FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6397, 223 aa 1>>>pF1KE6397 223 - 223 aa - 223 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.6535+/-0.000338; mu= -5.2680+/- 0.021 mean_var=224.8273+/-46.557, 0's: 0 Z-trim(122.6): 7 B-trim: 0 in 0/57 Lambda= 0.085536 statistics sampled from 40999 (41006) to 40999 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.803), E-opt: 0.2 (0.481), width: 16 Scan time: 4.770 The best scores are: opt bits E(85289) XP_005250568 (OMIM: 615203) PREDICTED: rhomboid do ( 223) 1525 199.9 2.9e-51 NP_001333116 (OMIM: 615203) rhomboid domain-contai ( 223) 1525 199.9 2.9e-51 NP_001333115 (OMIM: 615203) rhomboid domain-contai ( 223) 1525 199.9 2.9e-51 NP_001035547 (OMIM: 615203) rhomboid domain-contai ( 223) 1525 199.9 2.9e-51 NP_001035546 (OMIM: 615203) rhomboid domain-contai ( 364) 1525 200.0 4.3e-51 NP_001333117 (OMIM: 615203) rhomboid domain-contai ( 228) 1165 155.5 6.9e-38 NP_001333118 (OMIM: 615203) rhomboid domain-contai ( 216) 1090 146.2 4e-35 >>XP_005250568 (OMIM: 615203) PREDICTED: rhomboid domain (223 aa) initn: 1525 init1: 1525 opt: 1525 Z-score: 1041.5 bits: 199.9 E(85289): 2.9e-51 Smith-Waterman score: 1525; 100.0% identity (100.0% similar) in 223 aa overlap (1-223:1-223) 10 20 30 40 50 60 pF1KE6 MLGVTTVRSRMRRALVFGMVVPSVLVPWLLLGASWLIPQTSFLSNVCGLSIGLAYGLTYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLGVTTVRSRMRRALVFGMVVPSVLVPWLLLGASWLIPQTSFLSNVCGLSIGLAYGLTYC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 YSIDLSERVALKLDQTFPFSLMRRISVFKYVSGSSAERRAAQSRKLNPVPGSYPTQSCHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YSIDLSERVALKLDQTFPFSLMRRISVFKYVSGSSAERRAAQSRKLNPVPGSYPTQSCHP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 HLSPSHPVSQTQHASGQKLASWPSCTPGHMPTLPPYQPASGLCYVQNHFGPNPTSSSVYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HLSPSHPVSQTQHASGQKLASWPSCTPGHMPTLPPYQPASGLCYVQNHFGPNPTSSSVYP 130 140 150 160 170 180 190 200 210 220 pF1KE6 ASAGTSLGIQPPTPVNSPGTVYSGALGTPGAAGSKESSRVPMP ::::::::::::::::::::::::::::::::::::::::::: XP_005 ASAGTSLGIQPPTPVNSPGTVYSGALGTPGAAGSKESSRVPMP 190 200 210 220 >>NP_001333116 (OMIM: 615203) rhomboid domain-containing (223 aa) initn: 1525 init1: 1525 opt: 1525 Z-score: 1041.5 bits: 199.9 E(85289): 2.9e-51 Smith-Waterman score: 1525; 100.0% identity (100.0% similar) in 223 aa overlap (1-223:1-223) 10 20 30 40 50 60 pF1KE6 MLGVTTVRSRMRRALVFGMVVPSVLVPWLLLGASWLIPQTSFLSNVCGLSIGLAYGLTYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLGVTTVRSRMRRALVFGMVVPSVLVPWLLLGASWLIPQTSFLSNVCGLSIGLAYGLTYC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 YSIDLSERVALKLDQTFPFSLMRRISVFKYVSGSSAERRAAQSRKLNPVPGSYPTQSCHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YSIDLSERVALKLDQTFPFSLMRRISVFKYVSGSSAERRAAQSRKLNPVPGSYPTQSCHP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 HLSPSHPVSQTQHASGQKLASWPSCTPGHMPTLPPYQPASGLCYVQNHFGPNPTSSSVYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLSPSHPVSQTQHASGQKLASWPSCTPGHMPTLPPYQPASGLCYVQNHFGPNPTSSSVYP 130 140 150 160 170 180 190 200 210 220 pF1KE6 ASAGTSLGIQPPTPVNSPGTVYSGALGTPGAAGSKESSRVPMP ::::::::::::::::::::::::::::::::::::::::::: NP_001 ASAGTSLGIQPPTPVNSPGTVYSGALGTPGAAGSKESSRVPMP 190 200 210 220 >>NP_001333115 (OMIM: 615203) rhomboid domain-containing (223 aa) initn: 1525 init1: 1525 opt: 1525 Z-score: 1041.5 bits: 199.9 E(85289): 2.9e-51 Smith-Waterman score: 1525; 100.0% identity (100.0% similar) in 223 aa overlap (1-223:1-223) 10 20 30 40 50 60 pF1KE6 MLGVTTVRSRMRRALVFGMVVPSVLVPWLLLGASWLIPQTSFLSNVCGLSIGLAYGLTYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLGVTTVRSRMRRALVFGMVVPSVLVPWLLLGASWLIPQTSFLSNVCGLSIGLAYGLTYC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 YSIDLSERVALKLDQTFPFSLMRRISVFKYVSGSSAERRAAQSRKLNPVPGSYPTQSCHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YSIDLSERVALKLDQTFPFSLMRRISVFKYVSGSSAERRAAQSRKLNPVPGSYPTQSCHP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 HLSPSHPVSQTQHASGQKLASWPSCTPGHMPTLPPYQPASGLCYVQNHFGPNPTSSSVYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLSPSHPVSQTQHASGQKLASWPSCTPGHMPTLPPYQPASGLCYVQNHFGPNPTSSSVYP 130 140 150 160 170 180 190 200 210 220 pF1KE6 ASAGTSLGIQPPTPVNSPGTVYSGALGTPGAAGSKESSRVPMP ::::::::::::::::::::::::::::::::::::::::::: NP_001 ASAGTSLGIQPPTPVNSPGTVYSGALGTPGAAGSKESSRVPMP 190 200 210 220 >>NP_001035547 (OMIM: 615203) rhomboid domain-containing (223 aa) initn: 1525 init1: 1525 opt: 1525 Z-score: 1041.5 bits: 199.9 E(85289): 2.9e-51 Smith-Waterman score: 1525; 100.0% identity (100.0% similar) in 223 aa overlap (1-223:1-223) 10 20 30 40 50 60 pF1KE6 MLGVTTVRSRMRRALVFGMVVPSVLVPWLLLGASWLIPQTSFLSNVCGLSIGLAYGLTYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLGVTTVRSRMRRALVFGMVVPSVLVPWLLLGASWLIPQTSFLSNVCGLSIGLAYGLTYC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 YSIDLSERVALKLDQTFPFSLMRRISVFKYVSGSSAERRAAQSRKLNPVPGSYPTQSCHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YSIDLSERVALKLDQTFPFSLMRRISVFKYVSGSSAERRAAQSRKLNPVPGSYPTQSCHP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 HLSPSHPVSQTQHASGQKLASWPSCTPGHMPTLPPYQPASGLCYVQNHFGPNPTSSSVYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLSPSHPVSQTQHASGQKLASWPSCTPGHMPTLPPYQPASGLCYVQNHFGPNPTSSSVYP 130 140 150 160 170 180 190 200 210 220 pF1KE6 ASAGTSLGIQPPTPVNSPGTVYSGALGTPGAAGSKESSRVPMP ::::::::::::::::::::::::::::::::::::::::::: NP_001 ASAGTSLGIQPPTPVNSPGTVYSGALGTPGAAGSKESSRVPMP 190 200 210 220 >>NP_001035546 (OMIM: 615203) rhomboid domain-containing (364 aa) initn: 1525 init1: 1525 opt: 1525 Z-score: 1038.3 bits: 200.0 E(85289): 4.3e-51 Smith-Waterman score: 1525; 100.0% identity (100.0% similar) in 223 aa overlap (1-223:142-364) 10 20 30 pF1KE6 MLGVTTVRSRMRRALVFGMVVPSVLVPWLL :::::::::::::::::::::::::::::: NP_001 IIFLSFEAVSSLSKLGEVEDARGFTPVAFAMLGVTTVRSRMRRALVFGMVVPSVLVPWLL 120 130 140 150 160 170 40 50 60 70 80 90 pF1KE6 LGASWLIPQTSFLSNVCGLSIGLAYGLTYCYSIDLSERVALKLDQTFPFSLMRRISVFKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGASWLIPQTSFLSNVCGLSIGLAYGLTYCYSIDLSERVALKLDQTFPFSLMRRISVFKY 180 190 200 210 220 230 100 110 120 130 140 150 pF1KE6 VSGSSAERRAAQSRKLNPVPGSYPTQSCHPHLSPSHPVSQTQHASGQKLASWPSCTPGHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSGSSAERRAAQSRKLNPVPGSYPTQSCHPHLSPSHPVSQTQHASGQKLASWPSCTPGHM 240 250 260 270 280 290 160 170 180 190 200 210 pF1KE6 PTLPPYQPASGLCYVQNHFGPNPTSSSVYPASAGTSLGIQPPTPVNSPGTVYSGALGTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTLPPYQPASGLCYVQNHFGPNPTSSSVYPASAGTSLGIQPPTPVNSPGTVYSGALGTPG 300 310 320 330 340 350 220 pF1KE6 AAGSKESSRVPMP ::::::::::::: NP_001 AAGSKESSRVPMP 360 >>NP_001333117 (OMIM: 615203) rhomboid domain-containing (228 aa) initn: 1165 init1: 1165 opt: 1165 Z-score: 801.2 bits: 155.5 E(85289): 6.9e-38 Smith-Waterman score: 1165; 100.0% identity (100.0% similar) in 168 aa overlap (56-223:61-228) 30 40 50 60 70 80 pF1KE6 VPWLLLGASWLIPQTSFLSNVCGLSIGLAYGLTYCYSIDLSERVALKLDQTFPFSLMRRI :::::::::::::::::::::::::::::: NP_001 VSGPRLFLLQQPLAPSGLTLKSEALRNWQDGLTYCYSIDLSERVALKLDQTFPFSLMRRI 40 50 60 70 80 90 90 100 110 120 130 140 pF1KE6 SVFKYVSGSSAERRAAQSRKLNPVPGSYPTQSCHPHLSPSHPVSQTQHASGQKLASWPSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVFKYVSGSSAERRAAQSRKLNPVPGSYPTQSCHPHLSPSHPVSQTQHASGQKLASWPSC 100 110 120 130 140 150 150 160 170 180 190 200 pF1KE6 TPGHMPTLPPYQPASGLCYVQNHFGPNPTSSSVYPASAGTSLGIQPPTPVNSPGTVYSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPGHMPTLPPYQPASGLCYVQNHFGPNPTSSSVYPASAGTSLGIQPPTPVNSPGTVYSGA 160 170 180 190 200 210 210 220 pF1KE6 LGTPGAAGSKESSRVPMP :::::::::::::::::: NP_001 LGTPGAAGSKESSRVPMP 220 >>NP_001333118 (OMIM: 615203) rhomboid domain-containing (216 aa) initn: 1090 init1: 1090 opt: 1090 Z-score: 751.6 bits: 146.2 E(85289): 4e-35 Smith-Waterman score: 1090; 100.0% identity (100.0% similar) in 157 aa overlap (67-223:60-216) 40 50 60 70 80 90 pF1KE6 IPQTSFLSNVCGLSIGLAYGLTYCYSIDLSERVALKLDQTFPFSLMRRISVFKYVSGSSA :::::::::::::::::::::::::::::: NP_001 LVSGPRLFLLQQPLAPSGLTLKSEALRNWQERVALKLDQTFPFSLMRRISVFKYVSGSSA 30 40 50 60 70 80 100 110 120 130 140 150 pF1KE6 ERRAAQSRKLNPVPGSYPTQSCHPHLSPSHPVSQTQHASGQKLASWPSCTPGHMPTLPPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERRAAQSRKLNPVPGSYPTQSCHPHLSPSHPVSQTQHASGQKLASWPSCTPGHMPTLPPY 90 100 110 120 130 140 160 170 180 190 200 210 pF1KE6 QPASGLCYVQNHFGPNPTSSSVYPASAGTSLGIQPPTPVNSPGTVYSGALGTPGAAGSKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPASGLCYVQNHFGPNPTSSSVYPASAGTSLGIQPPTPVNSPGTVYSGALGTPGAAGSKE 150 160 170 180 190 200 220 pF1KE6 SSRVPMP ::::::: NP_001 SSRVPMP 210 223 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 12:43:12 2016 done: Tue Nov 8 12:43:12 2016 Total Scan time: 4.770 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]