FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1643, 158 aa 1>>>pF1KE1643 158 - 158 aa - 158 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7545+/-0.000316; mu= 14.8458+/- 0.020 mean_var=57.1779+/-11.348, 0's: 0 Z-trim(115.6): 29 B-trim: 19 in 1/55 Lambda= 0.169613 statistics sampled from 26086 (26116) to 26086 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.702), E-opt: 0.2 (0.306), width: 16 Scan time: 5.330 The best scores are: opt bits E(85289) NP_055255 (OMIM: 605509) interleukin-36 alpha [Hom ( 158) 1059 266.8 1.1e-71 XP_011509267 (OMIM: 605509) PREDICTED: interleukin ( 158) 1059 266.8 1.1e-71 XP_005263696 (OMIM: 605509) PREDICTED: interleukin ( 158) 1059 266.8 1.1e-71 XP_016859295 (OMIM: 605509) PREDICTED: interleukin ( 158) 1059 266.8 1.1e-71 NP_062564 (OMIM: 605542) interleukin-36 gamma isof ( 169) 616 158.4 4.8e-39 XP_011509264 (OMIM: 605508) PREDICTED: interleukin ( 157) 502 130.5 1.1e-30 NP_775270 (OMIM: 605508) interleukin-36 beta isofo ( 157) 502 130.5 1.1e-30 NP_001265497 (OMIM: 605542) interleukin-36 gamma i ( 134) 481 125.3 3.5e-29 NP_775297 (OMIM: 605510) interleukin-37 isoform 5 ( 192) 306 82.6 3.6e-16 NP_775294 (OMIM: 605510) interleukin-37 isoform 2 ( 197) 306 82.6 3.7e-16 XP_011509265 (OMIM: 605510) PREDICTED: interleukin ( 218) 306 82.6 4e-16 NP_055254 (OMIM: 605510) interleukin-37 isoform 1 ( 218) 306 82.6 4e-16 NP_055253 (OMIM: 605508) interleukin-36 beta isofo ( 164) 266 72.7 2.8e-13 NP_775262 (OMIM: 605507,614204) interleukin-36 rec ( 155) 245 67.6 9.5e-12 NP_036407 (OMIM: 605507,614204) interleukin-36 rec ( 155) 245 67.6 9.5e-12 XP_011509423 (OMIM: 137215,147679,612628,612852) P ( 143) 235 65.1 4.9e-11 XP_005263718 (OMIM: 137215,147679,612628,612852) P ( 143) 235 65.1 4.9e-11 NP_776215 (OMIM: 137215,147679,612628,612852) inte ( 143) 235 65.1 4.9e-11 NP_001305843 (OMIM: 137215,147679,612628,612852) i ( 143) 235 65.1 4.9e-11 NP_000568 (OMIM: 137215,147679,612628,612852) inte ( 159) 235 65.1 5.3e-11 NP_776214 (OMIM: 137215,147679,612628,612852) inte ( 177) 235 65.2 5.8e-11 NP_776213 (OMIM: 137215,147679,612628,612852) inte ( 180) 235 65.2 5.9e-11 NP_775184 (OMIM: 615296) interleukin-1 family memb ( 152) 231 64.1 1e-10 NP_115945 (OMIM: 615296) interleukin-1 family memb ( 152) 231 64.1 1e-10 NP_775295 (OMIM: 605510) interleukin-37 isoform 3 ( 157) 220 61.5 6.7e-10 NP_775296 (OMIM: 605510) interleukin-37 isoform 4 ( 178) 220 61.5 7.4e-10 XP_011509266 (OMIM: 605510) PREDICTED: interleukin ( 178) 220 61.5 7.4e-10 XP_016859477 (OMIM: 137215,147720) PREDICTED: inte ( 238) 191 54.5 1.3e-07 NP_000567 (OMIM: 137215,147720) interleukin-1 beta ( 269) 191 54.5 1.4e-07 >>NP_055255 (OMIM: 605509) interleukin-36 alpha [Homo sa (158 aa) initn: 1059 init1: 1059 opt: 1059 Z-score: 1408.3 bits: 266.8 E(85289): 1.1e-71 Smith-Waterman score: 1059; 99.4% identity (100.0% similar) in 158 aa overlap (1-158:1-158) 10 20 30 40 50 60 pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES 70 80 90 100 110 120 130 140 150 pF1KE1 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF :::::::::::::::::::::::::::::::::::::: NP_055 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF 130 140 150 >>XP_011509267 (OMIM: 605509) PREDICTED: interleukin-36 (158 aa) initn: 1059 init1: 1059 opt: 1059 Z-score: 1408.3 bits: 266.8 E(85289): 1.1e-71 Smith-Waterman score: 1059; 99.4% identity (100.0% similar) in 158 aa overlap (1-158:1-158) 10 20 30 40 50 60 pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES 70 80 90 100 110 120 130 140 150 pF1KE1 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF :::::::::::::::::::::::::::::::::::::: XP_011 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF 130 140 150 >>XP_005263696 (OMIM: 605509) PREDICTED: interleukin-36 (158 aa) initn: 1059 init1: 1059 opt: 1059 Z-score: 1408.3 bits: 266.8 E(85289): 1.1e-71 Smith-Waterman score: 1059; 99.4% identity (100.0% similar) in 158 aa overlap (1-158:1-158) 10 20 30 40 50 60 pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES 70 80 90 100 110 120 130 140 150 pF1KE1 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF :::::::::::::::::::::::::::::::::::::: XP_005 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF 130 140 150 >>XP_016859295 (OMIM: 605509) PREDICTED: interleukin-36 (158 aa) initn: 1059 init1: 1059 opt: 1059 Z-score: 1408.3 bits: 266.8 E(85289): 1.1e-71 Smith-Waterman score: 1059; 99.4% identity (100.0% similar) in 158 aa overlap (1-158:1-158) 10 20 30 40 50 60 pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES 70 80 90 100 110 120 130 140 150 pF1KE1 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF :::::::::::::::::::::::::::::::::::::: XP_016 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF 130 140 150 >>NP_062564 (OMIM: 605542) interleukin-36 gamma isoform (169 aa) initn: 617 init1: 561 opt: 616 Z-score: 822.0 bits: 158.4 E(85289): 4.8e-39 Smith-Waterman score: 616; 59.9% identity (87.8% similar) in 147 aa overlap (10-156:22-167) 10 20 30 40 pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALIS : :.:.:.:..::.:: :.:.::::.: ..:::.:.:. NP_062 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 CRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFY :.. :.::. ::.:::::... ..::.: :::.::::::::. :::::.:::::: :::: NP_062 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY 70 80 90 100 110 120 110 120 130 140 150 pF1KE1 HSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF ....::.::.:::::: :::: ::. :.:::.::::. .: : :.. NP_062 RAKTGRTSTLESVAFPDWFIA-SSKRDQPIILTSELGKSYNTAFELNIND 130 140 150 160 >>XP_011509264 (OMIM: 605508) PREDICTED: interleukin-36 (157 aa) initn: 504 init1: 484 opt: 502 Z-score: 671.7 bits: 130.5 E(85289): 1.1e-30 Smith-Waterman score: 502; 49.0% identity (80.0% similar) in 145 aa overlap (10-154:9-153) 10 20 30 40 50 60 pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG :. .:.: . ::::. ..:::.: . ..:::. ::.:: .: .:..: XP_011 MNPQREAAPKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLHLIACRDTEFSDKEKG 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES : .:::..: .:::.::.. .::::::::.::::: . . : :::.:.. : .:.:.: XP_011 NMVYLGIKGKDLCLFCAEIQGKPTLQLKEKNIMDLYVEKKAQKPFLFFHNKEGSTSVFQS 60 70 80 90 100 110 130 140 150 pF1KE1 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF :..::::::.:. .: :..::.: : .:.:.: : XP_011 VSYPGWFIATSTTSGQPIFLTKERGITNNTNFYLDSVE 120 130 140 150 >>NP_775270 (OMIM: 605508) interleukin-36 beta isoform 2 (157 aa) initn: 504 init1: 484 opt: 502 Z-score: 671.7 bits: 130.5 E(85289): 1.1e-30 Smith-Waterman score: 502; 49.0% identity (80.0% similar) in 145 aa overlap (10-154:9-153) 10 20 30 40 50 60 pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRG :. .:.: . ::::. ..:::.: . ..:::. ::.:: .: .:..: NP_775 MNPQREAAPKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLHLIACRDTEFSDKEKG 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 NPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFES : .:::..: .:::.::.. .::::::::.::::: . . : :::.:.. : .:.:.: NP_775 NMVYLGIKGKDLCLFCAEIQGKPTLQLKEKNIMDLYVEKKAQKPFLFFHNKEGSTSVFQS 60 70 80 90 100 110 130 140 150 pF1KE1 VAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF :..::::::.:. .: :..::.: : .:.:.: : NP_775 VSYPGWFIATSTTSGQPIFLTKERGITNNTNFYLDSVE 120 130 140 150 >>NP_001265497 (OMIM: 605542) interleukin-36 gamma isofo (134 aa) initn: 482 init1: 426 opt: 481 Z-score: 644.9 bits: 125.3 E(85289): 3.5e-29 Smith-Waterman score: 481; 60.9% identity (87.8% similar) in 115 aa overlap (42-156:19-132) 20 30 40 50 60 70 pF1KE1 RGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRGNPIYLGLNGLN .:.:.:.:.. :.::. ::.:::::... . NP_001 MRGTPGDADGGGRAVYQSITVAVITCKYPEALEQGRGDPIYLGIQNPE 10 20 30 40 80 90 100 110 120 130 pF1KE1 LCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFESVAFPGWFIAVS .::.: :::.::::::::. :::::.:::::: ::::....::.::.:::::: :::: : NP_001 MCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFYRAKTGRTSTLESVAFPDWFIA-S 50 60 70 80 90 100 140 150 pF1KE1 SEGGCPLILTQELGKANTTDFGLTMLF :. :.:::.::::. .: : :.. NP_001 SKRDQPIILTSELGKSYNTAFELNIND 110 120 130 >>NP_775297 (OMIM: 605510) interleukin-37 isoform 5 [Hom (192 aa) initn: 271 init1: 105 opt: 306 Z-score: 411.2 bits: 82.6 E(85289): 3.6e-16 Smith-Waterman score: 306; 37.6% identity (67.1% similar) in 149 aa overlap (10-154:31-177) 10 20 30 pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRM :.. ::.: .:.: ::.. .::::: :. . NP_775 MSGCDRRETETKGKNSFKKRLRGPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYI 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 SP-VTIALISCRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQ--PTLQLKEKDIMDLY : . .:: : . :: :.:: ::.. ..::.: : : :.::::.. .: : NP_775 RPEIFFALASSLSSASAEK--GSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLA 70 80 90 100 110 100 110 120 130 140 150 pF1KE1 NQPEPVKS-FLFYHSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLT : : .. :.::..: : . .::.: ::::: .: . . :. .:... . . .:.. NP_775 AQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQ 120 130 140 150 160 170 pF1KE1 MLF NP_775 PVCKAEMSPSEVSD 180 190 >>NP_775294 (OMIM: 605510) interleukin-37 isoform 2 [Hom (197 aa) initn: 271 init1: 105 opt: 306 Z-score: 411.1 bits: 82.6 E(85289): 3.7e-16 Smith-Waterman score: 306; 37.6% identity (67.1% similar) in 149 aa overlap (10-154:36-182) 10 20 30 pF1KE1 MEKALKIDTPQRGSIQDINHRVWVLQDQTLIAVPRKDRM :.. ::.: .:.: ::.. .::::: :. . NP_775 ENSGVKMGSEDWEKDEPQCCLEGPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYI 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 SP-VTIALISCRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQ--PTLQLKEKDIMDLY : . .:: : . :: :.:: ::.. ..::.: : : :.::::.. .: : NP_775 RPEIFFALASSLSSASAEK--GSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLA 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 NQPEPVKS-FLFYHSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLT : : .. :.::..: : . .::.: ::::: .: . . :. .:... . . .:.. NP_775 AQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQ 130 140 150 160 170 180 pF1KE1 MLF NP_775 PVCKAEMSPSEVSD 190 158 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 11:01:18 2016 done: Sun Nov 6 11:01:19 2016 Total Scan time: 5.330 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]