FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1778, 285 aa 1>>>pF1KE1778 285 - 285 aa - 285 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4122+/-0.000416; mu= 14.0206+/- 0.026 mean_var=59.7106+/-12.081, 0's: 0 Z-trim(110.8): 52 B-trim: 862 in 2/49 Lambda= 0.165977 statistics sampled from 19187 (19223) to 19187 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.601), E-opt: 0.2 (0.225), width: 16 Scan time: 6.690 The best scores are: opt bits E(85289) XP_016856949 (OMIM: 611075) PREDICTED: diphthine m ( 285) 1851 451.8 6.7e-127 NP_057042 (OMIM: 611075) diphthine methyl ester sy ( 285) 1851 451.8 6.7e-127 NP_001070862 (OMIM: 611075) diphthine methyl ester ( 285) 1851 451.8 6.7e-127 NP_001070863 (OMIM: 611075) diphthine methyl ester ( 284) 1834 447.8 1.1e-125 XP_011539871 (OMIM: 611075) PREDICTED: diphthine m ( 239) 1149 283.7 2.3e-76 XP_005270995 (OMIM: 611075) PREDICTED: diphthine m ( 240) 1147 283.2 3.2e-76 XP_005270996 (OMIM: 611075) PREDICTED: diphthine m ( 172) 1143 282.2 4.6e-76 XP_016856950 (OMIM: 611075) PREDICTED: diphthine m ( 172) 1143 282.2 4.6e-76 XP_011539872 (OMIM: 611075) PREDICTED: diphthine m ( 172) 1143 282.2 4.6e-76 XP_006710746 (OMIM: 611075) PREDICTED: diphthine m ( 164) 974 241.8 6.7e-64 XP_005270998 (OMIM: 611075) PREDICTED: diphthine m ( 164) 974 241.8 6.7e-64 XP_016856951 (OMIM: 611075) PREDICTED: diphthine m ( 163) 957 237.7 1.1e-62 >>XP_016856949 (OMIM: 611075) PREDICTED: diphthine methy (285 aa) initn: 1851 init1: 1851 opt: 1851 Z-score: 2399.3 bits: 451.8 E(85289): 6.7e-127 Smith-Waterman score: 1851; 100.0% identity (100.0% similar) in 285 aa overlap (1-285:1-285) 10 20 30 40 50 60 pF1KE1 MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 IYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQM 190 200 210 220 230 240 250 260 270 280 pF1KE1 CTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL ::::::::::::::::::::::::::::::::::::::::::::: XP_016 CTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL 250 260 270 280 >>NP_057042 (OMIM: 611075) diphthine methyl ester syntha (285 aa) initn: 1851 init1: 1851 opt: 1851 Z-score: 2399.3 bits: 451.8 E(85289): 6.7e-127 Smith-Waterman score: 1851; 100.0% identity (100.0% similar) in 285 aa overlap (1-285:1-285) 10 20 30 40 50 60 pF1KE1 MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 VEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 IYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 IYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQM 190 200 210 220 230 240 250 260 270 280 pF1KE1 CTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL ::::::::::::::::::::::::::::::::::::::::::::: NP_057 CTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL 250 260 270 280 >>NP_001070862 (OMIM: 611075) diphthine methyl ester syn (285 aa) initn: 1851 init1: 1851 opt: 1851 Z-score: 2399.3 bits: 451.8 E(85289): 6.7e-127 Smith-Waterman score: 1851; 100.0% identity (100.0% similar) in 285 aa overlap (1-285:1-285) 10 20 30 40 50 60 pF1KE1 MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 IYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQM 190 200 210 220 230 240 250 260 270 280 pF1KE1 CTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL ::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL 250 260 270 280 >>NP_001070863 (OMIM: 611075) diphthine methyl ester syn (284 aa) initn: 1382 init1: 1382 opt: 1834 Z-score: 2377.3 bits: 447.8 E(85289): 1.1e-125 Smith-Waterman score: 1834; 99.6% identity (99.6% similar) in 285 aa overlap (1-285:1-284) 10 20 30 40 50 60 pF1KE1 MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 IYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQM ::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::: NP_001 IYEPPRYMSVNQAAQQLLEIVQNQRIRGEEP-VTEETLCVGLARVGADDQKIAAGTLRQM 190 200 210 220 230 250 260 270 280 pF1KE1 CTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL ::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL 240 250 260 270 280 >>XP_011539871 (OMIM: 611075) PREDICTED: diphthine methy (239 aa) initn: 1149 init1: 1149 opt: 1149 Z-score: 1492.1 bits: 283.7 E(85289): 2.3e-76 Smith-Waterman score: 1149; 98.9% identity (99.4% similar) in 179 aa overlap (1-179:1-179) 10 20 30 40 50 60 pF1KE1 MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::. : XP_011 GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLINYRG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 IYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQM XP_011 DTLCWLSQGWSRRPENCSRHFKANVHCGLGRTIAFLDHHRRQHTSNGDGDAKSVFHTRK 190 200 210 220 230 >>XP_005270995 (OMIM: 611075) PREDICTED: diphthine methy (240 aa) initn: 1147 init1: 1147 opt: 1147 Z-score: 1489.4 bits: 283.2 E(85289): 3.2e-76 Smith-Waterman score: 1147; 97.8% identity (99.4% similar) in 180 aa overlap (1-180:1-180) 10 20 30 40 50 60 pF1KE1 MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.. . XP_005 GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLINSYR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 IYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQM XP_005 GDTLCWLSQGWSRRPENCSRHFKANVHCGLGRTIAFLDHHRRQHTSNGDGDAKSVFHTRK 190 200 210 220 230 240 >>XP_005270996 (OMIM: 611075) PREDICTED: diphthine methy (172 aa) initn: 1143 init1: 1143 opt: 1143 Z-score: 1486.6 bits: 282.2 E(85289): 4.6e-76 Smith-Waterman score: 1143; 100.0% identity (100.0% similar) in 172 aa overlap (114-285:1-172) 90 100 110 120 130 140 pF1KE1 DPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCCGLQLYKFGETVSIVFWTDTWRPE :::::::::::::::::::::::::::::: XP_005 MNAVGCCGLQLYKFGETVSIVFWTDTWRPE 10 20 30 150 160 170 180 190 200 pF1KE1 SFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQN 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE1 QRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPME 100 110 120 130 140 150 270 280 pF1KE1 MEMLSLFSIPENSSESQSINGL :::::::::::::::::::::: XP_005 MEMLSLFSIPENSSESQSINGL 160 170 >>XP_016856950 (OMIM: 611075) PREDICTED: diphthine methy (172 aa) initn: 1143 init1: 1143 opt: 1143 Z-score: 1486.6 bits: 282.2 E(85289): 4.6e-76 Smith-Waterman score: 1143; 100.0% identity (100.0% similar) in 172 aa overlap (114-285:1-172) 90 100 110 120 130 140 pF1KE1 DPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCCGLQLYKFGETVSIVFWTDTWRPE :::::::::::::::::::::::::::::: XP_016 MNAVGCCGLQLYKFGETVSIVFWTDTWRPE 10 20 30 150 160 170 180 190 200 pF1KE1 SFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQN 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE1 QRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPME 100 110 120 130 140 150 270 280 pF1KE1 MEMLSLFSIPENSSESQSINGL :::::::::::::::::::::: XP_016 MEMLSLFSIPENSSESQSINGL 160 170 >>XP_011539872 (OMIM: 611075) PREDICTED: diphthine methy (172 aa) initn: 1143 init1: 1143 opt: 1143 Z-score: 1486.6 bits: 282.2 E(85289): 4.6e-76 Smith-Waterman score: 1143; 100.0% identity (100.0% similar) in 172 aa overlap (114-285:1-172) 90 100 110 120 130 140 pF1KE1 DPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCCGLQLYKFGETVSIVFWTDTWRPE :::::::::::::::::::::::::::::: XP_011 MNAVGCCGLQLYKFGETVSIVFWTDTWRPE 10 20 30 150 160 170 180 190 200 pF1KE1 SFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQN 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE1 QRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPME 100 110 120 130 140 150 270 280 pF1KE1 MEMLSLFSIPENSSESQSINGL :::::::::::::::::::::: XP_011 MEMLSLFSIPENSSESQSINGL 160 170 >>XP_006710746 (OMIM: 611075) PREDICTED: diphthine methy (164 aa) initn: 974 init1: 974 opt: 974 Z-score: 1268.2 bits: 241.8 E(85289): 6.7e-64 Smith-Waterman score: 974; 97.4% identity (98.7% similar) in 153 aa overlap (133-285:12-164) 110 120 130 140 150 160 pF1KE1 IPYRVIHNASIMNAVGCCGLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCL .:. ::::::::::::::::::::::::: XP_006 MLISVMLHSLWLVIHLDTWRPESFFDKVKKNRQNGMHTLCL 10 20 30 40 170 180 190 200 210 220 pF1KE1 LDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGL 50 60 70 80 90 100 230 240 250 260 270 280 pF1KE1 ARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSI 110 120 130 140 150 160 pF1KE1 NGL ::: XP_006 NGL 285 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 11:10:34 2016 done: Sun Nov 6 11:10:35 2016 Total Scan time: 6.690 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]