FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1226, 300 aa 1>>>pF1KE1226 300 - 300 aa - 300 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4079+/-0.000284; mu= 15.6587+/- 0.018 mean_var=71.0956+/-14.146, 0's: 0 Z-trim(118.5): 30 B-trim: 0 in 0/59 Lambda= 0.152108 statistics sampled from 31575 (31606) to 31575 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.733), E-opt: 0.2 (0.371), width: 16 Scan time: 7.930 The best scores are: opt bits E(85289) NP_001093250 (OMIM: 611137) proteasome subunit bet ( 300) 2077 464.3 1.3e-130 NP_683720 (OMIM: 177046,256040) proteasome subunit ( 276) 797 183.4 4.4e-46 NP_004150 (OMIM: 177046,256040) proteasome subunit ( 272) 778 179.2 7.8e-45 NP_002788 (OMIM: 600306) proteasome subunit beta t ( 263) 771 177.7 2.2e-44 NP_001124197 (OMIM: 600306) proteasome subunit bet ( 160) 577 135.0 9.6e-32 XP_005267928 (OMIM: 600306) PREDICTED: proteasome ( 169) 426 101.9 9.4e-22 NP_001138404 (OMIM: 600306) proteasome subunit bet ( 203) 426 101.9 1.1e-21 NP_002789 (OMIM: 600307) proteasome subunit beta t ( 239) 354 86.1 7.2e-17 NP_002790 (OMIM: 604030) proteasome subunit beta t ( 277) 314 77.4 3.5e-14 NP_002791 (OMIM: 177045) proteasome subunit beta t ( 219) 295 73.2 5.3e-13 NP_001257410 (OMIM: 600307) proteasome subunit bet ( 213) 290 72.1 1.1e-12 NP_002792 (OMIM: 176847) proteasome subunit beta t ( 273) 277 69.3 9.7e-12 NP_002784 (OMIM: 602017) proteasome subunit beta t ( 241) 157 42.9 0.00074 NP_002786 (OMIM: 602176) proteasome subunit beta t ( 205) 155 42.4 0.00088 >>NP_001093250 (OMIM: 611137) proteasome subunit beta ty (300 aa) initn: 2077 init1: 2077 opt: 2077 Z-score: 2465.9 bits: 464.3 E(85289): 1.3e-130 Smith-Waterman score: 2077; 100.0% identity (100.0% similar) in 300 aa overlap (1-300:1-300) 10 20 30 40 50 60 pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTLAFRFRHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTLAFRFRHG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 QLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGDIFSVGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGDIFSVGSG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSRSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSRSD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 ACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTETV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTETV 250 260 270 280 290 300 >>NP_683720 (OMIM: 177046,256040) proteasome subunit bet (276 aa) initn: 857 init1: 769 opt: 797 Z-score: 948.4 bits: 183.4 E(85289): 4.4e-46 Smith-Waterman score: 817; 49.4% identity (69.4% similar) in 265 aa overlap (1-240:1-263) 10 20 30 40 pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGG-----------------WAVPRGCDPQTFLQI-- ::: ::: .: : : :: ::. :.::: .: :.: NP_683 MALLDVC--GAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLG 10 20 30 40 50 50 60 70 80 90 pF1KE1 -HGPR-----LAHGTTTLAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTS : : .:::::::::.:.::::::.:.:.: :::.. ::: .. .:::: : NP_683 GDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMS 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE1 GTSADCATWYRVLQRELRLRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDR : .::: : :.: .: :: ::.:. ::..:.:::: :: ::::. : ... .::::. NP_683 GCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDK 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE1 SGPELFYVYSDGTRLQGDIFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHR .:: :.:: ::::.:..::.:::. :::::.: ::: ..: .::: :.: :.:.:::: NP_683 KGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHR 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE1 DAYSGGSVDLFHVRESGWEHVSRSDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAE :.:::: :...:..:.:: .: .: NP_683 DSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ 240 250 260 270 >>NP_004150 (OMIM: 177046,256040) proteasome subunit bet (272 aa) initn: 766 init1: 766 opt: 778 Z-score: 925.9 bits: 179.2 E(85289): 7.8e-45 Smith-Waterman score: 779; 50.2% identity (72.0% similar) in 239 aa overlap (13-240:30-259) 10 20 30 40 pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGC---DPQTFLQ :: :.: : :: .: :.: NP_004 MLIGTPTPRDTTPSSWLTSSLLVEAAPLDDTTLPTP---------VSSGCPGLEPTEFFQ 10 20 30 40 50 50 60 70 80 90 pF1KE1 IHGP--------RLAHGTTTLAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLG : ..:::::::::.:.::::::.:.:.: :::.. ::: .. .::: NP_004 SLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLG 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE1 TTSGTSADCATWYRVLQRELRLRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCG : :: .::: : :.: .: :: ::.:. ::..:.:::: :: ::::. : ... .:: NP_004 TMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICG 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE1 WDRSGPELFYVYSDGTRLQGDIFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHA ::..:: :.:: ::::.:..::.:::. :::::.: ::: ..: .::: :.: :.:.: NP_004 WDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYA 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE1 THRDAYSGGSVDLFHVRESGWEHVSRSDACVLYVELQKLLEPEPEEDASHAHPEPATAHR ::::.:::: :...:..:.:: .: .: NP_004 THRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ 240 250 260 270 >>NP_002788 (OMIM: 600306) proteasome subunit beta type- (263 aa) initn: 790 init1: 763 opt: 771 Z-score: 917.8 bits: 177.7 E(85289): 2.2e-44 Smith-Waterman score: 786; 52.7% identity (77.9% similar) in 222 aa overlap (24-245:43-255) 10 20 30 40 50 pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTL : ::.::. .: : .. :::::: NP_002 VNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPE--EP-------GIEMLHGTTTL 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 AFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELR ::.::::::.:::.:.. :.:.: . ::: .. .:::: .: .:::. : :.: :. : NP_002 AFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 LRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGD . :::. . :::.:.:::. :. ::.:. : ..: .::::. :: :.:: :.:.:..: NP_002 IYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 IFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGW ::::::: :::::.:::: ::. ...:: ::: :. .::.:::::::.:.:.::::.:: NP_002 TFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGW 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE1 EHVSRSDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRM .:: ... :. NP_002 IRVSSDNVADLHEKYSGSTP 250 260 >>NP_001124197 (OMIM: 600306) proteasome subunit beta ty (160 aa) initn: 567 init1: 567 opt: 577 Z-score: 690.9 bits: 135.0 E(85289): 9.6e-32 Smith-Waterman score: 577; 54.3% identity (80.8% similar) in 151 aa overlap (95-245:2-152) 70 80 90 100 110 120 pF1KE1 ADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREGQLPS .: .:::. : :.: :. :. :::. . : NP_001 MAGGAADCSFWERLLARQCRIYELRNKERIS 10 20 30 130 140 150 160 170 180 pF1KE1 VASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGDIFSVGSGSPYA ::.:.:::. :. ::.:. : ..: .::::. :: :.:: :.:.:..: ::::::: :: NP_001 VAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYA 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE1 YGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSRSDACVL :::.:::: ::. ...:: ::: :. .::.:::::::.:.:.::::.:: .:: ... : NP_001 YGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADL 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE1 YVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTETV . NP_001 HEKYSGSTP 160 >>XP_005267928 (OMIM: 600306) PREDICTED: proteasome subu (169 aa) initn: 453 init1: 426 opt: 426 Z-score: 511.5 bits: 101.9 E(85289): 9.4e-22 Smith-Waterman score: 441; 48.9% identity (74.1% similar) in 135 aa overlap (24-158:43-168) 10 20 30 40 50 pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTL : ::.::. .: : .. :::::: XP_005 VNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPE--EP-------GIEMLHGTTTL 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 AFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELR ::.::::::.:::.:.. :.:.: . ::: .. .:::: .: .:::. : :.: :. : XP_005 AFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 LRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGD . :::. . :::.:.:::. :. ::.:. : ..: .::::. :: XP_005 IYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPG 130 140 150 160 180 190 200 210 220 230 pF1KE1 IFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGW >>NP_001138404 (OMIM: 600306) proteasome subunit beta ty (203 aa) initn: 453 init1: 426 opt: 426 Z-score: 510.3 bits: 101.9 E(85289): 1.1e-21 Smith-Waterman score: 441; 48.9% identity (74.1% similar) in 135 aa overlap (24-158:43-168) 10 20 30 40 50 pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTL : ::.::. .: : .. :::::: NP_001 VNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPE--EP-------GIEMLHGTTTL 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 AFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELR ::.::::::.:::.:.. :.:.: . ::: .. .:::: .: .:::. : :.: :. : NP_001 AFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 LRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGD . :::. . :::.:.:::. :. ::.:. : ..: .::::. :: NP_001 IYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPVSEVLCLKPKSFGMY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 IFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGW NP_001 LFCGCAERIGNMARPLLRGQ 190 200 >>NP_002789 (OMIM: 600307) proteasome subunit beta type- (239 aa) initn: 332 init1: 305 opt: 354 Z-score: 423.9 bits: 86.1 E(85289): 7.2e-17 Smith-Waterman score: 354; 32.7% identity (60.7% similar) in 214 aa overlap (23-234:9-219) 10 20 30 40 50 pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPR-LAHGTTTLAFRFRH :..: : : :..: : .. ::: .: .: NP_002 MAATLLAARGAGPAPAWG--PEAFTPDWESREVSTGTTIMAVQFDG 10 20 30 40 60 70 80 90 100 110 pF1KE1 GVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELRE ::. .::.:.. :::.: .. :. :.:.... ::..:: . .. .: .. .. NP_002 GVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIEL 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 GQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWD-RSGPELFYVYSDGTRLQGDIFSVG .. : : .::.:.. : .:: :: .. . ::: . : ... : : .. .. : NP_002 NEPPLVHTAASLFKEMCYRYRE-DLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGG 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 SGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSR ::: : :: .: :: :. .: .. :.: : .::. ::: . : . ::: : NP_002 SGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVL 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 SDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTE NP_002 LGDQIPKFAVATLPPA 230 >>NP_002790 (OMIM: 604030) proteasome subunit beta type- (277 aa) initn: 312 init1: 166 opt: 314 Z-score: 375.5 bits: 77.4 E(85289): 3.5e-14 Smith-Waterman score: 314; 29.6% identity (59.3% similar) in 216 aa overlap (18-225:5-218) 10 20 30 40 50 pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQI----HGPRLAH----GTTT : . : .::.. .: .. :. .: .: . ::: NP_002 MAAVSVYAPPVGGFSFD-NCRRNAVLEADFAKRGYKLPKVRKTGTTI 10 20 30 40 60 70 80 90 100 110 pF1KE1 LAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQREL . .. :.. .::::.. : :: :. . .. .::.:: .... .: NP_002 AGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNL 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 RLRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQG .:. : :.:: :..: ..:. :. .:.: . .: .: : : .::.:. .: :. . NP_002 ELHSLSTGRLPRVVTANRMLKQMLFRYQGY-IGAALVLGGVDVTGPHLYSIYPHGSTDKL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 DIFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESG ..:::: :..:.. .: :: .:: :. :.: . : ::...:: NP_002 PYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNK 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 WEHVSRSDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSR NP_002 LDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS 230 240 250 260 270 >>NP_002791 (OMIM: 177045) proteasome subunit beta type- (219 aa) initn: 312 init1: 154 opt: 295 Z-score: 354.5 bits: 73.2 E(85289): 5.3e-13 Smith-Waterman score: 297; 30.7% identity (57.2% similar) in 215 aa overlap (23-235:3-205) 10 20 30 40 50 60 pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTLAFRFRHG ::: .: : :.. ..: ::: .: .: : NP_002 MLRAG---APTGDLPRAG-EVHT-----GTTIMAVEFDGG 10 20 30 70 80 90 100 110 120 pF1KE1 VIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREG :. ..:.: : : :. . :. :.:... . ::..:: . . .:.:. .. NP_002 VVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELE 40 50 60 70 80 90 130 140 150 160 170 pF1KE1 QLPSVASAAKLLSAMMSQYRGLDLCVATALCGWD-RSGPELFYVYSDGTRLQGDIFSVG- . : : .::... . .:: :: . . ::: : : ... . : : . :..: NP_002 EPPLVLAAANVVRNISYKYRE-DLSAHLMVAGWDQREGGQVYGTL--GGMLTRQPFAIGG 100 110 120 130 140 180 190 200 210 220 230 pF1KE1 SGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSR ::: . :: .: .:. :: .: .. :.: : ::. ::: . : . .: .: NP_002 SGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVI 150 160 170 180 190 200 240 250 260 270 280 290 pF1KE1 SDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTE NP_002 LGNELPKFYDE 210 300 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 11:06:40 2016 done: Sun Nov 6 11:06:41 2016 Total Scan time: 7.930 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]