FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4143, 569 aa 1>>>pF1KE4143 569 - 569 aa - 569 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.2269+/-0.000436; mu= -8.3419+/- 0.027 mean_var=348.7885+/-73.644, 0's: 0 Z-trim(121.2): 88 B-trim: 626 in 2/54 Lambda= 0.068674 statistics sampled from 37419 (37512) to 37419 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.758), E-opt: 0.2 (0.44), width: 16 Scan time: 12.740 The best scores are: opt bits E(85289) NP_079092 (OMIM: 611869) rab GTPase-binding effect ( 569) 3596 370.4 8.9e-102 NP_001077054 (OMIM: 603616) rab GTPase-binding eff ( 829) 593 73.0 4.4e-12 XP_016880784 (OMIM: 603616) PREDICTED: rab GTPase- ( 552) 397 53.4 2.2e-06 XP_016880783 (OMIM: 603616) PREDICTED: rab GTPase- ( 574) 397 53.4 2.3e-06 NP_001278510 (OMIM: 603616) rab GTPase-binding eff ( 819) 397 53.5 3e-06 NP_004694 (OMIM: 603616) rab GTPase-binding effect ( 862) 397 53.6 3.1e-06 XP_011522362 (OMIM: 603616) PREDICTED: rab GTPase- ( 884) 397 53.6 3.2e-06 NP_001278511 (OMIM: 603616) rab GTPase-binding eff ( 190) 305 43.9 0.00054 >>NP_079092 (OMIM: 611869) rab GTPase-binding effector p (569 aa) initn: 3596 init1: 3596 opt: 3596 Z-score: 1948.2 bits: 370.4 E(85289): 8.9e-102 Smith-Waterman score: 3596; 99.8% identity (100.0% similar) in 569 aa overlap (1-569:1-569) 10 20 30 40 50 60 pF1KE4 MAAAAPVAADDDERRRRPGSALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAV :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: NP_079 MAAAAPVAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 AEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 AEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 ELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 QRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 QRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 GGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 QLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 QLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 LQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 LCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEAS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 LCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLE 490 500 510 520 530 540 550 560 pF1KE4 RIRQAETLEQVRSIMDEAPLTDVRDIKDT ::::::::::::::::::::::::::::: NP_079 RIRQAETLEQVRSIMDEAPLTDVRDIKDT 550 560 >>NP_001077054 (OMIM: 603616) rab GTPase-binding effecto (829 aa) initn: 782 init1: 359 opt: 593 Z-score: 338.0 bits: 73.0 E(85289): 4.4e-12 Smith-Waterman score: 686; 30.2% identity (62.0% similar) in 553 aa overlap (76-569:291-829) 50 60 70 80 90 100 pF1KE4 ELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALK :: .... .. .: : :. :: NP_001 EVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVL---TSEQLRQVEELK 270 280 290 300 310 110 120 130 140 150 160 pF1KE4 ---QERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKE :: ..::. ..:... . ... .. :. : :.. . :.. .: . . NP_001 KKDQEDDEQQRLNKRKDHKKADVEEEIK--IPVVCALTQEESSAQLSNE-EEHLDSTRGS 320 330 340 350 360 370 170 180 190 200 210 pF1KE4 IEELKAKLL---------RAEELIQEIQRRPRHAPSL--HGSTELLPLSRD-PSPPLEPL .. : : :: ...... :: . . :: :: . :. . . : NP_001 VHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNL 380 390 400 410 420 430 220 230 240 250 260 pF1KE4 EELSGDGGP--AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVS .: .: :: .:.. ..: : .::..:... .: ... .. ....:::::::::.: NP_001 DE--SDFGPLVGADSVSENFD-TASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLS 440 450 460 470 480 490 270 280 290 300 pF1KE4 TGTLVPEGIYLPPPGYQLVPDTQWEQLQTE--------GR----------QLQ------- . : :. :. : ::.:: .:.:. :: : :: ::: NP_001 SVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEA 500 510 520 530 540 550 310 320 330 340 pF1KE4 --KD---------------LESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLR .: ::.. ....::.. ...:.:: ..:...:. ..: :: ::. NP_001 ETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLE 560 570 580 590 600 610 350 360 370 380 390 400 pF1KE4 TLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGE :: .:::.. :: ::: :. ... . .:. ::...:..:.... . : :.: NP_001 ELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ-----QAE 620 630 640 650 660 410 420 430 440 450 460 pF1KE4 EESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQ . ::... :..:. :.. : .: :.:. ::. :.: .. : . .:: NP_001 DFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEET 670 680 690 700 710 720 470 480 490 500 510 520 pF1KE4 LRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQR :... :. . ::. ::..:.::.. :...: . .:. :.. :. :::.::..:::::: NP_001 LQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQR 730 740 750 760 770 780 530 540 550 560 pF1KE4 DFVRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDVRDIKDT :::.:::.:::.:::::::..::..:.:.... :::. .. .: NP_001 DFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET 790 800 810 820 >-- initn: 471 init1: 228 opt: 439 Z-score: 255.5 bits: 57.7 E(85289): 1.7e-07 Smith-Waterman score: 439; 47.5% identity (77.2% similar) in 162 aa overlap (21-181:52-213) 10 20 30 40 50 pF1KE4 MAAAAPVAADDDERRRRPGSALEDSRSQEGANGEAESGELSRLRAELAGA : :.. ....: .: . .:..::..: : NP_001 EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA 30 40 50 60 70 80 60 70 80 90 100 pF1KE4 LAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQI-TALKQERQ ::::..::.: :::.:: ::. :.:: .::::::::..:... .:: :. :.::: NP_001 QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT 90 100 110 120 130 140 110 120 130 140 150 160 pF1KE4 QQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAK : : : :::.. :.. ::.. ..::..:.::.::.:::: .:.:::::: :: : NP_001 QWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDK 150 160 170 180 190 200 170 180 190 200 210 220 pF1KE4 LLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCD : .::. :.:.. NP_001 LTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHE 210 220 230 240 250 260 >>XP_016880784 (OMIM: 603616) PREDICTED: rab GTPase-bind (552 aa) initn: 591 init1: 267 opt: 397 Z-score: 235.5 bits: 53.4 E(85289): 2.2e-06 Smith-Waterman score: 606; 31.2% identity (61.1% similar) in 475 aa overlap (175-569:86-552) 150 160 170 180 190 200 pF1KE4 AHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSL--HGSTELLPLSRD ..... :: . . :: :: . :. . XP_016 EHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYN 60 70 80 90 100 110 210 220 230 240 250 pF1KE4 -PSPPLEPLEELSGDGGP--AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPE . :.: .: :: .:.. ..: : .::..:... .: ... .. ....:: XP_016 YKAKSAGNLDE--SDFGPLVGADSVSENFD-TASLGSLQMPSGFMLTKDQERAIKAMTPE 120 130 140 150 160 170 260 270 280 290 300 pF1KE4 QEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTE--------GR----------Q :::::::.:. : :. :. : ::.:: .:.:. :: : :: : XP_016 QEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQ 180 190 200 210 220 230 310 320 330 pF1KE4 LQ---------KD---------------LESVSRERDELQEGLRRSNEDCAKQMQVLLAQ :: .: ::.. ....::.. ...:.:: ..:...:. . XP_016 LQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLR 240 250 260 270 280 290 340 350 360 370 380 390 pF1KE4 VQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAP .: :: ::. :: .:::.. :: ::: :. ... . .:. ::...:..:.... . XP_016 AQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKH----SL 300 310 320 330 340 400 410 420 430 440 450 pF1KE4 QGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEET . : : :.:. ::... :..:. :.. : .: :.:. ::. :.: .. : XP_016 HVSLQ-QAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQ 350 360 370 380 390 400 460 470 480 490 pF1KE4 VARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQ---------------------- . .:: :... :. . ::. ::..:.::.. :. XP_016 CLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKI 410 420 430 440 450 460 500 510 520 530 540 pF1KE4 -----------SKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQ .:: . .:. :.. :. :::.::..:::::::::.:::.:::.:::::: XP_016 SLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQ 470 480 490 500 510 520 550 560 pF1KE4 AETLEQVRSIMDEAPLTDVRDIKDT :..::..:.:.... :::. .. .: XP_016 ADSLERIRAILNDTKLTDINQLPET 530 540 550 >>XP_016880783 (OMIM: 603616) PREDICTED: rab GTPase-bind (574 aa) initn: 622 init1: 267 opt: 397 Z-score: 235.3 bits: 53.4 E(85289): 2.3e-06 Smith-Waterman score: 612; 29.2% identity (59.2% similar) in 552 aa overlap (101-569:39-574) 80 90 100 110 120 130 pF1KE4 AVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLS . :: ::... : . ::: ..: XP_016 CMKEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEKTPF--KIKITDR 10 20 30 40 50 60 140 150 160 170 180 pF1KE4 RAYP--LDSLEKQMEKAHEDSEKLRE-IVLPMEKEIEELKAKLLRAEELIQEIQRRPRHA .:: .. ....... . ..: ..:: . . ...... :: . . XP_016 SSYPEVTTNILEHLDSTRGSVHSLDAGLLLPSGDPFSK------SDNDMFKDGLRRAQST 70 80 90 100 110 120 190 200 210 220 230 240 pF1KE4 PSL--HGSTELLPLSRD-PSPPLEPLEELSGDGGP--AAEAFAHNCDDSASISSFSLGGG :: :: . :. . . :.: .: :: .:.. ..: : .::..:... .: XP_016 DSLGTSGSLQSKALGYNYKAKSAGNLDE--SDFGPLVGADSVSENFD-TASLGSLQMPSG 130 140 150 160 170 250 260 270 280 290 pF1KE4 VGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTE---- ... .. ....:::::::::.:. : :. :. : ::.:: .:.:. :: : XP_016 FMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 180 190 200 210 220 230 300 310 320 pF1KE4 ----GR----------QLQ---------KD---------------LESVSRERDELQEGL :: ::: .: ::.. ....::.. . XP_016 GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 240 250 260 270 280 290 330 340 350 360 370 380 pF1KE4 RRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRL ..:.:: ..:...:. ..: :: ::. :: .:::.. :: ::: :. ... . .:. :: XP_016 KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRL 300 310 320 330 340 350 390 400 410 420 430 440 pF1KE4 NEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAE ...:..:.... . : :.:. ::... :..:. :.. : .: : XP_016 QKDNDSLQGKHSLHVSLQ-----QAEDFILPDTTEALRELVLKYREDIINVRTAADHVEE 360 370 380 390 400 410 450 460 470 480 490 pF1KE4 RLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQ----- .:. ::. :.: .. : . .:: :... :. . ::. ::..:.::.. :. XP_016 KLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLES 420 430 440 450 460 470 500 510 520 pF1KE4 ----------------------------SKAQLPDLLSEQRAKVLRLQAELETSEQVQRD .:: . .:. :.. :. :::.::..::::::: XP_016 TLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRD 480 490 500 510 520 530 530 540 550 560 pF1KE4 FVRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDVRDIKDT ::.:::.:::.:::::::..::..:.:.... :::. .. .: XP_016 FVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET 540 550 560 570 >>NP_001278510 (OMIM: 603616) rab GTPase-binding effecto (819 aa) initn: 691 init1: 267 opt: 397 Z-score: 233.1 bits: 53.5 E(85289): 3e-06 Smith-Waterman score: 443; 46.7% identity (77.0% similar) in 165 aa overlap (18-181:6-170) 10 20 30 40 50 60 pF1KE4 MAAAAPVAADDDERRRRPGSALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAV :.: ... ....: .: . .:..::..: : ::::..::. NP_001 MAQPGPASQPDEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAI 10 20 30 40 70 80 90 100 110 pF1KE4 AEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQI-TALKQERQQQQQDCEEKE : :::.:: ::. :.:: .::::::::..:... .:: :. :.::: : : : : NP_001 ATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAE 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE4 RELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQE ::.. :.. ::.. ..::..:.::.::.:::: .:.:::::: :: :: .::. :.: NP_001 REIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 IQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSL .. NP_001 LEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQ 170 180 190 200 210 220 >-- initn: 691 init1: 267 opt: 405 Z-score: 237.4 bits: 54.3 E(85289): 1.7e-06 Smith-Waterman score: 615; 28.7% identity (58.5% similar) in 586 aa overlap (76-569:248-819) 50 60 70 80 90 100 pF1KE4 ELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALK :: .... .. .: : :. :: NP_001 EVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVL---TSEQLRQVEELK 220 230 240 250 260 270 110 120 130 140 150 160 pF1KE4 ---QERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKE :: ..::. ..:... . ... .. :. : :.. . :.. .: . . NP_001 KKDQEDDEQQRLNKRKDHKKADVEEEIK--IPVVCALTQEESSAQLSNE-EEHLDSTRGS 280 290 300 310 320 330 170 180 190 200 210 pF1KE4 IEELKAKLL---------RAEELIQEIQRRPRHAPSL--HGSTELLPLSRD-PSPPLEPL .. : : :: ...... :: . . :: :: . :. . . : NP_001 VHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNL 340 350 360 370 380 390 220 230 240 250 260 pF1KE4 EELSGDGGP--AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVS .: .: :: .:.. ..: : .::..:... .: ... .. ....:::::::::.: NP_001 DE--SDFGPLVGADSVSENFD-TASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLS 400 410 420 430 440 270 280 290 300 pF1KE4 TGTLVPEGIYLPPPGYQLVPDTQWEQLQTE--------GR----------QLQ------- . : :. :. : ::.:: .:.:. :: : :: ::: NP_001 SVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEA 450 460 470 480 490 500 310 320 330 340 pF1KE4 --KD---------------LESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLR .: ::.. ....::.. ...:.:: ..:...:. ..: :: ::. NP_001 ETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLE 510 520 530 540 550 560 350 360 370 380 390 400 pF1KE4 TLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGE :: .:::.. :: ::: :. ... . .:. ::...:..:.... . : :.: NP_001 ELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ-----QAE 570 580 590 600 610 620 410 420 430 440 450 460 pF1KE4 EESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQ . ::... :..:. :.. : .: :.:. ::. :.: .. : . .:: NP_001 DFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEET 630 640 650 660 670 680 470 480 490 pF1KE4 LRVQREETEVLEASLCSLRTEMERVQQEQ------------------------------- :... :. . ::. ::..:.::.. :. NP_001 LQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKE 690 700 710 720 730 740 500 510 520 530 540 550 pF1KE4 --SKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRS .:: . .:. :.. :. :::.::..:::::::::.:::.:::.:::::::..::..:. NP_001 TAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRA 750 760 770 780 790 800 560 pF1KE4 IMDEAPLTDVRDIKDT :.... :::. .. .: NP_001 ILNDTKLTDINQLPET 810 >>NP_004694 (OMIM: 603616) rab GTPase-binding effector p (862 aa) initn: 684 init1: 267 opt: 397 Z-score: 232.8 bits: 53.6 E(85289): 3.1e-06 Smith-Waterman score: 439; 47.5% identity (77.2% similar) in 162 aa overlap (21-181:52-213) 10 20 30 40 50 pF1KE4 MAAAAPVAADDDERRRRPGSALEDSRSQEGANGEAESGELSRLRAELAGA : :.. ....: .: . .:..::..: : NP_004 EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA 30 40 50 60 70 80 60 70 80 90 100 pF1KE4 LAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQI-TALKQERQ ::::..::.: :::.:: ::. :.:: .::::::::..:... .:: :. :.::: NP_004 QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT 90 100 110 120 130 140 110 120 130 140 150 160 pF1KE4 QQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAK : : : :::.. :.. ::.. ..::..:.::.::.:::: .:.:::::: :: : NP_004 QWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDK 150 160 170 180 190 200 170 180 190 200 210 220 pF1KE4 LLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCD : .::. :.:.. NP_004 LTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHE 210 220 230 240 250 260 >-- initn: 690 init1: 267 opt: 405 Z-score: 237.1 bits: 54.4 E(85289): 1.8e-06 Smith-Waterman score: 615; 28.7% identity (58.5% similar) in 586 aa overlap (76-569:291-862) 50 60 70 80 90 100 pF1KE4 ELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALK :: .... .. .: : :. :: NP_004 EVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVL---TSEQLRQVEELK 270 280 290 300 310 110 120 130 140 150 160 pF1KE4 ---QERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKE :: ..::. ..:... . ... .. :. : :.. . :.. .: . . NP_004 KKDQEDDEQQRLNKRKDHKKADVEEEIK--IPVVCALTQEESSAQLSNE-EEHLDSTRGS 320 330 340 350 360 370 170 180 190 200 210 pF1KE4 IEELKAKLL---------RAEELIQEIQRRPRHAPSL--HGSTELLPLSRD-PSPPLEPL .. : : :: ...... :: . . :: :: . :. . . : NP_004 VHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNL 380 390 400 410 420 430 220 230 240 250 260 pF1KE4 EELSGDGGP--AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVS .: .: :: .:.. ..: : .::..:... .: ... .. ....:::::::::.: NP_004 DE--SDFGPLVGADSVSENFD-TASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLS 440 450 460 470 480 490 270 280 290 300 pF1KE4 TGTLVPEGIYLPPPGYQLVPDTQWEQLQTE--------GR----------QLQ------- . : :. :. : ::.:: .:.:. :: : :: ::: NP_004 SVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEA 500 510 520 530 540 550 310 320 330 340 pF1KE4 --KD---------------LESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLR .: ::.. ....::.. ...:.:: ..:...:. ..: :: ::. NP_004 ETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLE 560 570 580 590 600 610 350 360 370 380 390 400 pF1KE4 TLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGE :: .:::.. :: ::: :. ... . .:. ::...:..:.... . : :.: NP_004 ELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ-----QAE 620 630 640 650 660 410 420 430 440 450 460 pF1KE4 EESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQ . ::... :..:. :.. : .: :.:. ::. :.: .. : . .:: NP_004 DFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEET 670 680 690 700 710 720 470 480 490 pF1KE4 LRVQREETEVLEASLCSLRTEMERVQQEQ------------------------------- :... :. . ::. ::..:.::.. :. NP_004 LQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKE 730 740 750 760 770 780 500 510 520 530 540 550 pF1KE4 --SKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRS .:: . .:. :.. :. :::.::..:::::::::.:::.:::.:::::::..::..:. NP_004 TAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRA 790 800 810 820 830 840 560 pF1KE4 IMDEAPLTDVRDIKDT :.... :::. .. .: NP_004 ILNDTKLTDINQLPET 850 860 >>XP_011522362 (OMIM: 603616) PREDICTED: rab GTPase-bind (884 aa) initn: 684 init1: 267 opt: 397 Z-score: 232.7 bits: 53.6 E(85289): 3.2e-06 Smith-Waterman score: 439; 47.5% identity (77.2% similar) in 162 aa overlap (21-181:52-213) 10 20 30 40 50 pF1KE4 MAAAAPVAADDDERRRRPGSALEDSRSQEGANGEAESGELSRLRAELAGA : :.. ....: .: . .:..::..: : XP_011 EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA 30 40 50 60 70 80 60 70 80 90 100 pF1KE4 LAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQI-TALKQERQ ::::..::.: :::.:: ::. :.:: .::::::::..:... .:: :. :.::: XP_011 QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT 90 100 110 120 130 140 110 120 130 140 150 160 pF1KE4 QQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAK : : : :::.. :.. ::.. ..::..:.::.::.:::: .:.:::::: :: : XP_011 QWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDK 150 160 170 180 190 200 170 180 190 200 210 220 pF1KE4 LLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCD : .::. :.:.. XP_011 LTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHE 210 220 230 240 250 260 >-- initn: 690 init1: 267 opt: 405 Z-score: 236.9 bits: 54.4 E(85289): 1.9e-06 Smith-Waterman score: 612; 29.2% identity (59.2% similar) in 552 aa overlap (101-569:349-884) 80 90 100 110 120 130 pF1KE4 AVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLS . :: ::... : . ::: ..: XP_011 KDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEKTPF--KIKITDR 320 330 340 350 360 370 140 150 160 170 180 pF1KE4 RAYP--LDSLEKQMEKAHEDSEKLRE-IVLPMEKEIEELKAKLLRAEELIQEIQRRPRHA .:: .. ....... . ..: ..:: . . ...... :: . . XP_011 SSYPEVTTNILEHLDSTRGSVHSLDAGLLLPSGDPFSK------SDNDMFKDGLRRAQST 380 390 400 410 420 430 190 200 210 220 230 240 pF1KE4 PSL--HGSTELLPLSRD-PSPPLEPLEELSGDGGP--AAEAFAHNCDDSASISSFSLGGG :: :: . :. . . :.: .: :: .:.. ..: : .::..:... .: XP_011 DSLGTSGSLQSKALGYNYKAKSAGNLDE--SDFGPLVGADSVSENFD-TASLGSLQMPSG 440 450 460 470 480 250 260 270 280 290 pF1KE4 VGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTE---- ... .. ....:::::::::.:. : :. :. : ::.:: .:.:. :: : XP_011 FMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 490 500 510 520 530 540 300 310 320 pF1KE4 ----GR----------QLQ---------KD---------------LESVSRERDELQEGL :: ::: .: ::.. ....::.. . XP_011 GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 550 560 570 580 590 600 330 340 350 360 370 380 pF1KE4 RRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRL ..:.:: ..:...:. ..: :: ::. :: .:::.. :: ::: :. ... . .:. :: XP_011 KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRL 610 620 630 640 650 660 390 400 410 420 430 440 pF1KE4 NEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAE ...:..:.... . : :.:. ::... :..:. :.. : .: : XP_011 QKDNDSLQGKHSLHVSLQ-----QAEDFILPDTTEALRELVLKYREDIINVRTAADHVEE 670 680 690 700 710 720 450 460 470 480 490 pF1KE4 RLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQ----- .:. ::. :.: .. : . .:: :... :. . ::. ::..:.::.. :. XP_011 KLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLES 730 740 750 760 770 780 500 510 520 pF1KE4 ----------------------------SKAQLPDLLSEQRAKVLRLQAELETSEQVQRD .:: . .:. :.. :. :::.::..::::::: XP_011 TLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRD 790 800 810 820 830 840 530 540 550 560 pF1KE4 FVRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDVRDIKDT ::.:::.:::.:::::::..::..:.:.... :::. .. .: XP_011 FVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET 850 860 870 880 >>NP_001278511 (OMIM: 603616) rab GTPase-binding effecto (190 aa) initn: 274 init1: 200 opt: 305 Z-score: 192.6 bits: 43.9 E(85289): 0.00054 Smith-Waterman score: 305; 41.7% identity (72.7% similar) in 139 aa overlap (21-158:52-190) 10 20 30 40 50 pF1KE4 MAAAAPVAADDDERRRRPGSALEDSRSQEGANGEAESGELSRLRAELAGA : :.. ....: .: . .:..::..: : NP_001 EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA 30 40 50 60 70 80 60 70 80 90 100 pF1KE4 LAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQI-TALKQERQ ::::..::.: :::.:: ::. :.:: .::::::::..:... .:: :. :.::: NP_001 QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT 90 100 110 120 130 140 110 120 130 140 150 160 pF1KE4 QQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAK : : : :::.. :.. ::.. ..::..:.: .. :. .: : NP_001 QWAQYRESAEREIADLRRRLSEGQEEENLENEMKKDPIQDTILHLVVSP 150 160 170 180 190 170 180 190 200 210 220 pF1KE4 LLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCD 569 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:49:11 2016 done: Sun Nov 6 01:49:13 2016 Total Scan time: 12.740 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]