FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3223, 506 aa 1>>>pF1KE3223 506 - 506 aa - 506 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2291+/-0.000413; mu= 9.0381+/- 0.026 mean_var=108.0416+/-21.840, 0's: 0 Z-trim(113.7): 32 B-trim: 695 in 1/52 Lambda= 0.123390 statistics sampled from 23145 (23174) to 23145 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.633), E-opt: 0.2 (0.272), width: 16 Scan time: 9.210 The best scores are: opt bits E(85289) NP_788276 (OMIM: 608202) CDK5 regulatory subunit-a ( 506) 3268 592.8 7.7e-169 XP_011523599 (OMIM: 608202) PREDICTED: CDK5 regula ( 531) 3256 590.7 3.5e-168 NP_001265126 (OMIM: 608202) CDK5 regulatory subuni ( 531) 3256 590.7 3.5e-168 XP_016880655 (OMIM: 608202) PREDICTED: CDK5 regula ( 413) 2647 482.2 1.2e-135 NP_001265146 (OMIM: 608202) CDK5 regulatory subuni ( 419) 2526 460.7 3.8e-129 XP_016880654 (OMIM: 608202) PREDICTED: CDK5 regula ( 419) 2526 460.7 3.8e-129 XP_016880653 (OMIM: 608202) PREDICTED: CDK5 regula ( 419) 2526 460.7 3.8e-129 NP_001265145 (OMIM: 608202) CDK5 regulatory subuni ( 281) 1788 329.3 9.3e-90 NP_001265127 (OMIM: 608202) CDK5 regulatory subuni ( 316) 1707 314.9 2.3e-85 >>NP_788276 (OMIM: 608202) CDK5 regulatory subunit-assoc (506 aa) initn: 3268 init1: 3268 opt: 3268 Z-score: 3152.2 bits: 592.8 E(85289): 7.7e-169 Smith-Waterman score: 3268; 100.0% identity (100.0% similar) in 506 aa overlap (1-506:1-506) 10 20 30 40 50 60 pF1KE3 MEDHQHVPIDIQTSKLLDWLVDRRHCSLKWQSLVLTIREKINAAIQDMPESEEIAQLLSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_788 MEDHQHVPIDIQTSKLLDWLVDRRHCSLKWQSLVLTIREKINAAIQDMPESEEIAQLLSG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 SYIHYFHCLRILDLLKGTEASTKNIFGRYSSQRMKDWQEIIALYEKDNTYLVELSSLLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_788 SYIHYFHCLRILDLLKGTEASTKNIFGRYSSQRMKDWQEIIALYEKDNTYLVELSSLLVR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 NVNYEIPSLKKQIAKCQQLQQEYSRKEEECQAGAAEMREQFYHSCKQYGITGENVRGELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_788 NVNYEIPSLKKQIAKCQQLQQEYSRKEEECQAGAAEMREQFYHSCKQYGITGENVRGELL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 ALVKDLPSQLAEIGAAAQQSLGEAIDVYQASVGFVCESPTEQVLPMLRFVQKRGNSTVYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_788 ALVKDLPSQLAEIGAAAQQSLGEAIDVYQASVGFVCESPTEQVLPMLRFVQKRGNSTVYE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 WRTGTEPSVVERPHLEELPEQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_788 WRTGTEPSVVERPHLEELPEQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPES 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DSKDPGGDGIDWGDDAVALQITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_788 DSKDPGGDGIDWGDDAVALQITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EIFLAQRAVELSEEADVLSVSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_788 EIFLAQRAVELSEEADVLSVSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 FMILASPRYVDRVTEFLQQKLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_788 FMILASPRYVDRVTEFLQQKLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTK 430 440 450 460 470 480 490 500 pF1KE3 ELQKLIEADISKRYSGRPVNLMGTSL :::::::::::::::::::::::::: NP_788 ELQKLIEADISKRYSGRPVNLMGTSL 490 500 >>XP_011523599 (OMIM: 608202) PREDICTED: CDK5 regulatory (531 aa) initn: 3256 init1: 3256 opt: 3256 Z-score: 3140.3 bits: 590.7 E(85289): 3.5e-168 Smith-Waterman score: 3256; 99.8% identity (100.0% similar) in 505 aa overlap (2-506:27-531) 10 20 30 pF1KE3 MEDHQHVPIDIQTSKLLDWLVDRRHCSLKWQSLVL .::::::::::::::::::::::::::::::::: XP_011 MRRQSMTSATRDLHTALDGKATQGGKKDHQHVPIDIQTSKLLDWLVDRRHCSLKWQSLVL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 TIREKINAAIQDMPESEEIAQLLSGSYIHYFHCLRILDLLKGTEASTKNIFGRYSSQRMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TIREKINAAIQDMPESEEIAQLLSGSYIHYFHCLRILDLLKGTEASTKNIFGRYSSQRMK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 DWQEIIALYEKDNTYLVELSSLLVRNVNYEIPSLKKQIAKCQQLQQEYSRKEEECQAGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DWQEIIALYEKDNTYLVELSSLLVRNVNYEIPSLKKQIAKCQQLQQEYSRKEEECQAGAA 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 EMREQFYHSCKQYGITGENVRGELLALVKDLPSQLAEIGAAAQQSLGEAIDVYQASVGFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EMREQFYHSCKQYGITGENVRGELLALVKDLPSQLAEIGAAAQQSLGEAIDVYQASVGFV 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 CESPTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERPHLEELPEQVAEDAIDWGDFGVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CESPTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERPHLEELPEQVAEDAIDWGDFGVE 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 AVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDDAVALQITVLEAGTQAPEGVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDDAVALQITVLEAGTQAPEGVA 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 RGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEADVLSVSQFQLAPAILQGQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEADVLSVSQFQLAPAILQGQTK 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE3 EKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQKLKQSQLLALKKELMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQKLKQSQLLALKKELMV 430 440 450 460 470 480 460 470 480 490 500 pF1KE3 QKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYSGRPVNLMGTSL ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYSGRPVNLMGTSL 490 500 510 520 530 >>NP_001265126 (OMIM: 608202) CDK5 regulatory subunit-as (531 aa) initn: 3256 init1: 3256 opt: 3256 Z-score: 3140.3 bits: 590.7 E(85289): 3.5e-168 Smith-Waterman score: 3256; 99.8% identity (100.0% similar) in 505 aa overlap (2-506:27-531) 10 20 30 pF1KE3 MEDHQHVPIDIQTSKLLDWLVDRRHCSLKWQSLVL .::::::::::::::::::::::::::::::::: NP_001 MRRQSMTSATRDLHTALDGKATQGGKKDHQHVPIDIQTSKLLDWLVDRRHCSLKWQSLVL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 TIREKINAAIQDMPESEEIAQLLSGSYIHYFHCLRILDLLKGTEASTKNIFGRYSSQRMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIREKINAAIQDMPESEEIAQLLSGSYIHYFHCLRILDLLKGTEASTKNIFGRYSSQRMK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 DWQEIIALYEKDNTYLVELSSLLVRNVNYEIPSLKKQIAKCQQLQQEYSRKEEECQAGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DWQEIIALYEKDNTYLVELSSLLVRNVNYEIPSLKKQIAKCQQLQQEYSRKEEECQAGAA 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 EMREQFYHSCKQYGITGENVRGELLALVKDLPSQLAEIGAAAQQSLGEAIDVYQASVGFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EMREQFYHSCKQYGITGENVRGELLALVKDLPSQLAEIGAAAQQSLGEAIDVYQASVGFV 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 CESPTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERPHLEELPEQVAEDAIDWGDFGVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CESPTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERPHLEELPEQVAEDAIDWGDFGVE 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 AVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDDAVALQITVLEAGTQAPEGVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDDAVALQITVLEAGTQAPEGVA 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 RGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEADVLSVSQFQLAPAILQGQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEADVLSVSQFQLAPAILQGQTK 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE3 EKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQKLKQSQLLALKKELMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQKLKQSQLLALKKELMV 430 440 450 460 470 480 460 470 480 490 500 pF1KE3 QKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYSGRPVNLMGTSL ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYSGRPVNLMGTSL 490 500 510 520 530 >>XP_016880655 (OMIM: 608202) PREDICTED: CDK5 regulatory (413 aa) initn: 2647 init1: 2647 opt: 2647 Z-score: 2556.2 bits: 482.2 E(85289): 1.2e-135 Smith-Waterman score: 2647; 100.0% identity (100.0% similar) in 413 aa overlap (94-506:1-413) 70 80 90 100 110 120 pF1KE3 HYFHCLRILDLLKGTEASTKNIFGRYSSQRMKDWQEIIALYEKDNTYLVELSSLLVRNVN :::::::::::::::::::::::::::::: XP_016 MKDWQEIIALYEKDNTYLVELSSLLVRNVN 10 20 30 130 140 150 160 170 180 pF1KE3 YEIPSLKKQIAKCQQLQQEYSRKEEECQAGAAEMREQFYHSCKQYGITGENVRGELLALV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YEIPSLKKQIAKCQQLQQEYSRKEEECQAGAAEMREQFYHSCKQYGITGENVRGELLALV 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE3 KDLPSQLAEIGAAAQQSLGEAIDVYQASVGFVCESPTEQVLPMLRFVQKRGNSTVYEWRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDLPSQLAEIGAAAQQSLGEAIDVYQASVGFVCESPTEQVLPMLRFVQKRGNSTVYEWRT 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE3 GTEPSVVERPHLEELPEQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPESDSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTEPSVVERPHLEELPEQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPESDSK 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE3 DPGGDGIDWGDDAVALQITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMELEIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPGGDGIDWGDDAVALQITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMELEIF 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE3 LAQRAVELSEEADVLSVSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHLFMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAQRAVELSEEADVLSVSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHLFMI 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE3 LASPRYVDRVTEFLQQKLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTKELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LASPRYVDRVTEFLQQKLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTKELQ 340 350 360 370 380 390 490 500 pF1KE3 KLIEADISKRYSGRPVNLMGTSL ::::::::::::::::::::::: XP_016 KLIEADISKRYSGRPVNLMGTSL 400 410 >>NP_001265146 (OMIM: 608202) CDK5 regulatory subunit-as (419 aa) initn: 2526 init1: 2526 opt: 2526 Z-score: 2439.6 bits: 460.7 E(85289): 3.8e-129 Smith-Waterman score: 2526; 99.5% identity (99.7% similar) in 397 aa overlap (110-506:23-419) 80 90 100 110 120 130 pF1KE3 ASTKNIFGRYSSQRMKDWQEIIALYEKDNTYLVELSSLLVRNVNYEIPSLKKQIAKCQQL . :::::::::::::::::::::::::::: NP_001 MCVHPGACLPHVGVSWAEFPGHFSVELSSLLVRNVNYEIPSLKKQIAKCQQL 10 20 30 40 50 140 150 160 170 180 190 pF1KE3 QQEYSRKEEECQAGAAEMREQFYHSCKQYGITGENVRGELLALVKDLPSQLAEIGAAAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQEYSRKEEECQAGAAEMREQFYHSCKQYGITGENVRGELLALVKDLPSQLAEIGAAAQQ 60 70 80 90 100 110 200 210 220 230 240 250 pF1KE3 SLGEAIDVYQASVGFVCESPTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERPHLEELP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLGEAIDVYQASVGFVCESPTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERPHLEELP 120 130 140 150 160 170 260 270 280 290 300 310 pF1KE3 EQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDDAVAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDDAVAL 180 190 200 210 220 230 320 330 340 350 360 370 pF1KE3 QITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEADVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEADVLS 240 250 260 270 280 290 380 390 400 410 420 430 pF1KE3 VSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQ 300 310 320 330 340 350 440 450 460 470 480 490 pF1KE3 KLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYSGRPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYSGRPV 360 370 380 390 400 410 500 pF1KE3 NLMGTSL ::::::: NP_001 NLMGTSL >>XP_016880654 (OMIM: 608202) PREDICTED: CDK5 regulatory (419 aa) initn: 2526 init1: 2526 opt: 2526 Z-score: 2439.6 bits: 460.7 E(85289): 3.8e-129 Smith-Waterman score: 2526; 99.5% identity (99.7% similar) in 397 aa overlap (110-506:23-419) 80 90 100 110 120 130 pF1KE3 ASTKNIFGRYSSQRMKDWQEIIALYEKDNTYLVELSSLLVRNVNYEIPSLKKQIAKCQQL . :::::::::::::::::::::::::::: XP_016 MCVHPGACLPHVGVSWAEFPGHFSVELSSLLVRNVNYEIPSLKKQIAKCQQL 10 20 30 40 50 140 150 160 170 180 190 pF1KE3 QQEYSRKEEECQAGAAEMREQFYHSCKQYGITGENVRGELLALVKDLPSQLAEIGAAAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQEYSRKEEECQAGAAEMREQFYHSCKQYGITGENVRGELLALVKDLPSQLAEIGAAAQQ 60 70 80 90 100 110 200 210 220 230 240 250 pF1KE3 SLGEAIDVYQASVGFVCESPTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERPHLEELP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLGEAIDVYQASVGFVCESPTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERPHLEELP 120 130 140 150 160 170 260 270 280 290 300 310 pF1KE3 EQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDDAVAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDDAVAL 180 190 200 210 220 230 320 330 340 350 360 370 pF1KE3 QITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEADVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEADVLS 240 250 260 270 280 290 380 390 400 410 420 430 pF1KE3 VSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQ 300 310 320 330 340 350 440 450 460 470 480 490 pF1KE3 KLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYSGRPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYSGRPV 360 370 380 390 400 410 500 pF1KE3 NLMGTSL ::::::: XP_016 NLMGTSL >>XP_016880653 (OMIM: 608202) PREDICTED: CDK5 regulatory (419 aa) initn: 2526 init1: 2526 opt: 2526 Z-score: 2439.6 bits: 460.7 E(85289): 3.8e-129 Smith-Waterman score: 2526; 99.5% identity (99.7% similar) in 397 aa overlap (110-506:23-419) 80 90 100 110 120 130 pF1KE3 ASTKNIFGRYSSQRMKDWQEIIALYEKDNTYLVELSSLLVRNVNYEIPSLKKQIAKCQQL . :::::::::::::::::::::::::::: XP_016 MCVHPGACLPHVGVSWAEFPGHFSVELSSLLVRNVNYEIPSLKKQIAKCQQL 10 20 30 40 50 140 150 160 170 180 190 pF1KE3 QQEYSRKEEECQAGAAEMREQFYHSCKQYGITGENVRGELLALVKDLPSQLAEIGAAAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQEYSRKEEECQAGAAEMREQFYHSCKQYGITGENVRGELLALVKDLPSQLAEIGAAAQQ 60 70 80 90 100 110 200 210 220 230 240 250 pF1KE3 SLGEAIDVYQASVGFVCESPTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERPHLEELP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLGEAIDVYQASVGFVCESPTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERPHLEELP 120 130 140 150 160 170 260 270 280 290 300 310 pF1KE3 EQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDDAVAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDDAVAL 180 190 200 210 220 230 320 330 340 350 360 370 pF1KE3 QITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEADVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEADVLS 240 250 260 270 280 290 380 390 400 410 420 430 pF1KE3 VSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQ 300 310 320 330 340 350 440 450 460 470 480 490 pF1KE3 KLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYSGRPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYSGRPV 360 370 380 390 400 410 500 pF1KE3 NLMGTSL ::::::: XP_016 NLMGTSL >>NP_001265145 (OMIM: 608202) CDK5 regulatory subunit-as (281 aa) initn: 1788 init1: 1788 opt: 1788 Z-score: 1732.4 bits: 329.3 E(85289): 9.3e-90 Smith-Waterman score: 1788; 100.0% identity (100.0% similar) in 281 aa overlap (226-506:1-281) 200 210 220 230 240 250 pF1KE3 AAQQSLGEAIDVYQASVGFVCESPTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERPHL :::::::::::::::::::::::::::::: NP_001 MLRFVQKRGNSTVYEWRTGTEPSVVERPHL 10 20 30 260 270 280 290 300 310 pF1KE3 EELPEQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EELPEQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDD 40 50 60 70 80 90 320 330 340 350 360 370 pF1KE3 AVALQITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVALQITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEA 100 110 120 130 140 150 380 390 400 410 420 430 pF1KE3 DVLSVSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVLSVSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTE 160 170 180 190 200 210 440 450 460 470 480 490 pF1KE3 FLQQKLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLQQKLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYS 220 230 240 250 260 270 500 pF1KE3 GRPVNLMGTSL ::::::::::: NP_001 GRPVNLMGTSL 280 >>NP_001265127 (OMIM: 608202) CDK5 regulatory subunit-as (316 aa) initn: 1786 init1: 1707 opt: 1707 Z-score: 1653.7 bits: 314.9 E(85289): 2.3e-85 Smith-Waterman score: 1707; 98.9% identity (99.3% similar) in 272 aa overlap (226-497:1-272) 200 210 220 230 240 250 pF1KE3 AAQQSLGEAIDVYQASVGFVCESPTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERPHL :::::::::::::::::::::::::::::: NP_001 MLRFVQKRGNSTVYEWRTGTEPSVVERPHL 10 20 30 260 270 280 290 300 310 pF1KE3 EELPEQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EELPEQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDD 40 50 60 70 80 90 320 330 340 350 360 370 pF1KE3 AVALQITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVALQITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEA 100 110 120 130 140 150 380 390 400 410 420 430 pF1KE3 DVLSVSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVLSVSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTE 160 170 180 190 200 210 440 450 460 470 480 490 pF1KE3 FLQQKLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: . NP_001 FLQQKLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRQK 220 230 240 250 260 270 500 pF1KE3 GRPVNLMGTSL : NP_001 TRLTGRWKATGRKRHLMVILALSMFSTRSCGDWPCGLSGENHRFSF 280 290 300 310 506 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 06:01:23 2016 done: Sun Nov 6 06:01:25 2016 Total Scan time: 9.210 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]