FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2619, 456 aa 1>>>pF1KE2619 456 - 456 aa - 456 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0993+/-0.000479; mu= 12.3601+/- 0.030 mean_var=68.0131+/-13.991, 0's: 0 Z-trim(108.2): 209 B-trim: 33 in 1/51 Lambda= 0.155517 statistics sampled from 16095 (16307) to 16095 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.544), E-opt: 0.2 (0.191), width: 16 Scan time: 7.540 The best scores are: opt bits E(85289) NP_002594 (OMIM: 171885) high affinity cAMP-specif ( 456) 3058 695.8 6e-200 XP_011515842 (OMIM: 171885) PREDICTED: high affini ( 456) 3058 695.8 6e-200 NP_001229247 (OMIM: 171885) high affinity cAMP-spe ( 482) 2930 667.1 2.8e-191 XP_016869027 (OMIM: 171885) PREDICTED: high affini ( 448) 2925 666.0 5.7e-191 XP_011534057 (OMIM: 604645) PREDICTED: cAMP-specif ( 489) 1851 425.0 2.1e-118 NP_061818 (OMIM: 604645) cAMP-specific 3',5'-cycli ( 450) 1846 423.9 4.3e-118 XP_005266988 (OMIM: 604645) PREDICTED: cAMP-specif ( 502) 1806 414.9 2.4e-115 XP_016866230 (OMIM: 604645) PREDICTED: cAMP-specif ( 343) 1546 356.6 6.1e-98 NP_001092289 (OMIM: 600128) cAMP-specific 3',5'-cy ( 606) 740 175.8 2.9e-43 XP_011526358 (OMIM: 600128) PREDICTED: cAMP-specif ( 606) 740 175.8 2.9e-43 NP_001092288 (OMIM: 600128) cAMP-specific 3',5'-cy ( 680) 740 175.8 3.2e-43 NP_001317101 (OMIM: 600128) cAMP-specific 3',5'-cy ( 712) 740 175.8 3.3e-43 NP_000914 (OMIM: 600128) cAMP-specific 3',5'-cycli ( 712) 740 175.8 3.3e-43 XP_005270981 (OMIM: 600127) PREDICTED: cAMP-specif ( 517) 738 175.3 3.4e-43 XP_005270982 (OMIM: 600127) PREDICTED: cAMP-specif ( 517) 738 175.3 3.4e-43 XP_016856935 (OMIM: 600127) PREDICTED: cAMP-specif ( 530) 738 175.3 3.4e-43 XP_011539868 (OMIM: 600127) PREDICTED: cAMP-specif ( 530) 738 175.3 3.4e-43 XP_006710743 (OMIM: 600127) PREDICTED: cAMP-specif ( 531) 738 175.3 3.4e-43 XP_016865060 (OMIM: 600129,606799,614613) PREDICTE ( 553) 738 175.3 3.6e-43 XP_016865059 (OMIM: 600129,606799,614613) PREDICTE ( 553) 738 175.3 3.6e-43 NP_001032416 (OMIM: 600127) cAMP-specific 3',5'-cy ( 564) 738 175.3 3.6e-43 NP_001184151 (OMIM: 600129,606799,614613) cAMP-spe ( 585) 738 175.3 3.8e-43 XP_016856934 (OMIM: 600127) PREDICTED: cAMP-specif ( 597) 738 175.3 3.8e-43 NP_001284369 (OMIM: 600127) cAMP-specific 3',5'-cy ( 644) 738 175.3 4.1e-43 NP_001284370 (OMIM: 600127) cAMP-specific 3',5'-cy ( 661) 738 175.3 4.2e-43 XP_011541779 (OMIM: 600129,606799,614613) PREDICTE ( 662) 738 175.3 4.2e-43 XP_005248595 (OMIM: 600129,606799,614613) PREDICTE ( 673) 738 175.3 4.3e-43 NP_006194 (OMIM: 600129,606799,614613) cAMP-specif ( 673) 738 175.3 4.3e-43 NP_001184149 (OMIM: 600129,606799,614613) cAMP-spe ( 679) 738 175.3 4.3e-43 NP_001184148 (OMIM: 600129,606799,614613) cAMP-spe ( 687) 738 175.3 4.4e-43 XP_016865058 (OMIM: 600129,606799,614613) PREDICTE ( 699) 738 175.3 4.5e-43 XP_005248594 (OMIM: 600129,606799,614613) PREDICTE ( 699) 738 175.3 4.5e-43 NP_001032417 (OMIM: 600127) cAMP-specific 3',5'-cy ( 721) 738 175.3 4.6e-43 NP_001032418 (OMIM: 600127) cAMP-specific 3',5'-cy ( 736) 738 175.3 4.7e-43 NP_002591 (OMIM: 600127) cAMP-specific 3',5'-cycli ( 736) 738 175.3 4.7e-43 XP_016865057 (OMIM: 600129,606799,614613) PREDICTE ( 738) 738 175.3 4.7e-43 XP_016865056 (OMIM: 600129,606799,614613) PREDICTE ( 743) 738 175.4 4.7e-43 NP_001184147 (OMIM: 600129,606799,614613) cAMP-spe ( 745) 738 175.4 4.7e-43 XP_011541775 (OMIM: 600129,606799,614613) PREDICTE ( 748) 738 175.4 4.8e-43 XP_016865055 (OMIM: 600129,606799,614613) PREDICTE ( 748) 738 175.4 4.8e-43 XP_011541773 (OMIM: 600129,606799,614613) PREDICTE ( 748) 738 175.4 4.8e-43 NP_001159371 (OMIM: 600129,606799,614613) cAMP-spe ( 748) 738 175.4 4.8e-43 XP_011526360 (OMIM: 600128) PREDICTED: cAMP-specif ( 481) 735 174.6 5e-43 XP_011541771 (OMIM: 600129,606799,614613) PREDICTE ( 797) 738 175.4 5.1e-43 XP_016865054 (OMIM: 600129,606799,614613) PREDICTE ( 797) 738 175.4 5.1e-43 XP_011541772 (OMIM: 600129,606799,614613) PREDICTE ( 797) 738 175.4 5.1e-43 NP_001098101 (OMIM: 600129,606799,614613) cAMP-spe ( 809) 738 175.4 5.1e-43 NP_001284371 (OMIM: 600127) cAMP-specific 3',5'-cy ( 503) 727 172.9 1.8e-42 NP_001184150 (OMIM: 600129,606799,614613) cAMP-spe ( 507) 722 171.7 4e-42 NP_001184152 (OMIM: 600129,606799,614613) cAMP-spe ( 518) 722 171.7 4e-42 >>NP_002594 (OMIM: 171885) high affinity cAMP-specific 3 (456 aa) initn: 3058 init1: 3058 opt: 3058 Z-score: 3710.6 bits: 695.8 E(85289): 6e-200 Smith-Waterman score: 3058; 100.0% identity (100.0% similar) in 456 aa overlap (1-456:1-456) 10 20 30 40 50 60 pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGL 370 380 390 400 410 420 430 440 450 pF1KE2 NKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS :::::::::::::::::::::::::::::::::::: NP_002 NKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS 430 440 450 >>XP_011515842 (OMIM: 171885) PREDICTED: high affinity c (456 aa) initn: 3058 init1: 3058 opt: 3058 Z-score: 3710.6 bits: 695.8 E(85289): 6e-200 Smith-Waterman score: 3058; 100.0% identity (100.0% similar) in 456 aa overlap (1-456:1-456) 10 20 30 40 50 60 pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGL 370 380 390 400 410 420 430 440 450 pF1KE2 NKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS :::::::::::::::::::::::::::::::::::: XP_011 NKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS 430 440 450 >>NP_001229247 (OMIM: 171885) high affinity cAMP-specifi (482 aa) initn: 2930 init1: 2930 opt: 2930 Z-score: 3555.0 bits: 667.1 E(85289): 2.8e-191 Smith-Waterman score: 2930; 99.8% identity (100.0% similar) in 438 aa overlap (19-456:45-482) 10 20 30 40 pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSR :.:::::::::::::::::::::::::::: NP_001 PVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSR 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE2 AGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLN 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE2 ILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKL 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE2 RRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDL 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE2 DHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQI 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE2 GALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSK 320 330 340 350 360 370 350 360 370 380 390 400 pF1KE2 QWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNT 380 390 400 410 420 430 410 420 430 440 450 pF1KE2 RLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS 440 450 460 470 480 >>XP_016869027 (OMIM: 171885) PREDICTED: high affinity c (448 aa) initn: 2925 init1: 2925 opt: 2925 Z-score: 3549.5 bits: 666.0 E(85289): 5.7e-191 Smith-Waterman score: 2925; 99.8% identity (100.0% similar) in 437 aa overlap (20-456:12-448) 10 20 30 40 50 60 pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP .:::::::::::::::::::::::::::::::::::::::: XP_016 MWMEHQLFQGCQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE2 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGL 360 370 380 390 400 410 430 440 450 pF1KE2 NKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS :::::::::::::::::::::::::::::::::::: XP_016 NKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS 420 430 440 >>XP_011534057 (OMIM: 604645) PREDICTED: cAMP-specific 3 (489 aa) initn: 1834 init1: 1764 opt: 1851 Z-score: 2246.6 bits: 425.0 E(85289): 2.1e-118 Smith-Waterman score: 1851; 61.9% identity (86.5% similar) in 423 aa overlap (20-441:46-468) 10 20 30 40 pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRA :: : : ... ::.: . ::::.:.:... XP_011 FSSLQAKSRKANIYSPDSLLQSPHPSSLLIKRCGEILFENPDQNAKCVCMLGDIRLRGQT 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE2 GFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNI : ..:::::.:.::::...: . . ....::::::::...::..:: . :.. XP_011 GVRAERRGSYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHL 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE2 LDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLR ::.:: :::. :: ::: :.::::::::::::::::.: :::. ::::..:.:::. :. XP_011 LDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLH 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE2 RFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLD :::::.:::::::::::::::::::::::::::::::::. .:: ::.:.:.:::.::.: XP_011 RFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVD 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE2 HPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIG ::::::::::::::.::.::.: ::::::::::..:.:::: :..::: : :..: :.: XP_011 HPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLG 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE2 ALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQ .:::::::.::::.:. ...:: :: :::.. ::..::.:::::::::::: ::.::: XP_011 SLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQ 320 330 340 350 360 370 350 360 370 380 390 400 pF1KE2 WSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFS-NT :::.: :::..::..:.:..: .::::... .:: .::::::.:.::::: :::.:. :. XP_011 WSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNS 380 390 400 410 420 430 410 420 430 440 450 pF1KE2 RLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS ::..::::.. :::.::.: .: :. .... XP_011 TLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP 440 450 460 470 480 >>NP_061818 (OMIM: 604645) cAMP-specific 3',5'-cyclic ph (450 aa) initn: 1810 init1: 1740 opt: 1846 Z-score: 2241.1 bits: 423.9 E(85289): 4.3e-118 Smith-Waterman score: 1846; 61.7% identity (86.5% similar) in 423 aa overlap (20-441:7-429) 10 20 30 40 50 60 pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP .: : : ... ::.: . ::::.:.:...: ..:::::.: NP_061 MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYP 10 20 30 40 70 80 90 100 110 120 pF1KE2 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC .::::...: . . ....::::::::...::..:: . :..::.:: :::. NP_061 FIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARH 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE2 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH :: ::: :.::::::::::::::::.: :::. ::::..:.:::. :.:::::.::::: NP_061 MLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYH 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE2 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK ::::::::::::::::::::::::::::. .:: ::.:.:.:::.::.:::::::::::: NP_061 SQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIK 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE2 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ :::.::.::.: ::::::::::..:.:::: :..::: : :..: :.:.:::::::.:: NP_061 TNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQ 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE2 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH ::.:. ...:: :: :::.. ::..::.:::::::::::: ::.::::::.: :::.. NP_061 NEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYR 290 300 310 320 330 340 370 380 390 400 410 pF1KE2 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFS-NTRLSQTMLGHVG ::..:.:..: .::::... .:: .::::::.:.::::: :::.:. :. ::..::::.. NP_061 QGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLA 350 360 370 380 390 400 420 430 440 450 pF1KE2 LNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS :::.::.: .: :. .... NP_061 HNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP 410 420 430 440 450 >>XP_005266988 (OMIM: 604645) PREDICTED: cAMP-specific 3 (502 aa) initn: 1784 init1: 1714 opt: 1806 Z-score: 2191.8 bits: 414.9 E(85289): 2.4e-115 Smith-Waterman score: 1806; 60.8% identity (85.4% similar) in 424 aa overlap (19-441:63-481) 10 20 30 40 pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSR .:.:: . :. : . ::.:.:.. XP_005 GCQQGPLPWDLPEMIRMVKLVWKSKSELQATKQRGIL--DNEDALRSFP---GDIRLRGQ 40 50 60 70 80 50 60 70 80 90 100 pF1KE2 AGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLN .: ..:::::.:.::::...: . . ....::::::::...::..:: . :. XP_005 TGVRAERRGSYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLH 90 100 110 120 130 140 110 120 130 140 150 160 pF1KE2 ILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKL .::.:: :::. :: ::: :.::::::::::::::::.: :::. ::::..:.:::. : XP_005 LLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTL 150 160 170 180 190 200 170 180 190 200 210 220 pF1KE2 RRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDL .:::::.:::::::::::::::::::::::::::::::::. .:: ::.:.:.:::.::. XP_005 HRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDV 210 220 230 240 250 260 230 240 250 260 270 280 pF1KE2 DHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQI :::::::::::::::.::.::.: ::::::::::..:.:::: :..::: : :..: :. XP_005 DHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQL 270 280 290 300 310 320 290 300 310 320 330 340 pF1KE2 GALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSK :.:::::::.::::.:. ...:: :: :::.. ::..::.:::::::::::: ::.:: XP_005 GSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSK 330 340 350 360 370 380 350 360 370 380 390 400 pF1KE2 QWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFS-N ::::.: :::..::..:.:..: .::::... .:: .::::::.:.::::: :::.:. : XP_005 QWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGN 390 400 410 420 430 440 410 420 430 440 450 pF1KE2 TRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS . ::..::::.. :::.::.: .: :. .... XP_005 STLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP 450 460 470 480 490 500 >>XP_016866230 (OMIM: 604645) PREDICTED: cAMP-specific 3 (343 aa) initn: 1529 init1: 1459 opt: 1546 Z-score: 1879.4 bits: 356.6 E(85289): 6.1e-98 Smith-Waterman score: 1546; 67.4% identity (89.4% similar) in 322 aa overlap (121-441:1-322) 100 110 120 130 140 150 pF1KE2 YLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFH :: ::: :.::::::::::::::::.: : XP_016 MLSKVGMWDFDIFLFDRLTNGNSLVTLLCH 10 20 30 160 170 180 190 200 210 pF1KE2 LFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANS ::. ::::..:.:::. :.:::::.:::::::::::::::::::::::::::::::::. XP_016 LFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASF 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE2 VTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES .:: ::.:.:.:::.::.:::::::::::::::.::.::.: ::::::::::..:.:::: XP_016 LTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRES 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE2 GLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQM :..::: : :..: :.:.:::::::.::::.:. ...:: :: :::.. ::..::. XP_016 RLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQI 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE2 ALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGF :::::::::::: ::.::::::.: :::..::..:.:..: .::::... .:: .::::: XP_016 ALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGF 220 230 240 250 260 270 400 410 420 430 440 pF1KE2 MTYLVEPLFTEWARFS-NTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLL :.:.::::: :::.:. :. ::..::::.. :::.::.: .: :. .... XP_016 MSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAG 280 290 300 310 320 330 450 pF1KE2 PQENRLS XP_016 QGTESEEQEGDSP 340 >>NP_001092289 (OMIM: 600128) cAMP-specific 3',5'-cyclic (606 aa) initn: 581 init1: 289 opt: 740 Z-score: 897.8 bits: 175.8 E(85289): 2.9e-43 Smith-Waterman score: 740; 30.7% identity (62.4% similar) in 449 aa overlap (5-439:107-541) 10 20 30 pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTA : ::: . : . : ... .:.. NP_001 QGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLE----TLQTRHSVGEMASNKFK 80 90 100 110 120 130 40 50 60 70 80 pF1KE2 LYI-RMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEV-SVSARN----IRRLLSF . : : . ::.: . . :. ..: .:.:.:. .:.:.. . :. .. NP_001 RILNRELTHLSETSRSGNQVSEYISRTFLD-----QQTEVELPKVTAEEAPQPMSRISGL 140 150 160 170 180 90 100 110 120 130 140 pF1KE2 QRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLT . .:. . ..:. ... :. . :: :: ...:..:.: .:... :... NP_001 HGLCHSASL--SSATVPRFGVQTDQEEQLAK-ELEDTNKWGLDVFKVAELSGNRPLTAII 190 200 210 220 230 240 150 160 170 180 190 200 pF1KE2 FHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLA : .:. . :.. :.. : .:.:.. ::.. :::..:::::.:. : : : : NP_001 FSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALE 250 260 270 280 290 300 210 220 230 240 250 260 pF1KE2 NSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLR : .:: .:.:.: ::.:::::.. :::.:: :: .:...::::::: . ::. NP_001 AVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQ 310 320 330 340 350 360 270 280 290 300 310 320 pF1KE2 ESG--LFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDR------GDLCLED . .:..: ..: ... .. ..::::.:.. . :. ... .. : : :.. NP_001 AENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDN 370 380 390 400 410 420 330 340 350 360 370 380 pF1KE2 TRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHT : ::: ..:::. :: . : .::.... :::.::: :.. : .::.::.:: NP_001 YSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHT 430 440 450 460 470 480 390 400 410 420 430 440 pF1KE2 ESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDA :. . :.::. :...::. :: . . .: .: . :. : . .: :. :. NP_001 ASVEKSQVGFIDYIAHPLWETWADLVHPD-AQDLLDTLEDNRE-WYQSKIPRSPSDLTNP 490 500 510 520 530 540 450 pF1KE2 AFELNSQLLPQENRLS NP_001 ERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLD 550 560 570 580 590 600 >>XP_011526358 (OMIM: 600128) PREDICTED: cAMP-specific 3 (606 aa) initn: 581 init1: 289 opt: 740 Z-score: 897.8 bits: 175.8 E(85289): 2.9e-43 Smith-Waterman score: 740; 30.7% identity (62.4% similar) in 449 aa overlap (5-439:107-541) 10 20 30 pF1KE2 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTA : ::: . : . : ... .:.. XP_011 QGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLE----TLQTRHSVGEMASNKFK 80 90 100 110 120 130 40 50 60 70 80 pF1KE2 LYI-RMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEV-SVSARN----IRRLLSF . : : . ::.: . . :. ..: .:.:.:. .:.:.. . :. .. XP_011 RILNRELTHLSETSRSGNQVSEYISRTFLD-----QQTEVELPKVTAEEAPQPMSRISGL 140 150 160 170 180 90 100 110 120 130 140 pF1KE2 QRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLT . .:. . ..:. ... :. . :: :: ...:..:.: .:... :... XP_011 HGLCHSASL--SSATVPRFGVQTDQEEQLAK-ELEDTNKWGLDVFKVAELSGNRPLTAII 190 200 210 220 230 240 150 160 170 180 190 200 pF1KE2 FHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLA : .:. . :.. :.. : .:.:.. ::.. :::..:::::.:. : : : : XP_011 FSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALE 250 260 270 280 290 300 210 220 230 240 250 260 pF1KE2 NSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLR : .:: .:.:.: ::.:::::.. :::.:: :: .:...::::::: . ::. XP_011 AVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQ 310 320 330 340 350 360 270 280 290 300 310 320 pF1KE2 ESG--LFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDR------GDLCLED . .:..: ..: ... .. ..::::.:.. . :. ... .. : : :.. XP_011 AENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDN 370 380 390 400 410 420 330 340 350 360 370 380 pF1KE2 TRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHT : ::: ..:::. :: . : .::.... :::.::: :.. : .::.::.:: XP_011 YSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHT 430 440 450 460 470 480 390 400 410 420 430 440 pF1KE2 ESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDA :. . :.::. :...::. :: . . .: .: . :. : . .: :. :. XP_011 ASVEKSQVGFIDYIAHPLWETWADLVHPD-AQDLLDTLEDNRE-WYQSKIPRSPSDLTNP 490 500 510 520 530 540 450 pF1KE2 AFELNSQLLPQENRLS XP_011 ERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLD 550 560 570 580 590 600 456 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 17:12:52 2016 done: Tue Nov 8 17:12:53 2016 Total Scan time: 7.540 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]