FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4082, 429 aa 1>>>pF1KE4082 429 - 429 aa - 429 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1948+/-0.000336; mu= 10.8055+/- 0.021 mean_var=185.3387+/-38.069, 0's: 0 Z-trim(121.4): 117 B-trim: 457 in 2/52 Lambda= 0.094209 statistics sampled from 37907 (38068) to 37907 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.763), E-opt: 0.2 (0.446), width: 16 Scan time: 9.930 The best scores are: opt bits E(85289) NP_859061 (OMIM: 612063) E3 ubiquitin-protein liga ( 429) 2998 419.6 7.9e-117 XP_016861144 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 753 114.4 5.2e-25 XP_011510676 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 753 114.4 5.2e-25 NP_899237 (OMIM: 609247) E3 ubiquitin-protein liga ( 381) 753 114.4 5.2e-25 XP_016861143 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 753 114.4 5.2e-25 NP_009213 (OMIM: 609247) E3 ubiquitin-protein liga ( 381) 753 114.4 5.2e-25 XP_011510675 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 753 114.4 5.2e-25 NP_001307288 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 735 111.9 2.7e-24 NP_056343 (OMIM: 610431) E3 ubiquitin-protein liga ( 350) 735 111.9 2.7e-24 NP_001307286 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 735 111.9 2.7e-24 NP_001307290 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 735 111.9 2.7e-24 NP_001307285 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 735 111.9 2.7e-24 XP_016879916 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 350) 735 111.9 2.7e-24 NP_001307289 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 735 111.9 2.7e-24 NP_001307287 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 735 111.9 2.7e-24 NP_001307291 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 704 107.6 4.6e-23 NP_001307292 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 704 107.6 4.6e-23 NP_001307293 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 704 107.6 4.6e-23 NP_001307294 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 704 107.6 4.6e-23 XP_016861149 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 250) 396 65.7 1.6e-10 XP_005247149 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 396 65.7 1.6e-10 XP_016861145 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 396 65.7 1.6e-10 XP_011510678 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 396 65.7 1.6e-10 XP_016861146 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 396 65.7 1.6e-10 XP_016861148 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 396 65.7 1.6e-10 XP_016861147 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 396 65.7 1.6e-10 XP_016861150 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 193) 346 58.7 1.5e-08 XP_016879917 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 227) 311 54.1 4.4e-07 NP_057204 (OMIM: 300379,300978) E3 ubiquitin-prote ( 624) 222 42.4 0.0038 NP_899196 (OMIM: 300379,300978) E3 ubiquitin-prote ( 624) 222 42.4 0.0038 NP_115549 (OMIM: 612062) E3 ubiquitin-protein liga ( 836) 221 42.4 0.0051 XP_011528739 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 221 42.4 0.0052 XP_011528740 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 221 42.4 0.0052 XP_011528737 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 221 42.4 0.0052 XP_011528738 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 221 42.4 0.0052 XP_016884479 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 221 42.4 0.0052 NP_001193927 (OMIM: 612062) E3 ubiquitin-protein l ( 936) 221 42.5 0.0055 NP_001292474 (OMIM: 612482,617108) E3 ubiquitin-pr ( 656) 217 41.8 0.0064 XP_011523258 (OMIM: 612482,617108) PREDICTED: E3 u ( 742) 217 41.8 0.0069 NP_001292473 (OMIM: 612482,617108) E3 ubiquitin-pr ( 783) 217 41.9 0.0072 NP_060233 (OMIM: 612482,617108) E3 ubiquitin-prote ( 783) 217 41.9 0.0072 XP_011523257 (OMIM: 612482,617108) PREDICTED: E3 u ( 869) 217 41.9 0.0077 XP_016880289 (OMIM: 612482,617108) PREDICTED: E3 u ( 869) 217 41.9 0.0077 >>NP_859061 (OMIM: 612063) E3 ubiquitin-protein ligase Z (429 aa) initn: 2998 init1: 2998 opt: 2998 Z-score: 2218.5 bits: 419.6 E(85289): 7.9e-117 Smith-Waterman score: 2998; 99.5% identity (100.0% similar) in 429 aa overlap (1-429:1-429) 10 20 30 40 50 60 pF1KE4 MPLCRPEHLMPRASRVPVAASLPLSHAVIPTQLPSRPGHRPPGRPRRCPKASCLPPPVGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 MPLCRPEHLMPRASRVPVAASLPLSHAVIPTQLPSRPGHRPPGRPRRCPKASCLPPPVGP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 SSTQTAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRAVLEDNSSSVDFADLPALF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 SSTQTAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRAVLEDNSSSVDFADLPALF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GVPLAPEGIRGYLMEVKPANACHPIEAPRLGNRSLGSIALIRRYDCTFDLKVLNAQRAGF ::::::::::::::::::::::::::::::::::::.:.::::::::::::::::::::: NP_859 GVPLAPEGIRGYLMEVKPANACHPIEAPRLGNRSLGAIVLIRRYDCTFDLKVLNAQRAGF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 EAAIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGCNKSAHALLLPDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 EAAIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGCNKSAHALLLPDD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 PPCHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHRRPVKTSTCQKAQVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 PPCHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHRRPVKTSTCQKAQVR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 TFTWHNDLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRRSCPVCKQSVAATED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 TFTWHNDLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRRSCPVCKQSVAATED 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 SFDSTTYSFRDEDPSLPGHRPPIWAIQVQLRSRRLELLGRASPHCHCSTTSLEAEYTTVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 SFDSTTYSFRDEDPSLPGHRPPIWAIQVQLRSRRLELLGRASPHCHCSTTSLEAEYTTVS 370 380 390 400 410 420 pF1KE4 SAPPEAPGQ ::::::::: NP_859 SAPPEAPGQ >>XP_016861144 (OMIM: 609247) PREDICTED: E3 ubiquitin-pr (381 aa) initn: 615 init1: 276 opt: 753 Z-score: 570.1 bits: 114.4 E(85289): 5.2e-25 Smith-Waterman score: 753; 40.8% identity (69.0% similar) in 316 aa overlap (80-389:18-321) 50 60 70 80 90 100 pF1KE4 KASCLPPPVGPSSTQTAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRAVLEDNSS ...:. . :.:: :..: . : .:.: XP_016 MLLSIGMLMLSATQVYTILTVQLFAFLNLL--PVEADILAYNFENAS 10 20 30 40 110 120 130 140 150 160 pF1KE4 SVDFADLPALFGVPLAPEGIRGYLMEVKPANACHPIEAPRLGNRSLGS-IALIRRYDCTF .. : :::: :: : ::..:.:.. :: :::.:: : . . : :. :.:::: ::.: XP_016 QT-FDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSSGTFIVLIRRLDCNF 50 60 70 80 90 100 170 180 190 200 210 220 pF1KE4 DLKVLNAQRAGFEAAIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGC :.:::::::::..::::::: ::::.:: .. .: :::::..:.....:. . XP_016 DIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVFIGESSANSLKDEFTY 110 120 130 140 150 160 230 240 250 260 270 280 pF1KE4 NKSAHALLLPDDPPCHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHRRP .:..: .:.:. . : : . .: : :.: :.. . . .: .: XP_016 EKGGHLILVPEFSLPLEYYLIPFLII---VGICLILIV-IFMITKFVQDRHRA---RRNR 170 180 190 200 210 290 300 310 320 330 340 pF1KE4 VKTSTCQKAQVRTFTWHN--DLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRR .. . .: :. : . :.:::::::::.::.:.::::::.:::::.:::.... .. XP_016 LRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKT-KK 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE4 SCPVCKQSVAATEDSFDSTTYSFRDEDPSLPGHRP---PIWAIQVQLRSRRLELLGRASP .::::::.:. .. . :: : : ..:. . : : :. ....: XP_016 TCPVCKQKVVPSQGDSDSDTDSSQEENE-VTEHTPLLRPLASVSAQSFGALSESRSHQNM 280 290 300 310 320 330 410 420 pF1KE4 HCHCSTTSLEAEYTTVSSAPPEAPGQ XP_016 TESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV 340 350 360 370 380 >>XP_011510676 (OMIM: 609247) PREDICTED: E3 ubiquitin-pr (381 aa) initn: 615 init1: 276 opt: 753 Z-score: 570.1 bits: 114.4 E(85289): 5.2e-25 Smith-Waterman score: 753; 40.8% identity (69.0% similar) in 316 aa overlap (80-389:18-321) 50 60 70 80 90 100 pF1KE4 KASCLPPPVGPSSTQTAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRAVLEDNSS ...:. . :.:: :..: . : .:.: XP_011 MLLSIGMLMLSATQVYTILTVQLFAFLNLL--PVEADILAYNFENAS 10 20 30 40 110 120 130 140 150 160 pF1KE4 SVDFADLPALFGVPLAPEGIRGYLMEVKPANACHPIEAPRLGNRSLGS-IALIRRYDCTF .. : :::: :: : ::..:.:.. :: :::.:: : . . : :. :.:::: ::.: XP_011 QT-FDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSSGTFIVLIRRLDCNF 50 60 70 80 90 100 170 180 190 200 210 220 pF1KE4 DLKVLNAQRAGFEAAIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGC :.:::::::::..::::::: ::::.:: .. .: :::::..:.....:. . XP_011 DIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVFIGESSANSLKDEFTY 110 120 130 140 150 160 230 240 250 260 270 280 pF1KE4 NKSAHALLLPDDPPCHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHRRP .:..: .:.:. . : : . .: : :.: :.. . . .: .: XP_011 EKGGHLILVPEFSLPLEYYLIPFLII---VGICLILIV-IFMITKFVQDRHRA---RRNR 170 180 190 200 210 290 300 310 320 330 340 pF1KE4 VKTSTCQKAQVRTFTWHN--DLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRR .. . .: :. : . :.:::::::::.::.:.::::::.:::::.:::.... .. XP_011 LRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKT-KK 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE4 SCPVCKQSVAATEDSFDSTTYSFRDEDPSLPGHRP---PIWAIQVQLRSRRLELLGRASP .::::::.:. .. . :: : : ..:. . : : :. ....: XP_011 TCPVCKQKVVPSQGDSDSDTDSSQEENE-VTEHTPLLRPLASVSAQSFGALSESRSHQNM 280 290 300 310 320 330 410 420 pF1KE4 HCHCSTTSLEAEYTTVSSAPPEAPGQ XP_011 TESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV 340 350 360 370 380 >>NP_899237 (OMIM: 609247) E3 ubiquitin-protein ligase R (381 aa) initn: 615 init1: 276 opt: 753 Z-score: 570.1 bits: 114.4 E(85289): 5.2e-25 Smith-Waterman score: 753; 40.8% identity (69.0% similar) in 316 aa overlap (80-389:18-321) 50 60 70 80 90 100 pF1KE4 KASCLPPPVGPSSTQTAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRAVLEDNSS ...:. . :.:: :..: . : .:.: NP_899 MLLSIGMLMLSATQVYTILTVQLFAFLNLL--PVEADILAYNFENAS 10 20 30 40 110 120 130 140 150 160 pF1KE4 SVDFADLPALFGVPLAPEGIRGYLMEVKPANACHPIEAPRLGNRSLGS-IALIRRYDCTF .. : :::: :: : ::..:.:.. :: :::.:: : . . : :. :.:::: ::.: NP_899 QT-FDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSSGTFIVLIRRLDCNF 50 60 70 80 90 100 170 180 190 200 210 220 pF1KE4 DLKVLNAQRAGFEAAIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGC :.:::::::::..::::::: ::::.:: .. .: :::::..:.....:. . NP_899 DIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVFIGESSANSLKDEFTY 110 120 130 140 150 160 230 240 250 260 270 280 pF1KE4 NKSAHALLLPDDPPCHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHRRP .:..: .:.:. . : : . .: : :.: :.. . . .: .: NP_899 EKGGHLILVPEFSLPLEYYLIPFLII---VGICLILIV-IFMITKFVQDRHRA---RRNR 170 180 190 200 210 290 300 310 320 330 340 pF1KE4 VKTSTCQKAQVRTFTWHN--DLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRR .. . .: :. : . :.:::::::::.::.:.::::::.:::::.:::.... .. NP_899 LRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKT-KK 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE4 SCPVCKQSVAATEDSFDSTTYSFRDEDPSLPGHRP---PIWAIQVQLRSRRLELLGRASP .::::::.:. .. . :: : : ..:. . : : :. ....: NP_899 TCPVCKQKVVPSQGDSDSDTDSSQEENE-VTEHTPLLRPLASVSAQSFGALSESRSHQNM 280 290 300 310 320 330 410 420 pF1KE4 HCHCSTTSLEAEYTTVSSAPPEAPGQ NP_899 TESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV 340 350 360 370 380 >>XP_016861143 (OMIM: 609247) PREDICTED: E3 ubiquitin-pr (381 aa) initn: 615 init1: 276 opt: 753 Z-score: 570.1 bits: 114.4 E(85289): 5.2e-25 Smith-Waterman score: 753; 40.8% identity (69.0% similar) in 316 aa overlap (80-389:18-321) 50 60 70 80 90 100 pF1KE4 KASCLPPPVGPSSTQTAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRAVLEDNSS ...:. . :.:: :..: . : .:.: XP_016 MLLSIGMLMLSATQVYTILTVQLFAFLNLL--PVEADILAYNFENAS 10 20 30 40 110 120 130 140 150 160 pF1KE4 SVDFADLPALFGVPLAPEGIRGYLMEVKPANACHPIEAPRLGNRSLGS-IALIRRYDCTF .. : :::: :: : ::..:.:.. :: :::.:: : . . : :. :.:::: ::.: XP_016 QT-FDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSSGTFIVLIRRLDCNF 50 60 70 80 90 100 170 180 190 200 210 220 pF1KE4 DLKVLNAQRAGFEAAIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGC :.:::::::::..::::::: ::::.:: .. .: :::::..:.....:. . XP_016 DIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVFIGESSANSLKDEFTY 110 120 130 140 150 160 230 240 250 260 270 280 pF1KE4 NKSAHALLLPDDPPCHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHRRP .:..: .:.:. . : : . .: : :.: :.. . . .: .: XP_016 EKGGHLILVPEFSLPLEYYLIPFLII---VGICLILIV-IFMITKFVQDRHRA---RRNR 170 180 190 200 210 290 300 310 320 330 340 pF1KE4 VKTSTCQKAQVRTFTWHN--DLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRR .. . .: :. : . :.:::::::::.::.:.::::::.:::::.:::.... .. XP_016 LRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKT-KK 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE4 SCPVCKQSVAATEDSFDSTTYSFRDEDPSLPGHRP---PIWAIQVQLRSRRLELLGRASP .::::::.:. .. . :: : : ..:. . : : :. ....: XP_016 TCPVCKQKVVPSQGDSDSDTDSSQEENE-VTEHTPLLRPLASVSAQSFGALSESRSHQNM 280 290 300 310 320 330 410 420 pF1KE4 HCHCSTTSLEAEYTTVSSAPPEAPGQ XP_016 TESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV 340 350 360 370 380 >>NP_009213 (OMIM: 609247) E3 ubiquitin-protein ligase R (381 aa) initn: 615 init1: 276 opt: 753 Z-score: 570.1 bits: 114.4 E(85289): 5.2e-25 Smith-Waterman score: 753; 40.8% identity (69.0% similar) in 316 aa overlap (80-389:18-321) 50 60 70 80 90 100 pF1KE4 KASCLPPPVGPSSTQTAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRAVLEDNSS ...:. . :.:: :..: . : .:.: NP_009 MLLSIGMLMLSATQVYTILTVQLFAFLNLL--PVEADILAYNFENAS 10 20 30 40 110 120 130 140 150 160 pF1KE4 SVDFADLPALFGVPLAPEGIRGYLMEVKPANACHPIEAPRLGNRSLGS-IALIRRYDCTF .. : :::: :: : ::..:.:.. :: :::.:: : . . : :. :.:::: ::.: NP_009 QT-FDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSSGTFIVLIRRLDCNF 50 60 70 80 90 100 170 180 190 200 210 220 pF1KE4 DLKVLNAQRAGFEAAIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGC :.:::::::::..::::::: ::::.:: .. .: :::::..:.....:. . NP_009 DIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVFIGESSANSLKDEFTY 110 120 130 140 150 160 230 240 250 260 270 280 pF1KE4 NKSAHALLLPDDPPCHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHRRP .:..: .:.:. . : : . .: : :.: :.. . . .: .: NP_009 EKGGHLILVPEFSLPLEYYLIPFLII---VGICLILIV-IFMITKFVQDRHRA---RRNR 170 180 190 200 210 290 300 310 320 330 340 pF1KE4 VKTSTCQKAQVRTFTWHN--DLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRR .. . .: :. : . :.:::::::::.::.:.::::::.:::::.:::.... .. NP_009 LRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKT-KK 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE4 SCPVCKQSVAATEDSFDSTTYSFRDEDPSLPGHRP---PIWAIQVQLRSRRLELLGRASP .::::::.:. .. . :: : : ..:. . : : :. ....: NP_009 TCPVCKQKVVPSQGDSDSDTDSSQEENE-VTEHTPLLRPLASVSAQSFGALSESRSHQNM 280 290 300 310 320 330 410 420 pF1KE4 HCHCSTTSLEAEYTTVSSAPPEAPGQ NP_009 TESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV 340 350 360 370 380 >>XP_011510675 (OMIM: 609247) PREDICTED: E3 ubiquitin-pr (381 aa) initn: 615 init1: 276 opt: 753 Z-score: 570.1 bits: 114.4 E(85289): 5.2e-25 Smith-Waterman score: 753; 40.8% identity (69.0% similar) in 316 aa overlap (80-389:18-321) 50 60 70 80 90 100 pF1KE4 KASCLPPPVGPSSTQTAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRAVLEDNSS ...:. . :.:: :..: . : .:.: XP_011 MLLSIGMLMLSATQVYTILTVQLFAFLNLL--PVEADILAYNFENAS 10 20 30 40 110 120 130 140 150 160 pF1KE4 SVDFADLPALFGVPLAPEGIRGYLMEVKPANACHPIEAPRLGNRSLGS-IALIRRYDCTF .. : :::: :: : ::..:.:.. :: :::.:: : . . : :. :.:::: ::.: XP_011 QT-FDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSSGTFIVLIRRLDCNF 50 60 70 80 90 100 170 180 190 200 210 220 pF1KE4 DLKVLNAQRAGFEAAIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGC :.:::::::::..::::::: ::::.:: .. .: :::::..:.....:. . XP_011 DIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVFIGESSANSLKDEFTY 110 120 130 140 150 160 230 240 250 260 270 280 pF1KE4 NKSAHALLLPDDPPCHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHRRP .:..: .:.:. . : : . .: : :.: :.. . . .: .: XP_011 EKGGHLILVPEFSLPLEYYLIPFLII---VGICLILIV-IFMITKFVQDRHRA---RRNR 170 180 190 200 210 290 300 310 320 330 340 pF1KE4 VKTSTCQKAQVRTFTWHN--DLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRR .. . .: :. : . :.:::::::::.::.:.::::::.:::::.:::.... .. XP_011 LRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKT-KK 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE4 SCPVCKQSVAATEDSFDSTTYSFRDEDPSLPGHRP---PIWAIQVQLRSRRLELLGRASP .::::::.:. .. . :: : : ..:. . : : :. ....: XP_011 TCPVCKQKVVPSQGDSDSDTDSSQEENE-VTEHTPLLRPLASVSAQSFGALSESRSHQNM 280 290 300 310 320 330 410 420 pF1KE4 HCHCSTTSLEAEYTTVSSAPPEAPGQ XP_011 TESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV 340 350 360 370 380 >>NP_001307288 (OMIM: 610431) E3 ubiquitin-protein ligas (350 aa) initn: 747 init1: 300 opt: 735 Z-score: 557.3 bits: 111.9 E(85289): 2.7e-24 Smith-Waterman score: 785; 39.7% identity (67.5% similar) in 348 aa overlap (95-427:21-342) 70 80 90 100 110 120 pF1KE4 TAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRAVLEDNSSSVDFADLPALFGVPL :.....::. :...:.::::::::::. : NP_001 MHPAAFPLPVVVAAVLWGAAPTRGLIRAT-SDHNASMDFADLPALFGATL 10 20 30 40 130 140 150 160 170 180 pF1KE4 APEGIRGYLMEVKPANACHPIEAPRLGNRSLGS--IALIRRYDCTFDLKVLNAQRAGFEA . ::..:.:.:..: ::: :: : . . :: :::.::.::.:::::::::.::. : NP_001 SQEGLQGFLVEAHPDNACSPIAPPPPAPVN-GSVFIALLRRFDCNFDLKVLNAQKAGYGA 50 60 70 80 90 100 190 200 210 220 230 240 pF1KE4 AIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGCNKSAHALLLPDDPP :.::::.:..:..:. :... :: :::::..: .:. ::... .:.:..::.::. NP_001 AVVHNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSSEYLRALFVYEKGARVLLVPDNT- 110 120 130 140 150 160 250 260 270 280 290 300 pF1KE4 CHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHRRPVKTSTCQKAQVRTF :: . .. . ..: :.:...: .. : .::. .. . : :.. . NP_001 -FPLGYY-LIPFTGIVG-LLVLAMGAVMI--------ARCIQHRKRLQRNRLTKEQLKQI 170 180 190 200 210 310 320 330 340 350 pF1KE4 TWHN-------DLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRRSCPVCKQSV :. :.:::::::::.::.:..:::.:.:: .:.:::..:. :..::.::: : NP_001 PTHDYQKGDQYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVDPWLTQT-RKTCPICKQPV 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE4 ---AATEDSFDSTTYSFRDEDPSLPGHRPPIWAIQVQLRSRRLELLGRASPHCHCSTTSL . ::. . : . .. : . : .: :.: ::: .:: : :: NP_001 HRGPGDEDQ-EEETQGQEEGDEGEPRDHPA---------SERTPLLG-SSPTLPTSFGSL 280 290 300 310 320 420 pF1KE4 EAE---YTTVSSAPPEAPGQ . :. :: .: NP_001 APAPLVFPGPSTDPPLSPPSSPVILV 330 340 350 >>NP_056343 (OMIM: 610431) E3 ubiquitin-protein ligase R (350 aa) initn: 747 init1: 300 opt: 735 Z-score: 557.3 bits: 111.9 E(85289): 2.7e-24 Smith-Waterman score: 785; 39.7% identity (67.5% similar) in 348 aa overlap (95-427:21-342) 70 80 90 100 110 120 pF1KE4 TAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRAVLEDNSSSVDFADLPALFGVPL :.....::. :...:.::::::::::. : NP_056 MHPAAFPLPVVVAAVLWGAAPTRGLIRAT-SDHNASMDFADLPALFGATL 10 20 30 40 130 140 150 160 170 180 pF1KE4 APEGIRGYLMEVKPANACHPIEAPRLGNRSLGS--IALIRRYDCTFDLKVLNAQRAGFEA . ::..:.:.:..: ::: :: : . . :: :::.::.::.:::::::::.::. : NP_056 SQEGLQGFLVEAHPDNACSPIAPPPPAPVN-GSVFIALLRRFDCNFDLKVLNAQKAGYGA 50 60 70 80 90 100 190 200 210 220 230 240 pF1KE4 AIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGCNKSAHALLLPDDPP :.::::.:..:..:. :... :: :::::..: .:. ::... .:.:..::.::. NP_056 AVVHNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSSEYLRALFVYEKGARVLLVPDNT- 110 120 130 140 150 160 250 260 270 280 290 300 pF1KE4 CHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHRRPVKTSTCQKAQVRTF :: . .. . ..: :.:...: .. : .::. .. . : :.. . NP_056 -FPLGYY-LIPFTGIVG-LLVLAMGAVMI--------ARCIQHRKRLQRNRLTKEQLKQI 170 180 190 200 210 310 320 330 340 350 pF1KE4 TWHN-------DLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRRSCPVCKQSV :. :.:::::::::.::.:..:::.:.:: .:.:::..:. :..::.::: : NP_056 PTHDYQKGDQYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVDPWLTQT-RKTCPICKQPV 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE4 ---AATEDSFDSTTYSFRDEDPSLPGHRPPIWAIQVQLRSRRLELLGRASPHCHCSTTSL . ::. . : . .. : . : .: :.: ::: .:: : :: NP_056 HRGPGDEDQ-EEETQGQEEGDEGEPRDHPA---------SERTPLLG-SSPTLPTSFGSL 280 290 300 310 320 420 pF1KE4 EAE---YTTVSSAPPEAPGQ . :. :: .: NP_056 APAPLVFPGPSTDPPLSPPSSPVILV 330 340 350 >>NP_001307286 (OMIM: 610431) E3 ubiquitin-protein ligas (350 aa) initn: 747 init1: 300 opt: 735 Z-score: 557.3 bits: 111.9 E(85289): 2.7e-24 Smith-Waterman score: 785; 39.7% identity (67.5% similar) in 348 aa overlap (95-427:21-342) 70 80 90 100 110 120 pF1KE4 TAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRAVLEDNSSSVDFADLPALFGVPL :.....::. :...:.::::::::::. : NP_001 MHPAAFPLPVVVAAVLWGAAPTRGLIRAT-SDHNASMDFADLPALFGATL 10 20 30 40 130 140 150 160 170 180 pF1KE4 APEGIRGYLMEVKPANACHPIEAPRLGNRSLGS--IALIRRYDCTFDLKVLNAQRAGFEA . ::..:.:.:..: ::: :: : . . :: :::.::.::.:::::::::.::. : NP_001 SQEGLQGFLVEAHPDNACSPIAPPPPAPVN-GSVFIALLRRFDCNFDLKVLNAQKAGYGA 50 60 70 80 90 100 190 200 210 220 230 240 pF1KE4 AIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGCNKSAHALLLPDDPP :.::::.:..:..:. :... :: :::::..: .:. ::... .:.:..::.::. NP_001 AVVHNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSSEYLRALFVYEKGARVLLVPDNT- 110 120 130 140 150 160 250 260 270 280 290 300 pF1KE4 CHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHRRPVKTSTCQKAQVRTF :: . .. . ..: :.:...: .. : .::. .. . : :.. . NP_001 -FPLGYY-LIPFTGIVG-LLVLAMGAVMI--------ARCIQHRKRLQRNRLTKEQLKQI 170 180 190 200 210 310 320 330 340 350 pF1KE4 TWHN-------DLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRRSCPVCKQSV :. :.:::::::::.::.:..:::.:.:: .:.:::..:. :..::.::: : NP_001 PTHDYQKGDQYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVDPWLTQT-RKTCPICKQPV 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE4 ---AATEDSFDSTTYSFRDEDPSLPGHRPPIWAIQVQLRSRRLELLGRASPHCHCSTTSL . ::. . : . .. : . : .: :.: ::: .:: : :: NP_001 HRGPGDEDQ-EEETQGQEEGDEGEPRDHPA---------SERTPLLG-SSPTLPTSFGSL 280 290 300 310 320 420 pF1KE4 EAE---YTTVSSAPPEAPGQ . :. :: .: NP_001 APAPLVFPGPSTDPPLSPPSSPVILV 330 340 350 429 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 02:08:29 2016 done: Tue Nov 8 02:08:30 2016 Total Scan time: 9.930 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]