FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0797, 1572 aa 1>>>pF1KE0797 1572 - 1572 aa - 1572 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 17.3907+/-0.000535; mu= -30.1095+/- 0.033 mean_var=821.6823+/-168.803, 0's: 0 Z-trim(124.3): 314 B-trim: 0 in 0/61 Lambda= 0.044743 statistics sampled from 45231 (45595) to 45231 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.775), E-opt: 0.2 (0.535), width: 16 Scan time: 21.580 The best scores are: opt bits E(85289) NP_620614 (OMIM: 600014,601358) probable global tr (1572) 10527 696.2 5.7e-199 NP_003061 (OMIM: 600014,601358) probable global tr (1590) 9415 624.4 2.3e-177 NP_001276325 (OMIM: 600014,601358) probable global (1590) 9415 624.4 2.3e-177 XP_016882657 (OMIM: 603254,613325,614609) PREDICTE (1613) 6400 429.8 9.1e-119 NP_001122320 (OMIM: 603254,613325,614609) transcri (1613) 6400 429.8 9.1e-119 XP_016882656 (OMIM: 603254,613325,614609) PREDICTE (1614) 6364 427.5 4.5e-118 NP_001122319 (OMIM: 603254,613325,614609) transcri (1614) 6364 427.5 4.5e-118 XP_016882655 (OMIM: 603254,613325,614609) PREDICTE (1616) 6320 424.6 3.3e-117 NP_001122318 (OMIM: 603254,613325,614609) transcri (1616) 6320 424.6 3.3e-117 NP_001122317 (OMIM: 603254,613325,614609) transcri (1617) 6313 424.2 4.5e-117 XP_016882654 (OMIM: 603254,613325,614609) PREDICTE (1617) 6313 424.2 4.5e-117 XP_016882653 (OMIM: 603254,613325,614609) PREDICTE (1645) 6217 418.0 3.3e-115 XP_016882651 (OMIM: 603254,613325,614609) PREDICTE (1646) 6217 418.0 3.3e-115 NP_001276326 (OMIM: 600014,601358) probable global (1514) 5900 397.5 4.5e-109 XP_016882652 (OMIM: 603254,613325,614609) PREDICTE (1646) 5584 377.1 6.6e-103 NP_001122316 (OMIM: 603254,613325,614609) transcri (1647) 5584 377.1 6.6e-103 NP_003063 (OMIM: 603254,613325,614609) transcripti (1647) 5584 377.1 6.6e-103 XP_016882650 (OMIM: 603254,613325,614609) PREDICTE (1650) 5584 377.1 6.6e-103 XP_016882649 (OMIM: 603254,613325,614609) PREDICTE (1678) 5584 377.1 6.7e-103 XP_011526500 (OMIM: 603254,613325,614609) PREDICTE (1679) 5584 377.1 6.7e-103 XP_006722908 (OMIM: 603254,613325,614609) PREDICTE (1679) 5584 377.1 6.7e-103 XP_006722909 (OMIM: 603254,613325,614609) PREDICTE (1679) 5584 377.1 6.7e-103 NP_001122321 (OMIM: 603254,613325,614609) transcri (1679) 5584 377.1 6.7e-103 NP_001276327 (OMIM: 600014,601358) probable global ( 248) 1590 118.7 6.2e-26 NP_001276328 (OMIM: 600014,601358) probable global ( 276) 1585 118.4 8.4e-26 NP_001276329 (OMIM: 600014,601358) probable global ( 278) 1585 118.4 8.4e-26 XP_011515862 (OMIM: 189960,214800,608892,612370) P (1621) 1144 90.5 1.2e-16 XP_016869102 (OMIM: 189960,214800,608892,612370) P (2996) 1144 90.7 2e-16 NP_060250 (OMIM: 189960,214800,608892,612370) chro (2997) 1144 90.7 2e-16 XP_011515857 (OMIM: 189960,214800,608892,612370) P (3026) 1144 90.7 2e-16 XP_016869101 (OMIM: 189960,214800,608892,612370) P (3027) 1144 90.7 2e-16 XP_011515856 (OMIM: 189960,214800,608892,612370) P (3027) 1144 90.7 2e-16 XP_011515855 (OMIM: 189960,214800,608892,612370) P (3027) 1144 90.7 2e-16 XP_016879558 (OMIM: 602120) PREDICTED: chromodomai (1888) 1055 84.8 7.4e-15 NP_005843 (OMIM: 602120) chromodomain-helicase-DNA (1966) 1055 84.8 7.7e-15 NP_001005273 (OMIM: 602120) chromodomain-helicase- (2000) 1055 84.8 7.8e-15 XP_006721491 (OMIM: 602120) PREDICTED: chromodomai (2025) 1055 84.8 7.9e-15 XP_016879557 (OMIM: 602120) PREDICTED: chromodomai (2036) 1055 84.8 7.9e-15 XP_016879555 (OMIM: 602120) PREDICTED: chromodomai (2036) 1055 84.8 7.9e-15 XP_016879556 (OMIM: 602120) PREDICTED: chromodomai (2045) 1055 84.8 7.9e-15 XP_016879554 (OMIM: 602120) PREDICTED: chromodomai (2047) 1055 84.8 7.9e-15 XP_016879559 (OMIM: 602120) PREDICTED: chromodomai (2050) 1055 84.8 7.9e-15 XP_016879553 (OMIM: 602120) PREDICTED: chromodomai (2055) 1055 84.8 8e-15 XP_016879552 (OMIM: 602120) PREDICTED: chromodomai (2056) 1055 84.8 8e-15 NP_001005271 (OMIM: 602120) chromodomain-helicase- (2059) 1055 84.8 8e-15 XP_005256486 (OMIM: 602120) PREDICTED: chromodomai (2060) 1055 84.8 8e-15 XP_005256485 (OMIM: 602120) PREDICTED: chromodomai (2080) 1055 84.8 8e-15 XP_016879551 (OMIM: 602120) PREDICTED: chromodomai (2105) 1055 84.8 8.1e-15 XP_016879550 (OMIM: 602120) PREDICTED: chromodomai (2109) 1055 84.8 8.1e-15 XP_006721487 (OMIM: 602120) PREDICTED: chromodomai (2111) 1055 84.8 8.1e-15 >>NP_620614 (OMIM: 600014,601358) probable global transc (1572 aa) initn: 10527 init1: 10527 opt: 10527 Z-score: 3693.2 bits: 696.2 E(85289): 5.7e-199 Smith-Waterman score: 10527; 100.0% identity (100.0% similar) in 1572 aa overlap (1-1572:1-1572) 10 20 30 40 50 60 pF1KE0 MSTPTDPGAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 MSTPTDPGAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPTM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPPHPGMGPPQSPMDQHSQGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPPHPGMGPPQSPMDQHSQGY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQAMSQPNRGPSPFSPVQLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 MSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQAMSQPNRGPSPFSPVQLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 QLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQQQQQQQQQQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 QLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQQQQQQQQQQPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 QQPPQPQTQQQQQPALVNYNRPSGPGPELSGPSTPQKLPVPAPGGRPSPAPPAAAQPPAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 QQPPQPQTQQQQQPALVNYNRPSGPGPELSGPSTPQKLPVPAPGGRPSPAPPAAAQPPAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 AVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 AVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 LENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 LENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 QTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 QTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 ATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 ATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 TNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDESSQMSDLPVKVTHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 TNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDESSQMSDLPVKVTHT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE0 ETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEEESSRQETEEKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 ETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEEESSRQETEEKI 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE0 LLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 LLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLI 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE0 NGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 NGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIV 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE0 PLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHIL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE0 AKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 AKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE0 TIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 TIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPE 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE0 KVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 KVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPY 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE0 MFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 MFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMT 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE0 IMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 IMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADT 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE0 VVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 VVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQ 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE0 AGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 AGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDR 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE0 RREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 RREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDAL 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE0 TEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPAKEDVEKAKKRRGRPPAEKLSPNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 TEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPAKEDVEKAKKRRGRPPAEKLSPNP 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE0 PKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRN 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KE0 HKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEDESNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 HKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEDESNE 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KE0 EEEEEDEEESESEAKSVKVKIKLNKKDDKGRDKGKGKKRPNRGKAKPVVSDFDSDEEQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 EEEEEDEEESESEAKSVKVKIKLNKKDDKGRDKGKGKKRPNRGKAKPVVSDFDSDEEQDE 1510 1520 1530 1540 1550 1560 1570 pF1KE0 REQSEGSGTDDE :::::::::::: NP_620 REQSEGSGTDDE 1570 >>NP_003061 (OMIM: 600014,601358) probable global transc (1590 aa) initn: 9415 init1: 9415 opt: 9415 Z-score: 3305.2 bits: 624.4 E(85289): 2.3e-177 Smith-Waterman score: 10481; 98.9% identity (98.9% similar) in 1590 aa overlap (1-1572:1-1590) 10 20 30 40 50 60 pF1KE0 MSTPTDPGAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MSTPTDPGAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPTM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPPHPGMGPPQSPMDQHSQGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPPHPGMGPPQSPMDQHSQGY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQAMSQPNRGPSPFSPVQLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQAMSQPNRGPSPFSPVQLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 QLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQQQQQQQQQQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQQQQQQQQQQPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 QQPPQPQTQQQQQPALVNYNRPSGPGPELSGPSTPQKLPVPAPGGRPSPAPPAAAQPPAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QQPPQPQTQQQQQPALVNYNRPSGPGPELSGPSTPQKLPVPAPGGRPSPAPPAAAQPPAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 AVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 LENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 QTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 ATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 TNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDESSQMSDLPVKVTHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDESSQMSDLPVKVTHT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE0 ETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEEESSRQETEEKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEEESSRQETEEKI 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE0 LLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLI 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE0 NGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIV 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE0 PLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHIL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE0 AKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE0 TIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPE 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE0 KVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPY 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE0 MFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMT 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE0 IMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADT 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE0 VVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQ 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE0 AGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDR 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE0 RREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDAL 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE0 TEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPAKEDVEKAKKRRGRPPAEKLSPNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPAKEDVEKAKKRRGRPPAEKLSPNP 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 pF1KE0 PKLTKQMNAIIDTVINYKD------------------SSGRQLSEVFIQLPSRKELPEYY ::::::::::::::::::: ::::::::::::::::::::::: NP_003 PKLTKQMNAIIDTVINYKDRCNVEKVPSNSQLEIEGNSSGRQLSEVFIQLPSRKELPEYY 1390 1400 1410 1420 1430 1440 1430 1440 1450 1460 1470 1480 pF1KE0 ELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFK 1450 1460 1470 1480 1490 1500 1490 1500 1510 1520 1530 1540 pF1KE0 SARQKIAKEEESEDESNEEEEEEDEEESESEAKSVKVKIKLNKKDDKGRDKGKGKKRPNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SARQKIAKEEESEDESNEEEEEEDEEESESEAKSVKVKIKLNKKDDKGRDKGKGKKRPNR 1510 1520 1530 1540 1550 1560 1550 1560 1570 pF1KE0 GKAKPVVSDFDSDEEQDEREQSEGSGTDDE :::::::::::::::::::::::::::::: NP_003 GKAKPVVSDFDSDEEQDEREQSEGSGTDDE 1570 1580 1590 >>NP_001276325 (OMIM: 600014,601358) probable global tra (1590 aa) initn: 9415 init1: 9415 opt: 9415 Z-score: 3305.2 bits: 624.4 E(85289): 2.3e-177 Smith-Waterman score: 10481; 98.9% identity (98.9% similar) in 1590 aa overlap (1-1572:1-1590) 10 20 30 40 50 60 pF1KE0 MSTPTDPGAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSTPTDPGAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPTM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPPHPGMGPPQSPMDQHSQGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPPHPGMGPPQSPMDQHSQGY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQAMSQPNRGPSPFSPVQLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQAMSQPNRGPSPFSPVQLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 QLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQQQQQQQQQQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQQQQQQQQQQPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 QQPPQPQTQQQQQPALVNYNRPSGPGPELSGPSTPQKLPVPAPGGRPSPAPPAAAQPPAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQPPQPQTQQQQQPALVNYNRPSGPGPELSGPSTPQKLPVPAPGGRPSPAPPAAAQPPAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 AVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 LENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 QTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 ATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 TNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDESSQMSDLPVKVTHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDESSQMSDLPVKVTHT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE0 ETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEEESSRQETEEKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEEESSRQETEEKI 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE0 LLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLI 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE0 NGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIV 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE0 PLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHIL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE0 AKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE0 TIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPE 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE0 KVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPY 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE0 MFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMT 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE0 IMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADT 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE0 VVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQ 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE0 AGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDR 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE0 RREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDAL 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE0 TEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPAKEDVEKAKKRRGRPPAEKLSPNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPAKEDVEKAKKRRGRPPAEKLSPNP 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 pF1KE0 PKLTKQMNAIIDTVINYKD------------------SSGRQLSEVFIQLPSRKELPEYY ::::::::::::::::::: ::::::::::::::::::::::: NP_001 PKLTKQMNAIIDTVINYKDRCNVEKVPSNSQLEIEGNSSGRQLSEVFIQLPSRKELPEYY 1390 1400 1410 1420 1430 1440 1430 1440 1450 1460 1470 1480 pF1KE0 ELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFK 1450 1460 1470 1480 1490 1500 1490 1500 1510 1520 1530 1540 pF1KE0 SARQKIAKEEESEDESNEEEEEEDEEESESEAKSVKVKIKLNKKDDKGRDKGKGKKRPNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SARQKIAKEEESEDESNEEEEEEDEEESESEAKSVKVKIKLNKKDDKGRDKGKGKKRPNR 1510 1520 1530 1540 1550 1560 1550 1560 1570 pF1KE0 GKAKPVVSDFDSDEEQDEREQSEGSGTDDE :::::::::::::::::::::::::::::: NP_001 GKAKPVVSDFDSDEEQDEREQSEGSGTDDE 1570 1580 1590 >>XP_016882657 (OMIM: 603254,613325,614609) PREDICTED: t (1613 aa) initn: 7066 init1: 4040 opt: 6400 Z-score: 2253.3 bits: 429.8 E(85289): 9.1e-119 Smith-Waterman score: 8141; 76.6% identity (89.0% similar) in 1624 aa overlap (1-1570:1-1613) 10 20 30 40 50 pF1KE0 MSTPTDP-GAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPT :::: : :. :.:::::::::::: .::::::: ::::.::::::::::::..::.:: XP_016 MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGP--SPGSAHSMMGPSPGPPSAGHPIPT 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 MGSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPP-HPGMGPPQSPMDQHSQ .: .::..:::::::....:.::. .: . ..::: ::: : ::::: :::::::: XP_016 QGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GYMSPHPSPLGAPEHVSSPMSGGGPTP-PQMPPSQPGALIPG-DPQAMSQPNRGPSPFSP :: :::::. ::.:::. ..::. ::: . :: . : ::::..: ::::.::. XP_016 GY----PSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQ 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 VQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQ---------- :::::::::.::::::::::::. ::.:::::: .::.:::. . XP_016 NQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGP 180 190 200 210 220 230 230 240 250 260 270 pF1KE0 -----------QQQQQQQQQQQQPQQQPPQPQT----QQQQQPALVNYNRPSGPGPELSG . .. . . :.. :: :. . : :. : :: . .. XP_016 GPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAA 240 250 260 270 280 290 280 290 300 310 320 pF1KE0 P-STPQKLPVPAPGGRPSPAPPAAAQPPAAA-VPGPSVPQPA-PGQPSPVLQLQQKQSRI : :::::: : : :::::::::. ::::. : :.. .:. :.::.:.. :.:::::: XP_016 PTSTPQKLIPPQPTGRPSPAPPAV--PPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRI 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE0 SPIQKPQGLDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNF .:::::.::::::::::::::::::::::::::::::::: :::::::.:::::::::: XP_016 TPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNF 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE0 QRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKH :::::::::.::::::.::::::.:::::::::.:::::.:::::::::::::::::::: XP_016 QRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKH 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE0 QEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMA :::::::::::::::::::::.::::::.:::::.:::::::::::.::::::::::::: XP_016 QEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMA 480 490 500 510 520 530 510 520 530 540 550 560 pF1KE0 EDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEE :::::::::::::::.:::::::::::::::::.:: .:: ::.::::::....:: : XP_016 EDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKK--AE 540 550 560 570 580 590 570 580 590 600 610 620 pF1KE0 NAEGGESALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYE :::: :.::::::.::.:::::::::: :.:.::.: : .::::.::.:::::::::: XP_016 NAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYE 600 610 620 630 640 650 630 640 650 660 670 680 pF1KE0 VAPRSDSEESDSDYEEEDEEEESSRQET-------EEKILLDPNSEEVSEKDAKQIIETA :::::::::: :. :::.::::. . :.: . ::.:..::: ::..:::.: XP_016 VAPRSDSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENA 660 670 680 690 700 710 690 700 710 720 730 740 pF1KE0 KQDVDDEYSM-QYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYN ::::::::.. : ::: ::::.::::..:::.:::::..::.::.::..::::.::::: XP_016 KQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYN 720 730 740 750 760 770 750 760 770 780 790 800 pF1KE0 NNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVV :::::::::::::::::::::::::::::::.:::.::::::::::::.::::::::::: XP_016 NNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVV 780 790 800 810 820 830 810 820 830 840 850 860 pF1KE0 KISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHH :.::::.:: ::..:::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHH 840 850 860 870 880 890 870 880 890 900 910 920 pF1KE0 CKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: XP_016 CKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT 900 910 920 930 940 950 930 940 950 960 970 980 pF1KE0 GERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRH ::.::::::::::::::::::::::::::::::::.::::::::::::::::::..:::: XP_016 GEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRH 960 970 980 990 1000 1010 990 1000 1010 1020 1030 1040 pF1KE0 MQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVI :::::.:::::::::::::::.:::::::::::::::::::::::::::.::::...:.. XP_016 MQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIV 1020 1030 1040 1050 1060 1070 1050 1060 1070 1080 1090 1100 pF1KE0 NGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTT .: .:::::::::::::::::::::::.:::::::::::::::::::.:.: :::::::: XP_016 QGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTT 1080 1090 1100 1110 1120 1130 1110 1120 1130 1140 1150 1160 pF1KE0 KSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRA :.:::. ::: ::::::.::::::::::::::::::.::::.:::::::::::::::::: XP_016 KAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRA 1140 1150 1160 1170 1180 1190 1170 1180 1190 1200 1210 1220 pF1KE0 HRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAI 1200 1210 1220 1230 1240 1250 1230 1240 1250 1260 1270 1280 pF1KE0 LEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDEL :::::..:::::::::::.::::::.:::::::::::.:::::.:::::::::::::::: XP_016 LEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDEL 1260 1270 1280 1290 1300 1310 1290 1300 1310 1320 1330 1340 pF1KE0 PSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTEKQWLRAIEDGNLEEMEEE ::::::::::::::::::::::.::::::.:..:::::.:::::::.:::.:.:::.::: XP_016 PSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEE 1320 1330 1340 1350 1360 1370 1350 1360 1370 1380 pF1KE0 VRLKKRKRRRNVDKD-----PA-------KEDVEKAKKRRGRPPAEKLSPNPPKLTKQMN :: :: .:.:. :.: :. :.: : .:.::::::::::::::.:::.:. XP_016 VRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMK 1380 1390 1400 1410 1420 1430 1390 1400 1410 1420 1430 1440 pF1KE0 AIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGD :.:.::.::::::::::::::::::::::::::::::::::::::::::::::::::.: XP_016 KIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLND 1440 1450 1460 1470 1480 1490 1450 1460 1470 1480 1490 1500 pF1KE0 LEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEDESNEEEEEEDEE :::::::::.:::::::::: :::::::::::: :.:::: ::..:: : .::::: .:: XP_016 LEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEE 1500 1510 1520 1530 1540 1550 1510 1520 1530 1540 1550 1560 pF1KE0 ESESEAKSVKVKIKLNKKDDKGRDKGKG-KKRPNRG-KAKPVVSDFDSDEEQDEREQSEG ::::..::::::::..:. :..:. :: ..::.:: .::::::: ::.:::.: ... : XP_016 GSESESRSVKVKIKLGRKE-KAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSG 1560 1570 1580 1590 1600 1570 pF1KE0 SGTDDE : : XP_016 SEED 1610 >>NP_001122320 (OMIM: 603254,613325,614609) transcriptio (1613 aa) initn: 7066 init1: 4040 opt: 6400 Z-score: 2253.3 bits: 429.8 E(85289): 9.1e-119 Smith-Waterman score: 8141; 76.6% identity (89.0% similar) in 1624 aa overlap (1-1570:1-1613) 10 20 30 40 50 pF1KE0 MSTPTDP-GAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPT :::: : :. :.:::::::::::: .::::::: ::::.::::::::::::..::.:: NP_001 MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGP--SPGSAHSMMGPSPGPPSAGHPIPT 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 MGSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPP-HPGMGPPQSPMDQHSQ .: .::..:::::::....:.::. .: . ..::: ::: : ::::: :::::::: NP_001 QGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GYMSPHPSPLGAPEHVSSPMSGGGPTP-PQMPPSQPGALIPG-DPQAMSQPNRGPSPFSP :: :::::. ::.:::. ..::. ::: . :: . : ::::..: ::::.::. NP_001 GY----PSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQ 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 VQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQ---------- :::::::::.::::::::::::. ::.:::::: .::.:::. . NP_001 NQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGP 180 190 200 210 220 230 230 240 250 260 270 pF1KE0 -----------QQQQQQQQQQQQPQQQPPQPQT----QQQQQPALVNYNRPSGPGPELSG . .. . . :.. :: :. . : :. : :: . .. NP_001 GPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAA 240 250 260 270 280 290 280 290 300 310 320 pF1KE0 P-STPQKLPVPAPGGRPSPAPPAAAQPPAAA-VPGPSVPQPA-PGQPSPVLQLQQKQSRI : :::::: : : :::::::::. ::::. : :.. .:. :.::.:.. :.:::::: NP_001 PTSTPQKLIPPQPTGRPSPAPPAV--PPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRI 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE0 SPIQKPQGLDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNF .:::::.::::::::::::::::::::::::::::::::: :::::::.:::::::::: NP_001 TPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNF 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE0 QRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKH :::::::::.::::::.::::::.:::::::::.:::::.:::::::::::::::::::: NP_001 QRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKH 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE0 QEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMA :::::::::::::::::::::.::::::.:::::.:::::::::::.::::::::::::: NP_001 QEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMA 480 490 500 510 520 530 510 520 530 540 550 560 pF1KE0 EDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEE :::::::::::::::.:::::::::::::::::.:: .:: ::.::::::....:: : NP_001 EDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKK--AE 540 550 560 570 580 590 570 580 590 600 610 620 pF1KE0 NAEGGESALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYE :::: :.::::::.::.:::::::::: :.:.::.: : .::::.::.:::::::::: NP_001 NAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYE 600 610 620 630 640 650 630 640 650 660 670 680 pF1KE0 VAPRSDSEESDSDYEEEDEEEESSRQET-------EEKILLDPNSEEVSEKDAKQIIETA :::::::::: :. :::.::::. . :.: . ::.:..::: ::..:::.: NP_001 VAPRSDSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENA 660 670 680 690 700 710 690 700 710 720 730 740 pF1KE0 KQDVDDEYSM-QYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYN ::::::::.. : ::: ::::.::::..:::.:::::..::.::.::..::::.::::: NP_001 KQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYN 720 730 740 750 760 770 750 760 770 780 790 800 pF1KE0 NNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVV :::::::::::::::::::::::::::::::.:::.::::::::::::.::::::::::: NP_001 NNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVV 780 790 800 810 820 830 810 820 830 840 850 860 pF1KE0 KISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHH :.::::.:: ::..:::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHH 840 850 860 870 880 890 870 880 890 900 910 920 pF1KE0 CKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: NP_001 CKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT 900 910 920 930 940 950 930 940 950 960 970 980 pF1KE0 GERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRH ::.::::::::::::::::::::::::::::::::.::::::::::::::::::..:::: NP_001 GEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRH 960 970 980 990 1000 1010 990 1000 1010 1020 1030 1040 pF1KE0 MQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVI :::::.:::::::::::::::.:::::::::::::::::::::::::::.::::...:.. NP_001 MQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIV 1020 1030 1040 1050 1060 1070 1050 1060 1070 1080 1090 1100 pF1KE0 NGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTT .: .:::::::::::::::::::::::.:::::::::::::::::::.:.: :::::::: NP_001 QGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTT 1080 1090 1100 1110 1120 1130 1110 1120 1130 1140 1150 1160 pF1KE0 KSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRA :.:::. ::: ::::::.::::::::::::::::::.::::.:::::::::::::::::: NP_001 KAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRA 1140 1150 1160 1170 1180 1190 1170 1180 1190 1200 1210 1220 pF1KE0 HRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAI 1200 1210 1220 1230 1240 1250 1230 1240 1250 1260 1270 1280 pF1KE0 LEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDEL :::::..:::::::::::.::::::.:::::::::::.:::::.:::::::::::::::: NP_001 LEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDEL 1260 1270 1280 1290 1300 1310 1290 1300 1310 1320 1330 1340 pF1KE0 PSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTEKQWLRAIEDGNLEEMEEE ::::::::::::::::::::::.::::::.:..:::::.:::::::.:::.:.:::.::: NP_001 PSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEE 1320 1330 1340 1350 1360 1370 1350 1360 1370 1380 pF1KE0 VRLKKRKRRRNVDKD-----PA-------KEDVEKAKKRRGRPPAEKLSPNPPKLTKQMN :: :: .:.:. :.: :. :.: : .:.::::::::::::::.:::.:. NP_001 VRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMK 1380 1390 1400 1410 1420 1430 1390 1400 1410 1420 1430 1440 pF1KE0 AIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGD :.:.::.::::::::::::::::::::::::::::::::::::::::::::::::::.: NP_001 KIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLND 1440 1450 1460 1470 1480 1490 1450 1460 1470 1480 1490 1500 pF1KE0 LEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEDESNEEEEEEDEE :::::::::.:::::::::: :::::::::::: :.:::: ::..:: : .::::: .:: NP_001 LEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEE 1500 1510 1520 1530 1540 1550 1510 1520 1530 1540 1550 1560 pF1KE0 ESESEAKSVKVKIKLNKKDDKGRDKGKG-KKRPNRG-KAKPVVSDFDSDEEQDEREQSEG ::::..::::::::..:. :..:. :: ..::.:: .::::::: ::.:::.: ... : NP_001 GSESESRSVKVKIKLGRKE-KAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSG 1560 1570 1580 1590 1600 1570 pF1KE0 SGTDDE : : NP_001 SEED 1610 >>XP_016882656 (OMIM: 603254,613325,614609) PREDICTED: t (1614 aa) initn: 6900 init1: 4045 opt: 6364 Z-score: 2240.7 bits: 427.5 E(85289): 4.5e-118 Smith-Waterman score: 8129; 76.6% identity (88.9% similar) in 1625 aa overlap (1-1570:1-1614) 10 20 30 40 50 pF1KE0 MSTPTDP-GAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPT :::: : :. :.:::::::::::: .::::::: ::::.::::::::::::..::.:: XP_016 MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGP--SPGSAHSMMGPSPGPPSAGHPIPT 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 MGSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPP-HPGMGPPQSPMDQHSQ .: .::..:::::::....:.::. .: . ..::: ::: : ::::: :::::::: XP_016 QGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GYMSPHPSPLGAPEHVSSPMSGGGPTP-PQMPPSQPGALIPG-DPQAMSQPNRGPSPFSP :: :::::. ::.:::. ..::. ::: . :: . : ::::..: ::::.::. XP_016 GY----PSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQ 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 VQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQ---------- :::::::::.::::::::::::. ::.:::::: .::.:::. . XP_016 NQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGP 180 190 200 210 220 230 230 240 250 260 270 pF1KE0 -----------QQQQQQQQQQQQPQQQPPQPQT----QQQQQPALVNYNRPSGPGPELSG . .. . . :.. :: :. . : :. : :: . .. XP_016 GPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAA 240 250 260 270 280 290 280 290 300 310 320 pF1KE0 P-STPQKLPVPAPGGRPSPAPPAAAQPPAAA-VPGPSVPQPA-PGQPSPVLQLQQKQSRI : :::::: : : :::::::::. ::::. : :.. .:. :.::.:.. :.:::::: XP_016 PTSTPQKLIPPQPTGRPSPAPPAV--PPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRI 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE0 SPIQKPQGLDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNF .:::::.::::::::::::::::::::::::::::::::: :::::::.:::::::::: XP_016 TPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNF 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE0 QRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKH :::::::::.::::::.::::::.:::::::::.:::::.:::::::::::::::::::: XP_016 QRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKH 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE0 QEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMA :::::::::::::::::::::.::::::.:::::.:::::::::::.::::::::::::: XP_016 QEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMA 480 490 500 510 520 530 510 520 530 540 550 560 pF1KE0 EDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEE :::::::::::::::.:::::::::::::::::.:: .:: ::.::::::....:: : XP_016 EDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKK--AE 540 550 560 570 580 590 570 580 590 600 610 620 pF1KE0 NAEGGESALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYE :::: :.::::::.::.:::::::::: :.:.::.: : .::::.::.:::::::::: XP_016 NAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYE 600 610 620 630 640 650 630 640 650 660 670 680 pF1KE0 VAPRSDSEESDSDYEEEDEEEESSRQET-------EEKILLDPNSEEVSEKDAKQIIETA :::::::::: :. :::.::::. . :.: . ::.:..::: ::..:::.: XP_016 VAPRSDSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENA 660 670 680 690 700 710 690 700 710 720 730 740 pF1KE0 KQDVDDEYSM-QYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYN ::::::::.. : ::: ::::.::::..:::.:::::..::.::.::..::::.::::: XP_016 KQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYN 720 730 740 750 760 770 750 760 770 780 790 800 pF1KE0 NNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVV :::::::::::::::::::::::::::::::.:::.::::::::::::.::::::::::: XP_016 NNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVV 780 790 800 810 820 830 810 820 830 840 850 860 pF1KE0 KISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHH :.::::.:: ::..:::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHH 840 850 860 870 880 890 870 880 890 900 910 920 pF1KE0 CKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: XP_016 CKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT 900 910 920 930 940 950 930 940 950 960 970 980 pF1KE0 GERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRH ::.::::::::::::::::::::::::::::::::.::::::::::::::::::..:::: XP_016 GEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRH 960 970 980 990 1000 1010 990 1000 1010 1020 1030 1040 pF1KE0 MQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVI :::::.:::::::::::::::.:::::::::::::::::::::::::::.::::...:.. XP_016 MQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIV 1020 1030 1040 1050 1060 1070 1050 1060 1070 1080 1090 1100 pF1KE0 NGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTT .: .:::::::::::::::::::::::.:::::::::::::::::::.:.: :::::::: XP_016 QGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTT 1080 1090 1100 1110 1120 1130 1110 1120 1130 1140 1150 1160 pF1KE0 KSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRA :.:::. ::: ::::::.::::::::::::::::::.::::.:::::::::::::::::: XP_016 KAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRA 1140 1150 1160 1170 1180 1190 1170 1180 1190 1200 1210 1220 pF1KE0 HRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAI 1200 1210 1220 1230 1240 1250 1230 1240 1250 1260 1270 1280 pF1KE0 LEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDEL :::::..:::::::::::.::::::.:::::::::::.:::::.:::::::::::::::: XP_016 LEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDEL 1260 1270 1280 1290 1300 1310 1290 1300 1310 1320 1330 1340 pF1KE0 PSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTEKQWLRAIEDGNLEEMEEE ::::::::::::::::::::::.::::::.:..:::::.:::::::.:::.:.:::.::: XP_016 PSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEE 1320 1330 1340 1350 1360 1370 1350 1360 1370 1380 pF1KE0 VRLKKRKRRRNVDKD-----PA-------KEDVEKAKKRRGRPPAEKLSPNPPKLTKQMN :: :: .:.:. :.: :. :.: : .:.::::::::::::::.:::.:. XP_016 VRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMK 1380 1390 1400 1410 1420 1430 1390 1400 1410 1420 1430 1440 pF1KE0 AIIDTVINYKDSS-GRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLG :.:.::.::::: :::::::::::::::::::::::::::::::::::::::::::::. XP_016 KIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLN 1440 1450 1460 1470 1480 1490 1450 1460 1470 1480 1490 1500 pF1KE0 DLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEDESNEEEEEEDE ::::::::::.:::::::::: :::::::::::: :.:::: ::..:: : .::::: .: XP_016 DLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEE 1500 1510 1520 1530 1540 1550 1510 1520 1530 1540 1550 1560 pF1KE0 EESESEAKSVKVKIKLNKKDDKGRDKGKG-KKRPNRG-KAKPVVSDFDSDEEQDEREQSE : ::::..::::::::..:. :..:. :: ..::.:: .::::::: ::.:::.: ... XP_016 EGSESESRSVKVKIKLGRKE-KAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGS 1560 1570 1580 1590 1600 1570 pF1KE0 GSGTDDE :: : XP_016 GSEED 1610 >>NP_001122319 (OMIM: 603254,613325,614609) transcriptio (1614 aa) initn: 6900 init1: 4045 opt: 6364 Z-score: 2240.7 bits: 427.5 E(85289): 4.5e-118 Smith-Waterman score: 8129; 76.6% identity (88.9% similar) in 1625 aa overlap (1-1570:1-1614) 10 20 30 40 50 pF1KE0 MSTPTDP-GAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPT :::: : :. :.:::::::::::: .::::::: ::::.::::::::::::..::.:: NP_001 MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGP--SPGSAHSMMGPSPGPPSAGHPIPT 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 MGSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPP-HPGMGPPQSPMDQHSQ .: .::..:::::::....:.::. .: . ..::: ::: : ::::: :::::::: NP_001 QGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GYMSPHPSPLGAPEHVSSPMSGGGPTP-PQMPPSQPGALIPG-DPQAMSQPNRGPSPFSP :: :::::. ::.:::. ..::. ::: . :: . : ::::..: ::::.::. NP_001 GY----PSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQ 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 VQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQ---------- :::::::::.::::::::::::. ::.:::::: .::.:::. . NP_001 NQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGP 180 190 200 210 220 230 230 240 250 260 270 pF1KE0 -----------QQQQQQQQQQQQPQQQPPQPQT----QQQQQPALVNYNRPSGPGPELSG . .. . . :.. :: :. . : :. : :: . .. NP_001 GPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAA 240 250 260 270 280 290 280 290 300 310 320 pF1KE0 P-STPQKLPVPAPGGRPSPAPPAAAQPPAAA-VPGPSVPQPA-PGQPSPVLQLQQKQSRI : :::::: : : :::::::::. ::::. : :.. .:. :.::.:.. :.:::::: NP_001 PTSTPQKLIPPQPTGRPSPAPPAV--PPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRI 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE0 SPIQKPQGLDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNF .:::::.::::::::::::::::::::::::::::::::: :::::::.:::::::::: NP_001 TPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNF 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE0 QRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKH :::::::::.::::::.::::::.:::::::::.:::::.:::::::::::::::::::: NP_001 QRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKH 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE0 QEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMA :::::::::::::::::::::.::::::.:::::.:::::::::::.::::::::::::: NP_001 QEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMA 480 490 500 510 520 530 510 520 530 540 550 560 pF1KE0 EDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEE :::::::::::::::.:::::::::::::::::.:: .:: ::.::::::....:: : NP_001 EDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKK--AE 540 550 560 570 580 590 570 580 590 600 610 620 pF1KE0 NAEGGESALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYE :::: :.::::::.::.:::::::::: :.:.::.: : .::::.::.:::::::::: NP_001 NAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYE 600 610 620 630 640 650 630 640 650 660 670 680 pF1KE0 VAPRSDSEESDSDYEEEDEEEESSRQET-------EEKILLDPNSEEVSEKDAKQIIETA :::::::::: :. :::.::::. . :.: . ::.:..::: ::..:::.: NP_001 VAPRSDSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENA 660 670 680 690 700 710 690 700 710 720 730 740 pF1KE0 KQDVDDEYSM-QYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYN ::::::::.. : ::: ::::.::::..:::.:::::..::.::.::..::::.::::: NP_001 KQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYN 720 730 740 750 760 770 750 760 770 780 790 800 pF1KE0 NNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVV :::::::::::::::::::::::::::::::.:::.::::::::::::.::::::::::: NP_001 NNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVV 780 790 800 810 820 830 810 820 830 840 850 860 pF1KE0 KISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHH :.::::.:: ::..:::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHH 840 850 860 870 880 890 870 880 890 900 910 920 pF1KE0 CKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: NP_001 CKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT 900 910 920 930 940 950 930 940 950 960 970 980 pF1KE0 GERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRH ::.::::::::::::::::::::::::::::::::.::::::::::::::::::..:::: NP_001 GEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRH 960 970 980 990 1000 1010 990 1000 1010 1020 1030 1040 pF1KE0 MQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVI :::::.:::::::::::::::.:::::::::::::::::::::::::::.::::...:.. NP_001 MQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIV 1020 1030 1040 1050 1060 1070 1050 1060 1070 1080 1090 1100 pF1KE0 NGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTT .: .:::::::::::::::::::::::.:::::::::::::::::::.:.: :::::::: NP_001 QGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTT 1080 1090 1100 1110 1120 1130 1110 1120 1130 1140 1150 1160 pF1KE0 KSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRA :.:::. ::: ::::::.::::::::::::::::::.::::.:::::::::::::::::: NP_001 KAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRA 1140 1150 1160 1170 1180 1190 1170 1180 1190 1200 1210 1220 pF1KE0 HRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAI 1200 1210 1220 1230 1240 1250 1230 1240 1250 1260 1270 1280 pF1KE0 LEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDEL :::::..:::::::::::.::::::.:::::::::::.:::::.:::::::::::::::: NP_001 LEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDEL 1260 1270 1280 1290 1300 1310 1290 1300 1310 1320 1330 1340 pF1KE0 PSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTEKQWLRAIEDGNLEEMEEE ::::::::::::::::::::::.::::::.:..:::::.:::::::.:::.:.:::.::: NP_001 PSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEE 1320 1330 1340 1350 1360 1370 1350 1360 1370 1380 pF1KE0 VRLKKRKRRRNVDKD-----PA-------KEDVEKAKKRRGRPPAEKLSPNPPKLTKQMN :: :: .:.:. :.: :. :.: : .:.::::::::::::::.:::.:. NP_001 VRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMK 1380 1390 1400 1410 1420 1430 1390 1400 1410 1420 1430 1440 pF1KE0 AIIDTVINYKDSS-GRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLG :.:.::.::::: :::::::::::::::::::::::::::::::::::::::::::::. NP_001 KIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLN 1440 1450 1460 1470 1480 1490 1450 1460 1470 1480 1490 1500 pF1KE0 DLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEDESNEEEEEEDE ::::::::::.:::::::::: :::::::::::: :.:::: ::..:: : .::::: .: NP_001 DLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEE 1500 1510 1520 1530 1540 1550 1510 1520 1530 1540 1550 1560 pF1KE0 EESESEAKSVKVKIKLNKKDDKGRDKGKG-KKRPNRG-KAKPVVSDFDSDEEQDEREQSE : ::::..::::::::..:. :..:. :: ..::.:: .::::::: ::.:::.: ... NP_001 EGSESESRSVKVKIKLGRKE-KAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGS 1560 1570 1580 1590 1600 1570 pF1KE0 GSGTDDE :: : NP_001 GSEED 1610 >>XP_016882655 (OMIM: 603254,613325,614609) PREDICTED: t (1616 aa) initn: 6957 init1: 3931 opt: 6320 Z-score: 2225.3 bits: 424.6 E(85289): 3.3e-117 Smith-Waterman score: 8125; 76.5% identity (88.8% similar) in 1627 aa overlap (1-1570:1-1616) 10 20 30 40 50 pF1KE0 MSTPTDP-GAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPT :::: : :. :.:::::::::::: .::::::: ::::.::::::::::::..::.:: XP_016 MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGP--SPGSAHSMMGPSPGPPSAGHPIPT 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 MGSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPP-HPGMGPPQSPMDQHSQ .: .::..:::::::....:.::. .: . ..::: ::: : ::::: :::::::: XP_016 QGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GYMSPHPSPLGAPEHVSSPMSGGGPTP-PQMPPSQPGALIPG-DPQAMSQPNRGPSPFSP :: :::::. ::.:::. ..::. ::: . :: . : ::::..: ::::.::. XP_016 GY----PSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQ 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 VQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQ---------- :::::::::.::::::::::::. ::.:::::: .::.:::. . XP_016 NQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGP 180 190 200 210 220 230 230 240 250 260 270 pF1KE0 -----------QQQQQQQQQQQQPQQQPPQPQT----QQQQQPALVNYNRPSGPGPELSG . .. . . :.. :: :. . : :. : :: . .. XP_016 GPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAA 240 250 260 270 280 290 280 290 300 310 320 pF1KE0 P-STPQKLPVPAPGGRPSPAPPAAAQPPAAA-VPGPSVPQPA-PGQPSPVLQLQQKQSRI : :::::: : : :::::::::. ::::. : :.. .:. :.::.:.. :.:::::: XP_016 PTSTPQKLIPPQPTGRPSPAPPAV--PPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRI 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE0 SPIQKPQGLDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNF .:::::.::::::::::::::::::::::::::::::::: :::::::.:::::::::: XP_016 TPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNF 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE0 QRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKH :::::::::.::::::.::::::.:::::::::.:::::.:::::::::::::::::::: XP_016 QRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKH 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE0 QEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMA :::::::::::::::::::::.::::::.:::::.:::::::::::.::::::::::::: XP_016 QEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMA 480 490 500 510 520 530 510 520 530 540 550 560 pF1KE0 EDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEE :::::::::::::::.:::::::::::::::::.:: .:: ::.::::::....:: : XP_016 EDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKK--AE 540 550 560 570 580 590 570 580 590 600 610 620 pF1KE0 NAEGGESALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYE :::: :.::::::.::.:::::::::: :.:.::.: : .::::.::.:::::::::: XP_016 NAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYE 600 610 620 630 640 650 630 640 650 660 670 680 pF1KE0 VAPRSDSEESDSDYEEEDEEEESSRQET-------EEKILLDPNSEEVSEKDAKQIIETA :::::::::: :. :::.::::. . :.: . ::.:..::: ::..:::.: XP_016 VAPRSDSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENA 660 670 680 690 700 710 690 700 710 720 730 740 pF1KE0 KQDVDDEYSM-QYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYN ::::::::.. : ::: ::::.::::..:::.:::::..::.::.::..::::.::::: XP_016 KQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYN 720 730 740 750 760 770 750 760 770 780 790 800 pF1KE0 NNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVV :::::::::::::::::::::::::::::::.:::.::::::::::::.::::::::::: XP_016 NNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVV 780 790 800 810 820 830 810 820 830 840 850 860 pF1KE0 KISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHH :.::::.:: ::..:::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHH 840 850 860 870 880 890 870 880 890 900 910 920 pF1KE0 CKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: XP_016 CKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT 900 910 920 930 940 950 930 940 950 960 970 980 pF1KE0 GERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRH ::.::::::::::::::::::::::::::::::::.::::::::::::::::::..:::: XP_016 GEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRH 960 970 980 990 1000 1010 990 1000 1010 1020 1030 1040 pF1KE0 MQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVI :::::.:::::::::::::::.:::::::::::::::::::::::::::.::::...:.. XP_016 MQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIV 1020 1030 1040 1050 1060 1070 1050 1060 1070 1080 1090 1100 pF1KE0 NGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTT .: .:::::::::::::::::::::::.:::::::::::::::::::.:.: :::::::: XP_016 QGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTT 1080 1090 1100 1110 1120 1130 1110 1120 1130 1140 1150 1160 pF1KE0 KSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRA :.:::. ::: ::::::.::::::::::::::::::.::::.:::::::::::::::::: XP_016 KAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRA 1140 1150 1160 1170 1180 1190 1170 1180 1190 1200 1210 1220 pF1KE0 HRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAI 1200 1210 1220 1230 1240 1250 1230 1240 1250 1260 1270 1280 pF1KE0 LEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDEL :::::..:::::::::::.::::::.:::::::::::.:::::.:::::::::::::::: XP_016 LEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDEL 1260 1270 1280 1290 1300 1310 1290 1300 1310 1320 1330 pF1KE0 PSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTEKQWLR---AIEDGNLEEM ::::::::::::::::::::::.::::::.:..:::::.:::::::. :::.:.:::. XP_016 PSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKTLKAIEEGTLEEI 1320 1330 1340 1350 1360 1370 1340 1350 1360 1370 1380 pF1KE0 EEEVRLKKRKRRRNVDKD-----PA-------KEDVEKAKKRRGRPPAEKLSPNPPKLTK ::::: :: .:.:. :.: :. :.: : .:.::::::::::::::.::: XP_016 EEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTK 1380 1390 1400 1410 1420 1430 1390 1400 1410 1420 1430 1440 pF1KE0 QMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRS .:. :.:.::.::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRS 1440 1450 1460 1470 1480 1490 1450 1460 1470 1480 1490 1500 pF1KE0 LGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEDESNEEEEEE :.::::::::::.:::::::::: :::::::::::: :.:::: ::..:: : .::::: XP_016 LNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEG 1500 1510 1520 1530 1540 1550 1510 1520 1530 1540 1550 1560 pF1KE0 DEEESESEAKSVKVKIKLNKKDDKGRDKGKG-KKRPNRG-KAKPVVSDFDSDEEQDEREQ .:: ::::..::::::::..:. :..:. :: ..::.:: .::::::: ::.:::.: .. XP_016 EEEGSESESRSVKVKIKLGRKE-KAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRS 1560 1570 1580 1590 1600 1570 pF1KE0 SEGSGTDDE . :: : XP_016 GSGSEED 1610 >>NP_001122318 (OMIM: 603254,613325,614609) transcriptio (1616 aa) initn: 6957 init1: 3931 opt: 6320 Z-score: 2225.3 bits: 424.6 E(85289): 3.3e-117 Smith-Waterman score: 8125; 76.5% identity (88.8% similar) in 1627 aa overlap (1-1570:1-1616) 10 20 30 40 50 pF1KE0 MSTPTDP-GAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPT :::: : :. :.:::::::::::: .::::::: ::::.::::::::::::..::.:: NP_001 MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGP--SPGSAHSMMGPSPGPPSAGHPIPT 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 MGSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPP-HPGMGPPQSPMDQHSQ .: .::..:::::::....:.::. .: . ..::: ::: : ::::: :::::::: NP_001 QGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GYMSPHPSPLGAPEHVSSPMSGGGPTP-PQMPPSQPGALIPG-DPQAMSQPNRGPSPFSP :: :::::. ::.:::. ..::. ::: . :: . : ::::..: ::::.::. NP_001 GY----PSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQ 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 VQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQ---------- :::::::::.::::::::::::. ::.:::::: .::.:::. . NP_001 NQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGP 180 190 200 210 220 230 230 240 250 260 270 pF1KE0 -----------QQQQQQQQQQQQPQQQPPQPQT----QQQQQPALVNYNRPSGPGPELSG . .. . . :.. :: :. . : :. : :: . .. NP_001 GPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAA 240 250 260 270 280 290 280 290 300 310 320 pF1KE0 P-STPQKLPVPAPGGRPSPAPPAAAQPPAAA-VPGPSVPQPA-PGQPSPVLQLQQKQSRI : :::::: : : :::::::::. ::::. : :.. .:. :.::.:.. :.:::::: NP_001 PTSTPQKLIPPQPTGRPSPAPPAV--PPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRI 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE0 SPIQKPQGLDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNF .:::::.::::::::::::::::::::::::::::::::: :::::::.:::::::::: NP_001 TPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNF 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE0 QRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKH :::::::::.::::::.::::::.:::::::::.:::::.:::::::::::::::::::: NP_001 QRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKH 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE0 QEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMA :::::::::::::::::::::.::::::.:::::.:::::::::::.::::::::::::: NP_001 QEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMA 480 490 500 510 520 530 510 520 530 540 550 560 pF1KE0 EDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEE :::::::::::::::.:::::::::::::::::.:: .:: ::.::::::....:: : NP_001 EDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKK--AE 540 550 560 570 580 590 570 580 590 600 610 620 pF1KE0 NAEGGESALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYE :::: :.::::::.::.:::::::::: :.:.::.: : .::::.::.:::::::::: NP_001 NAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYE 600 610 620 630 640 650 630 640 650 660 670 680 pF1KE0 VAPRSDSEESDSDYEEEDEEEESSRQET-------EEKILLDPNSEEVSEKDAKQIIETA :::::::::: :. :::.::::. . :.: . ::.:..::: ::..:::.: NP_001 VAPRSDSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENA 660 670 680 690 700 710 690 700 710 720 730 740 pF1KE0 KQDVDDEYSM-QYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYN ::::::::.. : ::: ::::.::::..:::.:::::..::.::.::..::::.::::: NP_001 KQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYN 720 730 740 750 760 770 750 760 770 780 790 800 pF1KE0 NNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVV :::::::::::::::::::::::::::::::.:::.::::::::::::.::::::::::: NP_001 NNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVV 780 790 800 810 820 830 810 820 830 840 850 860 pF1KE0 KISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHH :.::::.:: ::..:::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHH 840 850 860 870 880 890 870 880 890 900 910 920 pF1KE0 CKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: NP_001 CKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT 900 910 920 930 940 950 930 940 950 960 970 980 pF1KE0 GERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRH ::.::::::::::::::::::::::::::::::::.::::::::::::::::::..:::: NP_001 GEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRH 960 970 980 990 1000 1010 990 1000 1010 1020 1030 1040 pF1KE0 MQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVI :::::.:::::::::::::::.:::::::::::::::::::::::::::.::::...:.. NP_001 MQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIV 1020 1030 1040 1050 1060 1070 1050 1060 1070 1080 1090 1100 pF1KE0 NGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTT .: .:::::::::::::::::::::::.:::::::::::::::::::.:.: :::::::: NP_001 QGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTT 1080 1090 1100 1110 1120 1130 1110 1120 1130 1140 1150 1160 pF1KE0 KSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRA :.:::. ::: ::::::.::::::::::::::::::.::::.:::::::::::::::::: NP_001 KAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRA 1140 1150 1160 1170 1180 1190 1170 1180 1190 1200 1210 1220 pF1KE0 HRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAI 1200 1210 1220 1230 1240 1250 1230 1240 1250 1260 1270 1280 pF1KE0 LEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDEL :::::..:::::::::::.::::::.:::::::::::.:::::.:::::::::::::::: NP_001 LEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDEL 1260 1270 1280 1290 1300 1310 1290 1300 1310 1320 1330 pF1KE0 PSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTEKQWLR---AIEDGNLEEM ::::::::::::::::::::::.::::::.:..:::::.:::::::. :::.:.:::. NP_001 PSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKTLKAIEEGTLEEI 1320 1330 1340 1350 1360 1370 1340 1350 1360 1370 1380 pF1KE0 EEEVRLKKRKRRRNVDKD-----PA-------KEDVEKAKKRRGRPPAEKLSPNPPKLTK ::::: :: .:.:. :.: :. :.: : .:.::::::::::::::.::: NP_001 EEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTK 1380 1390 1400 1410 1420 1430 1390 1400 1410 1420 1430 1440 pF1KE0 QMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRS .:. :.:.::.::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRS 1440 1450 1460 1470 1480 1490 1450 1460 1470 1480 1490 1500 pF1KE0 LGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEDESNEEEEEE :.::::::::::.:::::::::: :::::::::::: :.:::: ::..:: : .::::: NP_001 LNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEG 1500 1510 1520 1530 1540 1550 1510 1520 1530 1540 1550 1560 pF1KE0 DEEESESEAKSVKVKIKLNKKDDKGRDKGKG-KKRPNRG-KAKPVVSDFDSDEEQDEREQ .:: ::::..::::::::..:. :..:. :: ..::.:: .::::::: ::.:::.: .. NP_001 EEEGSESESRSVKVKIKLGRKE-KAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRS 1560 1570 1580 1590 1600 1570 pF1KE0 SEGSGTDDE . :: : NP_001 GSGSEED 1610 >>NP_001122317 (OMIM: 603254,613325,614609) transcriptio (1617 aa) initn: 6989 init1: 3931 opt: 6313 Z-score: 2222.9 bits: 424.2 E(85289): 4.5e-117 Smith-Waterman score: 8113; 76.4% identity (88.8% similar) in 1628 aa overlap (1-1570:1-1617) 10 20 30 40 50 pF1KE0 MSTPTDP-GAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPT :::: : :. :.:::::::::::: .::::::: ::::.::::::::::::..::.:: NP_001 MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGP--SPGSAHSMMGPSPGPPSAGHPIPT 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 MGSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPP-HPGMGPPQSPMDQHSQ .: .::..:::::::....:.::. .: . ..::: ::: : ::::: :::::::: NP_001 QGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GYMSPHPSPLGAPEHVSSPMSGGGPTP-PQMPPSQPGALIPG-DPQAMSQPNRGPSPFSP :: :::::. ::.:::. ..::. ::: . :: . : ::::..: ::::.::. NP_001 GY----PSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQ 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 VQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQ---------- :::::::::.::::::::::::. ::.:::::: .::.:::. . NP_001 NQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGP 180 190 200 210 220 230 230 240 250 260 270 pF1KE0 -----------QQQQQQQQQQQQPQQQPPQPQT----QQQQQPALVNYNRPSGPGPELSG . .. . . :.. :: :. . : :. : :: . .. NP_001 GPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAA 240 250 260 270 280 290 280 290 300 310 320 pF1KE0 P-STPQKLPVPAPGGRPSPAPPAAAQPPAAA-VPGPSVPQPA-PGQPSPVLQLQQKQSRI : :::::: : : :::::::::. ::::. : :.. .:. :.::.:.. :.:::::: NP_001 PTSTPQKLIPPQPTGRPSPAPPAV--PPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRI 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE0 SPIQKPQGLDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNF .:::::.::::::::::::::::::::::::::::::::: :::::::.:::::::::: NP_001 TPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNF 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE0 QRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKH :::::::::.::::::.::::::.:::::::::.:::::.:::::::::::::::::::: NP_001 QRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKH 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE0 QEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMA :::::::::::::::::::::.::::::.:::::.:::::::::::.::::::::::::: NP_001 QEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMA 480 490 500 510 520 530 510 520 530 540 550 560 pF1KE0 EDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEE :::::::::::::::.:::::::::::::::::.:: .:: ::.::::::....:: : NP_001 EDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKK--AE 540 550 560 570 580 590 570 580 590 600 610 620 pF1KE0 NAEGGESALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYE :::: :.::::::.::.:::::::::: :.:.::.: : .::::.::.:::::::::: NP_001 NAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYE 600 610 620 630 640 650 630 640 650 660 670 680 pF1KE0 VAPRSDSEESDSDYEEEDEEEESSRQET-------EEKILLDPNSEEVSEKDAKQIIETA :::::::::: :. :::.::::. . :.: . ::.:..::: ::..:::.: NP_001 VAPRSDSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENA 660 670 680 690 700 710 690 700 710 720 730 740 pF1KE0 KQDVDDEYSM-QYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYN ::::::::.. : ::: ::::.::::..:::.:::::..::.::.::..::::.::::: NP_001 KQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYN 720 730 740 750 760 770 750 760 770 780 790 800 pF1KE0 NNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVV :::::::::::::::::::::::::::::::.:::.::::::::::::.::::::::::: NP_001 NNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVV 780 790 800 810 820 830 810 820 830 840 850 860 pF1KE0 KISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHH :.::::.:: ::..:::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHH 840 850 860 870 880 890 870 880 890 900 910 920 pF1KE0 CKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: NP_001 CKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT 900 910 920 930 940 950 930 940 950 960 970 980 pF1KE0 GERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRH ::.::::::::::::::::::::::::::::::::.::::::::::::::::::..:::: NP_001 GEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRH 960 970 980 990 1000 1010 990 1000 1010 1020 1030 1040 pF1KE0 MQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVI :::::.:::::::::::::::.:::::::::::::::::::::::::::.::::...:.. NP_001 MQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIV 1020 1030 1040 1050 1060 1070 1050 1060 1070 1080 1090 1100 pF1KE0 NGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTT .: .:::::::::::::::::::::::.:::::::::::::::::::.:.: :::::::: NP_001 QGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTT 1080 1090 1100 1110 1120 1130 1110 1120 1130 1140 1150 1160 pF1KE0 KSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRA :.:::. ::: ::::::.::::::::::::::::::.::::.:::::::::::::::::: NP_001 KAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRA 1140 1150 1160 1170 1180 1190 1170 1180 1190 1200 1210 1220 pF1KE0 HRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAI 1200 1210 1220 1230 1240 1250 1230 1240 1250 1260 1270 1280 pF1KE0 LEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDEL :::::..:::::::::::.::::::.:::::::::::.:::::.:::::::::::::::: NP_001 LEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDEL 1260 1270 1280 1290 1300 1310 1290 1300 1310 1320 1330 pF1KE0 PSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTEKQWLR---AIEDGNLEEM ::::::::::::::::::::::.::::::.:..:::::.:::::::. :::.:.:::. NP_001 PSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKTLKAIEEGTLEEI 1320 1330 1340 1350 1360 1370 1340 1350 1360 1370 1380 pF1KE0 EEEVRLKKRKRRRNVDKD-----PA-------KEDVEKAKKRRGRPPAEKLSPNPPKLTK ::::: :: .:.:. :.: :. :.: : .:.::::::::::::::.::: NP_001 EEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTK 1380 1390 1400 1410 1420 1430 1390 1400 1410 1420 1430 1440 pF1KE0 QMNAIIDTVINYKDSS-GRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYR .:. :.:.::.::::: ::::::::::::::::::::::::::::::::::::::::::: NP_001 KMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYR 1440 1450 1460 1470 1480 1490 1450 1460 1470 1480 1490 1500 pF1KE0 SLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEDESNEEEEE ::.::::::::::.:::::::::: :::::::::::: :.:::: ::..:: : .::::: NP_001 SLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEE 1500 1510 1520 1530 1540 1550 1510 1520 1530 1540 1550 1560 pF1KE0 EDEEESESEAKSVKVKIKLNKKDDKGRDKGKG-KKRPNRG-KAKPVVSDFDSDEEQDERE .:: ::::..::::::::..:. :..:. :: ..::.:: .::::::: ::.:::.: . NP_001 GEEEGSESESRSVKVKIKLGRKE-KAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDR 1560 1570 1580 1590 1600 1570 pF1KE0 QSEGSGTDDE .. :: : NP_001 SGSGSEED 1610 1572 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 11:15:55 2016 done: Sun Nov 6 11:15:58 2016 Total Scan time: 21.580 Total Display time: 1.180 Function used was FASTA [36.3.4 Apr, 2011]