FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2281, 843 aa 1>>>pF1KE2281 843 - 843 aa - 843 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.7934+/-0.000359; mu= 6.2364+/- 0.023 mean_var=230.6218+/-47.351, 0's: 0 Z-trim(121.5): 33 B-trim: 735 in 1/55 Lambda= 0.084455 statistics sampled from 38122 (38158) to 38122 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.76), E-opt: 0.2 (0.447), width: 16 Scan time: 14.120 The best scores are: opt bits E(85289) NP_064590 (OMIM: 611748) OTU domain-containing pro ( 843) 5792 719.2 2e-206 XP_016857340 (OMIM: 611748) PREDICTED: OTU domain- ( 714) 4933 614.4 5.6e-175 XP_016857339 (OMIM: 611748) PREDICTED: OTU domain- ( 764) 4890 609.2 2.2e-173 XP_011508086 (OMIM: 611748) PREDICTED: OTU domain- ( 852) 3116 393.1 2.8e-108 XP_011508087 (OMIM: 611748) PREDICTED: OTU domain- ( 852) 3116 393.1 2.8e-108 XP_011508085 (OMIM: 611748) PREDICTED: OTU domain- ( 852) 3116 393.1 2.8e-108 XP_011508084 (OMIM: 611748) PREDICTED: OTU domain- ( 852) 3116 393.1 2.8e-108 XP_011508089 (OMIM: 611748) PREDICTED: OTU domain- ( 773) 2830 358.2 8e-98 XP_011508088 (OMIM: 611748) PREDICTED: OTU domain- ( 773) 2830 358.2 8e-98 XP_011508090 (OMIM: 611748) PREDICTED: OTU domain- ( 773) 2830 358.2 8e-98 NP_570971 (OMIM: 612024) OTU domain-containing pro ( 926) 2156 276.2 4.8e-73 NP_001316836 (OMIM: 612024) OTU domain-containing ( 425) 1950 250.8 9.8e-66 XP_011534398 (OMIM: 191163,616744) PREDICTED: tumo ( 689) 344 55.3 1.1e-06 XP_005267176 (OMIM: 191163,616744) PREDICTED: tumo ( 790) 344 55.3 1.2e-06 NP_001257437 (OMIM: 191163,616744) tumor necrosis ( 790) 344 55.3 1.2e-06 NP_001257436 (OMIM: 191163,616744) tumor necrosis ( 790) 344 55.3 1.2e-06 XP_011534397 (OMIM: 191163,616744) PREDICTED: tumo ( 790) 344 55.3 1.2e-06 NP_006281 (OMIM: 191163,616744) tumor necrosis fac ( 790) 344 55.3 1.2e-06 XP_011538189 (OMIM: 611749) PREDICTED: ubiquitin t ( 248) 244 42.7 0.0024 XP_016871847 (OMIM: 611749) PREDICTED: ubiquitin t ( 382) 244 42.9 0.0034 NP_060050 (OMIM: 611749) ubiquitin thioesterase ZR ( 708) 244 43.1 0.0053 XP_016871846 (OMIM: 611749) PREDICTED: ubiquitin t ( 708) 244 43.1 0.0053 XP_005269983 (OMIM: 611749) PREDICTED: ubiquitin t ( 708) 244 43.1 0.0053 XP_005269982 (OMIM: 611749) PREDICTED: ubiquitin t ( 734) 244 43.1 0.0055 XP_006717970 (OMIM: 611749) PREDICTED: ubiquitin t ( 734) 244 43.1 0.0055 >>NP_064590 (OMIM: 611748) OTU domain-containing protein (843 aa) initn: 5792 init1: 5792 opt: 5792 Z-score: 3827.1 bits: 719.2 E(85289): 2e-206 Smith-Waterman score: 5792; 100.0% identity (100.0% similar) in 843 aa overlap (1-843:1-843) 10 20 30 40 50 60 pF1KE2 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 KLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRSTPESGDSDKESVGSSSTSNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 KLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRSTPESGDSDKESVGSSSTSNE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 GGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSKPGGVGTGLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 GGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSKPGGVGTGLG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 GSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQEVMQSLSILR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 GSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQEVMQSLSILR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 TAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERKIMNGGIGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 TAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERKIMNGGIGGG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 PPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEPRRQLAGGPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 PPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEPRRQLAGGPC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 VGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRVADSYSNGYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 VGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRVADSYSNGYR 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 EPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRREREPDGELLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 EPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRREREPDGELLV 790 800 810 820 830 840 pF1KE2 HRF ::: NP_064 HRF >>XP_016857340 (OMIM: 611748) PREDICTED: OTU domain-cont (714 aa) initn: 4933 init1: 4933 opt: 4933 Z-score: 3262.5 bits: 614.4 E(85289): 5.6e-175 Smith-Waterman score: 4933; 100.0% identity (100.0% similar) in 714 aa overlap (130-843:1-714) 100 110 120 130 140 150 pF1KE2 SHASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQS :::::::::::::::::::::::::::::: XP_016 MPICAFQLPDLTVYNEDFRSFIERDLIEQS 10 20 30 160 170 180 190 200 210 pF1KE2 MLVALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLVALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYA 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE2 LMEKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMEKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGAN 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE2 CGGVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CGGVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLE 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE2 VPASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGW 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE2 EWGKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EWGKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPR 280 290 300 310 320 330 460 470 480 490 500 510 pF1KE2 STPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKK 340 350 360 370 380 390 520 530 540 550 560 570 pF1KE2 NMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAE 400 410 420 430 440 450 580 590 600 610 620 630 pF1KE2 SVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERF 460 470 480 490 500 510 640 650 660 670 680 690 pF1KE2 LAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIP 520 530 540 550 560 570 700 710 720 730 740 750 pF1KE2 RPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGL 580 590 600 610 620 630 760 770 780 790 800 810 pF1KE2 HRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFC 640 650 660 670 680 690 820 830 840 pF1KE2 SCCYREELRRREREPDGELLVHRF :::::::::::::::::::::::: XP_016 SCCYREELRRREREPDGELLVHRF 700 710 >>XP_016857339 (OMIM: 611748) PREDICTED: OTU domain-cont (764 aa) initn: 4890 init1: 4890 opt: 4890 Z-score: 3233.7 bits: 609.2 E(85289): 2.2e-173 Smith-Waterman score: 4890; 99.4% identity (99.9% similar) in 712 aa overlap (132-843:53-764) 110 120 130 140 150 160 pF1KE2 ASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSML . .:.::::::::::::::::::::::::: XP_016 VRGVVAPGPLKKGFLTESLLALPDPSSSGRMTSFKLPDLTVYNEDFRSFIERDLIEQSML 30 40 50 60 70 80 170 180 190 200 210 220 pF1KE2 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM 90 100 110 120 130 140 230 240 250 260 270 280 pF1KE2 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG 150 160 170 180 190 200 290 300 310 320 330 340 pF1KE2 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP 210 220 230 240 250 260 350 360 370 380 390 400 pF1KE2 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW 270 280 290 300 310 320 410 420 430 440 450 460 pF1KE2 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRST 330 340 350 360 370 380 470 480 490 500 510 520 pF1KE2 PESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNM 390 400 410 420 430 440 530 540 550 560 570 580 pF1KE2 GGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESV 450 460 470 480 490 500 590 600 610 620 630 640 pF1KE2 GNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLA 510 520 530 540 550 560 650 660 670 680 690 700 pF1KE2 EQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRP 570 580 590 600 610 620 710 720 730 740 750 760 pF1KE2 SGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHR 630 640 650 660 670 680 770 780 790 800 810 820 pF1KE2 GALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSC 690 700 710 720 730 740 830 840 pF1KE2 CYREELRRREREPDGELLVHRF :::::::::::::::::::::: XP_016 CYREELRRREREPDGELLVHRF 750 760 >>XP_011508086 (OMIM: 611748) PREDICTED: OTU domain-cont (852 aa) initn: 5778 init1: 2977 opt: 3116 Z-score: 2065.0 bits: 393.1 E(85289): 2.8e-108 Smith-Waterman score: 5764; 98.9% identity (98.9% similar) in 852 aa overlap (1-843:1-852) 10 20 30 40 50 60 pF1KE2 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 KLHLLHSYMNVKWIPLSSDAQ---------APLAQPESPTASAGDEPRSTPESGDSDKES ::::::::::::::::::::: :::::::::::::::::::::::::::::: XP_011 KLHLLHSYMNVKWIPLSSDAQVKTSPTSTLAPLAQPESPTASAGDEPRSTPESGDSDKES 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE2 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE2 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE2 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE2 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE2 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE2 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE 790 800 810 820 830 840 840 pF1KE2 REPDGELLVHRF :::::::::::: XP_011 REPDGELLVHRF 850 >>XP_011508087 (OMIM: 611748) PREDICTED: OTU domain-cont (852 aa) initn: 5778 init1: 2977 opt: 3116 Z-score: 2065.0 bits: 393.1 E(85289): 2.8e-108 Smith-Waterman score: 5764; 98.9% identity (98.9% similar) in 852 aa overlap (1-843:1-852) 10 20 30 40 50 60 pF1KE2 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 KLHLLHSYMNVKWIPLSSDAQ---------APLAQPESPTASAGDEPRSTPESGDSDKES ::::::::::::::::::::: :::::::::::::::::::::::::::::: XP_011 KLHLLHSYMNVKWIPLSSDAQVKTSPTSTLAPLAQPESPTASAGDEPRSTPESGDSDKES 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE2 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE2 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE2 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE2 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE2 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE2 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE 790 800 810 820 830 840 840 pF1KE2 REPDGELLVHRF :::::::::::: XP_011 REPDGELLVHRF 850 >>XP_011508085 (OMIM: 611748) PREDICTED: OTU domain-cont (852 aa) initn: 5778 init1: 2977 opt: 3116 Z-score: 2065.0 bits: 393.1 E(85289): 2.8e-108 Smith-Waterman score: 5764; 98.9% identity (98.9% similar) in 852 aa overlap (1-843:1-852) 10 20 30 40 50 60 pF1KE2 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 KLHLLHSYMNVKWIPLSSDAQ---------APLAQPESPTASAGDEPRSTPESGDSDKES ::::::::::::::::::::: :::::::::::::::::::::::::::::: XP_011 KLHLLHSYMNVKWIPLSSDAQVKTSPTSTLAPLAQPESPTASAGDEPRSTPESGDSDKES 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE2 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE2 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE2 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE2 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE2 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE2 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE 790 800 810 820 830 840 840 pF1KE2 REPDGELLVHRF :::::::::::: XP_011 REPDGELLVHRF 850 >>XP_011508084 (OMIM: 611748) PREDICTED: OTU domain-cont (852 aa) initn: 5778 init1: 2977 opt: 3116 Z-score: 2065.0 bits: 393.1 E(85289): 2.8e-108 Smith-Waterman score: 5764; 98.9% identity (98.9% similar) in 852 aa overlap (1-843:1-852) 10 20 30 40 50 60 pF1KE2 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 KLHLLHSYMNVKWIPLSSDAQ---------APLAQPESPTASAGDEPRSTPESGDSDKES ::::::::::::::::::::: :::::::::::::::::::::::::::::: XP_011 KLHLLHSYMNVKWIPLSSDAQVKTSPTSTLAPLAQPESPTASAGDEPRSTPESGDSDKES 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE2 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE2 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE2 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERK 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE2 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEP 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE2 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRV 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE2 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRRE 790 800 810 820 830 840 840 pF1KE2 REPDGELLVHRF :::::::::::: XP_011 REPDGELLVHRF 850 >>XP_011508089 (OMIM: 611748) PREDICTED: OTU domain-cont (773 aa) initn: 4876 init1: 2815 opt: 2830 Z-score: 1877.2 bits: 358.2 E(85289): 8e-98 Smith-Waterman score: 4862; 98.2% identity (98.6% similar) in 721 aa overlap (132-843:53-773) 110 120 130 140 150 160 pF1KE2 ASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSML . .:.::::::::::::::::::::::::: XP_011 VRGVVAPGPLKKGFLTESLLALPDPSSSGRMTSFKLPDLTVYNEDFRSFIERDLIEQSML 30 40 50 60 70 80 170 180 190 200 210 220 pF1KE2 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM 90 100 110 120 130 140 230 240 250 260 270 280 pF1KE2 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG 150 160 170 180 190 200 290 300 310 320 330 340 pF1KE2 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP 210 220 230 240 250 260 350 360 370 380 390 400 pF1KE2 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW 270 280 290 300 310 320 410 420 430 440 450 pF1KE2 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQ---------APLAQPESPTA :::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_011 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQVKTSPTSTLAPLAQPESPTA 330 340 350 360 370 380 460 470 480 490 500 510 pF1KE2 SAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKT 390 400 410 420 430 440 520 530 540 550 560 570 pF1KE2 LGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPV 450 460 470 480 490 500 580 590 600 610 620 630 pF1KE2 SEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYL 510 520 530 540 550 560 640 650 660 670 680 690 pF1KE2 SDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGY 570 580 590 600 610 620 700 710 720 730 740 750 pF1KE2 PGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPG 630 640 650 660 670 680 760 770 780 790 800 810 pF1KE2 SHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGH 690 700 710 720 730 740 820 830 840 pF1KE2 PETNNFCSCCYREELRRREREPDGELLVHRF ::::::::::::::::::::::::::::::: XP_011 PETNNFCSCCYREELRRREREPDGELLVHRF 750 760 770 >>XP_011508088 (OMIM: 611748) PREDICTED: OTU domain-cont (773 aa) initn: 4876 init1: 2815 opt: 2830 Z-score: 1877.2 bits: 358.2 E(85289): 8e-98 Smith-Waterman score: 4862; 98.2% identity (98.6% similar) in 721 aa overlap (132-843:53-773) 110 120 130 140 150 160 pF1KE2 ASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSML . .:.::::::::::::::::::::::::: XP_011 VRGVVAPGPLKKGFLTESLLALPDPSSSGRMTSFKLPDLTVYNEDFRSFIERDLIEQSML 30 40 50 60 70 80 170 180 190 200 210 220 pF1KE2 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM 90 100 110 120 130 140 230 240 250 260 270 280 pF1KE2 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG 150 160 170 180 190 200 290 300 310 320 330 340 pF1KE2 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP 210 220 230 240 250 260 350 360 370 380 390 400 pF1KE2 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW 270 280 290 300 310 320 410 420 430 440 450 pF1KE2 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQ---------APLAQPESPTA :::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_011 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQVKTSPTSTLAPLAQPESPTA 330 340 350 360 370 380 460 470 480 490 500 510 pF1KE2 SAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKT 390 400 410 420 430 440 520 530 540 550 560 570 pF1KE2 LGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPV 450 460 470 480 490 500 580 590 600 610 620 630 pF1KE2 SEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYL 510 520 530 540 550 560 640 650 660 670 680 690 pF1KE2 SDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGY 570 580 590 600 610 620 700 710 720 730 740 750 pF1KE2 PGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPG 630 640 650 660 670 680 760 770 780 790 800 810 pF1KE2 SHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGH 690 700 710 720 730 740 820 830 840 pF1KE2 PETNNFCSCCYREELRRREREPDGELLVHRF ::::::::::::::::::::::::::::::: XP_011 PETNNFCSCCYREELRRREREPDGELLVHRF 750 760 770 >>XP_011508090 (OMIM: 611748) PREDICTED: OTU domain-cont (773 aa) initn: 4876 init1: 2815 opt: 2830 Z-score: 1877.2 bits: 358.2 E(85289): 8e-98 Smith-Waterman score: 4862; 98.2% identity (98.6% similar) in 721 aa overlap (132-843:53-773) 110 120 130 140 150 160 pF1KE2 ASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSML . .:.::::::::::::::::::::::::: XP_011 VRGVVAPGPLKKGFLTESLLALPDPSSSGRMTSFKLPDLTVYNEDFRSFIERDLIEQSML 30 40 50 60 70 80 170 180 190 200 210 220 pF1KE2 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALM 90 100 110 120 130 140 230 240 250 260 270 280 pF1KE2 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCG 150 160 170 180 190 200 290 300 310 320 330 340 pF1KE2 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVP 210 220 230 240 250 260 350 360 370 380 390 400 pF1KE2 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEW 270 280 290 300 310 320 410 420 430 440 450 pF1KE2 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQ---------APLAQPESPTA :::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_011 GKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQVKTSPTSTLAPLAQPESPTA 330 340 350 360 370 380 460 470 480 490 500 510 pF1KE2 SAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKT 390 400 410 420 430 440 520 530 540 550 560 570 pF1KE2 LGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPV 450 460 470 480 490 500 580 590 600 610 620 630 pF1KE2 SEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYL 510 520 530 540 550 560 640 650 660 670 680 690 pF1KE2 SDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGY 570 580 590 600 610 620 700 710 720 730 740 750 pF1KE2 PGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPG 630 640 650 660 670 680 760 770 780 790 800 810 pF1KE2 SHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGH 690 700 710 720 730 740 820 830 840 pF1KE2 PETNNFCSCCYREELRRREREPDGELLVHRF ::::::::::::::::::::::::::::::: XP_011 PETNNFCSCCYREELRRREREPDGELLVHRF 750 760 770 843 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 06:13:12 2016 done: Sun Nov 6 06:13:14 2016 Total Scan time: 14.120 Total Display time: 0.290 Function used was FASTA [36.3.4 Apr, 2011]