Result of FASTA (omim) for
pFN21AE5734
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5734, 660 aa
1>>>pF1KE5734 660 - 660 aa - 660 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.5011+/-0.000409; mu= 8.9902+/- 0.026
mean_var=125.2152+/-25.143, 0's: 0 Z-trim(114.5): 100 B-trim: 0 in 0/55
Lambda= 0.114616
statistics sampled from 24238 (24338) to 24238 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.64), E-opt: 0.2 (0.285), width: 16
Scan time: 6.840
The best scores are: opt bits E(85289)
NP_004677 (OMIM: 603562) myotubularin-related prot ( 660) 4485 753.5 5.7e-217
XP_011542994 (OMIM: 603562) PREDICTED: myotubulari ( 439) 2996 507.2 5.3e-143
XP_011542995 (OMIM: 603562) PREDICTED: myotubulari ( 423) 2844 482.0 1.9e-135
XP_006716477 (OMIM: 603562) PREDICTED: myotubulari ( 423) 2844 482.0 1.9e-135
XP_016869445 (OMIM: 603562) PREDICTED: myotubulari ( 372) 2556 434.4 3.7e-121
NP_004676 (OMIM: 603561) myotubularin-related prot ( 621) 2461 418.8 3e-116
XP_016876334 (OMIM: 603561) PREDICTED: myotubulari ( 535) 2317 394.9 3.9e-109
XP_016876335 (OMIM: 603561) PREDICTED: myotubulari ( 426) 1361 236.8 1.3e-61
XP_011533608 (OMIM: 603561) PREDICTED: myotubulari ( 659) 1361 236.9 1.8e-61
XP_005274432 (OMIM: 601382,603557) PREDICTED: myot ( 571) 1251 218.7 4.8e-56
XP_016874007 (OMIM: 601382,603557) PREDICTED: myot ( 571) 1251 218.7 4.8e-56
XP_006718998 (OMIM: 601382,603557) PREDICTED: myot ( 571) 1251 218.7 4.8e-56
XP_006718999 (OMIM: 601382,603557) PREDICTED: myot ( 571) 1251 218.7 4.8e-56
NP_958438 (OMIM: 601382,603557) myotubularin-relat ( 571) 1251 218.7 4.8e-56
NP_958435 (OMIM: 601382,603557) myotubularin-relat ( 571) 1251 218.7 4.8e-56
XP_005274431 (OMIM: 601382,603557) PREDICTED: myot ( 571) 1251 218.7 4.8e-56
XP_016874006 (OMIM: 601382,603557) PREDICTED: myot ( 571) 1251 218.7 4.8e-56
XP_006718997 (OMIM: 601382,603557) PREDICTED: myot ( 571) 1251 218.7 4.8e-56
NP_001230500 (OMIM: 601382,603557) myotubularin-re ( 571) 1251 218.7 4.8e-56
XP_011541361 (OMIM: 601382,603557) PREDICTED: myot ( 596) 1251 218.7 5e-56
XP_011541360 (OMIM: 601382,603557) PREDICTED: myot ( 596) 1251 218.7 5e-56
NP_057240 (OMIM: 601382,603557) myotubularin-relat ( 643) 1251 218.7 5.3e-56
XP_011533609 (OMIM: 603561) PREDICTED: myotubulari ( 573) 1217 213.0 2.4e-54
XP_005274744 (OMIM: 300415,310400) PREDICTED: myot ( 603) 1206 211.2 8.8e-54
XP_011529475 (OMIM: 300415,310400) PREDICTED: myot ( 603) 1206 211.2 8.8e-54
NP_000243 (OMIM: 300415,310400) myotubularin [Homo ( 603) 1206 211.2 8.8e-54
XP_011529474 (OMIM: 300415,310400) PREDICTED: myot ( 618) 1206 211.2 8.9e-54
XP_011529473 (OMIM: 300415,310400) PREDICTED: myot ( 618) 1206 211.2 8.9e-54
XP_016885037 (OMIM: 300415,310400) PREDICTED: myot ( 618) 1206 211.2 8.9e-54
XP_016885038 (OMIM: 300415,310400) PREDICTED: myot ( 602) 1202 210.6 1.4e-53
XP_016885036 (OMIM: 300415,310400) PREDICTED: myot ( 617) 1202 210.6 1.4e-53
NP_056273 (OMIM: 606260) myotubularin-related prot ( 549) 1188 208.2 6.4e-53
XP_016885039 (OMIM: 300415,310400) PREDICTED: myot ( 566) 1176 206.3 2.6e-52
XP_011529511 (OMIM: 300171) PREDICTED: myotubulari ( 571) 1159 203.5 1.8e-51
XP_016885411 (OMIM: 300171) PREDICTED: myotubulari ( 571) 1159 203.5 1.8e-51
XP_016885410 (OMIM: 300171) PREDICTED: myotubulari ( 571) 1159 203.5 1.8e-51
NP_003819 (OMIM: 300171) myotubularin-related prot ( 665) 1159 203.5 2.1e-51
XP_006724918 (OMIM: 300171) PREDICTED: myotubulari ( 665) 1159 203.5 2.1e-51
NP_001293073 (OMIM: 300171) myotubularin-related p ( 673) 1159 203.5 2.1e-51
XP_005274824 (OMIM: 300171) PREDICTED: myotubulari ( 682) 1159 203.5 2.1e-51
XP_005274823 (OMIM: 300171) PREDICTED: myotubulari ( 682) 1159 203.5 2.1e-51
XP_005274822 (OMIM: 300171) PREDICTED: myotubulari ( 699) 1159 203.5 2.2e-51
XP_016885412 (OMIM: 300171) PREDICTED: myotubulari ( 552) 1156 203.0 2.5e-51
XP_016885409 (OMIM: 300171) PREDICTED: myotubulari ( 602) 1069 188.6 5.8e-47
XP_011542132 (OMIM: 606260) PREDICTED: myotubulari ( 442) 991 175.6 3.4e-43
XP_016885040 (OMIM: 300415,310400) PREDICTED: myot ( 355) 886 158.2 4.7e-38
XP_011542133 (OMIM: 606260) PREDICTED: myotubulari ( 353) 794 143.0 1.8e-33
XP_016884522 (OMIM: 603558) PREDICTED: myotubulari (1069) 787 142.1 1e-32
NP_694691 (OMIM: 603558) myotubularin-related prot (1161) 787 142.1 1.1e-32
XP_016884521 (OMIM: 603558) PREDICTED: myotubulari (1161) 787 142.1 1.1e-32
>>NP_004677 (OMIM: 603562) myotubularin-related protein (660 aa)
initn: 4485 init1: 4485 opt: 4485 Z-score: 4016.3 bits: 753.5 E(85289): 5.7e-217
Smith-Waterman score: 4485; 99.8% identity (99.8% similar) in 660 aa overlap (1-660:1-660)
10 20 30 40 50 60
pF1KE5 MEHIRTPKVENVRLVDRVSPKKAALGTLYLTATHVIFVENSPDARKETWILHSQISTIEK
::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
NP_004 MEHIRTPKVENVRLVDRVSPKKAALGTLYLTATHVIFVENSPDPRKETWILHSQISTIEK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 QATTATGCPLLIRCKNFQIIQLIIPQERDCHDVYISLIRLARPVKYEELYCFSFNPMLDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QATTATGCPLLIRCKNFQIIQLIIPQERDCHDVYISLIRLARPVKYEELYCFSFNPMLDK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 EEREQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EEREQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 KFRSRRRFPVLSYYYKDNHASICRSSQPLSGFSARCLEDEQMLQAIRKANPGSDFVYVVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KFRSRRRFPVLSYYYKDNHASICRSSQPLSGFSARCLEDEQMLQAIRKANPGSDFVYVVD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 TRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 LWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 RTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 ERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 QTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPRQSVTDYLMAVKEETQQLEEELEALEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPRQSVTDYLMAVKEETQQLEEELEALEE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE5 RLEKIQKVQLNCTKVKSKQSEPSKHSGFSTSDNSIANTPQDYSGNMKSFPSRSPSQGDED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RLEKIQKVQLNCTKVKSKQSEPSKHSGFSTSDNSIANTPQDYSGNMKSFPSRSPSQGDED
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE5 SALILTQDNLKSSDPDLSANSDQESGVEDLSCRSPSGGEHAPSEDSGKDRDSDEAVFLTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SALILTQDNLKSSDPDLSANSDQESGVEDLSCRSPSGGEHAPSEDSGKDRDSDEAVFLTA
610 620 630 640 650 660
>>XP_011542994 (OMIM: 603562) PREDICTED: myotubularin-re (439 aa)
initn: 2996 init1: 2996 opt: 2996 Z-score: 2688.4 bits: 507.2 E(85289): 5.3e-143
Smith-Waterman score: 2996; 100.0% identity (100.0% similar) in 439 aa overlap (222-660:1-439)
200 210 220 230 240 250
pF1KE5 SYYYKDNHASICRSSQPLSGFSARCLEDEQMLQAIRKANPGSDFVYVVDTRPKLNAMANR
::::::::::::::::::::::::::::::
XP_011 MLQAIRKANPGSDFVYVVDTRPKLNAMANR
10 20 30
260 270 280 290 300 310
pF1KE5 AAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLR
40 50 60 70 80 90
320 330 340 350 360 370
pF1KE5 HIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIE
100 110 120 130 140 150
380 390 400 410 420 430
pF1KE5 KDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHI
160 170 180 190 200 210
440 450 460 470 480 490
pF1KE5 YSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTT
220 230 240 250 260 270
500 510 520 530 540 550
pF1KE5 PCNFMYKFWSGMYNRFEKGMQPRQSVTDYLMAVKEETQQLEEELEALEERLEKIQKVQLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PCNFMYKFWSGMYNRFEKGMQPRQSVTDYLMAVKEETQQLEEELEALEERLEKIQKVQLN
280 290 300 310 320 330
560 570 580 590 600 610
pF1KE5 CTKVKSKQSEPSKHSGFSTSDNSIANTPQDYSGNMKSFPSRSPSQGDEDSALILTQDNLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CTKVKSKQSEPSKHSGFSTSDNSIANTPQDYSGNMKSFPSRSPSQGDEDSALILTQDNLK
340 350 360 370 380 390
620 630 640 650 660
pF1KE5 SSDPDLSANSDQESGVEDLSCRSPSGGEHAPSEDSGKDRDSDEAVFLTA
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSDPDLSANSDQESGVEDLSCRSPSGGEHAPSEDSGKDRDSDEAVFLTA
400 410 420 430
>>XP_011542995 (OMIM: 603562) PREDICTED: myotubularin-re (423 aa)
initn: 2844 init1: 2844 opt: 2844 Z-score: 2552.8 bits: 482.0 E(85289): 1.9e-135
Smith-Waterman score: 2844; 100.0% identity (100.0% similar) in 416 aa overlap (245-660:8-423)
220 230 240 250 260 270
pF1KE5 RCLEDEQMLQAIRKANPGSDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIE
::::::::::::::::::::::::::::::
XP_011 MEIFYLNLNAMANRAAGKGYENEDNYSNIKFQFIGIE
10 20 30
280 290 300 310 320 330
pF1KE5 NIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASV
40 50 60 70 80 90
340 350 360 370 380 390
pF1KE5 LVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKE
100 110 120 130 140 150
400 410 420 430 440 450
pF1KE5 ISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQE
160 170 180 190 200 210
460 470 480 490 500 510
pF1KE5 RTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPR
220 230 240 250 260 270
520 530 540 550 560 570
pF1KE5 QSVTDYLMAVKEETQQLEEELEALEERLEKIQKVQLNCTKVKSKQSEPSKHSGFSTSDNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSVTDYLMAVKEETQQLEEELEALEERLEKIQKVQLNCTKVKSKQSEPSKHSGFSTSDNS
280 290 300 310 320 330
580 590 600 610 620 630
pF1KE5 IANTPQDYSGNMKSFPSRSPSQGDEDSALILTQDNLKSSDPDLSANSDQESGVEDLSCRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IANTPQDYSGNMKSFPSRSPSQGDEDSALILTQDNLKSSDPDLSANSDQESGVEDLSCRS
340 350 360 370 380 390
640 650 660
pF1KE5 PSGGEHAPSEDSGKDRDSDEAVFLTA
::::::::::::::::::::::::::
XP_011 PSGGEHAPSEDSGKDRDSDEAVFLTA
400 410 420
>>XP_006716477 (OMIM: 603562) PREDICTED: myotubularin-re (423 aa)
initn: 2844 init1: 2844 opt: 2844 Z-score: 2552.8 bits: 482.0 E(85289): 1.9e-135
Smith-Waterman score: 2844; 100.0% identity (100.0% similar) in 416 aa overlap (245-660:8-423)
220 230 240 250 260 270
pF1KE5 RCLEDEQMLQAIRKANPGSDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIE
::::::::::::::::::::::::::::::
XP_006 MEIFYLNLNAMANRAAGKGYENEDNYSNIKFQFIGIE
10 20 30
280 290 300 310 320 330
pF1KE5 NIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASV
40 50 60 70 80 90
340 350 360 370 380 390
pF1KE5 LVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKE
100 110 120 130 140 150
400 410 420 430 440 450
pF1KE5 ISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQE
160 170 180 190 200 210
460 470 480 490 500 510
pF1KE5 RTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPR
220 230 240 250 260 270
520 530 540 550 560 570
pF1KE5 QSVTDYLMAVKEETQQLEEELEALEERLEKIQKVQLNCTKVKSKQSEPSKHSGFSTSDNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QSVTDYLMAVKEETQQLEEELEALEERLEKIQKVQLNCTKVKSKQSEPSKHSGFSTSDNS
280 290 300 310 320 330
580 590 600 610 620 630
pF1KE5 IANTPQDYSGNMKSFPSRSPSQGDEDSALILTQDNLKSSDPDLSANSDQESGVEDLSCRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IANTPQDYSGNMKSFPSRSPSQGDEDSALILTQDNLKSSDPDLSANSDQESGVEDLSCRS
340 350 360 370 380 390
640 650 660
pF1KE5 PSGGEHAPSEDSGKDRDSDEAVFLTA
::::::::::::::::::::::::::
XP_006 PSGGEHAPSEDSGKDRDSDEAVFLTA
400 410 420
>>XP_016869445 (OMIM: 603562) PREDICTED: myotubularin-re (372 aa)
initn: 2556 init1: 2556 opt: 2556 Z-score: 2296.3 bits: 434.4 E(85289): 3.7e-121
Smith-Waterman score: 2556; 99.7% identity (100.0% similar) in 372 aa overlap (289-660:1-372)
260 270 280 290 300 310
pF1KE5 NEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLRHIKAIMD
.:::::::::::::::::::::::::::::
XP_016 MCELKSPSMSDFLWGLENSGWLRHIKAIMD
10 20 30
320 330 340 350 360 370
pF1KE5 AGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFG
40 50 60 70 80 90
380 390 400 410 420 430
pF1KE5 HKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGN
100 110 120 130 140 150
440 450 460 470 480 490
pF1KE5 FLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYK
160 170 180 190 200 210
500 510 520 530 540 550
pF1KE5 FWSGMYNRFEKGMQPRQSVTDYLMAVKEETQQLEEELEALEERLEKIQKVQLNCTKVKSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FWSGMYNRFEKGMQPRQSVTDYLMAVKEETQQLEEELEALEERLEKIQKVQLNCTKVKSK
220 230 240 250 260 270
560 570 580 590 600 610
pF1KE5 QSEPSKHSGFSTSDNSIANTPQDYSGNMKSFPSRSPSQGDEDSALILTQDNLKSSDPDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSEPSKHSGFSTSDNSIANTPQDYSGNMKSFPSRSPSQGDEDSALILTQDNLKSSDPDLS
280 290 300 310 320 330
620 630 640 650 660
pF1KE5 ANSDQESGVEDLSCRSPSGGEHAPSEDSGKDRDSDEAVFLTA
::::::::::::::::::::::::::::::::::::::::::
XP_016 ANSDQESGVEDLSCRSPSGGEHAPSEDSGKDRDSDEAVFLTA
340 350 360 370
>>NP_004676 (OMIM: 603561) myotubularin-related protein (621 aa)
initn: 2449 init1: 2172 opt: 2461 Z-score: 2207.9 bits: 418.8 E(85289): 3e-116
Smith-Waterman score: 2472; 57.4% identity (81.4% similar) in 636 aa overlap (1-632:1-621)
10 20 30 40 50
pF1KE5 MEHIRTPKVENVRLVDRVSPKKAAL-GTLYLTATHVIFVENSPDARKETWILHSQISTIE
:::::: :::.:.:.:: : .. .: :::::::::..:... .::::::: .:...:
NP_004 MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSH---QKETWILHHHIASVE
10 20 30 40 50
60 70 80 90 100 110
pF1KE5 KQATTATGCPLLIRCKNFQIIQLIIPQERDCHDVYISLIRLARPVKYEELYCFSFNPMLD
: : :..::::.:.::::. ...:.:.::::::.: ::..:.. .:::.:: ::.:: .
NP_004 KLALTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 KEEREQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGS
:: ::: ::::.::: :::.:: .:::::.::::..:..:: :::::. :. :::::
NP_004 DSERLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 SKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFSARCLEDEQMLQAIRKANPGSDFVYVV
:::::. ::::::::..:..:.::: :::::::::::::::..:::: :::: . ..::.
NP_004 SKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVM
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE5 DTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSD
:::::::::::::::::::::::::::.:::.:::::::::.::::.::: :. :..:
NP_004 DTRPKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVND
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE5 FLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPH
: :::.:::::::::.:::.::.:::.. :.::::::::::::::.::::..::::: .
NP_004 FYSGLESSGWLRHIKAVMDAAIFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSY
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE5 YRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEF
:::.::::::::::::::::::..: :.:::::::.:::. ::.::::.: :::: ::::
NP_004 YRTIKGFMVLIEKDWISFGHKFSERCGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEF
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE5 NERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADH
.: ::..:..::.:::::::: : ::::.:::..:.::::: : ... :::::. ..
NP_004 SEAFLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSES
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE5 SQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPRQSVTDYLMAVKEETQQLEEELEALE
. :. :.: .: .::: .::..:.. ..::::: . .: ..:...:::.... ::
NP_004 HRF--TVLEPNT-VSFNFKFWRNMYHQFDRTLHPRQSVFNIIMNMNEQNKQLEKDIKDLE
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE5 ERLEKIQKVQLNCTKVKSKQSEPSKHS---GFSTSDNSIANTPQDYSGNMKSFPSRSPSQ
.... .. : . . .:. : : ...:: .: . .... . ::.
NP_004 SKIKQRKNKQTD--GILTKELLHSVHPESPNLKTSLCFKEQTLLPVNDALRTIEGSSPA-
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE5 GDEDSALILTQDNLKSSDPDLSANSDQESGVEDLSCRSPSGGEHAPSEDSGKDRDSDEAV
:. .....:.: : . : :: ..:
NP_004 ---DNRYSEYAEEFSKSEP---AVVSLEYGVARMTC
600 610 620
660
pF1KE5 FLTA
>>XP_016876334 (OMIM: 603561) PREDICTED: myotubularin-re (535 aa)
initn: 2310 init1: 2171 opt: 2317 Z-score: 2080.2 bits: 394.9 E(85289): 3.9e-109
Smith-Waterman score: 2317; 63.7% identity (85.5% similar) in 523 aa overlap (1-522:1-517)
10 20 30 40 50
pF1KE5 MEHIRTPKVENVRLVDRVSPKKAAL-GTLYLTATHVIFVENSPDARKETWILHSQISTIE
:::::: :::.:.:.:: : .. .: :::::::::..:... .::::::: .:...:
XP_016 MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSH---QKETWILHHHIASVE
10 20 30 40 50
60 70 80 90 100 110
pF1KE5 KQATTATGCPLLIRCKNFQIIQLIIPQERDCHDVYISLIRLARPVKYEELYCFSFNPMLD
: : :..::::.:.::::. ...:.:.::::::.: ::..:.. .:::.:: ::.:: .
XP_016 KLALTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 KEEREQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGS
:: ::: ::::.::: :::.:: .:::::.::::..:..:: :::::. :. :::::
XP_016 DSERLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 SKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFSARCLEDEQMLQAIRKANPGSDFVYVV
:::::. ::::::::..:..:.::: :::::::::::::::..:::: :::: . ..::.
XP_016 SKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVM
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE5 DTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSD
:::::::::::::::::::::::::::.:::.:::::::::.::::.::: :. :..:
XP_016 DTRPKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVND
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE5 FLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPH
: :::.:::::::::.:::.::.:::.. :.::::::::::::::.::::..::::: .
XP_016 FYSGLESSGWLRHIKAVMDAAIFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSY
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE5 YRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEF
:::.::::::::::::::::::..: :.:::::::.:::. ::.::::.: :::: ::::
XP_016 YRTIKGFMVLIEKDWISFGHKFSERCGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEF
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE5 NERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADH
.: ::..:..::.:::::::: : ::::.:::..:.::::: : ... :::::. ..
XP_016 SEAFLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSES
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE5 SQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPRQSVTDYLMAVKEETQQLEEELEALE
. :. :.: .: .: .. . . .::. ....
XP_016 HRF--TVLEPNT-VSFNFKKLNNAKISKQMASSPRNCYIQFILNHLTSKLPCVLKSRLCY
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE5 ERLEKIQKVQLNCTKVKSKQSEPSKHSGFSTSDNSIANTPQDYSGNMKSFPSRSPSQGDE
XP_016 P
>>XP_016876335 (OMIM: 603561) PREDICTED: myotubularin-re (426 aa)
initn: 1348 init1: 1210 opt: 1361 Z-score: 1227.4 bits: 236.8 E(85289): 1.3e-61
Smith-Waterman score: 1372; 53.0% identity (78.0% similar) in 396 aa overlap (240-632:43-426)
210 220 230 240 250 260
pF1KE5 SGFSARCLEDEQMLQAIRKANPGSDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQ
. . .::::::::::::::::::::::.::
XP_016 QSWWATQKDIGRIIVRISSKIQNDEKIRESNEKKRLNAMANRAAGKGYENEDNYSNIRFQ
20 30 40 50 60 70
270 280 290 300 310 320
pF1KE5 FIGIENIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSE
:.:::::::::.::::.::: :. :..:: :::.:::::::::.:::.::.:::..
XP_016 FVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAIFLAKAITV
80 90 100 110 120 130
330 340 350 360 370 380
pF1KE5 EGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLD
:.::::::::::::::.::::..::::: .:::.::::::::::::::::::..: :.::
XP_016 ENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQLD
140 150 160 170 180 190
390 400 410 420 430 440
pF1KE5 GDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRE
:::::.:::. ::.::::.: :::: ::::.: ::..:..::.:::::::: : ::::.:
XP_016 GDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREE
200 210 220 230 240 250
450 460 470 480 490 500
pF1KE5 LKIQERTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYKFWSGMYNRFEK
::..:.::::: : ... :::::. .. . :. :.: .: .::: .::..:..
XP_016 LKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRF--TVLEPNT-VSFNFKFWRNMYHQFDR
260 270 280 290 300
510 520 530 540 550 560
pF1KE5 GMQPRQSVTDYLMAVKEETQQLEEELEALEERLEKIQKVQLNCTKVKSKQSEPSKHS---
..::::: . .: ..:...:::.... :: .... .. : . . .:. : :
XP_016 TLHPRQSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTD--GILTKELLHSVHPESP
310 320 330 340 350 360
570 580 590 600 610 620
pF1KE5 GFSTSDNSIANTPQDYSGNMKSFPSRSPSQGDEDSALILTQDNLKSSDPDLSANSDQESG
...:: .: . .... . ::. :. .....:.: : . : :
XP_016 NLKTSLCFKEQTLLPVNDALRTIEGSSPA----DNRYSEYAEEFSKSEP---AVVSLEYG
370 380 390 400 410 420
630 640 650 660
pF1KE5 VEDLSCRSPSGGEHAPSEDSGKDRDSDEAVFLTA
: ..:
XP_016 VARMTC
>>XP_011533608 (OMIM: 603561) PREDICTED: myotubularin-re (659 aa)
initn: 1487 init1: 1210 opt: 1361 Z-score: 1224.5 bits: 236.9 E(85289): 1.8e-61
Smith-Waterman score: 2358; 53.9% identity (76.7% similar) in 670 aa overlap (5-632:5-659)
10 20 30 40 50
pF1KE5 MEHIRTPKVENVRLVDRVSPKKAAL-GTLYLTATHVIFVENSPDARKETWILHSQISTIE
:: :::.:.:.:: : .. .: :::::::::..:... .::::::: .:...:
XP_011 MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSH---QKETWILHHHIASVE
10 20 30 40 50
60 70 80 90 100 110
pF1KE5 KQATTATGCPLLIRCKNFQIIQLIIPQERDCHDVYISLIRLARPVKYEELYCFSFNPMLD
: : :..::::.:.::::. ...:.:.::::::.: ::..:.. .:::.:: ::.:: .
XP_011 KLALTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 KEEREQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGS
:: ::: ::::.::: :::.:: .:::::.::::..:..:: :::::. :. :::::
XP_011 DSERLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 SKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFSARCLEDEQMLQAIRKANPGSDFVYVV
:::::. ::::::::..:..:.::: :::::::::::::::..:::: :::: . ..::.
XP_011 SKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVM
180 190 200 210 220 230
240 250 260
pF1KE5 DTRPK--------------------------------------LNAMANRAAGKGYENED
::::: :::::::::::::::::
XP_011 DTRPKRRMQSWWATQKDIGRIIVRISSKIQNDEKIRESNEKKRLNAMANRAAGKGYENED
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE5 NYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLRHIKAIMDAGI
:::::.:::.:::::::::.::::.::: :. :..:: :::.:::::::::.:::.:
XP_011 NYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAI
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE5 FIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKF
:.:::.. :.::::::::::::::.::::..::::: .:::.::::::::::::::::::
XP_011 FLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKF
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE5 NHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLC
..: :.:::::::.:::. ::.::::.: :::: ::::.: ::..:..::.::::::::
XP_011 SERCGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLG
420 430 440 450 460 470
450 460 470 480 490 500
pF1KE5 NSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYKFWS
: ::::.:::..:.::::: : ... :::::. .. . :. :.: .: .:::
XP_011 NCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRF--TVLEPNT-VSFNFKFWR
480 490 500 510 520 530
510 520 530 540 550 560
pF1KE5 GMYNRFEKGMQPRQSVTDYLMAVKEETQQLEEELEALEERLEKIQKVQLNCTKVKSKQSE
.::..:.. ..::::: . .: ..:...:::.... :: .... .. : . . .:.
XP_011 NMYHQFDRTLHPRQSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTD--GILTKELL
540 550 560 570 580 590
570 580 590 600 610
pF1KE5 PSKHS---GFSTSDNSIANTPQDYSGNMKSFPSRSPSQGDEDSALILTQDNLKSSDPDLS
: : ...:: .: . .... . ::. :. .....:.:
XP_011 HSVHPESPNLKTSLCFKEQTLLPVNDALRTIEGSSPA----DNRYSEYAEEFSKSEP---
600 610 620 630 640
620 630 640 650 660
pF1KE5 ANSDQESGVEDLSCRSPSGGEHAPSEDSGKDRDSDEAVFLTA
: . : :: ..:
XP_011 AVVSLEYGVARMTC
650
>>XP_005274432 (OMIM: 601382,603557) PREDICTED: myotubul (571 aa)
initn: 846 init1: 529 opt: 1251 Z-score: 1127.2 bits: 218.7 E(85289): 4.8e-56
Smith-Waterman score: 1251; 38.9% identity (67.6% similar) in 540 aa overlap (15-536:19-543)
10 20 30 40 50
pF1KE5 MEHIRTPKVENVRLVDRVSPKKAAL-GTLYLTATHVIFVENSPDARKETWILHSQ-
: . : .:. ::: .: .. : . : ..: ..
XP_005 MEEPPLLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYF---KSMERDPPFVLDASL
10 20 30 40 50
60 70 80 90 100
pF1KE5 --ISTIEKQATTAT----GCPLLIRCKNFQIIQLI-IPQERDCHDVYISLIRLARPVKYE
:. .:: . ... . : ::... ... :. : .... .:.. : ::. .
XP_005 GVINRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNN
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE5 -ELYCFSFNPMLDKEEREQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELY
:. : .. .. :.:: : : :: :.:.::. :... .:. :..::.::. :
XP_005 LPLFAFEYKEVFP----ENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE5 VPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFSA-RCLEDEQMLQA
:: . . . ..:::: :.::::. . ...:.: : :::. : :. : :::..:::
XP_005 VPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQA
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE5 IRKANPGSDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQK
: .: : ... :.::..::.::.: : :::.:: :.: .. :. :.::::::.::.:
XP_005 IMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRK
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE5 MLEVCELKSPSMSDFLW--GLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWD
. :. :.. . : .::.. ::.::: :. ... :: : .::.::::::::
XP_005 LKEIVY---PNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWD
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE5 RTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEI--SPVIDQ
::::. :.: :.:: .:::..:: ::.::.:.::::.:. : :. : . . :::. :
XP_005 RTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQ
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE5 FIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWA
::.::::. .::: :::::: ::: : :.::: ::.:::::...: . .. .:: :::.
XP_005 FIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWS
420 430 440 450 460 470
470 480 490 500 510 520
pF1KE5 HLWKNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPRQSVTDY-
.. .. :. :::. : .. .:. :.. . ..: :.: :.. :.:.. . .
XP_005 YINSQLEDFTNPLY---GSYSNHVLY-PVASMRHL-ELWVGYYIRWNPRMKPQEPIHNRY
480 490 500 510 520
530 540 550 560 570
pF1KE5 --LMAVKEETQQLEEELEALEERLEKIQKVQLNCTKVKSKQSEPSKHSGFSTSDNSIANT
:.: . : :. :::.
XP_005 KELLAKRAELQKKVEELQREISNRSTSSSERASSPAQCVTPVQTVV
530 540 550 560 570
660 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 06:12:22 2016 done: Tue Nov 8 06:12:23 2016
Total Scan time: 6.840 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]