FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2643, 105 aa 1>>>pF1KE2643 105 - 105 aa - 105 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.4615+/-0.000324; mu= 14.1381+/- 0.020 mean_var=56.0249+/-11.245, 0's: 0 Z-trim(115.5): 47 B-trim: 65 in 1/51 Lambda= 0.171350 statistics sampled from 25942 (25990) to 25942 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.305), width: 16 Scan time: 3.140 The best scores are: opt bits E(85289) NP_003320 (OMIM: 187700) thioredoxin isoform 1 [Ho ( 105) 705 181.6 2e-46 NP_001231867 (OMIM: 187700) thioredoxin isoform 2 ( 85) 300 81.4 2.3e-16 XP_011524565 (OMIM: 603049) PREDICTED: thioredoxin ( 282) 284 77.9 9e-15 NP_004777 (OMIM: 603049) thioredoxin-like protein ( 289) 284 77.9 9.2e-15 XP_016881582 (OMIM: 603049) PREDICTED: thioredoxin ( 289) 284 77.9 9.2e-15 XP_006722643 (OMIM: 603049) PREDICTED: thioredoxin ( 292) 284 77.9 9.3e-15 NP_036605 (OMIM: 609063,616811) thioredoxin, mitoc ( 166) 229 64.1 7.4e-11 XP_006724289 (OMIM: 609063,616811) PREDICTED: thio ( 166) 229 64.1 7.4e-11 XP_005261565 (OMIM: 609063,616811) PREDICTED: thio ( 197) 229 64.2 8.5e-11 NP_006532 (OMIM: 612754) glutaredoxin-3 isoform 1 ( 335) 180 52.2 5.6e-07 NP_001186797 (OMIM: 612754) glutaredoxin-3 isoform ( 335) 180 52.2 5.6e-07 NP_057700 (OMIM: 607421,610852) thioredoxin domain ( 588) 172 50.5 3.4e-06 NP_001139021 (OMIM: 616412) thioredoxin domain-con ( 324) 169 49.5 3.6e-06 NP_110437 (OMIM: 616412) thioredoxin domain-contai ( 432) 169 49.6 4.5e-06 NP_005304 (OMIM: 602046) protein disulfide-isomera ( 505) 155 46.2 5.6e-05 NP_055866 (OMIM: 609170) endoplasmic reticulum res ( 406) 142 42.9 0.00044 NP_001258510 (OMIM: 607987) dnaJ homolog subfamily ( 747) 144 43.6 0.0005 NP_061854 (OMIM: 607987) dnaJ homolog subfamily C ( 793) 144 43.6 0.00052 NP_006840 (OMIM: 608012) protein disulfide-isomera ( 525) 136 41.5 0.0015 NP_000909 (OMIM: 112240,176790) protein disulfide- ( 508) 134 41.0 0.0021 XP_011524337 (OMIM: 616102) PREDICTED: protein dis ( 229) 130 39.7 0.0022 XP_011524336 (OMIM: 616102) PREDICTED: protein dis ( 231) 130 39.8 0.0022 NP_006801 (OMIM: 616942) protein disulfide-isomera ( 519) 132 40.5 0.0029 NP_061895 (OMIM: 616102) protein disulfide-isomera ( 454) 130 40.0 0.0037 NP_001269634 (OMIM: 611099) protein disulfide-isom ( 488) 126 39.0 0.0079 NP_001269633 (OMIM: 611099) protein disulfide-isom ( 492) 126 39.0 0.0079 NP_001137484 (OMIM: 616715) thioredoxin-related tr ( 258) 123 38.1 0.0081 NP_057043 (OMIM: 616715) thioredoxin-related trans ( 296) 123 38.1 0.009 >>NP_003320 (OMIM: 187700) thioredoxin isoform 1 [Homo s (105 aa) initn: 705 init1: 705 opt: 705 Z-score: 954.5 bits: 181.6 E(85289): 2e-46 Smith-Waterman score: 705; 100.0% identity (100.0% similar) in 105 aa overlap (1-105:1-105) 10 20 30 40 50 60 pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVD 10 20 30 40 50 60 70 80 90 100 pF1KE2 DCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV ::::::::::::::::::::::::::::::::::::::::::::: NP_003 DCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV 70 80 90 100 >>NP_001231867 (OMIM: 187700) thioredoxin isoform 2 [Hom (85 aa) initn: 300 init1: 300 opt: 300 Z-score: 414.7 bits: 81.4 E(85289): 2.3e-16 Smith-Waterman score: 525; 81.0% identity (81.0% similar) in 105 aa overlap (1-105:1-85) 10 20 30 40 50 60 pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVD ::::::::::::::::::::::::::::::::::::::::::: NP_001 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFH----------------- 10 20 30 40 70 80 90 100 pF1KE2 DCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV :::::::::::::::::::::::::::::::::::::::::: NP_001 ---DVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV 50 60 70 80 >>XP_011524565 (OMIM: 603049) PREDICTED: thioredoxin-lik (282 aa) initn: 284 init1: 284 opt: 284 Z-score: 386.2 bits: 77.9 E(85289): 9e-15 Smith-Waterman score: 284; 41.2% identity (68.6% similar) in 102 aa overlap (2-103:4-105) 10 20 30 40 50 pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVD :: . : :: :..::..:.:: :. :::: : : : :.:.:: ...::::: XP_011 MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVD 10 20 30 40 50 60 60 70 80 90 100 pF1KE2 VDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV : .:: .:. ... ::: ::.. .. ...::. :: :.. XP_011 VHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIP 70 80 90 100 110 120 XP_011 KGYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSM 130 140 150 160 170 180 >>NP_004777 (OMIM: 603049) thioredoxin-like protein 1 [H (289 aa) initn: 284 init1: 284 opt: 284 Z-score: 386.0 bits: 77.9 E(85289): 9.2e-15 Smith-Waterman score: 284; 41.2% identity (68.6% similar) in 102 aa overlap (2-103:4-105) 10 20 30 40 50 pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVD :: . : :: :..::..:.:: :. :::: : : : :.:.:: ...::::: NP_004 MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVD 10 20 30 40 50 60 60 70 80 90 100 pF1KE2 VDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV : .:: .:. ... ::: ::.. .. ...::. :: :.. NP_004 VHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIP 70 80 90 100 110 120 NP_004 KGYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSM 130 140 150 160 170 180 >>XP_016881582 (OMIM: 603049) PREDICTED: thioredoxin-lik (289 aa) initn: 284 init1: 284 opt: 284 Z-score: 386.0 bits: 77.9 E(85289): 9.2e-15 Smith-Waterman score: 284; 41.2% identity (68.6% similar) in 102 aa overlap (2-103:4-105) 10 20 30 40 50 pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVD :: . : :: :..::..:.:: :. :::: : : : :.:.:: ...::::: XP_016 MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVD 10 20 30 40 50 60 60 70 80 90 100 pF1KE2 VDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV : .:: .:. ... ::: ::.. .. ...::. :: :.. XP_016 VHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIP 70 80 90 100 110 120 XP_016 KGYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSM 130 140 150 160 170 180 >>XP_006722643 (OMIM: 603049) PREDICTED: thioredoxin-lik (292 aa) initn: 284 init1: 284 opt: 284 Z-score: 386.0 bits: 77.9 E(85289): 9.3e-15 Smith-Waterman score: 284; 41.2% identity (68.6% similar) in 102 aa overlap (2-103:4-105) 10 20 30 40 50 pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVD :: . : :: :..::..:.:: :. :::: : : : :.:.:: ...::::: XP_006 MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVD 10 20 30 40 50 60 60 70 80 90 100 pF1KE2 VDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV : .:: .:. ... ::: ::.. .. ...::. :: :.. XP_006 VHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIP 70 80 90 100 110 120 XP_006 KGYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSM 130 140 150 160 170 180 >>NP_036605 (OMIM: 609063,616811) thioredoxin, mitochond (166 aa) initn: 127 init1: 115 opt: 229 Z-score: 315.9 bits: 64.1 E(85289): 7.4e-11 Smith-Waterman score: 229; 36.9% identity (71.8% similar) in 103 aa overlap (5-105:64-165) 10 20 30 pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGP :.. ::. . . .. ::::: : :::: NP_036 TPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRV-VNSETPVVVDFHAQWCGP 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE2 CKMIKPFFHSL-SEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGAN ::.. : .... ......:.. .::.:: :.: : ::. .:: .:.:. : .: : . NP_036 CKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIK 100 110 120 130 140 150 100 pF1KE2 KE-KLEATINELV : .::: ...:. NP_036 DEDQLEAFLKKLIG 160 >>XP_006724289 (OMIM: 609063,616811) PREDICTED: thioredo (166 aa) initn: 127 init1: 115 opt: 229 Z-score: 315.9 bits: 64.1 E(85289): 7.4e-11 Smith-Waterman score: 229; 36.9% identity (71.8% similar) in 103 aa overlap (5-105:64-165) 10 20 30 pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGP :.. ::. . . .. ::::: : :::: XP_006 TPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRV-VNSETPVVVDFHAQWCGP 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE2 CKMIKPFFHSL-SEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGAN ::.. : .... ......:.. .::.:: :.: : ::. .:: .:.:. : .: : . XP_006 CKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIK 100 110 120 130 140 150 100 pF1KE2 KE-KLEATINELV : .::: ...:. XP_006 DEDQLEAFLKKLIG 160 >>XP_005261565 (OMIM: 609063,616811) PREDICTED: thioredo (197 aa) initn: 127 init1: 115 opt: 229 Z-score: 314.8 bits: 64.2 E(85289): 8.5e-11 Smith-Waterman score: 229; 36.9% identity (71.8% similar) in 103 aa overlap (5-105:95-196) 10 20 30 pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGP :.. ::. . . .. ::::: : :::: XP_005 TPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRV-VNSETPVVVDFHAQWCGP 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE2 CKMIKPFFHSL-SEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGAN ::.. : .... ......:.. .::.:: :.: : ::. .:: .:.:. : .: : . XP_005 CKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIK 130 140 150 160 170 180 100 pF1KE2 KE-KLEATINELV : .::: ...:. XP_005 DEDQLEAFLKKLIG 190 >>NP_006532 (OMIM: 612754) glutaredoxin-3 isoform 1 [Hom (335 aa) initn: 79 init1: 79 opt: 180 Z-score: 246.2 bits: 52.2 E(85289): 5.6e-07 Smith-Waterman score: 180; 28.0% identity (64.0% similar) in 100 aa overlap (2-101:13-112) 10 20 30 40 pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKY :... : :.: : . .:.:: : : : : ... . :... NP_006 MAAGAAEAAVAAVEEVGSAGQFEELLRLKAKSLLVVHFWAPWAPQCAQMNEVMAELAKEL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE2 SNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV .: :...... .:. . :.. .::: :::..::. ...::. .: . NP_006 PQVSFVKLEAEGVPEVSEKYEISSVPTFLFFKNSQKIDRLDGAHAPELTKKVQRHASSGS 70 80 90 100 110 120 NP_006 FLPSANEHLKEDLNLRLKKLTHAAPCMLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSFD 130 140 150 160 170 180 105 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 17:41:58 2016 done: Tue Nov 8 17:41:58 2016 Total Scan time: 3.140 Total Display time: -0.040 Function used was FASTA [36.3.4 Apr, 2011]