FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3993, 418 aa 1>>>pF1KB3993 418 - 418 aa - 418 aa Library: /omim/omim.rfq.tfa 63617473 residues in 89429 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6736+/-0.000323; mu= 21.2526+/- 0.020 mean_var=72.4482+/-15.032, 0's: 0 Z-trim(116.0): 16 B-trim: 0 in 0/51 Lambda= 0.150682 statistics sampled from 27458 (27473) to 27458 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.307), width: 16 Scan time: 4.360 The best scores are: opt bits E(89429) NP_003264 (OMIM: 603414) delta(14)-sterol reductas ( 418) 2854 629.6 4.6e-180 NP_001264162 (OMIM: 603414) delta(14)-sterol reduc ( 391) 2002 444.4 2.5e-124 NP_919424 (OMIM: 169400,215140,600024,613471) lami ( 615) 1676 373.7 7.3e-103 XP_011542487 (OMIM: 169400,215140,600024,613471) P ( 615) 1676 373.7 7.3e-103 NP_002287 (OMIM: 169400,215140,600024,613471) lami ( 615) 1676 373.7 7.3e-103 XP_005273182 (OMIM: 169400,215140,600024,613471) P ( 573) 965 219.1 2.4e-56 NP_001351 (OMIM: 270400,602858) 7-dehydrocholester ( 475) 546 127.9 5.4e-29 NP_001157289 (OMIM: 270400,602858) 7-dehydrocholes ( 475) 546 127.9 5.4e-29 XP_011543079 (OMIM: 270400,602858) PREDICTED: 7-de ( 456) 417 99.9 1.5e-20 >>NP_003264 (OMIM: 603414) delta(14)-sterol reductase is (418 aa) initn: 2854 init1: 2854 opt: 2854 Z-score: 3354.1 bits: 629.6 E(89429): 4.6e-180 Smith-Waterman score: 2854; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 RALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 PRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 EEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 YYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALA 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 WSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 WSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY 370 380 390 400 410 >>NP_001264162 (OMIM: 603414) delta(14)-sterol reductase (391 aa) initn: 2002 init1: 2002 opt: 2002 Z-score: 2353.5 bits: 444.4 E(89429): 2.5e-124 Smith-Waterman score: 2608; 93.5% identity (93.5% similar) in 418 aa overlap (1-418:1-391) 10 20 30 40 50 60 pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 RALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 PRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 EEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLIN--- 250 260 270 280 290 310 320 330 340 350 360 pF1KB3 YYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALA :::::::::::::::::::::::::::::::::::: NP_001 ------------------------GLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALA 300 310 320 330 370 380 390 400 410 pF1KB3 WSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY 340 350 360 370 380 390 >>NP_919424 (OMIM: 169400,215140,600024,613471) lamin-B (615 aa) initn: 1419 init1: 1081 opt: 1676 Z-score: 1968.0 bits: 373.7 E(89429): 7.3e-103 Smith-Waterman score: 1676; 59.0% identity (81.0% similar) in 410 aa overlap (11-418:207-615) 10 20 30 40 pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSG ::::: :. ... ::. .: ::: .. NP_919 LKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQK 180 190 200 210 220 230 50 60 70 80 90 100 pF1KB3 PARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPI ::. : ::.: :: :.. ..: :. .:. .:::: ::.:: : : ::.: . NP_919 DPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRL 240 250 260 270 280 290 110 120 130 140 150 160 pF1KB3 NGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSAL ::: :..::. ..: .. :. . . .: .:..::. ..:..:::.. :: . : NP_919 NGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDL 300 310 320 330 340 350 170 180 190 200 210 pF1KB3 APGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAEL--RGS .:. .::: .::::.:::::::: ::.::::::::::::::.:::..:. : .. :. NP_919 SPA-SSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAV 360 370 380 390 400 410 220 230 240 250 260 270 pF1KB3 PSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFL ::::: :::.:::::: ::::.:::.:::::: ::::::::::::..:::: ::.:: .: NP_919 PSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYL 420 430 440 450 460 470 280 290 300 310 320 330 pF1KB3 LHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLL . ::. .. ::::.: ... :: ::::::::::.::::::::..: :.:: :.::..:: NP_919 VSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLL 480 490 500 510 520 530 340 350 360 370 380 390 pF1KB3 VSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKY ::::::.::::::::::::::::::::: .:.:::::..::: :::::::::: .: .:: NP_919 VSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKY 540 550 560 570 580 590 400 410 pF1KB3 GLAWQEYCRRVPYRIMPYIY :.::..::.::::::.:::: NP_919 GVAWEKYCQRVPYRIFPYIY 600 610 >>XP_011542487 (OMIM: 169400,215140,600024,613471) PREDI (615 aa) initn: 1419 init1: 1081 opt: 1676 Z-score: 1968.0 bits: 373.7 E(89429): 7.3e-103 Smith-Waterman score: 1676; 59.0% identity (81.0% similar) in 410 aa overlap (11-418:207-615) 10 20 30 40 pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSG ::::: :. ... ::. .: ::: .. XP_011 LKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQK 180 190 200 210 220 230 50 60 70 80 90 100 pF1KB3 PARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPI ::. : ::.: :: :.. ..: :. .:. .:::: ::.:: : : ::.: . XP_011 DPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRL 240 250 260 270 280 290 110 120 130 140 150 160 pF1KB3 NGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSAL ::: :..::. ..: .. :. . . .: .:..::. ..:..:::.. :: . : XP_011 NGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDL 300 310 320 330 340 350 170 180 190 200 210 pF1KB3 APGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAEL--RGS .:. .::: .::::.:::::::: ::.::::::::::::::.:::..:. : .. :. XP_011 SPA-SSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAV 360 370 380 390 400 410 220 230 240 250 260 270 pF1KB3 PSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFL ::::: :::.:::::: ::::.:::.:::::: ::::::::::::..:::: ::.:: .: XP_011 PSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYL 420 430 440 450 460 470 280 290 300 310 320 330 pF1KB3 LHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLL . ::. .. ::::.: ... :: ::::::::::.::::::::..: :.:: :.::..:: XP_011 VSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLL 480 490 500 510 520 530 340 350 360 370 380 390 pF1KB3 VSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKY ::::::.::::::::::::::::::::: .:.:::::..::: :::::::::: .: .:: XP_011 VSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKY 540 550 560 570 580 590 400 410 pF1KB3 GLAWQEYCRRVPYRIMPYIY :.::..::.::::::.:::: XP_011 GVAWEKYCQRVPYRIFPYIY 600 610 >>NP_002287 (OMIM: 169400,215140,600024,613471) lamin-B (615 aa) initn: 1419 init1: 1081 opt: 1676 Z-score: 1968.0 bits: 373.7 E(89429): 7.3e-103 Smith-Waterman score: 1676; 59.0% identity (81.0% similar) in 410 aa overlap (11-418:207-615) 10 20 30 40 pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSG ::::: :. ... ::. .: ::: .. NP_002 LKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQK 180 190 200 210 220 230 50 60 70 80 90 100 pF1KB3 PARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPI ::. : ::.: :: :.. ..: :. .:. .:::: ::.:: : : ::.: . NP_002 DPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRL 240 250 260 270 280 290 110 120 130 140 150 160 pF1KB3 NGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSAL ::: :..::. ..: .. :. . . .: .:..::. ..:..:::.. :: . : NP_002 NGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDL 300 310 320 330 340 350 170 180 190 200 210 pF1KB3 APGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAEL--RGS .:. .::: .::::.:::::::: ::.::::::::::::::.:::..:. : .. :. NP_002 SPA-SSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAV 360 370 380 390 400 410 220 230 240 250 260 270 pF1KB3 PSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFL ::::: :::.:::::: ::::.:::.:::::: ::::::::::::..:::: ::.:: .: NP_002 PSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYL 420 430 440 450 460 470 280 290 300 310 320 330 pF1KB3 LHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLL . ::. .. ::::.: ... :: ::::::::::.::::::::..: :.:: :.::..:: NP_002 VSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLL 480 490 500 510 520 530 340 350 360 370 380 390 pF1KB3 VSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKY ::::::.::::::::::::::::::::: .:.:::::..::: :::::::::: .: .:: NP_002 VSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKY 540 550 560 570 580 590 400 410 pF1KB3 GLAWQEYCRRVPYRIMPYIY :.::..::.::::::.:::: NP_002 GVAWEKYCQRVPYRIFPYIY 600 610 >>XP_005273182 (OMIM: 169400,215140,600024,613471) PREDI (573 aa) initn: 1294 init1: 956 opt: 965 Z-score: 1133.1 bits: 219.1 E(89429): 2.4e-56 Smith-Waterman score: 1434; 52.9% identity (72.8% similar) in 408 aa overlap (11-418:207-573) 10 20 30 40 pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSG ::::: :. ... ::. .: ::: .. XP_005 LKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQK 180 190 200 210 220 230 50 60 70 80 90 100 pF1KB3 PARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPI ::. : ::.: :: :.. ..: :. .:. .:::: ::.:: : : ::.: . XP_005 DPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRL 240 250 260 270 280 290 110 120 130 140 150 160 pF1KB3 NGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSAL ::: :..::. ..: .. :. . . .: .:..::. ..:..:::.. :: . : XP_005 NGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDL 300 310 320 330 340 350 170 180 190 200 210 220 pF1KB3 APGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPS .:. .::: .::::.:::::::: ::.::::::::::::: XP_005 SPA-SSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGW------------------- 360 370 380 390 230 240 250 260 270 280 pF1KB3 LAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLH ::.:::::: ::::::::::::..:::: ::.:: .:. XP_005 ---------------------EALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVS 400 410 420 430 290 300 310 320 330 340 pF1KB3 HPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVS ::. .. ::::.: ... :: ::::::::::.::::::::..: :.:: :.::..:::: XP_005 HPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVS 440 450 460 470 480 490 350 360 370 380 390 400 pF1KB3 GWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGL ::::.::::::::::::::::::::: .:.:::::..::: :::::::::: .: .:::. XP_005 GWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGV 500 510 520 530 540 550 410 pF1KB3 AWQEYCRRVPYRIMPYIY ::..::.::::::.:::: XP_005 AWEKYCQRVPYRIFPYIY 560 570 >>NP_001351 (OMIM: 270400,602858) 7-dehydrocholesterol r (475 aa) initn: 864 init1: 427 opt: 546 Z-score: 641.9 bits: 127.9 E(89429): 5.4e-29 Smith-Waterman score: 901; 37.6% identity (63.8% similar) in 431 aa overlap (22-418:46-475) 10 20 30 40 50 pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASL :::. : ......: . : :: ... NP_001 DGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDI 20 30 40 50 60 70 60 70 80 90 pF1KB3 -PG---LEVLW--SP----RALLLWLAWLGLQAALY---------LLPAR--KVAEGQEL : : .: .: .: :. :. .:. :: .::. . :: NP_001 VTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVT 80 90 100 110 120 130 100 110 120 130 140 pF1KB3 KDKSRLRYPINGFQALVLTALL--VGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFL .: :::.:: .:: :: .. . . . . . .:: . :.. .. : : NP_001 PAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFA 140 150 160 170 180 190 150 160 170 180 190 200 pF1KB3 YMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRIC-FFDFKYFCELRPGLIGWVLINLA ..:. :.:: .:: .:....: :.:::: .:::: : . :::...:.::::. NP_001 MVKGYFFPTSA-RDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLS 200 210 220 230 240 250 210 220 230 240 250 260 pF1KB3 LLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWV . :. ::.. . :: ::: .: .:: : .:.: : :.:: :: ::..:..:: .:. NP_001 FAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWL 260 270 280 290 300 310 270 280 290 300 310 320 pF1KB3 PFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLE :. :.::. .:..:: :. : : . :.. .:::::: :: ::. ::.. . . : . NP_001 PYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRK 320 330 340 350 360 370 330 340 350 360 370 pF1KB3 ------TISTATGR----KLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLL . ..: :. ::::::.::..:: ::.:::. .::. : :: .:::::::.. NP_001 PKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYII 380 390 400 410 420 430 380 390 400 410 pF1KB3 YFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY :.. ::.:: :::..: .::: :..: ::::..: :. NP_001 YMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 440 450 460 470 >>NP_001157289 (OMIM: 270400,602858) 7-dehydrocholestero (475 aa) initn: 864 init1: 427 opt: 546 Z-score: 641.9 bits: 127.9 E(89429): 5.4e-29 Smith-Waterman score: 901; 37.6% identity (63.8% similar) in 431 aa overlap (22-418:46-475) 10 20 30 40 50 pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASL :::. : ......: . : :: ... NP_001 DGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDI 20 30 40 50 60 70 60 70 80 90 pF1KB3 -PG---LEVLW--SP----RALLLWLAWLGLQAALY---------LLPAR--KVAEGQEL : : .: .: .: :. :. .:. :: .::. . :: NP_001 VTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVT 80 90 100 110 120 130 100 110 120 130 140 pF1KB3 KDKSRLRYPINGFQALVLTALL--VGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFL .: :::.:: .:: :: .. . . . . . .:: . :.. .. : : NP_001 PAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFA 140 150 160 170 180 190 150 160 170 180 190 200 pF1KB3 YMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRIC-FFDFKYFCELRPGLIGWVLINLA ..:. :.:: .:: .:....: :.:::: .:::: : . :::...:.::::. NP_001 MVKGYFFPTSA-RDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLS 200 210 220 230 240 250 210 220 230 240 250 260 pF1KB3 LLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWV . :. ::.. . :: ::: .: .:: : .:.: : :.:: :: ::..:..:: .:. NP_001 FAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWL 260 270 280 290 300 310 270 280 290 300 310 320 pF1KB3 PFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLE :. :.::. .:..:: :. : : . :.. .:::::: :: ::. ::.. . . : . NP_001 PYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRK 320 330 340 350 360 370 330 340 350 360 370 pF1KB3 ------TISTATGR----KLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLL . ..: :. ::::::.::..:: ::.:::. .::. : :: .:::::::.. NP_001 PKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYII 380 390 400 410 420 430 380 390 400 410 pF1KB3 YFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY :.. ::.:: :::..: .::: :..: ::::..: :. NP_001 YMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 440 450 460 470 >>XP_011543079 (OMIM: 270400,602858) PREDICTED: 7-dehydr (456 aa) initn: 429 init1: 299 opt: 417 Z-score: 490.5 bits: 99.9 E(89429): 1.5e-20 Smith-Waterman score: 449; 33.6% identity (59.9% similar) in 277 aa overlap (22-274:46-321) 10 20 30 40 50 pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASL :::. : ......: . : :: ... XP_011 DGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDI 20 30 40 50 60 70 60 70 80 90 pF1KB3 -PG---LEVLW--SP----RALLLWLAWLGLQAALY---------LLPAR--KVAEGQEL : : .: .: .: :. :. .:. :: .::. . :: XP_011 VTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVT 80 90 100 110 120 130 100 110 120 130 140 pF1KB3 KDKSRLRYPINGFQALVLTALL--VGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFL .: :::.:: .:: :: .. . . . . . .:: . :.. .. : : XP_011 PAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFA 140 150 160 170 180 190 150 160 170 180 190 200 pF1KB3 YMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRIC-FFDFKYFCELRPGLIGWVLINLA ..:. :.:: .:: .:....: :.:::: .:::: : . :::...:.::::. XP_011 MVKGYFFPTSA-RDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLS 200 210 220 230 240 250 210 220 230 240 250 260 pF1KB3 LLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWV . :. ::.. . :: ::: .: .:: : .:.: : :.:: :: ::..:..:: .:. XP_011 FAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWL 260 270 280 290 300 310 270 280 290 300 310 320 pF1KB3 PFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLE :. :.:: XP_011 PYLYTLQKRTRRQGVCQRQSWGLTPGRWAPEPTLLSSPWAKHRLTPSPSPPRVCTWCTTP 320 330 340 350 360 370 418 residues in 1 query sequences 63617473 residues in 89429 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 16 14:50:25 2017 done: Thu Nov 16 14:50:26 2017 Total Scan time: 4.360 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]