FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5721, 690 aa 1>>>pF1KE5721 690 - 690 aa - 690 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.4273+/-0.00052; mu= 0.7167+/- 0.033 mean_var=256.4049+/-51.886, 0's: 0 Z-trim(116.0): 93 B-trim: 1135 in 1/53 Lambda= 0.080096 statistics sampled from 26838 (26931) to 26838 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.638), E-opt: 0.2 (0.316), width: 16 Scan time: 10.040 The best scores are: opt bits E(85289) XP_011511925 (OMIM: 123825,268000,613756) PREDICTE ( 690) 4507 535.0 3.7e-151 NP_000078 (OMIM: 123825,268000,613756) cGMP-gated ( 690) 4507 535.0 3.7e-151 XP_016863201 (OMIM: 123825,268000,613756) PREDICTE ( 690) 4507 535.0 3.7e-151 NP_001136036 (OMIM: 123825,268000,613756) cGMP-gat ( 759) 4507 535.0 4e-151 XP_005248106 (OMIM: 123825,268000,613756) PREDICTE ( 765) 4507 535.0 4e-151 NP_001289 (OMIM: 216900,600053) cyclic nucleotide- ( 694) 2759 333.0 2.4e-90 XP_011508856 (OMIM: 216900,600053) PREDICTED: cycl ( 749) 2759 333.0 2.5e-90 XP_006712306 (OMIM: 216900,600053) PREDICTED: cycl ( 731) 2750 331.9 5.1e-90 NP_001073347 (OMIM: 216900,600053) cyclic nucleoti ( 676) 2745 331.3 7.2e-90 NP_005131 (OMIM: 300338) cyclic nucleotide-gated o ( 664) 2609 315.6 3.8e-85 NP_001032406 (OMIM: 609472) cyclic nucleotide-gate ( 575) 1976 242.4 3.6e-63 XP_016872706 (OMIM: 609472) PREDICTED: cyclic nucl ( 577) 1962 240.8 1.1e-62 XP_016872707 (OMIM: 609472) PREDICTED: cyclic nucl ( 537) 1880 231.3 7.4e-60 XP_016872708 (OMIM: 609472) PREDICTED: cyclic nucl ( 537) 1880 231.3 7.4e-60 XP_011521172 (OMIM: 600724,613767) PREDICTED: cycl ( 868) 922 120.8 2.2e-26 NP_001273059 (OMIM: 600724,613767) cyclic nucleoti (1245) 922 120.9 2.9e-26 NP_001288 (OMIM: 600724,613767) cyclic nucleotide- (1251) 922 120.9 3e-26 NP_061971 (OMIM: 248200,262300,605080) cyclic nucl ( 809) 913 119.7 4.4e-26 XP_011515440 (OMIM: 248200,262300,605080) PREDICTE ( 671) 909 119.2 5.2e-26 NP_066550 (OMIM: 602780,615871) potassium/sodium h ( 890) 555 78.4 1.3e-13 NP_005468 (OMIM: 163800,605206,613123) potassium/s (1203) 546 77.4 3.4e-13 XP_011519450 (OMIM: 163800,605206,613123) PREDICTE ( 797) 520 74.3 2e-12 XP_011508118 (OMIM: 609973) PREDICTED: potassium/s ( 727) 519 74.1 2e-12 NP_065948 (OMIM: 609973) potassium/sodium hyperpol ( 774) 519 74.2 2.1e-12 NP_001185 (OMIM: 602781) potassium/sodium hyperpol ( 889) 511 73.3 4.5e-12 XP_011508120 (OMIM: 609973) PREDICTED: potassium/s ( 535) 493 71.0 1.3e-11 XP_016857407 (OMIM: 609973) PREDICTED: potassium/s ( 535) 493 71.0 1.3e-11 XP_011523615 (OMIM: 608168) PREDICTED: potassium v ( 711) 438 64.8 1.3e-09 XP_011523614 (OMIM: 608168) PREDICTED: potassium v ( 726) 438 64.8 1.3e-09 XP_011523613 (OMIM: 608168) PREDICTED: potassium v ( 726) 438 64.8 1.3e-09 NP_001265849 (OMIM: 608168) potassium voltage-gate ( 835) 438 64.8 1.5e-09 XP_016860709 (OMIM: 608169) PREDICTED: potassium v (1189) 441 65.3 1.5e-09 NP_150375 (OMIM: 608169) potassium voltage-gated c (1196) 441 65.3 1.5e-09 XP_016880669 (OMIM: 608168) PREDICTED: potassium v ( 871) 438 64.8 1.5e-09 XP_011510411 (OMIM: 608169) PREDICTED: potassium v (1204) 441 65.3 1.6e-09 XP_011523611 (OMIM: 608168) PREDICTED: potassium v ( 915) 438 64.9 1.6e-09 XP_011523610 (OMIM: 608168) PREDICTED: potassium v ( 918) 438 64.9 1.6e-09 XP_016880667 (OMIM: 608168) PREDICTED: potassium v ( 947) 438 64.9 1.6e-09 NP_001265848 (OMIM: 608168) potassium voltage-gate ( 958) 438 64.9 1.7e-09 XP_016880666 (OMIM: 608168) PREDICTED: potassium v ( 958) 438 64.9 1.7e-09 XP_016880665 (OMIM: 608168) PREDICTED: potassium v ( 983) 438 64.9 1.7e-09 XP_016880664 (OMIM: 608168) PREDICTED: potassium v ( 994) 438 64.9 1.7e-09 NP_110406 (OMIM: 608168) potassium voltage-gated c ( 994) 438 64.9 1.7e-09 XP_011508119 (OMIM: 609973) PREDICTED: potassium/s ( 720) 417 62.4 7.2e-09 NP_742054 (OMIM: 152427,609620,613688) potassium v ( 819) 417 62.4 7.9e-09 XP_011514488 (OMIM: 152427,609620,613688) PREDICTE ( 910) 417 62.4 8.6e-09 XP_011514487 (OMIM: 152427,609620,613688) PREDICTE (1059) 417 62.5 9.6e-09 XP_016867685 (OMIM: 152427,609620,613688) PREDICTE (1100) 417 62.5 9.9e-09 XP_016867684 (OMIM: 152427,609620,613688) PREDICTE (1109) 417 62.5 1e-08 NP_000229 (OMIM: 152427,609620,613688) potassium v (1159) 417 62.5 1e-08 >>XP_011511925 (OMIM: 123825,268000,613756) PREDICTED: c (690 aa) initn: 4507 init1: 4507 opt: 4507 Z-score: 2834.7 bits: 535.0 E(85289): 3.7e-151 Smith-Waterman score: 4507; 100.0% identity (100.0% similar) in 690 aa overlap (1-690:1-690) 10 20 30 40 50 60 pF1KE5 MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 HARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 ENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 TMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 KSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 SNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 TTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 MHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 ADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE5 GSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE5 QILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLT 610 620 630 640 650 660 670 680 690 pF1KE5 KVEKFLKPLIDTEFSSIEGPGAESGPIDST :::::::::::::::::::::::::::::: XP_011 KVEKFLKPLIDTEFSSIEGPGAESGPIDST 670 680 690 >>NP_000078 (OMIM: 123825,268000,613756) cGMP-gated cati (690 aa) initn: 4507 init1: 4507 opt: 4507 Z-score: 2834.7 bits: 535.0 E(85289): 3.7e-151 Smith-Waterman score: 4507; 100.0% identity (100.0% similar) in 690 aa overlap (1-690:1-690) 10 20 30 40 50 60 pF1KE5 MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 HARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 ENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 TMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 KSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 SNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 TTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 MHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 ADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE5 GSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE5 QILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLT 610 620 630 640 650 660 670 680 690 pF1KE5 KVEKFLKPLIDTEFSSIEGPGAESGPIDST :::::::::::::::::::::::::::::: NP_000 KVEKFLKPLIDTEFSSIEGPGAESGPIDST 670 680 690 >>XP_016863201 (OMIM: 123825,268000,613756) PREDICTED: c (690 aa) initn: 4507 init1: 4507 opt: 4507 Z-score: 2834.7 bits: 535.0 E(85289): 3.7e-151 Smith-Waterman score: 4507; 100.0% identity (100.0% similar) in 690 aa overlap (1-690:1-690) 10 20 30 40 50 60 pF1KE5 MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 HARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 ENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 TMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 KSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 SNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 TTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 MHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 ADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE5 GSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE5 QILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLT 610 620 630 640 650 660 670 680 690 pF1KE5 KVEKFLKPLIDTEFSSIEGPGAESGPIDST :::::::::::::::::::::::::::::: XP_016 KVEKFLKPLIDTEFSSIEGPGAESGPIDST 670 680 690 >>NP_001136036 (OMIM: 123825,268000,613756) cGMP-gated c (759 aa) initn: 4507 init1: 4507 opt: 4507 Z-score: 2834.1 bits: 535.0 E(85289): 4e-151 Smith-Waterman score: 4507; 100.0% identity (100.0% similar) in 690 aa overlap (1-690:70-759) 10 20 30 pF1KE5 MKLSMKNNIINTQQSFVTMPNVIVPDIEKE :::::::::::::::::::::::::::::: NP_001 GFHHVGQAGLELLISSDLPTSASQSAGITDMKLSMKNNIINTQQSFVTMPNVIVPDIEKE 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE5 IRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALF 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE5 NVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEE 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE5 EKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIV 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE5 YLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEI 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE5 RLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGND 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE5 TWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFA 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE5 TIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDE 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE5 KEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKG 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE5 DIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGY 580 590 600 610 620 630 580 590 600 610 620 630 pF1KE5 SDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRM 640 650 660 670 680 690 640 650 660 670 680 690 pF1KE5 EGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST 700 710 720 730 740 750 >>XP_005248106 (OMIM: 123825,268000,613756) PREDICTED: c (765 aa) initn: 4507 init1: 4507 opt: 4507 Z-score: 2834.1 bits: 535.0 E(85289): 4e-151 Smith-Waterman score: 4507; 100.0% identity (100.0% similar) in 690 aa overlap (1-690:76-765) 10 20 30 pF1KE5 MKLSMKNNIINTQQSFVTMPNVIVPDIEKE :::::::::::::::::::::::::::::: XP_005 LARLLEPRTRETQTRLIEQQRLSERGARQDMKLSMKNNIINTQQSFVTMPNVIVPDIEKE 50 60 70 80 90 100 40 50 60 70 80 90 pF1KE5 IRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALF 110 120 130 140 150 160 100 110 120 130 140 150 pF1KE5 NVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEE 170 180 190 200 210 220 160 170 180 190 200 210 pF1KE5 EKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIV 230 240 250 260 270 280 220 230 240 250 260 270 pF1KE5 YLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEI 290 300 310 320 330 340 280 290 300 310 320 330 pF1KE5 RLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGND 350 360 370 380 390 400 340 350 360 370 380 390 pF1KE5 TWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFA 410 420 430 440 450 460 400 410 420 430 440 450 pF1KE5 TIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDE 470 480 490 500 510 520 460 470 480 490 500 510 pF1KE5 KEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKG 530 540 550 560 570 580 520 530 540 550 560 570 pF1KE5 DIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGY 590 600 610 620 630 640 580 590 600 610 620 630 pF1KE5 SDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRM 650 660 670 680 690 700 640 650 660 670 680 690 pF1KE5 EGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST 710 720 730 740 750 760 >>NP_001289 (OMIM: 216900,600053) cyclic nucleotide-gate (694 aa) initn: 2803 init1: 2748 opt: 2759 Z-score: 1743.0 bits: 333.0 E(85289): 2.4e-90 Smith-Waterman score: 2806; 62.3% identity (84.5% similar) in 684 aa overlap (10-681:4-684) 10 20 30 40 50 pF1KE5 MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSE-----ES :::: : . .. : .... : ::: . : .....:. . :. NP_001 MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMET 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 ENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSN-KDQEPEE-KKKKKKEKK .. ..:::. ... . .: .: : .:..... :. :.. . . :: . NP_001 RGLADSGQGSFTGQGIAR---LSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVS 60 70 80 90 100 110 120 130 140 150 160 pF1KE5 SKSDDKNENKNDPEKKKKKKD-----KEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNW :. .. . : .. : . .. : . . ......:. .::...:.:::.: :: : NP_001 SQESNAQANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRW 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE5 LFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGL : :.:::.::: ..: :::::::::.:: ::.::: .:..:..:..::.:::.::::: NP_001 LTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE5 LVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRT .:.. .: ..::.. :::::::::.:::: :.:.: ::::.:.::::.:::.::::.:: NP_001 MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRT 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE5 ETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARK ::::::::.:::.:::.::.::::::::....::: ::::.:.::::.:. :: :::.:: NP_001 ETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRK 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE5 YVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARA :.::::::::::::::::::::.: ::.:::::::.:::::::::::.:::::::::.:: NP_001 YIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRA 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE5 EFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAIN ::::.::.:::::.::.:.::.: :::.::::::.:::::::::::: :::::.:::::: NP_001 EFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAIN 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE5 VHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVA :::::::::::: ::::::::::::::.: :.:::::::::::::.:::::.:::::::: NP_001 VHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVA 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE5 DDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEY ::::::::::::::::::::::::::::.::::::::.:::::::::::::::::::::: NP_001 DDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEY 540 550 560 570 580 590 590 600 610 620 630 640 pF1KE5 PDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEY :.:: :::::.::::::.:.: ..: ::.::::::::: .. .:.: :::::::.:::: NP_001 PEAKKALEEKGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEY 600 610 620 630 640 650 650 660 670 680 690 pF1KE5 ESMQQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST .. :.:.::::...:. .: : ... : :: NP_001 NATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ 660 670 680 690 >>XP_011508856 (OMIM: 216900,600053) PREDICTED: cyclic n (749 aa) initn: 2803 init1: 2748 opt: 2759 Z-score: 1742.6 bits: 333.0 E(85289): 2.5e-90 Smith-Waterman score: 2768; 66.9% identity (86.9% similar) in 617 aa overlap (75-681:123-739) 50 60 70 80 90 100 pF1KE5 DDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPE- ::. : . : . . . . ..:: :. XP_011 RPLIGWTQWCAEDGGDESEMALAGSPGCSSGPQGRLSRLIFLLRRWAARHVHHQDQGPDS 100 110 120 130 140 150 110 120 130 140 150 pF1KE5 --EKKKKKKEKKSKSDDKNENKN----DPEKKKKKKDKEKKKKEEKSKDKKEEEK---KE .. . . :. .:...: . : .: . .. : . . :.. .::.: :. XP_011 FPDRFRGAELKEVSSQESNAQANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKD 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE5 VVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLID ..:.:::.: :: :: :.:::.::: ..: :::::::::.:: ::.::: .:..:..: XP_011 AIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLD 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE5 MFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNR ..::.:::.:::::.:.. .: ..::.. :::::::::.:::: :.:.: ::::.:.:: XP_011 VLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNR 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE5 LLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVY ::.:::.::::.::::::::::.:::.:::.::.::::::::....::: ::::.:.::: XP_011 LLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVY 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE5 PDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVG :.:. :: :::.:::.::::::::::::::::::::.: ::.:::::::.:::::::::: XP_011 PNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVG 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE5 NIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVL :.:::::::::.::::::.::.:::::.::.:.::.: :::.::::::.::::::::::: XP_011 NVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVL 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE5 KYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGR : :::::.:::::::::::::::::: ::::::::::::::.: :.:::::::::::::. XP_011 KSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGK 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE5 EMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLF :::::.::::::::::::::::::::::::::::::::::::.::::::::.:::::::: XP_011 EMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLF 580 590 600 610 620 630 580 590 600 610 620 630 pF1KE5 CLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSV :::::::::::::::.:: :::::.::::::.:.: ..: ::.::::::::: .. .:. XP_011 CLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSL 640 650 660 670 680 690 640 650 660 670 680 690 pF1KE5 DLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST : :::::::.::::.. :.:.::::...:. .: : ... : :: XP_011 DTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ 700 710 720 730 740 >>XP_006712306 (OMIM: 216900,600053) PREDICTED: cyclic n (731 aa) initn: 2800 init1: 2745 opt: 2750 Z-score: 1737.1 bits: 331.9 E(85289): 5.1e-90 Smith-Waterman score: 2761; 67.4% identity (86.7% similar) in 610 aa overlap (75-681:123-721) 50 60 70 80 90 100 pF1KE5 DDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPE- ::. : . : . . . . ..:: :. XP_006 RPLIGWTQWCAEDGGDESEMALAGSPGCSSGPQGRLSRLIFLLRRWAARHVHHQDQGPDS 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE5 --EKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPS .. . . :. .:...: . : .. . ..:: : ::...:.::: XP_006 FPDRFRGAELKEVSSQESNAQANVGSQEPADRGRRKKTK-----------KKDAIVVDPS 160 170 180 190 200 170 180 190 200 210 220 pF1KE5 GNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRT .: :: :: :.:::.::: ..: :::::::::.:: ::.::: .:..:..:..::.:: XP_006 SNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRART 210 220 230 240 250 260 230 240 250 260 270 280 pF1KE5 GYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRM :.:::::.:.. .: ..::.. :::::::::.:::: :.:.: ::::.:.::::.:::. XP_006 GFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRL 270 280 290 300 310 320 290 300 310 320 330 340 pF1KE5 FEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPE ::::.::::::::::.:::.:::.::.::::::::....::: ::::.:.::::.:. :: XP_006 FEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPE 330 340 350 360 370 380 350 360 370 380 390 400 pF1KE5 FGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMIS :::.:::.::::::::::::::::::::.: ::.:::::::.:::::::::::.::::: XP_006 HGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMIS 390 400 410 420 430 440 410 420 430 440 450 460 pF1KE5 NMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKL ::::.::::::.::.:::::.::.:.::.: :::.::::::.:::::::::::: ::::: XP_006 NMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKL 450 460 470 480 490 500 470 480 490 500 510 520 pF1KE5 RAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKE .:::::::::::::::::: ::::::::::::::.: :.:::::::::::::.:::::.: XP_006 KAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINE 510 520 530 540 550 560 530 540 550 560 570 580 pF1KE5 GKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDL :::::::::::::::::::::::::::::::::::.::::::::.::::::::::::::: XP_006 GKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDL 570 580 590 600 610 620 590 600 610 620 630 640 pF1KE5 MEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRF ::::::::.:: :::::.::::::.:.: ..: ::.::::::::: .. .:.: ::::: XP_006 MEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRF 630 640 650 660 670 680 650 660 670 680 690 pF1KE5 ARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST ::.::::.. :.:.::::...:. .: : ... : :: XP_006 ARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ 690 700 710 720 730 >>NP_001073347 (OMIM: 216900,600053) cyclic nucleotide-g (676 aa) initn: 2800 init1: 2745 opt: 2745 Z-score: 1734.4 bits: 331.3 E(85289): 7.2e-90 Smith-Waterman score: 2798; 62.8% identity (83.5% similar) in 680 aa overlap (10-681:4-666) 10 20 30 40 50 pF1KE5 MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSE-----ES :::: : . .. : .... : ::: . : .....:. . :. NP_001 MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMET 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 ENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPE---EKKKKKKEK .. ..:::. ... . .: .: : .:.. .:: :. .. . . : NP_001 RGLADSGQGSFTGQGIAR---LSRLIFLLRRWAARHVHH---QDQGPDSFPDRFRGAELK 60 70 80 90 100 120 130 140 150 160 170 pF1KE5 KSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCI . .:...: . : .. . ..:: : ::...:.:::.: :: :: : NP_001 EVSSQESNAQANVGSQEPADRGRRKKTK-----------KKDAIVVDPSSNLYYRWLTAI 110 120 130 140 150 180 190 200 210 220 230 pF1KE5 TLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKE .:::.::: ..: :::::::::.:: ::.::: .:..:..:..::.:::.:::::.:.. NP_001 ALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSD 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE5 ELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRT .: ..::.. :::::::::.:::: :.:.: ::::.:.::::.:::.::::.:::::: NP_001 TNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRT 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE5 NYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYS ::::.:::.:::.::.::::::::....::: ::::.:.::::.:. :: :::.:::.:: NP_001 NYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYS 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE5 LYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQA ::::::::::::::::::.: ::.:::::::.:::::::::::.:::::::::.:::::: NP_001 LYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQA 340 350 360 370 380 390 420 430 440 450 460 470 pF1KE5 RIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLD .::.:::::.::.:.::.: :::.::::::.:::::::::::: :::::.:::::::::: NP_001 KIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLD 400 410 420 430 440 450 480 490 500 510 520 530 pF1KE5 TLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGV :::::::: ::::::::::::::.: :.:::::::::::::.:::::.:::::::::::: NP_001 TLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGV 460 470 480 490 500 510 540 550 560 570 580 590 pF1KE5 TQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAK ::::::::::::::::::::::::.::::::::.:::::::::::::::::::::::.:: NP_001 TQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAK 520 530 540 550 560 570 600 610 620 630 640 650 pF1KE5 TMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQ :::::.::::::.:.: ..: ::.::::::::: .. .:.: :::::::.::::.. : NP_001 KALEEKGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQ 580 590 600 610 620 630 660 670 680 690 pF1KE5 QKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST .:.::::...:. .: : ... : :: NP_001 MKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ 640 650 660 670 >>NP_005131 (OMIM: 300338) cyclic nucleotide-gated olfac (664 aa) initn: 2618 init1: 2461 opt: 2609 Z-score: 1649.6 bits: 315.6 E(85289): 3.8e-85 Smith-Waterman score: 2609; 67.2% identity (85.9% similar) in 574 aa overlap (103-676:78-650) 80 90 100 110 120 130 pF1KE5 KGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKK : .:. .:.. . :. : :: . NP_005 SELQRLADVDAPQQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVT 50 60 70 80 90 100 140 150 160 170 180 190 pF1KE5 KDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDEL .. : .. ..:: ..: :. :.::.:. :: ::: :..::.::: ...:::::..: NP_005 TQEGDGKGDKDGEDKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDL 110 120 130 140 150 160 200 210 220 230 240 250 pF1KE5 QSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLS :. : ::.::::::.::. :.:.: :::.::::::::. :: ..: .::::::: : NP_005 QKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVAS 170 180 190 200 210 220 260 270 280 290 300 310 pF1KE5 LIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIH .:::::.:: . . ::.:.::::.:.::::::.::::::::::::::::::.::..::: NP_005 IIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIH 230 240 250 260 270 280 320 330 340 350 360 370 pF1KE5 WNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRD ::::..:.:::.:::: ::::::.:.:::.: :::.:.: ::::::::::::::::::.: NP_005 WNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKD 290 300 310 320 330 340 380 390 400 410 420 430 pF1KE5 SEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEK ::.::. :::::::::::::::.:::::::::.::::::.:::.:.::.::.::: :: NP_005 EEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEA 350 360 370 380 390 400 440 450 460 470 480 490 pF1KE5 RVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELV .::.::::::::::::::.:.:: :: ::::::::::::.:::::::: ::::::::::: NP_005 KVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELV 410 420 430 440 450 460 500 510 520 530 540 550 pF1KE5 LKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNI :::.:::.:::::::.:::::.::::::::::::::::::::...:: :: ::::::::: NP_005 LKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNI 470 480 490 500 510 520 560 570 580 590 600 610 pF1KE5 KGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLN :::: ::::::::.:.::::::::::::::::.::::::: .:::.:..::::.:::: : NP_005 KGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDEN 530 540 550 560 570 580 620 630 640 650 660 670 pF1KE5 IANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDT : : :..::. ..: ... : :::.:.:::: . :::::::.: .: .: . NP_005 -EVATSMEVDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNED 590 600 610 620 630 640 680 690 pF1KE5 EFSSIEGPGAESGPIDST .. : NP_005 DYLSDGMNSPELAAADEP 650 660 690 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 06:04:26 2016 done: Tue Nov 8 06:04:28 2016 Total Scan time: 10.040 Total Display time: 0.170 Function used was FASTA [36.3.4 Apr, 2011]