Result of FASTA (omim) for
pFN21AE3956
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3956, 511 aa
1>>>pF1KE3956 511 - 511 aa - 511 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7827+/-0.00039; mu= 15.8326+/- 0.024
mean_var=72.8556+/-14.996, 0's: 0 Z-trim(112.3): 28 B-trim: 635 in 1/52
Lambda= 0.150260
statistics sampled from 21147 (21171) to 21147 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.62), E-opt: 0.2 (0.248), width: 16
Scan time: 8.750
The best scores are: opt bits E(85289)
NP_001070710 (OMIM: 612294) DEP domain-containing ( 511) 3337 733.0 5e-211
NP_631899 (OMIM: 612294) DEP domain-containing pro ( 502) 3182 699.4 6.4e-201
NP_060249 (OMIM: 612002) DEP domain-containing pro ( 527) 464 110.2 1.6e-23
NP_060839 (OMIM: 616073) DEP domain-containing pro ( 529) 402 96.7 1.7e-19
XP_011541811 (OMIM: 616073) PREDICTED: DEP domain- ( 514) 304 75.5 4.2e-13
NP_001138680 (OMIM: 616073) DEP domain-containing ( 467) 292 72.9 2.4e-12
NP_001107592 (OMIM: 612002) DEP domain-containing ( 811) 251 64.1 1.8e-09
XP_011541812 (OMIM: 616073) PREDICTED: DEP domain- ( 347) 235 60.5 9.6e-09
XP_016865118 (OMIM: 616073) PREDICTED: DEP domain- ( 330) 225 58.3 4.1e-08
>>NP_001070710 (OMIM: 612294) DEP domain-containing prot (511 aa)
initn: 3337 init1: 3337 opt: 3337 Z-score: 3909.6 bits: 733.0 E(85289): 5e-211
Smith-Waterman score: 3337; 99.8% identity (99.8% similar) in 511 aa overlap (1-511:1-511)
10 20 30 40 50 60
pF1KE3 MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 RHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KPTFEDSSCSLYRFTTIPNQDSQLGKENKLYSPARYADALFKSSDIRSASLEDLWENLSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPTFEDSSCSLYRFTTIPNQDSQLGKENKLYSPARYADALFKSSDIRSASLEDLWENLSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 KPANSPHVNISATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQEAVPKIPQPKRQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPANSPHVNISATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQEAVPKIPQPKRQS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 TMVNSSNYLDRGILKAYSDSQEDEWLSAAIDCLEYLPDQMVVEISRSFPEQPDRTDLVKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMVNSSNYLDRGILKAYSDSQEDEWLSAAIDCLEYLPDQMVVEISRSFPEQPDRTDLVKE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 LLFDAIGRYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEATQLLLKLLDFQNREEFRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLFDAIGRYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEATQLLLKLLDFQNREEFRR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 LLYFMAVAANPSEFKLQKESDNRMVVKRIFSKAIVDNKNLSKGKTDLLVLFLMDHQKDVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLYFMAVAANPSEFKLQKESDNRMVVKRIFSKAIVDNKNLSKGKTDLLVLFLMDHQKDVF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 KIPGTLHKIVSVKLMAIQNGRDPNRDAGYIYCQRIDQRDYSNNIEKTTKDELLNLLKTLD
::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
NP_001 KIPGTLHKIVSVKLMAIQNGRDPNRDAGYIYCQRIDQRDYSNNTEKTTKDELLNLLKTLD
430 440 450 460 470 480
490 500 510
pF1KE3 EDSKLSAKEKKKLLGQFYKCHPDIFIEHFGD
:::::::::::::::::::::::::::::::
NP_001 EDSKLSAKEKKKLLGQFYKCHPDIFIEHFGD
490 500 510
>>NP_631899 (OMIM: 612294) DEP domain-containing protein (502 aa)
initn: 3182 init1: 3182 opt: 3182 Z-score: 3728.1 bits: 699.4 E(85289): 6.4e-201
Smith-Waterman score: 3182; 99.8% identity (99.8% similar) in 487 aa overlap (25-511:16-502)
10 20 30 40 50 60
pF1KE3 MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLK
::::::::::::::::::::::::::::::::::::
NP_631 MRGLCEFYWQEFGIKGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLK
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 RHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_631 RHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE3 KPTFEDSSCSLYRFTTIPNQDSQLGKENKLYSPARYADALFKSSDIRSASLEDLWENLSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_631 KPTFEDSSCSLYRFTTIPNQDSQLGKENKLYSPARYADALFKSSDIRSASLEDLWENLSL
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE3 KPANSPHVNISATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQEAVPKIPQPKRQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_631 KPANSPHVNISATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQEAVPKIPQPKRQS
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE3 TMVNSSNYLDRGILKAYSDSQEDEWLSAAIDCLEYLPDQMVVEISRSFPEQPDRTDLVKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_631 TMVNSSNYLDRGILKAYSDSQEDEWLSAAIDCLEYLPDQMVVEISRSFPEQPDRTDLVKE
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE3 LLFDAIGRYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEATQLLLKLLDFQNREEFRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_631 LLFDAIGRYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEATQLLLKLLDFQNREEFRR
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE3 LLYFMAVAANPSEFKLQKESDNRMVVKRIFSKAIVDNKNLSKGKTDLLVLFLMDHQKDVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_631 LLYFMAVAANPSEFKLQKESDNRMVVKRIFSKAIVDNKNLSKGKTDLLVLFLMDHQKDVF
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE3 KIPGTLHKIVSVKLMAIQNGRDPNRDAGYIYCQRIDQRDYSNNIEKTTKDELLNLLKTLD
::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
NP_631 KIPGTLHKIVSVKLMAIQNGRDPNRDAGYIYCQRIDQRDYSNNTEKTTKDELLNLLKTLD
420 430 440 450 460 470
490 500 510
pF1KE3 EDSKLSAKEKKKLLGQFYKCHPDIFIEHFGD
:::::::::::::::::::::::::::::::
NP_631 EDSKLSAKEKKKLLGQFYKCHPDIFIEHFGD
480 490 500
>>NP_060249 (OMIM: 612002) DEP domain-containing protein (527 aa)
initn: 366 init1: 140 opt: 464 Z-score: 543.5 bits: 110.2 E(85289): 1.6e-23
Smith-Waterman score: 479; 23.8% identity (58.5% similar) in 520 aa overlap (23-509:7-495)
10 20 30 40 50 60
pF1KE3 MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLK
::: :. :: .:. . ..... . ..:.:...:
NP_060 MESQGVPPG------PYRATKLWNEVTTSFRAGMPLRKHRQHFK
10 20 30
70 80 90 100 110 120
pF1KE3 RHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDK
....::...:::: ... : .:. :: .. : ..... . .. .:.: . . .:...
NP_060 KYGNCFTAGEAVDWLYDLLRNNSNFGP-EVTRQQTIQLLRKFLKNHVIEDIKGR-WGSEN
40 50 60 70 80 90
130 140 150 160 170
pF1KE3 KPTFEDSSCSLYRFT------TIPNQDSQLGKENKLYSPARYADALFKSSDI--RSASLE
:.. .:.:: :.: . .: ..:.. . .. :..:: .. :. . .
NP_060 V----DDNNQLFRFPATSPLKTLPRRYPEL-RKNNIENFSKDKDSIFKLRNLSRRTPKRH
100 110 120 130 140 150
180 190 200 210 220
pF1KE3 DLW------ENLSLKPANSPHVNI--SATLSPQVINEVWQEETIGRLLQLVDLPLLDSLL
: :... . : . : . :: . ..:::. . : .. .: :. ..
NP_060 GLHLSQENGEKIKHEIINEDQENAIDNRELSQEDVEEVWRYVILIYLQTILGVPSLEEVI
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE3 KQQEAVPKIPQPKRQSTMVNSSNYLDRGILKAYSDSQE-DEWLSAAIDCLEYLPDQMVVE
. ....: : : : .: ::.. . :.. .:. .:. :: : . ..
NP_060 NPKQVIP-------QYIMYNMANTSKRGVVILQNKSDDLPHWVLSAMKCLANWPRSNDMN
220 230 240 250 260
290 300 310 320 330 340
pF1KE3 ISRSFPEQPDRTDLVKELLFDAIGRYYSSR-EPLLN-HLSDVHNGIAELLVNGKTEIALE
.: . . ... : .:. :. . ::::. . .. .: :: ..:..
NP_060 -------NPTYVGFERDV-FRTIADYFLDLPEPLLTFEYYELFVNILGLLQPHLERVAID
270 280 290 300 310
350 360 370 380 390
pF1KE3 ATQLLLKLLDFQNREEFRRLLYFMA-VAANPSEFKLQKESDNRMVVKRIFSKAI------
: :: :: ::.... :. ... .. : . ::. .: .. . ::. .
NP_060 ALQLCCLLLPPPNRRKLQLLMRMISRMSQNVDMPKLHDAMGTRSLMIHTFSRCVLCCAEE
320 330 340 350 360 370
400 410 420 430 440
pF1KE3 VDNKNLSKGKTDLLVLFLMDHQKDVFKIPGTLHKIVSVKLMAIQNGRDPNRDAG------
:: .: :. :: :::::.......:. :. : .: ...:. : :
NP_060 VDLDELLAGR---LVSFLMDHHQEILQVPSYLQTAVEKHLDYLKKGHIENPGDGLFAPLP
380 390 400 410 420 430
450 460 470 480 490 500
pF1KE3 -YIYCQRIDQRDYSNNIEKTTKDELLNLLKTLDEDSKLSAKEKKKLLGQFYKCHPDIFIE
: ::..:. ...... .:.. . .::... .. .: :::.: : :: : .: :. .
NP_060 TYSYCKQISAQEFDEQKVSTSQAAIAELLENIIKNRSLPLKEKRKKLKQFQKEYPLIYQK
440 450 460 470 480 490
510
pF1KE3 HFGD
.:
NP_060 RFPTTESEAALFGDKPTIKQPMLILRKPKFRSLR
500 510 520
>>NP_060839 (OMIM: 616073) DEP domain-containing protein (529 aa)
initn: 358 init1: 127 opt: 402 Z-score: 470.8 bits: 96.7 E(85289): 1.7e-19
Smith-Waterman score: 457; 25.2% identity (55.3% similar) in 508 aa overlap (28-509:6-489)
10 20 30 40 50 60
pF1KE3 MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLK
:. :. :: .:. .. ..... ..:.: :.:
NP_060 MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFK
10 20 30
70 80 90 100 110 120
pF1KE3 RHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDK
.. ::...:::: . : .. :: .. : ..:.. . .. .:.: . ::
NP_060 SYEHCFTAAEAVDWLHELLRCSQNFGP-EVTRKQTVQLLKKFLKNHVIEDIK----GKWG
40 50 60 70 80 90
130 140 150 160 170
pF1KE3 KPTFEDSSCSLYRFTTI----PNQDSQLGKENKLYSPARYADALFKSSD----IRSASLE
. :::. :::: : . .... . : .. : .:. .: . ..
NP_060 EEDFEDNR-HLYRFPPSSPLKPYPKKPPNQKDVIKFP-EWNDLPPGTSQENIPVRPVVMN
100 110 120 130 140 150
180 190 200 210 220
pF1KE3 -DLW-ENLSLKPANSPHVNI--SATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQE
..: . :. .. : . :. ..:.:. :.. : ... : ::: :
NP_060 SEMWYKRHSIAIGEVPACRLVHRRQLTEANVEEIWKSMTLSYLQKILGL---DSL----E
160 170 180 190 200
230 240 250 260 270 280
pF1KE3 AVPKIPQPKRQSTMVNSSNYLDRGILKAYSDSQE-DEWLSAAIDCLEYLPDQMVVEISRS
: . . . . : . .:.. . :.: .:. .:. :: :. :
NP_060 EVLDVKLVNSKFIIHNVYSVSKQGVVILDDKSKELPHWVLSAMKCLANWPNC-------S
210 220 230 240 250
290 300 310 320 330 340
pF1KE3 FPEQPDRTDLVKELLFDAIGRYYSS-REPLLN-HLSDVHNGIAELLVNGKTEIALEATQL
.:: . :.. : .:. ::. .::::. :: :. .. :: : ..:.:: :.
NP_060 DLKQPMYLGFEKDV-FKTIADYYGHLKEPLLTFHLFDAFVSVLGLL--QKEKVAVEAFQI
260 270 280 290 300 310
350 360 370 380 390 400
pF1KE3 LLKLLDFQNREEFRRLLYFMA-VAANPSEFKLQKESDNRMVVKRIFSKAIV---DNKNLS
:: .::.... :. .:: . : : .: .. . ::. :. :. .:.
NP_060 CCLLLPPENRRKLQLLMRMMARICLNKEMPPLCDGFGTRTLMVQTFSRCILCSKDEVDLD
320 330 340 350 360 370
410 420 430 440 450
pF1KE3 KGKTDLLVLFLMDHQKDVFKIPGTLHKIVSVKLMAIQ--NGRDPNRDAGYI-----YCQR
. . :: ::::. ....:.: .:. . .. .. . . :. : .:..
NP_060 ELLAARLVTFLMDNYQEILKVPLALQTSIEERVAHLRRVQIKYPGADMDITLSAPSFCRQ
380 390 400 410 420 430
460 470 480 490 500 510
pF1KE3 IDQRDYSNNIEKTTKDELLNLLKTLDEDSKLSAKEKKKLLGQFYKCHPDIFIEHFGD
:. ... . ... : ::. . :.::: ::::: : :: : .:... :.:
NP_060 ISPEEFEYQRSYGSQEPLAALLEEVITDAKLSNKEKKKKLKQFQKSYPEVYQERFPTPES
440 450 460 470 480 490
NP_060 AALLFPEKPKPKPQLLMWALKKPFQPFQRTRSFRM
500 510 520
>>XP_011541811 (OMIM: 616073) PREDICTED: DEP domain-cont (514 aa)
initn: 336 init1: 112 opt: 304 Z-score: 356.2 bits: 75.5 E(85289): 4.2e-13
Smith-Waterman score: 435; 24.9% identity (55.2% similar) in 498 aa overlap (38-509:1-474)
10 20 30 40 50 60
pF1KE3 AAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLKRHNDCFV
.:. .. ..... ..:.: :.: .. ::.
XP_011 MWNETVELFRAKMPLRKHRCRFKSYEHCFT
10 20 30
70 80 90 100 110 120
pF1KE3 GSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDKKPTFEDS
..:::: . : .. :: .. : ..:.. . .. .:.: . :: . :::.
XP_011 AAEAVDWLHELLRCSQNFGP-EVTRKQTVQLLKKFLKNHVIEDIK----GKWGEEDFEDN
40 50 60 70 80
130 140 150 160 170
pF1KE3 SCSLYRFTTI----PNQDSQLGKENKLYSPARYADALFKSSD----IRSASLE-DLW-EN
:::: : . .... . : .. : .:. .: . .. ..: .
XP_011 R-HLYRFPPSSPLKPYPKKPPNQKDVIKFP-EWNDLPPGTSQENIPVRPVVMNSEMWYKR
90 100 110 120 130 140
180 190 200 210 220 230
pF1KE3 LSLKPANSPHVNI--SATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQEAVPKIPQ
:. .. : . :. ..:.:. :.. : ... : ::: : : .
XP_011 HSIAIGEVPACRLVHRRQLTEANVEEIWKSMTLSYLQKILGL---DSL----EEVLDVKL
150 160 170 180 190
240 250 260 270 280 290
pF1KE3 PKRQSTMVNSSNYLDRGILKAYSDSQE-DEWLSAAIDCLEYLPDQMVVEISRSFPEQPDR
. . . : . .:.. . :.: .:. .:. :: :. : .::
XP_011 VNSKFIIHNVYSVSKQGVVILDDKSKELPHWVLSAMKCLANWPNC-------SDLKQPMY
200 210 220 230 240
300 310 320 330 340 350
pF1KE3 TDLVKELLFDAIGRYYSS-REPLLN-HLSDVHNGIAELLVNGKTEIALEATQLLLKLLDF
. :.. : .:. ::. .::::. :: :. .. :: : ..:.:: :. ::
XP_011 LGFEKDV-FKTIADYYGHLKEPLLTFHLFDAFVSVLGLL--QKEKVAVEAFQICCLLLPP
250 260 270 280 290 300
360 370 380 390 400
pF1KE3 QNREEFRRLLYFMA-VAANPSEFKLQKESDNRMVVKRIFSKAIV---DNKNLSKGKTDLL
.::.... :. .:: . : : .: .. . ::. :. :. .:.. . :
XP_011 ENRRKLQLLMRMMARICLNKEMPPLCDGFGTRTLMVQTFSRCILCSKDEVDLDELLAARL
310 320 330 340 350 360
410 420 430 440 450 460
pF1KE3 VLFLMDHQKDVFKIPGTLHKIVSVKLMAIQ--NGRDPNRDAGYI-----YCQRIDQRDYS
: ::::. ....:.: .:. . .. .. . . :. : .:..:. ...
XP_011 VTFLMDNYQEILKVPLALQTSIEERVAHLRRVQIKYPGADMDITLSAPSFCRQISPEEFE
370 380 390 400 410 420
470 480 490 500 510
pF1KE3 NNIEKTTKDELLNLLKTLDEDSKLSAKEKKKLLGQFYKCHPDIFIEHFGD
. ... : ::. . :.::: ::::: : :: : .:... :.:
XP_011 YQRSYGSQEPLAALLEEVITDAKLSNKEKKKKLKQFQKSYPEVYQERFPTPESAALLFPE
430 440 450 460 470 480
XP_011 KPKPKPQLLMWALKKPFQPFQRTRSFRM
490 500 510
>>NP_001138680 (OMIM: 616073) DEP domain-containing prot (467 aa)
initn: 260 init1: 127 opt: 292 Z-score: 342.8 bits: 72.9 E(85289): 2.4e-12
Smith-Waterman score: 347; 25.1% identity (55.1% similar) in 419 aa overlap (28-427:6-400)
10 20 30 40 50 60
pF1KE3 MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLK
:. :. :: .:. .. ..... ..:.: :.:
NP_001 MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFK
10 20 30
70 80 90 100 110 120
pF1KE3 RHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDK
.. ::...:::: . : .. :: .. : ..:.. . .. .:.: . ::
NP_001 SYEHCFTAAEAVDWLHELLRCSQNFGP-EVTRKQTVQLLKKFLKNHVIEDIK----GKWG
40 50 60 70 80 90
130 140 150 160 170
pF1KE3 KPTFEDSSCSLYRFTTI----PNQDSQLGKENKLYSPARYADALFKSSD----IRSASLE
. :::. :::: : . .... . : .. : .:. .: . ..
NP_001 EEDFEDNR-HLYRFPPSSPLKPYPKKPPNQKDVIKFP-EWNDLPPGTSQENIPVRPVVMN
100 110 120 130 140 150
180 190 200 210 220
pF1KE3 -DLW-ENLSLKPANSPHVNI--SATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQE
..: . :. .. : . :. ..:.:. :.. : ... : ::: :
NP_001 SEMWYKRHSIAIGEVPACRLVHRRQLTEANVEEIWKSMTLSYLQKILGL---DSL----E
160 170 180 190 200
230 240 250 260 270 280
pF1KE3 AVPKIPQPKRQSTMVNSSNYLDRGILKAYSDSQE-DEWLSAAIDCLEYLPDQMVVEISRS
: . . . . : . .:.. . :.: .:. .:. :: :. :
NP_001 EVLDVKLVNSKFIIHNVYSVSKQGVVILDDKSKELPHWVLSAMKCLANWPNC-------S
210 220 230 240 250
290 300 310 320 330 340
pF1KE3 FPEQPDRTDLVKELLFDAIGRYYSS-REPLLN-HLSDVHNGIAELLVNGKTEIALEATQL
.:: . :.. : .:. ::. .::::. :: :. .. :: : ..:.:: :.
NP_001 DLKQPMYLGFEKDV-FKTIADYYGHLKEPLLTFHLFDAFVSVLGLL--QKEKVAVEAFQI
260 270 280 290 300 310
350 360 370 380 390 400
pF1KE3 LLKLLDFQNREEFRRLLYFMA-VAANPSEFKLQKESDNRMVVKRIFSKAIV---DNKNLS
:: .::.... :. .:: . : : .: .. . ::. :. :. .:.
NP_001 CCLLLPPENRRKLQLLMRMMARICLNKEMPPLCDGFGTRTLMVQTFSRCILCSKDEVDLD
320 330 340 350 360 370
410 420 430 440 450 460
pF1KE3 KGKTDLLVLFLMDHQKDVFKIPGTLHKIVSVKLMAIQNGRDPNRDAGYIYCQRIDQRDYS
. . :: ::::. ....:.: .:.
NP_001 ELLAARLVTFLMDNYQEILKVPLALQTSIEERVAHLRRVQFQKSYPEVYQERFPTPESAA
380 390 400 410 420 430
>>NP_001107592 (OMIM: 612002) DEP domain-containing prot (811 aa)
initn: 342 init1: 140 opt: 251 Z-score: 291.0 bits: 64.1 E(85289): 1.8e-09
Smith-Waterman score: 266; 23.4% identity (58.6% similar) in 273 aa overlap (23-277:7-258)
10 20 30 40 50 60
pF1KE3 MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLK
::: :. :: .:. . ..... . ..:.:...:
NP_001 MESQGVPPG------PYRATKLWNEVTTSFRAGMPLRKHRQHFK
10 20 30
70 80 90 100 110 120
pF1KE3 RHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDK
....::...:::: ... : .:. :: .. : ..... . .. .:.: . . .:...
NP_001 KYGNCFTAGEAVDWLYDLLRNNSNFGP-EVTRQQTIQLLRKFLKNHVIEDIKGR-WGSEN
40 50 60 70 80 90
130 140 150 160 170
pF1KE3 KPTFEDSSCSLYRFT------TIPNQDSQLGKENKLYSPARYADALFKSSDI--RSASLE
:.. .:.:: :.: . .: ..:.. . .. :..:: .. :. . .
NP_001 V----DDNNQLFRFPATSPLKTLPRRYPEL-RKNNIENFSKDKDSIFKLRNLSRRTPKRH
100 110 120 130 140 150
180 190 200 210 220
pF1KE3 DLW------ENLSLKPANSPHVNI--SATLSPQVINEVWQEETIGRLLQLVDLPLLDSLL
: :... . : . : . :: . ..:::. . : .. .: :. ..
NP_001 GLHLSQENGEKIKHEIINEDQENAIDNRELSQEDVEEVWRYVILIYLQTILGVPSLEEVI
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE3 KQQEAVPKIPQPKRQSTMVNSSNYLDRG--ILKAYSDSQEDEWLSAAIDCLEYLPDQMVV
. ....: : : : .: :: ::. ::. .:. .:. :: :
NP_001 NPKQVIP-------QYIMYNMANTSKRGVVILQNKSDDLP-HWVLSAMKCLANWPRSNDM
220 230 240 250 260
290 300 310 320 330 340
pF1KE3 EISRSFPEQPDRTDLVKELLFDAIGRYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEA
NP_001 NNPTYVGFERDVFRTIADYFLDLPEPLLTFEYYELFVNILVVCGYITVSDRSSGIHKIQD
270 280 290 300 310 320
>--
initn: 240 init1: 115 opt: 240 Z-score: 278.1 bits: 61.7 E(85289): 9.4e-09
Smith-Waterman score: 240; 27.6% identity (60.1% similar) in 203 aa overlap (321-509:580-779)
300 310 320 330 340 350
pF1KE3 QPDRTDLVKELLFDAIGRYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEATQLLLKLL
:.. .: :: ..:..: :: ::
NP_001 ESELGESSATINKRLCKSTIELSENSLLPASSMLTGTQSLLQPHLERVAIDALQLCCLLL
550 560 570 580 590 600
360 370 380 390 400
pF1KE3 DFQNREEFRRLLYFMA-VAANPSEFKLQKESDNRMVVKRIFSKAI------VDNKNLSKG
::.... :. ... .. : . ::. .: .. . ::. . :: .: :
NP_001 PPPNRRKLQLLMRMISRMSQNVDMPKLHDAMGTRSLMIHTFSRCVLCCAEEVDLDELLAG
610 620 630 640 650 660
410 420 430 440 450
pF1KE3 KTDLLVLFLMDHQKDVFKIPGTLHKIVSVKLMAIQNGRDPNRDAG-------YIYCQRID
. :: :::::.......:. :. : .: ...:. : : : ::..:.
NP_001 R---LVSFLMDHHQEILQVPSYLQTAVEKHLDYLKKGHIENPGDGLFAPLPTYSYCKQIS
670 680 690 700 710 720
460 470 480 490 500 510
pF1KE3 QRDYSNNIEKTTKDELLNLLKTLDEDSKLSAKEKKKLLGQFYKCHPDIFIEHFGD
...... .:.. . .::... .. .: :::.: : :: : .: :. ..:
NP_001 AQEFDEQKVSTSQAAIAELLENIIKNRSLPLKEKRKKLKQFQKEYPLIYQKRFPTTESEA
730 740 750 760 770 780
NP_001 ALFGDKPTIKQPMLILRKPKFRSLR
790 800 810
>>XP_011541812 (OMIM: 616073) PREDICTED: DEP domain-cont (347 aa)
initn: 154 init1: 127 opt: 235 Z-score: 278.0 bits: 60.5 E(85289): 9.6e-09
Smith-Waterman score: 243; 23.3% identity (54.0% similar) in 335 aa overlap (28-347:6-318)
10 20 30 40 50 60
pF1KE3 MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLK
:. :. :: .:. .. ..... ..:.: :.:
XP_011 MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFK
10 20 30
70 80 90 100 110 120
pF1KE3 RHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDK
.. ::...:::: . : .. :: .. : ..:.. . .. .:.: . ::
XP_011 SYEHCFTAAEAVDWLHELLRCSQNFGP-EVTRKQTVQLLKKFLKNHVIEDIK----GKWG
40 50 60 70 80 90
130 140 150 160 170
pF1KE3 KPTFEDSSCSLYRFTTI----PNQDSQLGKENKLYSPARYADALFKSSD----IRSASLE
. :::. :::: : . .... . : .. : .:. .: . ..
XP_011 EEDFEDNR-HLYRFPPSSPLKPYPKKPPNQKDVIKFP-EWNDLPPGTSQENIPVRPVVMN
100 110 120 130 140 150
180 190 200 210 220
pF1KE3 -DLW-ENLSLKPANSPHVNI--SATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQE
..: . :. .. : . :. ..:.:. :.. : ... : ::: :
XP_011 SEMWYKRHSIAIGEVPACRLVHRRQLTEANVEEIWKSMTLSYLQKILGL---DSL----E
160 170 180 190 200
230 240 250 260 270 280
pF1KE3 AVPKIPQPKRQSTMVNSSNYLDRGILKAYSDSQE-DEWLSAAIDCLEYLPDQMVVEISRS
: . . . . : . .:.. . :.: .:. .:. :: :. :
XP_011 EVLDVKLVNSKFIIHNVYSVSKQGVVILDDKSKELPHWVLSAMKCLANWPNC-------S
210 220 230 240 250
290 300 310 320 330 340
pF1KE3 FPEQPDRTDLVKELLFDAIGRYYSS-REPLLN-HLSDVHNGIAELLVNGKTEIALEATQL
.:: . :.. : .:. ::. .::::. :: :. .. .:. . . . : :..
XP_011 DLKQPMYLGFEKDV-FKTIADYYGHLKEPLLTFHLFDAFVSVLDLVSTWSLQGAGESSPS
260 270 280 290 300 310
350 360 370 380 390 400
pF1KE3 LLKLLDFQNREEFRRLLYFMAVAANPSEFKLQKESDNRMVVKRIFSKAIVDNKNLSKGKT
:.
XP_011 LMLSRIHSGSHEVDNVWEHVISLRRNLPHFC
320 330 340
>>XP_016865118 (OMIM: 616073) PREDICTED: DEP domain-cont (330 aa)
initn: 153 init1: 127 opt: 225 Z-score: 266.6 bits: 58.3 E(85289): 4.1e-08
Smith-Waterman score: 233; 23.6% identity (53.5% similar) in 318 aa overlap (28-330:6-301)
10 20 30 40 50 60
pF1KE3 MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLK
:. :. :: .:. .. ..... ..:.: :.:
XP_016 MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFK
10 20 30
70 80 90 100 110 120
pF1KE3 RHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDK
.. ::...:::: . : .. :: .. : ..:.. . .. .:.: . ::
XP_016 SYEHCFTAAEAVDWLHELLRCSQNFGP-EVTRKQTVQLLKKFLKNHVIEDIK----GKWG
40 50 60 70 80 90
130 140 150 160 170
pF1KE3 KPTFEDSSCSLYRFTTI----PNQDSQLGKENKLYSPARYADALFKSSD----IRSASLE
. :::. :::: : . .... . : .. : .:. .: . ..
XP_016 EEDFEDNR-HLYRFPPSSPLKPYPKKPPNQKDVIKFP-EWNDLPPGTSQENIPVRPVVMN
100 110 120 130 140 150
180 190 200 210 220
pF1KE3 -DLW-ENLSLKPANSPHVNI--SATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQE
..: . :. .. : . :. ..:.:. :.. : ... : ::: :
XP_016 SEMWYKRHSIAIGEVPACRLVHRRQLTEANVEEIWKSMTLSYLQKILGL---DSL----E
160 170 180 190 200
230 240 250 260 270 280
pF1KE3 AVPKIPQPKRQSTMVNSSNYLDRGILKAYSDSQE-DEWLSAAIDCLEYLPDQMVVEISRS
: . . . . : . .:.. . :.: .:. .:. :: :. :
XP_016 EVLDVKLVNSKFIIHNVYSVSKQGVVILDDKSKELPHWVLSAMKCLANWPNC-------S
210 220 230 240 250
290 300 310 320 330 340
pF1KE3 FPEQPDRTDLVKELLFDAIGRYYSS-REPLLN-HLSDVHNGIAELLVNGKTEIALEATQL
.:: . :.. : .:. ::. .::::. :: :. .. :
XP_016 DLKQPMYLGFEKDV-FKTIADYYGHLKEPLLTFHLFDAFVSVLALKMWNQPTCPGTDEEI
260 270 280 290 300 310
350 360 370 380 390 400
pF1KE3 LLKLLDFQNREEFRRLLYFMAVAANPSEFKLQKESDNRMVVKRIFSKAIVDNKNLSKGKT
XP_016 KKMQCVYTVECSSP
320 330
511 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 08:36:02 2016 done: Sun Nov 6 08:36:04 2016
Total Scan time: 8.750 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]