY 470 480 490 500 510 380 390 400 410 420 430 pF1KE6 NLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGTWRLLREKAGFPR . ::: . .:..::.. : . . .:.. : .: NP_001 SPILDQWTPI------------AAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQK 520 530 540 550 560 440 450 pF1KE6 PGSLQTFLLRLPPGAPGPVTSTTAEL NP_001 YDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 570 580 590 600 610 >>NP_001161773 (OMIM: 300655) kelch-like protein 13 isof (639 aa) initn: 289 init1: 147 opt: 313 Z-score: 363.6 bits: 77.0 E(85289): 1.6e-13 Smith-Waterman score: 313; 27.4% identity (51.7% similar) in 259 aa overlap (174-421:340-581) 150 160 170 180 190 200 pF1KE6 EARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAG :. : . ::. :..:: :..: : NP_001 PVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLA--PMDAPRYQHG 310 320 330 340 350 360 210 220 230 240 250 260 pF1KE6 VATLGNKLYIVGGVRG---ASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRL .:..:: ::.::: . .: .:. : .:: . : . : .. : :... : : NP_001 IAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYL 370 380 390 400 410 420 270 280 290 300 310 pF1KE6 YAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT--T ::.::. . .:: :.: .. :..:: . .: : . : ... :: NP_001 YAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQK 430 440 450 460 470 480 320 330 340 350 360 370 pF1KE6 AVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN----GPSD--DFLHCAIDCL .. . :: :. : . .. ::: . . :::. . : :: : : : . NP_001 ELMCFDPDTDKWIQKAPMTTVRGL-HCMCTVGERLYVIGGNHFRGTSDYDDVLSC--EYY 490 500 510 520 530 540 380 390 400 410 420 430 pF1KE6 NLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGTWRLLREKAGFPR . ::: . .:..::.. : . . .:.. : .: NP_001 SPILDQWTPI------------AAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQK 550 560 570 580 590 440 450 pF1KE6 PGSLQTFLLRLPPGAPGPVTSTTAEL NP_001 YDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 600 610 620 630 >>NP_001161774 (OMIM: 300655) kelch-like protein 13 isof (639 aa) initn: 289 init1: 147 opt: 313 Z-score: 363.6 bits: 77.0 E(85289): 1.6e-13 Smith-Waterman score: 313; 27.4% identity (51.7% similar) in 259 aa overlap (174-421:340-581) 150 160 170 180 190 200 pF1KE6 EARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAG :. : . ::. :..:: :..: : NP_001 PVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLA--PMDAPRYQHG 310 320 330 340 350 360 210 220 230 240 250 260 pF1KE6 VATLGNKLYIVGGVRG---ASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRL .:..:: ::.::: . .: .:. : .:: . : . : .. : :... : : NP_001 IAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYL 370 380 390 400 410 420 270 280 290 300 310 pF1KE6 YAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT--T ::.::. . .:: :.: .. :..:: . .: : . : ... :: NP_001 YAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQK 430 440 450 460 470 480 320 330 340 350 360 370 pF1KE6 AVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN----GPSD--DFLHCAIDCL .. . :: :. : . .. ::: . . :::. . : :: : : : . NP_001 ELMCFDPDTDKWIQKAPMTTVRGL-HCMCTVGERLYVIGGNHFRGTSDYDDVLSC--EYY 490 500 510 520 530 540 380 390 400 410 420 430 pF1KE6 NLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGTWRLLREKAGFPR . ::: . .:..::.. : . . .:.. : .: NP_001 SPILDQWTPI------------AAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQK 550 560 570 580 590 440 450 pF1KE6 PGSLQTFLLRLPPGAPGPVTSTTAEL NP_001 YDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 600 610 620 630 >>XP_016885439 (OMIM: 300655) PREDICTED: kelch-like prot (639 aa) initn: 289 init1: 147 opt: 313 Z-score: 363.6 bits: 77.0 E(85289): 1.6e-13 Smith-Waterman score: 313; 27.4% identity (51.7% similar) in 259 aa overlap (174-421:340-581) 150 160 170 180 190 200 pF1KE6 EARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAG :. : . ::. :..:: :..: : XP_016 PVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLA--PMDAPRYQHG 310 320 330 340 350 360 210 220 230 240 250 260 pF1KE6 VATLGNKLYIVGGVRG---ASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRL .:..:: ::.::: . .: .:. : .:: . : . : .. : :... : : XP_016 IAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYL 370 380 390 400 410 420 270 280 290 300 310 pF1KE6 YAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT--T ::.::. . .:: :.: .. :..:: . .: : . : ... :: XP_016 YAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQK 430 440 450 460 470 480 320 330 340 350 360 370 pF1KE6 AVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN----GPSD--DFLHCAIDCL .. . :: :. : . .. ::: . . :::. . : :: : : : . XP_016 ELMCFDPDTDKWIQKAPMTTVRGL-HCMCTVGERLYVIGGNHFRGTSDYDDVLSC--EYY 490 500 510 520 530 540 380 390 400 410 420 430 pF1KE6 NLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGTWRLLREKAGFPR . ::: . .:..::.. : . . .:.. : .: XP_016 SPILDQWTPI------------AAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQK 550 560 570 580 590 440 450 pF1KE6 PGSLQTFLLRLPPGAPGPVTSTTAEL XP_016 YDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 600 610 620 630 >>NP_001161772 (OMIM: 300655) kelch-like protein 13 isof (649 aa) initn: 289 init1: 147 opt: 313 Z-score: 363.5 bits: 77.0 E(85289): 1.6e-13 Smith-Waterman score: 313; 27.4% identity (51.7% similar) in 259 aa overlap (174-421:350-591) 150 160 170 180 190 200 pF1KE6 EARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAG :. : . ::. :..:: :..: : NP_001 PVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLA--PMDAPRYQHG 320 330 340 350 360 370 210 220 230 240 250 260 pF1KE6 VATLGNKLYIVGGVRG---ASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRL .:..:: ::.::: . .: .:. : .:: . : . : .. : :... : : NP_001 IAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYL 380 390 400 410 420 430 270 280 290 300 310 pF1KE6 YAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT--T ::.::. . .:: :.: .. :..:: . .: : . : ... :: NP_001 YAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQK 440 450 460 470 480 490 320 330 340 350 360 370 pF1KE6 AVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN----GPSD--DFLHCAIDCL .. . :: :. : . .. ::: . . :::. . : :: : : : . NP_001 ELMCFDPDTDKWIQKAPMTTVRGL-HCMCTVGERLYVIGGNHFRGTSDYDDVLSC--EYY 500 510 520 530 540 550 380 390 400 410 420 430 pF1KE6 NLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGTWRLLREKAGFPR . ::: . .:..::.. : . . .:.. : .: NP_001 SPILDQWTPI------------AAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQK 560 570 580 590 600 440 450 pF1KE6 PGSLQTFLLRLPPGAPGPVTSTTAEL NP_001 YDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 610 620 630 640 458 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:52:17 2016 done: Tue Nov 8 13:52:18 2016 Total Scan time: 9.830 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]