Result of FASTA (omim) for
pFN21AE4153
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4153, 588 aa
1>>>pF1KE4153 588 - 588 aa - 588 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.5923+/-0.000555; mu= 6.1863+/- 0.034
mean_var=186.0065+/-40.132, 0's: 0 Z-trim(111.2): 697 B-trim: 141 in 1/55
Lambda= 0.094039
statistics sampled from 18909 (19735) to 18909 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.59), E-opt: 0.2 (0.231), width: 16
Scan time: 10.140
The best scores are: opt bits E(85289)
XP_016876858 (OMIM: 605759) PREDICTED: ankyrin rep ( 600) 1142 168.9 4.4e-41
XP_011535137 (OMIM: 605759) PREDICTED: ankyrin rep ( 533) 1112 164.8 6.7e-40
NP_057234 (OMIM: 605759) ankyrin repeat and SOCS b ( 587) 1112 164.8 7.2e-40
XP_005267815 (OMIM: 605759) PREDICTED: ankyrin rep ( 635) 1112 164.8 7.6e-40
NP_001189358 (OMIM: 605759) ankyrin repeat and SOC ( 635) 1112 164.8 7.6e-40
XP_011535136 (OMIM: 605759) PREDICTED: ankyrin rep ( 583) 945 142.1 4.8e-33
NP_057199 (OMIM: 605760) ankyrin repeat and SOCS b ( 518) 586 93.4 2e-18
NP_665862 (OMIM: 605760) ankyrin repeat and SOCS b ( 445) 483 79.3 2.9e-14
NP_001188894 (OMIM: 605760) ankyrin repeat and SOC ( 445) 483 79.3 2.9e-14
XP_016863596 (OMIM: 106410,600919) PREDICTED: anky (1797) 465 77.5 4.3e-13
XP_016863595 (OMIM: 106410,600919) PREDICTED: anky (1806) 465 77.5 4.3e-13
XP_016863591 (OMIM: 106410,600919) PREDICTED: anky (1838) 465 77.5 4.3e-13
XP_016863589 (OMIM: 106410,600919) PREDICTED: anky (1846) 465 77.5 4.3e-13
XP_016863586 (OMIM: 106410,600919) PREDICTED: anky (1858) 465 77.5 4.4e-13
XP_016863580 (OMIM: 106410,600919) PREDICTED: anky (1879) 465 77.5 4.4e-13
XP_016871638 (OMIM: 600465,615493) PREDICTED: anky (1720) 441 74.2 3.9e-12
XP_016871637 (OMIM: 600465,615493) PREDICTED: anky (1725) 441 74.2 4e-12
XP_016871636 (OMIM: 600465,615493) PREDICTED: anky (1735) 441 74.2 4e-12
XP_016871635 (OMIM: 600465,615493) PREDICTED: anky (1737) 441 74.2 4e-12
XP_016871634 (OMIM: 600465,615493) PREDICTED: anky (1738) 441 74.2 4e-12
XP_016871633 (OMIM: 600465,615493) PREDICTED: anky (1741) 441 74.2 4e-12
XP_016871632 (OMIM: 600465,615493) PREDICTED: anky (1742) 441 74.2 4e-12
XP_016871631 (OMIM: 600465,615493) PREDICTED: anky (1747) 441 74.2 4e-12
XP_016871630 (OMIM: 600465,615493) PREDICTED: anky (1751) 441 74.2 4e-12
XP_016871629 (OMIM: 600465,615493) PREDICTED: anky (1763) 441 74.2 4e-12
XP_016871628 (OMIM: 600465,615493) PREDICTED: anky (1764) 441 74.2 4e-12
XP_016871627 (OMIM: 600465,615493) PREDICTED: anky (1785) 441 74.2 4.1e-12
XP_016871626 (OMIM: 600465,615493) PREDICTED: anky (1786) 441 74.2 4.1e-12
XP_016871625 (OMIM: 600465,615493) PREDICTED: anky (1795) 441 74.2 4.1e-12
XP_016871624 (OMIM: 600465,615493) PREDICTED: anky (1838) 441 74.2 4.1e-12
XP_016871623 (OMIM: 600465,615493) PREDICTED: anky (1845) 441 74.2 4.2e-12
XP_016871622 (OMIM: 600465,615493) PREDICTED: anky (1850) 441 74.2 4.2e-12
XP_016871621 (OMIM: 600465,615493) PREDICTED: anky (1855) 441 74.2 4.2e-12
NP_001191332 (OMIM: 600465,615493) ankyrin-3 isofo (1861) 441 74.2 4.2e-12
XP_016871620 (OMIM: 600465,615493) PREDICTED: anky (1862) 441 74.2 4.2e-12
XP_016871619 (OMIM: 600465,615493) PREDICTED: anky (1866) 441 74.2 4.2e-12
NP_001307803 (OMIM: 600465,615493) ankyrin-3 isofo (1867) 441 74.2 4.2e-12
NP_001191333 (OMIM: 600465,615493) ankyrin-3 isofo (1868) 441 74.2 4.2e-12
XP_005269772 (OMIM: 600465,615493) PREDICTED: anky (1885) 441 74.2 4.2e-12
XP_016871618 (OMIM: 600465,615493) PREDICTED: anky (1888) 441 74.2 4.2e-12
XP_016871617 (OMIM: 600465,615493) PREDICTED: anky (1889) 441 74.2 4.2e-12
XP_006717865 (OMIM: 600465,615493) PREDICTED: anky (1898) 441 74.3 4.2e-12
XP_016871616 (OMIM: 600465,615493) PREDICTED: anky (2603) 441 74.4 5.3e-12
XP_016871615 (OMIM: 600465,615493) PREDICTED: anky (2612) 441 74.4 5.3e-12
XP_016871614 (OMIM: 600465,615493) PREDICTED: anky (2646) 441 74.4 5.4e-12
XP_016871613 (OMIM: 600465,615493) PREDICTED: anky (2647) 441 74.4 5.4e-12
XP_016871612 (OMIM: 600465,615493) PREDICTED: anky (2655) 441 74.4 5.4e-12
XP_011538011 (OMIM: 600465,615493) PREDICTED: anky (2656) 441 74.4 5.4e-12
XP_016871611 (OMIM: 600465,615493) PREDICTED: anky (2728) 441 74.4 5.5e-12
XP_006717859 (OMIM: 600465,615493) PREDICTED: anky (2758) 441 74.4 5.5e-12
>>XP_016876858 (OMIM: 605759) PREDICTED: ankyrin repeat (600 aa)
initn: 1035 init1: 751 opt: 1142 Z-score: 858.6 bits: 168.9 E(85289): 4.4e-41
Smith-Waterman score: 1142; 33.8% identity (66.6% similar) in 580 aa overlap (9-576:27-597)
10 20 30
pF1KE4 MDTNDDPDEDHLTSYDIQLSIQE------SIEASKTALC---
::.:... :. :. . . ::. .: :
XP_016 MATQISTRGSQCTIGQEEYSLYSSLSEDELVQMAIEQSLADKTRGPTTAEATASA-CTNR
10 20 30 40 50
40 50 60 70 80 90
pF1KE4 -PERFVPLSAQNRKLVEAIKQGHILELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQIL
: .: : . :..:::.: :. ..: . : ...::.:::::. :
XP_016 QPAHFYPWTRPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCL
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE4 EIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAV
. ::. .: . .: . :: . ::. : .. . .::. :. :. .: . :::: :
XP_016 K-VLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKAC
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE4 KKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVT
.. . . :. :..::.. .. : . :.:.::..... ... .:.. :..:. ....:.:
XP_016 ERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGIT
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE4 PLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVP
:: :::. :. ..:. : . :.:. . :.:.::.:.:: . . . . .:: :...:
XP_016 PLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKT
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE4 NRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGF
:. : ::.: :. .:.: ...:.::::.. ::.::..:.: ::. .. . :: :. :
XP_016 NKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARF
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE4 DVNTLLADHISQSYDDERKTALYFAVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANN
:::: :: . .. :.:.:..:::::: ::.:. ::.:: ::::: : .. ::::.: .
XP_016 DVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGC
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE4 YEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVEMCFDCMHGD
. ..:::.::::.. : . .. : ::..:..:.. .:..:.. : . : ::.:..:.
XP_016 LRTMQLLLDHGANIDAY-IATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGN
420 430 440 450 460 470
460 470 480 490 500 510
pF1KE4 IFGNSFVW--SEIQEEVLPGWTSCVIKDNPFCEFITVPWMKHLVGRVTRVLIDYMDYVPL
:.... :.. ::::...: ... .: . ::.::. : :
XP_016 GPHPPAPQPSSRFNDAPAADKEPSVVQ---FCEFVSAPEVSRWAGPIIDVLLDYVGNVQL
480 490 500 510 520 530
520 530 540 550 560 570
pF1KE4 CAKLKSALEVQREWPEIRQILENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQ
:..:: .. ..: :.. : : : :::::..:. .: .. .. :::: .
XP_016 CSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRI---KLLDTLPLPGRLI
540 550 560 570 580 590
580
pF1KE4 RYILFKEYDLYGQELKLT
::. ..
XP_016 RYLKYENTQ
600
>>XP_011535137 (OMIM: 605759) PREDICTED: ankyrin repeat (533 aa)
initn: 1035 init1: 751 opt: 1112 Z-score: 837.3 bits: 164.8 E(85289): 6.7e-40
Smith-Waterman score: 1112; 34.6% identity (68.0% similar) in 532 aa overlap (47-576:7-530)
20 30 40 50 60 70
pF1KE4 IQLSIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHILELQEYVKYKYAMDEADEKG
:..:::.: :. ..: . : ...:
XP_011 MRPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEG
10 20 30
80 90 100 110 120 130
pF1KE4 WFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVW
:.:::::. :. ::. .: . .: . :: . ::. : .. . .::. :.
XP_011 WLPLHEAAYYGQVGCLK-VLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAE
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE4 PNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALL
:. .: . :::: : .. . . :. :..::.. .. : . :.:.::..... ... .:
XP_011 PDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQIL
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE4 LKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNP
.. :..:. ....:.::: :::. :. ..:. : . :.:. . :.:.::.:.:: . .
XP_011 VSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHE
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE4 DCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGLTPIHSAA
. . .:: :...: :. : ::.: :. .:.: ...:.::::.. ::.::..:.: ::
XP_011 EVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAA
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE4 DGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFAVSNNDVHCTEVLLAAGADP
. .. . :: :. ::::: :: . .. :.:.:..:::::: ::.:. ::.:: ::::
XP_011 ERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADP
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE4 NLDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLL
: : .. ::::.: . . ..:::.::::.. : . .. : ::..:..:.. .:..:.
XP_011 NRDVISPLLVAIRHGCLRTMQLLLDHGANIDAY-IATHPTAFPATIMFAMKCLSLLKFLM
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE4 NNGYQVEMCFDCMHGDIFGNSFVW--SEIQEEVLPGWTSCVIKDNPFCEFITVPWMKHLV
. : . : ::.:..:. :.... :.. ::::...: ... .
XP_011 DLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQ---FCEFVSAPEVSRWA
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE4 GRVTRVLIDYMDYVPLCAKLKSALEVQREWPEIRQILENPCSLKHLCRLKIRRLMGLQKL
: . ::.::. : ::..:: .. ..: :.. : : : :::::..:. .: ..
XP_011 GPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRI
460 470 480 490 500 510
560 570 580
pF1KE4 CQPASVEKLPLPPAIQRYILFKEYDLYGQELKLT
.. :::: . ::. ..
XP_011 ---KLLDTLPLPGRLIRYLKYENTQ
520 530
>>NP_057234 (OMIM: 605759) ankyrin repeat and SOCS box p (587 aa)
initn: 1035 init1: 751 opt: 1112 Z-score: 836.7 bits: 164.8 E(85289): 7.2e-40
Smith-Waterman score: 1112; 34.6% identity (68.0% similar) in 532 aa overlap (47-576:61-584)
20 30 40 50 60 70
pF1KE4 IQLSIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHILELQEYVKYKYAMDEADEKG
:..:::.: :. ..: . : ...:
NP_057 ARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEG
40 50 60 70 80 90
80 90 100 110 120 130
pF1KE4 WFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVW
:.:::::. :. ::. .: . .: . :: . ::. : .. . .::. :.
NP_057 WLPLHEAAYYGQVGCLK-VLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAE
100 110 120 130 140
140 150 160 170 180 190
pF1KE4 PNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALL
:. .: . :::: : .. . . :. :..::.. .. : . :.:.::..... ... .:
NP_057 PDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQIL
150 160 170 180 190 200
200 210 220 230 240 250
pF1KE4 LKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNP
.. :..:. ....:.::: :::. :. ..:. : . :.:. . :.:.::.:.:: . .
NP_057 VSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHE
210 220 230 240 250 260
260 270 280 290 300 310
pF1KE4 DCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGLTPIHSAA
. . .:: :...: :. : ::.: :. .:.: ...:.::::.. ::.::..:.: ::
NP_057 EVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAA
270 280 290 300 310 320
320 330 340 350 360 370
pF1KE4 DGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFAVSNNDVHCTEVLLAAGADP
. .. . :: :. ::::: :: . .. :.:.:..:::::: ::.:. ::.:: ::::
NP_057 ERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADP
330 340 350 360 370 380
380 390 400 410 420 430
pF1KE4 NLDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLL
: : .. ::::.: . . ..:::.::::.. : . .. : ::..:..:.. .:..:.
NP_057 NRDVISPLLVAIRHGCLRTMQLLLDHGANIDAY-IATHPTAFPATIMFAMKCLSLLKFLM
390 400 410 420 430 440
440 450 460 470 480 490
pF1KE4 NNGYQVEMCFDCMHGDIFGNSFVW--SEIQEEVLPGWTSCVIKDNPFCEFITVPWMKHLV
. : . : ::.:..:. :.... :.. ::::...: ... .
NP_057 DLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQ---FCEFVSAPEVSRWA
450 460 470 480 490 500
500 510 520 530 540 550
pF1KE4 GRVTRVLIDYMDYVPLCAKLKSALEVQREWPEIRQILENPCSLKHLCRLKIRRLMGLQKL
: . ::.::. : ::..:: .. ..: :.. : : : :::::..:. .: ..
NP_057 GPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRI
510 520 530 540 550 560
560 570 580
pF1KE4 CQPASVEKLPLPPAIQRYILFKEYDLYGQELKLT
.. :::: . ::. ..
NP_057 ---KLLDTLPLPGRLIRYLKYENTQ
570 580
>>XP_005267815 (OMIM: 605759) PREDICTED: ankyrin repeat (635 aa)
initn: 1035 init1: 751 opt: 1112 Z-score: 836.3 bits: 164.8 E(85289): 7.6e-40
Smith-Waterman score: 1112; 34.6% identity (68.0% similar) in 532 aa overlap (47-576:109-632)
20 30 40 50 60 70
pF1KE4 IQLSIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHILELQEYVKYKYAMDEADEKG
:..:::.: :. ..: . : ...:
XP_005 ARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEG
80 90 100 110 120 130
80 90 100 110 120 130
pF1KE4 WFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVW
:.:::::. :. ::. .: . .: . :: . ::. : .. . .::. :.
XP_005 WLPLHEAAYYGQVGCLK-VLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAE
140 150 160 170 180 190
140 150 160 170 180 190
pF1KE4 PNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALL
:. .: . :::: : .. . . :. :..::.. .. : . :.:.::..... ... .:
XP_005 PDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQIL
200 210 220 230 240 250
200 210 220 230 240 250
pF1KE4 LKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNP
.. :..:. ....:.::: :::. :. ..:. : . :.:. . :.:.::.:.:: . .
XP_005 VSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHE
260 270 280 290 300 310
260 270 280 290 300 310
pF1KE4 DCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGLTPIHSAA
. . .:: :...: :. : ::.: :. .:.: ...:.::::.. ::.::..:.: ::
XP_005 EVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAA
320 330 340 350 360 370
320 330 340 350 360 370
pF1KE4 DGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFAVSNNDVHCTEVLLAAGADP
. .. . :: :. ::::: :: . .. :.:.:..:::::: ::.:. ::.:: ::::
XP_005 ERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADP
380 390 400 410 420 430
380 390 400 410 420 430
pF1KE4 NLDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLL
: : .. ::::.: . . ..:::.::::.. : . .. : ::..:..:.. .:..:.
XP_005 NRDVISPLLVAIRHGCLRTMQLLLDHGANIDAY-IATHPTAFPATIMFAMKCLSLLKFLM
440 450 460 470 480 490
440 450 460 470 480 490
pF1KE4 NNGYQVEMCFDCMHGDIFGNSFVW--SEIQEEVLPGWTSCVIKDNPFCEFITVPWMKHLV
. : . : ::.:..:. :.... :.. ::::...: ... .
XP_005 DLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQ---FCEFVSAPEVSRWA
500 510 520 530 540 550
500 510 520 530 540 550
pF1KE4 GRVTRVLIDYMDYVPLCAKLKSALEVQREWPEIRQILENPCSLKHLCRLKIRRLMGLQKL
: . ::.::. : ::..:: .. ..: :.. : : : :::::..:. .: ..
XP_005 GPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRI
560 570 580 590 600 610
560 570 580
pF1KE4 CQPASVEKLPLPPAIQRYILFKEYDLYGQELKLT
.. :::: . ::. ..
XP_005 ---KLLDTLPLPGRLIRYLKYENTQ
620 630
>>NP_001189358 (OMIM: 605759) ankyrin repeat and SOCS bo (635 aa)
initn: 1035 init1: 751 opt: 1112 Z-score: 836.3 bits: 164.8 E(85289): 7.6e-40
Smith-Waterman score: 1112; 34.6% identity (68.0% similar) in 532 aa overlap (47-576:109-632)
20 30 40 50 60 70
pF1KE4 IQLSIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHILELQEYVKYKYAMDEADEKG
:..:::.: :. ..: . : ...:
NP_001 ARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEG
80 90 100 110 120 130
80 90 100 110 120 130
pF1KE4 WFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVW
:.:::::. :. ::. .: . .: . :: . ::. : .. . .::. :.
NP_001 WLPLHEAAYYGQVGCLK-VLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAE
140 150 160 170 180 190
140 150 160 170 180 190
pF1KE4 PNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALL
:. .: . :::: : .. . . :. :..::.. .. : . :.:.::..... ... .:
NP_001 PDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQIL
200 210 220 230 240 250
200 210 220 230 240 250
pF1KE4 LKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNP
.. :..:. ....:.::: :::. :. ..:. : . :.:. . :.:.::.:.:: . .
NP_001 VSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHE
260 270 280 290 300 310
260 270 280 290 300 310
pF1KE4 DCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGLTPIHSAA
. . .:: :...: :. : ::.: :. .:.: ...:.::::.. ::.::..:.: ::
NP_001 EVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAA
320 330 340 350 360 370
320 330 340 350 360 370
pF1KE4 DGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFAVSNNDVHCTEVLLAAGADP
. .. . :: :. ::::: :: . .. :.:.:..:::::: ::.:. ::.:: ::::
NP_001 ERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADP
380 390 400 410 420 430
380 390 400 410 420 430
pF1KE4 NLDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLL
: : .. ::::.: . . ..:::.::::.. : . .. : ::..:..:.. .:..:.
NP_001 NRDVISPLLVAIRHGCLRTMQLLLDHGANIDAY-IATHPTAFPATIMFAMKCLSLLKFLM
440 450 460 470 480 490
440 450 460 470 480 490
pF1KE4 NNGYQVEMCFDCMHGDIFGNSFVW--SEIQEEVLPGWTSCVIKDNPFCEFITVPWMKHLV
. : . : ::.:..:. :.... :.. ::::...: ... .
NP_001 DLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQ---FCEFVSAPEVSRWA
500 510 520 530 540 550
500 510 520 530 540 550
pF1KE4 GRVTRVLIDYMDYVPLCAKLKSALEVQREWPEIRQILENPCSLKHLCRLKIRRLMGLQKL
: . ::.::. : ::..:: .. ..: :.. : : : :::::..:. .: ..
NP_001 GPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRI
560 570 580 590 600 610
560 570 580
pF1KE4 CQPASVEKLPLPPAIQRYILFKEYDLYGQELKLT
.. :::: . ::. ..
NP_001 ---KLLDTLPLPGRLIRYLKYENTQ
620 630
>>XP_011535136 (OMIM: 605759) PREDICTED: ankyrin repeat (583 aa)
initn: 952 init1: 668 opt: 945 Z-score: 714.3 bits: 142.1 E(85289): 4.8e-33
Smith-Waterman score: 969; 32.8% identity (65.8% similar) in 503 aa overlap (91-576:85-580)
70 80 90 100 110 120
pF1KE4 EYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVK
... :.. ..:.. . :: :.:
XP_011 ACTNRQPAHFYPWTRSTAPPESSPARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIK
60 70 80 90 100 110
130 140 150 160
pF1KE4 AGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSY---------------DMVSTLIK
: : ..:....: : .: :: :. :. . :. :..
XP_011 DGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRACERKNAEAVKILVQ
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 HNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV
::.. .. : . :.:.::..... ... .:.. :..:. ....:.::: :::. :. ..
XP_011 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 LEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAY
:. : . :.:. . :.:.::.:.:: . . . . .:: :...: :. : ::.: :.
XP_011 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASK
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 EGHYLALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQS
.:.: ...:.::::.. ::.::..:.: ::. .. . :: :. ::::: :: . ..
XP_011 KGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 YDDERKTALYFAVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGAN
:.:.:..:::::: ::.:. ::.:: ::::: : .. ::::.: . . ..:::.::::
XP_011 YEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGAN
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 VNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVEMCFDCMHGDIFGNSFVW--SEI
.. : . .. : ::..:..:.. .:..:.. : . : ::.:..:. :..
XP_011 IDAY-IATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRF
420 430 440 450 460 470
470 480 490 500 510 520
pF1KE4 QEEVLPGWTSCVIKDNPFCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSALEVQRE
.. :.. ::::...: ... .: . ::.::. : ::..:: .. ..
XP_011 NDAPAADKEPSVVQ---FCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFED
480 490 500 510 520 530
530 540 550 560 570 580
pF1KE4 WPEIRQILENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQ
: :.. : : : :::::..:. .: .. .. :::: . ::. ..
XP_011 WAVIKEKAEPPRPLAHLCRLRVRKAIGKYRI---KLLDTLPLPGRLIRYLKYENTQ
540 550 560 570 580
pF1KE4 ELKLT
>>NP_057199 (OMIM: 605760) ankyrin repeat and SOCS box p (518 aa)
initn: 485 init1: 199 opt: 586 Z-score: 451.8 bits: 93.4 E(85289): 2e-18
Smith-Waterman score: 645; 29.7% identity (58.1% similar) in 539 aa overlap (50-577:17-502)
20 30 40 50 60 70
pF1KE4 SIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHILELQEYVKYKYAMDEADEKGWFP
: ..:.. :.. .: ..: ::..::.:
NP_057 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMP
10 20 30 40
80 90 100 110 120 130
pF1KE4 LHEAVVQPIQQILEIVLDA-SYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPN
.:::. . . :.....: : .. ..:: .: : ::.. : . :. ::: :. ::
NP_057 IHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPN
50 60 70 80 90 100
140 150 160 170 180 190
pF1KE4 TKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLD-QPCVKRWSAMHEAAKQGRKDIVALLL
. . . :::..::..:. :.. :..:..... . . :...:.:. : .:. :::
NP_057 ATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLL
110 120 130 140 150 160
200 210 220 230 240 250
pF1KE4 KHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPD
..:.: . .: ::.::: :::.::. . : :: .:..: : : :. :: :: :.
NP_057 RKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTK
170 180 190 200 210 220
260 270 280 290 300 310
pF1KE4 CISLLLEYGGSGNV--PNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGL---TPI
:. ::: :.. .. . . .:::: :: :: : :::.:.. .:: .:.
NP_057 CVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC--DTGLNKVSPV
230 240 250 260 270 280
320 330 340 350 360
pF1KE4 HSAADGQNAQCLELLIENGF--DVNTLLADHISQSYDDE-RKTALYFAVSNNDVHCTEVL
.::. : . .:::.:..::. :... :. .:. .: .:.. : .:
NP_057 YSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVN-------IL
290 300 310 320 330
370 380 390 400 410 420
pF1KE4 LAAGADPN-LDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALND
: ::. : : :: . ... : : .: .: ... . :. . .. :
NP_057 LKYGAQINELHLAYCL----KYEKFSIFRYFLRKGCSLGPW-NHIYEFVNHAIKAQAKYK
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE4 EVMLRLLLNNGYQVEMCFDCMHGDIFGNSFVWSEIQEEVLPGWTSCVIKDNPFCEFITVP
: . .::. :.. . . : :: : . : :. . . .
NP_057 EWLPHLLVA-GFD-PLILLC-------NS-------------WIDSVSIDTLIFTLEFTN
400 410 420 430
490 500 510 520 530 540
pF1KE4 WMKHLVGRVTRVLIDYMDYVPLCAKLKSALEVQREWPEIRQILENPCSLKHLCRLKIRRL
: : :. : :.: :. ..: : ..: : :: :::::.::
NP_057 W-KTLAPAVERML---------SARASNA------WILQQHIATVP-SLTHLCRLEIRSS
440 450 460 470
550 560 570 580
pF1KE4 MGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQELKLT
. ..: . . . .:::: ... :.:...
NP_057 LKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
480 490 500 510
>>NP_665862 (OMIM: 605760) ankyrin repeat and SOCS box p (445 aa)
initn: 484 init1: 199 opt: 483 Z-score: 377.1 bits: 79.3 E(85289): 2.9e-14
Smith-Waterman score: 542; 29.9% identity (56.5% similar) in 481 aa overlap (107-577:2-429)
80 90 100 110 120 130
pF1KE4 WFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVW
:: .: : ::.. : . :. ::: :.
NP_665 MKTFEGFCALHLAASQGHWKIVQILLEAGAD
10 20 30
140 150 160 170 180 190
pF1KE4 PNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLD-QPCVKRWSAMHEAAKQGRKDIVAL
::. . . :::..::..:. :.. :..:..... . . :...:.:. : .:. :
NP_665 PNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKL
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE4 LLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGN
::..:.: . .: ::.::: :::.::. . : :: .:..: : : :. :: :: :.
NP_665 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE4 PDCISLLLEYGGSGNV--PNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGL---T
:. ::: :.. .. . . .:::: :: :: : :::.:.. .:: .
NP_665 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC--DTGLNKVS
160 170 180 190 200
320 330 340 350 360
pF1KE4 PIHSAADGQNAQCLELLIENGF--DVNTLLADHISQSYDDE-RKTALYFAVSNNDVHCTE
:..::. : . .:::.:..::. :... :. .:. .: .:.. :
NP_665 PVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVN-------
210 220 230 240 250 260
370 380 390 400 410 420
pF1KE4 VLLAAGADPN-LDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYAL
.:: ::. : : :: . ... : : .: .: ... . :. . .. :
NP_665 ILLKYGAQINELHLAYCL----KYEKFSIFRYFLRKGCSLGPW-NHIYEFVNHAIKAQAK
270 280 290 300 310
430 440 450 460 470 480
pF1KE4 NDEVMLRLLLNNGYQVEMCFDCMHGDIFGNSFVWSEIQEEVLPGWTSCVIKDNPFCEFIT
: . .::. :.. . . : :: : . : :. . .
NP_665 YKEWLPHLLVA-GFD-PLILLC-------NS-------------WIDSVSIDTLIFTLEF
320 330 340 350
490 500 510 520 530 540
pF1KE4 VPWMKHLVGRVTRVLIDYMDYVPLCAKLKSALEVQREWPEIRQILENPCSLKHLCRLKIR
. : : :. : :.: :. ..: : ..: : :: :::::.::
NP_665 TNW-KTLAPAVERML---------SARASNA------WILQQHIATVP-SLTHLCRLEIR
360 370 380 390
550 560 570 580
pF1KE4 RLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQELKLT
. ..: . . . .:::: ... :.:...
NP_665 SSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
400 410 420 430 440
>>NP_001188894 (OMIM: 605760) ankyrin repeat and SOCS bo (445 aa)
initn: 484 init1: 199 opt: 483 Z-score: 377.1 bits: 79.3 E(85289): 2.9e-14
Smith-Waterman score: 542; 29.9% identity (56.5% similar) in 481 aa overlap (107-577:2-429)
80 90 100 110 120 130
pF1KE4 WFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVW
:: .: : ::.. : . :. ::: :.
NP_001 MKTFEGFCALHLAASQGHWKIVQILLEAGAD
10 20 30
140 150 160 170 180 190
pF1KE4 PNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLD-QPCVKRWSAMHEAAKQGRKDIVAL
::. . . :::..::..:. :.. :..:..... . . :...:.:. : .:. :
NP_001 PNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKL
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE4 LLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGN
::..:.: . .: ::.::: :::.::. . : :: .:..: : : :. :: :: :.
NP_001 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE4 PDCISLLLEYGGSGNV--PNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGL---T
:. ::: :.. .. . . .:::: :: :: : :::.:.. .:: .
NP_001 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC--DTGLNKVS
160 170 180 190 200
320 330 340 350 360
pF1KE4 PIHSAADGQNAQCLELLIENGF--DVNTLLADHISQSYDDE-RKTALYFAVSNNDVHCTE
:..::. : . .:::.:..::. :... :. .:. .: .:.. :
NP_001 PVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVN-------
210 220 230 240 250 260
370 380 390 400 410 420
pF1KE4 VLLAAGADPN-LDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYAL
.:: ::. : : :: . ... : : .: .: ... . :. . .. :
NP_001 ILLKYGAQINELHLAYCL----KYEKFSIFRYFLRKGCSLGPW-NHIYEFVNHAIKAQAK
270 280 290 300 310
430 440 450 460 470 480
pF1KE4 NDEVMLRLLLNNGYQVEMCFDCMHGDIFGNSFVWSEIQEEVLPGWTSCVIKDNPFCEFIT
: . .::. :.. . . : :: : . : :. . .
NP_001 YKEWLPHLLVA-GFD-PLILLC-------NS-------------WIDSVSIDTLIFTLEF
320 330 340 350
490 500 510 520 530 540
pF1KE4 VPWMKHLVGRVTRVLIDYMDYVPLCAKLKSALEVQREWPEIRQILENPCSLKHLCRLKIR
. : : :. : :.: :. ..: : ..: : :: :::::.::
NP_001 TNW-KTLAPAVERML---------SARASNA------WILQQHIATVP-SLTHLCRLEIR
360 370 380 390
550 560 570 580
pF1KE4 RLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQELKLT
. ..: . . . .:::: ... :.:...
NP_001 SSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
400 410 420 430 440
>>XP_016863596 (OMIM: 106410,600919) PREDICTED: ankyrin- (1797 aa)
initn: 455 init1: 338 opt: 465 Z-score: 356.1 bits: 77.5 E(85289): 4.3e-13
Smith-Waterman score: 465; 29.6% identity (59.9% similar) in 362 aa overlap (50-407:384-734)
20 30 40 50 60 70
pF1KE4 SIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHILELQEYVKYKYAMDEADEKGWFP
: :...: .. ::: ... :.: :
XP_016 CGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTP
360 370 380 390 400 410
80 90 100 110 120 130
pF1KE4 LHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNT
.: :. . .:. ..:. . . . . ::: : .:..:: :: :: ::..:. ..
XP_016 IHVAAFMGHLNIVLLLLQNGASP--DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA
420 430 440 450 460 470
140 150 160 170 180 190
pF1KE4 KNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKH
. . .::: :: . :. ..:. :..: . : .. .. .: .:..:. :....::.
XP_016 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA
480 490 500 510 520 530
200 210 220 230 240 250
pF1KE4 GGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCI
:. : : ::: :::.:: :: . :... . . . . .: . : :: .. .
XP_016 GAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGYTPLHIAAKKNQMQIA
540 550 560 570 580 590
260 270 280 290 300 310
pF1KE4 SLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIR-KSGLTPIHSAADG
: ::.::. :. .. : :.: :. ::: . :. .. . ::::: .: ::.
XP_016 STLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE
600 610 620 630 640 650
320 330 340 350 360 370
pF1KE4 QNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFAVSNNDVHCTEVLLAAGADPNL
.... ..: ..: : .. : . .: : : : ..:. .. :: ::. :
XP_016 DKVNVADILTKHGADQDA----HTKLGY-----TPLIVACHYGNVKMVNFLLKQGANVNA
660 670 680 690 700
380 390 400 410 420 430
pF1KE4 DPLNC---LLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLL
: : :.. .. .:. .::.:::. :
XP_016 KTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVV
710 720 730 740 750 760
440 450 460 470 480 490
pF1KE4 LNNGYQVEMCFDCMHGDIFGNSFVWSEIQEEVLPGWTSCVIKDNPFCEFITVPWMKHLVG
XP_016 TEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLP
770 780 790 800 810 820
>--
initn: 455 init1: 265 opt: 325 Z-score: 253.5 bits: 58.5 E(85289): 2.2e-07
Smith-Waterman score: 474; 29.5% identity (59.9% similar) in 342 aa overlap (50-382:50-376)
20 30 40 50 60 70
pF1KE4 SIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHILELQEYVKYKYAMDEADEKGWFP
: :.::. .:: . ..: : .::
XP_016 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE4 LHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNT
:: : . ....... . . . .. .: ::: .:.. . .. :. :::.:. .:
XP_016 LHIASLAGQAEVVKVLVKEGANI--NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST
80 90 100 110 120 130
140 150 160 170 180 190
pF1KE4 KNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKH
.. : ::: .:...: . :. :....: . : : :.: ::.. .::::..
XP_016 ATEDGFTPLAVALQQGHNQAVAILLENDT---KGKV-RLPALHIAARKDDTKSAALLLQN
140 150 160 170 180 190
200 210 220 230 240 250
pF1KE4 GGNVHLRDGF--------GVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAA
:. ... . : ::: .::.::. .: :...:. : : .: . : :.
XP_016 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS
200 210 220 230 240 250
260 270 280 290 300 310
pF1KE4 GGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIR-KSGLT
:: . ..:::. ::. .. .: : :.: :: :: ... :. . : :.::.
XP_016 KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS
260 270 280 290 300 310
320 330 340 350 360 370
pF1KE4 PIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFAVSNNDVHCTEVLL
:.: ::.:....:.. :... :. . :.. :::. :. . . :..::
XP_016 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL---------TALHVAAHCGHYRVTKLLL
320 330 340 350 360
380 390 400 410 420 430
pF1KE4 AAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEV
:.:: ::
XP_016 DKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLN
370 380 390 400 410 420
588 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 03:22:41 2016 done: Sun Nov 6 03:22:43 2016
Total Scan time: 10.140 Total Display time: 0.140
Function used was FASTA [36.3.4 Apr, 2011]