FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3472, 1512 aa 1>>>pF1KE3472 1512 - 1512 aa - 1512 aa Library: /omim/omim.rfq.tfa 62246620 residues in 87639 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.9951+/-0.000538; mu= 1.2804+/- 0.034 mean_var=607.5782+/-134.242, 0's: 0 Z-trim(121.7): 1649 B-trim: 3430 in 2/58 Lambda= 0.052032 statistics sampled from 36819 (39107) to 36819 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.733), E-opt: 0.2 (0.446), width: 16 Scan time: 13.370 The best scores are: opt bits E(87639) NP_005912 (OMIM: 600982,613762) mitogen-activated (1512) 10050 771.4 0 XP_016864973 (OMIM: 600982,613762) PREDICTED: mito (1375) 8987 691.5 1.2e-197 XP_016864974 (OMIM: 600982,613762) PREDICTED: mito (1349) 8974 690.6 2.4e-197 NP_001317360 (OMIM: 602539) mitogen-activated prot ( 622) 716 70.2 6.2e-11 XP_005257433 (OMIM: 602539) PREDICTED: mitogen-act ( 653) 716 70.2 6.3e-11 NP_002392 (OMIM: 602539) mitogen-activated protein ( 626) 714 70.0 6.9e-11 NP_976226 (OMIM: 602539) mitogen-activated protein ( 657) 714 70.1 7e-11 NP_006600 (OMIM: 609487) mitogen-activated protein ( 619) 682 67.6 3.6e-10 XP_011543813 (OMIM: 300820) PREDICTED: mitogen-act ( 748) 583 60.3 6.9e-08 XP_011543812 (OMIM: 300820) PREDICTED: mitogen-act ( 871) 583 60.4 7.6e-08 NP_001288001 (OMIM: 602425) mitogen-activated prot (1604) 587 61.1 8.7e-08 XP_011543810 (OMIM: 300820) PREDICTED: mitogen-act (1295) 583 60.7 9.5e-08 NP_001001671 (OMIM: 300820) mitogen-activated prot (1313) 583 60.7 9.6e-08 XP_011543809 (OMIM: 300820) PREDICTED: mitogen-act (1324) 583 60.7 9.6e-08 NP_001278887 (OMIM: 602425) mitogen-activated prot (1061) 580 60.3 9.9e-08 XP_016866358 (OMIM: 602425) PREDICTED: mitogen-act (1517) 580 60.5 1.2e-07 NP_005913 (OMIM: 602425) mitogen-activated protein (1608) 580 60.6 1.3e-07 XP_005267046 (OMIM: 602425) PREDICTED: mitogen-act (1554) 570 59.8 2.1e-07 NP_006715 (OMIM: 602425) mitogen-activated protein (1558) 570 59.8 2.1e-07 XP_016866366 (OMIM: 602448) PREDICTED: mitogen-act (1181) 564 59.2 2.4e-07 XP_016866365 (OMIM: 602448) PREDICTED: mitogen-act (1191) 564 59.2 2.4e-07 XP_011534141 (OMIM: 602448) PREDICTED: mitogen-act (1286) 564 59.2 2.5e-07 NP_005914 (OMIM: 602448) mitogen-activated protein (1374) 564 59.3 2.6e-07 XP_016866364 (OMIM: 602448) PREDICTED: mitogen-act (1447) 564 59.3 2.7e-07 XP_016866363 (OMIM: 602448) PREDICTED: mitogen-act (1458) 564 59.3 2.7e-07 XP_016866362 (OMIM: 602448) PREDICTED: mitogen-act (1483) 564 59.3 2.8e-07 XP_016866361 (OMIM: 602448) PREDICTED: mitogen-act (1484) 564 59.3 2.8e-07 XP_016866360 (OMIM: 602448) PREDICTED: mitogen-act (1493) 564 59.3 2.8e-07 XP_016866359 (OMIM: 602448) PREDICTED: mitogen-act (1494) 564 59.3 2.8e-07 XP_016858260 (OMIM: 604468) PREDICTED: mitogen-act ( 869) 547 57.7 4.9e-07 NP_001284538 (OMIM: 604468) mitogen-activated prot (1280) 547 57.9 6.1e-07 NP_004663 (OMIM: 604468) mitogen-activated protein (1288) 547 57.9 6.2e-07 NP_004064 (OMIM: 602913) serine/threonine-protein ( 646) 471 51.8 2.2e-05 XP_011538703 (OMIM: 616563) PREDICTED: STE20-like ( 783) 471 51.9 2.4e-05 NP_001291672 (OMIM: 616563) STE20-like serine/thre (1204) 471 52.2 3.1e-05 NP_055535 (OMIM: 616563) STE20-like serine/threoni (1235) 471 52.2 3.1e-05 NP_001257354 (OMIM: 604921) mitogen-activated prot ( 873) 453 50.6 6.6e-05 NP_003609 (OMIM: 604921) mitogen-activated protein ( 894) 453 50.7 6.6e-05 NP_002568 (OMIM: 605022) serine/threonine-protein ( 524) 433 48.8 0.00014 XP_011511172 (OMIM: 605022) PREDICTED: serine/thre ( 524) 433 48.8 0.00014 XP_016861990 (OMIM: 605022) PREDICTED: serine/thre ( 524) 433 48.8 0.00014 NP_005981 (OMIM: 603919) serine/threonine-protein ( 968) 437 49.5 0.00016 NP_001121638 (OMIM: 300142,300558) serine/threonin ( 544) 429 48.6 0.00017 NP_001121639 (OMIM: 300142,300558) serine/threonin ( 544) 429 48.6 0.00017 NP_001311254 (OMIM: 300142,300558) serine/threonin ( 544) 429 48.6 0.00017 NP_001311260 (OMIM: 300142,300558) serine/threonin ( 544) 429 48.6 0.00017 NP_001311263 (OMIM: 300142,300558) serine/threonin ( 544) 429 48.6 0.00017 NP_001311261 (OMIM: 300142,300558) serine/threonin ( 544) 429 48.6 0.00017 XP_016885050 (OMIM: 300142,300558) PREDICTED: seri ( 544) 429 48.6 0.00017 NP_001311259 (OMIM: 300142,300558) serine/threonin ( 544) 429 48.6 0.00017 >>NP_005912 (OMIM: 600982,613762) mitogen-activated prot (1512 aa) initn: 10050 init1: 10050 opt: 10050 Z-score: 4100.3 bits: 771.4 E(87639): 0 Smith-Waterman score: 10050; 100.0% identity (100.0% similar) in 1512 aa overlap (1-1512:1-1512) 10 20 30 40 50 60 pF1KE3 MAAAAGNRASSSGFPGARATSPEAGGGGGALKASSAPAAAAGLLREAGSGGRERADWRRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MAAAAGNRASSSGFPGARATSPEAGGGGGALKASSAPAAAAGLLREAGSGGRERADWRRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 QLRKVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QLRKVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 GAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 EERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 PEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 LSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 RNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFN 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 LTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 ESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 MLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 REILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 REILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 VSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 LSVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LSVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 SPECTVHLEKTGKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SPECTVHLEKTGKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 RPHSQCLNSSPLSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RPHSQCLNSSPLSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQ 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 TQRKFSLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TQRKFSLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNS 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 MTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASM 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE3 PSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQD 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE3 ALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQA 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE3 QDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYN 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE3 LFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDST 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE3 GQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAII 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KE3 EMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSR 1450 1460 1470 1480 1490 1500 1510 pF1KE3 ELLKHPVFRTTW :::::::::::: NP_005 ELLKHPVFRTTW 1510 >>XP_016864973 (OMIM: 600982,613762) PREDICTED: mitogen- (1375 aa) initn: 8987 init1: 8987 opt: 8987 Z-score: 3669.5 bits: 691.5 E(87639): 1.2e-197 Smith-Waterman score: 8987; 100.0% identity (100.0% similar) in 1351 aa overlap (162-1512:25-1375) 140 150 160 170 180 190 pF1KE3 DSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRPEERMIREKLKA :::::::::::::::::::::::::::::: XP_016 MNFCKVVVLSGGEKDHECTSCFCRREMENKETLKGLHKMDDRPEERMIREKLKA 10 20 30 40 50 200 210 220 230 240 250 pF1KE3 TCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASAASPASKGRRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASAASPASKGRRSP 60 70 80 90 100 110 260 270 280 290 300 310 pF1KE3 SPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETNRRVNKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETNRRVNKV 120 130 140 150 160 170 320 330 340 350 360 370 pF1KE3 MRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLFVMLRVFQLEPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLFVMLRVFQLEPS 180 190 200 210 220 230 380 390 400 410 420 430 pF1KE3 DPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSS 240 250 260 270 280 290 440 450 460 470 480 490 pF1KE3 ENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLC 300 310 320 330 340 350 500 510 520 530 540 550 pF1KE3 RSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFNLTHYGTQQIPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFNLTHYGTQQIPP 360 370 380 390 400 410 560 570 580 590 600 610 pF1KE3 AYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGSSG 420 430 440 450 460 470 620 630 640 650 660 670 pF1KE3 SSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLA 480 490 500 510 520 530 680 690 700 710 720 730 pF1KE3 ERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGI 540 550 560 570 580 590 740 750 760 770 780 790 pF1KE3 GGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRY 600 610 620 630 640 650 800 810 820 830 840 850 pF1KE3 KKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEMLSVSSSTHFTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEMLSVSSSTHFTR 660 670 680 690 700 710 860 870 880 890 900 910 pF1KE3 MRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENSSPECTVHLEKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENSSPECTVHLEKT 720 730 740 750 760 770 920 930 940 950 960 970 pF1KE3 GKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKGRPHSQCLNSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKGRPHSQCLNSSP 780 790 800 810 820 830 980 990 1000 1010 1020 1030 pF1KE3 LSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHR 840 850 860 870 880 890 1040 1050 1060 1070 1080 1090 pF1KE3 NCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNSMTLDLNSSSKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNSMTLDLNSSSKC 900 910 920 930 940 950 1100 1110 1120 1130 1140 1150 pF1KE3 DDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKS 960 970 980 990 1000 1010 1160 1170 1180 1190 1200 1210 pF1KE3 EVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVE 1020 1030 1040 1050 1060 1070 1220 1230 1240 1250 1260 1270 pF1KE3 NGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAV 1080 1090 1100 1110 1120 1130 1280 1290 1300 1310 1320 1330 pF1KE3 KQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSV 1140 1150 1160 1170 1180 1190 1340 1350 1360 1370 1380 1390 pF1KE3 AHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGA 1200 1210 1220 1230 1240 1250 1400 1410 1420 1430 1440 1450 pF1KE3 AARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNA 1260 1270 1280 1290 1300 1310 1460 1470 1480 1490 1500 1510 pF1KE3 EKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTT 1320 1330 1340 1350 1360 1370 pF1KE3 W : XP_016 W >>XP_016864974 (OMIM: 600982,613762) PREDICTED: mitogen- (1349 aa) initn: 8974 init1: 8974 opt: 8974 Z-score: 3664.3 bits: 690.6 E(87639): 2.4e-197 Smith-Waterman score: 8974; 100.0% identity (100.0% similar) in 1349 aa overlap (164-1512:1-1349) 140 150 160 170 180 190 pF1KE3 GASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRPEERMIREKLKATC :::::::::::::::::::::::::::::: XP_016 MENKETLKGLHKMDDRPEERMIREKLKATC 10 20 30 200 210 220 230 240 250 pF1KE3 MPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASAASPASKGRRSPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASAASPASKGRRSPSP 40 50 60 70 80 90 260 270 280 290 300 310 pF1KE3 GNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETNRRVNKVMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETNRRVNKVMR 100 110 120 130 140 150 320 330 340 350 360 370 pF1KE3 ARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLFVMLRVFQLEPSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLFVMLRVFQLEPSDP 160 170 180 190 200 210 380 390 400 410 420 430 pF1KE3 MLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSSEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSSEN 220 230 240 250 260 270 440 450 460 470 480 490 pF1KE3 SIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRS 280 290 300 310 320 330 500 510 520 530 540 550 pF1KE3 KWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFNLTHYGTQQIPPAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFNLTHYGTQQIPPAY 340 350 360 370 380 390 560 570 580 590 600 610 pF1KE3 KDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGSSGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGSSGSS 400 410 420 430 440 450 620 630 640 650 660 670 pF1KE3 PSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAER 460 470 480 490 500 510 680 690 700 710 720 730 pF1KE3 IKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGIGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGIGG 520 530 540 550 560 570 740 750 760 770 780 790 pF1KE3 VDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKK 580 590 600 610 620 630 800 810 820 830 840 850 pF1KE3 LLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEMLSVSSSTHFTRMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEMLSVSSSTHFTRMR 640 650 660 670 680 690 860 870 880 890 900 910 pF1KE3 RRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENSSPECTVHLEKTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENSSPECTVHLEKTGK 700 710 720 730 740 750 920 930 940 950 960 970 pF1KE3 GLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKGRPHSQCLNSSPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKGRPHSQCLNSSPLS 760 770 780 790 800 810 980 990 1000 1010 1020 1030 pF1KE3 HHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNC 820 830 840 850 860 870 1040 1050 1060 1070 1080 1090 pF1KE3 PENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNSMTLDLNSSSKCDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNSMTLDLNSSSKCDD 880 890 900 910 920 930 1100 1110 1120 1130 1140 1150 pF1KE3 SFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEV 940 950 960 970 980 990 1160 1170 1180 1190 1200 1210 pF1KE3 AVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENG 1000 1010 1020 1030 1040 1050 1220 1230 1240 1250 1260 1270 pF1KE3 EDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQ 1060 1070 1080 1090 1100 1110 1280 1290 1300 1310 1320 1330 pF1KE3 VTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAH 1120 1130 1140 1150 1160 1170 1340 1350 1360 1370 1380 1390 pF1KE3 LLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAA 1180 1190 1200 1210 1220 1230 1400 1410 1420 1430 1440 1450 pF1KE3 RLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEK 1240 1250 1260 1270 1280 1290 1460 1470 1480 1490 1500 1510 pF1KE3 HSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW 1300 1310 1320 1330 1340 >>NP_001317360 (OMIM: 602539) mitogen-activated protein (622 aa) initn: 634 init1: 219 opt: 716 Z-score: 317.6 bits: 70.2 E(87639): 6.2e-11 Smith-Waterman score: 716; 31.0% identity (60.2% similar) in 507 aa overlap (1016-1505:129-615) 990 1000 1010 1020 1030 1040 pF1KE3 PSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDKLSPV :.::.. . ..... . . . .: NP_001 DLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPP 100 110 120 130 140 150 1050 1060 1070 1080 1090 pF1KE3 FTQSRPLPSSNIHRPKPSRPTPGNTS-KQGDPSKNSMTLDLNSSSKC--DDSFGCS---- .:: : :. . : : : :: . .: .... ..:: .. . : : NP_001 EPRSRHLSVSS-QNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPL 160 170 180 190 200 210 1100 1110 1120 1130 1140 1150 pF1KE3 SNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTV---TF--KSEV :.. :.. : ... .: .: :.. . .. .. . : : :. . .: NP_001 SSAENSLSGSCQSLDSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHV 220 230 240 250 260 270 1160 1170 1180 1190 1200 1210 pF1KE3 AVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENG .: . ... :. . ..: . . . . :. . . : .:. .. NP_001 SVHHKDYSDGRRTFPR-IRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADS 280 290 300 310 320 330 1220 1230 1240 1250 1260 1270 pF1KE3 EDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQ :. . .:. ...: .:.: .: .:. .: :::. : :: :: .: :: NP_001 ENALSVQE---RNVP----TKSP-SAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQ 340 350 360 370 380 1280 1290 1300 1310 1320 1330 pF1KE3 VTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNL--FIEWMAGGSV : . : : . : ::. ::.....:.: :... : .... .: :.:.: :::: NP_001 VQF-DPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSV 390 400 410 420 430 440 1340 1350 1360 1370 1380 1390 pF1KE3 AHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGA :. :::. :::. .::.:.:.:.:::: :.:.:::.::::.: ::.:. ....:::: NP_001 KDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGN-VKLGDFGA 450 460 470 480 490 500 1400 1410 1420 1430 1440 pF1KE3 AARLAS---KGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPP . :: . .::: . .. :: .:.:::. :. :::. ::::.::...:: ::: NP_001 SKRLQTICMSGTG----MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP 510 520 530 540 550 560 1450 1460 1470 1480 1490 1500 pF1KE3 WNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVF : :: .. .: :::::. : :..:::.: :: :: . .. ..:: ..::: : NP_001 W-AEYEA--MAAIFKIATQPTNPQLPSHISEHGRDF-LRRIFVEARQRPSAEELLTHHFA 570 580 590 600 610 1510 pF1KE3 RTTW NP_001 QLMY 620 >>XP_005257433 (OMIM: 602539) PREDICTED: mitogen-activat (653 aa) initn: 634 init1: 219 opt: 716 Z-score: 317.3 bits: 70.2 E(87639): 6.3e-11 Smith-Waterman score: 716; 31.0% identity (60.2% similar) in 507 aa overlap (1016-1505:160-646) 990 1000 1010 1020 1030 1040 pF1KE3 PSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDKLSPV :.::.. . ..... . . . .: XP_005 DLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPP 130 140 150 160 170 180 1050 1060 1070 1080 1090 pF1KE3 FTQSRPLPSSNIHRPKPSRPTPGNTS-KQGDPSKNSMTLDLNSSSKC--DDSFGCS---- .:: : :. . : : : :: . .: .... ..:: .. . : : XP_005 EPRSRHLSVSS-QNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPL 190 200 210 220 230 240 1100 1110 1120 1130 1140 1150 pF1KE3 SNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTV---TF--KSEV :.. :.. : ... .: .: :.. . .. .. . : : :. . .: XP_005 SSAENSLSGSCQSLDSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHV 250 260 270 280 290 300 1160 1170 1180 1190 1200 1210 pF1KE3 AVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENG .: . ... :. . ..: . . . . :. . . : .:. .. XP_005 SVHHKDYSDGRRTFPR-IRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADS 310 320 330 340 350 360 1220 1230 1240 1250 1260 1270 pF1KE3 EDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQ :. . .:. ...: .:.: .: .:. .: :::. : :: :: .: :: XP_005 ENALSVQE---RNVP----TKSP-SAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQ 370 380 390 400 410 1280 1290 1300 1310 1320 1330 pF1KE3 VTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNL--FIEWMAGGSV : . : : . : ::. ::.....:.: :... : .... .: :.:.: :::: XP_005 VQF-DPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSV 420 430 440 450 460 470 1340 1350 1360 1370 1380 1390 pF1KE3 AHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGA :. :::. :::. .::.:.:.:.:::: :.:.:::.::::.: ::.:. ....:::: XP_005 KDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGN-VKLGDFGA 480 490 500 510 520 530 1400 1410 1420 1430 1440 pF1KE3 AARLAS---KGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPP . :: . .::: . .. :: .:.:::. :. :::. ::::.::...:: ::: XP_005 SKRLQTICMSGTG----MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP 540 550 560 570 580 590 1450 1460 1470 1480 1490 1500 pF1KE3 WNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVF : :: .. .: :::::. : :..:::.: :: :: . .. ..:: ..::: : XP_005 W-AEYEA--MAAIFKIATQPTNPQLPSHISEHGRDF-LRRIFVEARQRPSAEELLTHHFA 600 610 620 630 640 1510 pF1KE3 RTTW XP_005 QLMY 650 >>NP_002392 (OMIM: 602539) mitogen-activated protein kin (626 aa) initn: 634 init1: 219 opt: 714 Z-score: 316.7 bits: 70.0 E(87639): 6.9e-11 Smith-Waterman score: 714; 31.1% identity (59.9% similar) in 511 aa overlap (1016-1505:129-619) 990 1000 1010 1020 1030 1040 pF1KE3 PSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDKLSPV :.::.. . ..... . . . .: NP_002 DLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPP 100 110 120 130 140 150 1050 1060 1070 1080 1090 pF1KE3 FTQSRPLPSSNIHRPKPSRPTPGNTS-KQGDPSKNSMTLDLNS--------SSKCD-DSF .:: : :. . : : : :: . .: .... ..:: : .: : . NP_002 EPRSRHLSVSS-QNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPL 160 170 180 190 200 210 1100 1110 1120 1130 1140 pF1KE3 GCSSNSSNAVIPS-DETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTV---TF-- . . :: .. : :... .: .: :.. . .. .. . : : :. NP_002 SSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPR 220 230 240 250 260 270 1150 1160 1170 1180 1190 1200 pF1KE3 KSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQ . .:.: . ... :. . ..: . . . . :. . . : .:. NP_002 RYHVSVHHKDYSDGRRTFPR-IRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLR 280 290 300 310 320 330 1210 1220 1230 1240 1250 1260 pF1KE3 VENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLM ..:. . .:. ...: .:.: .: .:. .: :::. : :: :: . NP_002 SADSENALSVQE---RNVP----TKSP-SAPINWRRGKLLGQGAFGRVYLCYDVDTGREL 340 350 360 370 380 1270 1280 1290 1300 1310 1320 pF1KE3 AVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNL--FIEWMA : ::: . : : . : ::. ::.....:.: :... : .... .: :.:.: NP_002 ASKQVQF-DPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMP 390 400 410 420 430 440 1330 1340 1350 1360 1370 1380 pF1KE3 GGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIA :::: :. :::. :::. .::.:.:.:.:::: :.:.:::.::::.: ::.:. .... NP_002 GGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGN-VKLG 450 460 470 480 490 500 1390 1400 1410 1420 1430 1440 pF1KE3 DFGAAARLAS---KGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMAC ::::. :: . .::: . .. :: .:.:::. :. :::. ::::.::...:: NP_002 DFGASKRLQTICMSGTG----MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLT 510 520 530 540 550 560 1450 1460 1470 1480 1490 1500 pF1KE3 AKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLK :::: :: .. .: :::::. : :..:::.: :: :: . .. ..:: ..::: NP_002 EKPPW-AEYEA--MAAIFKIATQPTNPQLPSHISEHGRDF-LRRIFVEARQRPSAEELLT 570 580 590 600 610 1510 pF1KE3 HPVFRTTW : NP_002 HHFAQLMY 620 >>NP_976226 (OMIM: 602539) mitogen-activated protein kin (657 aa) initn: 634 init1: 219 opt: 714 Z-score: 316.5 bits: 70.1 E(87639): 7e-11 Smith-Waterman score: 714; 31.1% identity (59.9% similar) in 511 aa overlap (1016-1505:160-650) 990 1000 1010 1020 1030 1040 pF1KE3 PSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDKLSPV :.::.. . ..... . . . .: NP_976 DLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPP 130 140 150 160 170 180 1050 1060 1070 1080 1090 pF1KE3 FTQSRPLPSSNIHRPKPSRPTPGNTS-KQGDPSKNSMTLDLNS--------SSKCD-DSF .:: : :. . : : : :: . .: .... ..:: : .: : . NP_976 EPRSRHLSVSS-QNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPL 190 200 210 220 230 240 1100 1110 1120 1130 1140 pF1KE3 GCSSNSSNAVIPS-DETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTV---TF-- . . :: .. : :... .: .: :.. . .. .. . : : :. NP_976 SSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPR 250 260 270 280 290 300 1150 1160 1170 1180 1190 1200 pF1KE3 KSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQ . .:.: . ... :. . ..: . . . . :. . . : .:. NP_976 RYHVSVHHKDYSDGRRTFPR-IRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLR 310 320 330 340 350 360 1210 1220 1230 1240 1250 1260 pF1KE3 VENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLM ..:. . .:. ...: .:.: .: .:. .: :::. : :: :: . NP_976 SADSENALSVQE---RNVP----TKSP-SAPINWRRGKLLGQGAFGRVYLCYDVDTGREL 370 380 390 400 410 1270 1280 1290 1300 1310 1320 pF1KE3 AVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNL--FIEWMA : ::: . : : . : ::. ::.....:.: :... : .... .: :.:.: NP_976 ASKQVQF-DPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMP 420 430 440 450 460 470 1330 1340 1350 1360 1370 1380 pF1KE3 GGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIA :::: :. :::. :::. .::.:.:.:.:::: :.:.:::.::::.: ::.:. .... NP_976 GGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGN-VKLG 480 490 500 510 520 530 1390 1400 1410 1420 1430 1440 pF1KE3 DFGAAARLAS---KGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMAC ::::. :: . .::: . .. :: .:.:::. :. :::. ::::.::...:: NP_976 DFGASKRLQTICMSGTG----MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLT 540 550 560 570 580 590 1450 1460 1470 1480 1490 1500 pF1KE3 AKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLK :::: :: .. .: :::::. : :..:::.: :: :: . .. ..:: ..::: NP_976 EKPPW-AEYEA--MAAIFKIATQPTNPQLPSHISEHGRDF-LRRIFVEARQRPSAEELLT 600 610 620 630 640 1510 pF1KE3 HPVFRTTW : NP_976 HHFAQLMY 650 >>NP_006600 (OMIM: 609487) mitogen-activated protein kin (619 aa) initn: 591 init1: 240 opt: 682 Z-score: 303.8 bits: 67.6 E(87639): 3.6e-10 Smith-Waterman score: 682; 41.8% identity (69.3% similar) in 280 aa overlap (1233-1505:347-613) 1210 1220 1230 1240 1250 1260 pF1KE3 PIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQD ...: : :.: :. .: :::. : : NP_006 FTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSP-RAPTNWRLGKLLGQGAFGRVYLCYD 320 330 340 350 360 370 1270 1280 1290 1300 1310 pF1KE3 VGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATC----EKSN : :: .::::: . : : . :.::. ::.....: : :... : : .... NP_006 VDTGRELAVKQVQF-DPDSPETSKEVNALECEIQLLKNLLHERIVQYYG--CLRDPQEKT 380 390 400 410 420 430 1320 1330 1340 1350 1360 1370 pF1KE3 YNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLID ..:.:.: :::. :. :::. :.:. .::.:.:.:. ::: :.:.:::.::::.: : NP_006 LSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRD 440 450 460 470 480 490 1380 1390 1400 1410 1420 1430 pF1KE3 STGQRLRIADFGAAARLAS---KGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSV :::. ....::::. :: . .::: . .. :: .:.:::. :. :::. :.::: NP_006 STGN-VKLGDFGASKRLQTICLSGTG----MKSVTGTPYWMSPEVISGEGYGRKADIWSV 500 510 520 530 540 1440 1450 1460 1470 1480 1490 pF1KE3 GCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQD .:...:: :::: :: .. .: :::::. : :..: :.: :: :. . .. . NP_006 ACTVVEMLTEKPPW-AEFEA--MAAIFKIATQPTNPKLPPHVSDYTRDF-LKRIFVEAKL 550 560 570 580 590 600 1500 1510 pF1KE3 RPPSRELLKHPVFRTTW :: . :::.: NP_006 RPSADELLRHMFVHYH 610 >>XP_011543813 (OMIM: 300820) PREDICTED: mitogen-activat (748 aa) initn: 449 init1: 239 opt: 583 Z-score: 262.8 bits: 60.3 E(87639): 6.9e-08 Smith-Waterman score: 583; 36.1% identity (66.7% similar) in 288 aa overlap (1227-1509:69-344) 1200 1210 1220 1230 1240 1250 pF1KE3 ASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQI--GLGAF : :.: . : . .:... : :.. XP_011 QIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEYEYDHDANGERVVLGKGTY 40 50 60 70 80 90 1260 1270 1280 1290 1300 1310 pF1KE3 SSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATC . : ..:... . .:.:.. :.. : :.::: . ..:.: ::...::.. XP_011 GIVYAGRDLSNQVRIAIKEIPE-RDSRYSQP-----LHEEIALHKYLKHRNIVQYLGSVS 100 110 120 130 140 150 1320 1330 1340 1350 1360 1370 pF1KE3 EKSNYNLFIEWMAGGSVAHLL-SKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGA :.. ..:.: . :::.. :: ::.: .:: .. ::.:.:.::.:::::::.:::.:: XP_011 ENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGD 160 170 180 190 200 210 1380 1390 1400 1410 1420 1430 pF1KE3 NLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL-RGQQ-YGRSCD :.:... . ..:.:::.. ::: :.. . ::. .::::.. .: . :: : XP_011 NVLVNTYSGVVKISDFGTSKRLA----GVNPCTETFTGTLQYMAPEIIDQGPRGYGAPAD 220 230 240 250 260 1440 1450 1460 1470 1480 1490 pF1KE3 VWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLEL .::.::.::::: .:::.. . .. : .::.. : :: :: : : :.: XP_011 IWSLGCTIIEMATSKPPFH--ELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEP 270 280 290 300 310 320 1500 1510 pF1KE3 QPQDRPPSRELLKHPVFRTTW .:. : . :::.. .: XP_011 DPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSV 330 340 350 360 370 380 >>XP_011543812 (OMIM: 300820) PREDICTED: mitogen-activat (871 aa) initn: 449 init1: 239 opt: 583 Z-score: 262.1 bits: 60.4 E(87639): 7.6e-08 Smith-Waterman score: 583; 36.1% identity (66.7% similar) in 288 aa overlap (1227-1509:192-467) 1200 1210 1220 1230 1240 1250 pF1KE3 ASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQI--GLGAF : :.: . : . .:... : :.. XP_011 QIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEYEYDHDANGERVVLGKGTY 170 180 190 200 210 220 1260 1270 1280 1290 1300 1310 pF1KE3 SSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATC . : ..:... . .:.:.. :.. : :.::: . ..:.: ::...::.. XP_011 GIVYAGRDLSNQVRIAIKEIPE-RDSRYSQP-----LHEEIALHKYLKHRNIVQYLGSVS 230 240 250 260 270 1320 1330 1340 1350 1360 1370 pF1KE3 EKSNYNLFIEWMAGGSVAHLL-SKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGA :.. ..:.: . :::.. :: ::.: .:: .. ::.:.:.::.:::::::.:::.:: XP_011 ENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGD 280 290 300 310 320 330 1380 1390 1400 1410 1420 1430 pF1KE3 NLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL-RGQQ-YGRSCD :.:... . ..:.:::.. ::: :.. . ::. .::::.. .: . :: : XP_011 NVLVNTYSGVVKISDFGTSKRLA----GVNPCTETFTGTLQYMAPEIIDQGPRGYGAPAD 340 350 360 370 380 390 1440 1450 1460 1470 1480 1490 pF1KE3 VWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLEL .::.::.::::: .:::.. . .. : .::.. : :: :: : : :.: XP_011 IWSLGCTIIEMATSKPPFH--ELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEP 400 410 420 430 440 1500 1510 pF1KE3 QPQDRPPSRELLKHPVFRTTW .:. : . :::.. .: XP_011 DPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSV 450 460 470 480 490 500 1512 residues in 1 query sequences 62246620 residues in 87639 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Jul 13 16:35:30 2017 done: Thu Jul 13 16:35:32 2017 Total Scan time: 13.370 Total Display time: 0.240 Function used was FASTA [36.3.4 Apr, 2011]